- Mamrosh, Jennifer L.; Sherman, David J.; et el. (2023) Quantitative
measurement of the requirement of diverse protein degradation pathways
in MHC class I peptide presentation; Science Advances; Vol. 9;
No. 25; eade7890; PMCID PMC10289651; 10.1126/sciadv.ade7890
- Zhang, Yaru; Jost, Marco; et el. (2022) Adaptive
exchange sustains cullin–RING ubiquitin ligase networks and proper
licensing of DNA replication; Proceedings of the National Academy of
Sciences of the United States of America; Vol. 119; No. 36; Art.
No. e2205608119; PMCID PMC9456757; 10.1073/pnas.2205608119
- Mamrosh, Jennifer L.; Sherman, David J.; et el. (2021) A
Systematic Interrogation of MHC Class I Peptide Presentation Identifies
Constitutive and Compensatory Protein Degradation Pathways; 10.1101/2021.10.07.463289
- Porras-Yakushi, Tanya R.; Reitsma, Justin M.; et el. (2021) In
depth proteomic analysis of proteasome inhibitors bortezomib,
carfilzomib and MG132 reveals that mortality factor 4-like 1 (MORF4L1)
protein ubiquitylation is negatively impacted; Journal of
Proteomics; Vol. 241; Art. No. 104197; 10.1016/j.jprot.2021.104197
- Zhang, Gang; Li, Shan; et el. (2021) A
covalent p97/VCP ATPase inhibitor can overcome resistance to CB-5083 and
NMS-873 in colorectal cancer cells; European Journal of Medicinal
Chemistry; Vol. 213; Art. No. 113148; PMCID PMC7954469; 10.1016/j.ejmech.2020.113148
- Arango-Gonzalez, Blanca; Sen, Merve; et el. (2020) Inhibition
of VCP preserves retinal structure and function in autosomal dominant
retinal degeneration; 10.1101/2020.11.17.384669
- Yang, Seung-Joo; Jeon, Seung-Je; et el. (2020) Ubiquitin-dependent
proteasomal degradation of AMPK gamma subunit by Cereblon inhibits AMPK
activity; Biochimica et Biophysica Acta; Vol. 1867; No. 8; Art.
No. 118729; 10.1016/j.bbamcr.2020.118729
- Reichermeier, Kurt M.; Straube, Ronny; et el. (2020) PIKES
Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of
the CRL4 Network; Molecular Cell; Vol. 77; No. 5; 1092-1106; 10.1016/j.molcel.2019.12.013
- Blythe, Emily E.; Gates, Stephanie N.; et el. (2019) Multisystem
Proteinopathy Mutations in VCP/p97 Increase NPLOC4·UFD1L Binding and
Substrate Processing; Structure; Vol. 27; No. 12; 1820-1829; PMCID
PMC6929323; 10.1016/j.str.2019.09.011
- Yu, Helen H.; Reitsma, Justin M.; et el. (2019) Single
subunit degradation of WIZ, a lenalidomide- and pomalidomide dependent
substrate of E3 ubiquitin ligase CRL4^(CRBN); 10.1101/595389
- Li, Jing; Zhang, Yaru; et el. (2018) Epidithiodiketopiperazines
Inhibit Protein Degradation by Targeting Proteasome Deubiquitinase
Rpn11; Cell Chemical Biology; Vol. 25; No. 11; 1350-1358; PMCID
PMC6309308; 10.1016/j.chembiol.2018.07.012
- Verma, Rati; Reichermeier, Kurt M.; et el. (2018) Vms1
and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled
ribosomes; Nature; Vol. 557; No. 7705; 446-451; PMCID PMC6226276; 10.1038/s41586-018-0022-5
- Lobanova, Ekaterina S.; Finkelstein, Stella; et el. (2018) Increased
proteasomal activity supports photoreceptor survival in inherited
retinal degeneration; Nature Communications; Vol. 9; Art. No. 1738;
PMCID PMC5928105; 10.1038/s41467-018-04117-8
- Liu, Xing; Reitsma, Justin M.; et el. (2018) Cand1-Mediated
Adaptive Exchange Mechanism Enables Variation in F-Box Protein
Expression; Molecular Cell; Vol. 69; No. 5; 773-786; PMCID
PMC5836512; 10.1016/j.molcel.2018.01.038
- Blythe, E. E.; Martin, A.; et el. (2017) Characterization
of p97 mutations causing multisystem proteinopathy support a
gain-of-function model for pathology; Molecular Biology of the Cell;
Vol. 28; No. 26; Art. No. M125; 10.1091/mbc.E17-10-0618
- Skrott, Zdenek; Li, Jing; et el. (2017) Alcohol-abuse
drug disulfiram targets cancer via p97 segregase adaptor NPL4;
Nature; Vol. 552; No. 7684; 194-199; PMCID PMC5730499; 10.1038/nature25016
- Nakasone, Mark A.; Lewis, Timothy A.; et el. (2017) Structural
Basis for the Inhibitory Effects of Ubistatins in the
Ubiquitin-Proteasome Pathway; Structure; Vol. 25; No. 12; 1839-1855;
10.1016/j.str.2017.10.007
- Reitsma, Justin M.; Liu, Xing; et el. (2017) Composition
and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases;
Cell; Vol. 171; No. 6; 1326-1339; PMCID PMC5711595; 10.1016/j.cell.2017.10.016
- Lauinger, Linda; Li, Jing; et el. (2017) Thiolutin
is a zinc chelator that inhibits the Rpn11 and other JAMM
metalloproteases; Nature Chemical Biology; Vol. 13; No. 7; 709-714;
10.1038/nchembio.2370
- Blythe, Emily E.; Olson, Kristine C.; et el. (2017) Ubiquitin-
and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced
by a mutation that causes multisystem proteinopathy; Proceedings of
the National Academy of Sciences of the United States of America; Vol.
114; No. 22; E4380-E4388; PMCID PMC5465906; 10.1073/pnas.1706205114
- Li, Jing; Yakushi, Tanya; et el. (2017) Capzimin
is a potent and specific inhibitor of proteasome isopeptidase Rpn11;
Nature Chemical Biology; Vol. 13; No. 5; 486-493; PMCID PMC5570473; 10.1038/nchembio.2326
- Nguyen, Van Thang; Li, Jing; et el. (2017) p97/VCP
promotes degradation of CRBN substrate glutamine synthetase and
neosubstrates; Proceedings of the National Academy of Sciences of
the United States of America; Vol. 114; No. 14; 3565-3571; PMCID
PMC5389304; 10.1073/pnas.1700949114
- Reiterer, Veronika; Figueras-Puig, Cristina; et el. (2017) The
pseudophosphatase STYX targets the F‐box of FBXW7 and inhibits
SCF^(FBXW7) function; EMBO Journal; Vol. 36; No. 3; 260-273; PMCID
PMC5286380; 10.15252/embj.201694795
- Vangala, Janakiram R.; Sotzny, Franziska; et el. (2016) Nrf1
can be processed and activated in a proteasome-independent manner;
Current Biology; Vol. 26; No. 18; R834-R835; PMCID PMC6156719; 10.1016/j.cub.2016.08.008
- Sung, Min-Kyung; Reitsma, Justin M.; et el. (2016) Ribosomal
proteins produced in excess are degraded by the ubiquitin-proteasome
system; Molecular Biology of the Cell; Vol. 27; No. 17; 2642-2652;
PMCID PMC5007085; 10.1091/mbc.E16-05-0290
- Xue, Liang; Blythe, Emily E.; et el. (2016) Valosin-containing
protein (VCP)–Adaptor Interactions are Exceptionally Dynamic and Subject
to Differential Modulation by a VCP Inhibitor; Molecular and
Cellular Proteomics; Vol. 15; No. 9; 2970-2986; PMCID PMC5013311; 10.1074/mcp.M116.061036
- Kleiger, Gary and Deshaies, Raymond (2016) Tag
Team Ubiquitin Ligases; Cell; Vol. 166; No. 5; 1080-1081; 10.1016/j.cell.2016.08.014
- Sung, Min-Kyung; Porras-Yakushi, Tanya R.; et el. (2016) A
conserved quality-control pathway that mediates degradation of
unassembled ribosomal proteins; eLife; Vol. 5; Art. No. e19105;
PMCID PMC5026473; 10.7554/eLife.19105
- Mosadeghi, Ruzbeh; Reichermeier, Kurt M.; et el. (2016) Structural
and kinetic analysis of the COP9-Signalosome activation and the
cullin-RING ubiquitin ligase deneddylation cycle; eLife; Vol. 5;
Art. No. e12102; PMCID PMC4878873; 10.7554/eLife.12102
- Nguyen, Thang Van; Lee, J. Eugene; et el. (2016) Glutamine
Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via
the Thalidomide Receptor Cereblon; Molecular Cell; Vol. 61; No. 6;
809-820; PMCID PMC4889030; 10.1016/j.molcel.2016.02.032
- Banerjee, Sooiay; Bartesaghi, Alberto; et el. (2016) 2.3
Å resolution cryo-EM structure of human p97 and mechanism of allosteric
inhibition; Science; Vol. 351; No. 6275; 871-875; 10.1126/science.aad7974
- Alverez, Celeste; Bulfer, Stacie L.; et el. (2016) Allosteric
Indole Amide Inhibitors of p97: Identification of a Novel Probe of the
Ubiquitin Pathway; ACS Medicinal Chemistry Letters; Vol. 7; No. 2;
182-187; 10.1021/acsmedchemlett.5b00396
- Deshaies, Raymond J. (2015) Protein
degradation: Prime time for PROTACs; Nature Chemical Biology; Vol.
11; No. 9; 634-635; 10.1038/nchembio.1887
- Deshaies, Raymond and Li, Jing (2015) Exploiting
protein homeostasis for cancer therapy
- Pulvino, Mary; Chen, Luojing; et el. (2015) Inhibition
of COP9-signalosome (CSN) deneddylating activity and tumor growth of
diffuse large B-cell lymphomas by doxycycline; Oncotarget; Vol. 6;
No. 17; 14796-14813; PMCID PMC4558116; 10.18632/oncotarget.4193
- Fang, Nancy N.; Chan, Gerard T.; et el. (2014) Rsp5/Nedd4
is the main ubiquitin ligase that targets cytosolic misfolded proteins
following heat stress; Nature Cell Biology; Vol. 16; No. 12;
1227-1237; PMCID PMC5224936; 10.1038/ncb3054
- Deshaies, Raymond J. (2014) Proteotoxic
crisis, the ubiquitin-proteasome system, and cancer therapy; BMC
Biology; Vol. 12; Art. No. 94; PMCID PMC4226866; 10.1186/s12915-014-0094-0
- Deshaies, Raymond J. (2014) Corralling
a protein-degradation regulator; Nature; Vol. 512; No. 7513;
145-146; 10.1038/nature13644
- Chou, Tsui-Fen; Bulfer, Stacie L.; et el. (2014) Specific
Inhibition of p97/VCP ATPase and Kinetic Analysis Demonstrate
Interaction between D1 and D2 ATPase domains; Journal of Molecular
Biology; Vol. 426; No. 15; 2886-2899; PMCID PMC4102644; 10.1016/j.jmb.2014.05.022
- Deshaies, Raymond J. (2014) Structural
biology: Corralling a protein-degradation regulator; Nature; 10.1038/nature13644
- Chan, Nickie C.; den Besten, Willem; et el. (2014) Degradation
of the Deubiquitinating Enzyme USP33 is Mediated by p97 and the
Ubiquitin Ligase HERC2; Journal of Biological Chemistry; Vol. 289;
No. 28; 19789-19798; PMCID PMC4094088; 10.1074/jbc.M114.569392
- Deshaies, Raymond; Chou, Tsui-Fen; et el. (2014) Exploiting
protein homeostasis for cancer therapy; FASEB Journal; Vol. 28;
No. 1; 472.2
- Honarpour, Narimon; Rose, Christopher M.; et el. (2014) F-box
Protein FBXL16 Binds PP2A-B55α and Regulates Differentiation of
Embryonic Stem Cells along the FLK1+ Lineage; Molecular and Cellular
Proteomics; Vol. 13; No. 3; 780-791; PMCID PMC3945908; 10.1074/mcp.M113.031765
- Radhakrishnan, Senthil K.; den Besten, Willem; et el. (2014) p97-dependent
retrotranslocation and proteolytic processing govern formation of active
Nrf1 upon proteasome inhibition; eLife; Vol. 3; Art. No. e01856;
PMCID PMC3896944; 10.7554/elife.01856
- Kolawa, Natalie; Sweredoski, Michael J.; et el. (2013) Perturbations
to the Ubiquitin Conjugate Proteome in Yeast Δubx Mutants Identify Ubx2
as a Regulator of Membrane Lipid Composition; Molecular and Cellular
Proteomics; Vol. 12; No. 10; 2791-2803; PMCID PMC3790291; 10.1074/mcp.M113.030163
- Kurimchak, Alison; Haines, Dale S.; et el. (2013) Activation
of p107 by Fibroblast Growth Factor, Which Is Essential for Chondrocyte
Cell Cycle Exit, Is Mediated by the Protein Phosphatase 2A/B55α
Holoenzyme; Molecular and Cellular Biology; Vol. 33; No. 16;
3330-3342; PMCID PMC3753905; 10.1128/MCB.00082-13
- Shi, Yihui; Liu, Xiaohe; et el. (2013) Development
of functional assays for p97/VCP inhibition; Cancer Research; Vol.
73; No. 8; Art. No. 2146; 10.1158/1538-7445.AM2013-2146
- Pierce, Nathan W.; Lee, J. Eugene; et el. (2013) Cand1
Promotes Assembly of New SCF Complexes through Dynamic Exchange of F Box
Proteins; Cell; Vol. 153; No. 1; 206-215; PMCID PMC3656483; 10.1016/j.cell.2013.02.024
- Chou, Tsui-Fen; Li, Kelin; et el. (2013) Structure–Activity
Relationship Study Reveals ML240 and ML241 as Potent and Selective
Inhibitors of p97 ATPase; ChemMedChem; Vol. 8; No. 2; 297-312; PMCID
PMC3662613; 10.1002/cmdc.201200520
- Verma, Rati; Oania, Robert S.; et el. (2013) Cdc48/p97
promotes degradation of aberrant nascent polypeptides bound to the
ribosome; eLife; Vol. 2013; No. 2; Art. No. e00308; PMCID
PMC3552423; 10.7554/eLife.00308
- Emberley, Ethan D.; Mosadeghi, Ruzbeh; et el. (2012) Deconjugation
of Nedd8 from Cul1 Is Directly Regulated by Skp1-F-box and Substrate,
and the COP9 Signalosome Inhibits Deneddylated SCF by a Noncatalytic
Mechanism; Journal of Biological Chemistry; Vol. 287; No. 35;
29679-29689; PMCID PMC3436198; 10.1074/jbc.M112.352484
- Oh, Younghoon; Chang, Kuang-Jung; et el. (2012) Mitotic
exit kinase Dbf2 directly phosphorylates chitin synthase Chs2 to
regulate cytokinesis in budding yeast; Molecular Biology of the
Cell; Vol. 23; No. 13; 2445-2456; PMCID PMC3386209; 10.1091/mbc.E12-01-0033
- Haines, Dale S.; Lee, J. Eugene; et el. (2012) Protein
Interaction Profiling of the p97 Adaptor UBXD1 Points to a Role for the
Complex in Modulating ERGIC-53 Trafficking; Molecular and Cellular
Proteomics; Vol. 11; No. 6; Art. No. M111.016444; PMCID PMC3433925; 10.1074/mcp.M111.016444
- den Besten, Willem; Verma, Rati; et el. (2012) NEDD8
links cullin-RING ubiquitin ligase function to the p97 pathway;
Nature Structural & Molecular Biology; Vol. 19; No. 5; 511-516;
PMCID PMC3348432; 10.1038/nsmb.2269
- Sohn, Chang Ho; Agnew, Heather D.; et el. (2012) Designer
Reagents for Mass Spectrometry-Based Proteomics: Clickable Cross-Linkers
for Elucidation of Protein Structures and Interactions; Analytical
Chemistry; Vol. 84; No. 6; 2662-2669; PMCID PMC3310289; 10.1021/ac202637n
- Sohn, Chang Ho; Lee, J. Eugene; et el. (2012) Click
Chemistry Facilitates Formation of Reporter Ions and Simplified
Synthesis of Amine-Reactive Multiplexed Isobaric Tags for Protein
Quantification; Journal of the American Chemical Society; Vol. 134;
No. 5; 2672-2680; PMCID PMC3668889; 10.1021/ja2099003
- Chou, Tsui-Fen and Deshaies, Raymond J. (2011) Development
of p97 AAA ATPase inhibitors; Autophagy; Vol. 7; No. 9; 1091-1092;
PMCID PMC3210319; 10.4161/auto.7.9.16489
- Rabut, Gwenaël; Le Dez, Gaëlle; et el. (2011) The
TFIIH Subunit Tfb3 Regulates Cullin Neddylation; Molecular Cell;
Vol. 43; No. 3; 488-495; PMCID PMC3186349; 10.1016/j.molcel.2011.05.032
- Gomez, Tara A.; Kolawa, Natalie; et el. (2011) Identification
of a functional docking site in the Rpn1 LRR domain for the UBA-UBL
domain protein Ddi1; BMC Biology; Vol. 9; Art. No. 33; PMCID
PMC3126750; 10.1186/1741-7007-9-33
- Chou, Tsui-Fen and Deshaies, Raymond J. (2011) Quantitative
Cell-based Protein Degradation Assays to Identify and Classify Drugs
That Target the Ubiquitin-Proteasome System; Journal of Biological
Chemistry; Vol. 286; No. 19; 16546-16554; PMCID PMC3089497; 10.1074/jbc.M110.215319
- Lee, J. Eugene; Sweredoski, Michael J.; et el. (2011) The
steady-state repertoire of human SCF Ubiquitin ligase complexes does not
require ongoing Nedd8 conjugation; Molecular and Cellular
Proteomics; Vol. 10; No. 5; Art. No. M110.006460; PMCID PMC3098594; 10.1074/mcp.M110.006460
- Saha, Anjanabha; Lewis, Steven; et el. (2011) Essential
Role for Ubiquitin-Ubiquitin-Conjugating Enzyme Interaction in Ubiquitin
Discharge from Cdc34 to Substrate; Molecular Cell; Vol. 42; No. 1;
75-83; PMCID PMC3091889; 10.1016/j.molcel.2011.03.016
- Chou, Tsui-Fen; Brown, Steve J.; et el. (2011) Reversible
inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic
protein clearance pathways; Proceedings of the National Academy of
Sciences of the United States of America; Vol. 108; No. 12; 4834-4839;
PMCID PMC3064330; 10.1073/pnas.1015312108
- Verma, Rati; Oania, Robert; et el. (2011) Cdc48/p97
Mediates UV-Dependent Turnover of RNA Pol II; Molecular Cell; Vol.
41; No. 1; 82-92; PMCID PMC3063307; 10.1016/j.molcel.2010.12.017
- Chou, T. and Deshaies, R. (2010) Development
of p97 inhibitors as potential anti-cancer therapeutics
- Tyrrell, An; Flick, Karin; et el. (2010) Physiologically
relevant and portable tandem ubiquitin-binding domain stabilizes
polyubiquitylated proteins; Proceedings of the National Academy of
Sciences of the United States of America; Vol. 107; No. 46; 19796-19801;
PMCID PMC2993400; 10.1073/pnas.1010648107
- Collins, Galen A.; Gomez, Tara Adele; et el. (2010) Combined
chemical and genetic approach to inhibit proteolysis by the
proteasome; Yeast; Vol. 27; No. 11; 965-974; PMCID PMC3566228; 10.1002/yea.1805
- Aghajan, Mariam; Jonai, Nao; et el. (2010) Chemical
genetics screen for enhancers of rapamycin identifies a specific
inhibitor of an SCF family E3 ubiquitin ligase; Nature
Biotechnology; Vol. 28; No. 7; 738-742; PMCID PMC2902569; 10.1038/nbt.1645
- Radhakrishnan, Senthil K.; Lee, Candy S.; et el. (2010) Transcription
Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome
Inhibition in Mammalian Cells; Molecular Cell; Vol. 38; No. 1;
17-28; PMCID PMC2874685; 10.1016/j.molcel.2010.02.029
- Kleiger, Gary; Hao, Bing; et el. (2009) The
Acidic Tail of the Cdc34 Ubiquitin-conjugating Enzyme Functions in Both
Binding to and Catalysis with Ubiquitin Ligase SCFC^(dc4*); Journal
of Biological Chemistry; Vol. 284; No. 52; 36012-36023; PMCID
PMC2794717; 10.1074/jbc.M109.058529
- Pierce, Nathan W.; Kleiger, Gary; et el. (2009) Detection
of sequential polyubiquitylation on a millisecond timescale; Nature;
Vol. 462; No. 7273; 615-620; PMCID PMC2791906; 10.1038/nature08595
- Kleiger, Gary; Saha, Anjanabha; et el. (2009) Rapid
E2-E3 Assembly and Disassembly Enable Processive Ubiquitylation of
Cullin-RING Ubiquitin Ligase Substrates; Cell; Vol. 139; No. 5;
957-968; PMCID PMC2804849; 10.1016/j.cell.2009.10.030
- Collins, Galen A.; Lipford, J. Russell; et el. (2009) Gal4
turnover and transcription activation; Nature; Vol. 461; No. 7265;
E7-E8; PMCID PMC3072683; 10.1038/nature08406
- Deshaies, Raymond J. and Joazeiro, Claudio A. P. (2009) RING
domain E3 ubiquitin ligases; Annual Review of Biochemistry; Vol. 78;
399-434; 10.1146/annurev.biochem.78.101807.093809
- Deshaies, Raymond J. (2009) Drug
discovery: fresh target for cancer therapy; Nature; Vol. 458;
No. 7239; 709-710; 10.1038/458709a
- Oh, Young Mi; Kwon, Young Eun; et el. (2009) Chfr
is linked to tumour metastasis through the downregulation of HDAC1;
Nature Cell Biology; Vol. 11; No. 3; 295-302; 10.1038/ncb1837
- Mohl, Dane A.; Huddleston, Michael J.; et el. (2009) Dbf2-Mob1
drives relocalization of protein phosphatase Cdc14 to the cytoplasm
during exit from mitosis; Journal of Cell Biology; Vol. 184; No. 4;
527-539; PMCID PMC2654127; 10.1083/jcb.200812022
- Machida, Keigo; Tsukamoto, Hidekazu; et el. (2009) Toll-like
receptor 4 mediates synergism between alcohol and HCV in hepatic
oncogenesis involving stem cell marker Nanog; Proceedings of the
National Academy of Sciences of the United States of America; Vol. 106;
No. 5; 1548-1553; PMCID PMC2635765; 10.1073/pnas.0807390106
- Rodriguez-Gonzalez, A.; Cyrus, K.; et el. (2008) Targeting
steroid hormone receptors for ubiquitination and degradation in breast
and prostate cancer; Oncogene; Vol. 27; No. 57; 7201-7211; PMCID
PMC5573236; 10.1038/onc.2008.320
- Saha, Anjanabha and Deshaies, Raymond J. (2008) Multimodal
activation of the ubiquitin ligase SCF by Nedd8 conjugation;
Molecular Cell; Vol. 32; No. 1; 21-31; PMCID PMC2644375; 10.1016/j.molcel.2008.08.021
- Sakamoto, K.; Rodriguez-Gonzalez, A.; et el. (2008) Targeting
steroid hormone receptors for ubiquitination and degradation in breast
and prostate cancer; European Journal of Cancer Supplements; Vol. 6;
No. 12; 16; 10.1016/S1359-6349(08)71971-2
- Goh, Amanda M.; Walters, Kylie J.; et el. (2008) Components
of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family
proteins; BMC Biochemistry; Vol. 9; Art. No. 4; PMCID PMC2267792; 10.1186/1471-2091-9-4
- Mayor, Thibault; Graumann, Johannes; et el. (2007) Quantitative
Profiling of Ubiquitylated Proteins Reveals Proteasome Substrates and
the Substrate Repertoire Influenced by the Rpn10 Receptor Pathway;
Molecular and Cellular Proteomics; Vol. 6; No. 11; 1885-1895; 10.1074/mcp.M700264-MCP200
- Ghaboosi, Nazli and Deshaies, Raymond J. (2007) A
Conditional Yeast E1 Mutant Blocks the Ubiquitin–Proteasome Pathway and
Reveals a Role for Ubiquitin Conjugates in Targeting Rad23 to the
Proteasome; Molecular Biology of the Cell; Vol. 18; No. 5;
1953-1963; PMCID PMC1855034; 10.1091/mbc.E06-10-0965
- Sharon, Michal; Taverner, Thomas; et el. (2006) Structural
Organization of the 19S Proteasome Lid: Insights from MS of Intact
Complexes; PLoS Biology; Vol. 4; No. 8; e267; PMCID PMC1523230
- Cope, Gregory A. and Deshaies, Raymond J. (2006) Targeted
silencing of Jab1/Csn5 in human cells downregulates SCF activity through
reduction of F-box protein levels; BMC Biochemistry; Vol. 7; Art.
No. 1; PMCID PMC1360668; 10.1186/1471-2091-7-1
- Lipford, J. Russell; Smith, Geoffrey T.; et el. (2005) A
putative stimulatory role for activator turnover in gene expression;
Nature; Vol. 438; No. 7064; 113-116; 10.1038/nature04098
- Mah, Angie S.; Elia, Andrew E. H.; et el. (2005) Substrate
specificity analysis of protein kinase complex Dbf2-Mob1 by peptide
library and proteome array screening; BMC Biochemistry; Vol. 6; Art.
No. 22; PMCID PMC1277818; 10.1186/1471-2091-6-22
- Mayor, Thibault; Lipford, J. Russell; et el. (2005) Analysis of
polyubiquitin conjugates reveals that the Rpn10 substrate receptor
contributes to the turnover of multiple proteasome targets;
Molecular and Cellular Proteomics; Vol. 4; No. 6; 741-751; 10.1074/mcp.M400220-MCP200
- Petroski, Matthew D. and Deshaies, Raymond J. (2005) Function
and regulation of Cullin-RING ubiquitin ligases; Nature Reviews.
Molecular Cell Biology; Vol. 6; No. 1; 9-20; 10.1038/nrm1547
- Deshaies, Raymond (2004) Varshavsky’s
Contributions; Science; Vol. 306; No. 5700; 1290-1292; 10.1126/science.306.5700.1290
- Verma, Rati; Peters, Noel R.; et el. (2004) Ubistatins
Inhibit Proteasome-Dependent Degradation by Binding the Ubiquitin
Chain; Science; Vol. 306; No. 5693; 117-120; 10.1126/science.1100946
- Azzam, Ramzi; Chen, Susan L.; et el. (2004) Phosphorylation
by Cyclin B-Cdk Underlies Release of Mitotic Exit Activator Cdc14 from
the Nucleolus; Science; Vol. 305; No. 5683; 516-519; 10.1126/science.1099402
- Schneekloth, John S., Jr.; Fonseca, Fabiana N.; et el. (2004) Chemical
Genetic Control of Protein Levels: Selective in Vivo Targeted
Degradation; Journal of the American Chemical Society; Vol. 126;
No. 12; 3748-3754; 10.1021/ja039025z
- Graumann, Johannes; Dunipace, Leslie A.; et el. (2004) Applicability
of tandem affinity purification MudPIT to pathway proteomics in
yeast; Molecular and Cellular Proteomics; Vol. 3; No. 3; 226-237; 10.1074/mcp.M300099-MCP200
- Wertz, Ingrid E.; O’Rourke, Karen M.; et el. (2004) Human
De-Etiolated-1 Regulates c-Jun by Assembling a CUL4A Ubiquitin
Ligase; Science; Vol. 303; No. 5662; 1371-1374; 10.1126/science.1093549
- Ambroggio, Xavier I.; Rees, Douglas C.; et el. (2004) JAMM: A
Metalloprotease-Like Zinc Site in the Proteasome and Signalosome;
PLoS Biology; Vol. 2; No. 1; 113-119; PMCID PMC300881; 10.1371/journal.pbio.0020002
- Sakamoto, Kathleen M.; Kim, Kyung B.; et el. (2003) Development
of Protacs to Target Cancer-promoting Proteins for Ubiquitination and
Degradation; Molecular and Cellular Proteomics; Vol. 2; No. 12;
1350-1358; 10.1074/mcp.T300009-MCP200
- Lipford, J. Russell and Deshaies, Raymond J. (2003) Diverse
roles for ubiquitin-dependent proteolysis in transcriptional
activation; Nature Cell Biology; Vol. 5; No. 10; 845-850; 10.1038/ncb1003-845
- Cope, Gregory A.; Suh, Greg S.; et el. (2002) Role
of Predicted Metalloprotease Motif of Jab1/Csn5 in Cleavage of Nedd8
from Cul1; Science; Vol. 298; No. 5593; 608-611; 10.1126/science.1075901
- Verma, Rati; Aravind, L.; et el. (2002) Role
of Rpn11 Metalloprotease in Deubiquitination and Degradation by the 26S
Proteasome; Science; Vol. 298; No. 5593; 611-615; 10.1126/science.1075898
- Shou, Wenying; Azzam, Ramzi; et el. (2002) Cdc5
influences phosphorylation of Net1 and disassembly of the RENT
complex; BMC Molecular Biology; Vol. 3; No. 3; 1-14; PMCID
PMC113746
- Shou, Wenying and Deshaies, Raymond J. (2002) Multiple
telophase arrest bypassed (tab) mutants alleviate the essential
requirement for Cdc15 in exit from mitosis in S. cerevisiae; BMC
Genetics; Vol. 3; Art. No. 4; PMCID PMC102333; 10.1186/1471-2156-3-4
- Chen, Susan Loughery; Huddleston, Michael J.; et el. (2002) Mass
Spectrometry-based Methods for Phosphorylation Site Mapping of
Hyperphosphorylated Proteins Applied to Net1, a Regulator of Exit from
Mitosis in Yeast; Molecular and Cellular Proteomics; Vol. 1; No. 3;
186-196; 10.1074/mcp.M100032-MCP200
- Deshaies, Raymond J.; Seol, Jae Hong; et el. (2002) Charting the
protein complexome in yeast by mass spectrometry; Molecular and
Cellular Proteomics; Vol. 1; No. 1; 3-10; 10.1074/mcp.R100001-MCP200
- Wu, Guangyu; Lyapina, Svetlana; et el. (2001) SEL-10 Is an
Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated
Protein Degradation; Molecular and Cellular Biology; Vol. 21;
No. 21; 7403-7415; PMCID PMC99913; 10.1128/MCB.21.21.7403-7415.2001
- Zhou, Chunshui; Seibert, Volker; et el. (2001) The fission
yeast COP9/signalosome is involved in cullin modification by
ubiquitin-related Ned8p; BMC Biochemistry; Vol. 2; No. 7; 1-11;
PMCID PMC37391; 10.1186/1471-2091-2-7
- Sakamoto, Kathleen M.; Kim, Kyung B.; et el. (2001) Protacs:
Chimeric molecules that target proteins to the Skp1-Cullin-F box complex
for ubiquitination and degradation; Proceedings of the National
Academy of Sciences of the United States of America; Vol. 98; No. 15;
8554-8559; PMCID PMC37474; 10.1073/pnas.141230798
- Mah, Angie S.; Jang, Joanne; et el. (2001) Protein
kinase Cdc15 activates the Dbf2-Mob1 kinase complex; Proceedings of
the National Academy of Sciences of the United States of America; Vol.
98; No. 13; 7325-7330; PMCID PMC34667; 10.1073/pnas.141098998
- Traverso, Edwin E.; Baskerville, Christopher; et el. (2001) Characterization
of the Net1 cell cycle-dependent regulator of the Cdc14 phosphatase from
budding yeast; Journal of Biological Chemistry; Vol. 276; No. 24;
21924-21931; 10.1074/jbc.M011689200
- Schwechheimer, Claus; Serino, Giovanna; et el. (2001) Interactions
of the COP9 Signalosome with the E3 Ubiquitin Ligase SCF^(TIR1) in
Mediating Auxin Response; Science; Vol. 292; No. 5520; 1379-1382; 10.1126/science.1059776
- Lyapina, Svetlana; Cope, Gregory; et el. (2001) Promotion
of NEDD8-CUL1 Conjugate Cleavage by COP9 Signalosome; Science; Vol.
292; No. 5520; 1382-1385; 10.1126/science.1059780
- Galan, Jean-Marc; Wiederkehr, Andreas; et el. (2001) Skp1p and
the F-Box Protein Rcy1p Form a Non-SCF Complex Involved in Recycling of
the SNARE Snc1p in Yeast; Molecular and Cellular Biology; Vol. 21;
No. 9; 3105-3117; PMCID PMC86938; 10.1128/MCB.21.9.3105-3117.2001
- Seol, Jae Hong; Shevchenko, Anna; et el. (2001) Skp1
forms multiple protein complexes, including RAVE, a regulator of
V-ATPase assembly; Nature Cell Biology; Vol. 3; No. 4; 384-391; 10.1038/35070067
- Annan, Roland S.; Huddleston, Michael J.; et el. (2001) A
Multidimensional Electrospray MS-Based Approach to Phosphopeptide
Mapping; Analytical Chemistry; Vol. 73; No. 3; 393-404; 10.1021/ac001130t
- Verma, Rati; Chen, Stephen; et el. (2000) Proteasomal
Proteomics: Identification of Nucleotide-sensitive
Proteasome-interacting Proteins by Mass Spectrometric Analysis of
Affinity-purified Proteasomes; Molecular Biology of the Cell; Vol.
11; No. 10; 3425-3439; PMCID PMC15004
- Reynard, Gregory J.; Reynolds, William; et el. (2000) Cks1 Is
Required for G1 Cyclin-Cyclin-Dependent Kinase Activity in Budding
Yeast; Molecular and Cellular Biology; Vol. 20; No. 16; 5858-5864;
PMCID PMC86063
- Deshaies, Raymond J. and Meyerowitz, Elliot M. (2000) COP1
patrols the night beat; Nature Cell Biology; Vol. 2; No. 6;
E102-E104; 10.1038/35014095
- Deshaies, R. J. (1999) SCF
and Cullin/RING H2-based ubiquitin ligases; Annual Review of Cell
and Developmental Biology; Vol. 15; 435-467; 10.1146/annurev.cellbio.15.1.435
- Lyapina, Svetlana A.; Correll, Craig C.; et el. (1998) Human CUL1
forms an evolutionarily conserved ubiquitin ligase complex (SCF) with
SKP1 and an F-box protein; Proceedings of the National Academy of
Sciences of the United States of America; Vol. 95; No. 13; 7451-7456;
PMCID PMC22647
- Verma, R.; Annan, R. S.; et el. (1997) Phosphorylation
of Sic1p by G_1 Cdk Required for Its Degradation and Entry into S
Phase; Science; Vol. 278; No. 5337; 455-460; 10.1126/science.278.5337.455
- Verma, Rati; Feldman, R. M. Renny; et el. (1997) SIC1 is
ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and
cyclin/CDK activities; Molecular Biology of the Cell; Vol. 8; No. 8;
1427-1437; PMCID PMC276167
- King, Randall W.; Deshaies, Raymond J.; et el. (1996) How
Proteolysis Drives the Cell Cycle; Science; Vol. 274; No. 5293;
1652-1659; 10.1126/science.274.5293.1652
- Banerjee, Amit; Deshaies, Raymond J.; et el. (1995) Characterization
of a Dominant Negative Mutant of the Cell Cycle Ubiquitin-conjugating
Enzyme Cdc34; Journal of Biological Chemistry; Vol. 270; No. 44;
26209-26215