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Five enzymes of the Arg/N-degron pathway form a targeting complex: The concept of superchanneling
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Gid10 as an alternative N-recognin of the Pro/N-degron pathway
Proceedings of the National Academy of Sciences of the United States of America;
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Varshavsky, Alexander
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On the cause of sleep: Protein fragments, the concept of sentinels, and links to epilepsy
Proceedings of the National Academy of Sciences of the United States of America;
Vol.
116;
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Varshavsky, Alexander
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N-degron and C-degron pathways of protein degradation
Proceedings of the National Academy of Sciences of the United States of America;
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Formyl-methionine as an N-degron of a eukaryotic N-end rule pathway
Science;
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Understanding the Pro/N-end rule pathway
Nature Chemical Biology;
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A reference-based protein degradation assay without global translation inhibitors
Journal of Biological Chemistry;
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Varshavsky, Alexander
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The Ubiquitin System, Autophagy, and Regulated Protein Degradation
Annual Review of Biochemistry;
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86;
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Control of Hsp90 chaperone and its clients by N-terminal acetylation and the N-end rule pathway
Proceedings of the National Academy of Sciences of the United States of America;
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Analyzing N-terminal Arginylation Through the Use of Peptide Arrays and Degradation Assays
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Degradation of Serotonin N-Acetyltransferase, a Circadian Regulator, by the N-end Rule Pathway
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Liat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeats
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Varshavsky, Alexander
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Discovery of the Biology of the Ubiquitin System
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The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments
Proceedings of the National Academy of Sciences of the United States of America;
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Varshavsky, Alexander
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The Ubiquitin System, an Immense Realm
Annual Review of Biochemistry;
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The N-end rule pathway and regulation by proteolysis
Protein Science;
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The N-end rule pathway controls multiple functions during Arabidopsis shoot and leaf development
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Glutamine-Specific N-Terminal Amidase, a Component of the N-End Rule Pathway
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Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase
Proceedings of the National Academy of Sciences of the United States of America;
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Varshavsky, Alexander
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Discovery of cellular regulation by protein degradation
Journal of Biological Chemistry;
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Hwang, Cheol-Sang; Varshavsky, Alexander
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Regulation of peptide import through phosphorylation of Ubr1, the ubiquitin ligase of the N-end rule pathway
Proceedings of the National Academy of Sciences of the United States of America;
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Varshavsky, Alexander
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The N-end rule at atomic resolution
Nature Structural & Molecular Biology;
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Substrate-binding sites of UBR1, the ubiquitin ligase of the N-end rule pathway
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The N-end rule pathway is a sensor of heme
Proceedings of the National Academy of Sciences of the United States of America;
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Varshavsky, Alexander
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Targeting the absence: Homozygous DNA deletions as immutable signposts for cancer therapy
Proceedings of the National Academy of Sciences of the United States of America;
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Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway
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A Family of Mammalian E3 Ubiquitin Ligases That Contain the UBR Box Motif and Recognize N-Degrons
Molecular and Cellular Biology;
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The N-end rule and regulation of apoptosis
Nature Cell Biology;
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An Essential Role of N-Terminal Arginylation in Cardiovascular Development
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RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: A negative feedback circuit
Proceedings of the National Academy of Sciences of the United States of America;
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The ubiquitin system
Nature Medicine;
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Detecting and Measuring Cotranslational Protein Degradation in Vivo
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The Ubiquitin System and the N-End Rule Pathway
Biological Chemistry;
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RGS4 is arginylated and degraded by the N-end rule pathway in vitro
Journal of Biological Chemistry;
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Physical association of ubiquitin ligases and the 26S proteasome
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Bivalent Inhibitor of the N-end Rule Pathway
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The mouse and human genes encoding the recognition component of the N-end rule pathway
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Codominant interference, antieffectors, and multitarget drugs
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The ubiquitin system
Trends in Biochemical Sciences;
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The N-end rule pathway of protein degradation
Genes to Cells;
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The N-end rule: Functions, mysteries, uses
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Using ubiquitin to follow the metabolic fate of a protein
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An Essential Yeast Gene Encoding a Homolog of Ubiquitin-activating Enzyme
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Yeast N-terminal Amidase: a new enzyme and component of the N-end rule pathway
Journal of Biological Chemistry;
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Codominance and toxins: A path to drugs of nearly unlimited selectivity
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Methotrexate Inhibits Proteolysis of Dihydrofolate Reductase by the N-end Rule Pathway
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The N-end Rule
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Split ubiquitin as a sensor of protein interactions in vivo
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Degradation of Gα by the N-End Rule Pathway
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Ubiquitin-assisted dissection of protein transport across membranes
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A yeast protein similar to bacterial two-component regulators
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N-recognin/Ubc2 interactions in the N-end rule pathway
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Varshavsky, Alexander
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The N-end rule
Cell;
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A gene encoding a putative tyrosine phosphatase suppresses lethality of an N-end rule-dependent mutant
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Ubiquitin as a degradation signal
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The N-end rule in bacteria
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The short-lived MATα2 transcriptional regulator is ubiquitinated in vivo
Proceedings of the National Academy of Sciences of the United States of America;
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88;
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Baker, Rohan T.; Varshavsky, Alexander
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Inhibition of the N-end rule pathway in living cells
Proceedings of the National Academy of Sciences of the United States of America;
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Varshavsky, Alexander
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Naming a targeting signal
Cell;
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UBA 1: an essential yeast gene encoding ubiquitin-activating enzyme
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Universality and Structure of the N-end Rule
Journal of Biological Chemistry;
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A DNA binding protein that recognizes oligo(dA)•oligo(dT) tracts
EMBO Journal;
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Bachmair, Andreas; Varshavsky, Alexander
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The degradation signal in a short-lived protein
Cell;
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Targeting of proteins for degradation
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The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme
Science;
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Bartel, Bonnie; Varshavsky, Alexander
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Hypersensitivity to heavy water: A new conditional phenotype
Cell;
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Varshavsky, Alexander; Bachmair, Andreas et al.
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N-end rule of selective protein turnover: mechanistic aspects and functional implications
Biochemical Society Transactions;
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Solomon, Mark J.; Varshavsky, Alexander
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A nuclease-hypersensitive region forms de novo after chromosome replication
Molecular and Cellular Biology;
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Jentsch, Stefan; McGrath, John P. et al.
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The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme
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The yeast ubiquitin genes: a family of natural gene fusions
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Post-separation detection of nucleic acids and proteins by neutron activation
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In vivo half-life of a protein is a function of its amino-terminal residue
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Enhancement of immunoblot sensitivity by heating of hydrated filters
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A mammalian high mobility group protein recognizes any stretch of six A·T base pairs in duplex DNA
Proceedings of the National Academy of Sciences of the United States of America;
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Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells
Proceedings of the National Academy of Sciences of the United States of America;
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83;
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Solomon, Mark J.; Varshavsky, Alexander
(1985)
Formaldehyde-mediated DNA-protein crosslinking: A probe for in vivo chromatin structures
Proceedings of the National Academy of Sciences of the United States of America;
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Varshavsky, Alexander
(1983)
Do stalled replication forks synthesize a specific alarmone?
Journal of Theoretical Biology;
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Snapka, Robert M.; Varshavsky, Alexander
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Loss of unstably amplified dihydrofolate reductase genes from mouse cells is greatly accelerated by hydroxyurea
Proceedings of the National Academy of Sciences of the United States of America;
Vol.
80;
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Barsoum, James; Varshavsky, Alexander
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Mitogenic hormones and tumor promoters greatly increase the incidence of colony-forming cells bearing amplified dihydrofolate reductase genes
Proceedings of the National Academy of Sciences of the United States of America;
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80;
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Levinger, Louis; Barsoum, James et al.
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Two-dimensional hybridization mapping of nucleosomes: Comparison of DNA and protein patterns
Journal of Molecular Biology;
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Varshavsky, A. J.; Bakayev, V. V. et al.
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On the structure of cellular and viral chromatin
Philosophical Transactions of the Royal Society of London. B, Biological Sciences;
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On the Structure of Eukaryotic, Prokaryotic, and Viral Chromatin
Cold Spring Harbor Symposia on Quantitative Biology;
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Varshavsky, A. J.; Nedospasov, S. A. et al.
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Histone-like proteins in the purified Escherichia coli deoxyribonucleoprotein
Nucleic Acids Research;
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Bakayev, V. V.; Bakayeva, T. G. et al.
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Nucleosomes and subnucleosomes: heterogeneity and composition
Cell;
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Varshavsky, A. J.; Bakayev, V. V. et al.
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Minichromosome of simian virus 40: presence of histone HI
Nucleic Acids Research;
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3;
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Varshavsky, Alexander J.; Bakayev, Valery V. et al.
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Studies on Chromatin. Free DNA in Sheared Chromatin
European Journal of Biochemistry;
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66;
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Varshavsky, A. J.; Bakayev, V. V. et al.
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Heterogeneity of chromatin subunits in vitro and location of histone H1
Nucleic Acids Research;
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3;
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Varshavsky, A. J.; Bakayev, V. V.
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Studies on chromatin. III. v-Bodies and Free DNA in Chromatin Lacking Histone H1
Molecular Biology Reports;
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2;
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Varshavsky, A. J.; Bakayev, V. V.
(1975)
Studies on chromatin. IV. Evidence for a toroidal shape of chromatin subunits
Molecular Biology Reports;
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2;
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3;
Varshavsky, A. J.; Georgiev, G. P.
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Studies on chromatin. V. A model for the structure of chromatin subunit
Molecular Biology Reports;
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2;
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Varshavsky, A. J.; Ilyin, Yu. V. et al.
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Very long stretches of free DNA in chromatin
Nature;
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Histone-histone proximity in chromatin as seen by imidoester cross-linking
Molecular Biology Reports;
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1;
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6;
Georgiev, Georgiy P.; Varshavsky, Alexandr Ja. et al.
(1974)
On the Structural Organization of the Transcriptional Unit in Animal Chromosomes
Cold Spring Harbor Symposia on Quantitative Biology;
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38;
Varshavsky, A. J.; Ilyin, Yu. V. et al.
(1973)
Long molecules of free DNA in the sheared chromatin preparation
Molecular Biology Reports;
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1;
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4;
Varshavsky, Alexander J.; Georgiev, Georgii P.
(1973)
Redistribution of histones during unfolding of chromosomal DNA
Molecular Biology Reports;
Vol.
1;
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3;