West, Anthony

Article from CaltechAUTHORS

• Gristick, Harry B. and Hartweger, Harald, el al. (2025) Design and characterization of HIV-1 vaccine candidates to elicit antibodies targeting multiple epitopes; Journal of Experimental Medicine; Vol. 222; No. 10; e20250693; 10.1084/jem.20250693
• Gieselmann, Lutz and DeLaitsch, Andrew T., el al. (2025) Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy; Nature Immunoogy; Vol. 26; 2016–2029; 10.1038/s41590-025-02286-5
• Dam, Kim-Marie A. and Gristick, Harry B., el al. (2025) Mapping essential somatic hypermutations in a CD4-binding site bNAb informs HIV-1 vaccine design; Cell Reports; Vol. 44; No. 5; 115713; PMCID PMC12117015; 10.1016/j.celrep.2025.115713
• Fan, Chengcheng and Keeffe, Jennifer R., el al. (2025) Cross-reactive sarbecovirus antibodies induced by mosaic RBD nanoparticles; Proceedings of the National Academy of Sciences; Vol. 122; No. 21; e2501637122; PMCID PMC12130868; 10.1073/pnas.2501637122
• Wang, Zijun and Barnes, Christopher O., el al. (2020) A broadly neutralizing macaque monoclonal antibody against the HIV-1 V3-Glycan patch; eLife; Vol. 9; Art. No. e61991; PMCID PMC7577740; 10.7554/eLife.61991
• Ladinsky, Mark S. and Gnanapragasam, Priyanthi N. P., el al. (2020) Electron tomography visualization of HIV-1 fusion with target cells using fusion inhibitors to trap the pre-hairpin intermediate; eLife; Vol. 9; Art. No. e58411; PMCID PMC7394545; 10.7554/eLife.58411
• Escolano, Amelia and West, Anthony P., Jr., el al. (2019) Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques; Nature; Vol. 570; No. 7762; 468-473; PMCID PMC6657810; 10.1038/s41586-019-1250-z
• Escolano, Amelia and Gristick, Harry B., el al. (2018) Sequential Immunization Strategies to Elicit HIV-1 bNAbs in Animal Models With a Polyclonal B Cell Repertoire; AIDS Research and Human Retroviruses; Vol. 34; No. S1; 331; 10.1089/aid.2018.5000.abstracts
• Gristick, Harry and van Schooten, Jelle, el al. (2018) Engineering HIV Immunogens to Elicit IOMA-like Antibodies Targeting the CD4 Binding Site; AIDS Research and Human Retroviruses; Vol. 34; No. S1; 59; 10.1089/aid.2018.5000.abstracts
• Mendoza, Pilar and West, Anthony P., Jr., el al. (2018) Combination therapy with anti-HIV-1 antibodies maintains viral suppression; Nature; Vol. 561; No. 7724; 479-484; PMCID PMC6166473; 10.1038/s41586-018-0531-2
• Caskey, Marina and West, Anthony P., Jr., el al. (2017) Antibody 10-1074 suppresses viremia in HIV-1-infected individuals; Nature Medicine; Vol. 23; No. 2; 185-191; PMCID PMC5467219; 10.1038/nm.4268
• Gristick, Harry B. and von Boehmer, Lotta, el al. (2016) Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site; Nature Structural & Molecular Biology; Vol. 23; No. 10; 906-915; PMCID PMC5127623; 10.1038/nsmb.3291
• Gristick, Harry and von Boehmer, Lotta, el al. (2016) Structure of a Natively-glycosylated HIV-1 Env Reveals a New Mode for VH1-2 Antibody Recognition of the CD4 Binding Site Relevant to Vaccine Design; AIDS Research and Human Retroviruses; Vol. 32; No. Suppl. 1; 62
• Scharf, Louise and West, Anthony P. , Jr., el al. (2016) Structural basis for germline antibody recognition of HIV-1 immunogens; eLife; Vol. 5; Art. No. e13783; PMCID PMC4811768; 10.7554/eLife.13783
• Davenport, Yunji W. and West, Anthony P., el al. (2016) Structure of an HIV-2 gp120 in complex with CD4; Journal of Virology; Vol. 90; No. 4; 2112-2118; PMCID PMC4733984; 10.1128/JVI.02678-15
• Yoon, Hyejin and Macke, Jennifer, el al. (2015) CATNAP: a tool to compile, analyze and tally neutralizing antibody panels; Nucleic Acids Research; Vol. 43; No. W1; W213-W219; PMCID PMC4489231; 10.1093/nar/gkv404
• Barbian, Hannah J. and Galimidi, Rachel P., el al. (2015) Neutralization Properties of Simian Immunodeficiency Viruses Infecting Chimpanzees and Gorillas; mBio; Vol. 6; No. 2; Art. No. e00296; PMCID PMC4453581; 10.1128/mBio.00296-15
• Galimidi, Rachel P. and Klein, Joshua S., el al. (2015) Intra-Spike Crosslinking Overcomes Antibody Evasion by HIV-1; Cell; Vol. 160; No. 3; 433-446; PMCID PMC4401576; 10.1016/j.cell.2015.01.016
• Klein, Florian and Nogueira, Lilian, el al. (2014) Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants; Journal of Experimental Medicine; Vol. 211; No. 12; 2361-2372; PMCID PMC4235636; 10.1084/jem.20141050
• Scharf, Louise and Scheid, Johannes F., el al. (2014) Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike; Cell Reports; Vol. 7; No. 3; 785-795; PMCID PMC4109818; 10.1016/j.celrep.2014.04.001
• West, Anthony P., Jr. and Scharf, Louise, el al. (2014) Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy; Cell; Vol. 156; No. 4; 633-648; PMCID PMC4041625; 10.1016/j.cell.2014.01.052
• Wu, Yunji and West, Anthony P., Jr., el al. (2013) Structural Basis for Enhanced HIV-1 Neutralization by a Dimeric Immunoglobulin G Form of the Glycan-Recognizing Antibody 2G12; Cell Reports; Vol. 5; No. 5; 1443-1455; PMCID PMC3919625; 10.1016/j.celrep.2013.11.015
• West, A. P., Jr. and Scharf, L., el al. (2013) Computational Analysis of Anti-HIV-1 Antibody Neutralization Panel Data to Identify Potential Functional Epitope Residues; AIDS Research and Human Retroviruses; Vol. 29; No. 11; A170; 10.1089/aid.2013.1500
• McGuire, A. and Dreyer, A. M., el al. (2013) Engineering an HIV Envelope Protein to Activate Germline B Cell Receptors of Broadly Neutralizing VRC01-Class Antibodies; AIDS Research and Human Retroviruses; Vol. 29; No. 11; A6; 10.1089/aid.2013.1500
• Scharf, L. and West, A. P., el al. (2013) Structural Basis for HIV-1 gp120 Recognition by a Germ-line Version of a Broadly Neutralizing Antibody; AIDS Research and Human Retroviruses; Vol. 29; No. 11; A11-A12; 10.1089/aid.2013.1500
• Galimidi, R. P. and West, A. P., el al. (2013) Thwarting HIV Evasion of Antibody Avidity with Novel Antibody Architectures; AIDS Research and Human Retroviruses; Vol. 29; No. 11; A140-A141; 10.1089/aid.2013.1500
• Pascal, Robert A., Jr. and West, Anthony P., Jr. (2013) The reliability and utility of high reported specific rotations: reports and predictions of molecules with extremely high specific rotations, and high specific rotations suggest revision of the structures of huperzines E′ and F′; Tetrahedron; Vol. 69; No. 30; 6108-6115; 10.1016/j.tet.2013.05.059
• West, Anthony P., Jr. and Scharf, Louise, el al. (2013) Computational analysis of anti-HIV-1 antibody neutralization panel data to identify potential functional epitope residues; Proceedings of the National Academy of Sciences of the United States of America; Vol. 110; No. 26; 10598-10603; PMCID PMC3696754; 10.1073/pnas.1309215110
• Diskin, Ron and Klein, Florian, el al. (2013) Restricting HIV-1 pathways for escape using rationally designed anti–HIV-1 antibodies; Journal of Experimental Medicine; Vol. 210; No. 6; 1235-1249; PMCID PMC3674693; 10.1084/jem.20130221
• Galimidi, Rachel and West, Anthony, el al. (2013) Thwarting HIV evasion of antibody avidity with novel antibody architectures; Journal of Immunology; Vol. 190; 179.7
• Parrish, Nicholas F. and Galimidi, Rachel P., el al. (2013) Phenotypic properties of transmitted founder HIV-1; Proceedings of the National Academy of Sciences of the United States of America; Vol. 110; No. 17; 6626-6633; PMCID PMC3637789; 10.1073/pnas.1304288110
• Scharf, Louise and West, Anthony P., Jr., el al. (2013) Structural basis for HIV-1 gp120 recognition by a germ-line version of a broadly neutralizing antibody; Proceedings of the National Academy of Sciences of the United States of America; Vol. 110; No. 15; 6049-6054; PMCID PMC3625305; 10.1073/pnas.1303682110
• McGuire, Andrew T. and Hoot, Sam, el al. (2013) Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies; Journal of Experimental Medicine; Vol. 210; No. 4; 655-663; PMCID PMC3620356; 10.1084/jem.20122824
• Diskin, Ron and Sather, D. Noah, el al. (2013) Overcoming HIV pathways for escape using rationally-designed anti-HIV antibodies; Journal of Acquired Immune Deficiency Syndromes; Vol. 62; No. S1; 49-49; 10.1097/01.qai.0000429234.07501.af
• Balazs, Alejandro B. and West, Anthony P., Jr. (2012) Antibody gene transfer for HIV immunoprophylaxis; Nature Immunology; Vol. 14; No. 1; 1-5; PMCID PMC4560170; 10.1038/ni.2480
• West, A. P., Jr. and Diskin, R., el al. (2012) Structural basis for germline gene usage of a potent class of antibodies targeting the CD4 binding site of HIV-1 gp120; Retrovirology; Vol. 9; No. S2; Art. No. O33; PMCID PMC3441645; 10.1186/1742-4690-9-S2-O33
• West, Anthony P., Jr. and Diskin, Ron, el al. (2012) Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120; Proceedings of the National Academy of Sciences of the United States of America; Vol. 109; No. 30; E2983-E2090; PMCID PMC3409792; 10.1073/pnas.1208984109
• West, Anthony P., Jr. and Galimidi, Rachel P., el al. (2012) Single-Chain Fv-Based Anti-HIV Proteins: Potential and Limitations; Journal of Virology; Vol. 86; No. 1; 195-202; PMCID PMC3255864; 10.1128/JVI.05848-11
• Diskin, Ron and Scheid, Johannes F., el al. (2011) Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design; Science; Vol. 334; No. 6060; 1289-1293; PMCID PMC3232316; 10.1126/science.1213782
• Yang, Fan and West, Anthony P., Jr., el al. (2011) Crystal structure of a hemojuvelin-binding fragment of neogenin at 1.8 Å; Journal of Structural Biology; Vol. 174; No. 1; 239-244; PMCID PMC3074981; 10.1016/j.jsb.2010.10.005
• Luo, Xin M. and Lei, Margarida Y. Y., el al. (2010) Dimeric 2G12 as a Potent Protection against HIV-1; PLoS Pathogens; Vol. 6; No. 12; Art. No. e1001225; PMCID PMC3002980; 10.1371/journal.ppat.1001225
• Rao, Ping and Hayden, Matthew S., el al. (2010) IκBβ acts to inhibit and activate gene expression during the inflammatory response; Nature; Vol. 466; No. 7310; 1115-1119; PMCID PMC2946371; 10.1038/nature09283
• West, Anthony P., Jr. and Galimidi, Rachel P., el al. (2010) Evaluation of CD4-CD4i Antibody Architectures Yields Potent, Broadly Cross-Reactive Anti-Human Immunodeficiency Virus Reagents; Journal of Virology; Vol. 84; No. 1; 261-269; PMCID PMC2798438; 10.1128/JVI.01528-09
• Yang, Zhiru and West, Anthony P., Jr., el al. (2009) Crystal structure of TNFα complexed with a poxvirus MHC-related TNF binding protein; Nature Structural & Molecular Biology; Vol. 16; No. 11; 1189-1191; PMCID PMC2819277; 10.1038/nsmb.1683
• Klein, Joshua S. and Gnanapragasam, Priyanthi N. P., el al. (2009) Examination of the contributions of size and avidity to the neutralization mechanisms of the anti-HIV antibodies b12 and 4E10; Proceedings of the National Academy of Sciences of the United States of America; Vol. 106; No. 18; 7385-7390; PMCID PMC2678646; 10.1073/pnas.0811427106
• West, Anthony P., Jr. and Galimidi, Rachel P., el al. (2009) Design and Expression of a Dimeric Form of the Human Immunodeficiency Virus Type 1 Antibody 2G12 with Increased Neutralization Potency; Journal of Virology; Vol. 83; No. 1; 98-104; PMCID PMC2612297; 10.1128/JVI.01564-08
• Arnon, Tal I. and Kaiser, Jens T., el al. (2008) The Crystal Structure of CHIR-AB1: A Primordial Avian Classical Fc Receptor; Journal of Molecular Biology; Vol. 381; No. 4; 1012-1024; PMCID PMC2603183; 10.1016/j.jmb.2008.06.082
• Yang, Fan and West, Anthony P., el al. (2008) Neogenin Interacts with Hemojuvelin through Its Two Membrane-Proximal Fibronectin Type III Domains; Biochemistry; Vol. 47; No. 14; 4237-4245; PMCID PMC2819367; 10.1021/bi800036h
• Ja, William W. and West, Anthony P., Jr., el al. (2007) Extension of Drosophila melanogaster life span with a GPCR peptide inhibitor; Nature Chemical Biology; Vol. 3; No. 7; 415-419; PMCID PMC2803097; 10.1038/nchembio.2007.2
• Li, Pingwei and Huey-Tubman, Kathryn E., el al. (2007) The structure of a polyQ–anti-polyQ complex reveals binding according to a linear lattice model; Nature Structural & Molecular Biology; Vol. 14; No. 5; 381-387; 10.1038/nsmb1234
• McDermott, Lindsay C. and Freel, June A., el al. (2006) Zn-α_2-glycoprotein, an MHC Class I-Related Glycoprotein Regulator of Adipose Tissues: Modification or Abrogation of Ligand Binding by Site-Directed Mutagenesis; Biochemistry; Vol. 45; No. 7; 2035-2041; 10.1021/bi051881v
• Zhang, An-Sheng and West, Anthony P., Jr., el al. (2005) Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells; Journal of Biological Chemistry; Vol. 280; No. 40; 33885-33894; 10.1074/jbc.M506207200
• Hamburger, Agnes E. and West, Anthony P., Jr., el al. (2005) Crystal Structure of a Secreted Insect Ferritin Reveals a Symmetrical Arrangement of Heavy and Light Chains; Journal of Molecular Biology; Vol. 349; No. 3; 558-569; 10.1016/j.jmb.2005.03.074
• Delker, Silvia L. and West, Anthony P., Jr., el al. (2004) Crystallographic studies of ligand binding by Zn-α_2-glycoprotein; Journal of Structural Biology; Vol. 148; No. 2; 205-213; 10.1016/j.jsb.2004.04.009
• Hamburger, Agnes E. and West, Anthony P., Jr., el al. (2004) Crystal Structure of a Polymeric Immunoglobulin Binding Fragment of the Human Polymeric Immunoglobulin Receptor; Structure; Vol. 12; No. 11; 1925-1935; 10.1016/j.str.2004.09.006
• West, Anthony P., Jr. and Herr, Andrew B., el al. (2004) The Chicken Yolk Sac IgY Receptor, a Functional Equivalent of the Mammalian MHC-Related Fc Receptor, Is a Phospholipase A_2 Receptor Homolog; Immunity; Vol. 20; No. 5; 601-610; 10.1016/S1074-7613(04)00113-X
• Willcox, Benjamin E. and Thomas, Leonard M., el al. (2002) Crystal structure of LIR-2 (ILT4) at 1.8 Å: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18; BMC Structural Biology; Vol. 2; Art. No. 6; PMCID PMC130215; 10.1186/1472-6807-2-6
• Bennett, Melanie J. and Huey-Tubman, Kathryn E., el al. (2002) A linear lattice model for polyglutamine in CAG-expansion diseases; Proceedings of the National Academy of Sciences of the United States of America; Vol. 99; No. 18; 11634-11639; PMCID PMC129321; 10.1073/pnas.182393899
• West, Anthony P., Jr. and Giannetti, Anthony M., el al. (2001) Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites; Journal of Molecular Biology; Vol. 313; No. 2; 385-397; 10.1006/jmbi.2001.5048
• Martin, W. Lance and West, Anthony P., Jr., el al. (2001) Crystal Structure at 2.8 Å of an FcRn/Heterodimeric Fc Complex: Mechanism of pH-Dependent Binding; Molecular Cell; Vol. 7; No. 4; 867-877; 10.1016/S1097-2765(01)00230-1
• West, Anthony P., Jr. and Llamas, Lynda L., el al. (2001) Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan; Proceedings of the National Academy of Sciences of the United States of America; Vol. 98; No. 7; 3744-3749; PMCID PMC31123; 10.1073/pnas.051625298
• West, Anthony P., Jr. and Bennett, Melanie J., el al. (2000) Comparison of the Interactions of Transferrin Receptor and Transferrin Receptor 2 with Transferrin and the Hereditary Hemochromatosis Protein HFE; Journal of Biological Chemistry; Vol. 275; No. 49; 38135-38138; 10.1074/jbc.C000664200
• Chapman, Tara L. and Heikema, Astrid P., el al. (2000) Crystal Structure and Ligand Binding Properties of the D1D2 Region of the Inhibitory Receptor LIR-1 (ILT2); Immunity; Vol. 13; No. 5; 727-736; 10.1016/S1074-7613(00)00071-6
• West, Anthony P., Jr. and Bjorkman, Pamela J. (2000) Crystal Structure and Immunoglobulin G Binding Properties of the Human Major Histocompatibility Complex-Related Fc Receptor; Biochemistry; Vol. 39; No. 32; 9698-9708; 10.1021/bi000749m
• Lebrón, José A. and West, Anthony P., Jr., el al. (1999) The hemochromatosis protein HFE competes with transferrin for binding to the transferrin receptor; Journal of Molecular Biology; Vol. 294; No. 1; 239-245; 10.1006/jmbi.1999.3252
• West, Anthony P., Jr. and Bjorkman, Pamela J., el al. (1997) Expression and Circular Dichroism Studies of the Extracellular Domain of the alpha Subunit of the Nicotinic Acetylcholine Receptor; Journal of Biological Chemistry; Vol. 272; No. 41; 25468-25473; 10.1074/jbc.272.41.25468
• Mecozzi, Sandro and West, Anthony P., Jr., el al. (1996) Cation-pi interactions in aromatics of biological and medicinal interest: Electrostatic potential surfaces as a useful qualitative guide; Proceedings of the National Academy of Sciences of the United States of America; Vol. 93; No. 20; 10566-10571; PMCID PMC38193