Lester, Henry A

(orcid 0000-0002-5470-5255)

Combined from CaltechAUTHORS

• Nichols, Aaron L.; Blumenfeld, Zack et al. (2023) Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane Journal of Neuroscience; Vol. 43; No. 13; https://doi.org/10.1523/jneurosci.1519-22.2022

• Haloi, Nandan; Huang, Shan et al. (2023) Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids https://doi.org/10.1101/2023.01.16.524298

• Knox, Hailey J.; Rego Campello, Hugo et al. (2022) Characterization of Binding Site Interactions and Selectivity Principles in the α3β4 Nicotinic Acetylcholine Receptor Journal of the American Chemical Society; Vol. 144; No. 35; https://doi.org/10.1021/jacs.2c06495

• Harrison, Neil L.; Abbott, Geoffrey W. et al. (2022) How many SARS-CoV-2 “viroporins” are really ion channels? Communications Biology; Vol. 5; No. 1; https://doi.org/10.1038/s42003-022-03669-2

• Nichols, Aaron L.; Blumenfeld, Zack et al. (2022) Selective Serotonin Reuptake Inhibitors Within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane https://doi.org/10.1101/2022.08.09.502705

• Muthusamy, Anand K.; Kim, Charlene H. et al. (2022) Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-Methadone for Use in Cells, Organelles, and Biofluids Journal of the American Chemical Society; Vol. 144; No. 19; https://doi.org/10.1021/jacs.2c02323

• Nichols, Aaron L.; Blumenfeld, Zack et al. (2022) Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands eLife; Vol. 11; https://doi.org/10.7554/eLife.74648

• Mulcahy, Matthew J.; Huard, Stephanie M. et al. (2021) Protein profiling in the habenula after chronic (–)-menthol exposure in mice Journal of Neurochemistry; Vol. 158; No. 6; https://doi.org/10.1111/jnc.15495

• Grant, Stephen N.; Lester, Henry A. (2021) Regulation of epithelial sodium channel activity by SARS-CoV-1 and SARS-CoV-2 proteins Biophysical Journal; Vol. 120; No. 14; https://doi.org/10.1016/j.bpj.2021.06.005

• Unger, Elizabeth K.; Keller, Jacob P. et al. (2020) Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning Cell; Vol. 183; No. 7; https://doi.org/10.1016/j.cell.2020.11.040

• Grant, Stephen; Lester, Henry A. (2020) Proteins for increased surface expression of the α6β4 nicotinic acetylcholine receptor: Nothing but good news? Journal of Clinical Investigation; Vol. 130; No. 11; https://doi.org/10.1172/jci143197

• Cohen, Bruce N.; Nichols, Aaron L. et al. (2020) Successful Cessation Programs that Reduce Comorbidity May Explain Surprisingly Low Smoking Rates Among Hospitalized COVID-19 Patients https://doi.org/10.32388/WURFH0

• Borden, Philip M.; Shivange, Amol V. et al. (2020) A fast genetically encoded fluorescent sensor for faithful in vivo acetylcholine detection in mice, fish, worms and flies https://doi.org/10.1101/2020.02.07.939504

• Grant, Stephen; Muthusamy, Anand K. et al. (2020) Antagonists Pharmacologically Chaperone Opioid Receptors Biophysical Journal; Vol. 118; No. 3; In: 64th Annual Meeting of the Biophysical Society, 15-19 February 2020, San Diego, CA https://doi.org/10.1016/j.bpj.2019.11.328

• Mulcahy, Matthew J.; Huard, Stephanie M. et al. (2020) Brain Region-Specific nAChR and Associated Protein Abundance Alterations Following Chronic Nicotine and/or Menthol Exposure Journal of Proteome Research; Vol. 19; No. 1; https://doi.org/10.1021/acs.jproteome.9b00286

• Bera, Kallol; Kamajaya, Aron et al. (2019) Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum Frontiers in Cellular Neuroscience; Vol. 13; https://doi.org/10.3389/fncel.2019.00499

• Lester, Henry A.; Dougherty, Dennis A. (2019) Nicotine Bound to Its Receptors: New Structures for a Vexing Pathopharmacological Problem Neuron; Vol. 104; No. 3; https://doi.org/10.1016/j.neuron.2019.10.029

• Blom, Annet E. M.; Rego Campello, Hugo et al. (2019) Probing Binding Interactions of Cytisine Derivatives to the α4β2 Nicotinic Acetylcholine Receptor Journal of the American Chemical Society; Vol. 141; No. 40; https://doi.org/10.1021/jacs.9b06580

• Shivange, Amol V.; Borden, Philip M. et al. (2019) Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors Journal of General Physiology; Vol. 151; No. 6; https://doi.org/10.1085/jgp.201812201

• Bavan, Selvan; Kim, Charlene H. et al. (2019) Chronic menthol does not change stoichiometry or functional plasma membrane levels of mouse α3β4-containing nicotinic acetylcholine receptors Molecular Pharmacology; Vol. 95; No. 4; https://doi.org/10.1124/mol.118.114769

• Zhou, Chunyi; Gu, Weixin et al. (2019) Bidirectional dopamine modulation of excitatory and inhibitory synaptic inputs to subthalamic neuron subsets containing α4β2 or α7 nAChRs Neuropharmacology; Vol. 148; https://doi.org/10.1016/j.neuropharm.2019.01.015

• Henderson, Brandon J.; Grant, Stephen et al. (2018) Menthol stereoisomers exhibit different effects on α4β2 nAChR upregulation and dopamine neuron spontaneous firing eNeuro; Vol. 5; No. 6; https://doi.org/10.1523/eneuro.0465-18.2018

• Nichols, Aaron L.; Noridomi, Kaori et al. (2018) α1-FANGs: Protein Ligands Selective for the α-Bungarotoxin Site of the α1-Nicotinic Acetylcholine Receptor ACS Chemical Biology; Vol. 13; No. 9; https://doi.org/10.1021/acschembio.8b00513

• Subramaniam, Sudhakar R.; Magen, Iddo et al. (2018) Chronic nicotine improves cognitive and social impairment in mice overexpressing wild type α-synuclein Neurobiology of Disease; Vol. 117; https://doi.org/10.1016/j.nbd.2018.05.018

• Banala, Sambashiva; Arvin, Matthew C. et al. (2018) Photoactivatable drugs for nicotinic optopharmacology Nature Methods; Vol. 15; No. 5; https://resolver.caltech.edu/CaltechAUTHORS:20180402-095419703

• Bavan, Selvan; Patowary, Suparna et al. (2018) Effects of Chronic Menthol at Alpha3Beta4 (α3β4)-Containing Nicotinic Acetylcholine Receptors Biophysical Journal; Vol. 114; No. 3; In: 62nd Annual Meeting of the Biophysical-Society, February 17-21, 2018, San Francisco, CA https://doi.org/10.1016/j.bpj.2017.11.1691

• Muthusamy, Anand K.; Shivange, Amol V. et al. (2018) Microscopy Using Fluorescent Drug Biosensors for "Inside-Out Pharmacology" Biophysical Journal; Vol. 114; No. 3; In: 62nd Annual Meeting of the Biophysical-Society, February 17-21, 2018, San Francisco, CA https://doi.org/10.1016/j.bpj.2017.11.1990

• Parker, Rell L.; O'Neill, Heidi C. et al. (2017) Deletion of lynx1 reduces the function of α6* nicotinic receptors PLoS ONE; Vol. 12; No. 12; https://doi.org/10.1371/journal.pone.0188715

• Henderson, Brandon J.; Wall, Teagan R. et al. (2017) Menthol Enhances Nicotine Reward-Related Behavior by Potentiating Nicotine-Induced Changes in nAChR Function, nAChR Upregulation, and DA Neuron Excitability Neuropsychopharmacology; Vol. 42; No. 12; https://doi.org/10.1038/npp.2017.72

• Tarren, Josephine R.; Lester, Henry A. et al. (2017) Acute Ethanol Administration Upregulates Synaptic α4-Subunit of Neuronal Nicotinic Acetylcholine Receptors within the Nucleus Accumbens and Amygdala Frontiers in Molecular Neuroscience; Vol. 10; https://doi.org/10.3389/fnmol.2017.00338

• Shivange, Amol V.; Nichols, Aaron L. et al. (2017) Nicotine in the Endoplasmic Reticulum Journal of General Physiology; Vol. 149; No. 9; In: 71st Annual Meeting of the Society-of-General-Physiologists (SGP) on Optical Revolution in Physiology - From Membrane to Brain, 6-10 September 2017, Woods Hole, MA https://doi.org/10.1085/jgp.149.9.889

• Wall, Teagan R.; Henderson, Brandon J. et al. (2017) TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors Frontiers in Pharmacology; Vol. 8; https://doi.org/10.3389/fphar.2017.00641

• Mulcahy, Matthew J.; Lester, Henry A. (2017) Granulocytes as models for human protein marker identification following nicotine exposure Journal of Neurochemistry; Vol. 142; No. S2; In: XVth International Symposium on Cholinergic Mechanisms, 16-20 October 2016, Marseille Chanot, France https://doi.org/10.1111/jnc.14010

• Hurtado-Zavala, Joaquin I.; Ramachandran, Binu et al. (2017) TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus Nature Communications; Vol. 8; https://doi.org/10.1038/ncomms15878

• Kim, Jinho; Henley, Beverley M. et al. (2017) Incubator embedded cell culture imaging system (EmSight) based on Fourier ptychographic microscopy In: Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV; Series Proceedings of SPIE; No. 10068; In: Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV, 30 January-1 February 2017, San Francisco, CA https://doi.org/10.1117/12.2249906

• Post, Michael R.; Lester, Henry A. et al. (2017) Probing for and Quantifying Agonist Hydrogen Bonds in α6β2 Nicotinic Acetylcholine Receptors Biochemistry; Vol. 56; No. 13; https://doi.org/10.1021/acs.biochem.7b00213

• Mulcahy, Matthew J.; Wang, Jonathan H. et al. (2017) Region specific proteomic analysis of murine brain after chronic nicotine or menthol FASEB Journal; Vol. 31; No. S1; In: 2017 Annual Meeting of the American-Society-for-Pharmacology-and-Experimental-Therapeutics (ASPET) at Experimental Biology Meeting, 22-26 April 2017, Chicago, IL https://resolver.caltech.edu/CaltechAUTHORS:20170921-153023998

• Post, Michael R.; Tender, Gabrielle S. et al. (2017) Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors eNeuro; Vol. 4; No. 2; https://doi.org/10.1523/ENEURO.0032-17.2017

• Henley, Beverley M.; Cohen, Bruce N. et al. (2017) Reliable Identification of Living Dopaminergic Neurons in Midbrain Cultures Using RNA Sequencing and TH-promoter-driven eGFP Expression Journal of Visualized Experiments; No. 120; https://doi.org/10.3791/54981

• Kim, Jinho; Henley, Beverley M. et al. (2016) Incubator embedded cell culture imaging system (EmSight) based on Fourier ptychographic microscopy Biomedical Optics Express; Vol. 7; No. 8; https://doi.org/10.1364/BOE.7.003097

• Nichols, Weston A.; Henderson, Brandon J. et al. (2016) Mutation Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Reduces Low-Sensitivity α4β2, and Increases α5α4β2, Nicotinic Receptor Surface Expression PLoS ONE; Vol. 11; No. 6; https://doi.org/10.1371/journal.pone.0158032

• Henderson, Brandon J.; Wall, Teagan R. et al. (2016) Menthol Alone Upregulates Midbrain nAChRs, Alters nAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward Journal of Neuroscience; Vol. 36; No. 10; https://doi.org/10.1523/JNEUROSCI.4194-15.2016

• Post, Michael R.; Lester, Henry et al. (2016) Probing binding interactions of agonists at a nicotinic acetylcholine receptor subtype important to addiction and Parkinson's disease In: 251st American Chemical Society National Meeting & Exposition, March 13-17, 2016, San Diego, CA https://resolver.caltech.edu/CaltechAUTHORS:20160414-084908996

• Patowary, Suparna; Mackey, Elisha D. W. et al. (2016) Effects of Menthol on α3β4∗ Nicotinic Receptors Biophysical Journal; Vol. 110; No. 3; In: 60th Annual Meeting of the Biophysical-Society, February 27-March 2, 2016, Los Angeles, CA https://doi.org/10.1016/j.bpj.2015.11.3221

• Post, Michael R.; Dougherty, Dennis A. et al. (2016) Probing Binding Interactions of Agonists with the α6β2 Nicotinic Acetylcholine Receptor Biophysical Journal; Vol. 110; No. 3; In: 60th Annual Meeting of the Biophysical-Society, February 27-March 2, 2016, Los Angeles, CA https://doi.org/10.1016/j.bpj.2015.11.3220

• Srinivasan, Rahul; Henley, Beverley M. et al. (2016) Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons Journal of Neuroscience; Vol. 36; No. 1; https://doi.org/10.1523/JNEUROSCI.2126-15.2016

• Lester, Henry A.; Lavis, Luke D. et al. (2015) Ketamine Inside Neurons? American Journal of Psychiatry; Vol. 172; No. 11; https://doi.org/10.1176/appi.ajp.2015.14121537

• Post, Michael R.; Limapichat, Walrati et al. (2015) Heterologous expression and nonsense suppression provide insights into agonist behavior at α6β2 nicotinic acetylcholine receptors Neuropharmacology; Vol. 97; https://doi.org/10.1016/j.neuropharm.2015.04.009

• Henderson, Brandon J.; Lester, Henry A. (2015) Inside-out neuropharmacology of nicotinic drugs Neuropharmacology; Vol. 96; https://doi.org/10.1016/j.neuropharm.2015.01.022

• Sinkus, Melissa L.; Graw, Sharon et al. (2015) The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function Neuropharmacology; Vol. 96; https://doi.org/10.1016/j.neuropharm.2015.02.006

• Marotta, Christopher B.; Lester, Henry A. et al. (2015) An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7 Nicotinic Acetylcholine Receptors Chemistry and Biology; Vol. 22; No. 8; https://doi.org/10.1016/j.chembiol.2015.06.018

• Wieskopf, Jeffrey S.; Limapichat, Walrati et al. (2015) The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors Science Translational Medicine; Vol. 7; No. 287; https://doi.org/10.1126/scitranslmed.3009986

• Miles, Timothy F.; Lester, Henry A. et al. (2015) Allosteric activation of the 5-HT_3AB receptor by mCPBG Neuropharmacology; Vol. 91; https://doi.org/10.1016/j.neuropharm.2014.12.018

• Xiao, Cheng; Miwa, Julie M. et al. (2015) Nicotinic Receptor Subtype-Selective Circuit Patterns in the Subthalamic Nucleus Journal of Neuroscience; Vol. 35; No. 9; https://doi.org/10.1523/JNEUROSCI.3528-14.2015

• Nichols, Weston A.; Henderson, Brandon J. et al. (2014) Lynx1 Shifts α4β2 Nicotinic Receptor Subunit Stoichiometry by Affecting Assembly in the Endoplasmic Reticulum Journal of Biological Chemistry; Vol. 289; No. 45; https://doi.org/10.1074/jbc.M114.573667

• Daeffler, Kristina N.-M.; Lester, Henry A. et al. (2014) Functional Evaluation of Key Interactions Evident in the Structure of the Eukaryotic Cys-Loop Receptor GluCl ACS Chemical Biology; Vol. 9; No. 10; https://doi.org/10.1021/cb500323d

• Wang, Ying; Xiao, Cheng et al. (2014) The duplicated α7 subunits assemble and form functional nicotinic receptors with the full-length α7 Journal of Biological Chemistry; Vol. 289; No. 38; https://doi.org/10.1074/jbc.M114.582858

• Limapichat, Walrati; Dougherty, Dennis A. et al. (2014) Subtype-Specific Mechanisms for Functional Interaction between α6β4* Nicotinic Acetylcholine Receptors and P2X Receptors Molecular Pharmacology; Vol. 86; No. 3; https://doi.org/10.1124/mol.114.093179

• Kobayashi, Atsuko; Parker, Rell L. et al. (2014) lynx1 Supports Neuronal Health in the Mouse Dorsal Striatum During Aging: an Ultrastructural Investigation Journal of Molecular Neuroscience; Vol. 53; No. 3; In: 14th International Symposium on Cholinergic Mechanisms (ISCM), May 2013, Hangzhou, China https://doi.org/10.1007/s12031-014-0352-1

• Shih, Pei-Yu; Engle, Staci E. et al. (2014) Differential Expression and Function of Nicotinic Acetylcholine Receptors in Subdivisions of Medial Habenula Journal of Neuroscience; Vol. 34; No. 29; https://doi.org/10.1523/JNEUROSCI.0476-14.2014

• Marotta, Christopher B.; Rreza, Iva et al. (2014) Selective Ligand Behaviors Provide New Insights into Agonist Activation of Nicotinic Acetylcholine Receptors ACS Chemical Biology; Vol. 9; No. 5; https://doi.org/10.1021/cb400937d

• Srinivasan, Rahul; Henderson, Brandon J. et al. (2014) Pharmacological chaperoning of nAChRs: A therapeutic target for Parkinson's disease Pharmacological Research; Vol. 83; https://doi.org/10.1016/j.phrs.2014.02.005

• Lester, Henry; Cohen, Bruce (2014) Drugs and the brain, the MOOC FASEB Journal; Vol. 28; No. 1; In: 2014 Experimental Biology Meeting, April 26-30, 2014, San Diego, CA https://resolver.caltech.edu/CaltechAUTHORS:20150205-130837428

• Marotta, Christopher B.; Dilworth, Crystal N. et al. (2014) Probing the non-canonical interface for agonist interaction with an α5 containing nicotinic acetylcholine receptor Neuropharmacology; Vol. 77; https://doi.org/10.1016/j.neuropharm.2013.09.028

• Marotta, Christopher; Lester, Henry A. et al. (2014) Identifying Motifs Essential for Selective Activation of Nicotinic Acetylcholine Receptors Biophysical Journal; Vol. 106; No. 2; In: 58th Annual Meeting of the Biophysical-Society, February 15-19, 2014, San Francisco, CA https://doi.org/10.1016/j.bpj.2013.11.1951

• Post, Michael R.; Lester, Henry A. et al. (2014) Structure Function Studies at Two Different Nicotinic Acetylcholine Receptor Subtypes Biophysical Journal; Vol. 106; No. 2; In: 58th Annual Meeting of the Biophysical-Society, February 15-19, 2014, San Francisco, CA https://doi.org/10.1016/j.bpj.2013.11.1950

• Lester, Henry (2014) Drug Actions on Nicotinic Receptors. Chronic vs Acute; Outside-in vs Inside-out Neuropsychopharmacology; Vol. 39; No. S1; In: American College of Neuropsychopharmacology (ACNP) 53rd Annual Meeting, December 7-11, 2014, Phoenix, AZ https://resolver.caltech.edu/CaltechAUTHORS:20150108-114406249

• Henderson, Brandon J.; Srinivasan, Rahul et al. (2013) Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors Journal of General Physiology; Vol. 143; No. 1; https://doi.org/10.1085/jgp.201311102

• Henley, Beverley M.; Williams, Brian A. et al. (2013) Transcriptional regulation by nicotine in dopaminergic neurons Biochemical Pharmacology; Vol. 86; No. 8; https://doi.org/10.1016/j.bcp.2013.07.031

• Miles, Timothy F.; Dougherty, Dennis A. et al. (2013) The 5-HT_3AB Receptor Shows an A_3B_2 Stoichiometry at the Plasma Membrane Biophysical Journal; Vol. 105; No. 4; https://doi.org/10.1016/j.bpj.2013.07.015

• Van Arnam, Ethan B.; Blythe, Emily E. et al. (2013) An Unusual Pattern of Ligand-Receptor Interactions for the α7 Nicotinic Acetylcholine Receptor, with Implications for the Binding of Varenicline Molecular Pharmacology; Vol. 84; No. 2; https://doi.org/10.1124/mol.113.085795

• Frazier, Shawnalea J.; Cohen, Bruce N. et al. (2013) An Engineered Glutamate-gated Chloride (GluCl) Channel for Sensitive, Consistent Neuronal Silencing by Ivermectin Journal of Biological Chemistry; Vol. 288; No. 29; https://doi.org/10.1074/jbc.M112.423921

• Chatterjee, Susmita; Santos, Nathan et al. (2013) The α5 Subunit Regulates the Expression and Function of α4*-Containing Neuronal Nicotinic Acetylcholine Receptors in the Ventral-Tegmental Area PLoS ONE; Vol. 8; No. 7; https://doi.org/10.1371/journal.pone.0068300

• Blum, Angela P.; Van Arnam, Ethan B. et al. (2013) Binding Interactions with the Complementary Subunit of Nicotinic Receptors Journal of Biological Chemistry; Vol. 288; No. 10; https://doi.org/10.1074/jbc.M112.439968

• Limapichat, Walrati; Yu, Wesley Y. et al. (2013) Key Binding Interactions for Memantine in the NMDA Receptor ACS Chemical Neuroscience; Vol. 4; No. 2; https://doi.org/10.1021/cn300180a

• O'Neill, Heidi C.; Laverty, Duncan C. et al. (2013) Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function Pharmacology Biochemistry and Behavior; Vol. 103; No. 3; https://doi.org/10.1016/j.pbb.2012.10.014

• Lester, Henry A.; Miwa, Julie M. et al. (2012) Psychiatric Drugs Bind to Classical Targets Within Early Exocytotic Pathways: Therapeutic Effects Biological Psychiatry; Vol. 72; No. 11; https://doi.org/10.1016/j.biopsych.2012.05.020

• Miles, Timothy F.; Bower, Kiowa S. et al. (2012) A Coupled Array of Noncovalent Interactions Impacts the Function of the 5‑HT_3A Serotonin Receptor in an Agonist-Specific Way ACS Chemical Neuroscience; Vol. 3; No. 10; https://doi.org/10.1021/cn3000586

• Scott, Kimberly M.; Du, Jiangang et al. (2012) Variability of acute extracellular action potential measurements with multisite silicon probes Journal of Neuroscience Methods; Vol. 211; No. 1; https://doi.org/10.1016/j.jneumeth.2012.08.005

• Drenan, Ryan M.; Lester, Henry A. (2012) Insights into the Neurobiology of the Nicotinic Cholinergic System and Nicotine Addiction from Mice Expressing Nicotinic Receptors Harboring Gain-of-Function Mutations Pharmacological Reviews; Vol. 64; No. 4; https://doi.org/10.1124/pr.111.004671

• Duffy, Noah H.; Lester, Henry A. et al. (2012) Ondansetron and Granisetron Binding Orientation in the 5‑HT_3 Receptor Determined by Unnatural Amino Acid Mutagenesis ACS Chemical Biology; Vol. 7; No. 10; https://doi.org/10.1021/cb300246j

• Daeffler, Kristina N.-M.; Lester, Henry A. et al. (2012) Functionally Important Aromatic–Aromatic and Sulfur−π Interactions in the D2 Dopamine Receptor Journal of the American Chemical Society; Vol. 134; No. 36; https://doi.org/10.1021/ja304560x

• Liu, Cambrian Y.; Xiao, Cheng et al. (2012) Electrophysiological characterization of Grueneberg ganglion olfactory neurons: spontaneous firing, sodium conductance, and hyperpolarization-activated currents Journal of Neurophysiology; Vol. 108; No. 5; https://resolver.caltech.edu/CaltechAUTHORS:20120910-073630839

• Shapiro, Mikhail G.; Frazier, Shawnalea J. et al. (2012) Unparalleled Control of Neural Activity Using Orthogonal Pharmacogenetics ACS Chemical Neuroscience; Vol. 3; No. 8; https://doi.org/10.1021/cn300053q

• Miwa, Julie M.; Lester, Henry A. et al. (2012) Optimizing Cholinergic Tone Through Lynx Modulators of Nicotinic Receptors: Implications for Plasticity and Nicotine Addiction Physiology; Vol. 27; No. 4; https://doi.org/10.1152/physiol.00002.2012

• Srinivasan, Rahul; Richards, Christopher I. et al. (2012) Förster Resonance Energy Transfer (FRET) Correlates of Altered Subunit Stoichiometry in Cys-Loop Receptors, Exemplified by Nicotinic α4β2 International Journal of Molecular Sciences; Vol. 13; No. 8; https://doi.org/10.3390/ijms130810022

• Mackey, Elisha D. W.; Engle, Staci E. et al. (2012) α6* Nicotinic Acetylcholine Receptor Expression and Function in a Visual Salience Circuit Journal of Neuroscience; Vol. 32; No. 30; https://doi.org/10.1523/JNEUROSCI.0007-12.2012

• Tavares, Ximena Da Silva; Blum, Angela P. et al. (2012) Variations in Binding Among Several Agonists at Two Stoichiometries of the Neuronal, α4β2 Nicotinic Receptor Journal of the American Chemical Society; Vol. 134; No. 28; https://doi.org/10.1021/ja3011379

• Richards, Christopher I.; Luong, Khai et al. (2012) Live-Cell Imaging of Single Receptor Composition Using Zero-Mode Waveguide Nanostructures Nano Letters; Vol. 12; No. 7; https://doi.org/10.1021/nl301480h

• Puskar, Nyssa L.; Lester, Henry A. et al. (2012) Probing the Effects of Residues Located Outside the Agonist Binding Site on Drug-Receptor Selectivity in the Nicotinic Receptor ACS Chemical Biology; Vol. 7; No. 5; https://doi.org/10.1021/cb200448j

• Srinivasan, Rahul; Richards, Christopher I. et al. (2012) Pharmacological Chaperoning of Nicotinic Acetylcholine Receptors Reduces the Endoplasmic Reticulum Stress Response Molecular Pharmacology; Vol. 81; No. 6; https://doi.org/10.1124/mol.112.077792

• Murray, Teresa A.; Bertrand, Daniel et al. (2012) α7β2 Nicotinic Acetylcholine Receptors Assemble, Function, and Are Activated Primarily via Their α7-α7 Interfaces Molecular Pharmacology; Vol. 81; No. 2; https://resolver.caltech.edu/CaltechAUTHORS:20120214-145000544

• Cohen, B. N.; Mackey, E. D. W. et al. (2012) Nicotinic cholinergic mechanisms causing elevated dopamine release and abnormal locomotor behavior Neuroscience; Vol. 200; https://doi.org/10.1016/j.neuroscience.2011.10.047

• Xiao, Cheng; Srinivasan, Rahul et al. (2011) Characterizing functional α6β2 nicotinic acetylcholine receptors in vitro: Mutant β2 subunits improve membrane expression, and fluorescent proteins reveal responsive cells Biochemical Pharmacology; Vol. 82; No. 8; https://doi.org/10.1016/j.bcp.2011.05.005

• Du, Jiangang; Blanche, Timothy J. et al. (2011) Multiplexed, High Density Electrophysiology with Nanofabricated Neural Probes PLoS ONE; Vol. 6; No. 10; https://doi.org/10.1371/journal.pone.0026204

• Xu, J.; Cohen, B. N. et al. (2011) Altered activity–rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the β2 nicotinic receptor Molecular Psychiatry; Vol. 16; No. 10; https://doi.org/10.1038/mp.2010.78

• Van Arnam, Ethan B.; Lester, Henry A. et al. (2011) Dissecting the Functions of Conserved Prolines within Transmembrane Helices of the D2 Dopamine Receptor ACS Chemical Biology; Vol. 6; No. 10; https://doi.org/10.1021/cb200153g

• Lummis, S. C. R.; Thompson, A. J. et al. (2011) Varenicline Is a Potent Agonist of the Human 5-Hydroxytryptamine_3 Receptor Journal of Pharmacology and Experimental Therapeutics; Vol. 339; No. 1; https://doi.org/10.1124/jpet.111.185306

• Blum, Angela P.; Gleitsman, Kristin Rule et al. (2011) Evidence for an Extended Hydrogen Bond Network in the Binding Site of the Nicotinic Receptor: Role of the Vicinal Disulfide of the α1 Subunit Journal of Biological Chemistry; Vol. 286; No. 37; https://doi.org/10.1074/jbc.M111.254235

• Richards, Christopher I.; Srinivasan, Rahul et al. (2011) Trafficking of α4^* Nicotinic Receptors Revealed by Superecliptic Phluorin Journal of Biological Chemistry; Vol. 286; No. 36; https://doi.org/10.1074/jbc.M111.256024

• Puskar, Nyssa L.; Xiu, Xinan et al. (2011) Two Neuronal Nicotinic Acetylcholine Receptors, α4β4 and α7, Show Differential Agonist Binding Modes Journal of Biological Chemistry; Vol. 286; No. 16; https://doi.org/10.1074/jbc.M110.206565

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• Fong, Tung Ming; Davidson, Norman et al. (1989) Further evidence demonstrating that N-methyl-D-aspartate and kainate activate distinct ion channels Synapse; Vol. 4; No. 1; https://doi.org/10.1002/syn.890040110

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• Lester, Henry A. (1988) Heterologous Expression of Excitability Proteins: Route to More Specific Drugs? Science; Vol. 241; No. 4869; https://doi.org/10.1126/science.2457947

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• Lester, H. A.; Snutch, T. P. et al. (1988) Expression of mRNA Encoding Rat Brain Ca²⁺ Channels in Xenopus Oocytes In: The Calcium Channel: Structure, Function and Implications; Series Bayer AG Centenary Symposium; In: Bayer AG Centenary Symposium, 11-14 May 1988, Stresa, Italy https://doi.org/10.1007/978-3-642-73914-9_22

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• Lübbert, Hermann; Hoffman, Beth J. et al. (1987) cDNA Cloning of a Serotonin 5-HT1C Receptor by Electrophysiological Assays of mRNA-Injected Xenopus Oocytes Proceedings of the National Academy of Sciences of the United States of America; Vol. 84; No. 12; https://resolver.caltech.edu/CaltechAUTHORS:LUBpnas87

• Gurney, Alison M.; Tsien, Roger Y. et al. (1987) Activation of a Potassium Current by Rapid Photochemically Generated Step Increases of Intracellular Calcium in Rat Sympathetic Neurons Proceedings of the National Academy of Sciences of the United States of America; Vol. 84; No. 10; https://resolver.caltech.edu/CaltechAUTHORS:GURpnas87

• Gurney, Alison M.; Lester, Henry A. (1987) Light-flash physiology with synthetic photosensitive compounds Physiological Reviews; Vol. 67; No. 2; https://doi.org/10.1152/physrev.1987.67.2.583

• Lübbert, Hermann; Snutch, Terry P. et al. (1987) Rat brain 5-HT_(1C) receptors are encoded by a 5-6 kbase mRNA size class and are functionally expressed in injected Xenopus oocytes Journal of Neuroscience; Vol. 7; No. 4; https://doi.org/10.1523/jneurosci.07-04-01159.1987

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• Snutch, Terry P.; Leonard, John P. et al. (1987) Characterization of voltage-gated calcium channels in Xenopus oocytes after injection of RNA from electrically excitable tissues Society of General Physiologists series; Vol. 42; https://resolver.caltech.edu/CaltechAUTHORS:20201009-153923021

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• Chabala, Lee D.; Lester, Henry A. (1986) Activation of acetylcholine receptor channels by covalently bound agonists in cultured rat myoballs Journal of Physiology; Vol. 379; No. 1; https://doi.org/10.1113/jphysiol.1986.sp016242

• Goldin, Alan L.; Snutch, Terry P. et al. (1986) Messenger RNA coding for only the alpha subunit of the rat brain Na channel is sufficient for expression of functional channels in Xenopus oocytes Proceedings of the National Academy of Sciences of the United States of America; Vol. 83; No. 19; https://resolver.caltech.edu/CaltechAUTHORS:GOLpnas86

• Dascal, Nathan; Snutch, Terry P. et al. (1986) Expression and modulation of voltage-gated calcium channels after RNA injection in Xenopus oocytes Science; Vol. 231; No. 4742; https://doi.org/10.1126/science.2418503

• Chabala, Lee D.; Gurney, Alison M. et al. (1986) Dose-response of acetylcholine receptor channels opened by a flash-activated agonist in voltage-clamped rat myoballs Journal of Physiology; Vol. 371; No. 1; https://doi.org/10.1113/jphysiol.1986.sp015983

• Dascal, Nathan; Lotan, Ilana et al. (1985) Acetylcholine and phorbol esters inhibit potassium currents evoked by adenosine and cAMP in Xenopus oocytes Proceedings of the National Academy of Sciences of the United States of America; Vol. 82; No. 17; https://resolver.caltech.edu/CaltechAUTHORS:DASpnas85

• Gurney, Alison M.; Nerbonne, Jeanne M. et al. (1985) Photoinduced Removal of Nifedipine Reveals Mechanisms of Calcium Antagonist Action on Single Heart Cells Journal of General Physiology; Vol. 86; No. 3; https://doi.org/10.1085/jgp.86.3.353

• Krouse, Mauri E.; Lester, Henry A. et al. (1985) Rates and Equilibria for a Photoisomerizable Antagonist at the Acetylcholine Receptor of Electrophorus Electroplaques Journal of General Physiology; Vol. 86; No. 2; https://doi.org/10.1085/jgp.86.2.235

• Chabala, Lee D.; Gurney, Alison M. et al. (1985) Photoactivation and dissociation of agonist molecules at the nicotinic acetylcholine receptor in voltage-clamped rat myoballs Biophysical Journal; Vol. 48; No. 2; https://doi.org/10.1016/s0006-3495(85)83777-2

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• Richard, Sylvain; Nerbonne, Jeanne M. et al. (1985) Photochemically produced intracellular concentration jumps of cAMP mimic the effects of catecholamines on excitation-contraction coupling in frog atrial fibers Pflügers Archiv European Journal of Physiology; Vol. 403; No. 3; https://doi.org/10.1007/bf00583606

• Kegel, Daniel R.; Wolf, Benjamin D. et al. (1985) Software for electrophysiological experiments with a personal computer Journal of Neuroscience Methods; Vol. 12; No. 4; https://doi.org/10.1016/0165-0270(85)90016-0

• Nerbonne, Jeanne M.; Richard, Sylvain et al. (1984) New photoactivatable cyclic nucleotides produce intracellular jumps in cyclic AMP and cyclic GMP concentrations Nature; Vol. 310; No. 5972; https://doi.org/10.1038/310074a0

• Nargeot, Joel; Nerbonne, Jeanne M. et al. (1983) Time Course of the Increase in the Myocardial Slow Inward Current after a Photochemically Generated Concentration Jump of Intracellular cAMP Proceedings of the National Academy of Sciences of the United States of America; Vol. 80; No. 8; https://resolver.caltech.edu/CaltechAUTHORS:NARpnas83

• Nerbonne, Jeanne M.; Sheridan, Robert E. et al. (1983) cis-3,3'-Bis-[α-(trimethylammonium)methyl]azobenzene (cis-Bis-Q). Purification and properties at acetylcholine receptors of Electrophorus electroplaques Molecular pharmacology; Vol. 23; No. 2; https://resolver.caltech.edu/CaltechAUTHORS:20201012-160244665

• Braun, Sergei; Tolkovsky, Aviva M. et al. (1982) Activation and inhibition of adenylate cyclase by hormones Biochemical Society Transactions; Vol. 10; No. 6; https://doi.org/10.1042/bst0100496

• Sheridan, Robert E.; Lester, Henry A. (1982) Functional Stoichiometry at the Nicotinic Receptor. The Photon Cross Section for Phase 1 Corresponds to Two Bis-Q Molecules per Channel Journal of General Physiology; Vol. 80; No. 4; https://doi.org/10.1085/jgp.80.4.499

• Lester, Henry A.; Nerbonne, Jeanne M. (1982) Physiological and Pharmacological Manipulations with Light Flashes Annual Review of Biophysics and Bioengineering; Vol. 11; https://doi.org/10.1146/annurev.bb.11.060182.001055

• Nargeot, Joel; Lester, Henry A. et al. (1982) A photoisomerizable muscarinic antagonist. Studies of binding and of conductance relaxations in frog heart Journal of General Physiology; Vol. 79; No. 4; https://doi.org/10.1085/jgp.79.4.657

• Lester, Henry A.; Steer, Michael L. et al. (1982) ADP-Ribosylation of Membrane Proteins in Cholinergic Nerve Terminals Journal of Neurochemistry; Vol. 38; No. 4; https://doi.org/10.1111/j.1471-4159.1982.tb05351.x

• Lester, Henry A.; Steer, Michael L. et al. (1982) Prostaglandin-Stimulated GTP Hydrolysis Associated with Activation of Adenylate Cyclase in Human Platelet Membranes Proceedings of the National Academy of Sciences of the United States of America; Vol. 79; No. 3; https://resolver.caltech.edu/CaltechAUTHORS:LESpnas82

• Steer, M. L.; Braun, S. et al. (1982) Activation of adenylate cyclase from purified platelet membranes by prostaglandin E1 and its inhibition by L-epinephrine: mechanistic effects Journal of Cyclic Nucleotide Research; Vol. 8; No. 5; https://resolver.caltech.edu/CaltechAUTHORS:20201009-153010808

• Lester, Henry A. (1981) A potpourri of plucked patches Nature; Vol. 294; No. 5840; https://doi.org/10.1038/294398a0

• Lester, Henry A.; Nass, Menasche M. et al. (1980) Electrophysiological Experiments With Photoisomerizable Cholinergic Compounds: Review and Progress Report Annals of the New York Academy of Sciences; Vol. 346; https://doi.org/10.1111/j.1749-6632.1980.tb22118.x

• Lester, Henry A.; Krouse, Mauri E. et al. (1980) A covalently bound photoisomerizable agonist. Comparison with reversibly bound agonists at electrophorus electroplaques Journal of General Physiology; Vol. 75; No. 2; https://doi.org/10.1085/jgp.75.2.207

• Armstrong, David L.; Lester, Henry A. (1979) The kinetics of tubocurarine action and restricted diffusion within the synaptic cleft Journal of Physiology; Vol. 294; No. 1; https://doi.org/10.1113/jphysiol.1979.sp012935

• Lester, Henry A.; Krouse, Mauri E. et al. (1979) Light-activated drug confirms a mechanism of ion channel blockade Nature; Vol. 280; No. 5722; https://doi.org/10.1038/280509a0

• Wathey, John C.; Nass, Menasche M. et al. (1979) Numerical reconstruction of the quantal event at nicotinic synapses Biophysical Journal; Vol. 27; No. 1; https://doi.org/10.1016/s0006-3495(79)85208-x

• Koblin, Donald D.; Lester, Henry A. (1979) Voltage-dependent and voltage-independent blockade of acetylcholine receptors by local anesthetics in Electrophorus electroplaques Molecular Pharmacology; Vol. 15; No. 3; https://resolver.caltech.edu/CaltechAUTHORS:20201005-113630529

• Lester, Henry A. (1978) Analysis of sodium and potassium redistribution during sustained permeability increases at the innervated face of Electrophorus electroplaques Journal of General Physiology; Vol. 72; No. 6; https://doi.org/10.1085/jgp.72.6.847

• Nass, Menasche M.; Lester, Henry A. et al. (1978) Response of acetylcholine receptors to photoisomerizations of bound agonist molecules Biophysical Journal; Vol. 24; No. 1; https://doi.org/10.1016/s0006-3495(78)85352-1

• Lester, Henry A.; Koblin, Donald D. et al. (1978) Role of voltage-sensitive receptors in nicotinic transmission Biophysical Journal; Vol. 21; No. 3; https://doi.org/10.1016/s0006-3495(78)85518-0

• Sheridan, Robert E.; Lester, Henry A. (1977) Rates and equilibria at the acetylcholine receptor of electrophorus electroplaques. A study of neurally evoked postsynaptic currents and of voltage-jump relaxations Journal of General Physiology; Vol. 70; No. 2; https://doi.org/10.1085/jgp.70.2.187

• Lester, Henry A.; Chang, Hai Won (1977) Response of acetylcholine receptors to rapid photochemically produced increases in agonist concentration Nature; Vol. 266; No. 5600; https://doi.org/10.1038/266373a0

• Lester, Henry A. (1977) The response to acetylcholine Scientific American; Vol. 236; No. 2; https://doi.org/10.1038/scientificamerican0277-106

• Sheridan, Robert E.; Lester, Henry A. (1975) Relaxation measurements on the acetylcholine receptor Proceedings of the National Academy of Sciences of the United States of America; Vol. 72; No. 9; https://doi.org/10.1073/pnas.72.9.3496

• Lester, Henry A.; Changeux, Jean-Pierre et al. (1975) Conductance increases produced by bath application of cholinergic agonists to Electrophorus electroplaques Journal of General Physiology; Vol. 65; No. 6; https://doi.org/10.1085/jgp.65.6.797

• Lester, H. A. (1972) Blockade of acetylcholine receptors by cobra toxin: electrophysiological studies Molecular Pharmacology; Vol. 8; No. 6; https://resolver.caltech.edu/CaltechAUTHORS:20201005-113628628

• Lester, H. A. (1972) Vulnerability of desensitized or curare-treated acetylcholine receptors to irreversible blockade by cobra toxin Molecular Pharmacology; Vol. 8; No. 6; https://resolver.caltech.edu/CaltechAUTHORS:20201005-113629507

• Lester, Henry A. (1970) Postsynaptic Action of Cobra Toxin at the Myoneural Junction Nature; Vol. 227; No. 5259; https://doi.org/10.1038/227727a0

• Lester, Henry A. (1970) Transmitter Release by Presynaptic Impulses in the Squid Stellate Ganglion Nature; Vol. 227; No. 5257; https://doi.org/10.1038/227493a0