(orcid 0000-0002-0021-889X)
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Fry, Michelle Y.; Saladi, Shyam M. et al. (2021) The STI1-domain is a flexible alpha‐helical fold with a hydrophobic groove Protein Science; Vol. 30; No. 4; https://doi.org/10.1002/pro.4049
Lin, Ku-Feng; Fry, Michelle Y. et al. (2021) Molecular basis of tail-anchored integral membrane protein recognition by the cochaperone Sgt2 Journal of Biological Chemistry; Vol. 296; https://doi.org/10.1016/j.jbc.2021.100441
Mitachi, Katsuhiko; Kansal, Rita G. et al. (2020) DPAGT1 Inhibitors of Capuramycin Analogues and Their Antimigratory Activities of Solid Tumors Journal of Medicinal Chemistry; Vol. 63; No. 19; https://doi.org/10.1021/acs.jmedchem.0c00545
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Yun, Hyun Gi; Jang, Kyoung-Soon et al. (2020) The structure of the UDP-Glc/GlcNAc 4-epimerase from the human pathogen Campylobacter jejuni https://doi.org/10.1101/2020.09.22.308395
Mitachi, Katsuhiko; Yun, Hyun Gi et al. (2020) Substrate Tolerance of Bacterial Glycosyltransferase MurG: Novel Fluorescence-based Assays ACS Infectious Diseases; Vol. 6; No. 6; https://doi.org/10.1021/acsinfecdis.9b00242
Mitachi, Katsuhiko; Kurosu, Shou M. et al. (2019) A practical synthesis of a novel DPAGT1 inhibitor, aminouridyl phenoxypiperidinbenzyl butanamide (APPB) for in vivo studies MethodsX; Vol. 6; https://doi.org/10.1016/j.mex.2019.09.031
Mitachi, Katsuhiko; Kurosu, Shou M. et al. (2019) Semisynthesis of an Anticancer DPAGT1 Inhibitor from a Muraymycin Biosynthetic Intermediate Organic Letters; Vol. 21; No. 4; https://doi.org/10.1021/acs.orglett.8b03716
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Saladi, Shyam M.; Javed, Nauman et al. (2018) A statistical model for improved membrane protein expression using sequence-derived features Journal of Biological Chemistry; Vol. 293; No. 13; https://doi.org/10.1074/jbc.RA117.001052
Mitachi, Katsuhiko; Yun, Hyun Gi et al. (2018) Novel FR-900493 Analogues That Inhibit the Outgrowth of Clostridium difficile Spores ACS Omega; Vol. 3; No. 2; https://doi.org/10.1021/acsomega.7b01740
Fry, Michelle Y.; Clemons, William M., Jr. (2018) Complexity in targeting membrane proteins Science; Vol. 359; No. 6374; https://doi.org/10.1126/science.aar5992
Niesen, Michiel J. M.; Marshall, Stephen S. et al. (2017) Improving membrane protein expression by optimizing integration efficiency Journal of Biological Chemistry; Vol. 292; No. 47; https://doi.org/10.1074/jbc.M117.813469
Mock, Jee-Young; Xu, Yue et al. (2017) Structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35 Proceedings of the National Academy of Sciences of the United States of America; Vol. 114; No. 44; https://doi.org/10.1073/pnas.1702940114
Schulte, Samuel J.; Saladi, Shyam et al. (2017) Predicting Membrane Protein Expression in Yeast from Sequence-Derived Features Biophysical Journal; Vol. 112; No. 3; In: 58th Annual Meeting of the Biophysical-Society, 15-19 February 2014, San Francisco, CA https://doi.org/10.1016/j.bpj.2016.11.1928
Clemons, Bil (2017) Solving the Membrane Protein Expression Problem Biophysical Journal; Vol. 112; No. 3; In: 58th Annual Meeting of the Biophysical-Society, February 15-19, 2014, San Francisco, CA https://doi.org/10.1016/j.bpj.2016.11.1783
Saladi, Shyam; Chu, Alexander E. et al. (2017) Statistical Models Robustly Predict Membrane Protein Expression in E. Coli Biophysical Journal; Vol. 112; No. 3; In: 58th Annual Meeting of the Biophysical-Society, 15-19 February 2014, San Francisco, CA https://doi.org/10.1016/j.bpj.2016.11.1929
Chu, Alexander E.; Saladi, Shyam M. et al. (2017) Towards a Universal Characterization of the Membrane Protein Expression Landscape Biophysical Journal; Vol. 112; No. 3, Supp. 1; In: 61st Annual Meeting of the Biophysical-Society, 11-15 February 2017, New Orleans, LA https://doi.org/10.1016/j.bpj.2016.11.1046
Saladi, Shyam M.; Javed, Nauman et al. (2017) Decoding sequence-level information to predict membrane protein expression https://doi.org/10.1101/098673
Yun, Hyun Gi; Jang, Kyoung-Soon et al. (2016) The Structure of the UDP-Glc/GlcNAc 4-Epimerase from the Human Pathogen Campylobacter jejuni Glycobiology; Vol. 26; No. 12; In: 2016 Annual Meeting of the Society-for-Glycobiology, 19-22 November 2016, New Orleans, LA https://doi.org/10.1093/glycob/cww110
Marshall, Stephen S.; Niesen, Michiel J. M. et al. (2016) A Link between Integral Membrane Protein Expression and Simulated Integration Efficiency Cell Reports; Vol. 16; No. 8; https://doi.org/10.1016/j.celrep.2016.07.042
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Saladi, Shyam M.; Javed, Nauman et al. (2016) A Machine Learning Approach to Heterologous Membrane Protein Overexpression Biophysical Journal; Vol. 110; No. 3; In: 60th Annual Meeting of the Biophysical-Society, 27 February-2 March 2016, Los Angeles, CA https://doi.org/10.1016/j.bpj.2015.11.278
Lin, Ku-Feng; Clemons, William M. (2016) Promiscuous Binding of Membrane Proteins on Flexible Co-Chaperones, Yeast Sgt2 and Human SGTA Biophysical Journal; Vol. 110; No. 3; In: 60th Annual Meeting of the Biophysical-Society, February 27-March 2, 2016, Los Angeles, CA https://doi.org/10.1016/j.bpj.2015.11.2994
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Jang, Kyoung-Soon; Nani, Roger R. et al. (2015) A cationic cysteine-hydrazide as an enrichment tool for the mass spectrometric characterization of bacterial free oligosaccharides Analytical and Bioanalytical Chemistry; Vol. 407; No. 20; https://doi.org/10.1007/s00216-015-8798-8
Mock, Jee-Young; Clemons, William M., Jr. (2015) Capturing the signal eLife; Vol. 2015; No. 4; https://doi.org/10.7554/eLife.09315
Mitachi, Katsuhiko; Siricilla, Shajila et al. (2015) Chemoenzymatic syntheses of water-soluble lipid I fluorescent probes Tetrahedron Letters; Vol. 56; No. 23; https://doi.org/10.1016/j.tetlet.2015.01.044
Mock, Jee-Young; Chartron, Justin William et al. (2015) Bag6 complex contains a minimal tail-anchor–targeting module and a mock BAG domain Proceedings of the National Academy of Sciences of the United States of America; Vol. 112; No. 1; https://doi.org/10.1073/pnas.1402745112
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Gristick, Harry B.; Rao, Meera et al. (2014) Crystal structure of ATP-bound Get3–Get4–Get5 complex reveals regulation of Get3 by Get4 Nature Structural & Molecular Biology; Vol. 21; No. 5; https://doi.org/10.1038/nsmb.2813
Gristick, Harry; Rao, Meera et al. (2014) The structure of a tail-anchor membrane protein-binding complex reveals the regulation of Get3 by Get4 FASEB Journal; Vol. 28; No. 1; https://resolver.caltech.edu/CaltechAUTHORS:20150204-084954787
Jang, Kyoung-Soon; Sweredoski, Michael J. et al. (2014) Comprehensive proteomic profiling of outer membrane vesicles from Campylobacter jejuni Journal of Proteomics; Vol. 98; https://doi.org/10.1016/j.jprot.2013.12.014
Liu, Yanfen; Soetandyo, Nia et al. (2014) USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation eLife; Vol. 2014; No. 3; https://doi.org/10.7554/eLife.01369
Rome, Michael E.; Rao, Meera et al. (2013) Precise timing of ATPase activation drives targeting of tail-anchored proteins Proceedings of the National Academy of Sciences of the United States of America; Vol. 110; No. 19; https://doi.org/10.1073/pnas.1222054110
Ramasamy, Sureshkumar; Abrol, Ravinder et al. (2013) The Glove-like Structure of the Conserved Membrane Protein TatC Provides Insight into Signal Sequence Recognition in Twin-Arginine Translocation Structure; Vol. 21; No. 5; https://doi.org/10.1016/j.str.2013.03.004
Rao, Meera; Rome, Michael E. et al. (2013) Precise Timing of ATPase Activation Drives Targeting of Tail-Anchored Proteins Biophysical Journal; Vol. 104; No. 2; In: 57th Annual Meeting of the Biophysical-Society, February 2-6, 2013, Philadelphia, PA https://doi.org/10.1016/j.bpj.2012.11.3178
Chartron, Justin W.; VanderVelde, David G. et al. (2012) Structures of the Sgt2/SGTA Dimerization Domain with the Get5/UBL4A UBL Domain Reveal an Interaction that Forms a Conserved Dynamic Interface Cell Reports; Vol. 2; No. 6; https://doi.org/10.1016/j.celrep.2012.10.010
Tanaka, Shiho; Clemons, William M., Jr. (2012) Minimal requirements for inhibition of MraY by lysis protein E from bacteriophage ΦX174 Molecular Microbiology; Vol. 85; No. 5; https://doi.org/10.1111/j.1365-2958.2012.08153.x
Clemons, Bil; Chartron, Justin et al. (2012) Higher order assemblies in the GET membrane protein-targeting pathway Protein Science; Vol. 21; No. S1; In: 26th Annual Symposium of the Protein-Society, August 5-8, 2012, San Diego, CA https://resolver.caltech.edu/CaltechAUTHORS:20120827-142449938
Mock, Jeeyoung; Chartron, Justin et al. (2012) The Structural and Biochemical Characterization of Members of the Mammalian TA Protein Sorting Complex Protein Science; Vol. 21; No. S1; In: 26th Annual Symposium of the Protein-Society, August 5-8, 2012, San Diego, CA https://doi.org/10.1002/pro.2113
Clemons, William; Chartron, Justin et al. (2012) Higher order assemblies in the GET membrane protein targeting pathway FASEB Journal; Vol. 26; In: 2012 Experimental Biology Meeting, April 21-25, 2012, San Diego, CA https://resolver.caltech.edu/CaltechAUTHORS:20121220-145221698
Chartron, Justin William; Clemons, William M., Jr. (2012) Structural investigations of the Get4/Get5/Sgt2 complex FASEB Journal; Vol. 26; In: 2012 Experimental Biology Meeting, April 21-25, 2012, San Diego, CA https://resolver.caltech.edu/CaltechAUTHORS:20121220-111134355
Chartron, Justin W.; Clemons, William M., Jr. et al. (2012) The complex process of GETting tail-anchored membrane proteins to the ER Current Opinion in Structural Biology; Vol. 22; No. 2; https://doi.org/10.1016/j.sbi.2012.03.001
Chartron, Justin W.; VanderVelde, David G. et al. (2012) Get5 Carboxyl-terminal Domain Is a Novel Dimerization Motif That Tethers an Extended Get4/Get5 Complex Journal of Biological Chemistry; Vol. 287; No. 11; https://doi.org/10.1074/jbc.M111.333252
Suloway, Christian J. M.; Rome, Michael E. et al. (2012) Tail-anchor targeting by a Get3 tetramer: the structure of an archaeal homologue EMBO Journal; Vol. 31; No. 3; https://doi.org/10.1038/emboj.2011.433
Chartron, Justin W.; Gonzalez, Grecia M. et al. (2011) A Structural Model of the Sgt2 Protein and Its Interactions with Chaperones and the Get4/Get5 Complex Journal of Biological Chemistry; Vol. 286; No. 39; https://doi.org/10.1074/jbc.M111.277798
Chartron, Justin W.; Suloway, Christian J. M. et al. (2010) Structural characterization of the Get4/Get5 complex and its interaction with Get3 Proceedings of the National Academy of Sciences of the United States of America; Vol. 107; No. 27; https://doi.org/10.1073/pnas.1006036107
Suloway, Christian J. M.; Chartron, Justin W. et al. (2009) Model for eukaryotic tail-anchored protein binding based on the structure of Get3 Proceedings of the National Academy of Sciences of the United States of America; Vol. 106; No. 35; https://doi.org/10.1073/pnas.0907522106
Ramasamy, Suresh Kumar; Clemons, William M. (2009) Structure of the twin-arginine signal-binding protein DmsD from Escherichia coli Acta Crystallographica. Section F, Structural Biology and Crystallization Communications; Vol. 65; No. 8; https://doi.org/10.1107/S1744309109023811
Ménétret, Jean-François; Schaletzky, Julia et al. (2007) Ribosome Binding of a Single Copy of the SecY Complex: Implications for Protein Translocation Molecular Cell; Vol. 28; No. 6; https://doi.org/10.1016/j.molcel.2007.10.034
Smith, Margaret A.; Clemons, William M., Jr. et al. (2005) Modeling the Effects of prl Mutations on the Escherichia coli SecY Complex Journal of Bacteriology; Vol. 187; No. 18; https://doi.org/10.1128/JB.187.18.6454-6465.2005
Cannon, Kurt S.; Or, Eran et al. (2005) Disulfide bridge formation between SecY and a translocating polypeptide localizes the translocation pore to the center of SecY Journal of Cell Biology; Vol. 169; No. 2; https://doi.org/10.1083/jcb.200412019
Clemons, William M., Jr.; Ménétret, Jean-François et al. (2004) Structural insight into the protein translocation channel Current Opinion in Structural Biology; Vol. 14; No. 4; https://doi.org/10.1016/j.sbi.2004.07.006
Osborne, Andrew R.; Clemons, William M., Jr. et al. (2004) A large conformational change of the translocation ATPase SecA Proceedings of the National Academy of Sciences of the United States of America; Vol. 101; No. 30; https://doi.org/10.1073/pnas.0401742101
van den Berg, Bert; Black, Paul N. et al. (2004) Crystal Structure of the Long-Chain Fatty Acid Transporter FadL Science; Vol. 304; No. 5676; https://doi.org/10.1126/science.1097524
van den Berg, Bert; Clemons, William M., Jr. et al. (2004) X-ray structure of a protein-conducting channel Nature; Vol. 427; No. 6969; https://doi.org/10.1038/nature02218
Brodersen, D. E.; Clemons, W. M., Jr. et al. (2003) Phasing the 30S ribosomal subunit structure Acta Crystallographica Section D: Biological Crystallography; Vol. 59; No. 11; https://doi.org/10.1107/s0907444903017669
Brodersen, Ditlev E.; Clemons, William M., Jr. et al. (2002) Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16 S RNA Journal of Molecular Biology; Vol. 316; No. 3; https://doi.org/10.1006/jmbi.2001.5359
Clemons, William M., Jr.; Brodersen, Ditlev E. et al. (2001) Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: purification, crystallization and structure determination Journal of Molecular Biology; Vol. 310; No. 4; https://doi.org/10.1006/jmbi.2001.4778
Ogle, James M.; Brodersen, Ditlev E. et al. (2001) Recognition of Cognate Transfer RNA by the 30S Ribosomal Subunit Science; Vol. 292; No. 5518; https://doi.org/10.1126/science.1060612
Carter, Andrew P.; Clemons, William M., Jr. et al. (2001) Crystal Structure of an Initiation Factor Bound to the 30S Ribosomal Subunit Science; Vol. 291; No. 5503; https://doi.org/10.1126/science.1057766
Brodersen, D. E.; Carter, A. P. et al. (2001) Atomic Structures of the 30S Subunit and Its Complexes with Ligands and Antibiotics Cold Spring Harbor Symposia on Quantitative Biology; Vol. 66; https://doi.org/10.1101/sqb.2001.66.17
Brodersen, Ditlev E.; Clemons, William M., Jr. et al. (2000) Structural Basis for the Action of the Antibiotics Tetracycline, Pactamycin, and Hygromycin B on the 30S Ribosomal Subunit Cell; Vol. 103; No. 7; https://doi.org/10.1016/s0092-8674(00)00216-6
Carter, Andrew P.; Clemons, William M. et al. (2000) Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics Nature; Vol. 407; No. 6802; https://doi.org/10.1038/35030019
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Clemons, William M., Jr.; Gowda, Krishne et al. (1999) Crystal structure of the conserved subdomain of human protein SRP54M at 2.1 A resolution: evidence for the mechanism of signal peptide binding Journal of Molecular Biology; Vol. 292; No. 3; https://doi.org/10.1006/jmbi.1999.3090
Clemons, William M., Jr.; May, Joanna L. C. et al. (1999) Structure of a bacterial 30S ribosomal subunit at 5.5 Å resolution Nature; Vol. 400; No. 6747; https://doi.org/10.1038/23631
Gowda, Krishne; Clemons, William M., Jr. et al. (1999) Expression, purification, and crystallography of the conserved methionine-rich domain of human signal recognition particle 54 kda protein Protein Science; Vol. 8; No. 5; https://doi.org/10.1110/ps.8.5.1144
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Clemons, William M., Jr.; Davies, Christopher et al. (1998) Conformational variability of the N-terminal helix in the structure of ribosomal protein S15 Structure; Vol. 6; No. 4; https://doi.org/10.1016/s0969-2126(98)00045-8