- Yang, Zheng and Chan, David C. (2023) Control
of mitochondrial dynamics by a fusogenic lipid; Trends in Cell
Biology; 10.1016/j.tcb.2023.10.006
- Fry, Michelle Y.; Navarro, Paula P.; et el. (2023) In
situ architecture of Opa1-dependent mitochondrial cristae
remodeling; 10.1101/2023.01.16.524176
- Murata, Daisuke; Grunseich, Christopher; et el. (2023) A
Heterozygous Mutation in MFF Associated with a Mild Mitochondrial
Phenotype; Journal of Neuromuscular Diseases; Vol. 10; No. 1;
107-118; 10.3233/jnd-221532
- Dai, Wenting; Wang, Zhichao; et el. (2022) Metabolic
reprogramming in the OPA1-deficient cells; Cellular and Molecular
Life Sciences; Vol. 79; No. 10; Art. No. 517; 10.1007/s00018-022-04542-5
- Yang, Huan; Sibilla, Caroline; et el. (2022) Clueless/CLUH
regulates mitochondrial fission by promoting recruitment of Drp1 to
mitochondria; Nature Communications; Vol. 13; No. 1; Art. No. 1582;
10.1038/s41467-022-29071-4
- Wareham, Lauren K.; Liddelow, Shane A.; et el. (2022) Solving
neurodegeneration: common mechanisms and strategies for new
treatments; Molecular Neurodegeneration; Vol. 17; Art. No. 23; PMCID
PMC8935795; 10.1186/s13024-022-00524-0
- Sonn, Seong Keun; Seo, Seungwoon; et el. (2021) ER-associated
CTRP1 regulates mitochondrial fission via interaction with DRP1;
Experimental and Molecular Medicine; Vol. 53; 1769-1780; PMCID
PMC8639813; 10.1038/s12276-021-00701-z
- Varuzhanyan, Grigor; Ladinsky, Mark S.; et el. (2021) Fis1
ablation in the male germline disrupts mitochondrial morphology and
mitophagy, and arrests spermatid maturation; Development; Vol. 148;
No. 16; Art. No. dev199686; PMCID PMC8380467; 10.1242/dev.199686
- Varuzhanyan, Grigor; Chen, Hsiuchen; et el. (2021) Mitochondrial
fission factor (Mff) is required for organization of the mitochondrial
sheath in spermatids; Biochimica et Biophysica Acta - General
Subjects; Vol. 1865; No. 5; Art. No. 129845; PMCID PMC7904653; 10.1016/j.bbagen.2021.129845
- Wang, Ruohan; Mishra, Prashant; et el. (2021) Identification
of new OPA1 cleavage site reveals that short isoforms regulate
mitochondrial fusion; Molecular Biology of the Cell; Vol. 32; No. 2;
157-168; PMCID PMC8120690; 10.1091/mbc.e20-09-0605
- Shin, Chun-Shik; Meng, Shuxia; et el. (2021) LONP1
and mtHSP70 cooperate to promote mitochondrial protein folding;
Nature Communications; Vol. 12; Art. No. 265; PMCID PMC7801493; 10.1038/s41467-020-20597-z
- Kato, Mitsuo; Abdollahi, Maryam; et el. (2021) miR-379
deletion ameliorates features of diabetic kidney disease by enhancing
adaptive mitophagy via FIS1; Communications Biology; Vol. 4; Art.
No. 30; PMCID PMC7782535; 10.1038/s42003-020-01516-w
- Adachi, Yoshihiro; Kato, Takashi; et el. (2020) Drp1
Tubulates the ER in a GTPase-Independent Manner; Molecular Cell;
Vol. 80; No. 4; 621-632; PMCID PMC7680448; 10.1016/j.molcel.2020.10.013
- Varuzhanyan, Grigor and Chan, David C. (2020) Mitochondrial
dynamics during spermatogenesis; Journal of Cell Science; Vol. 133;
No. 14; Art. No. jcs235937; PMCID PMC7375475; 10.1242/jcs.235937
- Chan, David C. (2020) Mitochondrial
Dynamics and Its Involvement in Disease; Annual Review of Pathology:
Mechanisms of Disease; Vol. 15; 235-259; 10.1146/annurev-pathmechdis-012419-032711
- Mishra, Prashant; Zhang, Ting; et el. (2019) Mitochondrial
Respiratory Measurements in Patient-derived Fibroblasts;
Bio-protocol; Vol. 9; No. 23; Art. No. e3446; PMCID PMC7853990; 10.21769/bioprotoc.3446
- Li, Yu-Jie; Cao, Yu-Lu; et el. (2019) Structural
insights of human mitofusin-2 into mitochondrial fusion and CMT2A
onset; Nature Communications; Vol. 10; Art. No. 4914; PMCID
PMC6820788; 10.1038/s41467-019-12912-0
- Varuzhanyan, Grigor; Rojansky, Rebecca; et el. (2019) Mitochondrial
fusion is required for spermatogonial differentiation and meiosis;
eLife; Vol. 8; Art. No. e51601; PMCID PMC6805159; 10.7554/elife.51601
- Kehr, Andrew D.; Meng, Shuxia; et el. (2019) Advances
in the Structural and Biochemical Determination of Several Dynamin-Like
GTPases; Biophysical Journal; Vol. 116; No. 3; 473a; 10.1016/j.bpj.2018.11.2552
- Del Dotto, Valentina; Fogazza, Mario; et el. (2018) Deciphering
OPA1 mutations pathogenicity by combined analysis of human, mouse and
yeast cell models; Biochimica et Biophysica Acta - Molecular Basis
of Disease; Vol. 1864; No. 10; 3496-3514; 10.1016/j.bbadis.2018.08.004
- Guo, Yuxuan; Jardin, Blake D.; et el. (2018) Hierarchical
and stage-specific regulation of murine cardiomyocyte maturation by
serum response factor; Nature Communications; Vol. 9; Art. No. 3837;
PMCID PMC6155060; 10.1038/s41467-018-06347-2
- Ryan, Conor S.; Fine, Anthony L.; et el. (2018) De
Novo DNM1L Variant in a Teenager With Progressive Paroxysmal Dystonia
and Lethal Super-refractory Myoclonic Status Epilepticus; Journal of
Child Neurology; Vol. 33; No. 10; 651-658; 10.1177/0883073818778203
- Cha, Moon Yong; Chen, Hsiuchen; et el. (2018) Removal
of the Mitochondrial Fission Factor Mff Exacerbates Neuronal Loss and
Neurological Phenotypes in a Huntington’s Disease Mouse Model; PLOS
Currents; PMCID PMC6149597; 10.1371/currents.hd.a4e15b80c4915c828d39754942c6631f
- Jian, Fenglei; Chen, Dan; et el. (2018) Sam50
Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability
and Mitochondrial Morphology; Cell Reports; Vol. 23; No. 10;
2989-3005; 10.1016/j.celrep.2018.05.015
- Nemani, Neeharika; Carvalho, Edmund; et el. (2018) MIRO-1
Determines Mitochondrial Shape Transition upon GPCR Activation and
Ca^(2+) Stress; Cell Reports; Vol. 23; No. 4; 1005-1019; PMCID
PMC5973819; 10.1016/j.celrep.2018.03.098
- Chan, David C. (2018) Mitochondrial
fusion and fission in health and disease; Molecular Genetics and
Metabolism; Vol. 123; No. 3; 196; 10.1016/j.ymgme.2017.12.430
- Chan, David (2017) Molecular
Analysis Of Mitochondrial Dynamics; Free Radical Biology and
Medicine; Vol. 112; No. S1; 17; 10.1016/j.freeradbiomed.2017.10.371
- Li, J.; Lancaster, E.; et el. (2017) A
Rat Model of CMT2A Develops a Progressive Neuropathy; Journal of the
Peripheral Nervous System; Vol. 22; No. 3; 331; 10.1111/jns.12225
- Chen, Hsiuchen and Chan, David C. (2017) Mitochondrial
Dynamics in Regulating the Unique Phenotypes of Cancer and Stem
Cells; Cell Metabolism; Vol. 26; No. 1; 39-48; PMCID PMC5539982; 10.1016/j.cmet.2017.05.016
- Liu, Raymond and Chan, David C. (2017) OPA1
and cardiolipin team up for mitochondrial fusion; Nature Cell
Biology; Vol. 19; No. 7; 760-762; PMCID PMC5757513; 10.1038/ncb3565
- Del Dotto, Valentina; Mishra, Prashant; et el. (2017) OPA1
Isoforms in the Hierarchical Organization of Mitochondrial
Functions; Cell Reports; Vol. 19; No. 12; 2557-2571; 10.1016/j.celrep.2017.05.073
- Shin, Chun-Shik; Mishra, Prashant; et el. (2017) The
glutamate/cystine xCT antiporter antagonizes glutamine metabolism and
reduces nutrient flexibility; Nature Communications; Vol. 8; Art.
No. 15074; PMCID PMC5413954; 10.1038/ncomms15074
- Zhang, Ting; Mishra, Prashant; et el. (2017) Valosin-containing
protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial
defects due to VCP disease mutants; eLife; Vol. 6; Art. No. e17834;
PMCID PMC5360448; 10.7554/eLife.17834
- Cao, Yu-Lu; Meng, Shuxia; et el. (2017) MFN1
structures reveal nucleotide-triggered dimerization critical for
mitochondrial fusion; Nature; Vol. 542; No. 7641; 372-376; PMCID
PMC5319402; 10.1038/nature21077
- Chen, Hsiuchen and Chan, David (2017) Control
of Mitochondrial Function by Fusion and Fission; Biophysical
Journal; Vol. 112; No. 3, Supp. 1; 179a; 10.1016/j.bpj.2016.11.994
- Huang, R. E. and Chan, D. C. (2016) Investigating
the roles of Mulan and Fis1 in Mitophagy; Molecular Biology of the
Cell; Vol. 27; Art. No. P2161
- Rojansky, Rebecca; Cha, Moon-Yong; et el. (2016) Elimination
of paternal mitochondria in mouse embryos occurs through autophagic
degradation dependent on PARKIN and MUL1; eLife; Vol. 5; Art.
No. e17896; PMCID PMC5127638; 10.7554/eLife.17896
- Mishra, Prashant; Varuzhanyan, Grigor; et el. (2016) Regulation
of mitochondrial compartmentalization in skeletal muscle;
Mitochondrion; Vol. 31; 96; 10.1016/j.mito.2016.08.010
- Cheng, Chun-Ting; Kuo, Ching-Ying; et el. (2016) Metabolic
Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial
Fusion in Breast Cancer Cells; Cancer Research; Vol. 76; No. 17;
5006-5018; PMCID PMC5316485; 10.1158/0008-5472.CAN-15-2921
- Fahrner, Jill A.; Liu, Raymond; et el. (2016) A
novel de novo dominant negative mutation in DNM1L impairs mitochondrial
fission and presents as childhood epileptic encephalopathy; American
Journal of Medical Genetics Part A; Vol. 170; No. 8; 2002-2011; PMCID
PMC5100740; 10.1002/ajmg.a.37721
- Mishra, Prashant and Chan, David C. (2016) Metabolic
regulation of mitochondrial dynamics; Journal of Cell Biology; Vol.
212; No. 4; 379-387; PMCID PMC4754720; 10.1083/jcb.201511036
- Toyama, Erin Quan; Herzig, Sebastien; et el. (2016) AMP-activated
protein kinase mediates mitochondrial fission in response to energy
stress; Science; Vol. 351; No. 6270; 275-281; PMCID PMC4852862; 10.1126/science.aab4138
- Mishra, Prashant; Varuzhanyan, Grigor; et el. (2015) Mitochondrial
Dynamics Is a Distinguishing Feature of Skeletal Muscle Fiber Types and
Regulates Organellar Compartmentalization; Cell Metabolism; Vol. 22;
No. 6; 1033-1044; PMCID PMC4670593; 10.1016/j.cmet.2015.09.027
- Liu, Raymond and Chan, David C. (2015) The
mitochondrial fission receptor Mff selectively recruits oligomerized
Drp1; Molecular Biology of the Cell; Vol. 26; No. 24; 4466-4477;
PMCID PMC4666140; 10.1091/mbc.E15-08-0591
- Chen, Hsiuchen; Ren, Shuxun; et el. (2015) Titration
of mitochondrial fusion rescues Mff-deficient cardiomyopathy;
Journal of Cell Biology; Vol. 211; No. 4; 795-805; PMCID PMC4657172; 10.1083/jcb.201507035
- Hashimoto, Masami; Bacman, Sandra R.; et el. (2015) MitoTALENs:
A general approach to reduce mutant mtDNA loads and restore oxidative
phosphorylation function in mitochondrial diseases; Molecular
Therapy; Vol. 23; No. 10; 1592-1599; PMCID PMC4817924; 10.1038/mt.2015.126
- Losón, Oliver C.; Meng, Shuxia; et el. (2015) Crystal
structure and functional analysis of MiD49, a receptor for the
mitochondrial fission protein Drp1; Protein Science; Vol. 24; No. 3;
386-394; PMCID PMC4353364; 10.1002/pro.2629
- Carelli, Valerio and Chan, David C. (2014) Mitochondrial
DNA: Impacting Central and Peripheral Nervous Systems; Neuron; Vol.
84; No. 6; 1126-1142; PMCID PMC4271190; 10.1016/j.neuron.2014.11.022
- Mishra, Prashant and Chan, David C. (2014) Mitochondrial
dynamics and inheritance during cell division, development and
disease; Nature Reviews. Molecular Cell Biology; Vol. 15; No. 10;
634-646; PMCID PMC4250044; 10.1038/nrm3877
- Chan, Nickie C.; den Besten, Willem; et el. (2014) Degradation
of the Deubiquitinating Enzyme USP33 is Mediated by p97 and the
Ubiquitin Ligase HERC2; Journal of Biological Chemistry; Vol. 289;
No. 28; 19789-19798; PMCID PMC4094088; 10.1074/jbc.M114.569392
- Mishra, Prashant; Carelli, Valerio; et el. (2014) Proteolytic
Cleavage of Opa1 Stimulates Mitochondrial Inner Membrane Fusion and
Couples Fusion to Oxidative Phosphorylation; Cell Metabolism; Vol.
19; No. 4; 630-641; PMCID PMC4018240; 10.1016/j.cmet.2014.03.011
- Losn, Oliver; Rome, Michael; et el. (2014) Regulation
of mitochondrial fission by MiD51; FASEB Journal; Vol. 28; No. 1;
757.1
- Losón, Oliver C.; Liu, Raymond; et el. (2014) The
Mitochondrial Fission Receptor MiD51 Requires ADP as a Cofactor;
Structure; Vol. 22; No. 3; 367-377; PMCID PMC4066849; 10.1016/j.str.2014.01.001
- Samant, Sadhana A.; Zhang, Hannah J.; et el. (2014) SIRT3
Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics
during Stress; Molecular and Cellular Biology; Vol. 34; No. 5;
807-819; PMCID PMC4023816; 10.1128/MCB.01483-13
- Marinov, Georgi K.; Wang, Yun E.; et el. (2014) Evidence
for Site-Specific Occupancy of the Mitochondrial Genome by Nuclear
Transcription Factors; PLoS ONE; Vol. 9; No. 1; Art. No. e84713;
PMCID PMC3896368; 10.1371/journal.pone.0084713
- Ngo, Huu B.; Lovely, Geoffrey A.; et el. (2014) Distinct
structural features of TFAM drive mitochondrial DNA packaging versus
transcriptional activation; Nature Communications; Vol. 5; No. 1;
Art. No. 3077; PMCID PMC3936014; 10.1038/ncomms4077
- Pham, Anh H. and Chan, David C. (2014) Analyzing
Mitochondrial Dynamics in Mouse Organotypic Slice Cultures; ISBN
9780128016152; Mitochondrial Function; Academic Press: Amsterdam;
111-129; 10.1016/B978-0-12-801415-8.00007-2
- Wang, Yun E.; Marinov, Georgi K.; et el. (2013) Genome-Wide
Analysis Reveals Coating of the Mitochondrial Genome by TFAM; PLoS
ONE; Vol. 8; No. 8; Art. No. e74513; PMCID PMC3753274; 10.1371/journal.pone.0074513
- Losón, Oliver Calvin; Chen, Hsiuchen; et el. (2013) Fis1,
Mff, MiD49 and MiD51 facilitate Drp1 recruitment for mitochondrial
fission; FASEB Journal; Vol. 27; Art. No. 582.2
- Losón, Oliver C.; Song, Zhiyin; et el. (2013) Fis1,
Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial
fission; Molecular Biology of the Cell; Vol. 24; No. 5; 659-667;
PMCID PMC3583668; 10.1091/mbc.E12-10-0721
- Kim, Kook Hwan; Jeong, Yeon Taek; et el. (2013) Autophagy
deficiency leads to protection from obesity and insulin resistance by
inducing Fgf21 as a mitokine; Nature Medicine; Vol. 19; No. 1;
83-92; 10.1038/nm.3014
- Pham, Anh H.; Meng, Shuxia; et el. (2012) Loss
of Mfn2 results in progressive, retrograde degeneration of dopaminergic
neurons in the nigrostriatal circuit; Human Molecular Genetics; Vol.
21; No. 22; 4817-4826; PMCID PMC3607482; 10.1093/hmg/dds311
- Pham, Anh H.; McCaffery, J. Michael; et el. (2012) Mouse
lines with photo-activatable mitochondria to study mitochondrial
dynamics; Genesis; Vol. 50; No. 11; 833-843; PMCID PMC3508687; 10.1002/dvg.22050
- Chan, David C. (2012) Fusion
and Fission: Interlinked Processes Critical for Mitochondrial
Health; Annual Review of Genetics; Vol. 46; 265-287; 10.1146/annurev-genet-110410-132529
- Gautier, Clemente A.; Glaime, Emilie; et el. (2012) Regulation
of mitochondrial permeability transition pore by PINK1; Molecular
Neurodegeneration; Vol. 7; No. 1; Art. No. 22; PMCID PMC3405481; 10.1186/1750-1326-7-22
- Li, Jia; Liu, Xiaolei; et el. (2012) Lysocardiolipin
acyltransferase 1 (ALCAT1) controls mitochondrial DNA fidelity and
biogenesis through modulation of MFN2 expression; Proceedings of the
National Academy of Sciences of the United States of America; Vol. 109;
No. 18; 6975-6890; PMCID PMC3345005; 10.1073/pnas.1120043109
- Chan, David; Ngo, Huu B.; et el. (2012) Dynamics
of mitochondria and mitochondrial DNA; FASEB Journal; Vol. 26; Art.
No. 103.2
- Klionsky, Daniel J. and Chan, David C. (2012) Guidelines
for the use and interpretation of assays for monitoring autophagy;
Autophagy; Vol. 8; No. 4; 445-544; PMCID PMC3404883; 10.4161/auto.19496
- Zhang, Yan; Chan, Nickie C.; et el. (2012) Crystal
Structure of Mitochondrial Fission Complex Reveals Scaffolding Function
for Mitochondrial Division 1 (Mdv1) Coiled Coil; Journal of
Biological Chemistry; Vol. 287; No. 13; 9855-9861; PMCID PMC3323041; 10.1074/jbc.M111.329359
- Chan, David C. and Schon, Eric A. (2012) Eliminating
Mitochondrial DNA from Sperm; Developmental Cell; Vol. 22; No. 3;
469-470; PMCID PMC3995028; 10.1016/j.devcel.2012.02.008
- Ngo, Huu B.; Kaiser, Jens T.; et el. (2011) The
mitochondrial transcription and packaging factor Tfam imposes a U-turn
on mitochondrial DNA; Nature Structural & Molecular Biology;
Vol. 18; No. 11; 1290-1296; PMCID PMC3210390; 10.1038/nsmb.2159
- Chan, Nickie C. and Chan, David C. (2011) Parkin
uses the UPS to ship off dysfunctional mitochondria; Autophagy; Vol.
7; No. 7; 771-772; PMCID PMC3973655; 10.4161/auto.7.7.15453
- Chan, Nickie C.; Salazar, Anna M.; et el. (2011) Broad
activation of the ubiquitin-proteasome system by Parkin is critical for
mitophagy; Human Molecular Genetics; Vol. 20; No. 9; 1726-1737;
PMCID PMC3071670; 10.1093/hmg/ddr048
- Aravin, Alexei A. and Chan, David C. (2011) piRNAs
Meet Mitochondria; Developmental Cell; Vol. 20; No. 3; 287-288; 10.1016/j.devcel.2011.03.003
- Chen, Hsiuchen and Chan, David C. (2010) Physiological
functions of mitochondrial fusion; Annals of the New York Academy of
Sciences; Vol. 1201; 21-25; 10.1111/j.1749-6632.2010.05615.x
- Ban, Tadato; Heymann, Jürgen A. W.; et el. (2010) OPA1
disease alleles causing dominant optic atrophy have defects in
cardiolipin-stimulated GTP hydrolysis and membrane tubulation; Human
Molecular Genetics; Vol. 19; No. 11; 2113-2122; PMCID PMC2865371; 10.1093/hmg/ddq088
- Chen, Hsiuchen; Vermulst, Marc; et el. (2010) Mitochondrial
Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance
of mtDNA Mutations; Cell; Vol. 141; No. 2; 280-289; PMCID
PMC2876819; 10.1016/j.cell.2010.02.026
- Chen, Hsiuchen and Chan, David C. (2009) Mitochondrial
dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative
diseases; Human Molecular Genetics; Vol. 18; No. 2; R169-R176; 10.1093/hmg/ddp326
- Song, Zhiyin; Ghochani, Mariam; et el. (2009) Mitofusins
and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion;
Molecular Biology of the Cell; Vol. 20; No. 15; 3525-3532; PMCID
PMC2719570; 10.1091/mbc.E09-03-0252
- Tondera, Daniel; Grandemange, Stephanie; et el. (2009) SLP-2
is required for stress-induced mitochondrial hyperfusion; EMBO
Journal; Vol. 28; No. 11; 1589-1600; PMCID PMC2693158; 10.1038/emboj.2009.89
- Detmer, Scott A.; Vande Velde, Christine; et el. (2008) Hindlimb
gait defects due to motor axon loss and reduced distal muscles in a
transgenic mouse model of Charcot–Marie–Tooth type 2A; Human
Molecular Genetics; Vol. 17; No. 3; 367-375; 10.1093/hmg/ddm314
- Zhang, Yan and Chan, David C. (2007) Structural
basis for recruitment of mitochondrial fission complexes by Fis1;
Proceedings of the National Academy of Sciences of the United States of
America; Vol. 104; No. 47; 18526-18530; PMCID PMC2141810; 10.1073/pnas.0706441104
- Detmer, Scott A. and Chan, David C. (2007) Functions
and dysfunctions of mitochondrial dynamics; Nature Reviews.
Molecular Cell Biology; Vol. 8; No. 11; 870-879; 10.1038/nrm2275
- Song, Zhiyin; Chen, Hsiuchen; et el. (2007) OPA1
processing controls mitochondrial fusion and is regulated by mRNA
splicing, membrane potential, and Yme1L; Journal of Cell Biology;
Vol. 178; No. 5; 749-755; PMCID PMC2064540; 10.1083/jcb.200704110
- Chen, Hsiuchen; McCaffery, J. Michael; et el. (2007) Mitochondrial
Fusion Protects against Neurodegeneration in the Cerebellum; Cell;
Vol. 130; No. 3; 548-562; 10.1016/j.cell.2007.06.026
- Chan, David C. (2007) Mitochondrial
Dynamics in Disease; New England Journal of Medicine; Vol. 356;
No. 17; 1707-1709; 10.1056/NEJMp078040
- Detmer, Scott A. and Chan, David C. (2007) Complementation
between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused
by CMT2A disease mutations; Journal of Cell Biology; Vol. 170;
No. 4; 405-414; PMCID PMC2063976; 10.1083/jcb.200611080
- Choi, Seok-Yong; Huang, Ping; et el. (2006) A
common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated
exocytosis; Nature Cell Biology; Vol. 8; No. 11; 1255-1262; 10.1038/ncb1487
- Chan, David C. (2006) Mitochondrial
Fusion and Fission in Mammals; Annual Review of Cell and
Developmental Biology; Vol. 22; 79-99; 10.1146/annurev.cellbio.22.010305.104638
- Chen, Hsiuchen and Chan, David C. (2006) Critical
dependence of neurons on mitochondrial dynamics; Current Opinion in
Cell Biology; Vol. 18; No. 4; 453-459; 10.1016/j.ceb.2006.06.004
- Chan, David C. (2006) Mitochondria:
Dynamic Organelles in Disease, Aging, and Development; Cell; Vol.
125; No. 7; 1241-1252; 10.1016/j.cell.2006.06.010
- Griffin, Erik E. and Chan, David C. (2006) Domain
interactions within Fzo1 oligomers are essential for mitochondrial
fusion; Journal of Biological Chemistry; Vol. 281; No. 24;
16599-16606; 10.1074/jbc.M601847200
- Soriano, Franscesc X.; Liesa, Marc; et el. (2006) Evidence
for a Mitochondrial Regulatory Pathway Defined by Peroxisome
Proliferator–Activated Receptor-γ Coactivator-1α, Estrogen-Related
Receptor-α, and Mitofusin 2; Diabetes; Vol. 55; No. 6; 1783-1791; 10.2337/db05-0509
- Griffin, Erik E.; Detmer, Scott A.; et el. (2006) Molecular
mechanism of mitochondrial membrane fusion; Biochimica et Biophysica
Acta; Vol. 1763; No. 5-6; 482-489; 10.1016/j.bbamcr.2006.02.003
- Chan, D.; Frank, S.; et el. (2006) Mitochondrial
dynamics in cell life and death; Cell Death and Differentiation;
Vol. 13; No. 4; 680-684; 10.1038/sj.cdd.4401857
- Chen, Hsiuchen and Chan, David C. (2005) Emerging
functions of mammalian mitochondrial fusion and fission; Human
Molecular Genetics; Vol. 14; No. 2; R283-R289
- Griffin, Erik E.; Graumann, Johannes; et el. (2005) The WD40
protein Caf4p is a component of the mitochondrial fission machinery and
recruits Dnm1p to mitochondria; Journal of Cell Biology; Vol. 170;
No. 2; 237-248; PMCID PMC2171414; 10.1083/jcb.200503148
- Chen, Hsiuchen; Chomyn, Anne; et el. (2005) Disruption
of fusion results in mitochondrial heterogeneity and dysfunction;
Journal of Biological Chemistry; Vol. 280; No. 28; 26185-26192; 10.1074/jbc.M503062200
- Suntoke, Tara R. and Chan, David C. (2005) The Fusion
Activity of HIV-1 gp41 Depends on Interhelical Interactions; Journal
of Biological Chemistry; Vol. 280; No. 20; 19852-19857; 10.1074/jbc.M502196200
- Koshiba, Takumi; Detmer, Scott A.; et el. (2004) Structural
Basis of Mitochondrial Tethering by Mitofusin Complexes; Science;
Vol. 305; No. 5685; 858-862; 10.1126/science.1099793
- Chen, Hsiuchen and Chan, David C. (2004) Mitochondrial
Dynamics in Mammals; Current Topics in Developmental Biology; Vol.
59; 119-144; 10.1016/S0070-2153(04)59005-1
- Karbowski, Mariusz; Arnoult, Damien; et el. (2004) Quantitation
of mitochondrial dynamics by photolabeling of individual organelles
shows that mitochondrial fusion is blocked during the Bax activation
phase of apoptosis; Journal of Cell Biology; Vol. 164; No. 4;
493-499; PMCID PMC2172000; 10.1083/jcb.200309082
- Koshiba, Takumi and Chan, David C. (2003) The
Prefusogenic Intermediate of HIV-1 gp41 Contains Exposed C-peptide
Regions; Journal of Biological Chemistry; Vol. 278; No. 9;
7573-7579; 10.1074/jbc.M211154200
- Chen, Hsiuchen; Detmer, Scott A.; et el. (2003) Mitofusins
Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are
essential for embryonic development; Journal of Cell Biology; Vol.
160; No. 2; 189-200; PMCID PMC2172648; 10.1083/jcb.200211046
- Chan, David C.; Chutkowski, C. T.; et el. (1998) Evidence
that a prominent cavity in the coiled coil of HIV type 1 gp41 is an
attractive drug target; Proceedings of the National Academy of
Sciences of the United States of America; Vol. 95; No. 26; 15613-15617;
PMCID PMC28092; 10.1073/pnas.95.26.15613
- Malashkevich, Vladimir N.; Chan, David C.; et el. (1998) Crystal
structure of the simian immunodeficiency virus (SIV) gp41 core:
Conserved helical interactions underlie the broad inhibitory activity of
gp41 peptides; Proceedings of the National Academy of Sciences of
the United States of America; Vol. 95; No. 16; 9134-9139; PMCID
PMC21304
- Chan, David C. and Kim, Peter S. (1998) HIV
Entry and Its Inhibition; Cell; Vol. 93; No. 5; 681-684; 10.1016/S0092-8674(00)81430-0
- Chan, David C.; Fass, Deborah; et el. (1997) Core
Structure of gp41 from the HIV Envelope Glycoprotein; Cell; Vol. 89;
No. 2; 263-273; 10.1016/S0092-8674(00)80205-6
- Chan, David C.; Wynshaw-Boris, Anthony; et el. (1995) Formin
isoforms are differentially expressed in the mouse embryo and are
required for normal expression of fgf-4 and shh in the limb bud;
Development; Vol. 121; No. 10; 3151-3162
- Chan, David C.; Laufer, Ed; et el. (1995) Polydactylous
limbs in Strong’s Luxoid mice result from ectopic polarizing
activity; Development; Vol. 121; No. 7; 1971-1978