(orcid 0000-0001-5661-1714)
Griffin, Matthew E.; Sorum, Alexander W. et al. (2021) Sulfated glycans engage the Ang–Tie pathway to regulate vascular development Nature Chemical Biology; Vol. 17; No. 2; https://doi.org/10.1038/s41589-020-00657-7
Joffrin, Amélie M.; Hsieh-Wilson, Linda C. (2020) Photoaffinity Probes for the Identification of Sequence-Specific Glycosaminoglycan-Binding Proteins Journal of the American Chemical Society; Vol. 142; No. 32; https://doi.org/10.1021/jacs.0c06046
Pawar, Nitin J.; Wang, Lei et al. (2019) Expedient Synthesis of Core Disaccharide Building Blocks from Natural Polysaccharides for Heparan Sulfate Oligosaccharide Assembly Angewandte Chemie International Edition; Vol. 58; No. 51; https://doi.org/10.1002/anie.201908805
Liu, Liang-Chih; Wang, Yuan-Liang et al. (2019) Long non-coding RNA HOTAIR promotes invasion of breast cancer cells through chondroitin sulfotransferase CHST15 International Journal of Cancer; Vol. 145; No. 9; https://doi.org/10.1002/ijc.32319
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Hsieh-Wilson, Linda C. (2018) A Molecular Window into the Brain: Special Issue on Molecules and the Brain Biochemistry; Vol. 57; No. 27; https://doi.org/10.1021/acs.biochem.8b00689
Thompson, John W.; Sorum, Alexander W. et al. (2018) Deciphering the functions of O-GlcNAc glycosylation in the brain: The role of site-specific quantitative O-GlcNAcomics Biochemistry; Vol. 57; No. 27; https://doi.org/10.1021/acs.biochem.8b00516
Stopschinski, Barbara E.; Holmes, Brandon B. et al. (2018) Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus α-synuclein and β-amyloid aggregates Journal of Biological Chemistry; Vol. 293; No. 27; https://resolver.caltech.edu/CaltechAUTHORS:20180712-075603717
Rauch, Jennifer N.; Chen, John J. et al. (2018) Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs) Scientific Reports; Vol. 8; https://resolver.caltech.edu/CaltechAUTHORS:20180430-133533074
Matho, Michael H.; Schlossman, Andrew et al. (2018) Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8 Journal of Biological Chemistry; Vol. 293; No. 1; https://doi.org/10.1074/jbc.M117.814541
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Griffith, Adam R.; Rogers, Claude J. et al. (2017) Predicting glycosaminoglycan surface protein interactions and implications for studying axonal growth Proceedings of the National Academy of Sciences of the United States of America; Vol. 114; No. 52; https://doi.org/10.1073/pnas.1715093115
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Wang, Andrew C.; Jensen, Elizabeth H. et al. (2016) Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration Proceedings of the National Academy of Sciences of the United States of America; Vol. 113; No. 52; https://doi.org/10.1073/pnas.1606899113
Griffin, Matthew E.; Jensen, Elizabeth H. et al. (2016) Comprehensive mapping of O-GlcNAc modification sites using a chemically cleavable tag Molecular BioSystems; Vol. 12; No. 6; https://doi.org/10.1039/C6MB00138F
Griffin, Matthew E.; Hsieh-Wilson, Linda C. (2016) Glycan Engineering for Cell and Developmental Biology Cell Chemical Biology; Vol. 23; No. 1; https://doi.org/10.1016/j.chembiol.2015.12.007
Miller, Gregory M.; Hsieh-Wilson, Linda C. (2015) Sugar-Dependent Modulation of Neuronal Development, Regeneration, and Plasticity by Chondroitin Sulfate Proteoglycans Experimental Neurology; Vol. 274; No. B; https://doi.org/10.1016/j.expneurol.2015.08.015
Hsieh-Wilson, Linda C. (2015) Carbohydrate signaling in the brain Abstracts of Papers of the American Chemical Society; Vol. 249; In: 249th American Chemical Society National Meeting & Exposition, March 22-26, 2015, Denver, CO https://resolver.caltech.edu/CaltechAUTHORS:20150422-142707710
Pulsipher, Abigail; Griffin, Matthew E. et al. (2015) Long-Lived Engineering of Glycans to Direct Stem Cell Fate Angewandte Chemie International Edition; Vol. 54; No. 5; https://doi.org/10.1002/anie.201409258
Matho, Michael H.; de Val, Natalia et al. (2014) Murine Anti-vaccinia Virus D8 Antibodies Target Different Epitopes and Differ in Their Ability to Block D8 Binding to CS-E PLoS Pathogens; Vol. 10; No. 12; https://doi.org/10.1371/journal.ppat.1004495
Wibowo, Arif; Peters, Eric C. et al. (2014) Photoactivatable Glycopolymers for the Proteome-Wide Identification of Fucose-α(1-2)-Galactose Binding Proteins Journal of the American Chemical Society; Vol. 136; No. 27; https://doi.org/10.1021/ja502482a
Pulsipher, Abigail; Griffin, Matthew E. et al. (2014) Directing Neuronal Signaling through Cell-Surface Glycan Engineering Journal of the American Chemical Society; Vol. 136; No. 19; https://doi.org/10.1021/ja5005174
Hsieh-Wilson, Linda C.; Griffin, Matthew E. (2013) Improving Biologic Drugs via Total Chemical Synthesis Science; Vol. 342; No. 6164; https://doi.org/10.1126/science.1247615
Griffin, Matthew E.; Hsieh-Wilson, Linda C. (2013) Synthetic probes of glycosaminoglycan function Current Opinion in Chemical Biology; Vol. 17; No. 6; https://doi.org/10.1016/j.cbpa.2013.09.015
Clark, Peter M.; Rexach, Jessica E. et al. (2013) Visualization of O-GlcNAc Glycosylation Stoichiometry and Dynamics Using Resolvable Poly(ethylene glycol) Mass Tags Current Protocols in Chemical Biology; Vol. 5; https://doi.org/10.1002/9780470559277.ch130153
Oh, Young In; Sheng, Gloria J. et al. (2013) Tailored Glycopolymers as Anticoagulant Heparin Mimetics Angewandte Chemie International Edition; Vol. 52; No. 45; https://doi.org/10.1002/anie.201306968
Dick, Gunnar; Tan, Chin Lik et al. (2013) Semaphorin 3A Binds to the Perineuronal Nets via Chondroitin Sulfate Type E Motifs in Rodent Brains Journal of Biological Chemistry; Vol. 288; No. 38; https://doi.org/10.1074/jbc.M111.310029
Ramakrishnan, Parameswaran; Clark, Peter M. et al. (2013) Activation of the Transcriptional Function of the NF-κB Protein c-Rel by O-GlcNAc Glycosylation Science Signaling; Vol. 6; No. 290; https://doi.org/10.1126/scisignal.2004097
Sheng, Gloria J.; Oh, Young In et al. (2013) Tunable Heparan Sulfate Mimetics for Modulating Chemokine Activity Journal of the American Chemical Society; Vol. 135; No. 30; https://doi.org/10.1021/ja4027727
Hsieh-Wilson, Linda C. (2013) O-GlcNAc Signaling Regulates Cancer Metabolism FASEB Journal; Vol. 27; In: Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB), April 20-24, 2013, Boston, MA https://resolver.caltech.edu/CaltechAUTHORS:20130711-095912038
Yi, Wen; Clark, Peter M. et al. (2012) Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism Science; Vol. 337; No. 6097; https://doi.org/10.1126/science.1222278
Brown, Joshua M.; Xia, Jiang et al. (2012) A sulfated carbohydrate epitope inhibits axon regeneration after injury Proceedings of the National Academy of Sciences of the United States of America; Vol. 109; No. 13; https://doi.org/10.1073/pnas.1121318109
Chaubard, Jean-Luc; Krishnamurthy, Chithra et al. (2012) Chemoenzymatic Probes for Detecting and Imaging Fucose-α(1-2)-galactose Glycan Biomarkers Journal of the American Chemical Society; Vol. 134; No. 10; https://doi.org/10.1021/ja211312u
Rexach, Jessica E.; Clark, Peter M. et al. (2012) Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation Nature Chemical Biology; Vol. 8; No. 3; https://doi.org/10.1038/NCHEMBIO.770
Rogers, Claude J.; Clark, Peter M. et al. (2011) Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches Proceedings of the National Academy of Sciences of the United States of America; Vol. 108; No. 24; https://doi.org/10.1073/pnas.1102962108
Lee, Song-Gil; Brown, Joshua M. et al. (2010) End-functionalized glycopolymers as mimetics of chondroitin sulfate proteoglycans Chemical Science; Vol. 1; No. 3; https://doi.org/10.1039/c0sc00271b
Rexach, Jessica E.; Rogers, Claude J. et al. (2010) Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags Nature Chemical Biology; Vol. 6; No. 9; https://doi.org/10.1038/NCHEMBIO.412
Murrey, Heather E.; Ficarro, Scott B. et al. (2009) Identification of the Plasticity-Relevant Fucose-α(1−2)-Galactose Proteome from the Mouse Olfactory Bulb Biochemistry; Vol. 48; No. 30; https://doi.org/10.1021/bi900640x
Wang, Zihao; Park, Kyoungsook et al. (2009) Site-Specific GlcNAcylation of Human Erythrocyte Proteins Potential Biomarker(s) for Diabetes Diabetes; Vol. 58; No. 2; https://doi.org/10.2337/db08-0994
Clark, Peter M.; Dweck, Jessica F. et al. (2008) Direct in-gel fluorescence detection and cellular imaging of O-GlcNAc-modified proteins Journal of the American Chemical Society; Vol. 130; No. 35; https://doi.org/10.1021/ja8030467
Murrey, Heather E.; Hsieh-Wilson, Linda C. (2008) The Chemical Neurobiology of Carbohydrates Chemical Reviews; Vol. 108; No. 5; https://doi.org/10.1021/cr078215f
Rawat, Manish; Gama, Cristal I. et al. (2008) Neuroactive chondroitin sulfate glycomimetics Journal of the American Chemical Society; Vol. 130; No. 10; https://doi.org/10.1021/ja709993p
Rexach, Jessica E.; Clark, Peter M. et al. (2008) Chemical approaches to understanding O-GlcNAc glycosylation in the brain Nature Chemical Biology; Vol. 4; No. 2; https://doi.org/10.1038/nchembio.68
Sotogaku, Naoki; Tully, Sarah E. et al. (2007) Activation of phospholipase C pathways by a synthetic chondroitin sulfate-E tetrasaccharide promotes neurite outgrowth of dopaminergic neurons Journal of Neurochemistry; Vol. 103; No. 2; https://doi.org/10.1111/j.1471-4159.2007.04849.x
Khidekel, Nelly; Ficarro, Scott B. et al. (2007) Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics Nature Chemical Biology; Vol. 3; No. 6; https://doi.org/10.1038/nchembio881
Boeggeman, Elizabeth; Ramakrishnan, Boopathy et al. (2007) Direct identification of nonreducing GlcNAc residues on N-glycans of glycoproteins using a novel chemoenzymatic method Bioconjugate Chemistry; Vol. 18; No. 3; https://doi.org/10.1021/bc060341n
Shipp, Eric L.; Hsieh-Wilson, Linda C. (2007) Profiling the sulfation specificities of glycosaminoglycan interactions with growth factors and chemotactic proteins using microarrays Chemistry and Biology; Vol. 14; No. 2; https://doi.org/10.1016/j.chembiol.2006.12.009
Hsieh-Wilson, Linda C. (2007) Bioorganic Chemistry: A Sweet Synthesis Nature; Vol. 445; No. 7123; https://doi.org/10.1038/445031a
Gama, Cristal I.; Tully, Sarah E. et al. (2006) Sulfation patterns of glycosaminoglycans encode molecular recognition and activity Nature Chemical Biology; Vol. 2; No. 9; https://doi.org/10.1038/nchembio810
Tully, Sarah E.; Rawat, Manish et al. (2006) Discovery of a TNF-α Antagonist Using Chondroitin Sulfate Microarrays Journal of the American Chemical Society; Vol. 128; No. 24; https://doi.org/10.1021/ja061906t
Murrey, Heather E.; Gama, Cristal I. et al. (2006) Protein fucosylation regulates synapsin Ia/Ib expression and neuronal morphology in primary hippocampal neurons Proceedings of the National Academy of Sciences of the United States of America; Vol. 103; No. 1; https://doi.org/10.1073/pnas.0503381102
Gama, Cristal I.; Hsieh-Wilson, Linda C. (2005) Chemical approaches to deciphering the glycosaminoglycan code Current Opinion in Chemical Biology; Vol. 9; No. 6; https://doi.org/10.1016/j.cbpa.2005.10.003
Uematsu, Ken; Futter, Marie et al. (2005) Regulation of spinophilin Ser94 phosphorylation in neostriatal neurons involves both DARPP-32-dependent and independent pathways Journal of Neurochemistry; Vol. 95; No. 6; https://doi.org/10.1111/j.1471-4159.2005.03491.x
Kalovidouris, Stacey A.; Gama, Cristal I. et al. (2005) A Role for Fucose α(1−2) Galactose Carbohydrates in Neuronal Growth Journal of the American Chemical Society; Vol. 127; No. 5; https://doi.org/10.1021/ja044631v
Hsieh-Wilson, Linda C. (2004) Tailor-made glycoproteins Trends in Biotechnology; Vol. 22; No. 10; https://doi.org/10.1016/j.tibtech.2004.08.009
Khidekel, Nelly; Ficarro, Scott B. et al. (2004) Exploring the O-GlcNAc proteome: Direct identification of O-GlcNAc-modified proteins from the brain Proceedings of the National Academy of Sciences of the United States of America; Vol. 101; No. 36; https://doi.org/10.1073/pnas.0403471101
Tai, Hwan-Ching; Khidekel, Nelly et al. (2004) Parallel identification of O-GlcNAc-modified proteins from cell lysates Journal of the American Chemical Society; Vol. 126; No. 34; https://doi.org/10.1021/ja047872b
Grossman, Stacie D.; Futter, Marie et al. (2004) Spinophilin is phosphorylated by Ca^(2+)/calmodulin-dependent protein kinase II resulting in regulation of its binding to F-actin Journal of Neurochemistry; Vol. 90; No. 2; https://doi.org/10.1111/j.1471-4159.2004.02491.x
Tully, Sarah E.; Mabon, Ross et al. (2004) A chondroitin sulfate small molecule that stimulates neuronal growth Journal of the American Chemical Society; Vol. 126; No. 25; https://doi.org/10.1021/ja0484045
Khidekel, Nelly; Hsieh-Wilson, Linda C. (2004) A 'molecular switchboard' - covalent modifications to proteins and their impact on transcription Organic and Biomolecular Chemistry; Vol. 2; No. 1; https://doi.org/10.1039/b312466e
Khidekel, Nelly; Arndt, Sabine et al. (2003) A Chemoenzymatic Approach toward the Rapid and Sensitive Detection of O-GlcNAc Posttranslational Modifications Journal of the American Chemical Society; Vol. 125; No. 52; https://doi.org/10.1021/ja038545r
Arndt, Sabine; Hsieh-Wilson, Linda C. (2003) Use of Cerny epoxides for the accelerated synthesis of glycosaminoglycans Organic Letters; Vol. 5; No. 22; https://doi.org/10.1021/ol035606h
Lamarre-Vincent, Nathan; Hsieh-Wilson, Linda C. (2003) Dynamic glycosylation of the transcription factor CREB: A potential role in gene regulation Journal of the American Chemical Society; Vol. 125; No. 22; https://doi.org/10.1021/ja028200t
Hsieh-Wilson, Linda C.; Benfenati, Fabio et al. (2003) Phosphorylation of Spinophilin Modulates Its Interaction with Actin Filaments Journal of Biological Chemistry; Vol. 278; No. 2; https://doi.org/10.1074/jbc.M205754200
Grossman, Stacie D.; Hsieh-Wilson, Linda C. et al. (2002) The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines NeuroMolecular Medicine; Vol. 2; No. 1; https://doi.org/10.1385/NMM:2:1:61
Watanabe, Takuo; Huang, Hsien-Bin et al. (2001) Protein phosphatase 1 regulation by inhibitors and targeting subunits Proceedings of the National Academy of Sciences of the United States of America; Vol. 98; No. 6; https://doi.org/10.1073/pnas.051003898
Allen, P. B.; Hsieh-Wilson, Linda C. et al. (1999) Control of protein phosphatase I in the dendrite Biochemical Society Transactions; Vol. 27; No. 4; In: Colloquium on Membrane Signalling Complexes, 7-9 April 1999, Glasgow, Scotland https://doi.org/10.1042/bst0270543
Hsieh-Wilson, Linda C.; Allen, Patrick B. et al. (1999) Characterization of the Neuronal Targeting Protein Spinophilin and Its Interactions with Protein Phosphatase-1 Biochemistry; Vol. 38; No. 14; https://doi.org/10.1021/bi982900m
Yan, Zhen; Hsieh-Wilson, Linda et al. (1999) Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP−32 and spinophilin Nature Neuroscience; Vol. 2; No. 1; https://doi.org/10.1038/4516
Ma, Lifu; Hsieh-Wilson, Linda C. et al. (1998) Antibody catalysis of peptidyl-prolyl cis-trans isomerization in the folding of RNase T1 Proceedings of the National Academy of Sciences of the United States of America; Vol. 95; No. 13; https://resolver.caltech.edu/CaltechAUTHORS:MALpnas98
Hsieh-Wilson, Linda C.; Schultz, Peter G. et al. (1996) Insights into antibody catalysis: Structure of an oxygenation catalyst at 1.9-Å resolution Proceedings of the National Academy of Sciences of the United States of America; Vol. 93; No. 11; https://resolver.caltech.edu/CaltechAUTHORS:HSIpnas96
Hsieh-Wilson, Linda C.; Xiang, Xiao-Dong et al. (1996) Lessons from the immune system: From catalysis to materials science Accounts of Chemical Research; Vol. 29; No. 3; https://doi.org/10.1021/ar950247e
Stevens, Raymond C.; Hsieh-Wilson, Linda C. et al. (1996) Structural Studies of Catalytic Antibodies Israel Journal of Chemistry; Vol. 36; No. 2; https://doi.org/10.1002/ijch.199600018
Hsieh-Wilson, Linda C.; Stephans, James C. et al. (1994) An Efficient Antibody-Catalyzed Oxygenation Reaction Journal of the American Chemical Society; Vol. 116; No. 5; https://doi.org/10.1021/ja00084a076
Yu, Jaehoon; Hsieh-Wilson, Linda C. et al. (1994) Progress toward an Antibody Glycosidase Angewandte Chemie-International Edition In English; Vol. 33; No. 3; https://doi.org/10.1002/anie.199403391
Hsieh-Wilson, Linda C.; Yonkovich, Shirlee et al. (1993) Controlling Chemical Reactivity with Antibodies Science; Vol. 260; No. 5106; https://doi.org/10.1126/science.10049109