<h1>Zernicka-Goetz, Magdalena</h1>
<h2>Article from <a href="https://authors.library.caltech.edu">CaltechAUTHORS</a></h2>
<ul>
<li>Hadas, Ron and Rubinstein, Hernan, el al. (2024) <a href="https://authors.library.caltech.edu/records/wgy1x-2tf47">Temporal BMP4 effects on mouse embryonic and extraembryonic development</a>; Nature; Vol. 634; 652–661; <a href="https://doi.org/10.1038/s41586-024-07937-5">10.1038/s41586-024-07937-5</a></li>
<li>Zernicka-Goetz, Magdalena and Hyun, Insoo (2024) <a href="https://authors.library.caltech.edu/records/1pjnf-anz02">Embryo models need consistent ethical oversight</a>; Nature; Vol. 630; No. 8016; 305; <a href="https://doi.org/10.1038/d41586-024-01728-8">10.1038/d41586-024-01728-8</a></li>
<li>Zhu, Meng and Meglicki, Maciej, el al. (2024) <a href="https://authors.library.caltech.edu/records/x3gb1-p2s80">Tead4 and Tfap2c generate bipotency and a bistable switch in totipotent embryos to promote robust lineage diversification</a>; Nature Structural &amp; Molecular Biology; <a href="https://doi.org/10.1038/s41594-024-01311-9">10.1038/s41594-024-01311-9</a></li>
<li>Junyent, Sergi and Meglicki, Maciej, el al. (2024) <a href="https://authors.library.caltech.edu/records/wn4wr-xfb87">The first two blastomeres contribute unequally to the human embryo</a>; Cell; Vol. 187; No. 11; 2838-2854.e17; <a href="https://doi.org/10.1016/j.cell.2024.04.029">10.1016/j.cell.2024.04.029</a></li>
<li>Sato, Nanami and Rosa, Viviane S., el al. (2024) <a href="https://authors.library.caltech.edu/records/91vgr-kpw72">Basal delamination during mouse gastrulation primes pluripotent cells for differentiation</a>; Developmental Cell; Vol. 59; No. 10; 1252-1268.e13; <a href="https://doi.org/10.1016/j.devcel.2024.03.008">10.1016/j.devcel.2024.03.008</a></li>
<li>Weatherbee, Bailey A. T. and Weberling, Antonia, el al. (2024) <a href="https://authors.library.caltech.edu/records/nkste-7tj29">Distinct pathways drive anterior hypoblast specification in the implanting human embryo</a>; Nature Cell Biology; <a href="https://doi.org/10.1038/s41556-024-01367-1">10.1038/s41556-024-01367-1</a></li>
<li>Handford, Charlotte E and Junyent, Sergi, el al. (2024) <a href="https://authors.library.caltech.edu/records/fas7r-aa477">Topical section: embryonic models (2023) for Current Opinion in Genetics &amp; Development</a>; Current Opinion in Genetics &amp; Development; Vol. 84; 102134; <a href="https://doi.org/10.1016/j.gde.2023.102134">10.1016/j.gde.2023.102134</a></li>
<li>Zernicka-Goetz, Magdalena (2023) <a href="https://authors.library.caltech.edu/records/yxn76-3fk50">The evolution of embryo models</a>; Nature Methods; <a href="https://doi.org/10.1038/s41592-023-02077-6">10.1038/s41592-023-02077-6</a></li>
<li>Lau, Kasey Y. C. and Amadei, Gianluca, el al. (2023) <a href="https://authors.library.caltech.edu/records/xq10b-71b55">Assembly of complete mouse embryo models from embryonic and induced stem cell types in vitro</a>; Nature Protocols; Vol. 18; No. 12; 3662-3689; <a href="https://doi.org/10.1038/s41596-023-00891-y">10.1038/s41596-023-00891-y</a></li>
<li>Bao, Min and Cornwall-Scoones, Jake, el al. (2023) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20230602-251540000.11">Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension</a>; Nature Cell Biology; Vol. 24; No. 9; 1341-2349; PMCID PMC9481465; <a href="https://doi.org/10.1038/s41556-022-00984-y">10.1038/s41556-022-00984-y</a></li>
<li>De Jonghe, Joachim and Kaminski, Tomasz S., el al. (2023) <a href="https://authors.library.caltech.edu/records/8w05t-tbd96">spinDrop: a droplet microfluidic platform to maximise single-cell sequencing information content</a>; Nature Communications; Vol. 14; 4788; PMCID PMC10409775; <a href="https://doi.org/10.1038/s41467-023-40322-w">10.1038/s41467-023-40322-w</a></li>
<li>Weatherbee, Bailey A. T. and Gantner, Carlos W., el al. (2023) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20230628-295417000.9">A model of the post-implantation human embryo derived from pluripotent stem cells</a>; Nature; <a href="https://doi.org/10.1038/s41586-023-06368-y">10.1038/s41586-023-06368-y</a></li>
<li>Apostolou, Effie and Blau, Helen, el al. (2023) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20230725-857148000.45">Progress and challenges in stem cell biology</a>; Nature Cell Biology; Vol. 25; No. 2; 203-206; <a href="https://doi.org/10.1038/s41556-023-01087-y">10.1038/s41556-023-01087-y</a></li>
<li>Lau, Kasey Y. C. and Rubinstein, Hernan, el al. (2022) <a href="https://authors.library.caltech.edu/records/ykz2r-3p577">Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development</a>; Cell Stem Cell; Vol. 29; No. 10; 1445-1458.e8; PMCID PMC9648694; <a href="https://doi.org/10.1016/j.stem.2022.08.013">10.1016/j.stem.2022.08.013</a></li>
<li>Amadei, Gianluca and Handford, Charlotte E., el al. (2022) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20221010-454096500.25">Embryo model completes gastrulation to neurulation and organogenesis</a>; Nature; Vol. 610; No. 7930; 143-153; PMCID PMC9534772; <a href="https://doi.org/10.1038/s41586-022-05246-3">10.1038/s41586-022-05246-3</a></li>
<li>Lau, Kasey Y. C. and Rubinstein, Hernan, el al. (2022) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20221122-564647900.8">Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development</a>; Cell Stem Cell; Vol. 29; No. 10; 1445-1458.e8; PMCID PMC9648694; <a href="https://doi.org/10.1016/j.stem.2022.08.013">10.1016/j.stem.2022.08.013</a></li>
<li>Bao, Min and Cornwall-Scoones, Jake, el al. (2022) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20220909-232668000">Stem-cell-based human and mouse embryo models</a>; Current Opinion in Genetics and Development; Vol. 76; 101970; PMCID PMC10309046; <a href="https://doi.org/10.1016/j.gde.2022.101970">10.1016/j.gde.2022.101970</a></li>
<li>Bao, Min and Cornwall-Scoones, Jake, el al. (2022) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20220919-149101800">Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension</a>; Nature Cell Biology; Vol. 24; No. 9; 1341-1349; PMCID PMC9481465; <a href="https://doi.org/10.1038/s41556-022-00984-y">10.1038/s41556-022-00984-y</a></li>
<li>Liang, Xuan and Weberling, Antonia, el al. (2022) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20220826-428674800.766">E-cadherin mediates apical membrane initiation site localisation during de novo polarisation of epithelial cavities</a>; EMBO Journal; Art No. e111021; <a href="https://doi.org/10.15252/embj.2022111021">10.15252/embj.2022111021</a></li>
<li>Shen, Cheng and Lamba, Adiyant, el al. (2022) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20220215-496417800">Stain-free detection of embryo polarization using deep learning</a>; Scientific Reports; Vol. 12; Art. No. 2404; <a href="https://doi.org/10.1038/s41598-022-05990-6">10.1038/s41598-022-05990-6</a></li>
<li>Duethorn, Binyamin and Groll, Fabian, el al. (2022) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20220201-160162400">Lima1 mediates the pluripotency control of membrane dynamics and cellular metabolism</a>; Nature Communications; Vol. 13; Art. No. 610; PMCID PMC8807836; <a href="https://doi.org/10.1038/s41467-022-28139-5">10.1038/s41467-022-28139-5</a></li>
<li>Rawlings, Thomas M. and Makwana, Komal, el al. (2021) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20211124-161127351">Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids</a>; eLife; Vol. 10; Art. No. e69603; PMCID PMC8523170; <a href="https://doi.org/10.7554/elife.69603">10.7554/elife.69603</a></li>
<li>Zhu, Meng and Shahbazi, Marta, el al. (2021) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20200925-104734056">Human embryo polarization requires PLC signaling to mediate trophectoderm specification</a>; eLife; Vol. 10; Art. No. e65068; <a href="https://doi.org/10.7554/eLife.65068">10.7554/eLife.65068</a></li>
<li>Sozen, Berna and Jorgensen, Victoria, el al. (2021) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20210317-080317393">Reconstructing aspects of human embryogenesis with pluripotent stem cells</a>; Nature Communications; Vol. 12; Art. No. 5550; PMCID PMC8455697; <a href="https://doi.org/10.1038/s41467-021-25853-4">10.1038/s41467-021-25853-4</a></li>
<li>Mackinlay, Kirsty M. L. and Weatherbee, Bailey A. T., el al. (2021) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20210930-211337700">An in vitro stem cell model of human epiblast and yolk sac interaction</a>; eLife; Vol. 10; Art. No. e63930; PMCID PMC8370770; <a href="https://doi.org/10.7554/elife.63930">10.7554/elife.63930</a></li>
<li>Molè, Matteo A. and Coorens, Tim H. H., el al. (2021) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20210618-210040654">A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre</a>; Nature Communications; Vol. 12; Art. No. 3679; <a href="https://doi.org/10.1038/s41467-021-23758-w">10.1038/s41467-021-23758-w</a></li>
<li>Weatherbee, Bailey A. T. and Cui, Tongtong, el al. (2021) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20201217-133744400">Modeling human embryo development with embryonic and extra-embryonic stem cells</a>; Developmental Biology; Vol. 474; 91-99; PMCID PMC8232073; <a href="https://doi.org/10.1016/j.ydbio.2020.12.010">10.1016/j.ydbio.2020.12.010</a></li>
<li>Cornwall-Scoones, Jake and Zernicka-Goetz, Magdalena (2021) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20210322-130659658">Unifying synthetic embryology</a>; Developmental Biology; Vol. 474; 1-4; PMCID PMC8257322; <a href="https://doi.org/10.1016/j.ydbio.2021.03.007">10.1016/j.ydbio.2021.03.007</a></li>
<li>Sozen, Berna and Cornwall-Scoones, Jake, el al. (2021) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20201217-133744809">The dynamics of morphogenesis in stem cell-based embryology: Novel insights for symmetry breaking</a>; Developmental Biology; Vol. 474; 82-90; PMCID PMC8259461; <a href="https://doi.org/10.1016/j.ydbio.2020.12.005">10.1016/j.ydbio.2020.12.005</a></li>
<li>Guo, Jianying and Wang, Peizhe, el al. (2021) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20210504-094816688">Machine learning-assisted high-content analysis of pluripotent stem cell-derived embryos in vitro</a>; Stem Cell Reports; Vol. 16; No. 5; 1331-1346; PMCID PMC8185434; <a href="https://doi.org/10.1016/j.stemcr.2021.03.018">10.1016/j.stemcr.2021.03.018</a></li>
<li>Orietti, Lorenzo C. and Rosa, Viviane Souza, el al. (2021) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20201009-083350141">Embryo Size Regulates the Timing and Mechanism of Pluripotent Tissue Morphogenesis</a>; Stem Cell Reports; Vol. 16; No. 5; 1182-1196; PMCID PMC8185375; <a href="https://doi.org/10.1016/j.stemcr.2020.09.004">10.1016/j.stemcr.2020.09.004</a></li>
<li>Shi, Junchao and Zhang, Yunfang, el al. (2021) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20210211-165540246">PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications</a>; Nature Cell Biology; Vol. 23; No. 4; 424-436; <a href="https://doi.org/10.1038/s41556-021-00652-7">10.1038/s41556-021-00652-7</a></li>
<li>Molè, Matteo Amitaba and Weberling, Antonia, el al. (2021) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20210310-141520229">Integrin β1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition</a>; Cell Reports; Vol. 34; No. 10; Art. No. 108834; PMCID PMC7966855; <a href="https://doi.org/10.1016/j.celrep.2021.108834">10.1016/j.celrep.2021.108834</a></li>
<li>Amadei, Gianluca and Lau, Kasey Y. C., el al. (2021) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20210104-164232285">Inducible Stem-Cell-Derived Embryos Capture Mouse Morphogenetic Events In Vitro</a>; Developmental Cell; Vol. 56; No. 3; 366-382; PMCID PMC7883308; <a href="https://doi.org/10.1016/j.devcel.2020.12.004">10.1016/j.devcel.2020.12.004</a></li>
<li>Sozen, Berna and Demir, Necdet, el al. (2021) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20201117-110225184">BMP signalling is required for extra-embryonic ectoderm development during pre-to-post-implantation transition of the mouse embryo</a>; Developmental Biology; Vol. 470; 84-94; PMCID PMC8219371; <a href="https://doi.org/10.1016/j.ydbio.2020.11.005">10.1016/j.ydbio.2020.11.005</a></li>
<li>Weberling, Antonia and Zernicka-Goetz, Magdalena (2021) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20210119-143307098">Trophectoderm mechanics direct epiblast shape upon embryo implantation</a>; Cell Reports; Vol. 34; No. 3; Art. No. 108655; PMCID PMC7816124; <a href="https://doi.org/10.1016/j.celrep.2020.108655">10.1016/j.celrep.2020.108655</a></li>
<li>Zhu, Meng and Cornwall-Scoones, Jake, el al. (2020) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20200212-084819179">Developmental clock and mechanism of de novo polarization of the mouse embryo</a>; Science; Vol. 370; No. 6522; Art. No. eabd2703; PMCID PMC8210885; <a href="https://doi.org/10.1126/science.abd2703">10.1126/science.abd2703</a></li>
<li>Zhu, Meng and Zernicka-Goetz, Magdalena (2020) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20201210-160239379">Principles of Self-Organization of the Mammalian Embryo</a>; Cell; Vol. 183; No. 6; 1467-1478; PMCID PMC8212876; <a href="https://doi.org/10.1016/j.cell.2020.11.003">10.1016/j.cell.2020.11.003</a></li>
<li>Lynch, Cian J. and Bernad, Raquel, el al. (2020) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20201012-163632801">Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases</a>; Nature Cell Biology; Vol. 22; No. 10; 1223-1238; <a href="https://doi.org/10.1038/s41556-020-0573-1">10.1038/s41556-020-0573-1</a></li>
<li>Cornwall-Scoones, Jake and Zernicka-Goetz, Magdalena (2020) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20201009-152128912">Starting life in space</a>; National Science Review; Vol. 7; No. 9; 1447-1448; <a href="https://doi.org/10.1093/nsr/nwaa102">10.1093/nsr/nwaa102</a></li>
<li>Shahbazi, Marta N. and Wang, Tianren, el al. (2020) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20200811-114715166">Developmental potential of aneuploid human embryos cultured beyond implantation</a>; Nature Communications; Vol. 11; Art. No. 3987; PMCID PMC7418029; <a href="https://doi.org/10.1038/s41467-020-17764-7">10.1038/s41467-020-17764-7</a></li>
<li>Weatherbee, Bailey A. T. and Glover, David M., el al. (2020) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20200805-090719433">Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester</a>; Open Biology; Vol. 10; No. 8; 200162; PMCID PMC7479935; <a href="https://doi.org/10.1098/rsob.200162">10.1098/rsob.200162</a></li>
<li>Kyprianou, Christos and Christodoulou, Neophytos, el al. (2020) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20200121-134023730">Basement membrane remodelling regulates mouse embryogenesis</a>; Nature; Vol. 582; No. 7811; 253-258; PMCID PMC7308173; <a href="https://doi.org/10.1038/s41586-020-2264-2">10.1038/s41586-020-2264-2</a></li>
<li>Singla, Shruti and Iwamoto-Stohl, Lisa K., el al. (2020) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20200611-161658303">Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism</a>; Nature Communications; Vol. 11; Art. No. 2958; PMCID PMC7290028; <a href="https://doi.org/10.1038/s41467-020-16796-3">10.1038/s41467-020-16796-3</a></li>
<li>Zhu, Meng and Zernicka-Goetz, Magdalena (2020) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20200406-124658130">Living a Sweet Life: Glucose Instructs Cell Fate in the Mouse Embryo</a>; Developmental Cell; Vol. 53; No. 1; 1-2; <a href="https://doi.org/10.1016/j.devcel.2020.03.012">10.1016/j.devcel.2020.03.012</a></li>
<li>Zhu, Meng and Zernicka-Goetz, Magdalena (2020) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20200409-115737960">Building an apical domain in the early mouse embryo: Lessons, challenges and perspectives</a>; Current Opinion in Cell Biology; Vol. 62; 144-149; <a href="https://doi.org/10.1016/j.ceb.2019.11.005">10.1016/j.ceb.2019.11.005</a></li>
<li>Sozen, Berna and Cox, Andy L., el al. (2019) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20191216-145145496">Self-Organization of Mouse Stem Cells into an Extended Potential Blastoid</a>; Developmental Cell; Vol. 51; No. 6; 698-712; PMCID PMC10291877; <a href="https://doi.org/10.1016/j.devcel.2019.11.014">10.1016/j.devcel.2019.11.014</a></li>
<li>Aloia, Luigi and McKie, Mikel Alexander, el al. (2019) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20191111-124015897">Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration</a>; Nature Cell Biology; Vol. 21; No. 11; 1321-1333; PMCID PMC6940196; <a href="https://doi.org/10.1038/s41556-019-0402-6">10.1038/s41556-019-0402-6</a></li>
<li>Anikeeva, Polina and Cissé, Ibrahim I., el al. (2019) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20191017-144439188">Voices in methods development</a>; Nature Methods; Vol. 16; No. 10; 945-951; PMCID PMC7075469; <a href="https://doi.org/10.1038/s41592-019-0585-6">10.1038/s41592-019-0585-6</a></li>
<li>Christodoulou, Neophytos and Weberling, Antonia, el al. (2019) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20200409-115738046">Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation</a>; Nature Communications; Vol. 10; Art. No. 3557; PMCID PMC6686005; <a href="https://doi.org/10.1038/s41467-019-11482-5">10.1038/s41467-019-11482-5</a></li>
<li>Antonica, Francesco and Orietti, Lorenzo Carlo, el al. (2019) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20190408-111045626">Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration</a>; Developmental Biology; Vol. 450; No. 2; 132-140; PMCID PMC6553843; <a href="https://doi.org/10.1016/j.ydbio.2019.03.016">10.1016/j.ydbio.2019.03.016</a></li>
<li>Shahbazi, Marta N. and Siggia, Eric D., el al. (2019) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20200409-115738157">Self-organization of stem cells into embryos: A window on early mammalian development</a>; Science; Vol. 364; No. 6444; 948-951; <a href="https://doi.org/10.1126/science.aax0164">10.1126/science.aax0164</a></li>
<li>Rivron, Nicolas and Pera, Martin, el al. (2018) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20190408-111045932">Debate ethics of embryo models from stem cells</a>; Nature; Vol. 564; No. 7735; 183-185; <a href="https://doi.org/10.1038/d41586-018-07663-9">10.1038/d41586-018-07663-9</a></li>
<li>Hupalowska, Anna and Jedrusik, Agnieszka, el al. (2018) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20190408-111045813">CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development</a>; Cell; Vol. 175; No. 7; 1902-1916.e13; PMCID PMC6292842; <a href="https://doi.org/10.1016/j.cell.2018.11.027">10.1016/j.cell.2018.11.027</a></li>
<li>Christodoulou, Neophytos and Kyprianou, Christos, el al. (2018) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20190408-111046061">Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation</a>; Nature Cell Biology; Vol. 20; No. 11; 1278-1289; <a href="https://doi.org/10.1038/s41556-018-0211-3">10.1038/s41556-018-0211-3</a></li>
<li>Sozen, Berna and Amadei, Gianluca, el al. (2018) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20190408-111046182">Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures</a>; Nature Cell Biology; Vol. 20; No. 8; 979-989; <a href="https://doi.org/10.1038/s41556-018-0147-7">10.1038/s41556-018-0147-7</a></li>
<li>Shahbazi, Marta N. and Zernicka-Goetz, Magdalena (2018) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20190405-170314164">Deconstructing and reconstructing the mouse and human early embryo</a>; Nature Cell Biology; Vol. 20; No. 8; 878-887; <a href="https://doi.org/10.1038/s41556-018-0144-x">10.1038/s41556-018-0144-x</a></li>
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