- Wang, Zijun; Barnes, Christopher O.; et el. (2020) A
broadly neutralizing macaque monoclonal antibody against the HIV-1
V3-Glycan patch; eLife; Vol. 9; Art. No. e61991; PMCID PMC7577740;
10.7554/eLife.61991
- Ladinsky, Mark S.; Gnanapragasam, Priyanthi N. P.; et el. (2020) Electron
tomography visualization of HIV-1 fusion with target cells using fusion
inhibitors to trap the pre-hairpin intermediate; eLife; Vol. 9; Art.
No. e58411; PMCID PMC7394545; 10.7554/eLife.58411
- Escolano, Amelia; West, Anthony P., Jr.; et el. (2019) Immunization
expands B cells specific to HIV-1 V3 glycan in mice and macaques;
Nature; Vol. 570; No. 7762; 468-473; PMCID PMC6657810; 10.1038/s41586-019-1250-z
- Gristick, Harry; van Schooten, Jelle; et el. (2018) Engineering
HIV Immunogens to Elicit IOMA-like Antibodies Targeting the CD4 Binding
Site; AIDS Research and Human Retroviruses; Vol. 34; No. S1; 59; 10.1089/aid.2018.5000.abstracts
- Escolano, Amelia; Gristick, Harry B.; et el. (2018) Sequential
Immunization Strategies to Elicit HIV-1 bNAbs in Animal Models With a
Polyclonal B Cell Repertoire; AIDS Research and Human Retroviruses;
Vol. 34; No. S1; 331; 10.1089/aid.2018.5000.abstracts
- Mendoza, Pilar; West, Anthony P., Jr.; et el. (2018) Combination
therapy with anti-HIV-1 antibodies maintains viral suppression;
Nature; Vol. 561; No. 7724; 479-484; PMCID PMC6166473; 10.1038/s41586-018-0531-2
- Caskey, Marina; West, Anthony P., Jr.; et el. (2017) Antibody
10-1074 suppresses viremia in HIV-1-infected individuals; Nature
Medicine; Vol. 23; No. 2; 185-191; PMCID PMC5467219; 10.1038/nm.4268
- Gristick, Harry B.; von Boehmer, Lotta; et el. (2016) Natively
glycosylated HIV-1 Env structure reveals new mode for antibody
recognition of the CD4-binding site; Nature Structural &
Molecular Biology; Vol. 23; No. 10; 906-915; PMCID PMC5127623; 10.1038/nsmb.3291
- Gristick, Harry; von Boehmer, Lotta; et el. (2016) Structure
of a Natively-glycosylated HIV-1 Env Reveals a New Mode for VH1-2
Antibody Recognition of the CD4 Binding Site Relevant to Vaccine
Design; AIDS Research and Human Retroviruses; Vol. 32; No. Suppl. 1;
62
- Scharf, Louise; West, Anthony P. , Jr.; et el. (2016) Structural
basis for germline antibody recognition of HIV-1 immunogens; eLife;
Vol. 5; Art. No. e13783; PMCID PMC4811768; 10.7554/eLife.13783
- Davenport, Yunji W.; West, Anthony P.; et el. (2016) Structure
of an HIV-2 gp120 in complex with CD4; Journal of Virology; Vol. 90;
No. 4; 2112-2118; PMCID PMC4733984; 10.1128/JVI.02678-15
- Yoon, Hyejin; Macke, Jennifer; et el. (2015) CATNAP:
a tool to compile, analyze and tally neutralizing antibody panels;
Nucleic Acids Research; Vol. 43; No. W1; W213-W219; PMCID PMC4489231; 10.1093/nar/gkv404
- Barbian, Hannah J.; Galimidi, Rachel P.; et el. (2015) Neutralization
Properties of Simian Immunodeficiency Viruses Infecting Chimpanzees and
Gorillas; mBio; Vol. 6; No. 2; Art. No. e00296; PMCID PMC4453581; 10.1128/mBio.00296-15
- Galimidi, Rachel P.; Klein, Joshua S.; et el. (2015) Intra-Spike
Crosslinking Overcomes Antibody Evasion by HIV-1; Cell; Vol. 160;
No. 3; 433-446; PMCID PMC4401576; 10.1016/j.cell.2015.01.016
- Klein, Florian; Nogueira, Lilian; et el. (2014) Enhanced
HIV-1 immunotherapy by commonly arising antibodies that target virus
escape variants; Journal of Experimental Medicine; Vol. 211; No. 12;
2361-2372; PMCID PMC4235636; 10.1084/jem.20141050
- Scharf, Louise; Scheid, Johannes F.; et el. (2014) Antibody
8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope
Spike; Cell Reports; Vol. 7; No. 3; 785-795; PMCID PMC4109818; 10.1016/j.celrep.2014.04.001
- West, Anthony P., Jr.; Scharf, Louise; et el. (2014) Structural
Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy;
Cell; Vol. 156; No. 4; 633-648; PMCID PMC4041625; 10.1016/j.cell.2014.01.052
- Wu, Yunji; West, Anthony P., Jr.; et el. (2013) Structural
Basis for Enhanced HIV-1 Neutralization by a Dimeric Immunoglobulin G
Form of the Glycan-Recognizing Antibody 2G12; Cell Reports; Vol. 5;
No. 5; 1443-1455; PMCID PMC3919625; 10.1016/j.celrep.2013.11.015
- West, A. P., Jr.; Scharf, L.; et el. (2013) Computational
Analysis of Anti-HIV-1 Antibody Neutralization Panel Data to Identify
Potential Functional Epitope Residues; AIDS Research and Human
Retroviruses; Vol. 29; No. 11; A170; 10.1089/aid.2013.1500
- McGuire, A.; Dreyer, A. M.; et el. (2013) Engineering
an HIV Envelope Protein to Activate Germline B Cell Receptors of Broadly
Neutralizing VRC01-Class Antibodies; AIDS Research and Human
Retroviruses; Vol. 29; No. 11; A6; 10.1089/aid.2013.1500
- Scharf, L.; West, A. P.; et el. (2013) Structural
Basis for HIV-1 gp120 Recognition by a Germ-line Version of a Broadly
Neutralizing Antibody; AIDS Research and Human Retroviruses; Vol.
29; No. 11; A11-A12; 10.1089/aid.2013.1500
- Galimidi, R. P.; West, A. P.; et el. (2013) Thwarting
HIV Evasion of Antibody Avidity with Novel Antibody Architectures;
AIDS Research and Human Retroviruses; Vol. 29; No. 11; A140-A141; 10.1089/aid.2013.1500
- Pascal, Robert A., Jr. and West, Anthony P., Jr. (2013) The
reliability and utility of high reported specific rotations: reports and
predictions of molecules with extremely high specific rotations, and
high specific rotations suggest revision of the structures of huperzines
E′ and F′; Tetrahedron; Vol. 69; No. 30; 6108-6115; 10.1016/j.tet.2013.05.059
- West, Anthony P., Jr.; Scharf, Louise; et el. (2013) Computational
analysis of anti-HIV-1 antibody neutralization panel data to identify
potential functional epitope residues; Proceedings of the National
Academy of Sciences of the United States of America; Vol. 110; No. 26;
10598-10603; PMCID PMC3696754; 10.1073/pnas.1309215110
- Diskin, Ron; Klein, Florian; et el. (2013) Restricting
HIV-1 pathways for escape using rationally designed anti–HIV-1
antibodies; Journal of Experimental Medicine; Vol. 210; No. 6;
1235-1249; PMCID PMC3674693; 10.1084/jem.20130221
- Galimidi, Rachel; West, Anthony; et el. (2013) Thwarting
HIV evasion of antibody avidity with novel antibody architectures;
Journal of Immunology; Vol. 190; 179.7
- Parrish, Nicholas F.; Galimidi, Rachel P.; et el. (2013) Phenotypic
properties of transmitted founder HIV-1; Proceedings of the National
Academy of Sciences of the United States of America; Vol. 110; No. 17;
6626-6633; PMCID PMC3637789; 10.1073/pnas.1304288110
- Scharf, Louise; West, Anthony P., Jr.; et el. (2013) Structural
basis for HIV-1 gp120 recognition by a germ-line version of a broadly
neutralizing antibody; Proceedings of the National Academy of
Sciences of the United States of America; Vol. 110; No. 15; 6049-6054;
PMCID PMC3625305; 10.1073/pnas.1303682110
- McGuire, Andrew T.; Hoot, Sam; et el. (2013) Engineering
HIV envelope protein to activate germline B cell receptors of broadly
neutralizing anti-CD4 binding site antibodies; Journal of
Experimental Medicine; Vol. 210; No. 4; 655-663; PMCID PMC3620356; 10.1084/jem.20122824
- Diskin, Ron; Sather, D. Noah; et el. (2013) Overcoming
HIV pathways for escape using rationally-designed anti-HIV
antibodies; Journal of Acquired Immune Deficiency Syndromes; Vol.
62; No. S1; 49-49; 10.1097/01.qai.0000429234.07501.af
- Balazs, Alejandro B. and West, Anthony P., Jr. (2012) Antibody
gene transfer for HIV immunoprophylaxis; Nature Immunology; Vol. 14;
No. 1; 1-5; PMCID PMC4560170; 10.1038/ni.2480
- West, A. P., Jr.; Diskin, R.; et el. (2012) Structural
basis for germline gene usage of a potent class of antibodies targeting
the CD4 binding site of HIV-1 gp120; Retrovirology; Vol. 9; No. S2;
Art. No. O33; PMCID PMC3441645; 10.1186/1742-4690-9-S2-O33
- West, Anthony P., Jr.; Diskin, Ron; et el. (2012) Structural
basis for germ-line gene usage of a potent class of antibodies targeting
the CD4-binding site of HIV-1 gp120; Proceedings of the National
Academy of Sciences of the United States of America; Vol. 109; No. 30;
E2983-E2090; PMCID PMC3409792; 10.1073/pnas.1208984109
- West, Anthony P., Jr.; Galimidi, Rachel P.; et el. (2012) Single-Chain
Fv-Based Anti-HIV Proteins: Potential and Limitations; Journal of
Virology; Vol. 86; No. 1; 195-202; PMCID PMC3255864; 10.1128/JVI.05848-11
- Diskin, Ron; Scheid, Johannes F.; et el. (2011) Increasing
the Potency and Breadth of an HIV Antibody by Using Structure-Based
Rational Design; Science; Vol. 334; No. 6060; 1289-1293; PMCID
PMC3232316; 10.1126/science.1213782
- Yang, Fan; West, Anthony P., Jr.; et el. (2011) Crystal
structure of a hemojuvelin-binding fragment of neogenin at 1.8 Å;
Journal of Structural Biology; Vol. 174; No. 1; 239-244; PMCID
PMC3074981; 10.1016/j.jsb.2010.10.005
- Luo, Xin M.; Lei, Margarida Y. Y.; et el. (2010) Dimeric
2G12 as a Potent Protection against HIV-1; PLoS Pathogens; Vol. 6;
No. 12; Art. No. e1001225; PMCID PMC3002980; 10.1371/journal.ppat.1001225
- Rao, Ping; Hayden, Matthew S.; et el. (2010) IκBβ
acts to inhibit and activate gene expression during the inflammatory
response; Nature; Vol. 466; No. 7310; 1115-1119; PMCID PMC2946371;
10.1038/nature09283
- West, Anthony P., Jr.; Galimidi, Rachel P.; et el. (2010) Evaluation
of CD4-CD4i Antibody Architectures Yields Potent, Broadly Cross-Reactive
Anti-Human Immunodeficiency Virus Reagents; Journal of Virology;
Vol. 84; No. 1; 261-269; PMCID PMC2798438; 10.1128/JVI.01528-09
- Yang, Zhiru; West, Anthony P., Jr.; et el. (2009) Crystal
structure of TNFα complexed with a poxvirus MHC-related TNF binding
protein; Nature Structural & Molecular Biology; Vol. 16; No. 11;
1189-1191; PMCID PMC2819277; 10.1038/nsmb.1683
- Klein, Joshua S.; Gnanapragasam, Priyanthi N. P.; et el. (2009) Examination
of the contributions of size and avidity to the neutralization
mechanisms of the anti-HIV antibodies b12 and 4E10; Proceedings of
the National Academy of Sciences of the United States of America; Vol.
106; No. 18; 7385-7390; PMCID PMC2678646; 10.1073/pnas.0811427106
- West, Anthony P., Jr.; Galimidi, Rachel P.; et el. (2009) Design and
Expression of a Dimeric Form of the Human Immunodeficiency Virus Type 1
Antibody 2G12 with Increased Neutralization Potency; Journal of
Virology; Vol. 83; No. 1; 98-104; PMCID PMC2612297; 10.1128/JVI.01564-08
- Arnon, Tal I.; Kaiser, Jens T.; et el. (2008) The Crystal
Structure of CHIR-AB1: A Primordial Avian Classical Fc Receptor;
Journal of Molecular Biology; Vol. 381; No. 4; 1012-1024; PMCID
PMC2603183; 10.1016/j.jmb.2008.06.082
- Yang, Fan; West, Anthony P.; et el. (2008) Neogenin
Interacts with Hemojuvelin through Its Two Membrane-Proximal Fibronectin
Type III Domains; Biochemistry; Vol. 47; No. 14; 4237-4245; PMCID
PMC2819367; 10.1021/bi800036h
- Ja, William W.; West, Anthony P., Jr.; et el. (2007) Extension
of Drosophila melanogaster life span with a GPCR peptide inhibitor;
Nature Chemical Biology; Vol. 3; No. 7; 415-419; PMCID PMC2803097; 10.1038/nchembio.2007.2
- Li, Pingwei; Huey-Tubman, Kathryn E.; et el. (2007) The
structure of a polyQ–anti-polyQ complex reveals binding according to a
linear lattice model; Nature Structural & Molecular Biology;
Vol. 14; No. 5; 381-387; 10.1038/nsmb1234
- McDermott, Lindsay C.; Freel, June A.; et el. (2006) Zn-α_2-glycoprotein,
an MHC Class I-Related Glycoprotein Regulator of Adipose Tissues:
Modification or Abrogation of Ligand Binding by Site-Directed
Mutagenesis; Biochemistry; Vol. 45; No. 7; 2035-2041; 10.1021/bi051881v
- Zhang, An-Sheng; West, Anthony P., Jr.; et el. (2005) Interaction
of hemojuvelin with neogenin results in iron accumulation in human
embryonic kidney 293 cells; Journal of Biological Chemistry; Vol.
280; No. 40; 33885-33894; 10.1074/jbc.M506207200
- Hamburger, Agnes E.; West, Anthony P., Jr.; et el. (2005) Crystal
Structure of a Secreted Insect Ferritin Reveals a Symmetrical
Arrangement of Heavy and Light Chains; Journal of Molecular Biology;
Vol. 349; No. 3; 558-569; 10.1016/j.jmb.2005.03.074
- Hamburger, Agnes E.; West, Anthony P., Jr.; et el. (2004) Crystal
Structure of a Polymeric Immunoglobulin Binding Fragment of the Human
Polymeric Immunoglobulin Receptor; Structure; Vol. 12; No. 11;
1925-1935; 10.1016/j.str.2004.09.006
- Delker, Silvia L.; West, Anthony P., Jr.; et el. (2004) Crystallographic
studies of ligand binding by Zn-α_2-glycoprotein; Journal of
Structural Biology; Vol. 148; No. 2; 205-213; 10.1016/j.jsb.2004.04.009
- West, Anthony P., Jr.; Herr, Andrew B.; et el. (2004) The
Chicken Yolk Sac IgY Receptor, a Functional Equivalent of the Mammalian
MHC-Related Fc Receptor, Is a Phospholipase A_2 Receptor Homolog;
Immunity; Vol. 20; No. 5; 601-610; 10.1016/S1074-7613(04)00113-X
- Willcox, Benjamin E.; Thomas, Leonard M.; et el. (2002) Crystal
structure of LIR-2 (ILT4) at 1.8 Å: differences from LIR-1 (ILT2) in
regions implicated in the binding of the Human Cytomegalovirus class I
MHC homolog UL18; BMC Structural Biology; Vol. 2; Art. No. 6; PMCID
PMC130215; 10.1186/1472-6807-2-6
- Bennett, Melanie J.; Huey-Tubman, Kathryn E.; et el. (2002) A
linear lattice model for polyglutamine in CAG-expansion diseases;
Proceedings of the National Academy of Sciences of the United States of
America; Vol. 99; No. 18; 11634-11639; PMCID PMC129321; 10.1073/pnas.182393899
- West, Anthony P., Jr.; Giannetti, Anthony M.; et el. (2001) Mutational
analysis of the transferrin receptor reveals overlapping HFE and
transferrin binding sites; Journal of Molecular Biology; Vol. 313;
No. 2; 385-397; 10.1006/jmbi.2001.5048
- Martin, W. Lance; West, Anthony P., Jr.; et el. (2001) Crystal
Structure at 2.8 Å of an FcRn/Heterodimeric Fc Complex: Mechanism of
pH-Dependent Binding; Molecular Cell; Vol. 7; No. 4; 867-877; 10.1016/S1097-2765(01)00230-1
- West, Anthony P., Jr.; Llamas, Lynda L.; et el. (2001) Crystal
structure of the ectodomain of Methuselah, a Drosophila G
protein-coupled receptor associated with extended lifespan;
Proceedings of the National Academy of Sciences of the United States of
America; Vol. 98; No. 7; 3744-3749; PMCID PMC31123; 10.1073/pnas.051625298
- West, Anthony P., Jr.; Bennett, Melanie J.; et el. (2000) Comparison
of the Interactions of Transferrin Receptor and Transferrin Receptor 2
with Transferrin and the Hereditary Hemochromatosis Protein HFE;
Journal of Biological Chemistry; Vol. 275; No. 49; 38135-38138; 10.1074/jbc.C000664200
- Chapman, Tara L.; Heikema, Astrid P.; et el. (2000) Crystal
Structure and Ligand Binding Properties of the D1D2 Region of the
Inhibitory Receptor LIR-1 (ILT2); Immunity; Vol. 13; No. 5; 727-736;
10.1016/S1074-7613(00)00071-6
- West, Anthony P., Jr. and Bjorkman, Pamela J. (2000) Crystal
Structure and Immunoglobulin G Binding Properties of the Human Major
Histocompatibility Complex-Related Fc Receptor; Biochemistry; Vol.
39; No. 32; 9698-9708; 10.1021/bi000749m
- Lebrón, José A.; West, Anthony P., Jr.; et el. (1999) The
hemochromatosis protein HFE competes with transferrin for binding to the
transferrin receptor; Journal of Molecular Biology; Vol. 294; No. 1;
239-245; 10.1006/jmbi.1999.3252
- West, Anthony P., Jr.; Bjorkman, Pamela J.; et el. (1997) Expression
and Circular Dichroism Studies of the Extracellular Domain of the alpha
Subunit of the Nicotinic Acetylcholine Receptor; Journal of
Biological Chemistry; Vol. 272; No. 41; 25468-25473; 10.1074/jbc.272.41.25468
- Mecozzi, Sandro; West, Anthony P., Jr.; et el. (1996) Cation-pi
interactions in aromatics of biological and medicinal interest:
Electrostatic potential surfaces as a useful qualitative guide;
Proceedings of the National Academy of Sciences of the United States of
America; Vol. 93; No. 20; 10566-10571; PMCID PMC38193