Lester, Henry A.

Combined from CaltechAUTHORS

• Haloi, Nandan and Huang, Shan, et el. (2024) Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids; Protein Engineering, Design and Selection; Vol. 37; gzae003; 10.1093/protein/gzae003
• Blumenfeld, Zack and Bera, Kallol, et el. (2023) Antidepressants enter cells, organelles, and membranes; Neuropsychopharmacology; 10.1038/s41386-023-01725-x
• Walker, Noah B. and Yan, Yijin, et el. (2023) β2 nAChR Activation on VTA DA Neurons Is Sufficient for Nicotine Reinforcement in Rats; eNeuro; Vol. 10; No. 5; Art. No. ENEURO.0449-22.2023; PMCID PMC10216253; 10.1523/eneuro.0449-22.2023
• Nichols, Aaron L. and Blumenfeld, Zack, et el. (2023) Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane; Journal of Neuroscience; Vol. 43; No. 13; 2222-2241; PMCID PMC10072302; 10.1523/jneurosci.1519-22.2022
• Haloi, Nandan and Huang, Shan, et el. (2023) Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids; 10.1101/2023.01.16.524298
• Knox, Hailey J. and Rego Campello, Hugo, et el. (2022) Characterization of Binding Site Interactions and Selectivity Principles in the α3β4 Nicotinic Acetylcholine Receptor; Journal of the American Chemical Society; Vol. 144; No. 35; 16101-16117; 10.1021/jacs.2c06495
• Harrison, Neil L. and Abbott, Geoffrey W., et el. (2022) How many SARS-CoV-2 "viroporins" are really ion channels?; Communications Biology; Vol. 5; No. 1; 10.1038/s42003-022-03669-2
• Nichols, Aaron L. and Blumenfeld, Zack, et el. (2022) Selective Serotonin Reuptake Inhibitors Within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane; 10.1101/2022.08.09.502705
• Muthusamy, Anand K. and Kim, Charlene H., et el. (2022) Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-Methadone for Use in Cells, Organelles, and Biofluids; Journal of the American Chemical Society; Vol. 144; No. 19; 8480-8486; PMCID PMC9121368; 10.1021/jacs.2c02323
• Nichols, Aaron L. and Blumenfeld, Zack, et el. (2022) Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands; eLife; Vol. 11; Art. No. e74648; PMCID PMC8820738; 10.7554/eLife.74648
• Mulcahy, Matthew J. and Huard, Stephanie M., et el. (2021) Protein profiling in the habenula after chronic (–)-menthol exposure in mice; Journal of Neurochemistry; Vol. 158; No. 6; 1345-1358; PMCID PMC8577691; 10.1111/jnc.15495
• Grant, Stephen N. and Lester, Henry A. (2021) Regulation of epithelial sodium channel activity by SARS-CoV-1 and SARS-CoV-2 proteins; Biophysical Journal; Vol. 120; No. 14; 2805-2813; PMCID PMC8238646; 10.1016/j.bpj.2021.06.005
• Unger, Elizabeth K. and Keller, Jacob P., et el. (2020) Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning; Cell; Vol. 183; No. 7; 1986-2002; PMCID PMC8025677; 10.1016/j.cell.2020.11.040
• Grant, Stephen and Lester, Henry A. (2020) Proteins for increased surface expression of the α6β4 nicotinic acetylcholine receptor: Nothing but good news?; Journal of Clinical Investigation; Vol. 130; No. 11; 5685-5687; PMCID PMC7598034; 10.1172/jci143197
• Cohen, Bruce N. and Nichols, Aaron L., et el. (2020) Successful Cessation Programs that Reduce Comorbidity May Explain Surprisingly Low Smoking Rates Among Hospitalized COVID-19 Patients; 10.32388/WURFH0
• Borden, Philip M. and Shivange, Amol V., et el. (2020) A fast genetically encoded fluorescent sensor for faithful in vivo acetylcholine detection in mice, fish, worms and flies; 10.1101/2020.02.07.939504
• Grant, Stephen and Muthusamy, Anand K., et el. (2020) Antagonists Pharmacologically Chaperone Opioid Receptors; Biophysical Journal; Vol. 118; No. 3; 27a; 10.1016/j.bpj.2019.11.328
• Mulcahy, Matthew J. and Huard, Stephanie M., et el. (2020) Brain Region-Specific nAChR and Associated Protein Abundance Alterations Following Chronic Nicotine and/or Menthol Exposure; Journal of Proteome Research; Vol. 19; No. 1; 36-48; PMCID PMC7289315; 10.1021/acs.jproteome.9b00286
• Bera, Kallol and Kamajaya, Aron, et el. (2019) Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum; Frontiers in Cellular Neuroscience; Vol. 13; Art. No. 499; PMCID PMC6874132; 10.3389/fncel.2019.00499
• Lester, Henry A. and Dougherty, Dennis A. (2019) Nicotine Bound to Its Receptors: New Structures for a Vexing Pathopharmacological Problem; Neuron; Vol. 104; No. 3; 431-432; 10.1016/j.neuron.2019.10.029
• Blom, Annet E. M. and Rego Campello, Hugo, et el. (2019) Probing Binding Interactions of Cytisine Derivatives to the α4β2 Nicotinic Acetylcholine Receptor; Journal of the American Chemical Society; Vol. 141; No. 40; 15840-15849; 10.1021/jacs.9b06580
• Shivange, Amol V. and Borden, Philip M., et el. (2019) Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors; Journal of General Physiology; Vol. 151; No. 6; 738-757; PMCID PMC6571994; 10.1085/jgp.201812201
• Bavan, Selvan and Kim, Charlene H., et el. (2019) Chronic menthol does not change stoichiometry or functional plasma membrane levels of mouse α3β4-containing nicotinic acetylcholine receptors; Molecular Pharmacology; Vol. 95; No. 4; 398-407; PMCID PMC6399576; 10.1124/mol.118.114769
• Zhou, Chunyi and Gu, Weixin, et el. (2019) Bidirectional dopamine modulation of excitatory and inhibitory synaptic inputs to subthalamic neuron subsets containing α4β2 or α7 nAChRs; Neuropharmacology; Vol. 148; 220-228; 10.1016/j.neuropharm.2019.01.015
• Henderson, Brandon J. and Grant, Stephen, et el. (2018) Menthol stereoisomers exhibit different effects on α4β2 nAChR upregulation and dopamine neuron spontaneous firing; eNeuro; Vol. 5; No. 6; Art. No. e0465-18.2018; PMCID PMC6325563; 10.1523/eneuro.0465-18.2018
• Nichols, Aaron L. and Noridomi, Kaori, et el. (2018) α1-FANGs: Protein Ligands Selective for the α-Bungarotoxin Site of the α1-Nicotinic Acetylcholine Receptor; ACS Chemical Biology; Vol. 13; No. 9; 2568-2576; PMCID PMC8763392; 10.1021/acschembio.8b00513
• Subramaniam, Sudhakar R. and Magen, Iddo, et el. (2018) Chronic nicotine improves cognitive and social impairment in mice overexpressing wild type α-synuclein; Neurobiology of Disease; Vol. 117; 170-180; PMCID PMC6051902; 10.1016/j.nbd.2018.05.018
• Banala, Sambashiva and Arvin, Matthew C., et el. (2018) Photoactivatable drugs for nicotinic optopharmacology; Nature Methods; Vol. 15; No. 5; 347-350; PMCID PMC5923430; 10.1038/nmeth.4637
• Muthusamy, Anand K. and Shivange, Amol V., et el. (2018) Microscopy Using Fluorescent Drug Biosensors for "Inside-Out Pharmacology"; Biophysical Journal; Vol. 114; No. 3; 358A; 10.1016/j.bpj.2017.11.1990
• Bavan, Selvan and Patowary, Suparna, et el. (2018) Effects of Chronic Menthol at Alpha3Beta4 (α3β4)-Containing Nicotinic Acetylcholine Receptors; Biophysical Journal; Vol. 114; No. 3; 296A; 10.1016/j.bpj.2017.11.1691
• Parker, Rell L. and O'Neill, Heidi C., et el. (2017) Deletion of lynx1 reduces the function of α6* nicotinic receptors; PLoS ONE; Vol. 12; No. 12; Art. No. e0188715; PMCID PMC5716591; 10.1371/journal.pone.0188715
• Henderson, Brandon J. and Wall, Teagan R., et el. (2017) Menthol Enhances Nicotine Reward-Related Behavior by Potentiating Nicotine-Induced Changes in nAChR Function, nAChR Upregulation, and DA Neuron Excitability; Neuropsychopharmacology; Vol. 42; No. 12; 2285-2291; PMCID PMC5645749; 10.1038/npp.2017.72
• Tarren, Josephine R. and Lester, Henry A., et el. (2017) Acute Ethanol Administration Upregulates Synaptic α4-Subunit of Neuronal Nicotinic Acetylcholine Receptors within the Nucleus Accumbens and Amygdala; Frontiers in Molecular Neuroscience; Vol. 10; Art. No. 338; PMCID PMC5660714; 10.3389/fnmol.2017.00338
• Shivange, Amol V. and Nichols, Aaron L., et el. (2017) Nicotine in the Endoplasmic Reticulum; Journal of General Physiology; Vol. 149; No. 9; Art. No. 32; 10.1085/jgp.149.9.889
• Wall, Teagan R. and Henderson, Brandon J., et el. (2017) TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors; Frontiers in Pharmacology; Vol. 8; Art. No. 641; PMCID PMC5626944; 10.3389/fphar.2017.00641
• Mulcahy, Matthew J. and Lester, Henry A. (2017) Granulocytes as models for human protein marker identification following nicotine exposure; Journal of Neurochemistry; Vol. 142; No. S2; 151-161; PMCID PMC6057152; 10.1111/jnc.14010
• Hurtado-Zavala, Joaquin I. and Ramachandran, Binu, et el. (2017) TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus; Nature Communications; Vol. 8; Art. No. 15878; PMCID PMC5524938; 10.1038/ncomms15878
• Kim, Jinho and Henley, Beverley M., et el. (2017) Incubator embedded cell culture imaging system (EmSight) based on Fourier ptychographic microscopy; ISBN 9781510605770; Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV; Art. No. 100680X; 10.1117/12.2249906
• Post, Michael R. and Lester, Henry A., et el. (2017) Probing for and Quantifying Agonist Hydrogen Bonds in α6β2 Nicotinic Acetylcholine Receptors; Biochemistry; Vol. 56; No. 13; 1836-1840; PMCID PMC6075822; 10.1021/acs.biochem.7b00213
• Mulcahy, Matthew J. and Wang, Jonathan H., et el. (2017) Region specific proteomic analysis of murine brain after chronic nicotine or menthol; FASEB Journal; Vol. 31; No. S1; Art. No. 991.1
• Post, Michael R. and Tender, Gabrielle S., et el. (2017) Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors; eNeuro; Vol. 4; No. 2; Art. No. 0032-17; PMCID PMC5458768; 10.1523/ENEURO.0032-17.2017
• Henley, Beverley M. and Cohen, Bruce N., et el. (2017) Reliable Identification of Living Dopaminergic Neurons in Midbrain Cultures Using RNA Sequencing and TH-promoter-driven eGFP Expression; Journal of Visualized Experiments; No. 120; Art. No. 54981; PMCID PMC5409190; 10.3791/54981
• Kim, Jinho and Henley, Beverley M., et el. (2016) Incubator embedded cell culture imaging system (EmSight) based on Fourier ptychographic microscopy; Biomedical Optics Express; Vol. 7; No. 8; 3097-3110; PMCID PMC4986817; 10.1364/BOE.7.003097
• Nichols, Weston A. and Henderson, Brandon J., et el. (2016) Mutation Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Reduces Low-Sensitivity α4β2, and Increases α5α4β2, Nicotinic Receptor Surface Expression; PLoS ONE; Vol. 11; No. 6; Art. No. e0158032; PMCID PMC4918917; 10.1371/journal.pone.0158032
• Henderson, Brandon J. and Wall, Teagan R., et el. (2016) Menthol Alone Upregulates Midbrain nAChRs, Alters nAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward; Journal of Neuroscience; Vol. 36; No. 10; 2957-2974; PMCID PMC4783498; 10.1523/JNEUROSCI.4194-15.2016
• Post, Michael R. and Lester, Henry, et el. (2016) Probing binding interactions of agonists at a nicotinic acetylcholine receptor subtype important to addiction and Parkinson's disease
• Patowary, Suparna and Mackey, Elisha D. W., et el. (2016) Effects of Menthol on α3β4∗ Nicotinic Receptors; Biophysical Journal; Vol. 110; No. 3; 603A; 10.1016/j.bpj.2015.11.3221
• Post, Michael R. and Dougherty, Dennis A., et el. (2016) Probing Binding Interactions of Agonists with the α6β2 Nicotinic Acetylcholine Receptor; Biophysical Journal; Vol. 110; No. 3; 603A; 10.1016/j.bpj.2015.11.3220
• Srinivasan, Rahul and Henley, Beverley M., et el. (2016) Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons; Journal of Neuroscience; Vol. 36; No. 1; 65-79; PMCID PMC4701966; 10.1523/JNEUROSCI.2126-15.2016
• Lester, Henry A. and Lavis, Luke D., et el. (2015) Ketamine Inside Neurons?; American Journal of Psychiatry; Vol. 172; No. 11; 1064-1066; PMCID PMC6107348; 10.1176/appi.ajp.2015.14121537
• Post, Michael R. and Limapichat, Walrati, et el. (2015) Heterologous expression and nonsense suppression provide insights into agonist behavior at α6β2 nicotinic acetylcholine receptors; Neuropharmacology; Vol. 97; 376-382; PMCID PMC4635625; 10.1016/j.neuropharm.2015.04.009
• Sinkus, Melissa L. and Graw, Sharon, et el. (2015) The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function; Neuropharmacology; Vol. 96; 274-288; PMCID PMC4486515; 10.1016/j.neuropharm.2015.02.006
• Henderson, Brandon J. and Lester, Henry A. (2015) Inside-out neuropharmacology of nicotinic drugs; Neuropharmacology; Vol. 96; 178-193; PMCID PMC4486611; 10.1016/j.neuropharm.2015.01.022
• Marotta, Christopher B. and Lester, Henry A., et el. (2015) An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7 Nicotinic Acetylcholine Receptors; Chemistry and Biology; Vol. 22; No. 8; 1063-1073; PMCID PMC4547686; 10.1016/j.chembiol.2015.06.018
• Wieskopf, Jeffrey S. and Limapichat, Walrati, et el. (2015) The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors; Science Translational Medicine; Vol. 7; No. 287; Art. No. 287ra72; PMCID PMC5018401; 10.1126/scitranslmed.3009986
• Miles, Timothy F. and Lester, Henry A., et el. (2015) Allosteric activation of the 5-HT_3AB receptor by mCPBG; Neuropharmacology; Vol. 91; 103-108; PMCID PMC4312754; 10.1016/j.neuropharm.2014.12.018
• Xiao, Cheng and Miwa, Julie M., et el. (2015) Nicotinic Receptor Subtype-Selective Circuit Patterns in the Subthalamic Nucleus; Journal of Neuroscience; Vol. 35; No. 9; 3734-3746; PMCID PMC4348180; 10.1523/JNEUROSCI.3528-14.2015
• Nichols, Weston A. and Henderson, Brandon J., et el. (2014) Lynx1 Shifts α4β2 Nicotinic Receptor Subunit Stoichiometry by Affecting Assembly in the Endoplasmic Reticulum; Journal of Biological Chemistry; Vol. 289; No. 45; 31423-31432; PMCID PMC4223341; 10.1074/jbc.M114.573667
• Daeffler, Kristina N.-M. and Lester, Henry A., et el. (2014) Functional Evaluation of Key Interactions Evident in the Structure of the Eukaryotic Cys-Loop Receptor GluCl; ACS Chemical Biology; Vol. 9; No. 10; 2283-2290; PMCID PMC4201344; 10.1021/cb500323d
• Wang, Ying and Xiao, Cheng, et el. (2014) The duplicated α7 subunits assemble and form functional nicotinic receptors with the full-length α7; Journal of Biological Chemistry; Vol. 289; No. 38; 26451-26463; PMCID PMC4176222; 10.1074/jbc.M114.582858
• Limapichat, Walrati and Dougherty, Dennis A., et el. (2014) Subtype-Specific Mechanisms for Functional Interaction between α6β4* Nicotinic Acetylcholine Receptors and P2X Receptors; Molecular Pharmacology; Vol. 86; No. 3; 263-274; PMCID PMC4152909; 10.1124/mol.114.093179
• Kobayashi, Atsuko and Parker, Rell L., et el. (2014) lynx1 Supports Neuronal Health in the Mouse Dorsal Striatum During Aging: an Ultrastructural Investigation; Journal of Molecular Neuroscience; Vol. 53; No. 3; 525-536; PMCID PMC4265479; 10.1007/s12031-014-0352-1
• Shih, Pei-Yu and Engle, Staci E., et el. (2014) Differential Expression and Function of Nicotinic Acetylcholine Receptors in Subdivisions of Medial Habenula; Journal of Neuroscience; Vol. 34; No. 29; 9789-9802; PMCID PMC4099552; 10.1523/JNEUROSCI.0476-14.2014
• Marotta, Christopher B. and Rreza, Iva, et el. (2014) Selective Ligand Behaviors Provide New Insights into Agonist Activation of Nicotinic Acetylcholine Receptors; ACS Chemical Biology; Vol. 9; No. 5; 1153-1159; PMCID PMC4033646; 10.1021/cb400937d
• Srinivasan, Rahul and Henderson, Brandon J., et el. (2014) Pharmacological chaperoning of nAChRs: A therapeutic target for Parkinson's disease; Pharmacological Research; Vol. 83; 20-29; PMCID PMC6075820; 10.1016/j.phrs.2014.02.005
• Lester, Henry and Cohen, Bruce (2014) Drugs and the brain, the MOOC; FASEB Journal; Vol. 28; No. 1; 221.2
• Marotta, Christopher B. and Dilworth, Crystal N., et el. (2014) Probing the non-canonical interface for agonist interaction with an α5 containing nicotinic acetylcholine receptor; Neuropharmacology; Vol. 77; 342-349; PMCID PMC3934363; 10.1016/j.neuropharm.2013.09.028
• Marotta, Christopher and Lester, Henry A., et el. (2014) Identifying Motifs Essential for Selective Activation of Nicotinic Acetylcholine Receptors; Biophysical Journal; Vol. 106; No. 2; 341A; 10.1016/j.bpj.2013.11.1951
• Post, Michael R. and Lester, Henry A., et el. (2014) Structure Function Studies at Two Different Nicotinic Acetylcholine Receptor Subtypes; Biophysical Journal; Vol. 106; No. 2; 341A; 10.1016/j.bpj.2013.11.1950
• Lester, Henry (2014) Drug Actions on Nicotinic Receptors. Chronic vs Acute; Outside-in vs Inside-out; Neuropsychopharmacology; Vol. 39; No. S1; 581-582
• Henderson, Brandon J. and Srinivasan, Rahul, et el. (2013) Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors; Journal of General Physiology; Vol. 143; No. 1; 51-66; PMCID PMC3874574; 10.1085/jgp.201311102
• Henley, Beverley M. and Williams, Brian A., et el. (2013) Transcriptional regulation by nicotine in dopaminergic neurons; Biochemical Pharmacology; Vol. 86; No. 8; 1074-1083; PMCID PMC3969234; 10.1016/j.bcp.2013.07.031
• Miles, Timothy F. and Dougherty, Dennis A., et el. (2013) The 5-HT_3AB Receptor Shows an A_3B_2 Stoichiometry at the Plasma Membrane; Biophysical Journal; Vol. 105; No. 4; 887-898; PMCID PMC3752109; 10.1016/j.bpj.2013.07.015
• Van Arnam, Ethan B. and Blythe, Emily E., et el. (2013) An Unusual Pattern of Ligand-Receptor Interactions for the α7 Nicotinic Acetylcholine Receptor, with Implications for the Binding of Varenicline; Molecular Pharmacology; Vol. 84; No. 2; 201-207; PMCID PMC3716316; 10.1124/mol.113.085795
• Frazier, Shawnalea J. and Cohen, Bruce N., et el. (2013) An Engineered Glutamate-gated Chloride (GluCl) Channel for Sensitive, Consistent Neuronal Silencing by Ivermectin; Journal of Biological Chemistry; Vol. 288; No. 29; 21029-21042; PMCID PMC3774370; 10.1074/jbc.M112.423921
• Chatterjee, Susmita and Santos, Nathan, et el. (2013) The α5 Subunit Regulates the Expression and Function of α4*-Containing Neuronal Nicotinic Acetylcholine Receptors in the Ventral-Tegmental Area; PLoS ONE; Vol. 8; No. 7; Art. No. e68300; PMCID PMC3712017; 10.1371/journal.pone.0068300
• Blum, Angela P. and Van Arnam, Ethan B., et el. (2013) Binding Interactions with the Complementary Subunit of Nicotinic Receptors; Journal of Biological Chemistry; Vol. 288; No. 10; 6991-6997; PMCID PMC3591609; 10.1074/jbc.M112.439968
• Limapichat, Walrati and Yu, Wesley Y., et el. (2013) Key Binding Interactions for Memantine in the NMDA Receptor; ACS Chemical Neuroscience; Vol. 4; No. 2; 255-260; PMCID PMC3751542; 10.1021/cn300180a
• O'Neill, Heidi C. and Laverty, Duncan C., et el. (2013) Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function; Pharmacology Biochemistry and Behavior; Vol. 103; No. 3; 603-621; PMCID PMC3544981; 10.1016/j.pbb.2012.10.014
• Lester, Henry A. and Miwa, Julie M., et el. (2012) Psychiatric Drugs Bind to Classical Targets Within Early Exocytotic Pathways: Therapeutic Effects; Biological Psychiatry; Vol. 72; No. 11; 907-915; PMCID PMC6167061; 10.1016/j.biopsych.2012.05.020
• Miles, Timothy F. and Bower, Kiowa S., et el. (2012) A Coupled Array of Noncovalent Interactions Impacts the Function of the 5‑HT_3A Serotonin Receptor in an Agonist-Specific Way; ACS Chemical Neuroscience; Vol. 3; No. 10; 753-760; PMCID PMC3474281; 10.1021/cn3000586
• Scott, Kimberly M. and Du, Jiangang, et el. (2012) Variability of acute extracellular action potential measurements with multisite silicon probes; Journal of Neuroscience Methods; Vol. 211; No. 1; 22-30; PMCID PMC3473102; 10.1016/j.jneumeth.2012.08.005
• Drenan, Ryan M. and Lester, Henry A. (2012) Insights into the Neurobiology of the Nicotinic Cholinergic System and Nicotine Addiction from Mice Expressing Nicotinic Receptors Harboring Gain-of-Function Mutations; Pharmacological Reviews; Vol. 64; No. 4; 869-879; PMCID PMC3462994; 10.1124/pr.111.004671
• Duffy, Noah H. and Lester, Henry A., et el. (2012) Ondansetron and Granisetron Binding Orientation in the 5‑HT_3 Receptor Determined by Unnatural Amino Acid Mutagenesis; ACS Chemical Biology; Vol. 7; No. 10; 1738-1745; PMCID PMC3477246; 10.1021/cb300246j
• Daeffler, Kristina N.-M. and Lester, Henry A., et el. (2012) Functionally Important Aromatic–Aromatic and Sulfur−π Interactions in the D2 Dopamine Receptor; Journal of the American Chemical Society; Vol. 134; No. 36; 14890-14896; PMCID PMC3461201; 10.1021/ja304560x
• Liu, Cambrian Y. and Xiao, Cheng, et el. (2012) Electrophysiological characterization of Grueneberg ganglion olfactory neurons: spontaneous firing, sodium conductance, and hyperpolarization-activated currents; Journal of Neurophysiology; Vol. 108; No. 5; 1318-1334; PMCID PMC3544954
• Shapiro, Mikhail G. and Frazier, Shawnalea J., et el. (2012) Unparalleled Control of Neural Activity Using Orthogonal Pharmacogenetics; ACS Chemical Neuroscience; Vol. 3; No. 8; 619-629; PMCID PMC3419455; 10.1021/cn300053q
• Miwa, Julie M. and Lester, Henry A., et el. (2012) Optimizing Cholinergic Tone Through Lynx Modulators of Nicotinic Receptors: Implications for Plasticity and Nicotine Addiction; Physiology; Vol. 27; No. 4; 187-199; 10.1152/physiol.00002.2012
• Srinivasan, Rahul and Richards, Christopher I., et el. (2012) Förster Resonance Energy Transfer (FRET) Correlates of Altered Subunit Stoichiometry in Cys-Loop Receptors, Exemplified by Nicotinic α4β2; International Journal of Molecular Sciences; Vol. 13; No. 8; 10022-10040; PMCID PMC3431844; 10.3390/ijms130810022
• Mackey, Elisha D. W. and Engle, Staci E., et el. (2012) α6* Nicotinic Acetylcholine Receptor Expression and Function in a Visual Salience Circuit; Journal of Neuroscience; Vol. 32; No. 30; 10226-10237; PMCID PMC3432940; 10.1523/JNEUROSCI.0007-12.2012
• Tavares, Ximena Da Silva and Blum, Angela P., et el. (2012) Variations in Binding Among Several Agonists at Two Stoichiometries of the Neuronal, α4β2 Nicotinic Receptor; Journal of the American Chemical Society; Vol. 134; No. 28; 11474-11480; PMCID PMC3399941; 10.1021/ja3011379
• Richards, Christopher I. and Luong, Khai, et el. (2012) Live-Cell Imaging of Single Receptor Composition Using Zero-Mode Waveguide Nanostructures; Nano Letters; Vol. 12; No. 7; 3690-3694; PMCID PMC3397148; 10.1021/nl301480h
• Puskar, Nyssa L. and Lester, Henry A., et el. (2012) Probing the Effects of Residues Located Outside the Agonist Binding Site on Drug-Receptor Selectivity in the Nicotinic Receptor; ACS Chemical Biology; Vol. 7; No. 5; 841-846; PMCID PMC3356501; 10.1021/cb200448j
• Srinivasan, Rahul and Richards, Christopher I., et el. (2012) Pharmacological Chaperoning of Nicotinic Acetylcholine Receptors Reduces the Endoplasmic Reticulum Stress Response; Molecular Pharmacology; Vol. 81; No. 6; 759-769; PMCID PMC3362896; 10.1124/mol.112.077792
• Murray, Teresa A. and Bertrand, Daniel, et el. (2012) α7β2 Nicotinic Acetylcholine Receptors Assemble, Function, and Are Activated Primarily via Their α7-α7 Interfaces; Molecular Pharmacology; Vol. 81; No. 2; 175-188; PMCID PMC3263954; 10.1124/mol.111.074088
• Cohen, B. N. and Mackey, E. D. W., et el. (2012) Nicotinic cholinergic mechanisms causing elevated dopamine release and abnormal locomotor behavior; Neuroscience; Vol. 200; 31-41; PMCID PMC3249511; 10.1016/j.neuroscience.2011.10.047
• Xiao, Cheng and Srinivasan, Rahul, et el. (2011) Characterizing functional α6β2 nicotinic acetylcholine receptors in vitro: Mutant β2 subunits improve membrane expression, and fluorescent proteins reveal responsive cells; Biochemical Pharmacology; Vol. 82; No. 8; 852-861; PMCID PMC3162078; 10.1016/j.bcp.2011.05.005
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• Lester, Henry A. (1991) Strategies for studying permeation at voltage-gated ion channels; Annual Review of Physiology; Vol. 53; 477-496
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• Lester, Henry A. (1988) Heterologous Expression of Excitability Proteins: Route to More Specific Drugs?; Science; Vol. 241; No. 4869; 1057-1063; 10.1126/science.2457947
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• Gurney, Alison M. and Lester, Henry A. (1987) Light-flash physiology with synthetic photosensitive compounds; Physiological Reviews; Vol. 67; No. 2; 583-617; 10.1152/physrev.1987.67.2.583
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• Chabala, Lee D. and Lester, Henry A. (1986) Activation of acetylcholine receptor channels by covalently bound agonists in cultured rat myoballs; Journal of Physiology; Vol. 379; No. 1; 83-108; PMCID PMC1182886; 10.1113/jphysiol.1986.sp016242
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• Krouse, Mauri E. and Lester, Henry A., et el. (1985) Rates and Equilibria for a Photoisomerizable Antagonist at the Acetylcholine Receptor of Electrophorus Electroplaques; Journal of General Physiology; Vol. 86; No. 2; 235-256; PMCID PMC2228782; 10.1085/jgp.86.2.235
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• Nerbonne, Jeanne M. and Sheridan, Robert E., et el. (1983) cis-3,3'-Bis-[α-(trimethylammonium)methyl]azobenzene (cis-Bis-Q). Purification and properties at acetylcholine receptors of Electrophorus electroplaques; Molecular pharmacology; Vol. 23; No. 2; 344-349
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• Sheridan, Robert E. and Lester, Henry A. (1982) Functional Stoichiometry at the Nicotinic Receptor. The Photon Cross Section for Phase 1 Corresponds to Two Bis-Q Molecules per Channel; Journal of General Physiology; Vol. 80; No. 4; 499-515; PMCID PMC2228709; 10.1085/jgp.80.4.499
• Lester, Henry A. and Nerbonne, Jeanne M. (1982) Physiological and Pharmacological Manipulations with Light Flashes; Annual Review of Biophysics and Bioengineering; Vol. 11; 151-175; 10.1146/annurev.bb.11.060182.001055
• Nargeot, Joel and Lester, Henry A., et el. (1982) A photoisomerizable muscarinic antagonist. Studies of binding and of conductance relaxations in frog heart; Journal of General Physiology; Vol. 79; No. 4; 657-678; PMCID PMC2215484; 10.1085/jgp.79.4.657
• Lester, Henry A. and Steer, Michael L., et el. (1982) ADP-Ribosylation of Membrane Proteins in Cholinergic Nerve Terminals; Journal of Neurochemistry; Vol. 38; No. 4; 1080-1086; 10.1111/j.1471-4159.1982.tb05351.x
• Lester, Henry A. and Steer, Michael L., et el. (1982) Prostaglandin-Stimulated GTP Hydrolysis Associated with Activation of Adenylate Cyclase in Human Platelet Membranes; Proceedings of the National Academy of Sciences of the United States of America; Vol. 79; No. 3; 719-723; PMCID PMC345823
• Steer, M. L. and Braun, S., et el. (1982) Activation of adenylate cyclase from purified platelet membranes by prostaglandin E1 and its inhibition by L-epinephrine: mechanistic effects; Journal of Cyclic Nucleotide Research; Vol. 8; No. 5; 309-322
• Lester, Henry A. (1981) A potpourri of plucked patches; Nature; Vol. 294; No. 5840; 398-399; 10.1038/294398a0
• Lester, Henry A. and Nass, Menasche M., et el. (1980) Electrophysiological Experiments With Photoisomerizable Cholinergic Compounds: Review and Progress Report; Annals of the New York Academy of Sciences; Vol. 346; 475-490; 10.1111/j.1749-6632.1980.tb22118.x
• Lester, Henry A. and Krouse, Mauri E., et el. (1980) A covalently bound photoisomerizable agonist. Comparison with reversibly bound agonists at electrophorus electroplaques; Journal of General Physiology; Vol. 75; No. 2; 207-232; PMCID PMC2215740; 10.1085/jgp.75.2.207
• Armstrong, David L. and Lester, Henry A. (1979) The kinetics of tubocurarine action and restricted diffusion within the synaptic cleft; Journal of Physiology; Vol. 294; No. 1; 365-386; PMCID PMC1280562; 10.1113/jphysiol.1979.sp012935
• Lester, Henry A. and Krouse, Mauri E., et el. (1979) Light-activated drug confirms a mechanism of ion channel blockade; Nature; Vol. 280; No. 5722; 509-510; 10.1038/280509a0
• Wathey, John C. and Nass, Menasche M., et el. (1979) Numerical reconstruction of the quantal event at nicotinic synapses; Biophysical Journal; Vol. 27; No. 1; 145-164; PMCID PMC1328553; 10.1016/s0006-3495(79)85208-x
• Koblin, Donald D. and Lester, Henry A. (1979) Voltage-dependent and voltage-independent blockade of acetylcholine receptors by local anesthetics in Electrophorus electroplaques; Molecular Pharmacology; Vol. 15; No. 3; 559-580
• Lester, Henry A. (1978) Analysis of sodium and potassium redistribution during sustained permeability increases at the innervated face of Electrophorus electroplaques; Journal of General Physiology; Vol. 72; No. 6; 857-862; PMCID PMC2228490; 10.1085/jgp.72.6.847
• Nass, Menasche M. and Lester, Henry A., et el. (1978) Response of acetylcholine receptors to photoisomerizations of bound agonist molecules; Biophysical Journal; Vol. 24; No. 1; 135-160; PMCID PMC1473870; 10.1016/s0006-3495(78)85352-1
• Lester, Henry A. and Koblin, Donald D., et el. (1978) Role of voltage-sensitive receptors in nicotinic transmission; Biophysical Journal; Vol. 21; No. 3; 181-194; PMCID PMC1473691; 10.1016/s0006-3495(78)85518-0
• Sheridan, Robert E. and Lester, Henry A. (1977) Rates and equilibria at the acetylcholine receptor of electrophorus electroplaques. A study of neurally evoked postsynaptic currents and of voltage-jump relaxations; Journal of General Physiology; Vol. 70; No. 2; 187-219; PMCID PMC2228462; 10.1085/jgp.70.2.187
• Lester, Henry A. and Chang, Hai Won (1977) Response of acetylcholine receptors to rapid photochemically produced increases in agonist concentration; Nature; Vol. 266; No. 5600; 373-374; 10.1038/266373a0
• Lester, Henry A. (1977) The response to acetylcholine; Scientific American; Vol. 236; No. 2; 106-118; 10.1038/scientificamerican0277-106
• Sheridan, Robert E. and Lester, Henry A. (1975) Relaxation measurements on the acetylcholine receptor; Proceedings of the National Academy of Sciences of the United States of America; Vol. 72; No. 9; 3496-3500; PMCID PMC433021; 10.1073/pnas.72.9.3496
• Lester, Henry A. and Changeux, Jean-Pierre, et el. (1975) Conductance increases produced by bath application of cholinergic agonists to Electrophorus electroplaques; Journal of General Physiology; Vol. 65; No. 6; 797-816; PMCID PMC2214893; 10.1085/jgp.65.6.797
• Lester, H. A. (1972) Vulnerability of desensitized or curare-treated acetylcholine receptors to irreversible blockade by cobra toxin; Molecular Pharmacology; Vol. 8; No. 6; 632-644
• Lester, H. A. (1972) Blockade of acetylcholine receptors by cobra toxin: electrophysiological studies; Molecular Pharmacology; Vol. 8; No. 6; 623-631
• Lester, Henry A. (1970) Postsynaptic Action of Cobra Toxin at the Myoneural Junction; Nature; Vol. 227; No. 5259; 727-728; 10.1038/227727a0
• Lester, Henry A. (1970) Transmitter Release by Presynaptic Impulses in the Squid Stellate Ganglion; Nature; Vol. 227; No. 5257; 493-496; 10.1038/227493a0