[ { "id": "authors:3n4ah-x3781", "collection": "authors", "collection_id": "3n4ah-x3781", "cite_using_url": "https://authors.library.caltech.edu/records/3n4ah-x3781", "type": "article", "title": "Geometry-dependent defect merging induces bifurcated dynamics in active networks", "author": [ { "family_name": "Yang", "given_name": "Fan", "orcid": "0000-0002-2248-2026", "clpid": "Yang-Fan" }, { "family_name": "Liu", "given_name": "Shichen", "clpid": "Liu-Shichen" }, { "family_name": "Wang", "given_name": "Hao", "orcid": "0000-0001-9976-9247", "clpid": "Wang-Hao" }, { "family_name": "Lee", "given_name": "Heun Jin", "orcid": "0009-0002-4615-9271", "clpid": "Lee-Heun-Jin" }, { "family_name": "Phillips", "given_name": "Rob", "orcid": "0000-0003-3082-2809", "clpid": "Phillips-R" }, { "family_name": "Thomson", "given_name": "Matt", "orcid": "0000-0003-1021-1234", "clpid": "Thomson-M-W" } ], "abstract": "Cytoskeletal networks can repair defects to maintain structural integrity. However, the mechanisms and dynamics of defect merging remain poorly understood. Here, we report a geometry-tunable merging mechanism in microtubule-motor networks initiated by active crosslinking. We directly generate defects using a light-controlled microtubule-motor system in O-shaped and V-shaped networks, and observe that the defects can self-close. Combining theory and experiment, we find that the V-shaped networks must overcome internal elastic resistance in order to zip up cracks, giving rise to a bifurcation of dynamics dependent on the initial opening angle of the crack: the crack merges below a critical angle and opens up at larger angles. Simulation of a continuum model reproduces the bifurcation dynamics, revealing the importance of overlapping boundary layers where free motors and microtubules can actively crosslink and thereby merge the defects. We also formulate a simple elastic-rod model that can qualitatively predict the critical angle, which is tunable by the network geometry.", "doi": "10.1103/m8cb-gf1q", "issn": "2643-1564", "publisher": "American Physical Society", "publication": "Physical Review Research", "publication_date": "2025-10-03", "series_number": "4", "volume": "7", "issue": "4", "pages": "L042006" }, { "id": "authors:67et8-v9v55", "collection": "authors", "collection_id": "67et8-v9v55", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20220114-264688000", "type": "article", "title": "Revisiting KELT-19Ab, WASP-156b, and WASP-121b in the TESS Era", "author": [ { "family_name": "Yang", "given_name": "Fan", "orcid": "0000-0002-6039-8212", "clpid": "Yang-Fan" }, { "family_name": "Chary", "given_name": "Ranga-Ram", "orcid": "0000-0001-7583-0621", "clpid": "Chary-Ranga-Ram" }, { "family_name": "Liu", "given_name": "Ji-Feng", "orcid": "0000-0002-2874-2706", "clpid": "Liu-Ji-Feng" } ], "abstract": "We present a re-analysis of transit depths of KELT-19Ab, WASP-156b, and WASP-121b, including data from the Transiting Exoplanet Survey Satellite (TESS). The large \u223c21\u2033 TESS pixels and point-spread function result in significant contamination of the stellar flux by nearby objects. We use Gaia data to fit for and remove this contribution, providing general-purpose software for this correction. We find all three sources have a larger inclination, compared to earlier work. For WASP-121b, we find significantly smaller values (13.\u00b05) of the inclination when using the 30 minute cadence data compared to the 2 minute cadence data. Using simulations, we demonstrate that the radius ratio of exoplanet to star (R_p/R_*) is biased small relative to data taken with a larger sampling interval although oversampling corrections mitigate the bias. This is particularly important for deriving subpercent transit differences between bands. We find the radius ratio of exoplanet to star (R_p/R_*) in the TESS band is 7.5\u03c3 smaller than previous work for KELT-19Ab, but consistent to within \u223c2\u03c3 for WASP-156b and WASP-121b. The difference could be due to specific choices in the analysis, not necessarily due to the presence of atmospheric features. The result for KELT-19Ab possibly favors a haze-dominated atmosphere. We do not find evidence for the \u223c0.95 \u03bcm water feature contaminating transit depths in the TESS band for these stars but show that with photometric precision of 500 ppm and with a sampling of about 200 observations across the entire transit, this feature could be detectable in a more narrow z-band.", "doi": "10.3847/1538-3881/ac3b4e", "issn": "0004-6256", "publisher": "American Astronomical Society", "publication": "Astronomical Journal", "publication_date": "2022-02", "series_number": "2", "volume": "163", "issue": "2", "pages": "Art. No. 42" }, { "id": "authors:ks7h3-tf644", "collection": "authors", "collection_id": "ks7h3-tf644", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20201110-143708446", "type": "article", "title": "Persistent fluid flows defined by active matter boundaries", "author": [ { "family_name": "Qu", "given_name": "Zijie", "orcid": "0000-0003-1500-3207", "clpid": "Qu-Zijie" }, { "family_name": "Schildknecht", "given_name": "Dominik", "orcid": "0000-0002-0678-0904", "clpid": "Schildknecht-Dominik" }, { "family_name": "Shadkhoo", "given_name": "Shahriar", "orcid": "0000-0003-3582-0634", "clpid": "Shadkhoo-Shahriar" }, { "family_name": "Amaya", "given_name": "Enrique", "clpid": "Amaya-Enrique" }, { "family_name": "Jiang", "given_name": "Jialong", "clpid": "Jiang-Jialong" }, { "family_name": "Lee", "given_name": "Heun Jin", "clpid": "Lee-Heun-Jin" }, { "family_name": "Larios", "given_name": "David", "clpid": "Larios-David" }, { "family_name": "Yang", "given_name": "Fan", "orcid": "0000-0002-2248-2026", "clpid": "Yang-Fan" }, { "family_name": "Phillips", "given_name": "Rob", "orcid": "0000-0003-3082-2809", "clpid": "Phillips-R" }, { "family_name": "Thomson", "given_name": "Matt", "orcid": "0000-0003-1021-1234", "clpid": "Thomson-M-W" } ], "abstract": "Biological systems control ambient fluids through the self-organization of active protein structures, including flagella, cilia, and cytoskeletal networks. Self-organization of protein components enables the control and modulation of fluid flow fields on micron scales, however, the physical principles underlying the organization and control of active-matter-driven fluid flows are poorly understood. Here, we use an optically-controlled active-matter system composed of microtubule filaments and light-switchable kinesin motor proteins to analyze the emergence of persistent flow fields. Using light, we form contractile microtubule networks of varying size and shape, and demonstrate that the geometry of microtubule flux at the corners of contracting microtubule networks predicts the architecture of fluid flow fields across network geometries through a simple point force model. Our work provides a foundation for programming microscopic fluid flows with controllable active matter and could enable the engineering of versatile and dynamic microfluidic devices.", "doi": "10.1038/s42005-021-00703-3", "issn": "2399-3650", "publisher": "Nature Publishing Group", "publication": "Communications Physics", "publication_date": "2021-08-27", "volume": "4", "pages": "Art. No. 198" }, { "id": "authors:vgdp6-yd675", "collection": "authors", "collection_id": "vgdp6-yd675", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20210604-111534656", "type": "article", "title": "An Empirical Bayesian Approach to Limb Darkening in Modeling WASP-121b Transit Light Curves", "author": [ { "family_name": "Yang", "given_name": "Fan", "orcid": "0000-0002-6039-8212", "clpid": "Yang-Fan" }, { "family_name": "Long", "given_name": "Richard J.", "orcid": "0000-0002-8559-0067", "clpid": "Long-Richard-J" }, { "family_name": "Liu", "given_name": "Ji-feng", "clpid": "Liu-Ji-Feng" }, { "family_name": "Shan", "given_name": "Su-su", "orcid": "0000-0002-5744-2016", "clpid": "Shan-Su-Su" }, { "family_name": "Guo", "given_name": "Rui", "orcid": "0000-0001-5536-0669", "clpid": "Guo-Rui" }, { "family_name": "Zhang", "given_name": "Bo", "orcid": "0000-0002-6434-7201", "clpid": "Zhang-Bo" }, { "family_name": "Yi", "given_name": "Tuan", "orcid": "0000-0002-5839-6744", "clpid": "Yi-Tuan" }, { "family_name": "Zheng", "given_name": "Ling-Lin", "clpid": "Zheng-Ling-Lin" }, { "family_name": "Zhao", "given_name": "Zhi-Chao", "clpid": "Zhao-Zhi-Chao" } ], "abstract": "We present a novel, iterative method using an empirical Bayesian approach for modeling the limb-darkened WASP-121b transit from the TESS light curve. Our method is motivated by the need to improve R_p/R_* estimates for exoplanet atmosphere modeling and is particularly effective with the limb-darkening (LD) quadratic law requiring no prior central value from stellar atmospheric models. With the nonlinear LD law, the method has all the advantages of not needing atmospheric models but does not converge. The iterative method gives a different R_p/R_* for WASP-121b at a significance level of 1\u03c3 when compared with existing noniterative methods. To assess the origins and implications of this difference, we generate and analyze light curves with known values of the LD coefficients (LDCs). We find that noniterative modeling with LDC priors from stellar atmospheric models results in an inconsistent R_p/R_* at a 1.5\u03c3 level when the known LDC values are the same as those previously found when modeling real data by the iterative method. In contrast, the LDC values from the iterative modeling yield the correct value of R_p/R_* to within 0.25\u03c3. For more general cases with different known inputs, Monte Carlo simulations show that the iterative method obtains unbiased LDCs and correct R_p/R_* to within a significance level of 0.3\u03c3. Biased LDC priors can cause biased LDC posteriors and lead to bias in the R_p/R_* of up to 0.82%, 2.5\u03c3 for the quadratic law and 0.32%, 1.0\u03c3 for the nonlinear law. Our improvement in R_p/R_* estimation is important when analyzing exoplanet atmospheres.", "doi": "10.3847/1538-3881/abf92f", "issn": "0004-6256", "publisher": "American Astronomical Society", "publication": "Astronomical Journal", "publication_date": "2021-06", "series_number": "6", "volume": "161", "issue": "6", "pages": "Art. No. 294" }, { "id": "authors:swmhf-anr14", "collection": "authors", "collection_id": "swmhf-anr14", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20200807-090348710", "type": "article", "title": "A Catalog of Short Period Spectroscopic and Eclipsing Binaries Identified from the LAMOST and PTF Surveys", "author": [ { "family_name": "Yang", "given_name": "Fan", "orcid": "0000-0002-6039-8212", "clpid": "Yang-Fan" }, { "family_name": "Long", "given_name": "Richard J.", "orcid": "0000-0002-8559-0067", "clpid": "Long-R-J" }, { "family_name": "Shan", "given_name": "Su-Su", "orcid": "0000-0002-5744-2016", "clpid": "Shan-Su-Su" }, { "family_name": "Zhang", "given_name": "Bo", "orcid": "0000-0002-6434-7201", "clpid": "Zhang-Bo" }, { "family_name": "Guo", "given_name": "Rui", "clpid": "Guo-Rui" }, { "family_name": "Bai", "given_name": "Yu", "orcid": "0000-0002-4740-3857", "clpid": "Bai-Yu" }, { "family_name": "Bai", "given_name": "Zhongrui", "orcid": "0000-0003-3884-5693", "clpid": "Bai-Zhongrui" }, { "family_name": "Cui", "given_name": "Kai-Ming", "clpid": "Cui-Kai-Ming" }, { "family_name": "Wang", "given_name": "Song", "orcid": "0000-0003-3116-5038", "clpid": "Wang-Song" }, { "family_name": "Liu", "given_name": "Ji-Feng", "clpid": "Liu-Ji-Feng" } ], "abstract": "Binaries play key roles in determining stellar parameters and exploring stellar evolution models. We build a catalog of 88 eclipsing binaries with spectroscopic information, taking advantage of observations from both the Large Sky Area Multi-Object fiber Spectroscopic Telescope and the Palomar Transient Factory surveys. A software pipeline is constructed to identify binary candidates by examining their light curves. The orbital periods of binaries are derived from the Lomb\u2013Scargle method. The key distinguishing features of eclipsing binaries are recognized by a new filter, Flat Test. We classify the eclipsing binaries by applying a Fourier analysis on the light curves. Among all the binary stars, 13 binaries are identified as eclipsing binaries for the first time. The catalog contains the following information: the position, primary eclipsing magnitude and time, eclipsing depth, the number of photometry and radial velocity observations, largest radial velocity difference, binary type, the effective temperature of the observable star T eff, and surface gravity of the observable star log g. The false-positive probability is calculated by using both a Monte Carlo simulation and real data from the Sloan Digital Sky Survey Stripe 82 Standard Catalog. The binaries in the catalog are mostly with a period of less than one day. The period distribution shows a 0.22 day cutoff, which is consistent with the low probability of an eclipsing binary rotating with such a period.", "doi": "10.3847/1538-4365/ab9b77", "issn": "1538-4365", "publisher": "American Astronomical Society", "publication": "Astrophysical Journal Supplement Series", "publication_date": "2020-08", "series_number": "2", "volume": "249", "issue": "2", "pages": "Art. No. 31" }, { "id": "authors:5y8dd-5x714", "collection": "authors", "collection_id": "5y8dd-5x714", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20200713-130247847", "type": "article", "title": "Evaluation of sputtered nickel oxide, cobalt oxide and nickel\u2013cobalt oxide on n-type silicon photoanodes for solar-driven O\u2082(g) evolution from water", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Zhou", "given_name": "Xinghao", "orcid": "0000-0001-9229-7670", "clpid": "Zhou-Xinghao" }, { "family_name": "Plymale", "given_name": "Noah T.", "orcid": "0000-0003-2564-8009", "clpid": "Plymale-N-T" }, { "family_name": "Sun", "given_name": "Ke", "orcid": "0000-0001-8209-364X", "clpid": "Sun-Ke" }, { "family_name": "Lewis", "given_name": "Nathan S.", "orcid": "0000-0001-5245-0538", "clpid": "Lewis-N-S" } ], "abstract": "Thin films of nickel oxide (NiO_x), cobalt oxide (CoO_x) and nickel\u2013cobalt oxide (NiCoO_x) were sputtered onto n-Si(111) surfaces to produce a series of integrated, protected Si photoanodes that did not require deposition of a separate heterogeneous electrocatalyst for water oxidation. The p-type transparent conductive oxides (p-TCOs) acted as multi-functional transparent, antireflective, electrically conductive, chemically stable coatings that also were active electrocatalysts for the oxidation of water to O\u2082(g). Relative to the formal potential for water oxidation to O\u2082, E^(o\u2032)(O\u2082/H\u2082O), under simulated Air Mass (AM)1.5 illumination the p-TCO-coated n-Si(111) photoanodes produced mutually similar open-circuit potentials of \u2212270 \u00b1 20 mV, but different photocurrent densities at E^(o\u2032)(O\u2082/H\u2082O), of 28 \u00b1 0.3 mA cm\u207b\u00b2 for NiO_x, 18 \u00b1 0.3 mA cm\u207b\u00b2 for CoO_x and 24 \u00b1 0.5 mA cm\u207b\u00b2 for NiCoO_x. The p-TCOs all provided protection from oxide growth for extended time periods, and produced stable photocurrent densities from n-Si in 1.0 M KOH(aq) (ACS grade) under potential control at E^(o\u2032)(O\u2082/H\u2082O) for >400 h of continuous operation under 100 mW cm\u22122 of simulated AM1.5 illumination.", "doi": "10.1039/d0ta03725g", "issn": "2050-7488", "publisher": "Royal Society of Chemistry", "publication": "Journal of Materials Chemistry A", "publication_date": "2020-07-28", "series_number": "28", "volume": "8", "issue": "28", "pages": "13955-13963" }, { "id": "authors:9h9a3-s5a08", "collection": "authors", "collection_id": "9h9a3-s5a08", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20200908-140219805", "type": "article", "title": "Galaxy optical variability of Virgo cluster: new tracer for environmental influences on galaxies", "author": [ { "family_name": "Yang", "given_name": "Fan", "orcid": "0000-0002-6039-8212", "clpid": "Yang-Fan" }, { "family_name": "Long", "given_name": "Richard J.", "orcid": "0000-0002-8559-0067", "clpid": "Long-R-J" }, { "family_name": "Shan", "given_name": "Su-Su", "clpid": "Shan-Su-Su" }, { "family_name": "Ge", "given_name": "Jun-Qiang", "clpid": "Ge-Jun-Qiang" }, { "family_name": "Guo", "given_name": "Rui", "clpid": "Guo-Rui" }, { "family_name": "Zhang", "given_name": "Bo", "clpid": "Zhang-Bo" }, { "family_name": "Gao", "given_name": "Jing-Hua", "clpid": "Gao-Jing-Hua" }, { "family_name": "Ji", "given_name": "Xiang", "clpid": "Ji-Xiang" }, { "family_name": "Liu", "given_name": "Ji-Feng", "clpid": "Liu-Ji-Feng" } ], "abstract": "We investigate the relationship between the optical variability of galaxies and their distances from the centre of the Virgo cluster using Palomar Transient Factory data. We define the ratio between the standard deviation of the galaxy brightness and the mean value of the standard deviation as a measure of a galaxy's optical variability. A sample of 814 Virgo galaxies with 230\u2009263 observations shows a monotonically decreasing trend of optical variability with increasing clustercentric distance. The variability level inside the cluster is 3.2\u03c3 higher than the level outside. We fit the variability with a linear function and find that the data reject a distance-independent model. We examine 217 background galaxies for comparison and find no significant trend in galaxy variability. We assess the relation with Monte Carlo simulation by rebuilding the brightness of each galaxy. The simulation shows a monotonically decreasing relation for member galaxy variability and a distance-independent relation for background galaxies. Our result is consistent with the theory that the cold gas flowing inwards the cluster centre fuels AGN activity. This work is a new implementation of the method using optical variability to investigate the relation between galaxies evolution and their environment.", "doi": "10.1093/mnrasl/slaa083", "issn": "1745-3925", "publisher": "Royal Astronomical Society", "publication": "Monthly Notices of the Royal Astronomical Society: Letters", "publication_date": "2020-07", "series_number": "1", "volume": "496", "issue": "1", "pages": "L59-L63" }, { "id": "authors:5fyp9-08m63", "collection": "authors", "collection_id": "5fyp9-08m63", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20200423-144256885", "type": "article", "title": "Neutron-Induced Radiation Damage in LYSO, BaF\u2082 and PWO Crystals", "author": [ { "family_name": "Hu", "given_name": "Chen", "orcid": "0000-0002-3285-4831", "clpid": "Hu-Chen" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" }, { "family_name": "Kapustinsky", "given_name": "Jon", "clpid": "Kapustinsky-J-S" }, { "family_name": "Mocko", "given_name": "Michael", "clpid": "Mocko-M" }, { "family_name": "Nelson", "given_name": "Ron", "clpid": "Nelson-R-O" }, { "family_name": "Wang", "given_name": "Zhehui", "orcid": "0000-0001-7826-4063", "clpid": "Wang-Zhehui" } ], "abstract": "One crucial issue for the application of scintillation crystals in future high-energy physics experiments is radiation damage in a severe radiation environment, such as the high luminosity large hadron collider. While radiation damage induced by ionization dose in inorganic scintillators is well understood, investigations are ongoing to understand radiation damage induced by hadrons, including both charged hadrons and neutrons. Aiming at understanding neutron-induced radiation damage in fast inorganic scintillators, lutetium yttrium oxyorthosilicate (LYSO)/lutetium fine silicate (LFS), BaF\u2082, and PWO crystals were irradiated at Los Alamos Neutron Science Center by a combination of particles, including neutrons, protons, and \u03b3-rays. The results indicate that LYSO/LFS and BaF\u2082 crystal plates are radiation hard up to a 1-MeV equivalent neutrons fluence of 9\u00d710\u00b9\u2075 equivalent neutron (n_(eq))/cm\u00b2, but not PWO, and the neutron-induced radiation damage in LYSO crystals is a factor of ten less than protons.", "doi": "10.1109/tns.2020.2989116", "issn": "0018-9499", "publisher": "IEEE", "publication": "IEEE Transactions on Nuclear Science", "publication_date": "2020-06", "series_number": "6", "volume": "67", "issue": "6", "pages": "1086-1092" }, { "id": "authors:r97sa-3k925", "collection": "authors", "collection_id": "r97sa-3k925", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20181218-085412963", "type": "article", "title": "LuAG ceramic scintillators for future HEP experiments", "author": [ { "family_name": "Hu", "given_name": "Chen", "orcid": "0000-0002-3285-4831", "clpid": "Hu-Chen" }, { "family_name": "Li", "given_name": "Jiang", "clpid": "Li-Jiang" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Jiang", "given_name": "Benxue", "clpid": "Jiang-Benxue" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" } ], "abstract": "Because of its bright and fast scintillation cerium-doped Lu\u2083Al\u2085O\u2081\u2082 (LuAG:Ce) crystals have attracted an interest in the high energy physics community. Compared to inorganic crystals, fabrication of ceramic scintillators features with a lower temperature and a more effective use of raw materials, thus promising cost-effective inorganic scintillators. Our investigations revealed excellent radiation hardness of LuAG:Ce ceramics in both transmittance and light output against an ionization dose up to 200 Mrad and a proton fluence up to 3\u00d710\u00b9\u2074 p/cm\u00b2. We also investigated light output and decay kinetics for LuAG:Ce ceramics with different Ce doping levels and various co-dopings. The results show increased light output and slow scintillation component when the Ce doping level increases. Ca\u00b2\u207a co-doping is found effective in suppressing slow scintillation component in LuAG:Ce ceramics. We also discuss the status of LuAG ceramic scintillators and future development plan.", "doi": "10.1016/j.nima.2018.12.038", "issn": "0168-9002", "publisher": "Elsevier", "publication": "Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment", "publication_date": "2020-02-21", "volume": "954", "pages": "Art. No. 161723" }, { "id": "authors:qfdek-c1y34", "collection": "authors", "collection_id": "qfdek-c1y34", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20181130-095502456", "type": "article", "title": "Alkali-free Ce-doped and co-doped fluorophosphate glasses for future HEP experiments", "author": [ { "family_name": "Hu", "given_name": "Chen", "orcid": "0000-0002-3285-4831", "clpid": "Hu-Chen" }, { "family_name": "Margaryan", "given_name": "Alfred", "clpid": "Margaryan-Alfred" }, { "family_name": "Margaryan", "given_name": "Ashot", "clpid": "Margaryan-Ashot" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" } ], "abstract": "We report status of alkali-free cerium-doped and co-doped fluorophosphate glasses as a potential inorganic scintillator for future high energy physics experiments. Optical and scintillation properties, such as emission, transmittance, light output, decay time and their degradation after \u03b3-ray irradiations, are measured for glass samples produced at AFO Research Inc. Further developments are needed for this potential cost-effective glass scintillator to be used for the HHCAL detector concept.", "doi": "10.1016/j.nima.2018.11.124", "issn": "0168-9002", "publisher": "Elsevier", "publication": "Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment", "publication_date": "2020-02-21", "volume": "954", "pages": "Art. No. 161665" }, { "id": "authors:rs2g8-tch43", "collection": "authors", "collection_id": "rs2g8-tch43", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20191011-115115754", "type": "article", "title": "Searching for Black Hole Candidates by LAMOST and ASAS-SN", "author": [ { "family_name": "Zheng", "given_name": "Ling-Lin", "clpid": "Zheng-Ling-Lin" }, { "family_name": "Gu", "given_name": "Wei-Min", "orcid": "0000-0003-3137-1851", "clpid": "Gu-Wei-Min" }, { "family_name": "Yi", "given_name": "Tuan", "clpid": "Yi-Tuan" }, { "family_name": "Fu", "given_name": "Jin-Bo", "clpid": "Fu-Jin-Bo" }, { "family_name": "Mu", "given_name": "Hui-Jun", "orcid": "0000-0001-6589-2220", "clpid": "Mu-Hui-Jun" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Wang", "given_name": "Song", "orcid": "0000-0003-3116-5038", "clpid": "Wang-Song" }, { "family_name": "Bai", "given_name": "Zhong-Rui", "clpid": "Bai-Zhong-Rui" }, { "family_name": "Sou", "given_name": "Hao", "clpid": "Sou-Hao" }, { "family_name": "Bai", "given_name": "Yu", "orcid": "0000-0002-4740-3857", "clpid": "Bai-Yu" }, { "family_name": "Dong", "given_name": "Yi-Ze", "clpid": "Dong-Yi-Ze" }, { "family_name": "Zhang", "given_name": "Hao-Tong", "clpid": "Zhang-Hao-Tong" }, { "family_name": "Lei", "given_name": "Ya-Juan", "clpid": "Lei-Ya-Juan" }, { "family_name": "Wang", "given_name": "Junfeng", "orcid": "0000-0003-4874-0369", "clpid": "Wang-Junfeng" }, { "family_name": "Wu", "given_name": "Jianfeng", "clpid": "Wu-Jianfeng" }, { "family_name": "Liu", "given_name": "Jifeng", "clpid": "Liu-Jifeng" } ], "abstract": "Most dynamically confirmed stellar-mass black holes (BHs) and their candidates were originally selected from X-ray outbursts. In the present work, we search for BH candidates in the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) survey using the spectra along with photometry from the All Sky Automated Survey for SuperNovae (ASAS-SN), where the orbital period of the binary may be revealed by the periodic light curve, such as the ellipsoidal modulation type. Our sample consists of nine binaries, where each source contains a giant star with large radial velocity variation (\u0394V_R \u2273 70 km s^(-1)) and periods known from light curves. We focus on the nine sources with long periods (T_(ph) > 5 days) and evaluate the mass M_2 of the optically invisible companion. Since the observed \u0394V_R from only a few repeating spectroscopic observations is a lower limit of the real amplitude, the real mass M_2 can be significantly higher than the current evaluation. It is likely an efficient method to place constraints on M 2 by combining \u0394V_R from LAMOST and T_(ph) from ASAS-SN, particularly by the ongoing LAMOST Medium Resolution Survey.", "doi": "10.3847/1538-3881/ab449f", "issn": "1538-3881", "publisher": "American Astronomical Society", "publication": "Astronomical Journal", "publication_date": "2019-11", "series_number": "5", "volume": "158", "issue": "5", "pages": "Art. No. 179" }, { "id": "authors:a7xms-kgy75", "collection": "authors", "collection_id": "a7xms-kgy75", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20181207-083715675", "type": "article", "title": "La and La/Ce Doped BaF_2 Crystals for Future HEP Experiments at the Energy and Intensity Frontiers Part I", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Chen", "given_name": "Junfeng", "orcid": "0000-0003-3863-3324", "clpid": "Chen-Junfeng" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Hu", "given_name": "Chen", "orcid": "0000-0002-3285-4831", "clpid": "Hu-Chen" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" } ], "abstract": "Because of its fast scintillation component with subnanosecond decay time, BaF_2 crystals are considered as a candidate for ultrafast crystal calorimeters for future high energy physics experiments at the energy and intensity frontiers. Undoped BaF_2 , however, has a slow scintillation component with 600 ns decay time, which causes pile-up. In the part I of this paper, we report investigations on La doping in BaF_2 crystals to suppress the slow component. While typical fast/slow (F/S) ratio observed in undoped BaF_2 is 1/5, La-doped BaF_2 crystals were found to improve this ratio to about 1/1. The overall F/S ratio, however, is considered not sufficient for pile-up suppression.", "doi": "10.1109/tns.2018.2884978", "issn": "0018-9499", "publisher": "IEEE", "publication": "IEEE Transactions on Nuclear Science", "publication_date": "2019-01", "series_number": "1", "volume": "66", "issue": "1", "pages": "506-511" }, { "id": "authors:jkqp5-nf771", "collection": "authors", "collection_id": "jkqp5-nf771", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20190801-130418588", "type": "article", "title": "Neutron-Induced Radiation Damage in BaF_2, LYSO/LFS and PWO Crystals", "author": [ { "family_name": "Hu", "given_name": "Chen", "orcid": "0000-0002-3285-4831", "clpid": "Hu-Chen" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" }, { "family_name": "Kapustinsky", "given_name": "Jon", "clpid": "Kapustinsky-J-S" }, { "family_name": "Mocko", "given_name": "Michael", "clpid": "Mocko-M" }, { "family_name": "Nelson", "given_name": "Ron", "clpid": "Nelson-R-O" }, { "family_name": "Wang", "given_name": "Zhehui", "orcid": "0000-0001-7826-4063", "clpid": "Wang-Zhehui" } ], "abstract": "One crucial issue for applications of inorganic scintillators in future HEP experiments is radiation damage in a severe radiation environment, such as the HL-LHC. While radiation damage induced by ionization dose is well understood, investigations are on-going to understand radiation damage induced by hadrons, including both charged hadrons and neutrons. Aiming at understanding neutron induced radiation damage in fast inorganic scintillators, BaF_2, LYSO/LFS and PWO crystals were irradiated at LANSCE by a combination of particles, including neutrons, protons and \u03b3-rays. The results indicate that LYSO/LFS and BaF_2 crystal plates are radiation hard up to 4 \u00d7 10^(15) fast neutrons/cm^2.", "doi": "10.1088/1742-6596/1162/1/012020", "issn": "1742-6596", "publisher": "IOP", "publication": "Journal of Physics: Conference Series", "publication_date": "2019-01", "series_number": "1", "volume": "1162", "issue": "1", "pages": "Art. No. 012020" }, { "id": "authors:2thnx-x1f55", "collection": "authors", "collection_id": "2thnx-x1f55", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20181207-083715563", "type": "article", "title": "La and La/Ce Doped BaF_2 Crystals for Future HEP Experiments at the Energy and Intensity Frontiers Part II", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Chen", "given_name": "Junfeng", "orcid": "0000-0003-3863-3324", "clpid": "Chen-Junfeng" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Hu", "given_name": "Chen", "orcid": "0000-0002-3285-4831", "clpid": "Hu-Chen" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" } ], "abstract": "In addition to La-doped barium fluoride (BaF_2) crystals, La/Ce co-doped BaF_2 crystals were also investigated at the California Institute of Technology, Pasadena, CA, USA. Strong cerium-induced emissions peaked at 305 and 320 nm with a decay time of 25 ns were observed, in addition to the fast and slow scintillation at 220 and 300 nm, respectively. The La/Ce co-doping was also found effective in suppressing the slow component in BaF_2. Compared to La-doped crystals, the La/Ce co-doped crystals have a better light output in both 50- and 2500-ns gate. The fast/slow ratio of La/Ce co-doped crystal was found to be about 1/1, similar to La-doping, which is also considered not sufficient for pile-up suppression. A 20-cm-long La/Ce co-doped BaF_2 crystal shows also excellent optical quality and light response uniformity.", "doi": "10.1109/tns.2018.2884975", "issn": "0018-9499", "publisher": "IEEE", "publication": "IEEE Transactions on Nuclear Science", "publication_date": "2019-01", "series_number": "1", "volume": "66", "issue": "1", "pages": "512-518" }, { "id": "authors:tzfyb-6yf51", "collection": "authors", "collection_id": "tzfyb-6yf51", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20181022-155441897", "type": "article", "title": "Radiosensitization by a Pyrrole-Imidazole Polyamide Through Interference with DNA Repair", "author": [ { "family_name": "Diaz-Perez", "given_name": "S.", "clpid": "Diaz-Perez-S" }, { "family_name": "Kane", "given_name": "N.", "clpid": "Kane-N" }, { "family_name": "Yang", "given_name": "F.", "clpid": "Yang-Fan" }, { "family_name": "Kurmis", "given_name": "A. A.", "clpid": "Kurmis-A-A" }, { "family_name": "Kummer", "given_name": "N. T., Jr.", "clpid": "Kummer-N-T" }, { "family_name": "Dervan", "given_name": "P. B.", "orcid": "0000-0001-8852-7306", "clpid": "Dervan-P-B" }, { "family_name": "Nickols", "given_name": "N.", "clpid": "Nickols-N-G" } ], "abstract": "Non-genotoxic small molecules that potentiate the\neffects of ionizing radiation in malignant cells could be used to augment radiotherapy for solid tumors. Pyrrole-imidazole (PyeIm) polyamides are synthetic non-genotoxic DNA minor groove-binding small molecules with\nprogrammable sequence specificity; binding to DNA induces allosteric changes that can interfere with protein-DNA interactions. We hypothesized that PyeIm polyamides can modulate the cellular response to ionizing radiation.", "doi": "10.1016/j.ijrobp.2018.07.604", "issn": "0360-3016", "publisher": "Elsevier", "publication": "International Journal of Radiation Oncology Biology Physics", "publication_date": "2018-11-01", "series_number": "3, Supp.", "volume": "102", "issue": "3, Supp.", "pages": "e155" }, { "id": "authors:kbxs3-ack88", "collection": "authors", "collection_id": "kbxs3-ack88", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20181108-091508452", "type": "article", "title": "Slow Scintillation Component and Radiation-Induced Readout Noise in Undoped CsI Crystals", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Hu", "given_name": "Chen", "orcid": "0000-0002-3285-4831", "clpid": "Hu-Chen" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" } ], "abstract": "Because of its fast scintillation and low cost, undoped CsI crystal has been used to construct crystal calorimeters for high-energy physics experiments. Undoped CsI crystal samples from three vendors were investigated at the Caltech Crystal Laboratory. In addition to the 30-ns fast scintillation peaked at 310 nm, a slow scintillation component peaked at 450 nm was found with a decay time of a few microseconds. The intensity of the slow component may be varied from the seed to the tail end, so it affects crystal's light response uniformity. It was also found that the slow component is highly correlated with the radiation-induced readout noise and may be eliminated spectroscopically by using an optical filter. The slow component is believed to be related to impurities and/or defects in the crystal.", "doi": "10.1109/TNS.2018.2868678", "issn": "0018-9499", "publisher": "IEEE", "publication": "IEEE Transactions on Nuclear Science", "publication_date": "2018-10", "series_number": "10", "volume": "65", "issue": "10", "pages": "2716-2723" }, { "id": "authors:mf1m3-y2f95", "collection": "authors", "collection_id": "mf1m3-y2f95", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180105-101227666", "type": "article", "title": "Slow Scintillation Suppression in Yttrium Doped BaF_2 Crystals", "author": [ { "family_name": "Chen", "given_name": "Junfeng", "orcid": "0000-0003-3863-3324", "clpid": "Chen-Junfeng" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" }, { "family_name": "Du", "given_name": "Yong", "orcid": "0000-0002-7595-2853", "clpid": "Du-Yong" }, { "family_name": "Wang", "given_name": "Shaohua", "clpid": "Wang-Shaohua" }, { "family_name": "Sun", "given_name": "Shiyun", "clpid": "Sun-Shiyun" }, { "family_name": "Li", "given_name": "Xiang", "clpid": "Li-Xiang" } ], "abstract": "Barium fluoride (BaF_2) crystal has a fast scintillation light peaked at 195 and 220 nm with a sub-ns decay time. This ultrafast scintillation promises a wide application in an area where extreme fast timing is important, such as future high-energy physics experiments, gigahertz hard X-ray imaging, and time-of-flight positron emission tomography. BaF_2 crystal, however, has also a slow scintillation component peaked at 310 nm with a decay time of about 600 ns, which causes pileup. Suppression of the slow scintillation component by selective doping, such as Ce, La, Tm, and Y, was discussed 20 years ago. In this paper, we report suppression of the slow component in BaF_2 crystals by yttrium doping. Single crystals with 1 at% Y doping were grown by vacuum Bridgman technique at the Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China. Their radioluminescence, optical transmittance, light output, fast/slow ratio, decay kinetics, and light response uniformity were measured. The results show that 1 at% Y doping suppresses the slow scintillation component in BaF 2crystals by a factor of 6, while the fast component remains unaffected.", "doi": "10.1109/TNS.2017.2786042", "issn": "0018-9499", "publisher": "IEEE", "publication": "IEEE Transactions on Nuclear Science", "publication_date": "2018-08", "series_number": "8", "volume": "65", "issue": "8", "pages": "2147-2151" }, { "id": "authors:szt6n-r4196", "collection": "authors", "collection_id": "szt6n-r4196", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180308-112342058", "type": "article", "title": "Proton-Induced Radiation Damage in BaF_2, LYSO and PWO Crystal Scintillators", "author": [ { "family_name": "Hu", "given_name": "Chen", "orcid": "0000-0002-3285-4831", "clpid": "Hu-Chen" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" }, { "family_name": "Kapustinsky", "given_name": "Jon", "clpid": "Kapustinsky-J-S" }, { "family_name": "Nelson", "given_name": "Ron", "clpid": "Nelson-R-O" }, { "family_name": "Wang", "given_name": "Zhehui", "orcid": "0000-0001-7826-4063", "clpid": "Wang-Zhehui" } ], "abstract": "Future high energy physics experiments at the energy and intensity frontiers will face a challenge of severe radiation environment from both ionization dose and charged and neutral hadrons. The high luminosity large hadron collider, for example, will present an environment, where up to 130 Mrad ionization dose, 3\u00d710^(14) charged hadrons/cm^2 and 5\u00d710^(15) neutrons/cm^2 are expected. In this paper, we report our investigation on charged hadron induced radiation damage in BaF_2, LYSO/LFS and PWO crystals up to 3\u00d710^(15) protons/cm^2 by using 800 MeV protons at the Los Alamos Neutron Science Center. Comparison is made between radiation damages induced by protons and ionization dose alone.", "doi": "10.1109/TNS.2018.2808841", "issn": "0018-9499", "publisher": "IEEE", "publication": "IEEE Transactions on Nuclear Science", "publication_date": "2018-04", "series_number": "4", "volume": "65", "issue": "4", "pages": "1018-1024" }, { "id": "authors:gyv86-z1058", "collection": "authors", "collection_id": "gyv86-z1058", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20161121-085144811", "type": "article", "title": "Label Transfer from APOGEE to LAMOST: Precise Stellar Parameters for 450,000 LAMOST Giants", "author": [ { "family_name": "Ho", "given_name": "Anna Y. Q.", "orcid": "0000-0002-9017-3567", "clpid": "Ho-Anna-Y-Q" }, { "family_name": "Ness", "given_name": "Melissa K.", "orcid": "0000-0001-5082-6693", "clpid": "Ness-M-K" }, { "family_name": "Hogg", "given_name": "David W.", "orcid": "0000-0003-2866-9403", "clpid": "Hogg-D-W" }, { "family_name": "Rix", "given_name": "Hans-Walter", "orcid": "0000-0003-4996-9069", "clpid": "Rix-H-W" }, { "family_name": "Liu", "given_name": "Chao", "orcid": "0000-0001-7049-493X", "clpid": "Liu-Chao" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Zhang", "given_name": "Yong", "clpid": "Zhang-Yong" }, { "family_name": "Hou", "given_name": "Yonghui", "clpid": "Hou-Yonghui" }, { "family_name": "Wang", "given_name": "Yuefei", "clpid": "Wang-Yuefei" } ], "abstract": "In this era of large-scale spectroscopic stellar surveys, measurements of stellar attributes (\"labels,\" i.e., parameters and abundances) must be made precise and consistent across surveys. Here, we demonstrate that this can be achieved by a data-driven approach to spectral modeling. With The Cannon, we transfer information from the APOGEE survey to determine precise T_(eff), log g, [Fe/H], and [\u03b1/M] from the spectra of 450,000 LAMOST giants. The Cannon fits a predictive model for LAMOST spectra using 9952 stars observed in common between the two surveys, taking five labels from APOGEE DR12 as ground truth T_(eff), log g, [Fe/H], [\u03b1/M], and K-band extinction A_k. The model is then used to infer T_(eff) , log g, [Fe/H], and [\u03b1/M] for 454,180 giants, 20% of the LAMOST DR2 stellar sample. These are the first [\u03b1/M] values for the full set of LAMOST giants, and the largest catalog of [\u03b1/M] for giant stars to date. Furthermore, these labels are by construction on the APOGEE label scale; for spectra with S/N > 50, cross-validation of the model yields typical uncertainties of 70 K in T_(eff), 0.1 in log g, 0.1 in [Fe/H], and 0.04 in [\u03b1/M], values comparable to the broadly stated, conservative APOGEE DR12 uncertainties. Thus, by using \"label transfer\" to tie low-resolution (LAMOST R \u2248 1800) spectra to the label scale of a much higher-resolution (APOGEE R \u2248 22,500) survey, we substantially reduce the inconsistencies between labels measured by the individual survey pipelines. This demonstrates that label transfer with The Cannon can successfully bring different surveys onto the same physical scale.", "doi": "10.3847/1538-4357/836/1/5", "issn": "0004-637X", "publisher": "American Astronomical Society", "publication": "Astrophysical Journal", "publication_date": "2017-02-03", "series_number": "5", "volume": "836", "issue": "5", "pages": "1-15" }, { "id": "authors:bf044-ske91", "collection": "authors", "collection_id": "bf044-ske91", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20161205-112233707", "type": "article", "title": "Proton-Induced Radiation Damage in Fast Crystal Scintillators", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" }, { "family_name": "Kapustinsky", "given_name": "Jon", "clpid": "Kapustinsky-J-S" }, { "family_name": "Nelson", "given_name": "Ron", "clpid": "Nelson-R-O" }, { "family_name": "Wang", "given_name": "Zhehui", "orcid": "0000-0001-7826-4063", "clpid": "Wang-Zhehui" } ], "abstract": "This paper reports proton-induced radiation damage in fast crystal scintillators. Large size LYSO and CeF_3 crystals of 20 and 15 cm long were irradiated by 800 MeV protons at Los Alamos up to 3.3 \u00d7 10^(14) p/cm^2 with degradation and recovery of their longitudinal transmittance measured in situ. LYSO plates of 14\u00d714\u00d71.5 mm^3 were irradiated by 67 MeV protons at UC Davis up to 9.5 \u00d7 10^(13) p/cm^2, and by 24 GeV protons at CERN up to 6.9 \u00d7 10^(15) p/cm^2. The results show an excellent radiation hardness of LYSO crystals against charged hadrons.", "doi": "10.1109/TNS.2016.2633427", "issn": "0018-9499", "publisher": "IEEE", "publication": "IEEE Transactions on Nuclear Science", "publication_date": "2017-01", "series_number": "1", "volume": "64", "issue": "1", "pages": "665-672" }, { "id": "authors:dcgnj-st855", "collection": "authors", "collection_id": "dcgnj-st855", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180122-091859578", "type": "book_section", "title": "Proton-Induced Radiation Damage in BGO, LFS, PWO and a LFS/W/Quartz Capillary Shashlik cell", "book_title": "2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop (NSS/MIC/RTSD)", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" }, { "family_name": "Kapustinsky", "given_name": "Jon", "clpid": "Kapustinsky-J-S" }, { "family_name": "Nelson", "given_name": "Ron", "clpid": "Nelson-R-O" }, { "family_name": "Wang", "given_name": "Zhehui", "orcid": "0000-0001-7826-4063", "clpid": "Wang-Zhehui" } ], "abstract": "Future high energy physics experiments at the energy and intensity frontiers will face challenges of a severe radiation environment from both ionization dose and charged and neutral hadrons. In this paper, we report an investigation on charged hadron-induced radiation damage in BGO, LYSO/LFS, PWO and a LYSO/W/Capillary shashlik cell by using 800 MeV and 24 GeV protons at LANL and CERN respectively. Degradations in both transmittance and light output are reported. The results show excellent radiation resistance of LYSO/LFS crystals and the LFS/W/Capillary shashlik cell against charged hadrons.", "doi": "10.1109/NSSMIC.2016.8069862", "isbn": "978-1-5090-1643-3", "publisher": "IEEE", "place_of_publication": "Piscataway, NJ", "publication_date": "2016-11", "pages": "1-4" }, { "id": "authors:fsc4k-2rj51", "collection": "authors", "collection_id": "fsc4k-2rj51", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180122-090903467", "type": "book_section", "title": "Slow Scintillation Component and Radiation Induced Readout Noise in Pure CsI Crystals", "book_title": "2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop (NSS/MIC/RTSD)", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" } ], "abstract": "Because of its fast decay time and low cost, pure CsI crystals are used in HEP experiments for fast crystal calorimetry. CsI crystal samples from three vendors were characterized for the Mu2e experiment at Fermilab with data used to define crystal specification. In addition to the fast scintillation component peaked at 310 nm, a slow scintillation component peaked at 450 nm with \u03bcs decay time was detected, which may be eliminated spectroscopically by using optical filters. It was also found that the slow scintillation component and the radiation induced readout noise in CsI crystals are highly correlated. The nature of the slow scintillation component is believed to be defects and/or impurity related.", "doi": "10.1109/NSSMIC.2016.8069692", "isbn": "978-1-5090-1643-3", "publisher": "IEEE", "place_of_publication": "Piscataway, NJ", "publication_date": "2016-11", "pages": "1-4" }, { "id": "authors:jg984-1qh14", "collection": "authors", "collection_id": "jg984-1qh14", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20151207-145716901", "type": "article", "title": "Proton induced radiation damage in fast crystal scintillators", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" }, { "family_name": "Kapustinsky", "given_name": "Jon", "clpid": "Kapustinsky-J-S" }, { "family_name": "Nelson", "given_name": "Ron", "clpid": "Nelson-R-O" }, { "family_name": "Wang", "given_name": "Zhehui", "orcid": "0000-0001-7826-4063", "clpid": "Wang-Zhehui" } ], "abstract": "This paper reports proton induced radiation damage in fast crystal scintillators. A 20 cm long LYSO crystal, a 15 cm long CeF3 crystal and four liquid scintillator based sealed quartz capillaries were irradiated by 800 MeV protons at Los Alamos up to 3.3\u00d710^(14)p/cm^2. Four 1.5 mm thick LYSO plates were irradiated by 24 GeV protons at CERN up to 6.9\u00d710^(15)p/cm^2. The results show an excellent radiation hardness of LYSO crystals against charged hadrons.", "doi": "10.1016/j.nima.2015.11.100", "issn": "0168-9002", "publisher": "Elsevier", "publication": "Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment", "publication_date": "2016-07-11", "volume": "824", "pages": "726-728" }, { "id": "authors:9e5eq-3tb21", "collection": "authors", "collection_id": "9e5eq-3tb21", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180125-123443411", "type": "article", "title": "Performance of Crystal Scintillators in a Severe Radiation Environment Caused by Protons", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" }, { "family_name": "Kapustinsky", "given_name": "Jon", "clpid": "Kapustinsky-J-S" }, { "family_name": "Nelson", "given_name": "Ron", "clpid": "Nelson-R-O" }, { "family_name": "Wang", "given_name": "Zhehui", "orcid": "0000-0001-7826-4063", "clpid": "Wang-Zhehui" } ], "abstract": "Future high energy physics experiments at the energy and intensity frontiers will face challenges from a severe radiation environment caused by both ionization dose and charged and neutral hadrons. This paper reports an investigation on proton induced radiation damage in various crystal scintillators. Large size BGO, LFS and PWO crystals of 18 to 22 cm long were irradiated by 800 MeV protons up to 3 \u00d7 10^(15) p/cm^2 at the WNR facility of LANSCE with longitudinal transmittance measured in situ. LYSO plates of 14 \u00d7 4 \u00d7 1.5 mm^3 were irradiated by 24 GeV protons up to 8.2 \u00d7 10^(15)p/cm^2 at the IRRAD facility of CERN. Degradations in both transmittance and light output are reported. The results show an excellent radiation hardness of LYSO/LFS crystals against charged hadrons.", "doi": "10.1088/1742-6596/928/1/012029", "issn": "1742-6588", "publisher": "IOP", "publication": "Journal of Physics Conference Series", "publication_date": "2016-05", "volume": "928", "pages": "Art. No. 012029" }, { "id": "authors:141j6-xt986", "collection": "authors", "collection_id": "141j6-xt986", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180125-124113538", "type": "article", "title": "Performances of Crystal Scintillators in a Severe Radiation Environment Caused by Gamma Rays", "author": [ { "family_name": "Yang", "given_name": "F", "clpid": "Yang-Fan" }, { "family_name": "Zhang", "given_name": "L. Y.", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "R.-Y.", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" } ], "abstract": "Because of their superb energy resolution and detection efficiency crystal scintillators are widely used in high energy and nuclear physics experiments. A crucial issue is radiation damage. We report an investigation on \u03b3-ray induced radiation damage in crystal scintillators of large size, including BaF_2, BGO, CeF_3, pure CsI, LSO/LYSO/LFS and PWO with an integrated dose up to 340 Mrad at a dose rate up to 1 Mrad/h. Optical and scintillation properties of these crystal samples were measured before and after irradiations. The result shows that pure CsI crystals have good radiation hardness below 100 krad. BaF_2, BGO and LYSO crystals show good radiation hardness beyond 1 Mrad. In terms of light output degradation LSO/LYSO/LFS is clearly the best among all scintillation crystals.", "doi": "10.1088/1742-6596/928/1/012032", "issn": "1742-6588", "publisher": "IOP", "publication": "Journal of Physics Conference Series", "publication_date": "2016-05", "volume": "928", "pages": "Art. No. 012032" }, { "id": "authors:ajt41-s0360", "collection": "authors", "collection_id": "ajt41-s0360", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20160404-104103120", "type": "article", "title": "Photoelectrochemical Behavior of n-Type GaAs(100) Electrodes Coated by a Single Layer of Graphene", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Nielander", "given_name": "Adam C.", "orcid": "0000-0002-3639-2427", "clpid": "Nielander-A-C" }, { "family_name": "Grimm", "given_name": "Ronald L.", "orcid": "0000-0003-0407-937X", "clpid": "Grimm-R-L" }, { "family_name": "Lewis", "given_name": "Nathan S.", "orcid": "0000-0001-5245-0538", "clpid": "Lewis-N-S" } ], "abstract": "Methods for cell-selective analysis of proteome dynamics will facilitate studies of biological processes in multicellular organisms. Here we describe a mutant murine methionyl-tRNA synthetase (designated L274GMmMetRS) that charges the noncanonical amino acid azidonorleucine (Anl) to elongator tRNA^(Met) in hamster (CHO), monkey (COS7), and human (HeLa) cell lines. Proteins made in cells that express the synthetase can be labeled with Anl, tagged with dyes or affinity reagents, and enriched on affinity resin to facilitate identification by mass spectrometry. The method does not require expression of orthogonal tRNAs or depletion of canonical amino acids. Successful labeling of proteins with Anl in several mammalian cell lines demonstrates the utility of L274GMmMetRS as a tool for cell-selective analysis of mammalian protein synthesis.", "doi": "10.1021/acs.jpcc.6b00232", "issn": "1932-7447", "publisher": "American Chemical Society", "publication": "Journal of Physical Chemistry C", "publication_date": "2016-04-07", "series_number": "13", "volume": "120", "issue": "13", "pages": "6989-6995" }, { "id": "authors:nz09m-emw91", "collection": "authors", "collection_id": "nz09m-emw91", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20160601-110925910", "type": "article", "title": "Gamma-Ray Induced Radiation Damage Up to 340 Mrad in Various Scintillation Crystals", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" } ], "abstract": "Because of their superb energy resolution and detection efficiency scintillation crystals are widely used in high energy and nuclear physics experiments. A crucial issue is radiation damage in crystals. We report an investigation on \u03b3-ray induced radiation damage in various crystal scintillators of large size, including BaF_2, BGO, CeF_3, pure CsI, LSO/LYSO/LFS and PWO, with an integrated dose up to 340 Mrad and a dose rate up to 1 Mrad/h. Optical and scintillation properties of these crystal samples were measured before and after irradiations. The results show that pure CsI has good radiation hardness below 100 krad. BaF_2, BGO and LYSO have good radiation hardness beyond 1 Mrad. In terms of light output degradation LYSO is clearly the best among all scintillation crystals.", "doi": "10.1109/TNS.2015.2505721", "issn": "0018-9499", "publisher": "IEEE", "publication": "IEEE Transactions on Nuclear Science", "publication_date": "2016-04", "series_number": "2", "volume": "63", "issue": "2", "pages": "612-619" }, { "id": "authors:npf32-bv203", "collection": "authors", "collection_id": "npf32-bv203", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20160426-080840558", "type": "article", "title": "Monitoring LSO/LYSO Crystal Calorimeters", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" } ], "abstract": "LSO/LYSO crystals were chosen by the SuperB, Mu2e and COMET experiments to construct total absorption electromagnetic calorimeters. They were also proposed as the active medium for a Shashlik calorimeter which was one of the two options proposed for the CMS forward calorimeter upgrade at the proposed HL-LHC. Because of the severe radiation environment expected at the HL-LHC, precision light monitoring is crucial for keeping excellent energy resolution promised by LYSO crystals. This paper discusses the wavelength choice for monitoring LYSO based crystal calorimeters. \u03b3-ray induced absorption and light output loss were measured for 20 cm long crystals from five different vendors. Monitoring sensitivity and divergence are analyzed. Two approaches using excitation and emission light and their practical implementations in a beam test at Fermilab are discussed. The response of an LYSO/W Shashlik calorimeter cell after a \u03b3-ray irradiation of 90 Mrad is also presented.", "doi": "10.1109/TNS.2015.2510581", "issn": "0018-9499", "publisher": "IEEE", "publication": "IEEE Transactions on Nuclear Science", "publication_date": "2016-04", "series_number": "2", "volume": "63", "issue": "2", "pages": "605-611" }, { "id": "authors:0gpk4-mt447", "collection": "authors", "collection_id": "0gpk4-mt447", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20160509-113429432", "type": "article", "title": "Radiosensitization by DNA, Binding Pyrrole, Imidazole Polyamides", "author": [ { "family_name": "Kummer", "given_name": "N. T.", "clpid": "Kummer-N-T" }, { "family_name": "Yang", "given_name": "F.", "clpid": "Yang-Fan" }, { "family_name": "Dervan", "given_name": "P.", "orcid": "0000-0001-8852-7306", "clpid": "Dervan-P-B" }, { "family_name": "Nickols", "given_name": "N.", "clpid": "Nickols-N-G" } ], "abstract": "Pyrrole (Py) - Imidazole (Im) polyamides are a class of non-genotoxic DNA-binding small molecules with modular sequence recognition and high affinity. A polyamide targeted to the sequence 5'-WGWWCW-3', corresponding to the Androgen Receptor (AR) Response Element (ARE) half-site, suppresses AR positive prostate tumor xenografts. Evidence for inhibition of DNA dependent processes including allosteric inhibition of AR-DNA interactions and RNA Polymerase II transcription are observed in vitro. It is hypothesized that polyamides may displace DNA repair elements recruited after genotoxic insult and thereby sensitize cells to ionizing radiation.", "doi": "10.1016/j.ijrobp.2015.07.1923", "issn": "0360-3016", "publisher": "Elsevier", "publication": "International Journal of Radiation Oncology Biology Physics", "publication_date": "2015-11-01", "series_number": "3, Supp. 1", "volume": "93", "issue": "3, Supp. 1", "pages": "E537-E538" }, { "id": "authors:ntv29-2mz81", "collection": "authors", "collection_id": "ntv29-2mz81", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20161012-110339515", "type": "book_section", "title": "Studies of Wavelength-Shifting Liquid Filled Quartz Capillaries for Use in a Proposed CMS Calorimeter", "book_title": "Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2015", "author": [ { "family_name": "Baumbaugh", "given_name": "B.", "clpid": "Baumbaugh-B" }, { "family_name": "Bornheim", "given_name": "A.", "orcid": "0000-0002-0128-0871", "clpid": "Bornheim-A" }, { "family_name": "Newman", "given_name": "H. B.", "orcid": "0000-0003-0964-1480", "clpid": "Newman-H-B" }, { "family_name": "Spiropulu", "given_name": "M.", "orcid": "0000-0001-8172-7081", "clpid": "Spiropulu-M" }, { "family_name": "Yang", "given_name": "F.", "clpid": "Yang-Fan" }, { "family_name": "Zhang", "given_name": "L.", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "R. Y.", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" } ], "abstract": "Studies have been done and continue on the design and construction of a Shashlik detector using Radiation hard quartz capillaries filled with wavelength shifting liquid to collect the scintillation light from LYSO crystals for use as a calorimeter in the Phase II CMS upgrade at CERN. The work presented here focuses on the studies of the capillaries and liquids that would best suit the purpose of the detector. Comparisons are made of various liquids, concentrations, and capillary construction techniques will be discussed.", "doi": "10.1109/NSSMIC.2015.7581951", "isbn": "978-1-4673-9862-6", "publisher": "IEEE", "place_of_publication": "Piscataway, NJ", "publication_date": "2015-11", "pages": "1-6" }, { "id": "authors:66hw7-jws13", "collection": "authors", "collection_id": "66hw7-jws13", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20150804-104946656", "type": "article", "title": "Interface engineering of the photoelectrochemical performance of Ni-oxide-coated n-Si photoanodes by atomic-layer deposition of ultrathin films of cobalt oxide", "author": [ { "family_name": "Zhou", "given_name": "Xinghao", "orcid": "0000-0001-9229-7670", "clpid": "Zhou-Xinghao" }, { "family_name": "Liu", "given_name": "Rui", "clpid": "Liu-Rui" }, { "family_name": "Sun", "given_name": "Ke", "orcid": "0000-0001-8209-364X", "clpid": "Sun-Ke" }, { "family_name": "Friedrich", "given_name": "Dennis", "orcid": "0000-0003-4844-368X", "clpid": "Friedrich-Dennis" }, { "family_name": "McDowell", "given_name": "Matthew T.", "orcid": "0000-0001-5552-3456", "clpid": "McDowell-Matthew-T" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Omelchenko", "given_name": "Stefan T.", "orcid": "0000-0003-1104-9291", "clpid": "Omelchenko-Stefan-T" }, { "family_name": "Saadi", "given_name": "Fadl H.", "orcid": "0000-0003-3941-0464", "clpid": "Saadi-Fadl-H" }, { "family_name": "Nielander", "given_name": "Adam C.", "orcid": "0000-0002-3639-2427", "clpid": "Nielander-Adam-C" }, { "family_name": "Yalamanchili", "given_name": "Sisir", "clpid": "Yalamanchili-Sisir" }, { "family_name": "Papadantonakis", "given_name": "Kimberly M.", "orcid": "0000-0002-9900-5500", "clpid": "Papadantonakis-Kimberly-M" }, { "family_name": "Brunschwig", "given_name": "Bruce S.", "orcid": "0000-0002-6135-6727", "clpid": "Brunschwig-B-S" }, { "family_name": "Lewis", "given_name": "Nathan S.", "orcid": "0000-0001-5245-0538", "clpid": "Lewis-N-S" } ], "abstract": "Introduction of an ultrathin (2 nm) film of cobalt oxide (CoO_x) onto n-Si photoanodes prior to sputter-deposition of a thick multifunctional NiO_x coating yields stable photoelectrodes with photocurrent-onset potentials of ~\u2212240 mV relative to the equilibrium potential for O2(g) evolution and current densities of ~28 mA cm^(\u22122) at the equilibrium potential for water oxidation when in contact with 1.0 M KOH(aq) under 1 sun of simulated solar illumination. The photoelectrochemical performance of these electrodes was very close to the Shockley diode limit for moderately doped n-Si(100) photoelectrodes, and was comparable to that of typical protected Si photoanodes that contained np+ buried homojunctions.", "doi": "10.1039/c5ee01687h", "issn": "1754-5692", "publisher": "Royal Society of Chemistry", "publication": "Energy and Environmental Science", "publication_date": "2015-09-01", "series_number": "9", "volume": "8", "issue": "9", "pages": "2644-2649" }, { "id": "authors:8zp45-d9b52", "collection": "authors", "collection_id": "8zp45-d9b52", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20151119-141921514", "type": "article", "title": "DNA Repair Interference with Sequence Specific DNA Binding Pyrrole Imidazole Polyamides; a Novel Radiation Sensitizer", "author": [ { "family_name": "Kummer", "given_name": "N. T.", "clpid": "Kummer-N-T" }, { "family_name": "Yang", "given_name": "F.", "clpid": "Yang-Fan" }, { "family_name": "Dervan", "given_name": "P. B.", "orcid": "0000-0001-8852-7306", "clpid": "Dervan-P-B" }, { "family_name": "Nickols", "given_name": "N. G.", "clpid": "Nickols-N-G" } ], "abstract": "Pyrrole (Py)\u2014Imidazole (Im) polyamides are a class of non-genotoxic DNA-binding small molecules with modular sequence recognition and high affinity. A polyamide targeted to the Androgen Receptor (AR) Response Element (ARE) half-site, suppresses AR positive prostate tumor xenografts. It is hypothesized that polyamides may displace DNA repair elements recruited after genotoxic insult and thereby sensitize cells to ionizing radiation. DNA double strand repair was assessed in a cell-free system using PC3 cell lysate, and a linearized pGEM3Z plasmid containing an insert with a BamH1 restriction site flanked by polyamide binding site motifs, and analyzed by qPCR. Rejoining of the linearized plasmid was reduced by 85 % and inhibited rejoining by DNA ligase compared to untreated controls. Neutral comet assay revealed no genomic fragmentation after 48 h of 10 \u00b5M polyamide treatment. Genomic fragmentation was statistically similar 1 h post radiation with 10 Gy, +/\u2212 polyamide. However, at 24 h post radiation, cells pretreated with 10 \u00b5M polyamide had persistently elevated tail lengths (181 vs. 129 p < 0.001) and tail moment (103 vs 74 p < 0.001). After radiation, greater than 95 % of cells +/\u2212 10 \u00b5M polyamide pretreatment demonstrated increased \u03b3-H2AX phosphorylation. 24 h post RT, 32% of polyamide treated cells continued to have elevated \u03b3-H2AX phosphorylation, whereas only 19% of untreated cells continued to have elevated \u03b3-H2AX phosphorylation. Polyamide treatment with 10 mM resulted in a sensitization enhancement ratio of 2.48 at 4 Gy by clonogenic assay. In conclusion Py-Im polyamides are non-genotoxic and sequence specific; potentially offering a strategy for sequence-directed interference with DNA repair and other DNA-depended processes.", "doi": "10.1007/s00066-015-0903-6", "issn": "0179-7158", "publisher": "Springer", "publication": "Strahlentherapie und Onkologie", "publication_date": "2015-06-11", "series_number": "11", "volume": "191", "issue": "11", "pages": "902-903" }, { "id": "authors:4ze06-yjs24", "collection": "authors", "collection_id": "4ze06-yjs24", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20141222-111840315", "type": "article", "title": "Characterization of three LYSO crystal batches", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Mao", "given_name": "Rihua", "clpid": "Mao-Rihua" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" } ], "abstract": "We report on three LYSO crystal batches characterized at the Caltech crystal laboratory for future HEP experiments: 25 20 cm long crystals for the SuperB experiment; 12 13 cm long crystals for the Mu2e experiment and 623 14\u00d714\u00d71.5 mm^3 plates with five holes for a LYSO/W Shashlik matrix for a beam test at Fermilab. Optical and scintillation properties measured are longitudinal transmittance, light output and FWHM energy resolution. Correlations between these properties are also investigated.", "doi": "10.1016/j.nima.2014.11.103", "issn": "0168-9002", "publisher": "Elsevier", "publication": "Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment", "publication_date": "2015-06-01", "volume": "784", "pages": "105-110" }, { "id": "authors:x4wzy-t0e60", "collection": "authors", "collection_id": "x4wzy-t0e60", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20151013-154644445", "type": "book_section", "title": "Thin scintillators for ultrafast hard X-ray imaging", "book_title": "Photon Counting Applications 2015", "author": [ { "family_name": "Wang", "given_name": "Zhehui", "orcid": "0000-0001-7826-4063", "clpid": "Wang-Zhehui" }, { "family_name": "Barnes", "given_name": "Cris W.", "clpid": "Barnes-C-W" }, { "family_name": "Kapustinsky", "given_name": "Jon S.", "clpid": "Kapustinsky-J-S" }, { "family_name": "Morris", "given_name": "Chris L.", "orcid": "0000-0003-2141-0255", "clpid": "Morris-C-L" }, { "family_name": "Nelson", "given_name": "Ron O.", "clpid": "Nelson-R-O" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" } ], "contributor": [ { "family_name": "Prochazka", "given_name": "Ivan", "clpid": "Prochazka-I" }, { "family_name": "Sobolewski", "given_name": "Roman", "clpid": "Sobolewski-R" }, { "family_name": "James", "given_name": "Ralph B.", "clpid": "James-R-B" } ], "abstract": "A multilayer thin-scintillator concept is described for ultrafast imaging. The individual layer thickness is determined by the spatial resolution and light attenuation length, the number of layers is determined by the overall efficiency. By coating the scintillators with a high quantum-efficiency photocathode, single X-ray photon detection can be achieved using fast scintillators with low light yield. The fast, efficient sensors, when combined with MCP and novel nanostructed electron amplification schemes, is a possible way towards GHz hard X-ray cameras for a few frames of images.", "doi": "10.1117/12.2178420", "isbn": "978-1-62841-625-1", "publisher": "Society of Photo-Optical Instrumentation Engineers", "place_of_publication": "Bellingham, WA", "publication_date": "2015-05-06", "pages": "Art. No. 95040N" }, { "id": "authors:ft6sa-gk325", "collection": "authors", "collection_id": "ft6sa-gk325", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20150202-095259720", "type": "article", "title": "Stable Solar-Driven Water Oxidation to O_2(g) by Ni-Oxide-Coated Silicon Photoanodes", "author": [ { "family_name": "Sun", "given_name": "Ke", "orcid": "0000-0001-8209-364X", "clpid": "Sun-Ke" }, { "family_name": "McDowell", "given_name": "Matthew T.", "orcid": "0000-0001-5552-3456", "clpid": "McDowell-M-T" }, { "family_name": "Nielander", "given_name": "Adam C.", "orcid": "0000-0002-3639-2427", "clpid": "Nielander-A-C" }, { "family_name": "Hu", "given_name": "Shu", "orcid": "0000-0002-5041-0169", "clpid": "Hu-Shu" }, { "family_name": "Shaner", "given_name": "Matthew R.", "orcid": "0000-0003-4682-9757", "clpid": "Shaner-M-R" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Brunschwig", "given_name": "Bruce S.", "orcid": "0000-0002-6135-6727", "clpid": "Brunschwig-B-S" }, { "family_name": "Lewis", "given_name": "Nathan S.", "orcid": "0000-0001-5245-0538", "clpid": "Lewis-N-S" } ], "abstract": "Semiconductors with small band gaps (<2 eV) must be stabilized against corrosion or passivation in aqueous electrolytes before such materials can be used as photoelectrodes to directly produce fuels from sunlight. In addition, incorporation of electrocatalysts on the surface of photoelectrodes is required for efficient oxidation of H_2O to O_2(g) and reduction of H_2O or H_2O and CO_2 to fuels. We report herein the stabilization of np^+-Si(100) and n-Si(111) photoanodes for over 1200 h of continuous light-driven evolution of O_2(g) in 1.0 M KOH(aq) by an earth-abundant, optically transparent, electrocatalytic, stable, conducting nickel oxide layer. Under simulated solar illumination and with optimized index-matching for proper antireflection, NiO_x-coated np+-Si(100) photoanodes produced photocurrent-onset potentials of \u2212180 \u00b1 20 mV referenced to the equilibrium potential for evolution of O_2(g), photocurrent densities of 29 \u00b1 1.8 mA cm^(\u20132) at the equilibrium potential for evolution of O_2(g), and a solar-to-O_2(g) conversion figure-of-merit of 2.1%.", "doi": "10.1021/jz5026195", "issn": "1948-7185", "publisher": "American Chemical Society", "publication": "Journal of Physical Chemistry Letters", "publication_date": "2015-02-19", "series_number": "4", "volume": "6", "issue": "4", "pages": "592-598" }, { "id": "authors:f26f8-j6p42", "collection": "authors", "collection_id": "f26f8-j6p42", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20150507-150447530", "type": "article", "title": "Monitoring LSO/LYSO Crystal Based Calorimeters", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" } ], "abstract": "Precision light monitoring is important for keeping excellent energy resolution promised by LSO/LYSO crystals in severe radiation environment. In this paper, we report an investigation on the wavelength choice for monitoring LYSO crystal based calorimeters. Gamma-ray induced absorption and light output loss were measured for 20 cm long crystals from five different vendors. Monitoring sensitivity and divergence between crystals from different vendors were investigated. The pros and cons of two monitoring approaches using emission and excitation light and their practical implementation for a LYSO/W Shashlik test beam matrix are discussed.", "doi": "10.1088/1742-6596/587/1/012066", "issn": "1742-6596", "publisher": "IOP", "publication": "Journal of Physics: Conference Series", "publication_date": "2015-02-13", "series_number": "1", "volume": "587", "issue": "1", "pages": "Art. No. 012066" }, { "id": "authors:f456b-ke268", "collection": "authors", "collection_id": "f456b-ke268", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20150507-143919081", "type": "article", "title": "BSO Crystals for the HHCAL Detector Concept", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Yuan", "given_name": "Hui", "clpid": "Yuan-Hui" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" } ], "abstract": "We report an investigation on optical and scintillation properties and radiation hardness of four 20 cm long BSO crystals grown at SIC for the HHCAL detector concept. Their optical and scintillation properties, such as longitudinal transmittance, light output and light response uniformity, were measured before and after \u03b3-ray irradiation. Progresses are observed in optical quality, light output and radiation hardness. Their use for HHCAL concept is discussed.", "doi": "10.1088/1742-6596/587/1/012064", "issn": "1742-6588", "publisher": "IOP", "publication": "Journal of Physics Conference Series", "publication_date": "2015-02-13", "series_number": "1", "volume": "587", "issue": "1", "pages": "Art. No. 012064" }, { "id": "authors:8v5gg-y4z39", "collection": "authors", "collection_id": "8v5gg-y4z39", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20150507-144847772", "type": "article", "title": "Characterization of Three LYSO Crystal Batches", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Mao", "given_name": "Rihua", "clpid": "Mao-Rihua" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" } ], "abstract": "We report on three LYSO crystal batches characterized at the Caltech crystal laboratory for future HEP experiments: Twenty-five 20 cm long crystals for the SuperB experiment; twelve 13 cm long crystals for the Mu2e experiment and 623 14\u00d714\u00d71.5 mm plates with five holes for a LYSO/W Shashlik matrix for a beam test at Fermilab. Optical and scintillation properties measured are longitudinal Transmittance, light output and FWHM energy resolution. Correlations between these properties are also investigated.", "doi": "10.1088/1742-6596/587/1/012065", "issn": "1742-6588", "publisher": "IOP", "publication": "Journal of Physics Conference Series", "publication_date": "2015-02-13", "volume": "587", "pages": "Art. No. 012065" }, { "id": "authors:6hcdb-j9406", "collection": "authors", "collection_id": "6hcdb-j9406", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20141113-111008849", "type": "article", "title": "Low Temperature Solution-Phase Deposition of SnS Thin Films", "author": [ { "family_name": "Antunez", "given_name": "Priscilla D.", "clpid": "Antunez-P-D" }, { "family_name": "Torelli", "given_name": "Daniel A.", "orcid": "0000-0002-6222-817X", "clpid": "Torelli-D-A" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Rabuffetti", "given_name": "Federico A.", "orcid": "0000-0001-8500-3427", "clpid": "Rabuffetti-F-A" }, { "family_name": "Lewis", "given_name": "Nathan S.", "orcid": "0000-0001-5245-0538", "clpid": "Lewis-N-S" }, { "family_name": "Brutchey", "given_name": "Richard L.", "orcid": "0000-0002-7781-5596", "clpid": "Brutchey-R-L" } ], "abstract": "The solution-phase deposition of inorganic semiconductors\nis a promising, scalable method for the manufacture of\nthin film photovoltaics. Deposition of photovoltaic materials\nfrom molecular or colloidal inks offers the possibility of\ninexpensive, rapid, high-throughput thin film fabrication\nthrough processes such as spray coating. For example, CdTe,\nCu(In,Ga)(S,Se)_2 (CIGS), and CH_3NH_3Pb(Cl,I)_3 perovskite-based\nthin film solar cells have been previously deposited using\nsolution-based processes. Inks have also recently been\ndeveloped for the solution deposition of Cu_2ZnSn(S,Se)_4\n(CZTS) and FeS_2 (iron pyrite) absorber layers for thin film\nsolar applications, in order to provide sustainable alternatives to\nmaterials that contain environmentally harmful heavy metals\n(e.g., Cd, Pb) and/or scarce elements (e.g., Te, In).", "doi": "10.1021/cm503124u", "issn": "0897-4756", "publisher": "American Chemical Society", "publication": "Chemistry of Materials", "publication_date": "2014-10-14", "series_number": "19", "volume": "26", "issue": "19", "pages": "5444-5446" }, { "id": "authors:w06wr-5cc46", "collection": "authors", "collection_id": "w06wr-5cc46", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20140512-134025441", "type": "article", "title": "CsI:Tl^+,Yb^(2+): ultra-high light yield scintillator with reduced afterglow", "author": [ { "family_name": "Wu", "given_name": "Yuntao", "clpid": "Wu-Yuntao" }, { "family_name": "Ren", "given_name": "Guohao", "clpid": "Ren-Guohao" }, { "family_name": "Nikl", "given_name": "Martin", "clpid": "Nikl-Martin" }, { "family_name": "Chen", "given_name": "Xiaofeng", "clpid": "Chen-Xiaofeng" }, { "family_name": "Ding", "given_name": "Dongzhou", "clpid": "Ding-Dongzhou" }, { "family_name": "Li", "given_name": "Huanyin", "clpid": "Li-Huanyin" }, { "family_name": "Pan", "given_name": "Shangke", "clpid": "Pan-Shangke" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" } ], "abstract": "The afterglow problem has been preventing CsI:Tl single crystal scintillators from being used for applications in the field of computer tomography and high-speed imaging. We show that Yb^(2+) codoping in CsI:Tl can reduce it at least by one order of magnitude after 50 ms from X-ray cut-off compared to ordinary CsI:Tl. After optimization of the Yb^(2+) and Tl^+ concentrations, the doubly doped CsI:Tl,Yb crystal exhibits an ultra-high light yield of 90 000 \u00b1 6000 photons MeV^(\u22121), energy resolution 7.9%@511 keV and low afterglow level of about 0.035% at 80 ms. Simultaneous improvement in afterglow, light yield and energy resolution in CsI:Tl-based scintillators paves the way to its application in computer tomography and high-speed imaging. The physical mechanism and role of ytterbium ions in afterglow suppression are proposed.", "doi": "10.1039/C3CE42645A", "issn": "1466-8033", "publisher": "Royal Society of Chemistry", "publication": "CrystEngComm", "publication_date": "2014-04-28", "series_number": "16", "volume": "16", "issue": "16", "pages": "3312-3317" }, { "id": "authors:04dcg-0c828", "collection": "authors", "collection_id": "04dcg-0c828", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20140529-114204750", "type": "article", "title": "Doped Lead Fluoride Chloride Crystals for the HHCAL Detector Concept", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Zhang", "given_name": "Guoqing", "clpid": "Zhang-Guoqing" }, { "family_name": "Ren", "given_name": "Guohao", "clpid": "Ren-Guohao" }, { "family_name": "Mao", "given_name": "Rihua", "clpid": "Mao-Rihua" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" } ], "abstract": "We report an investigation on pure and doped PbFCl crystals. Optical and scintillation properties, such as emission and transmittance spectra, light output and decay kinetics, were measured at different temperatures. Three emission bands at 2.27, 2.85 and 3.39 eV are observed at 77 K. Thermal quenching effect is also observed. While a scintillation component peaked at 400 nm with 3 ns decay time is observed in all PbFCl samples, a secondary emission at 550 nm with 360 ns decay time is found in the K doped PbFCl samples. The origins of three emission bands and further development of PbFCl for the HHCAL detector concept are discussed.", "doi": "10.1109/TNS.2013.2281317", "issn": "0018-9499", "publisher": "IEEE", "publication": "IEEE Transactions on Nuclear Science", "publication_date": "2014-02", "series_number": "1", "volume": "61", "issue": "1", "pages": "489-494" }, { "id": "authors:nmnzs-3pq69", "collection": "authors", "collection_id": "nmnzs-3pq69", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20221017-72823300.1", "type": "article", "title": "Photoelectrochemical Behavior of n-Type Si(111) Electrodes Coated With a Single Layer of Graphene", "author": [ { "family_name": "Nielander", "given_name": "Adam C.", "orcid": "0000-0002-3639-2427", "clpid": "Nielander-Adam-C" }, { "family_name": "Bierman", "given_name": "Matthew J.", "orcid": "0000-0002-9053-6356", "clpid": "Bierman-Matthew-J" }, { "family_name": "Petrone", "given_name": "Nicholas", "orcid": "0000-0003-1995-4077", "clpid": "Petrone-Nicholas-W" }, { "family_name": "Strandwitz", "given_name": "Nicholas C.", "orcid": "0000-0001-6159-9430", "clpid": "Strandwitz-Nicholas-C" }, { "family_name": "Ardo", "given_name": "Shane", "orcid": "0000-0001-7162-6826", "clpid": "Ardo-Shane" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Hone", "given_name": "James", "orcid": "0000-0002-8084-3301", "clpid": "Hone-James" }, { "family_name": "Lewis", "given_name": "Nathan S.", "orcid": "0000-0001-5245-0538", "clpid": "Lewis-N-S" } ], "abstract": "The behavior of graphene-coated n-type Si(111) photoanodes was compared to the behavior of H-terminated n-type Si(111) photoanodes in contact with aqueous K\u2083[Fe(CN)\u2086]/K\u2084[Fe(CN)\u2086] as well as in contact with a series of outer-sphere, one-electron redox couples in nonaqueous electrolytes. The n-Si/Graphene electrodes exhibited stable short-circuit photocurrent densities of over 10 mA cm\u207b\u00b2 for >1000 s of continuous operation in aqueous electrolytes, whereas n-Si\u2013H electrodes yielded a nearly complete decay of the current density within \u223c100 s. The values of the open-circuit photovoltages and the flat-band potentials of the Si were a function of both the Fermi level of the graphene and the electrochemical potential of the electrolyte solution, indicating that the n-Si/Graphene did not form a buried junction with respect to the solution contact.", "doi": "10.1021/ja407462g", "issn": "0002-7863", "publisher": "American Chemical Society", "publication": "Journal of the American Chemical Society", "publication_date": "2013-11-20", "series_number": "46", "volume": "135", "issue": "46", "pages": "17246-17249" }, { "id": "authors:x55pf-b7h51", "collection": "authors", "collection_id": "x55pf-b7h51", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20131113-084041726", "type": "article", "title": "Photoelectrochemical Behavior of n\u2011Type Si(111) Electrodes Coated With a Single Layer of Graphene", "author": [ { "family_name": "Nielander", "given_name": "Adam C.", "orcid": "0000-0002-3639-2427", "clpid": "Nielander-A-C" }, { "family_name": "Bierman", "given_name": "Matthew J.", "clpid": "Bierman-M-J" }, { "family_name": "Petrone", "given_name": "Nicholas", "clpid": "Petrone-N" }, { "family_name": "Strandwitz", "given_name": "Nicholas C.", "clpid": "Strandwitz-N-C" }, { "family_name": "Ardo", "given_name": "Shane", "orcid": "0000-0001-7162-6826", "clpid": "Ardo-S" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Hone", "given_name": "James", "orcid": "0000-0002-8084-3301", "clpid": "Hone-J" }, { "family_name": "Lewis", "given_name": "Nathan S.", "orcid": "0000-0001-5245-0538", "clpid": "Lewis-N-S" } ], "abstract": "The behavior of graphene-coated n-type Si(111) photoanodes was compared to the behavior of H-terminated n-type Si(111) photoanodes in contact with aqueous K_3[Fe(CN)_6]/K_4[Fe(CN)_6] as well as in contact with a series of outer-sphere, one-electron redox couples in nonaqueous electrolytes. The n-Si/Graphene electrodes exhibited stable short-circuit photocurrent densities of over 10 mA cm^(\u20132) for >1000 s of continuous operation in aqueous electrolytes, whereas n-Si\u2013H electrodes yielded a nearly complete decay of the current density within 100 s. The values of the open-circuit photovoltages and the flat-band potentials of the Si were a function of both the Fermi level of the graphene and the electrochemical potential of the electrolyte solution, indicating that the n-Si/Graphene did not form a buried junction with respect to the solution contact.", "doi": "10.1021/ja407462g", "issn": "0002-7863", "publisher": "American Chemical Society", "publication": "Journal of the American Chemical Society", "publication_date": "2013-10-14" }, { "id": "authors:7wnb9-8bm21", "collection": "authors", "collection_id": "7wnb9-8bm21", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20131126-094428309", "type": "article", "title": "Radiosensitization by High Affinity Programmable Minor Groove\n Binders", "author": [ { "family_name": "Nickols", "given_name": "N.", "clpid": "Nickols-N-G" }, { "family_name": "Yang", "given_name": "F.", "clpid": "Yang-Fan" }, { "family_name": "Ratikan", "given_name": "J. A.", "clpid": "Ratikan-J-A" }, { "family_name": "Li", "given_name": "B. C.", "clpid": "Li-B-C" }, { "family_name": "McBride", "given_name": "W. H.", "clpid": "McBride-W-H" }, { "family_name": "Dervan", "given_name": "P. B.", "orcid": "0000-0001-8852-7306", "clpid": "Dervan-P-B" } ], "abstract": "Non-genotoxic small molecules of low systemic toxicity that can potentiate the effects of radiation could be valuable adjuvant therapeutics for solid tumors. Pyrrole-imidazole (Py-Im) polyamides are synthetic oligomers that bind the minor groove of DNA non-covalently with programmable sequence recognition and high affinity. We reported that a polyamide targeted to the DNA sequence 5'-WGWWCW-3' (W = A/T) suppressed growth of prostate tumor xenografts. In cell culture, this polyamide interferes with RNA Polymerase II activity and results in a dose-dependent depletion of the RNA Polymerase II large subunit. We hypothesized that high-affinity DNA binding Py-Im polyamides may enhance the effects of ionizing radiation.", "doi": "10.1016/j.ijrobp.2013.06.1725", "issn": "0360-3016", "publisher": "Elsevier", "publication": "International Journal of Radiation Oncology Biology Physics", "publication_date": "2013-10-01", "series_number": "S2", "volume": "87", "issue": "S2", "pages": "S651-S652" }, { "id": "authors:p8cfk-g1791", "collection": "authors", "collection_id": "p8cfk-g1791", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20130813-093537361", "type": "article", "title": "A Study on Radiation Damage in PWO-II Crystals", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Mao", "given_name": "Rihua", "clpid": "Mao-Rihua" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" } ], "abstract": "We report in this paper an investigation on radiation hardness of 20 cm long PWO-II crystals produced at BTCP for the proposed PANDA experiment at FAIR. The optical and scintillation properties of PWO-II crystals, such as transmittance, light output and light response uniformity, were measured before and after \u03b3-ray irradiations at different dose rates. PWO-II crystals are compared to PWO crystals used in the CMS experiment. Progresses are observed in the light output and the radiation hardness for PWO-II crystals. Its use for crystal calorimeters in future high energy physics experiments is discussed. To maintain crystal precision, a precision light monitoring system is mandatory to follow variations of crystal transparency in situ.", "doi": "10.1109/TNS.2013.2262660", "issn": "0018-9499", "publisher": "IEEE", "publication": "IEEE Transactions on Nuclear Science", "publication_date": "2013-06", "series_number": "3", "volume": "60", "issue": "3", "pages": "2336-2342" }, { "id": "authors:kpmgh-qv739", "collection": "authors", "collection_id": "kpmgh-qv739", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20130219-133540257", "type": "article", "title": "Effects of Zr^(4+) codoping on the Lu_(0.8)Sc_(0.2)BO_3:Ce scintillation materials", "author": [ { "family_name": "Wu", "given_name": "Yuntao", "clpid": "Wu-Yuntao" }, { "family_name": "Ren", "given_name": "Guohao", "clpid": "Ren-Guohao" }, { "family_name": "Ding", "given_name": "Dongzhou", "clpid": "Ding-Dongzhou" }, { "family_name": "Shang", "given_name": "Shanshan", "clpid": "Shang-Shanshan" }, { "family_name": "Sun", "given_name": "Dandan", "clpid": "Sun-Dandan" }, { "family_name": "Zhang", "given_name": "Guoqing", "clpid": "Zhang-Guoqing" }, { "family_name": "Wang", "given_name": "Jiayu", "clpid": "Wang-Jiayu" }, { "family_name": "Pan", "given_name": "Shangke", "clpid": "Pan-Shangke" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" } ], "abstract": "Both Zr-codoped Lu_(0.8)Sc_(0.2)BO_3:Ce polycrystalline powders and single crystals were obtained by solid-state reaction and Czochralski method, respectively. The effects of Zr codoping on the optical absorption, Ce^(3+)/Ce^(4+) ratio, scintillation efficiency, decay time and point defect in Lu_(0.8)Sc_(0.2)BO_3:Ce materials were examined systematically. Our results show that there is no positive contribution of Zr^(4+) ion codoping to the scintillation efficiency. And the reasons for the deterioration of scintillation efficiency by codoping Zr^(4+) were revealed.", "doi": "10.1016/j.jlumin.2012.08.023", "issn": "0022-2313", "publisher": "Elsevier", "publication": "Journal of Luminescence", "publication_date": "2013-02", "volume": "134", "pages": "345-351" }, { "id": "authors:w5ggr-gka95", "collection": "authors", "collection_id": "w5ggr-gka95", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20131213-101040045", "type": "book_section", "title": "A Study on Radiation Hardness of BGO Crystals", "book_title": "2012 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)", "author": [ { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Mao", "given_name": "Rihua", "clpid": "Mao-Rihua" }, { "family_name": "Wang", "given_name": "Shaohua", "clpid": "Wang-Shaohua" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" } ], "abstract": "We report an investigation on the radiation hardness of 20 cm long BGO crystals produced at Shanghai Institute of Ceramics. Their optical and scintillation properties, such as transmittance and emission spectra, light output and response uniformity, were measured before, during and after \u03b3-ray irradiations at 2, 8, 30 and 5,444 rad/h. BGO crystals produced in 2004 and 2011 are compared to a sample grown in early eighties for the L3 experiment at LEP. Significantly better radiation harness is observed in the sample grown in 2011 in transmittance, light output and radiation hardness. Their use for crystal calorimeters in future high energy physics experiments is discussed. To maintain crystal resolution, a precision light monitoring system is mandatory to trace variations of crystal transparency in situ for a BGO crystal calorimeter in a radiation environment. The origin of radiation damage in BGO is also discussed.", "doi": "10.1109/NSSMIC.2012.6551126", "isbn": "978-1-4673-2028-3", "publisher": "IEEE", "place_of_publication": "Piscataway, NJ", "publication_date": "2012-10", "pages": "361-364" }, { "id": "authors:eqa67-axg78", "collection": "authors", "collection_id": "eqa67-axg78", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20131213-094626285", "type": "book_section", "title": "A Study on Radiation Hardness of PWO-II Crystals", "book_title": "2012 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Mao", "given_name": "Rihua", "clpid": "Mao-Rihua" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" } ], "abstract": "We report in this paper an investigation on radiation hardness of 20 cm long PWO-II crystals produced at BTCP for the proposed PANDA experiment at GSI. The optical and scintillation properties of PWO-II crystals, such as transmittance, light output and light response uniformity, were measured before and after \u03b3-ray irradiations at different dose rates. PWO-II crystals are compared to crystals used in the CMS experiment. Progresses are observed in the radiation hardness for PWO-II crystals. Its use for crystal calorimeters in future high energy physics experiments is discussed. To maintain crystal precision, a precision light monitoring system is mandatory to trace variations of crystal transparency in situ for a PWO crystal calorimeter in a radiation environment.", "doi": "10.1109/NSSMIC.2012.6551398", "isbn": "978-1-4673-2028-3", "publisher": "IEEE", "place_of_publication": "Piscataway, NJ", "publication_date": "2012-10", "pages": "1681-1687" }, { "id": "authors:60979-e4f50", "collection": "authors", "collection_id": "60979-e4f50", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20121101-111739624", "type": "article", "title": "Effects of scandium substitution on the crystal structure and luminescence properties of LuBO_3: Ce^(3+)", "author": [ { "family_name": "Wu", "given_name": "Yuntao", "clpid": "Wu-Yuntao" }, { "family_name": "Ren", "given_name": "Guohao", "clpid": "Ren-Guohao" }, { "family_name": "Ding", "given_name": "Dongzhou", "clpid": "Ding-Dongzhou" }, { "family_name": "Pan", "given_name": "Shangke", "clpid": "Pan-Shangke" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" } ], "abstract": "The calcite phase of LuBO_3 and ScBO_3 polycrystalline powders were synthesized by solid state reaction method, and the Lu_(1\u2212x)Sc_xBO_3:Ce (x=0.2, 0.5, 0.7) single crystals were grown by the Czochralski method. A large composition deviation between the initial polycrystalline powders and final single crystal was confirmed by electron probe micro-analysis. Raman spectroscopy revealed that moderate lattice disorder was induced by scandium substitution. However, based on the single crystal X-ray study, we finally concluded that the crystal structure of lutetium scandium orthoborate still crystallized in the rhombohedral system belonging to R3^- c. Furthermore, the relationship between the energies of the five 5d levels of Ce^(3+) and the crystalline environment was revealed. The total redshift, total crystal field splitting, and centroid shift of Lu_(1\u2212x)Sc_xBO_3:Ce^(3+) were calculated based on their VUV excitation spectra. The variations trend of these observed spectroscopic parameters was in accordance with the predicted ones.", "doi": "10.1016/j.jssc.2012.05.001", "issn": "0022-4596", "publisher": "Elsevier", "publication": "Journal of Solid State Chemistry", "publication_date": "2012-10", "volume": "194", "pages": "151-156" }, { "id": "authors:mb73g-asc54", "collection": "authors", "collection_id": "mb73g-asc54", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20131213-090827302", "type": "book_section", "title": "Lead Based Halide Crystals for the HHCAL Detector Concept", "book_title": "2012 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)", "author": [ { "family_name": "Mao", "given_name": "Rihua", "clpid": "Mao-Rihua" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" }, { "family_name": "Chen", "given_name": "Xiaofeng", "clpid": "Chen-Xiaofeng" }, { "family_name": "Li", "given_name": "Huanying", "clpid": "Li-Huanying" }, { "family_name": "Ren", "given_name": "Guohao", "clpid": "Ren-Guohao" }, { "family_name": "Shen", "given_name": "Dingzhong", "clpid": "Shen-Dingzhong" } ], "abstract": "Good UV transmittance and some scintillation light are two requirements for materials to be used to construct a homogeneous hadron calorimeter (HHCAL) capable to measure both Cherenkov and Scintillation light. In this paper we report an investigation on lead based halide crystals for the HHCAL detector concept, including lead fluoride chloride (PbFCI) and gadolinium doped lead fluoride (PbF_2:Gd) crystals grown at Shanghai Institute of Ceramics. The optical and scintillation properties of PbFCI and PbF_2:Gd crystal samples, such as transmittance and photo-/x- luminescence spectra, light output and corresponding decay time, were measured at room temperature. Excellent UV cutoff edge and short decay time were found in PbFCI crystals. Further development work to improve PbFCI quality for the HHCAL project is discussed.", "doi": "10.1109/NSSMIC.2012.6551458", "isbn": "978-1-4673-2028-3", "publisher": "IEEE", "place_of_publication": "Piscataway, NJ", "publication_date": "2012-10", "pages": "1983-1986" }, { "id": "authors:shzj6-9w906", "collection": "authors", "collection_id": "shzj6-9w906", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20120831-114646638", "type": "article", "title": "An algorithm for preferential selection of spectroscopic targets in LEGUE", "author": [ { "family_name": "Carlin", "given_name": "Jeffrey L.", "orcid": "0000-0002-3936-9628", "clpid": "Carlin-J-L" }, { "family_name": "L\u00e9pine", "given_name": "S\u00e9bastien", "orcid": "0000-0002-2437-2947", "clpid": "L\u00e9pine-S" }, { "family_name": "Newberg", "given_name": "Heidi Jo", "clpid": "Newberg-H-J" }, { "family_name": "Deng", "given_name": "Li-Cai", "clpid": "Deng-Li-Cai" }, { "family_name": "Beers", "given_name": "Timothy C.", "orcid": "0000-0003-4573-6233", "clpid": "Beers-T-C" }, { "family_name": "Chen", "given_name": "Yu-Qin", "clpid": "Chen-Yu-Qin" }, { "family_name": "Christlieb", "given_name": "Norbert", "orcid": "0000-0002-4043-2727", "clpid": "Christlieb-N" }, { "family_name": "Fu", "given_name": "Xiao-Ting", "clpid": "Fu-Xiao-Ting" }, { "family_name": "Gao", "given_name": "Shuang", "clpid": "Gao-Shuang" }, { "family_name": "Grillmair", "given_name": "Carl J.", "orcid": "0000-0003-4072-169X", "clpid": "Grillmair-C-J" }, { "family_name": "Guhathakurta", "given_name": "Puragra", "orcid": "0000-0001-8867-4234", "clpid": "Guhathakurta-P" }, { "family_name": "Han", "given_name": "Zhan-Wen", "clpid": "Han-Zhan-Wen" }, { "family_name": "Hou", "given_name": "Jin-Liang", "clpid": "Hou-Jin-Liang" }, { "family_name": "Lee", "given_name": "Hsu-Tai", "clpid": "Lee-Hsu-Tai" }, { "family_name": "Li", "given_name": "Jing", "clpid": "Li-Jing" }, { "family_name": "Liu", "given_name": "Chao", "orcid": "0000-0001-7049-493X", "clpid": "Liu-Chao" }, { "family_name": "Liu", "given_name": "Xiao-Wei", "clpid": "Liu-Xiao-Wei" }, { "family_name": "Pan", "given_name": "Kai-Ke", "clpid": "Pan-Kai-Ke" }, { "family_name": "Sellwood", "given_name": "J. A.", "clpid": "Sellwood-J-A" }, { "family_name": "Wang", "given_name": "Hong-Chi", "clpid": "Wang-Hong-Chi" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Yanny", "given_name": "Brian", "orcid": "0000-0002-9541-2678", "clpid": "Yanny-Brian" }, { "family_name": "Zhang", "given_name": "Yue-Yang", "clpid": "Zhang-Yue-Yang" }, { "family_name": "Zheng", "given_name": "Zheng", "clpid": "Zheng-Zheng" }, { "family_name": "Zhu", "given_name": "Zi", "clpid": "Zhu-Zi" } ], "abstract": "We describe a general target selection algorithm that is applicable to any survey in which the number of available candidates is much larger than the number of objects to be observed. This routine aims to achieve a balance between a smoothly-varying, well-understood selection function and the desire to preferentially select certain types of targets. Some target-selection examples are shown that illustrate different possibilities of emphasis functions. Although it is generally applicable, the algorithm was developed specifically for the LAMOST Experiment for Galactic Understanding and Exploration (LEGUE) survey that will be carried out using the Chinese Guo Shou Jing Telescope. In particular, this algorithm was designed for the portion of LEGUE targeting the Galactic halo, in which we attempt to balance a variety of science goals that require stars at fainter magnitudes than can be completely sampled by LAMOST. This algorithm has been implemented for the halo portion of the LAMOST pilot survey, which began in October 2011.", "doi": "10.1088/1674-4527/12/7/004", "issn": "1674-4527", "publisher": "IOP", "publication": "Research in Astronomy and Astrophysics", "publication_date": "2012-07", "series_number": "7", "volume": "12", "issue": "7", "pages": "755-771" }, { "id": "authors:m3hdk-v0958", "collection": "authors", "collection_id": "m3hdk-v0958", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20120831-125858377", "type": "article", "title": "LAMOST Experiment for Galactic Understanding and Exploration (LEGUE)\u2014 The survey's science plan", "author": [ { "family_name": "Deng", "given_name": "Li-Cai", "clpid": "Deng-Li-Cai" }, { "family_name": "Newberg", "given_name": "Heidi Jo", "clpid": "Newberg-H-J" }, { "family_name": "Liu", "given_name": "Chao", "orcid": "0000-0001-7049-493X", "clpid": "Liu-Chao" }, { "family_name": "Carlin", "given_name": "Jeffrey L.", "orcid": "0000-0002-3936-9628", "clpid": "Carlin-J-L" }, { "family_name": "Beers", "given_name": "Timothy C.", "orcid": "0000-0003-4573-6233", "clpid": "Beers-T-C" }, { "family_name": "Chen", "given_name": "Li", "clpid": "Chen-Li" }, { "family_name": "Chen", "given_name": "Yu-Qin", "clpid": "Chen-Yu-Qin" }, { "family_name": "Christlieb", "given_name": "Norbert", "orcid": "0000-0002-4043-2727", "clpid": "Christlieb-N" }, { "family_name": "Grillmair", "given_name": "Carl J.", "orcid": "0000-0003-4072-169X", "clpid": "Grillmair-C-J" }, { "family_name": "Guhathakurta", "given_name": "Puragra", "orcid": "0000-0001-8867-4234", "clpid": "Guhathakurta-P" }, { "family_name": "Han", "given_name": "Zhan-Wen", "clpid": "Han-Zhan-Wen" }, { "family_name": "Hou", "given_name": "Jin-Liang", "clpid": "Hou-Jin-Liang" }, { "family_name": "Lee", "given_name": "Hsu-Tai", "clpid": "Lee-Hsu-Tai" }, { "family_name": "L\u00e9pine", "given_name": "S\u00e9bastien", "orcid": "0000-0002-2437-2947", "clpid": "L\u00e9pine-S" }, { "family_name": "Li", "given_name": "Jing", "clpid": "Li-Jing" }, { "family_name": "Liu", "given_name": "Xiao-Wei", "clpid": "Liu-Xiao-Wei" }, { "family_name": "Pan", "given_name": "Kai-Ke", "clpid": "Pan-Kai-Ke" }, { "family_name": "Sellwood", "given_name": "J. A.", "clpid": "Sellwood-J-A" }, { "family_name": "Wang", "given_name": "Bo", "clpid": "Wang-Bo" }, { "family_name": "Wang", "given_name": "Hong-Chi", "clpid": "Wang-Hong-Chi" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Yanny", "given_name": "Brian", "orcid": "0000-0002-9541-2678", "clpid": "Yanny-Brian" }, { "family_name": "Zhang", "given_name": "Hao-Tong", "clpid": "Zhang-Hao-Tong" }, { "family_name": "Zhang", "given_name": "Yue-Yang", "clpid": "Zhang-Yue-Yang" }, { "family_name": "Zheng", "given_name": "Zheng", "clpid": "Zheng-Zheng" }, { "family_name": "Zhu", "given_name": "Zi", "clpid": "Zhu-Zi" } ], "abstract": "We describe the current plans for a spectroscopic survey of millions of stars in the Milky Way galaxy using the Guo Shou Jing Telescope (GSJT, formerly called the Large sky Area Multi-Object fiber Spectroscopic Telescope \u2014 LAMOST). The survey will obtain spectra for 2.5 million stars brighter than r < 19 during dark/grey time, and 5 million stars brighter than r < 17 or J < 16 on nights that are moonlit or have low transparency. The survey will begin in the fall of 2012, and will run for at least four years. The telescope's design constrains the optimal declination range for observations to 10\u00b0 < \u03b4 < 50\u00b0, and site conditions lead to an emphasis on stars in the direction of the Galactic anticenter. The survey is divided into three parts with different target selection strategies: disk, anticenter, and spheroid. The resulting dataset will be used to study the merger history of the Milky Way, the substructure and evolution of the disks, the nature of the first generation of stars through identification of the lowest metallicity stars, and star formation through study of open clusters and OB associations. Detailed design of the LAMOST Experiment for Galactic Understanding and Exploration (LEGUE) survey will be completed in summer 2012, after a review of the results of the pilot survey.", "doi": "10.1088/1674-4527/12/7/003", "issn": "1674-4527", "publisher": "IOP", "publication": "Research in Astronomy and Astrophysics", "publication_date": "2012-07", "series_number": "7", "volume": "12", "issue": "7", "pages": "735-754" }, { "id": "authors:04sz8-5p684", "collection": "authors", "collection_id": "04sz8-5p684", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20120724-095331294", "type": "article", "title": "Luminescence and decay kinetic mechanism of Pr^(3+) center in Lu_(0.8)Sc_(0.2)BO_3 host", "author": [ { "family_name": "Wu", "given_name": "Yuntao", "clpid": "Wu-Yuntao" }, { "family_name": "Jary", "given_name": "Vitezslav", "clpid": "Jary-Vitezslav" }, { "family_name": "Ren", "given_name": "Guohao", "clpid": "Ren-Guohao" }, { "family_name": "Nikl", "given_name": "Martin", "clpid": "Nikl-Martin" }, { "family_name": "Ding", "given_name": "Dongzhou", "clpid": "Ding-Dongzhou" }, { "family_name": "Pan", "given_name": "Shangke", "clpid": "Pan-Shangke" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" } ], "abstract": "The optical absorption, temperature dependence of emission spectra, prompt nanosecond decays and millisecond delayed recombination decays for Pr^(3+) center in Lu_(0.8)Sc_(0.2)BO_3 host were studied. The photoluminescence decay time decreases from 16 ns (80 K) to 11 ns (300 K), but its steady-state emission intensity at 300 K is stronger than that at 80 K and towards higher temperatures is further decreasing comparatively much less with respect to the decay time shortening, which was proved to be associated with the thermal ionization processes occurring from 5d_1 relaxed state of Pr^(3+). The quantitative parameters governing the ionization processes were calculated.", "doi": "10.1016/j.cplett.2012.05.010", "issn": "0009-2614", "publisher": "Elsevier", "publication": "Chemical Physics Letters", "publication_date": "2012-06-29", "volume": "539-540", "pages": "35-38" }, { "id": "authors:n3cs3-whz31", "collection": "authors", "collection_id": "n3cs3-whz31", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20130319-115145211", "type": "article", "title": "A Study on Radiation Damage in BGO and PWO-II Crystals", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Mao", "given_name": "Rihua", "clpid": "Mao-Rihua" }, { "family_name": "Zhang", "given_name": "Liyuan", "orcid": "0000-0002-0898-787X", "clpid": "Zhang-Liyuan" }, { "family_name": "Zhu", "given_name": "Ren-Yuan", "orcid": "0000-0003-3091-7461", "clpid": "Zhu-Ren-Yuan" } ], "abstract": "We report in this paper an investigation on radiation damage in 20 cm long BGO crystals produced at SIC as well as 20 cm long PWO-II crystals produced at BTCP for the proposed Panda experiment at GSI. The optical and scintillation properties of BGO and PWO-II crystals, such as transmittance, light output and light response uniformity, were measured before and after \u03b3-ray irradiations at different dose rates. BGO crystals produced recently are compared to crystals used in the L3 experiment at LEP which was produced in early eighties. PWO-II crystals are compared to crystals used in the CMS experiment. Progresses are observed in the radiation hardness for both crystals. Their use for crystal calorimeters in future high energy physics experiments is discussed. To maintain crystal precision, a precision light monitoring system is mandatory to trace variations of crystal transparency in situ for a BGO or PWO crystal calorimeter in radiation environment.", "doi": "10.1088/1742-6596/404/1/012025", "issn": "1742-6596", "publisher": "IOP", "publication": "Journal of Physics: Conference Series", "publication_date": "2012", "volume": "404", "pages": "Art. No. 012025" }, { "id": "authors:ecf2q-tra39", "collection": "authors", "collection_id": "ecf2q-tra39", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20110504-113210715", "type": "article", "title": "The Cancer/Testis Antigen Prostate-associated Gene 4\n (PAGE4) Is a Highly Intrinsically Disordered Protein", "author": [ { "family_name": "Zeng", "given_name": "Yu", "clpid": "Zeng-Yu" }, { "family_name": "He", "given_name": "Yanan", "clpid": "He-Yanan" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Mooney", "given_name": "Steven M.", "clpid": "Mooney-S-M" }, { "family_name": "Getzenberg", "given_name": "Robert H.", "clpid": "Getzenberg-R-H" }, { "family_name": "Orban", "given_name": "John", "clpid": "Orban-J" }, { "family_name": "Kulkarni", "given_name": "Prakash", "clpid": "Kulkarni-P" } ], "abstract": "The cancer/testis antigens (CTAs) are an important group of heterogeneous proteins that are predominantly expressed in the testis in the normal human adult but are aberrantly expressed in several types of cancers. Prostate-associated gene 4 (PAGE4) is a member of the CT-X family of CTAs that in addition to testis, is highly expressed in the fetal prostate, and may also play an important role both in benign and malignant prostate diseases. However, the function of this gene remains poorly understood. Here, we show that PAGE4 is a highly (100%) intrinsically disordered protein (IDP). The primary protein sequence conforms to the features of a typical IDP sequence and the secondary structure prediction algorithm metaPrDOS strongly supported this prediction. Furthermore, SDS-gel electrophoresis and analytical size exclusion chromatography of the recombinant protein revealed an anomalous behavior characteristic of IDPs. UV circular dichroism (CD) and NMR spectroscopy confirmed that PAGE4 is indeed a highly disordered protein. In further bioinformatic analysis, the PredictNLS algorithm uncovered a potential nuclear localization signal, whereas the algorithm DBS-Pred returned a 99.1% probability that PAGE4 is a DNA-binding protein. Consistent with this prediction, biochemical experiments showed that PAGE4 preferentially binds a GC-rich sequence. Silencing PAGE4 expression induced cell death via apoptosis and in mice carrying PCa xenografts, siRNA-mediated knockdown of the PAGE4 mRNA attenuated tumor growth in vivo. Furthermore, overexpressing PAGE4 protected cells from stress-induced death. To our knowledge, PAGE4 is the first example of a CTA that is an IDP with an anti-apoptotic function.", "doi": "10.1074/jbc.M110.210765", "pmcid": "PMC3077599", "issn": "0021-9258", "publisher": "American Society for Biochemistry and Molecular Biology", "publication": "Journal of Biological Chemistry", "publication_date": "2011-04-22", "series_number": "16", "volume": "286", "issue": "16", "pages": "13985-13994" }, { "id": "authors:2a2we-m4e40", "collection": "authors", "collection_id": "2a2we-m4e40", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20110421-161208459", "type": "article", "title": "Crystal structure of a hemojuvelin-binding fragment of neogenin at 1.8 \u00c5", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "West", "given_name": "Anthony P., Jr.", "clpid": "West-A-P-Jr" }, { "family_name": "Bjorkman", "given_name": "Pamela J.", "orcid": "0000-0002-2277-3990", "clpid": "Bjorkman-P-J" } ], "abstract": "Neogenin is a type I transmembrane glycoprotein with a large ectodomain containing tandem immunoglobulin-like and fibronectin type III (FNIII) domains. Closely related to the tumor suppressor gene DCC, neogenin functions in critical biological processes through binding to various ligands, including netrin, repulsive guidance molecules, and the iron regulatory protein hemojuvelin. We previously reported that neogenin binds to hemojuvelin through its membrane-proximal fifth and sixth FNIII domains (FN5\u20136), with domain 6 (FN6) contributing the majority of critical binding interactions. Here we present the crystal structure of FN5\u20136, the hemojuvelin-binding fragment of human neogenin, at 1.8 \u00c5. The two FNIII domains are orientated nearly linearly, a domain arrangement most similar to that of a tandem FNIII-containing fragment within the cytoplasmic tail of the \u03b24 integrin. By mapping surface-exposed residues that differ between neogenin FN5\u20136 and the comparable domains from DCC, which does not bind hemojuvelin, we identified a potential hemojuvelin-binding site on neogenin FN6. Neogenin FN5, which does not bind hemojuvelin in isolation, exhibits a highly electropositive surface, which may be involved in interactions with negatively-charged polysaccharides or phospholipids in the membrane bilayer. The neogenin FN5\u20136 structure can be used to facilitate a molecular understanding of neogenin's interaction with hemojuvelin to regulate iron homeostasis and with hemojuvelin-related repulsive guidance molecules to mediate axon guidance.", "doi": "10.1016/j.jsb.2010.10.005", "pmcid": "PMC3074981", "issn": "1047-8477", "publisher": "Elsevier", "publication": "Journal of Structural Biology", "publication_date": "2011-04", "series_number": "1", "volume": "174", "issue": "1", "pages": "239-244" }, { "id": "authors:d6hdh-ns640", "collection": "authors", "collection_id": "d6hdh-ns640", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20110302-114003661", "type": "article", "title": "Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein", "author": [ { "family_name": "Zhang", "given_name": "An-Sheng", "clpid": "Zhang-An-Sheng" }, { "family_name": "Anderson", "given_name": "Sheila A.", "clpid": "Anderson-S-A" }, { "family_name": "Wang", "given_name": "Jiaohong", "clpid": "Wang-Jiaohong" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "DeMaster", "given_name": "Kristina", "clpid": "DeMaster-K" }, { "family_name": "Ahmed", "given_name": "Riffat", "clpid": "Ahmed-R" }, { "family_name": "Nizzi", "given_name": "Christopher P.", "clpid": "Nizzi-C-P" }, { "family_name": "Eisenstein", "given_name": "Richard S.", "clpid": "Eisenstein-R-S" }, { "family_name": "Tsukamoto", "given_name": "Hidekazu", "clpid": "Tsukamoto-H" }, { "family_name": "Enns", "given_name": "Caroline A.", "clpid": "Enns-C-A" } ], "abstract": "Recent studies demonstrate a pivotal role for bone morphogenic protein-6 (BMP6) and matriptase-2, a protein encoded by the TMPRSS6 gene, in the induction and suppression of hepatic hepcidin expression, respectively. We examined their expression profiles in the liver and showed a predominant localization of BMP6 mRNA in nonparenchymal cells and exclusive expression of TMPRSS6 mRNA in hepatocytes. In rats fed an iron-deficient (ID) diet for 24 hours, the rapid decrease of transferrin saturation from 71% to 24% (control vs ID diet) was associated with a 100-fold decrease in hepcidin mRNA compared with the corresponding controls. These results indicated a close correlation of low transferrin saturation with decreased hepcidin mRNA. The lower phosphorylated Smad1/5/8 detected in the ID rat livers suggests that the suppressed hepcidin expression results from the inhibition of BMP signaling. Quantitative real-time reverse transcription polymerase chain reaction analysis revealed no significant change in either BMP6 or TMPRSS6 mRNA in the liver. However, an increase in matriptase-2 protein in the liver from ID rats was detected, suggesting that suppression of hepcidin expression in response to acute iron deprivation is mediated by an increase in matriptase-2 protein levels.", "doi": "10.1182/blood-2010-06-287292", "issn": "0006-4971", "publisher": "American Society of Hematology", "publication": "Blood", "publication_date": "2011-02-03", "series_number": "5", "volume": "117", "issue": "5", "pages": "1687-1699" }, { "id": "authors:9tqnw-a5194", "collection": "authors", "collection_id": "9tqnw-a5194", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20100908-113300905", "type": "article", "title": "Effective thermal conductivity of polycrystalline materials with randomly oriented superlattice grains", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Ikeda", "given_name": "Teruyuki", "orcid": "0000-0001-7076-6958", "clpid": "Ikeda-Teruyuki" }, { "family_name": "Snyder", "given_name": "G. Jeffrey", "orcid": "0000-0003-1414-8682", "clpid": "Snyder-G-J" }, { "family_name": "Dames", "given_name": "Chris", "clpid": "Dames-C" } ], "abstract": "A model has been established for the effective thermal conductivity of a bulk polycrystal made of randomly oriented superlattice grains with anisotropic thermal conductivity. The in-plane and cross-plane thermal conductivities of each superlattice grain are combined using an analytical averaging rule that is verified using finite element methods. The superlattice conductivities are calculated using frequency dependent solutions of the Boltzmann transport equation, which capture greater thermal conductivity reductions as compared to the simpler gray medium approximation. The model is applied to a PbTe/Sb_2Te_3 nanobulk material to investigate the effects of period, specularity, and temperature. The calculations show that the effective thermal conductivity of the polycrystal is most sensitive to the in-plane conductivity of each superlattice grain, which is generally four to five times larger than the cross-plane conductivity of a grain. The model is compared to experimental measurements of the same system for periods ranging from 287 to 1590 nm and temperatures from 300 to 500 K. The comparison suggests that the effective specularity increases with increasing annealing temperature and shows that these samples are in a mixed regime where both Umklapp and boundary scattering are important.", "doi": "10.1063/1.3457334", "issn": "0021-8979", "publisher": "American Institute of Physics", "publication": "Journal of Applied Physics", "publication_date": "2010-08-01", "series_number": "3", "volume": "108", "issue": "3", "pages": "034310" }, { "id": "authors:hmp0h-ctx52", "collection": "authors", "collection_id": "hmp0h-ctx52", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20090828-231034697", "type": "article", "title": "Hemojuvelin-Neogenin Interaction Is Required for Bone Morphogenic Protein-4-induced Hepcidin Expression", "author": [ { "family_name": "Zhang", "given_name": "An-Sheng", "clpid": "Zhang-An-Sheng" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Wang", "given_name": "Jiaohong", "clpid": "Wang-Jiaohong" }, { "family_name": "Tsukamoto", "given_name": "Hidekazu", "clpid": "Tsukamoto-Hidekazu" }, { "family_name": "Enns", "given_name": "Caroline A.", "clpid": "Enns-C-A" } ], "abstract": "Hemojuvelin (HJV) is a glycosylphosphatidylinositol-linked protein and binds both bone morphogenic proteins (BMPs) and neogenin. Cellular HJV acts as a BMP co-receptor to enhance the transcription of hepcidin, a key iron regulatory hormone secreted predominantly by liver hepatocytes. In this study we characterized the role of neogenin in HJV-regulated hepcidin expression. Both HJV and neogenin were expressed in liver hepatocytes. Knockdown of neogenin decreased BMP4-induced hepcidin mRNA levels by 16-fold in HJV-expressing HepG2 cells but only by about 2-fold in cells transfected with either empty vector or G99V mutant HJV that does not bind BMPs. Further studies indicated that disruption of the HJV-neogenin interaction is responsible for a marked suppression of hepcidin expression. Moreover, in vivo studies showed that hepatic hepcidin mRNA could be significantly suppressed by blocking the interaction of HJV with full-length neogenin with a soluble fragment of neogenin in mice. Together, these results suggest that the HJV-neogenin interaction is required for the BMP-mediated induction of hepcidin expression when HJV is expressed. Combined with our previous studies, our results support that hepatic neogenin possesses two functions, mediation of cellular HJV release, and stimulation of HJV-enhanced hepcidin expression.", "doi": "10.1074/jbc.M109.027318", "pmcid": "PMC2755665", "issn": "0021-9258", "publisher": "American Society for Biochemistry and Molecular Biology", "publication": "Journal of Biological Chemistry", "publication_date": "2009-08-21", "series_number": "34", "volume": "284", "issue": "34", "pages": "22580-22589" }, { "id": "authors:qnn05-yfp83", "collection": "authors", "collection_id": "qnn05-yfp83", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:ZHAjbc08", "type": "article", "title": "Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plamsa membrane", "author": [ { "family_name": "Zhang", "given_name": "An-Sheng", "clpid": "Zhang-An-Sheng" }, { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Meyer", "given_name": "Kathrin", "clpid": "Meyer-K" }, { "family_name": "Hernandez", "given_name": "Catalina", "clpid": "Hernandez-C" }, { "family_name": "Chapman-Arvedson", "given_name": "Tara", "clpid": "Chapman-Arvedson-T" }, { "family_name": "Bjorkman", "given_name": "Pamela J.", "orcid": "0000-0002-2277-3990", "clpid": "Bjorkman-P-J" }, { "family_name": "Enns", "given_name": "Caroline A.", "clpid": "Enns-C-A" } ], "abstract": "Hemochromatosis type 2 gene (HFE2) is highly expressed in skeletal muscle and liver hepatocytes. Its encoded protein, hemojuvelin (HJV), is a co-receptor for the bone morphogenetic proteins 2 and 4 (BMP2 and BMP4) and enhances the BMP-induced hepcidin expression. Hepcidin is a central iron regulatory hormone predominantly secreted from hepatocytes. HJV also binds neogenin, a membrane protein widely expressed in many tissues. Neogenin is required for the processing and release of HJV from cells. The role that neogenin plays in HJV trafficking was investigated, using HepG2 cells, a human hepatoma cell line. Knockdown of endogenous neogenin markedly suppresses HJV release, but has no evident effect on HJV trafficking to the plasma membrane. Addition of a soluble neogenin ectodomain to cells markedly inhibits HJV release, indicating that the HJV shedding is not processed before trafficking to the cell surface. At the plasma membrane it undergoes endocytosis in a dynamin-independent but cholesterol-dependent manner. The additional findings that HJV release is coupled to lysosomal degradation of neogenin, that HJV undergoes endocytosis, and that cholesterol depletion by filipin blocks both HJV endocytosis and HJV release, suggest that neogenin-mediated HJV release occurs after the HJV-neogenin complex is internalized from the cell surface.", "doi": "10.1074/jbc.M710527200", "pmcid": "PMC2427329", "issn": "0021-9258", "publisher": "American Society for Biochemistry and Molecular Biology", "publication": "Journal of Biological Chemistry", "publication_date": "2008-06-20", "series_number": "25", "volume": "283", "issue": "25", "pages": "17494-17502" }, { "id": "authors:jcynj-ts359", "collection": "authors", "collection_id": "jcynj-ts359", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20170201-074623072", "type": "article", "title": "Neogenin Interacts with Hemojuvelin through Its Two Membrane-Proximal Fibronectin Type III Domains", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "West", "given_name": "Anthony P.", "clpid": "West-A-P-Jr" }, { "family_name": "Allendorph", "given_name": "George P.", "clpid": "Allendorph-G-P" }, { "family_name": "Choe", "given_name": "Senyon", "clpid": "Choe-Senyon" }, { "family_name": "Bjorkman", "given_name": "Pamela J.", "orcid": "0000-0002-2277-3990", "clpid": "Bjorkman-P-J" } ], "abstract": "Hemojuvelin is a recently identified iron-regulatory protein that plays an important role in affecting the expression of hepcidin, a key iron regulatory hormone. Although the underlying mechanism of this process is not clear, several hemojuvelin-binding proteins, including the cell surface receptor neogenin and bone morphogenetic protein (BMP) cytokines, have been identified. The ectodomain of neogenin is composed of four immunoglobulin-like (Ig) domains followed by six fibronectin type III-like (FNIII) domains. Here we report expression of soluble versions of hemojuvelin and neogenin for biochemical characterization of their interaction and the interaction of HJV with BMP-2. Hemojuvelin normally undergoes an autocatalytic cleavage, and as in vivo, recombinant hemojuvelin exists as a mixture of cleaved and uncleaved forms. Neogenin binds to cleaved and noncleaved hemojuvelin, as verified by its binding to an uncleaved mutant hemojuvelin. We localized the hemojuvelin binding site on neogenin to the membrane-proximal fifth and sixth FNIII domains and the juxtamembrane linker and showed that a fragment containing only this region binds 2\u20133 orders of magnitude more tightly than the entire neogenin ectodomain. Binding to the most membrane-proximal region of neogenin may play a role in regulating the levels of soluble and membrane-bound forms of hemojuvelin, which in turn would influence the amount of free BMP-2 available for binding to its receptors and triggering transcription of the hepcidin gene. Our finding that BMP-2 and neogenin bind simultaneously to hemojuvelin raises the possibility that neogenin is part of a multiprotein complex at the hepatocyte membrane involving BMP, its receptors, and hemojuvelin.", "doi": "10.1021/bi800036h", "pmcid": "PMC2819367", "issn": "0006-2960", "publisher": "American Chemical Society", "publication": "Biochemistry", "publication_date": "2008-04-08", "series_number": "14", "volume": "47", "issue": "14", "pages": "4237-4245" }, { "id": "authors:veg5y-g5b64", "collection": "authors", "collection_id": "veg5y-g5b64", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20160510-080154263", "type": "article", "title": "Inhibition of Moloney murine leukemia virus integration using polyamides targeting the long-terminal repeat sequences", "author": [ { "family_name": "Yang", "given_name": "Fan", "clpid": "Yang-Fan" }, { "family_name": "Belitsky", "given_name": "Jason M.", "clpid": "Belitsky-J-M" }, { "family_name": "Villanueva", "given_name": "Rodrigo A.", "clpid": "Villanueva-R-A" }, { "family_name": "Dervan", "given_name": "Peter B.", "orcid": "0000-0001-8852-7306", "clpid": "Dervan-P-B" }, { "family_name": "Roth", "given_name": "Monica J.", "clpid": "Roth-M-J" } ], "abstract": "The retroviral integrase (IN) carries out the integration of the viral DNA into the host genome. Both IN and the DNA sequences at the viral long-terminal repeat (LTR) are required for the integration function. In this report, a series of minor groove binding hairpin polyamides targeting sequences within terminal inverted repeats of the Moloney murine leukemia virus (M-MuLV) LTR were synthesized, and their effects on integration were analyzed. Using cell-free in vitro integration assays, polyamides targeting the conserved CA dinucleotide with cognate sites closest to the terminal base pairs were effective at blocking 3' processing but not strand transfer. Polyamides which efficiently inhibited 3' processing and strand transfer targeted the LTR sequences through position 9. Polyamides that inhibited integration were effective at nanomolar concentrations and showed subnanomolar affinity for their cognate LTR sites. These studies highlight the role of minor groove interactions within the LTR termini for retroviral integration.", "doi": "10.1021/bi034177s", "issn": "0006-2960", "publisher": "American Chemical Society", "publication": "Biochemistry", "publication_date": "2003-05-27", "series_number": "20", "volume": "42", "issue": "20", "pages": "6249-6258" } ]