[ { "id": "https://authors.library.caltech.edu/records/s9w0g-9d298", "eprint_id": 89026, "eprint_status": "archive", "datestamp": "2023-08-19 10:45:01", "lastmod": "2023-10-18 22:27:55", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Houk-K-N", "name": { "family": "Houk", "given": "K. N." }, "orcid": "0000-0002-8387-5261" }, { "id": "Caserio-M-C", "name": { "family": "Caserio", "given": "Marjorie C." } }, { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" }, { "id": "Schuster-D-I", "name": { "family": "Schuster", "given": "David I." }, "orcid": "0000-0002-8989-1801" }, { "id": "Dervan-P-B", "name": { "family": "Dervan", "given": "Peter B." }, "orcid": "0000-0001-8852-7306" }, { "id": "Dougherty-D-A", "name": { "family": "Dougherty", "given": "Dennis A." }, "orcid": "0000-0003-1464-2461" } ] }, "title": "J. D. Roberts Special Issue", "ispublished": "pub", "full_text_status": "public", "note": "\u00a9 2018 John Wiley & Sons, Ltd. \n\nIssue Online: 26 July 2018; Version of Record online: 05 July 2018. \n\nSpecial Issue: Special issue dedicated to Jack Roberts on the occasion of his 100th birthday.", "abstract": "[no abstract]", "date": "2018-08", "date_type": "published", "publication": "Journal of Physical Organic Chemistry", "volume": "31", "number": "8", "publisher": "Wiley", "pagerange": "Art. No. e3886", "id_number": "CaltechAUTHORS:20180822-110902834", "issn": "0894-3230", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180822-110902834", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "doi": "10.1002/poc.3886", "resource_type": "article", "pub_year": "2018", "author_list": "Houk, K. N.; Caserio, Marjorie C.; et el." }, { "id": "https://authors.library.caltech.edu/records/58ar3-35k81", "eprint_id": 16089, "eprint_status": "archive", "datestamp": "2023-08-19 00:16:56", "lastmod": "2023-10-19 21:57:48", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Tang-Sindy-K-Y", "name": { "family": "Tang", "given": "Sindy K. Y." } }, { "id": "Li-Zhenyu", "name": { "family": "Li", "given": "Zhenyu" } }, { "id": "Abate-Adam-R", "name": { "family": "Abate", "given": "Adam R." }, "orcid": "0000-0001-9614-4831" }, { "id": "Agresti-J-J", "name": { "family": "Agresti", "given": "Jeremy J." } }, { "id": "Weitz-D-A", "name": { "family": "Weitz", "given": "David A." } }, { "id": "Psaltis-D", "name": { "family": "Psaltis", "given": "Demetri" } }, { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" } ] }, "title": "A multi-color fast-switching microfluidic droplet dye laser", "ispublished": "pub", "full_text_status": "public", "note": "This journal is \u00a9 The Royal Society of Chemistry 2009. \n\nReceived 14th July 2009, Accepted 10th August 2009. First published as an Advance Article on the web 14th August 2009. \n\nThis work was funded in part by DARPA award number W911NF-07-10647, and the Center for Optofluidic Integration at Caltech under award HR011-04-1-0032 from DARPA. A portion of this work was supported by the Micro/Nano Fluidics Fundamentals Focus (MF3) Center at the University of California, Irvine. We thank Dr. Brian Hutchison, and Dr. Darren Link from Raindance Technologies for the supply of the fluorosurfactant. We also thank Drs Claudiu Stan, Ratmir Derda, Michinao Hashimoto, and Coskun Kocabas for helpful discussions. \n\nElectronic supplementary information (ESI) available: Fig. S1, Fig. S2 and a discussion about lasing modes. See DOI: 10.1039/b914066b\n\n
Published - Tang2009p6007Lab_on_a_Chip.pdf
Supplemental Material - b914066b.pdf
", "abstract": "We describe a multi-color microfluidic dye laser operating in whispering gallery mode based on a train of alternating droplets containing solutions of different dyes; this laser is capable of switching the wavelength of its emission between 580 nm and 680 nm at frequencies up to 3.6 kHz -\u2014 the fastest among all dye lasers reported; it has potential applications in on-chip spectroscopy and flow cytometry.", "date": "2009-10-07", "date_type": "published", "publication": "Lab on a Chip", "volume": "9", "number": "19", "publisher": "Royal Society of Chemistry", "pagerange": "2767-2771", "id_number": "CaltechAUTHORS:20090928-140823265", "issn": "1473-0197", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20090928-140823265", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Defense Advanced Research Projects Agency (DARPA)", "grant_number": "W911NF-07-10647" }, { "agency": "Defense Advanced Research Projects Agency (DARPA)", "grant_number": "HR011-04-1-0032" }, { "agency": "University of California, Irvine" } ] }, "doi": "10.1039/b914066b", "primary_object": { "basename": "Tang2009p6007Lab_on_a_Chip.pdf", "url": "https://authors.library.caltech.edu/records/58ar3-35k81/files/Tang2009p6007Lab_on_a_Chip.pdf" }, "related_objects": [ { "basename": "b914066b.pdf", "url": "https://authors.library.caltech.edu/records/58ar3-35k81/files/b914066b.pdf" } ], "resource_type": "article", "pub_year": "2009", "author_list": "Tang, Sindy K. Y.; Li, Zhenyu; et el." }, { "id": "https://authors.library.caltech.edu/records/6gnkw-hmq18", "eprint_id": 40875, "eprint_status": "archive", "datestamp": "2023-08-22 00:30:06", "lastmod": "2023-10-24 22:32:18", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Stroock-A-D", "name": { "family": "Stroock", "given": "Abraham D." } }, { "id": "Ismagilov-R-F", "name": { "family": "Ismagilov", "given": "Rustem F." }, "orcid": "0000-0002-3680-4399" }, { "id": "Stone-H-A", "name": { "family": "Stone", "given": "Howard A." } }, { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" } ] }, "title": "Fluidic Ratchet Based on Marangoni\u2212B\u00e9nard Convection", "ispublished": "pub", "full_text_status": "restricted", "keywords": "instability; equilibrium; competition", "note": "Copyright \u00a9 2003 American Chemical Society. \n\nPublished In Issue: May 13, 2003. Received August 12, 2002. Revised February 24, 2003. \n\nThe work in the laboratory of G.M.W. was supported by the Department of Energy (DE-FG02-OOER45852). The work of both G.M.W. and H.A.S. was supported by NSF MRSEC DMR-9809363 and DARPA.", "abstract": "A mean flow is observed experimentally in a layer of fluid undergoing Marangoni-Benard convection over a heated substrate that presents a pattern of asymmetrical grooves. The direction of the mean flow is a function of the temperature difference across the layer and of the thickness of the layer; the direction can be controlled by changing these parameters. This system acts as a fluidic ratchet: the local structure of the thermally driven convection interacts with the asymmetry of the local topographical pattern and causes a net, global flow in the fluid. This fluidic ratchet may be useful in handling fluids on macroscopic and microscopic scales.", "date": "2003-05-13", "date_type": "published", "publication": "Langmuir", "volume": "19", "number": "10", "publisher": "American Chemical Society", "pagerange": "4358-4362", "id_number": "CaltechAUTHORS:20130821-160732896", "issn": "0743-7463", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20130821-160732896", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Department of Energy (DOE)", "grant_number": "DE-FG02-OOER45852" }, { "agency": "NSF", "grant_number": "DMR-9809363" }, { "agency": "DARPA" } ] }, "doi": "10.1021/la026400c", "resource_type": "article", "pub_year": "2003", "author_list": "Stroock, Abraham D.; Ismagilov, Rustem F.; et el." }, { "id": "https://authors.library.caltech.edu/records/hpe9w-e2462", "eprint_id": 40803, "eprint_status": "archive", "datestamp": "2023-08-21 23:03:22", "lastmod": "2023-10-24 22:00:32", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Ismagilov-R-F", "name": { "family": "Ismagilov", "given": "Rustem F." }, "orcid": "0000-0002-3680-4399" }, { "id": "Schwartz-A", "name": { "family": "Schwartz", "given": "Alexander" } }, { "id": "Bowden-N", "name": { "family": "Bowden", "given": "Ned" } }, { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" } ] }, "title": "Autonomous movement and self-assembly", "ispublished": "pub", "full_text_status": "restricted", "keywords": "microfluidic systems; molecular motors; polymer gels; motion; complexity; patterns; water; atp", "note": "\u00a9 2002 WILEY-VCH. \n\nIssue published online: 14 FEB 2002. Article first published online: 14 FEB 2002. Manuscript Received: 22 NOV 2001 .\n\nThis work was supported by DoE under grant 00ER45852. The salary of R.F.I. was provided by the DARPA and NSF under grant NSF ECS-9729405; the salary of A.S. was provided by the NSF under grant NSF CHE-9901358.", "abstract": "The artificial millimeter-scale \"autonomous movers\" glide across the surface of a liquid without an external power source. This system is based on a combination of two processes: Motion of individual objects powered by the catalytic decomposition of hydrogen peroxide, and relative motion (self-assembly) caused by capillary interactions at the fluid/air interface. The picture shows the rotational/translational motion of a single object; the motion of a pair of these object depends on their chirality.", "date": "2002-02-15", "date_type": "published", "publication": "Angewandte Chemie International Edition", "volume": "41", "number": "4", "publisher": "Wiley", "pagerange": "652-654", "id_number": "CaltechAUTHORS:20130821-160720419", "issn": "1433-7851", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20130821-160720419", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Department of Energy (DOE)", "grant_number": "00ER45852" }, { "agency": "DARPA" }, { "agency": "NSF", "grant_number": "ECS-9729405" }, { "agency": "NSF", "grant_number": "CHE-9901358" } ] }, "doi": "10.1002/1521-3773(20020215)41:4<652::AID-ANIE652>3.0.CO;2-U", "resource_type": "article", "pub_year": "2002", "author_list": "Ismagilov, Rustem F.; Schwartz, Alexander; et el." }, { "id": "https://authors.library.caltech.edu/records/fmpcf-bej39", "eprint_id": 40800, "eprint_status": "archive", "datestamp": "2023-08-21 22:42:08", "lastmod": "2023-10-24 22:00:19", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Ismagilov-R-F", "name": { "family": "Ismagilov", "given": "Rustem F." }, "orcid": "0000-0002-3680-4399" }, { "id": "Ng-Jessamine-M-K", "name": { "family": "Ng", "given": "Jessamine M. K." } }, { "id": "Kenis-P-J-A", "name": { "family": "Kenis", "given": "Paul J. A." } }, { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" } ] }, "title": "Microfluidic arrays of fluid-fluid diffusional contacts as detection elements and combinatorial tools", "ispublished": "pub", "full_text_status": "restricted", "keywords": "western blots; proteins; systems; fabrication; cells; flows; pdms", "note": "Copyright \u00a9 2001 American Chemical Society. \n\nPublished In Issue: November 01, 2001. Received for review May 2, 2001. Accepted July 24, 2001.\n\nThis work was supported by DARPA and NSF (ECS-0004030). We thank Steve Metallo (Harvard University) for helpful discussions.", "abstract": "This paper describes microfluidic systems that can be used to investigate multiple chemical or biochemical interactions in a parallel format. These three-dimensional systems are generated by crossing two sets of microfluidic channels, fabricated in two different layers, at tight angles. Solutions of the reagents are placed in the channels; in different modes of operation, these solutions can be either flowing or stationary- the latter is important when one set of channels is filled with viscous gels with immobilized reagents. At every crossing, the channels are separated either by a single membrane or by a composite separator comprising a membrane, a microwell, and a second membrane. These components allow diffusive mass transport and minimize convective transport through the crossing. Polycarbonate membranes with 0.1-1-mum vertical pores were used to fabricate the devices. Each crossing of parallel channels serves as an element in which chemical or biochemical interactions can take place; interactions can be detected by monitoring changes in fluorescence and absorbance. These all- organic systems are straightforward to fabricate and to operate and may find applications as portable microanalytical systems and as tools in combinatorial research.", "date": "2001-11-01", "date_type": "published", "publication": "Analytical Chemistry", "volume": "73", "number": "21", "publisher": "American Chemical Society", "pagerange": "5207-5213", "id_number": "CaltechAUTHORS:20130821-160719890", "issn": "0003-2700", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20130821-160719890", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "DARPA" }, { "agency": "NSF", "grant_number": "ECS-0004030" } ] }, "doi": "10.1021/ac010502a", "resource_type": "article", "pub_year": "2001", "author_list": "Ismagilov, Rustem F.; Ng, Jessamine M. K.; et el." }, { "id": "https://authors.library.caltech.edu/records/warvr-y6x22", "eprint_id": 40802, "eprint_status": "archive", "datestamp": "2023-08-21 22:36:54", "lastmod": "2023-10-24 22:00:30", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Ismagilov-R-F", "name": { "family": "Ismagilov", "given": "Rustem F." }, "orcid": "0000-0002-3680-4399" }, { "id": "Rosmarin-D", "name": { "family": "Rosmarin", "given": "David" } }, { "id": "Kenis-P-J-A", "name": { "family": "Kenis", "given": "Paul J. A." } }, { "id": "Chiu-Daniel-T", "name": { "family": "Chiu", "given": "Daniel T." } }, { "id": "Zhang-Wendy", "name": { "family": "Zhang", "given": "Wendy" } }, { "id": "Stone-H-A", "name": { "family": "Stone", "given": "Howard A." } }, { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" } ] }, "title": "Pressure-driven laminar flow in tangential microchannels: an elastomeric microfluidic switch", "ispublished": "pub", "full_text_status": "restricted", "keywords": "systems; fabrication; poly(dimethylsiloxane); networks; pdms", "note": "Copyright \u00a9 2001 American Chemical Society. \n\nPublished In Issue: October 01, 2001. Received for review April 2, 2001. Accepted July 8, 2001. \n\nThis work was supported by DARPA and NSF ECS-0004030 and ECS-9729405. We thank Jacqueline Ashmore (Harvard) for helpful discussions.", "abstract": "This paper describes laminar fluid flow through a three- dimensional elastomeric microstructure formed by two microfluidic channels, fabricated in layers that contact one another face-to-face (typically at a 90 degrees angle), with the fluid flows in tangential contact. There are two ways to control fluid flow through these tangentially connected microchannels. First, the flow profiles through the crossings are sensitive to the aspect ratio of the channels; the flow can be controlled by applying external pressure and changing this aspect ratio. Second, the flow direction of an individual laminar stream in multiphase laminar flow depends on the lateral position of the stream within the channel; this position can be controlled by injecting additional streams of fluid into the channel. We describe two microfluidic switches based on these two ways for controlling fluid flow through tangential microchannels and present theoretical arguments that explain the observed dependence of the flow profiles on the aspect ratio of the channels.", "date": "2001-10-01", "date_type": "published", "publication": "Analytical Chemistry", "volume": "73", "number": "19", "publisher": "American Chemical Society", "pagerange": "4682-4687", "id_number": "CaltechAUTHORS:20130821-160720235", "issn": "0003-2700", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20130821-160720235", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "DARPA" }, { "agency": "NSF", "grant_number": "ECS-0004030" }, { "agency": "NSF", "grant_number": "ECS-9729405" } ] }, "doi": "10.1021/ac010374q", "resource_type": "article", "pub_year": "2001", "author_list": "Ismagilov, Rustem F.; Rosmarin, David; et el." }, { "id": "https://authors.library.caltech.edu/records/2vtmg-1y153", "eprint_id": 40801, "eprint_status": "archive", "datestamp": "2023-08-21 22:26:41", "lastmod": "2023-10-24 22:00:24", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Ismagilov-R-F", "name": { "family": "Ismagilov", "given": "Rustem F." }, "orcid": "0000-0002-3680-4399" }, { "id": "Rosmarin-D", "name": { "family": "Rosmarin", "given": "David" } }, { "id": "Gracias-D-H", "name": { "family": "Gracias", "given": "David H." } }, { "id": "Stroock-A-D", "name": { "family": "Stroock", "given": "Abraham D." } }, { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" } ] }, "title": "Competition of intrinsic and topographically imposed patterns in Benard-Marangoni convection", "ispublished": "pub", "full_text_status": "public", "keywords": "commensurate; equilibrium; systems; layers; Benard convection, flow visualisation, infrared imaging, periodic structures", "note": "\u00a9 2001 American Institute of Physics. \n\n(Received 15 March 2001; accepted 18 May 2001) \n\nThis work was supported by DoE under Grant No. 00ER45852. The authors thank Howard Stone (Harvard) for many valuable discussions, and Allen Frechette and Kellie Reardon (FLIR Systems), and John Boucher (Harvard University) for technical assistance with IR imaging and for providing the IR camera used in this work.\n\nPublished - ApplPhysLett_79_439.pdf
", "abstract": "The structure of Benard-Marangoni convection cells can be controlled by periodic topographic patterns on the heated surface that generates the convection. When the periodicity of the topographic pattern matches the intrinsic periodicity of the convection cells, a convective pattern is formed that is 1:1 commensurate with the topographic pattern. Arrays of hexagonal, square, and triangular convection cells were generated over the appropriately designed topographic patterns, and visualized by infrared imaging. For imposed patterns with periodicity in two dimensions, as the ratio of the intrinsic and perturbing length scales changes, the pattern of the convection cells shows sharp transitions between different patterns commensurate with the imposed pattern. For imposed patterns with periodicity in one dimension (i.e., lines) the convection cells use the unconstrained dimension to adapt continuously to the external perturbation. Topographically controlled convection cells can be used to assemble microscopic particles into externally switchable regular lattices. (C) 2001 American Institute of Physics.", "date": "2001-07-16", "date_type": "published", "publication": "Applied Physics Letters", "volume": "79", "number": "3", "publisher": "American Institute of Physics", "pagerange": "439-441", "id_number": "CaltechAUTHORS:20130821-160720076", "issn": "0003-6951", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20130821-160720076", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Department of Energy (DOE)", "grant_number": "00ER45852" } ] }, "doi": "10.1063/1.1384473", "primary_object": { "basename": "ApplPhysLett_79_439.pdf", "url": "https://authors.library.caltech.edu/records/2vtmg-1y153/files/ApplPhysLett_79_439.pdf" }, "resource_type": "article", "pub_year": "2001", "author_list": "Ismagilov, Rustem F.; Rosmarin, David; et el." }, { "id": "https://authors.library.caltech.edu/records/b1ede-7p147", "eprint_id": 40794, "eprint_status": "archive", "datestamp": "2023-08-21 22:20:44", "lastmod": "2023-10-24 21:59:53", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Holmlin-R-E", "name": { "family": "Holmlin", "given": "R. Erik" } }, { "id": "Ismagilov-R-F", "name": { "family": "Ismagilov", "given": "Rustem F." }, "orcid": "0000-0002-3680-4399" }, { "id": "Haag-R", "name": { "family": "Haag", "given": "Rainer" } }, { "id": "Mujica-V", "name": { "family": "Mujica", "given": "Vladimiro" } }, { "id": "Ratner-M-A", "name": { "family": "Ratner", "given": "Mark A." } }, { "id": "Rampi-M-A", "name": { "family": "Rampi", "given": "Maria Anita" } }, { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" } ] }, "title": "Correlating electron transport and molecular structure in organic thin films", "ispublished": "pub", "full_text_status": "restricted", "keywords": "electron transfer; monolayers; self assembly; thin films self-assembled monolayers; alkanethiol monolayers; gold; conductance; spectra; bond", "note": "\u00a9 2001 WILEY-VCH. \n\nArticle first published online: 13 JUN 2001.\n\nThis work was supported by the Office of Naval Research, the Defense Advanced Research Project Agency, and the National Science Foundation ECS-97294053. R.E.H. thanks the National Institutes of Health for a postdoctoral fellowship, and R.H. thanks the Deutsche Forschungsgemeinschaft and the BASF fellowship program for financial support. We thank Andreas Terfort for the synthesis of aromatic thiols. Collaboration between Caracas and Evanston is supported by NSF Conicit.", "abstract": "A convenient experimental system is described, with which electron transport through structurally well-defined, 2\u20135 nm-thick, organic films can be examined. Two types of junction J have been studied in which self-assembled monolayers (SAMs, for example, SAM(1) formed on Ag from aliphatic and aromatic thiols, and SAM(2), formed on Hg from hexadecanethiol) are in contact through either van der Waals interactions (see picture) or through covalent, hydrogen, or ionic bonds.", "date": "2001-06-18", "date_type": "published", "publication": "Angewandte Chemie International Edition", "volume": "40", "number": "12", "publisher": "Wiley", "pagerange": "2316-2320", "id_number": "CaltechAUTHORS:20130821-160718857", "issn": "1433-7851", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20130821-160718857", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Office of Naval Research (ONR)" }, { "agency": "Defense Advanced Research Projects Agency (DARPA)" }, { "agency": "NSF", "grant_number": "ECS-97294053" }, { "agency": "NIH" }, { "agency": "Deutsche Forschungsgemeinschaft (DFG)" }, { "agency": "BASF" }, { "agency": "NSF Conicit" } ] }, "doi": "10.1002/1521-3773(20010618)40:12<2316::AID-ANIE2316>3.0.CO;2-#", "resource_type": "article", "pub_year": "2001", "author_list": "Holmlin, R. Erik; Ismagilov, Rustem F.; et el." }, { "id": "https://authors.library.caltech.edu/records/wwktg-f5w34", "eprint_id": 40793, "eprint_status": "archive", "datestamp": "2023-08-21 22:16:26", "lastmod": "2023-10-23 15:51:39", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Holmlin-R-E", "name": { "family": "Holmlin", "given": "R. Erik" } }, { "id": "Haag-R", "name": { "family": "Haag", "given": "Rainer" } }, { "id": "Chabinyc-M-L", "name": { "family": "Chabinyc", "given": "Michael L." }, "orcid": "0000-0003-4641-3508" }, { "id": "Ismagilov-R-F", "name": { "family": "Ismagilov", "given": "Rustem F." }, "orcid": "0000-0002-3680-4399" }, { "id": "Cohen-A-E", "name": { "family": "Cohen", "given": "Adam E." } }, { "id": "Terfort-A", "name": { "family": "Terfort", "given": "Andreas" } }, { "id": "Rampi-M-A", "name": { "family": "Rampi", "given": "Maria Anita" } }, { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" } ] }, "title": "Electron transport through thin organic films in metal- insulator-metal junctions based on self-assembled monolayers", "ispublished": "pub", "full_text_status": "public", "keywords": "molecular wires; alkanethiol monolayers; biological molecules; distance dependence; free-energy; rhodobacter-sphaeroides; charge-transport; reaction centers; pathway analysis; transfer rates", "note": "Copyright \u00a9 2001 American Chemical Society.\n\nPublished In Issue: May 30, 2001. Received November 22, 2000.\n\nThis work was supported by the ONR, DARPA, and the NSF (ECS-9729405). R.E.H. and M.L.C. thank the National Institutes of Health for postdoctoral fellowships and R.H. thanks the Deutsche Forschungsgemeinschaft and the BASF-fellowship program for financial support.\n\nSupporting Information Available\nExperimental details of control experiments, plots of current\u2212voltage data, and a detailed discussion of the statistical analysis of the data (PDF). This material is available free of charge via the Internet at http://pubs.acs.org.\n\nThe affiliation listed for Dr. Andreas Terfort should have been the following:\u2009 Institute for Inorganic and Applied Chemistry, University of Hamburg, 20146, Hamburg, Germany. The compounds supplied by Dr. Terfort and used in this paper were synthesized at Hamburg. 06/21/2002\n\nSupplemental Material - ja004055c_s.pdf
", "abstract": "This paper describes an experimentally simple system for measuring rates of electron transport across organic thin films having a range of molecular structures. The system uses a metal\u2212insulator\u2212metal junction based on self-assembled monolayers (SAMs); it is particularly easy to assemble. The junction consists of a SAM supported on a silver film (Ag-SAM(1)) in contact with a second SAM supported on the surface of a drop of mercury (Hg-SAM(2))that is, a Ag-SAM(1)SAM(2)-Hg junction. SAM(1) and SAM(2) can be derived from the same or different thiols. The current that flowed across junctions with SAMs of aliphatic thiols or aromatic thiols on Ag and a SAM of hexadecane thiol on Hg depended both on the molecular structure and on the thickness of the SAM on Ag:\u2009 the current density at a bias of 0.5 V ranged from 2 \u00d7 10^-10 A/cm^2 for HS(CH_2)_15CH_3 on Ag to 1 \u00d7 10^-6 A/cm^2 for HS(CH_2)_7CH_3 on Ag, and from 3 \u00d7 10^-6 A/cm^2 for HS(Ph)_3H (Ph = 1,4-C_6H4_) on Ag to 7 \u00d7 10^-4 A/cm^2 for HSPhH on Ag. The current density increased roughly linearly with the area of contact between SAM(1) and SAM(2), and it was not different between Ag films that were 100 or 200 nm thick. The current\u2212voltage curves were symmetrical around V = 0. The current density decreased with increasing distance between the electrodes according to the relation I = I0e-\u03b2dAg,Hg, where dAg,Hg is the distance between the electrodes, and \u03b2 is the structure-dependent attenuation factor for the molecules making up SAM(1). At an applied potential of 0.5 V, \u03b2 was 0.87 \u00b1 0.1 \u00c5-1 for alkanethiols, 0.61 \u00b1 0.1 \u00c5-1 for oligophenylene thiols, and 0.67 \u00b1 0.1 \u00c5-1 for benzylic derivatives of oligophenylene thiols. The values of \u03b2 did not depend significantly on applied potential over the range of 0.1 to 1 V. These junctions provide a test bed with which to screen the intrinsic electrical properties of SAMs made up of molecules with different structures; information obtained using these junctions will be useful in correlating molecular structure and rates of electron transport.", "date": "2001-05-30", "date_type": "published", "publication": "Journal of the American Chemical Society", "volume": "123", "number": "21", "publisher": "American Chemical Society", "pagerange": "5075-5085", "id_number": "CaltechAUTHORS:20130821-160718693", "issn": "0002-7863", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20130821-160718693", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Office of Naval Research (ONR)" }, { "agency": "Defense Advanced Research Projects Agency (DARPA)" }, { "agency": "NSF", "grant_number": "ECS-9729405" }, { "agency": "NIH" }, { "agency": "Deutsche Forschungsgemeinschaft (DFG)" }, { "agency": "BASF" } ] }, "doi": "10.1021/ja004055c", "primary_object": { "basename": "ja004055c_s.pdf", "url": "https://authors.library.caltech.edu/records/wwktg-f5w34/files/ja004055c_s.pdf" }, "resource_type": "article", "pub_year": "2001", "author_list": "Holmlin, R. Erik; Haag, Rainer; et el." }, { "id": "https://authors.library.caltech.edu/records/vkf5k-mvj68", "eprint_id": 40811, "eprint_status": "archive", "datestamp": "2023-08-21 21:47:18", "lastmod": "2023-10-24 22:01:09", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Kenis-P-J-A", "name": { "family": "Kenis", "given": "Paul J. A." } }, { "id": "Ismagilov-R-F", "name": { "family": "Ismagilov", "given": "Rustem F." }, "orcid": "0000-0002-3680-4399" }, { "id": "Takayama-Shuichi", "name": { "family": "Takayama", "given": "Shuichi" } }, { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" }, { "id": "Li-Shulong", "name": { "family": "Li", "given": "Shulong" } }, { "id": "White-H-S", "name": { "family": "White", "given": "Henry S." } } ] }, "title": "Fabrication inside microchannels using fluid flow", "ispublished": "pub", "full_text_status": "restricted", "keywords": "capillary-electrophoresis; fractionation; networks; fiber; cells", "note": "Copyright \u00a9 2000 American Chemical Society. \n\nPublished In Issue: December 19, 2000. Received April 18, 2000. \n\nThe work at Harvard was supported financially by DARPA through NSF Grant ECS-97294505, and MRSEC-shared facilities supported by the NSF under Grant NSF DMR-9809363 were used. Work at the University of Utah was supported by the Office of Naval Research. P.J.A.K. acknowledges the Netherlands Organization for Scientific Research (NWO) for a postdoctoral fellowship. S.T. thanks the Leukemia and Lymphoma Society for a postdoctoral fellowship.", "abstract": "This Account summarizes techniques for carrying out microfabrication of structures with dimensions down to 10 mum in microchannels that are 0.02-2 mm wide. These methods are largely based on the exploitation of laminar flow at low Reynolds number (Re) to control the spatial delivery of reagents. These methods are illustrated by fabrication of fibers, microelectrode arrays, arrays of crystals, and patterns of proteins and cells.", "date": "2000-12-19", "date_type": "published", "publication": "Accounts of Chemical Research", "volume": "33", "number": "12", "publisher": "American Chemical Society", "pagerange": "841-847", "id_number": "CaltechAUTHORS:20130821-160721858", "issn": "0001-4842", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20130821-160721858", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "DARPA" }, { "agency": "NSF", "grant_number": "ECS-97294505" }, { "agency": "NSF", "grant_number": "DMR-9809363" }, { "agency": "Office of Naval Research" }, { "agency": "Netherlands Organization for Scientific Research (NWO)" }, { "agency": "Leukemia and Lymphoma Society" } ] }, "doi": "10.1021/ar000062u", "resource_type": "article", "pub_year": "2000", "author_list": "Kenis, Paul J. A.; Ismagilov, Rustem F.; et el." }, { "id": "https://authors.library.caltech.edu/records/w6fvd-m9p56", "eprint_id": 40876, "eprint_status": "archive", "datestamp": "2023-08-21 21:05:10", "lastmod": "2023-10-23 15:49:40", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Stroock-A-D", "name": { "family": "Stroock", "given": "Abraham D." } }, { "id": "Weck-M", "name": { "family": "Weck", "given": "Marcus" } }, { "id": "Chiu-Daniel-T", "name": { "family": "Chiu", "given": "Daniel T." } }, { "id": "Huck-W-T-S", "name": { "family": "Huck", "given": "Wilhelm T. S." } }, { "id": "Kenis-P-J-A", "name": { "family": "Kenis", "given": "Paul J. A." } }, { "id": "Ismagilov-R-F", "name": { "family": "Ismagilov", "given": "Rustem F." }, "orcid": "0000-0002-3680-4399" }, { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" } ] }, "title": "Patterning electro-osmotic flow with patterned surface charge", "ispublished": "pub", "full_text_status": "public", "keywords": "elctroosmosis; particles", "note": "\u00a9 2000 The American Physical Society. \n\nReceived 2 November 1999; published in the issue dated 10 April 2000. \n\nWe are grateful to Professor A. Ajdari (Ecole Sup\u00e9rieure\nde Physique et Chimie Industrielles de Paris) and Professor H. Stone (DEAS, Harvard University) for helpful\ndiscussions. This work was supported by DARPA: NSF\nECS-9729405, NIH: GM51559, and NSF: DMR-9809363\nMRSEC. A. D. S. was supported by NIH Molecular Biophysics Training Grant No. 5T32GM08313-10. M. W. was\nsupported by the German Academic Exchange Service\n(DAAD). P. J. A. K. was supported by Netherlands Organization for Scientific Research (NWO).\n\nPublished - PhysRevLett.84.3314.pdf
Erratum - PhysRevLett.86.6050.pdf
", "abstract": "This Letter reports the measurement of electro-osmotic flows (EOF) in microchannels with surface charge patterned on the 200 mu m scale. We have investigated two classes of patterns: (1) Those in which the surface charge varies along a direction perpendicular to the electric field used to drive the EOF; this type of pattern generates multidirectional flow along the direction of the field. (2) Those in which the surface charge pattern varies parallel to the field; this pattern generates recirculating cellular flew, and thus causes motion both parallel and perpendicular to the external field. Measurements of both of these flours agree well with theory in the Limit of thin double layers and low surface potential.", "date": "2000-04-10", "date_type": "published", "publication": "Physical Review Letters", "volume": "84", "number": "15", "publisher": "American Physical Society", "pagerange": "3314-3317", "id_number": "CaltechAUTHORS:20130821-160733045", "issn": "0031-9007", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20130821-160733045", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "DARPA" }, { "agency": "NSF", "grant_number": "ECS-9729405" }, { "agency": "NIH", "grant_number": "GM51559" }, { "agency": "NSF", "grant_number": "DMR-9809363" }, { "agency": "NIH", "grant_number": "5T32GM08313-10" }, { "agency": "German Academic Exchange Service (DAAD)" }, { "agency": "Netherlands Organization for Scientific Research (NWO)" } ] }, "doi": "10.1103/PhysRevLett.84.3314", "primary_object": { "basename": "PhysRevLett.84.3314.pdf", "url": "https://authors.library.caltech.edu/records/w6fvd-m9p56/files/PhysRevLett.84.3314.pdf" }, "related_objects": [ { "basename": "PhysRevLett.86.6050.pdf", "url": "https://authors.library.caltech.edu/records/w6fvd-m9p56/files/PhysRevLett.86.6050.pdf" } ], "resource_type": "article", "pub_year": "2000", "author_list": "Stroock, Abraham D.; Weck, Marcus; et el." }, { "id": "https://authors.library.caltech.edu/records/z555n-g6v03", "eprint_id": 40788, "eprint_status": "archive", "datestamp": "2023-08-21 20:55:56", "lastmod": "2023-10-24 21:59:30", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Deng-Tao", "name": { "family": "Deng", "given": "Tao" } }, { "id": "Arias-F", "name": { "family": "Arias", "given": "Francisco" } }, { "id": "Ismagilov-R-F", "name": { "family": "Ismagilov", "given": "Rustem F." }, "orcid": "0000-0002-3680-4399" }, { "id": "Kenis-P-J-A", "name": { "family": "Kenis", "given": "Paul J. A." } }, { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" } ] }, "title": "Fabrication of metallic microstructures using exposed, developed silver halide-based photographic film", "ispublished": "pub", "full_text_status": "restricted", "keywords": "replication; complex", "note": "Copyright \u00a9 2000 American Chemical Society.\n\nPublished In Issue: February 15, 2000. Received for review September 1, 1999. Accepted December 3, 1999.\n\nThis work was supported by DARPA and the NSF (Grant ECS-9729405). P.J.A.K. acknowledges The Netherlands Organization for Scientific Research (NWO) for a postdoctoral fellowship. We thank Scott T. Brittain for helpful discussions. This work used MRSEC shared facilities supported by the NSF (Grants DMR-9400396 and DMR-9809363).", "abstract": "This paper demonstrates that the pattern of silver particles embedded in the gelatin matrix of exposed and developed silver halide-based photographic film can serve as a template in a broadly applicable method for the microfabrication of metallic microstructures. In this method, a CAD file is reproduced in the photographic film by exposure and developing. The resulting pattern of discontinuous silver grains is augmented and made electrically continuous by electroless deposition of silver, and the electrically continuous structure is then used as the cathode for electrochemical deposition of an additional layer of the same or different metal. The overall process can be completed within 2 h, starting from a CAD file, and can generate electrically continuous structures with the smallest dimension in the plane of the film of 30 \u03bcm. Structures with aspect ratio of up to 5 can also be obtained by using the metallic structures as photomasks in photolithography using SU-8 photoresist on the top of the electroplated pattern and exposed from the bottom, followed by development and electroplating through the patterned photoresist. This method of fabrication uses readily available equipment and makes it possible to develop prototypes of a wide variety of metallic structures and devices. The resulting structures either supported on the film backing or freed from it are appropriate for use as passive, structural materials such as wire frames or meshes and can also be used in microfluidic, microanalytical, and microelectromechanical systems.", "date": "2000-02-15", "date_type": "published", "publication": "Analytical Chemistry", "volume": "72", "number": "4", "publisher": "American Chemical Society", "pagerange": "645-651", "id_number": "CaltechAUTHORS:20130821-160717870", "issn": "0003-2700", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20130821-160717870", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "DARPA" }, { "agency": "NSF", "grant_number": "ECS-9729405" }, { "agency": "Netherlands Organization for Scientific Research (NWO)" }, { "agency": "NSF", "grant_number": "DMR-9400396" }, { "agency": "NSF", "grant_number": "DMR-9809363" } ] }, "doi": "10.1021/ac991010p", "resource_type": "article", "pub_year": "2000", "author_list": "Deng, Tao; Arias, Francisco; et el." }, { "id": "https://authors.library.caltech.edu/records/0c10a-0z069", "eprint_id": 40804, "eprint_status": "archive", "datestamp": "2023-08-19 05:04:44", "lastmod": "2023-10-24 22:00:37", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Ismagilov-R-F", "name": { "family": "Ismagilov", "given": "Rustem F." }, "orcid": "0000-0002-3680-4399" }, { "id": "Stroock-A-D", "name": { "family": "Stroock", "given": "Abraham D." } }, { "id": "Kenis-P-J-A", "name": { "family": "Kenis", "given": "Paul J. A." } }, { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George" }, "orcid": "0000-0001-9451-2442" }, { "id": "Stone-H-A", "name": { "family": "Stone", "given": "Howard A." } } ] }, "title": "Experimental and theoretical scaling laws for transverse diffusive broadening in two-phase laminar flows in microchannels", "ispublished": "pub", "full_text_status": "public", "keywords": "mass-transfer, two-phase flow, chemically reactive flow, laminar flow, channel flow, flow visualisation, fluorescence, optical microscopy, scaling phenomena, chemical interdiffusion, reaction-diffusion systems", "note": "\u00a9 2000 American Institute of Physics.\n\n(Received 29 October 1999; accepted 24 February 2000)\n\nThis work was supported by DARPA, NSF ECS-9729405 [for one of the authors (G.M.W.)]; by DARPA Army Research Office DAAG55-97-1-0114 [for one of the authors (H.A.S.)], and by the NSF MRSEC DMR-9809363 [for two of the authors (G.M.W. and H.A.S.)]. One of the authors (A.D.S.) was supported by NIH Molecular Biophysical Training Grant No. 5T32GM08313-10. The authors acknowledge Shuichi Takayama for helpful suggestions.\n\nPublished - ApplPhysLett_76_2376.pdf
", "abstract": "This letter quantifies both experimentally and theoretically the diffusion of low-molecular-weight species across the interface between two aqueous solutions in pressure-driven laminar flow in microchannels at high Peclet numbers. Confocal fluorescent microscopy was used to visualize a fluorescent product formed by reaction between chemical species carried separately by the two solutions. At steady state, the width of the reaction-diffusion zone at the interface adjacent to the wall of the channel and transverse to the direction of flow scales as the one-third power of both the axial distance down the channel (from the point where the two streams join) and the average velocity of the flow, instead of the more familiar one- half power scaling which was measured in the middle of the channel. A quantitative description of reaction-diffusion processes near the walls of the channel, such as described in this letter, is required for the rational use of laminar flows for performing spatially resolved surface chemistry and biology inside microchannels and for understanding three-dimensional features of mass transport in shearing flows near surfaces.", "date": "2000", "date_type": "published", "publication": "Applied Physics Letters", "volume": "76", "number": "17", "publisher": "American Institute of Physics", "pagerange": "2376-2378", "id_number": "CaltechAUTHORS:20130821-160720579", "issn": "0003-6951", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20130821-160720579", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "DARPA" }, { "agency": "NSF", "grant_number": "ECS-9729405" }, { "agency": "Army Research Office", "grant_number": "DAAG55-97-1-0114" }, { "agency": "NSF", "grant_number": "DMR-9809363" }, { "agency": "NIH", "grant_number": "5T32GM08313-10" } ] }, "doi": "10.1063/1.126351", "primary_object": { "basename": "ApplPhysLett_76_2376.pdf", "url": "https://authors.library.caltech.edu/records/0c10a-0z069/files/ApplPhysLett_76_2376.pdf" }, "resource_type": "article", "pub_year": "2000", "author_list": "Ismagilov, Rustem F.; Stroock, Abraham D.; et el." }, { "id": "https://authors.library.caltech.edu/records/xg3ce-ad362", "eprint_id": 40812, "eprint_status": "archive", "datestamp": "2023-08-22 13:53:05", "lastmod": "2023-10-24 22:01:11", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Kenis-P-J-A", "name": { "family": "Kenis", "given": "Paul J. A." } }, { "id": "Ismagilov-R-F", "name": { "family": "Ismagilov", "given": "Rustem F." }, "orcid": "0000-0002-3680-4399" }, { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" } ] }, "title": "Microfabrication inside capillaries using multiphase laminar flow patterning", "ispublished": "pub", "full_text_status": "public", "keywords": "calcium-phosphate; microemulsions", "note": "\u00a9 1999 American Association for the Advancement of Science.\n\nReceived for publication 9 February 1999. Accepted for publication 15 April 1999. \n\nThis work was financially supported by the Defense Advanced Research Projects Agency and NSF grant ECS-9729405. Materials Research Science and Engineering Center\u2013shared facilities supported by the NSF under grant DMR-9400396 were used. P.J.A.K. acknowledges the Netherlands Organization for Scientific Research (NWO) for a postdoctoral fellowship. We acknowledge W. Huck and Y. Lu for their help with the atomic force microscopy and scanning electron microscopy experiments.\n\nPublished - Science-1999-Kenis-83-5.pdf
", "abstract": "The reaction of species in solutions flowing laminarly (without turbulent mixing) inside capillaries was used as the basis for a broadly applicable method of microfabrication. In this method, patterning occurs as a result of transport of reactive species to interfaces within the capillary by laminar flow. A wide range of chemistries can be used to generate structures with feature sizes of less than 5 micrometers and with spatial localization to within 5 micrometers. The method is applicable to the patterning of metals, organic polymers, inorganic crystals, and ceramics on the inner walls of preformed capillaries, using both additive and subtractive processes.", "date": "1999-07-02", "date_type": "published", "publication": "Science", "volume": "285", "number": "5424", "publisher": "American Association for the Advancement of Science", "pagerange": "83-85", "id_number": "CaltechAUTHORS:20130821-160722004", "issn": "0036-8075", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20130821-160722004", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Defense Advanced Research Projects Agency (DARPA)" }, { "agency": "NSF", "grant_number": "ECS-9729405" }, { "agency": "NSF", "grant_number": "DMR-9400396" }, { "agency": "Netherlands Organization for Scientific Research (NWO)" } ] }, "doi": "10.1126/science.285.5424.83", "primary_object": { "basename": "Science-1999-Kenis-83-5.pdf", "url": "https://authors.library.caltech.edu/records/xg3ce-ad362/files/Science-1999-Kenis-83-5.pdf" }, "resource_type": "article", "pub_year": "1999", "author_list": "Kenis, Paul J. A.; Ismagilov, Rustem F.; et el." }, { "id": "https://authors.library.caltech.edu/records/5bzbc-s3b95", "eprint_id": 40879, "eprint_status": "archive", "datestamp": "2023-08-22 13:46:54", "lastmod": "2023-10-24 22:32:31", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Takayama-Shuichi", "name": { "family": "Takayama", "given": "Shuichi" } }, { "id": "McDonald-J-Cooper", "name": { "family": "McDonald", "given": "J. Cooper" } }, { "id": "Ostuni-E", "name": { "family": "Ostuni", "given": "Emanuele" } }, { "id": "Liang-Michael-N", "name": { "family": "Liang", "given": "Michael N." } }, { "id": "Kenis-P-J-A", "name": { "family": "Kenis", "given": "Paul J. A." } }, { "id": "Ismagilov-R-F", "name": { "family": "Ismagilov", "given": "Rustem F." }, "orcid": "0000-0002-3680-4399" }, { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" } ] }, "title": "Patterning cells and their environments using multiple laminar fluid flows in capillary networks", "ispublished": "pub", "full_text_status": "public", "keywords": "fibronectin; proteins; surfaces; growth; matrix; shape", "note": "\u00a9 1999, The National Academy of Sciences. \n\nAccepted March 17, 1999. \n\nSupported by the Defense Advanced Research Planning Agency (DARPA)/Space and Naval Warfare Systems Command, DARPA/Office of Naval Research, the National Science Foundation (NSF ECS-9729405), and the National Institutes of Health (NIH GM30367). We thank Prof. D. E. Ingber (Harvard Medical School) for use of his facilities and Dr. S. Warren (Massachusetts General Hospital) for the gift of E. coli (RB 128). S. T. is a Leukemia Society of America Fellow and thanks the society for a postdoctoral fellowship. J. C. M. thanks the National Science Foundation for a predoctoral fellowship. P. J. A. K. thanks the Netherlands Organization for Scientific Research (NWO) for a postdoctoral fellowship.\n\nPublished - PNAS-1999-Takayama-5545-8.pdf
Accepted Version - pq005545.pdf
", "abstract": "This paper describes the use of laminar flow of liquids in capillary systems to pattern the cell culture substrate, to perform patterned cell deposition, and to pattern the cell culture media. We demonstrate the patterning of the cell culture substrate with different proteins, the patterning of different types of cells adjacent to each other, the patterned delivery of chemicals to adhered cells, and performing enzymatic reactions over select cells or over a portion of a cell. This method offers a way to simultaneously control the characteristics of the surface to which cells are attached, the type of cells that are in their vicinity, and the kind of media that cells or part of a cell are exposed to. The method is experimentally simple, highly adaptable, and requires no special equipment except for an elastomeric relief that can be readily prepared by rapid prototyping.", "date": "1999-05-11", "date_type": "published", "publication": "Proceedings of the National Academy of Sciences of the United States of America", "volume": "96", "number": "10", "publisher": "National Academy of Sciences", "pagerange": "5545-5548", "id_number": "CaltechAUTHORS:20130821-160733567", "issn": "0027-8424", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20130821-160733567", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Defense Advanced Research Planning Agency (DARPA)" }, { "agency": "Office of Naval Research (ONR)" }, { "agency": "NSF", "grant_number": "ECS-9729405" }, { "agency": "NIH", "grant_number": "GM30367" }, { "agency": "Leukemia Society of America" }, { "agency": "Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)" } ] }, "doi": "10.1073/pnas.96.10.5545", "pmcid": "PMC21896", "primary_object": { "basename": "PNAS-1999-Takayama-5545-8.pdf", "url": "https://authors.library.caltech.edu/records/5bzbc-s3b95/files/PNAS-1999-Takayama-5545-8.pdf" }, "related_objects": [ { "basename": "pq005545.pdf", "url": "https://authors.library.caltech.edu/records/5bzbc-s3b95/files/pq005545.pdf" } ], "resource_type": "article", "pub_year": "1999", "author_list": "Takayama, Shuichi; McDonald, J. Cooper; et el." }, { "id": "https://authors.library.caltech.edu/records/ekp2c-92x14", "eprint_id": 40889, "eprint_status": "archive", "datestamp": "2023-08-22 13:42:42", "lastmod": "2023-10-24 22:33:23", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" }, { "id": "Ismagilov-R-F", "name": { "family": "Ismagilov", "given": "Rustem F." }, "orcid": "0000-0002-3680-4399" } ] }, "title": "Complexity in chemistry", "ispublished": "pub", "full_text_status": "public", "keywords": "oscillatory kinetics; molecules; dynamics; shape", "note": "\u00a9 1999 American Association for the Advancement of Science. \n\nThis work was supported by the Defense Advanced Research Projects Agency and by NIH grant GM30367. We acknowledge F. Frankel for providing Fig. 2.\n\nPublished - Complexity.pdf
", "abstract": "\"Complexity\" is a subject that is beginning to be important in chemistry. Historically, chemistry has emphasized the approximation of complex nonlinear processes by simpler Linear ones. Complexity is becoming a profitable approach to a wide range of problems, especially the understanding of Life.", "date": "1999-04-02", "date_type": "published", "publication": "Science", "volume": "284", "number": "5411", "publisher": "American Association for the Advancement of Science", "pagerange": "89-92", "id_number": "CaltechAUTHORS:20130821-160735218", "issn": "0036-8075", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20130821-160735218", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Defense Advanced Research Projects Agency (DARPA)" }, { "agency": "NIH", "grant_number": "GM30367" } ] }, "doi": "10.1126/science.284.5411.89", "primary_object": { "basename": "Complexity.pdf", "url": "https://authors.library.caltech.edu/records/ekp2c-92x14/files/Complexity.pdf" }, "resource_type": "article", "pub_year": "1999", "author_list": "Whitesides, George M. and Ismagilov, Rustem F." }, { "id": "https://authors.library.caltech.edu/records/mxp4g-pgt35", "eprint_id": 61166, "eprint_status": "archive", "datestamp": "2023-08-19 05:10:39", "lastmod": "2023-10-24 23:45:18", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" }, { "id": "Roberts-J-D", "name": { "family": "Roberts", "given": "John D." } } ] }, "title": "Nuclear Magnetic Resonance Spectroscopy. The Configurational Stability of Primary Grignard Reagents. Structure and Medium Effects", "ispublished": "pub", "full_text_status": "restricted", "note": "\u00a9 1965 American Chemical Society. \n\nReceived January 9, 1965. \n\nSupported in part by the Office of Naval Research and the National Science Foundation.", "abstract": "Qualitative and semiquantitative examination of the temperature dependence of the RCH_2-Mg proton n.m.r. spectra of several Grignard reagents indicates that the rate of inversion at this center is relatively insensitive to the structure of the group R. Secondary Grignard reagents invert much more slowly, if at all. The dependence of the inversion rate of the primary organometallic compounds on solvent character and on added salts suggests that inversion proceeds by means of a mechanism having kinetic order greater than one.", "date": "1965-11-01", "date_type": "published", "publication": "Journal of the American Chemical Society", "volume": "87", "number": "21", "publisher": "American Chemical Society", "pagerange": "4878-4888", "id_number": "CaltechAUTHORS:20151015-104928972", "issn": "0002-7863", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20151015-104928972", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Office of Naval Research (ONR)" }, { "agency": "NSF" } ] }, "other_numbering_system": { "items": [ { "id": "3172", "name": "Caltech Gates and Crellin Laboratories of Chemistry" } ] }, "doi": "10.1021/ja00949a035", "resource_type": "article", "pub_year": "1965", "author_list": "Whitesides, George M. and Roberts, John D." }, { "id": "https://authors.library.caltech.edu/records/tf71n-hwq65", "eprint_id": 61158, "eprint_status": "archive", "datestamp": "2023-08-19 05:03:46", "lastmod": "2023-10-24 23:44:56", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" }, { "id": "Witanowski-M", "name": { "family": "Witanowski", "given": "Michal" } }, { "id": "Roberts-J-D", "name": { "family": "Roberts", "given": "John D." } } ] }, "title": "Magnetic Resonance Spectroscopy. The Configurational Stability of Primary Grignard Reagents. 3,3-Dimethylbutylmagnesium Chloride", "ispublished": "pub", "full_text_status": "restricted", "note": "\u00a9 1965 American Chemical Society. \n\nReceived January 9, 1965. \n\nSupported in part by the Office of Naval Research and the National Science Foundation. Presented at the 10th Reaction Mechanisms Conference, Corvallis, Ore., June 24, 1964.", "abstract": "Detailed examination of the temperature dependence of the n.m.r. spectra of 3,3-dimethylbutylmagnesium chloride and bis(3,3-dimethylbutyl)magnesium indicates that inversion of configuration at the -CH_2Mg center occurs rapidly in ether solution at room temperature.", "date": "1965-07-01", "date_type": "published", "publication": "Journal of the American Chemical Society", "volume": "87", "number": "13", "publisher": "American Chemical Society", "pagerange": "2854-2862", "id_number": "CaltechAUTHORS:20151015-104907132", "issn": "0002-7863", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20151015-104907132", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Office of Naval Research (ONR)" }, { "agency": "NSF" } ] }, "other_numbering_system": { "items": [ { "id": "3186", "name": "Caltech Gates and Crellin Laboratories of Chemistry" } ] }, "doi": "10.1021/ja01091a014", "resource_type": "article", "pub_year": "1965", "author_list": "Whitesides, George M.; Witanowski, Michal; et el." }, { "id": "https://authors.library.caltech.edu/records/2a4f4-hg868", "eprint_id": 61174, "eprint_status": "archive", "datestamp": "2023-08-19 05:03:55", "lastmod": "2023-10-24 23:45:42", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Gwynn-D-E", "name": { "family": "Gwynn", "given": "Donald E." } }, { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" }, { "id": "Roberts-J-D", "name": { "family": "Roberts", "given": "John D." } } ] }, "title": "Nuclear Magnetic Resonance Spectroscopy. Temperature Dependence of the Spectrum of Fluorocyclooctatetraene", "ispublished": "pub", "full_text_status": "restricted", "note": "\u00a9 1965 American Chemical Society. \n\nReceived March 5, 1965. \n\nSupported in part by the Office of Naval Research.", "abstract": "The fluorine n.m.r. spectrum of fluorocyclootatetraene has been shown to be temperature dependent between 30 and 65\u00ba. This is attributed to changes in the rate of an inversion-bond-shift process which is slow on the n.m.r. time scale at low temperatures. The free energy of activation for inversion is approximately 12 kcal/mole at -33\u00ba.", "date": "1965-07-01", "date_type": "published", "publication": "Journal of the American Chemical Society", "volume": "87", "number": "13", "publisher": "American Chemical Society", "pagerange": "2862-2864", "id_number": "CaltechAUTHORS:20151015-104930928", "issn": "0002-7863", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20151015-104930928", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Office of Naval Research (ONR)" } ] }, "other_numbering_system": { "items": [ { "id": "3184", "name": "Caltech Gates and Crellin Laboratories of Chemistry" } ] }, "doi": "10.1021/ja01091a015", "resource_type": "article", "pub_year": "1965", "author_list": "Gwynn, Donald E.; Whitesides, George M.; et el." }, { "id": "https://authors.library.caltech.edu/records/brveb-yny62", "eprint_id": 61198, "eprint_status": "archive", "datestamp": "2023-08-19 04:58:41", "lastmod": "2023-10-24 23:51:27", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" }, { "id": "Grocki-J-J", "name": { "family": "Grocki", "given": "John J." } }, { "id": "Holtz-D", "name": { "family": "Holtz", "given": "David" } }, { "id": "Steinberg-H", "name": { "family": "Steinberg", "given": "Herbert" } }, { "id": "Roberts-J-D", "name": { "family": "Roberts", "given": "John D." } } ] }, "title": "Nuclear Magnetic Resonance Spectroscopy. The Effect of Solvent on Magnetic Nonequivalence Arising from Molecular Asymmetry", "ispublished": "pub", "full_text_status": "restricted", "note": "\u00a9 1965 American Chemical Society. \n\nReceived September 18, 1964. \n\nSupported in part by the Office of Naval Research and the undergraduate research participation program of the National Science Foundation; N.A.T.O. Fellow, 1963.", "abstract": "The chemical shift between the geminal methylene protons of 1-phenylethyl benzyl ether has been measured in a variety of solvents. An approximate correlation observed between solvent dielectric constant and the degree of the magnetic nonequivalence of the methylene protons, V_A - V_B, is discussed in light of similar results for structurally related compounds. It is suggested that the variation in V_A - V_B with solvent may reflect changes in the conformation of the benzylic phenyl ring with respect to the methylene group.", "date": "1965-03-01", "date_type": "published", "publication": "Journal of the American Chemical Society", "volume": "87", "number": "5", "publisher": "American Chemical Society", "pagerange": "1058-1064", "id_number": "CaltechAUTHORS:20151016-101609996", "issn": "0002-7863", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20151016-101609996", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Office of Naval Research (ONR)" }, { "agency": "NSF Undergraduate Research Program" }, { "agency": "NATO fellowship" } ] }, "other_numbering_system": { "items": [ { "id": "3157", "name": "Caltech Gates and Crellin Laboratories of Chemistry" } ] }, "doi": "10.1021/ja01083a022", "resource_type": "article", "pub_year": "1965", "author_list": "Whitesides, George M.; Grocki, John J.; et el." }, { "id": "https://authors.library.caltech.edu/records/4df13-9n941", "eprint_id": 61202, "eprint_status": "archive", "datestamp": "2023-08-19 04:46:24", "lastmod": "2023-10-25 14:35:03", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" }, { "id": "Holtz-D", "name": { "family": "Holtz", "given": "David" } }, { "id": "Roberts-J-D", "name": { "family": "Roberts", "given": "John D." } } ] }, "title": "Nuclear Magnetic Resonance Spectroscopy. The Effect of Structure on Magnetic Nonequivalence Due to Molecular Asymmetry", "ispublished": "pub", "full_text_status": "restricted", "note": "\u00a9 1964 American Chemical Society. \n\nReceived February 20, 1964. \n\nSupported in part by the Office of Naval Research and the Undergraduate Research Participation Program of the National Science Foundation.", "abstract": "The difference in chemical shift between the methylene protons of a number of compounds related structurally to 1-phenylethyl benzyl ether has been measured. Correlations between structural features of these compounds and the magnitude of the magnetic nonequivalence induced by the center of molecular asymmetry provide a basis for qualitative identification of the most important factors contributing to the chemical-shift difference. Although it is clear that no single factor Completely determines the magnitude of the methylene proton nonequivalence in these ethers, it is suggested that the proximity of the asymmetric center to the benzyl group results in a preferred conformation of the phenyl ring with respect to the methylene protons, and that the principal contribution to the nonequivalence originates in the magnetic anisotropy of the phenyl group.", "date": "1964-07-01", "date_type": "published", "publication": "Journal of the American Chemical Society", "volume": "86", "number": "13", "publisher": "American Chemical Society", "pagerange": "2628-2634", "id_number": "CaltechAUTHORS:20151016-112436493", "issn": "0002-7863", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20151016-112436493", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Office of Naval Research (ONR)" }, { "agency": "NSF Undergraduate Research Program" } ] }, "other_numbering_system": { "items": [ { "id": "3072", "name": "Caltech Gates and Crellin Laboratories of Chemistry" } ] }, "doi": "10.1021/ja01067a022", "resource_type": "article", "pub_year": "1964", "author_list": "Whitesides, George M.; Holtz, David; et el." }, { "id": "https://authors.library.caltech.edu/records/0204d-m1j50", "eprint_id": 61219, "eprint_status": "archive", "datestamp": "2023-08-19 04:44:49", "lastmod": "2023-10-25 14:38:17", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" }, { "id": "Roberts-J-D", "name": { "family": "Roberts", "given": "John D." } } ] }, "title": "Long-Range Proton Spin\u2014Spin Coupling in Dimethyl Sulfone", "ispublished": "pub", "full_text_status": "restricted", "note": "\u00a9 1964 American Chemical Society. \n\nReceived November 26, 1963. \n\nSupported in part by the Office of Naval Research and National Science Foundation. Contribution No. 3040.", "abstract": "A wide variety of chemical and spectral data suggest that a sulforic group is capable of interaction with an adjacent unsaturated center ; however, it seems possible that the mode of this interaction may be significantly different from that of conjugation between first-row elements. Moffit's molecular orbital treatment of sulfone groups indicates that two distinct types of conjugation are possible: \"direct\" conjugation utilizing the filled sulfur-oxygen molecular orbitals for overlap with an adjacent center, and \"charge-transfer\" conjugation, involving donation of electrons from the adjacent center into utifilled sulfone molecular orbitals having predominantly d-orbital character. It is difficult to distinguish experimentally between these alternatives, but analysis of the e.p.r. spectrum of thioxanthone S,S-dioxide mononegative ion led Vincow to conclude that a charge-transfer mechanism was responsible for the observed conjugation through the sulfone group.", "date": "1964-06", "date_type": "published", "publication": "Journal of Physical Chemistry", "volume": "68", "number": "6", "publisher": "American Chemical Society", "pagerange": "1583-1584", "id_number": "CaltechAUTHORS:20151016-143423827", "issn": "0022-3654", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20151016-143423827", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Office of Naval Research (ONR)" }, { "agency": "NSF" } ] }, "other_numbering_system": { "items": [ { "id": "3040", "name": "Caltech Gates and Crellin Laboratories of Chemistry" } ] }, "doi": "10.1021/j100788a512", "resource_type": "article", "pub_year": "1964", "author_list": "Whitesides, George M. and Roberts, John D." }, { "id": "https://authors.library.caltech.edu/records/tx7kv-69g75", "eprint_id": 61206, "eprint_status": "archive", "datestamp": "2023-08-19 04:28:06", "lastmod": "2023-10-25 14:35:17", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" }, { "id": "Beauchamp-J-L", "name": { "family": "Beauchamp", "given": "Jesse L." }, "orcid": "0000-0001-8839-4822" }, { "id": "Roberts-J-D", "name": { "family": "Roberts", "given": "John D." } } ] }, "title": "Relative Signs of the ^(31)P-^1H and ^(31)P-C-^1H Nuclear Magnetic Resonance Coupling Constants", "ispublished": "pub", "full_text_status": "restricted", "note": "\u00a9 1963 American Chemical Society. \n\nReceived July 1, 1963. \n\n\nSupported in part by the Office of Naval Research and the National Science Foundation.", "abstract": "The possibility that terms other than Fermi contact interaction make significant contributions to nuclear spin-spin coupling with heavy nuclei has stimulated considerable interest in the n.m.r. spectra of compounds containing heteroatoms. In particular, relative signs and magnitudes of J_(XCH) and J_(XCCH) have be en reported for ethyl derivatives of several heavy isotopes of spin 1/2. In order to understand better the factors responsible for spin coupling with a representative heavy nucleus, we have analyzed the spectra of (CH_3)_3P, (CH_3)_2PH, and (CH_3)PH_2 and have obtained relative signs and magnitudes of J_(PH) and J_(PCH).", "date": "1963-09-01", "date_type": "published", "publication": "Journal of the American Chemical Society", "volume": "85", "number": "17", "publisher": "American Chemical Society", "pagerange": "2665-2666", "id_number": "CaltechAUTHORS:20151016-112437738", "issn": "0002-7863", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20151016-112437738", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Office of Naval Research (ONR)" }, { "agency": "NSF" } ] }, "other_numbering_system": { "items": [ { "id": "2967", "name": "Caltech Gates and Crellin Laboratories of Chemistry" } ] }, "doi": "10.1021/ja00900a032", "resource_type": "article", "pub_year": "1963", "author_list": "Whitesides, George M.; Beauchamp, Jesse L.; et el." }, { "id": "https://authors.library.caltech.edu/records/hws7d-cpc50", "eprint_id": 61207, "eprint_status": "archive", "datestamp": "2023-08-19 04:24:57", "lastmod": "2023-10-25 14:35:19", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" }, { "id": "Kaplan-F", "name": { "family": "Kaplan", "given": "Fred" }, "orcid": "0000-0002-9565-0211" }, { "id": "Roberts-J-D", "name": { "family": "Roberts", "given": "John D." } } ] }, "title": "The Configurational Stability of Primary Grignard Reagents", "ispublished": "pub", "full_text_status": "restricted", "note": "\u00a9 1963 American Chemical Society. \n\nReceived May 28, 1963. \n\nSupported in part by the Office of Naval Research and The National Science Foundation.", "abstract": "The n.m.r. spectrum of the methylene hydrogens of 3,3-dimethylbutylmagnesium chloride in diethyl ether that the trans and gauche coupling constants, J_t and J_g, have the same respective values for each conformation (I-III), the separation of the outer lines for I should be ( J_t + J_g), while the corresponding separation for a rapidly interconverting mixture of II and III would be 1/2(J_t + 3J_g). Therefore, if the averaging of coupling constants observed in the high-temperature spectra is a consequence of changes in conformational populations, the separation of the outer lines would be expected to change appreciably with temperature.", "date": "1963-07-01", "date_type": "published", "publication": "Journal of the American Chemical Society", "volume": "85", "number": "14", "publisher": "American Chemical Society", "pagerange": "2167-2168", "id_number": "CaltechAUTHORS:20151016-112438109", "issn": "0002-7863", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20151016-112438109", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Office of Naval Research (ONR)" }, { "agency": "NSF" } ] }, "other_numbering_system": { "items": [ { "id": "2972", "name": "Caltech Gates and Crellin Laboratories of Chemistry" } ] }, "doi": "10.1021/ja00897a030", "resource_type": "article", "pub_year": "1963", "author_list": "Whitesides, George M.; Kaplan, Fred; et el." }, { "id": "https://authors.library.caltech.edu/records/r2pgn-jv915", "eprint_id": 6170, "eprint_status": "archive", "datestamp": "2023-08-21 23:07:34", "lastmod": "2023-10-16 20:10:26", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" }, { "id": "Kaplan-F", "name": { "family": "Kaplan", "given": "Fred" }, "orcid": "0000-0002-9565-0211" }, { "id": "Nagarajan-K", "name": { "family": "Nagarajan", "given": "K." } }, { "id": "Roberts-J-D", "name": { "family": "Roberts", "given": "John D." } } ] }, "title": "Nuclear Magnetic Resonance Spectroscopy: Abnormal Splitting of Ethyl Groups Due to Molecular Asymmetry, III", "ispublished": "pub", "full_text_status": "public", "note": "Copyright \u00a9 2005 by the National Academy of Sciences \n\nCommunicated May 11, 1962 \n\nSupported in part by the Office of Naval Research and the National Science Foundation. \n\nGates and Crellin Laboratories of Chemistry Contribution No. 2842.", "abstract": "The protons of a methylene group removed by one or more bonds from a center of molecular asymmetry may be magnetically nonequivalent and display AB-type nuclear magnetic resonance (n.m.r.) spectra [1-4]. It has been suggested that the chemical shift between the two methylene protons arises from unequal populations of the possible rotational conformations. However, even assuming equal populations and rapid interconversion of the three conformers I, II, and III, Ha and Hb are always distinct and identifiable, since no two conformers are identical except for interchange of Ha and Hb [5,6]. This \"intrinsic asymmetry\" of the methylene group might also be the cause of the observed magnetic nonequivalence of the methylene protons.", "date": "1962-07-01", "date_type": "published", "publication": "Proceedings of the National Academy of Sciences of the United States of America", "volume": "48", "number": "7", "publisher": "National Academy of Sciences", "pagerange": "1112-1114", "id_number": "CaltechAUTHORS:WHIpnas62", "issn": "0027-8424", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:WHIpnas62", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "primary_object": { "basename": "WHIpnas62.pdf", "url": "https://authors.library.caltech.edu/records/r2pgn-jv915/files/WHIpnas62.pdf" }, "resource_type": "article", "pub_year": "1962", "author_list": "Whitesides, George M.; Kaplan, Fred; et el." }, { "id": "https://authors.library.caltech.edu/records/q1832-5mm10", "eprint_id": 61236, "eprint_status": "archive", "datestamp": "2023-08-19 04:05:32", "lastmod": "2023-10-25 14:38:45", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" }, { "id": "Nordlander-J-E", "name": { "family": "Nordlander", "given": "J. Eric." } }, { "id": "Roberts-J-D", "name": { "family": "Roberts", "given": "John D." } } ] }, "title": "Nuclear Magnetic Resonance Spectroscopy. \u03b3,\u03b3-Dimethylallylmagnesium Bromide", "ispublished": "pub", "full_text_status": "restricted", "note": "\u00a9 1962 American Chemical Society. \n\nReceived March 7, 1962. \n\nSupported in part by the Office of Naval Research.", "abstract": "The nuclear magnetic resonance (n.m.r.) spectrum of allylmagnesium bromide is characterized by a simplicity inconsistent with any single classical structure; notably, the \u03b1 and \u03b3 protons occupy magnetically equivalent positions.", "date": "1962-05", "date_type": "published", "publication": "Journal of the American Chemical Society", "volume": "84", "number": "10", "publisher": "American Chemical Society", "pagerange": "2010-2011", "id_number": "CaltechAUTHORS:20151016-153850136", "issn": "0002-7863", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20151016-153850136", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Office of Naval Research (ONR)" } ] }, "other_numbering_system": { "items": [ { "id": "2822", "name": "Caltech Gates and Crellin Laboratories of Chemistry" } ] }, "doi": "10.1021/ja00869a052", "resource_type": "article", "pub_year": "1962", "author_list": "Whitesides, George M.; Nordlander, J. Eric.; et el." }, { "id": "https://authors.library.caltech.edu/records/qxev5-keb92", "eprint_id": 42948, "eprint_status": "archive", "datestamp": "2023-08-19 03:57:58", "lastmod": "2023-10-25 23:09:56", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Whitesides-G-M", "name": { "family": "Whitesides", "given": "George M." }, "orcid": "0000-0001-9451-2442" }, { "id": "Nordlander-J-E", "name": { "family": "Nordlander", "given": "J. Eric" } }, { "id": "Roberts-J-D", "name": { "family": "Roberts", "given": "John D." } } ] }, "title": "Nuclear Magnetic Resonance Spectroscopy. Structure and Dynamic Character of Allylic Grignard Reagents", "ispublished": "pub", "full_text_status": "public", "note": "\u00a9 1962 Royal Society of Chemistry.\nReceived 1st June, 1962.\nSupported in part by the Office of Naval Research.\n\nPublished - WHIdfs62.pdf
", "abstract": "Studies have been made of the nuclear magnetic resonance spectra of several allylic Grignard\nreagents. The Grignard reagent prepared from \u03b3,\u03b3-dimethylallyl bromide appears best formulated\nas an equilibrium mixture of \u03b3,\u03b3-dimethylallylmagnesium bromide and \u03b1,\u03b1-dimethylallylmagnesium\nbromide, in which the former is the major component. The rate of interconversion of the allylic\nisomers is rapid on the n.m.r. time scale at room temperature, but slow at -40\u00b0.", "date": "1962", "date_type": "published", "publication": "Discussions of the Faraday Society", "volume": "34", "publisher": "Royal Society of Chemistry", "pagerange": "185-190", "id_number": "CaltechAUTHORS:20131211-095900745", "issn": "0366-9033", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20131211-095900745", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Office of Naval Research (ONR)" } ] }, "other_numbering_system": { "items": [ { "id": "2847", "name": "Caltech Gates and Crellin Laboratories of Chemistry" } ] }, "doi": "10.1039/DF9623400185", "primary_object": { "basename": "WHIdfs62.pdf", "url": "https://authors.library.caltech.edu/records/qxev5-keb92/files/WHIdfs62.pdf" }, "resource_type": "article", "pub_year": "1962", "author_list": "Whitesides, George M.; Nordlander, J. Eric; et el." } ]