[ { "id": "authors:9b1s3-3cn39", "collection": "authors", "collection_id": "9b1s3-3cn39", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20230526-663046000.25", "type": "book_section", "title": "A Monolithic 3D Magnetic Sensor in 65nm CMOS with <10\u03bcTrms Noise and 14.8\u03bcW Power", "book_title": "2023 IEEE Custom Integrated Circuits Conference (CICC)", "author": [ { "family_name": "Sharma", "given_name": "Saransh", "orcid": "0000-0002-5052-4932", "clpid": "Sharma-Saransh" }, { "family_name": "Melton", "given_name": "Hayward", "clpid": "Melton-Hayward" }, { "family_name": "Edmonds", "given_name": "Liliana", "orcid": "0000-0002-2068-3334", "clpid": "Edmonds-Liliana" }, { "family_name": "Addington", "given_name": "Olivia", "clpid": "Addington-Olivia" }, { "family_name": "Shapiro", "given_name": "Mikhail", "orcid": "0000-0002-0291-4215", "clpid": "Shapiro-M-G" }, { "family_name": "Emami", "given_name": "Azita", "orcid": "0000-0002-6945-9958", "clpid": "Emami-A" } ], "abstract": "Magnetic sensors have become increasingly ubiquitous as they constitute an integral part of several fast-growing sectors such as automotive, navigation, robotics, medical devices and consumer electronics. Due to their compatibility with the standard CMOS process, Hall magnetic sensors are widely used. However, one of the key challenges of CMOS-based Hall sensors is their relatively low sensitivity, which is inevitable given the low Hall coefficient of Si. For better sensitivity, Hall sensors are biased at higher current levels which hinders their widescale use in low-power bioelectronics and other power-constrained applications. Another challenge is the difficulty in implementing high-sensitivity vertical Hall elements in planar CMOS processes for 3D sensing. This is often overcome by using ferromagnetic materials that require additional and expensive steps during fabrication, thus increasing the cost.", "doi": "10.1109/cicc57935.2023.10121313", "isbn": "9798350399486", "publisher": "IEEE", "place_of_publication": "Piscataway, NJ", "publication_date": "2023-04" }, { "id": "authors:9qzyb-cv806", "collection": "authors", "collection_id": "9qzyb-cv806", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20200417-102219007", "type": "book_section", "title": "3D Surgical Alignment with 100\u00b5m Resolution Using Magnetic-Field Gradient-Based Localization", "book_title": "2020 IEEE International Solid-State Circuits Conference", "author": [ { "family_name": "Sharma", "given_name": "Saransh", "clpid": "Sharma-S" }, { "family_name": "Ding", "given_name": "Grace", "clpid": "Ding-Grace" }, { "family_name": "Telikicherla", "given_name": "Aditya", "clpid": "Telikicherla-A" }, { "family_name": "Aghlmand", "given_name": "Fatemeh", "clpid": "Aghlmand-F" }, { "family_name": "Talkhooncheh", "given_name": "Arian Hashemi", "clpid": "Talkhooncheh-A-H" }, { "family_name": "Wang", "given_name": "Minwo", "clpid": "Wang-Minwo" }, { "family_name": "Shapiro", "given_name": "Mikhail G.", "orcid": "0000-0002-0291-4215", "clpid": "Shapiro-M-G" }, { "family_name": "Emami", "given_name": "Azita", "orcid": "0000-0002-6945-9958", "clpid": "Emami-A" } ], "abstract": "Substantial advances in the field of surgery have taken place in recent years, which aim at decreasing patient morbidity through innovations in endoscopy, optical imaging, laparoscopic and robotic technologies. However, real-time imaging and navigation during high precision surgery necessitates the use of X-Ray fluoroscopy with most existing technologies to achieve precise localization. Intramedullary (IM) nailing is a common example of such high precision orthopedic surgery, which requires insertion of a nail into the medullary canal of a fractured bone followed by locking screws [1]. Proximal screw locking is performed using a mechanical guide, which is not possible for distal locking owing to the deformation (\u224815mm) caused during insertion [2]. Freehand technique is typically used to localize distal holes, in which the surgical drill is aligned with the hole axis through fluoroscopic imaging. This process is time-consuming and exposes the patient and surgical team to high ionizing radiation. Various other methods, which reduce or eliminate irradiation during distal locking, are not widely used. This is attributed to their lack of compensation for significant deformation of the nail, added requirements such as computing systems, extra robotic arms, CT images, sophisticated hardware and software that require training for the surgeon and staff.", "doi": "10.1109/isscc19947.2020.9063108", "isbn": "9781728132051", "publisher": "IEEE", "place_of_publication": "Piscataway, NJ", "publication_date": "2020-02", "pages": "318-320" }, { "id": "authors:zardb-z8g35", "collection": "authors", "collection_id": "zardb-z8g35", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20190822-134051942", "type": "book_section", "title": "Using the Gouy phase shift to estimate gas vesicle concentrations in salmonella (Conference Presentation)", "book_title": "Quantitative Phase Imaging V", "author": [ { "family_name": "Nadeau", "given_name": "Jay L.", "orcid": "0000-0001-5258-0076", "clpid": "Nadeau-J-L" }, { "family_name": "Bedrossian", "given_name": "Manuel", "clpid": "Bedrossian-M" }, { "family_name": "Farhadi", "given_name": "Arash", "orcid": "0000-0001-9137-8559", "clpid": "Farhadi-A" }, { "family_name": "Ho", "given_name": "Gabrielle", "orcid": "0000-0002-8511-5549", "clpid": "Ho-Gabrielle-H" }, { "family_name": "Shapiro", "given_name": "Mikhail", "orcid": "0000-0002-0291-4215", "clpid": "Shapiro-M-G" } ], "contributor": [ { "family_name": "Popescu", "given_name": "Gabriel", "clpid": "Popescu-G" }, { "family_name": "Park", "given_name": "YongKuen", "clpid": "Park-YongKuen" } ], "abstract": "As light, or any other wave, converges into focus, the apparent wavelength of the wave increases as the phase velocity surpasses the speed of propagation in that medium. For a Gaussian beam, this causes a phase change \u0394\u03d5 equal to \u00b1\u03c0. This phenomenon, named the Gouy phase shift, can be observed when a plane wave is refracted by a lens and caused to come into focus. The location where this phase shift occurs in the axial direction is the focal length of the lens. Many biological structures are curved and thus can be modeled as lenslets. Bacterial cells have a radius of curvature that can be readily determined from high resolution images. A plane wave passing through them would be refracted and converge at some point after interacting with the bacterium. Altering the refractive index of the cells will change the effective focal length of the lenslet and thus the location of the Gouy phase shift. We have previously shown that purified gas vesicles (GVs) can be transfected into bacterial cells, altering the refractive index in large areas of the cell. In this work, we use off-axis digital holographic microscopy to measure the effect of GVs on the index of refraction of Salmonella cells and relate this to changes in the Gouy phase shift. By observing the location of this phase shift relative to the location of the bacterium, the GV concentration within the cell can be estimated, highlighting the potential of GVs as a quantitative contrast agent for QPI.", "doi": "10.1117/12.2508953", "isbn": "9781510624160", "publisher": "Society of Photo-optical Instrumentation Engineers (SPIE)", "place_of_publication": "Bellingham, WA", "publication_date": "2019-03-04", "pages": "Art. No. 1088706" }, { "id": "authors:6jb2t-7kb61", "collection": "authors", "collection_id": "6jb2t-7kb61", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180109-145625927", "type": "book_section", "title": "Engineering acoustic biomolecules as dynamic molecular sensors for ultrasound", "book_title": "2017 IEEE International Ultrasonics Symposium (IUS)", "author": [ { "family_name": "Lakshmanan", "given_name": "Anupama", "orcid": "0000-0002-6702-837X", "clpid": "Lakshmanan-A" }, { "family_name": "Nety", "given_name": "Suchita P.", "clpid": "Nety-Suchita-P" }, { "family_name": "Maresca", "given_name": "David", "orcid": "0000-0002-4921-6406", "clpid": "Maresca-D" }, { "family_name": "Shapiro", "given_name": "Mikhail G.", "orcid": "0000-0002-0291-4215", "clpid": "Shapiro-M-G" } ], "abstract": "Ultrasound is currently limited in its ability to image dynamic molecular and cellular processes due to the lack of appropriate contrast agents. Gas Vesicles (GVs) - hollow protein nanostructures isolated from buoyant microbes, have emerged as a new class of nanoscale imaging agents for ultrasound (Shapiro et al., Nat. Nano. 2014). The genetic encodability of these acoustic biomolecules provides a unique platform for engineering mechanical and functional properties at the protein level. Recently, we demonstrated that removal or sequence modification of a key GV shell protein results in nanostructures with enhanced non-linear contrast as well as tunable collapse pressures for multiplexed imaging (Lakshmanan et al., ACS Nano 2016; Maresca et al., Appl. Phys. Lett. 2017). Now, we extend this platform to engineer GVs whose ultrasound signals change dynamically in response to the activity of specific molecules in their environment. In particular, we set out to produce GVs that change their non-linear ultrasound contrast in response to specific proteases, an important class of enzymes underlying homeostatic and disease processes and a target of drug discovery.", "doi": "10.1109/ULTSYM.2017.8092227", "isbn": "978-1-5386-3383-0", "publisher": "IEEE", "place_of_publication": "Piscataway, NJ", "publication_date": "2017-09" }, { "id": "authors:fd3c9-3cd51", "collection": "authors", "collection_id": "fd3c9-3cd51", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180109-124523829", "type": "book_section", "title": "Elucidating the biophysical mechanisms of ultrasonic neuromodulation", "book_title": "2017 IEEE International Ultrasonics Symposium (IUS)", "author": [ { "family_name": "Yoo", "given_name": "Sangjin", "orcid": "0000-0002-0449-4242", "clpid": "Yoo-Sangjin" }, { "family_name": "Sato", "given_name": "Tomo", "clpid": "Sato-Tomokazu-F" }, { "family_name": "Tsao", "given_name": "Doris Y.", "orcid": "0000-0003-1083-1919", "clpid": "Tsao-D-Y" }, { "family_name": "Shapiro", "given_name": "Mikhail", "orcid": "0000-0002-0291-4215", "clpid": "Shapiro-M-G" } ], "abstract": "Ultrasonic neuromodulation is a promising technology in the field of basic and translational neuroscience because it can control neural activity within the skull without invasive surgery. In particular, low frequency ultrasound has been widely reported to elicit neural excitation and behavior in a number of animal models and humans. However, the cellular and molecular mechanisms of ultrasonic neuromodulation are not yet elucidated, impeding their use in neuroscience and potential clinical translation. To bridge this gap, we investigated the mechanisms of ultrasonic neuromodulation at the levels of single cells and intact organisms.", "doi": "10.1109/ULTSYM.2017.8092954", "isbn": "978-1-5386-3383-0", "publisher": "IEEE", "place_of_publication": "Piscataway, NJ", "publication_date": "2017-09" }, { "id": "authors:qxpz2-7rq78", "collection": "authors", "collection_id": "qxpz2-7rq78", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20130410-132453635", "type": "book_section", "title": "Directed Evolution of Protein-Based Neurotransmitter Sensors for MRI", "book_title": "Chemical Neurobiology : Methods and Protocols", "author": [ { "family_name": "Romero", "given_name": "Philip A.", "orcid": "0000-0002-2586-7263", "clpid": "Romero-P-A" }, { "family_name": "Shapiro", "given_name": "Mikhail G.", "orcid": "0000-0002-0291-4215", "clpid": "Shapiro-M-G" }, { "family_name": "Arnold", "given_name": "Frances H.", "orcid": "0000-0002-4027-364X", "clpid": "Arnold-F-H" }, { "family_name": "Jasanoff", "given_name": "Alan", "orcid": "0000-0002-2834-6359", "clpid": "Jasanoff-A" } ], "contributor": [ { "family_name": "Banghart", "given_name": "Matthew R.", "clpid": "Banghart-M-R" } ], "abstract": "The production of contrast agents sensitive to neuronal signaling events is a rate-limiting step in the development of molecular-level functional magnetic resonance imaging (molecular fMRI) approaches for studying the brain. High-throughput generation and evaluation of potential probes are possible using techniques for macromolecular engineering of protein-based contrast agents. In an initial exploration of this strategy, we used the method of directed evolution to identify mutants of a bacterial heme protein that allowed detection of the neurotransmitter dopamine in vitro and in living animals. The directed evolution method involves successive cycles of mutagenesis and screening that could be generalized to produce contrast agents sensitive to a variety of molecular targets in the nervous system.", "doi": "10.1007/978-1-62703-345-9_14", "pmcid": "PMC3818115", "isbn": "978-1-62703-344-2", "publisher": "Springer", "place_of_publication": "New York, NY", "publication_date": "2013", "pages": "193-205" } ]