@article{https://authors.library.caltech.edu/records/npa54-0gt95, title = "Dynamic stability of Sgt2 enables selective and privileged client handover in a chaperone triad", journal = "Nature Communications", url = "https://authors.library.caltech.edu/records/npa54-0gt95", id = "record", issn = "2041-1723", doi = "10.1038/s41467-023-44260-5", volume = "15", pmcid = "PMC10761869" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20230519-1772000.24, title = "Dodecamer assembly of a metazoan AAA⁺ chaperone couples substrate extraction to refolding", journal = "Science Advances", url = "https://resolver.caltech.edu/CaltechAUTHORS:20230519-1772000.24", id = "record", issn = "2375-2548", doi = "10.1126/sciadv.adf5336", volume = "9", pmcid = "PMC10171807" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20230206-9587900.32, title = "Role of Hsp70 in Post-Translational Protein Targeting: Tail-Anchored Membrane Proteins and Beyond", journal = "International Journal of Molecular Sciences", url = "https://resolver.caltech.edu/CaltechAUTHORS:20230206-9587900.32", id = "record", issn = "1422-0067", doi = "10.3390/ijms24021170", volume = "24", pmcid = "PMC9866221" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20220816-373597000, title = "System-wide analyses reveal essential roles of N-terminal protein modification in bacterial membrane integrity", journal = "iScience", url = "https://resolver.caltech.edu/CaltechAUTHORS:20220816-373597000", id = "record", issn = "2589-0042", doi = "10.1016/j.isci.2022.104756", volume = "25", pmcid = "PMC9356101" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20220614-222089000, title = "Ribosome profiling reveals multiple roles of SecA in cotranslational protein export", journal = "Nature Communications", url = "https://resolver.caltech.edu/CaltechAUTHORS:20220614-222089000", id = "record", issn = "2041-1723", doi = "10.1038/s41467-022-31061-5", volume = "13", pmcid = "PMC9192764" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20220310-121624000, title = "Ribosome-nascent Chain Interaction Regulates N-terminal Protein Modification", journal = "Journal of Molecular Biology", url = "https://resolver.caltech.edu/CaltechAUTHORS:20220310-121624000", id = "record", issn = "0022-2836", doi = "10.1016/j.jmb.2022.167535", volume = "434", pmcid = "PMC9126151" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20220225-724347000, title = "Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting", journal = "Science", url = "https://resolver.caltech.edu/CaltechAUTHORS:20220225-724347000", id = "record", issn = "0036-8075", doi = "10.1126/science.abl6459", volume = "375", pmcid = "PMC7612438" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20220112-394479800, title = "Fidelity of Cotranslational Protein Targeting to the Endoplasmic Reticulum", journal = "International Journal of Molecular Sciences", url = "https://resolver.caltech.edu/CaltechAUTHORS:20220112-394479800", id = "record", issn = "1422-0067", doi = "10.3390/ijms23010281", volume = "23", pmcid = "PMC8745203" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20211022-170110641, title = "Subunit cooperation in the Get1/2 receptor promotes tail-anchored membrane protein insertion", journal = "Journal of Cell Biology", url = "https://resolver.caltech.edu/CaltechAUTHORS:20211022-170110641", id = "record", issn = "0021-9525", doi = "10.1083/jcb.202103079", volume = "220" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20210713-201044719, title = "Chloroplast SRP43 autonomously protects chlorophyll biosynthesis proteins against heat shock", journal = "Nature Plants", url = "https://resolver.caltech.edu/CaltechAUTHORS:20210713-201044719", id = "record", issn = "2055-026X", doi = "10.1038/s41477-021-00994-y", volume = "7", pmcid = "PMC8879858" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20210819-225523366, title = "Molecular mechanism of cargo recognition and handover by the mammalian signal recognition particle", journal = "Cell Reports", url = "https://resolver.caltech.edu/CaltechAUTHORS:20210819-225523366", id = "record", issn = "2211-1247", doi = "10.1016/j.celrep.2021.109350", volume = "36", pmcid = "PMC8330425" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20200109-143242552, title = "Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER", journal = "Science Advances", url = "https://resolver.caltech.edu/CaltechAUTHORS:20200109-143242552", id = "record", issn = "2375-2548", doi = "10.1126/sciadv.abg0942", volume = "7", pmcid = "PMC8139590" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20210317-150527513, title = "J-domain proteins promote client relay from Hsp70 during tail-anchored membrane protein targeting", journal = "Journal of Biological Chemistry", url = "https://resolver.caltech.edu/CaltechAUTHORS:20210317-150527513", id = "record", issn = "0021-9258", doi = "10.1016/j.jbc.2021.100546", volume = "296" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20201113-100152867, title = "A Disorder-to-Order Transition Activates an ATP-Independent Membrane Protein Chaperone", journal = "Journal of Molecular Biology", url = "https://resolver.caltech.edu/CaltechAUTHORS:20201113-100152867", id = "record", issn = "0022-2836", doi = "10.1016/j.jmb.2020.11.007", volume = "432", pmcid = "PMC7780713" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20201117-112556236, title = "A ribosome-associated chaperone enables substrate triage in a cotranslational protein targeting complex", journal = "Nature Communications", url = "https://resolver.caltech.edu/CaltechAUTHORS:20201117-112556236", id = "record", issn = "2041-1723", doi = "10.1038/s41467-020-19548-5", volume = "11", pmcid = "PMC7673040" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20201009-132404547, title = "Nascent Protein Selection and Triage at the Ribosome Exit Site", journal = "FASEB Journal", url = "https://resolver.caltech.edu/CaltechAUTHORS:20201009-132404547", id = "record", issn = "0892-6638", doi = "10.1096/fasebj.2020.34.s1.00156", volume = "34" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20201008-143954486, title = "Timing and Specificity of Cotranslational Nascent Protein Modification in Bacteria", journal = "FASEB Journal", url = "https://resolver.caltech.edu/CaltechAUTHORS:20201008-143954486", id = "record", issn = "0892-6638", doi = "10.1096/fasebj.2020.34.s1.04322", volume = "34" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20191031-125530361, title = "Timing and specificity of cotranslational nascent protein modification in bacteria", journal = "Proceedings of the National Academy of Sciences of the United States of America", url = "https://resolver.caltech.edu/CaltechAUTHORS:20191031-125530361", id = "record", issn = "0027-8424", doi = "10.1073/pnas.1912264116", volume = "116", pmcid = "PMC6859321" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20191002-094951031, title = "Guiding tail-anchored membrane proteins to the endoplasmic reticulum in a chaperone cascade", journal = "Journal of Biological Chemistry", url = "https://resolver.caltech.edu/CaltechAUTHORS:20191002-094951031", id = "record", issn = "0021-9258", doi = "10.1074/jbc.rev119.006197", volume = "294", pmcid = "PMC6851334" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20190919-142731254, title = "A molecular recognition feature mediates ribosome-induced SRP-receptor assembly during protein targeting", journal = "Journal of Cell Biology", url = "https://resolver.caltech.edu/CaltechAUTHORS:20190919-142731254", id = "record", issn = "0021-9525", doi = "10.1083/jcb.201901001", volume = "218", pmcid = "PMC6781444" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20190801-131335661, title = "The molecular mechanism of cotranslational membrane protein recognition and targeting by SecA", journal = "Nature Structural \& Molecular Biology", url = "https://resolver.caltech.edu/CaltechAUTHORS:20190801-131335661", id = "record", issn = "1545-9985", doi = "10.1038/s41594-019-0297-8", volume = "26", pmcid = "PMC6858539" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20190102-135256811, title = "A Chaperone Lid Ensures Efficient and Privileged Client Transfer during Tail-Anchored Protein Targeting", journal = "Cell Reports", url = "https://resolver.caltech.edu/CaltechAUTHORS:20190102-135256811", id = "record", issn = "2211-1247", doi = "10.1016/j.celrep.2018.12.035", volume = "26", pmcid = "PMC6689467" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20181008-095135080, title = "In vitro Assays for Targeting and Insertion of Tail‐Anchored Proteins Into the ER Membrane", journal = "Current Protocols in Cell Biology", url = "https://resolver.caltech.edu/CaltechAUTHORS:20181008-095135080", id = "record", issn = "1934-2616", doi = "10.1002/cpcb.63", volume = "81", pmcid = "PMC6263799" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20180709-130553195, title = "Substrate relay in an Hsp70‐cochaperone cascade safeguards tail‐anchored membrane protein targeting", journal = "EMBO Journal", url = "https://resolver.caltech.edu/CaltechAUTHORS:20180709-130553195", id = "record", issn = "0261-4189", doi = "10.15252/embj.201899264", volume = "37", pmcid = "PMC6092619" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20180530-150151067, title = "Sequential activation of human signal recognition particle by the ribosome and signal sequence drives efficient protein targeting", journal = "Proceedings of the National Academy of Sciences of the United States of America", url = "https://resolver.caltech.edu/CaltechAUTHORS:20180530-150151067", id = "record", issn = "0027-8424", doi = "10.1073/pnas.1802252115", volume = "115", pmcid = "PMC6004459" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20180423-092135973, title = "Two Distinct Sites of client protein interaction with the chaperone cpSRP43", journal = "Journal of Biological Chemistry", url = "https://resolver.caltech.edu/CaltechAUTHORS:20180423-092135973", id = "record", issn = "0021-9258", doi = "10.1074/jbc.RA118.002215", volume = "293", pmcid = "PMC5995501" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20180326-131741830, title = "Structure of a prehandover mammalian ribosomal SRP•SRP receptor targeting complex", journal = "Science", url = "https://resolver.caltech.edu/CaltechAUTHORS:20180326-131741830", id = "record", issn = "0036-8075", doi = "10.1126/science.aar7924", volume = "360", pmcid = "PMC6309883" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20180326-161145347, title = "Chloroplast SRP43 acts as a chaperone for glutamyl-tRNA reductase, the rate-limiting enzyme in tetrapyrrole biosynthesis", journal = "Proceedings of the National Academy of Sciences of the United States of America", url = "https://resolver.caltech.edu/CaltechAUTHORS:20180326-161145347", id = "record", issn = "0027-8424", doi = "10.1073/pnas.1719645115", volume = "115", pmcid = "PMC5899456" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20180523-143936913, title = "Two-Step Membrane Binding by the Bacterial SRP Receptor Enables Efficient and Accurate Co-Translational Protein Targeting", journal = "Biophysical Journal", url = "https://resolver.caltech.edu/CaltechAUTHORS:20180523-143936913", id = "record", issn = "0006-3495", doi = "10.1016/j.bpj.2017.11.1170", volume = "114" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20180510-133648234, title = "A Protean Clamp Guides Membrane Targeting of Tail-Anchored Proteins", journal = "Biophysical Journal", url = "https://resolver.caltech.edu/CaltechAUTHORS:20180510-133648234", id = "record", issn = "0006-3495", doi = "10.1016/j.bpj.2017.11.3022", volume = "114" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20180510-112234591, title = "Co-translational Targeting by Signal Recognition Particle Activates Only after Cytosolic Exposure of Signal Sequence", journal = "Biophysical Journal", url = "https://resolver.caltech.edu/CaltechAUTHORS:20180510-112234591", id = "record", issn = "0006-3495", doi = "10.1016/j.bpj.2017.11.425", volume = "114" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20180112-075000705, title = "Dynamics of Membrane Protein-Chaperone Interaction", journal = "Protein Science", url = "https://resolver.caltech.edu/CaltechAUTHORS:20180112-075000705", id = "record", issn = "0961-8368", doi = "10.1002/pro.3349", volume = "26" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20170925-085525865, title = "SecA mediates cotranslational targeting and translocation of an inner membrane protein", journal = "Journal of Cell Biology", url = "https://resolver.caltech.edu/CaltechAUTHORS:20170925-085525865", id = "record", issn = "0021-9525", doi = "10.1083/jcb.201704036", volume = "216", pmcid = "PMC5674894" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20170926-110202110, title = "A protean clamp guides membrane targeting of tail-anchored proteins", journal = "Proceedings of the National Academy of Sciences of the United States of America", url = "https://resolver.caltech.edu/CaltechAUTHORS:20170926-110202110", id = "record", issn = "0027-8424", doi = "10.1073/pnas.1708731114", volume = "114", pmcid = "PMC5642712" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20171012-133314474, title = "Mechanisms of Tail-Anchored Membrane Protein Targeting and Insertion", journal = "Annual Review of Cell and Developmental Biology", url = "https://resolver.caltech.edu/CaltechAUTHORS:20171012-133314474", id = "record", issn = "1081-0706", doi = "10.1146/annurev-cellbio-100616-060839", volume = "33", pmcid = "PMC6343671" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20170731-091633412, title = "Two-step membrane binding by the bacterial SRP receptor enable efficient and accurate Co-translational protein targeting", journal = "eLife", url = "https://resolver.caltech.edu/CaltechAUTHORS:20170731-091633412", id = "record", issn = "2050-084X", doi = "10.7554/eLife.25885", volume = "6", pmcid = "PMC5533587" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20170522-110612032, title = "Structure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome", journal = "Nature Communications", url = "https://resolver.caltech.edu/CaltechAUTHORS:20170522-110612032", id = "record", issn = "2041-1723", doi = "10.1038/ncomms15470", volume = "8", pmcid = "PMC5454536" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20161205-134337068, title = "Anionic Phospholipids and the Albino3 Translocase Activate Signal Recognition Particle-Receptor Interaction during Light-harvesting Chlorophyll a/b-binding Protein Targeting", journal = "Journal of Biological Chemistry", url = "https://resolver.caltech.edu/CaltechAUTHORS:20161205-134337068", id = "record", issn = "0021-9258", doi = "10.1074/jbc.M116.752956", volume = "292", pmcid = "PMC5217697" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20161205-103747522, title = "Co-evolution of two GTPases enables efficient protein targeting in an RNA-less chloroplast Signal Recognition Particle pathway", journal = "Journal of Biological Chemistry", url = "https://resolver.caltech.edu/CaltechAUTHORS:20161205-103747522", id = "record", issn = "0021-9258", doi = "10.1074/jbc.M116.752931", volume = "292", pmcid = "PMC5217696" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20161212-104646015, title = "Multiple selection filters ensure accurate tail-anchored membrane protein targeting", journal = "eLife", url = "https://resolver.caltech.edu/CaltechAUTHORS:20161212-104646015", id = "record", issn = "2050-084X", doi = "10.7554/eLife.21301", volume = "5", pmcid = "PMC5214336" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20160919-100630353, title = "ATPase and GTPase Tangos Drive Intracellular Protein Transport", journal = "Trends in Biochemical Sciences", url = "https://resolver.caltech.edu/CaltechAUTHORS:20160919-100630353", id = "record", issn = "0968-0004", doi = "10.1016/j.tibs.2016.08.012", volume = "41", pmcid = "PMC5627767" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20161117-073554872, title = "Analyzing Single-Molecule Protein Transportation Experiments via Hierarchical Hidden Markov Models", journal = "Journal of the American Statistical Association", url = "https://resolver.caltech.edu/CaltechAUTHORS:20161117-073554872", id = "record", issn = "0162-1459", doi = "10.1080/01621459.2016.1140050", volume = "111", pmcid = "PMC5606165" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20160525-094720168, title = "A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy", journal = "EBioMedicine", url = "https://resolver.caltech.edu/CaltechAUTHORS:20160525-094720168", id = "record", issn = "2352-3964", doi = "10.1016/j.ebiom.2016.02.043", volume = "6", pmcid = "PMC4856754" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20160308-073550753, title = "Conformational dynamics of a membrane protein chaperone enables spatially regulated substrate capture and release", journal = "Proceedings of the National Academy of Sciences of the United States of America", url = "https://resolver.caltech.edu/CaltechAUTHORS:20160308-073550753", id = "record", issn = "0027-8424", doi = "10.1073/pnas.1524777113", volume = "113", pmcid = "PMC4812700" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20160606-080929408, title = "Inversion of Signal Sequence Topology during Membrane Integration", journal = "Biophysical Journal", url = "https://resolver.caltech.edu/CaltechAUTHORS:20160606-080929408", id = "record", issn = "0006-3495", doi = "10.1016/j.bpj.2015.11.1252", volume = "110" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20151019-101737280, title = "Mechanism of assembly of a substrate-transfer complex during tail-anchored protein targeting", journal = "Journal of Biological Chemistry", url = "https://resolver.caltech.edu/CaltechAUTHORS:20151019-101737280", id = "record", issn = "0021-9258", doi = "10.1074/jbc.M115.677328", volume = "290", pmcid = "PMC4705998" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20150609-122913362, title = "Regulation by a chaperone improves substrate selectivity during cotranslational protein targeting", journal = "Proceedings of the National Academy of Sciences of the United States of America", url = "https://resolver.caltech.edu/CaltechAUTHORS:20150609-122913362", id = "record", issn = "0027-8424", doi = "10.1073/pnas.1422594112", volume = "112", pmcid = "PMC4485088" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20150318-091732909, title = "Ribosome–SRP–FtsY cotranslational targeting complex in the closed state", journal = "Proceedings of the National Academy of Sciences of the United States of America", url = "https://resolver.caltech.edu/CaltechAUTHORS:20150318-091732909", id = "record", issn = "0027-8424", doi = "10.1073/pnas.1424453112", volume = "112", pmcid = "PMC4386334" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20151106-080405216, title = "Distinct Membrane Association Modes Facilitate Co-Translational Protein Targeting", journal = "Biophysical Journal", url = "https://resolver.caltech.edu/CaltechAUTHORS:20151106-080405216", id = "record", issn = "0006-3495", doi = "10.1016/j.bpj.2014.11.1401", volume = "108" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20151204-105119596, title = "Inter-Domain Dynamics of a Novel Chaperone Enables Effective Capture of Membrane Protein Substrates", journal = "Biophysical Journal", url = "https://resolver.caltech.edu/CaltechAUTHORS:20151204-105119596", id = "record", issn = "0006-3495", doi = "10.1016/j.bpj.2014.11.323", volume = "108" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20141105-102115424, title = "Differential gradients of interaction affinities drive efficient targeting and recycling in the GET pathway", journal = "Proceedings of the National Academy of Sciences of the United States of America", url = "https://resolver.caltech.edu/CaltechAUTHORS:20141105-102115424", id = "record", issn = "0027-8424", doi = "10.1073/pnas.1411284111", volume = "111", pmcid = "PMC4246279" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20140106-100007866, title = "Co-translational protein targeting to the bacterial membrane", journal = "Biochimica et Biophysica Acta - Molecular Cell Research", url = "https://resolver.caltech.edu/CaltechAUTHORS:20140106-100007866", id = "record", issn = "0167-4889", doi = "10.1016/j.bbamcr.2013.10.013", volume = "1843", pmcid = "PMC3999308" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20140613-090320700, title = "Regulation of cargo recognition, commitment, and unloading drives cotranslational protein targeting", journal = "Journal of Cell Biology", url = "https://resolver.caltech.edu/CaltechAUTHORS:20140613-090320700", id = "record", issn = "0021-9525", doi = "10.1083/jcb.201311028", volume = "205", pmcid = "PMC4050729" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20140728-091816472, title = "Inefficient Translocation of Preproinsulin Contributes to Pancreatic β Cell Failure and Late-onset Diabetes", journal = "Journal of Biological Chemistry", url = "https://resolver.caltech.edu/CaltechAUTHORS:20140728-091816472", id = "record", issn = "0021-9258", doi = "10.1074/jbc.M114.562355", volume = "289", pmcid = "PMC4047398" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20140605-104144841, title = "Fidelity of Cotranslational Protein Targeting by the Signal Recognition Particle", journal = "Annual Review of Biophysics", url = "https://resolver.caltech.edu/CaltechAUTHORS:20140605-104144841", id = "record", issn = "1936-122X", doi = "10.1146/annurev-biophys-051013-022653", volume = "43", pmcid = "PMC4444370" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20140423-093035077, title = "Crystal structure of ATP-bound Get3–Get4–Get5 complex reveals regulation of Get3 by Get4", journal = "Nature Structural \& Molecular Biology", url = "https://resolver.caltech.edu/CaltechAUTHORS:20140423-093035077", id = "record", issn = "1545-9985", doi = "10.1038/nsmb.2813", volume = "21", pmcid = "PMC4386898" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20150204-084954787, title = "The structure of a tail-anchor membrane protein-binding complex reveals the regulation of Get3 by Get4", journal = "FASEB Journal", url = "https://resolver.caltech.edu/CaltechAUTHORS:20150204-084954787", id = "record", issn = "0892-6638", volume = "28" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20150205-131139873, title = "Regulation of mitochondrial fission by MiD51", journal = "FASEB Journal", url = "https://resolver.caltech.edu/CaltechAUTHORS:20150205-131139873", id = "record", issn = "0892-6638", volume = "28" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20140214-120458864, title = "The Mitochondrial Fission Receptor MiD51 Requires ADP as a Cofactor", journal = "Structure", url = "https://resolver.caltech.edu/CaltechAUTHORS:20140214-120458864", id = "record", issn = "0969-2126", doi = "10.1016/j.str.2014.01.001", volume = "22", pmcid = "PMC4066849" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20140124-141625084, title = "Molecular Mechanism of GTPase Activation at the Signal Recognition Particle (SRP) RNA Distal End", journal = "Journal of Biological Chemistry", url = "https://resolver.caltech.edu/CaltechAUTHORS:20140124-141625084", id = "record", issn = "0021-9258", doi = "10.1074/jbc.M113.513614", volume = "288", pmcid = "PMC3868752" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20131223-080921779, title = "The Structural Basis of FtsY Recruitment and GTPase Activation by SRP RNA", journal = "Molecular Cell", url = "https://resolver.caltech.edu/CaltechAUTHORS:20131223-080921779", id = "record", issn = "1097-2765", doi = "10.1016/j.molcel.2013.10.005", volume = "52", pmcid = "PMC3910249" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20130826-105419836, title = "Signal Recognition Particle: An Essential Protein-Targeting Machine", journal = "Annual Review of Biochemistry", url = "https://resolver.caltech.edu/CaltechAUTHORS:20130826-105419836", id = "record", issn = "0066-4154", doi = "10.1146/annurev-biochem-072711-164732", volume = "82", pmcid = "PMC3805129" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20130621-133910862, title = "Mechanism of an ATP-independent Protein Disaggregase. II. Distinct Molecular Interactions Drive Multiple Steps During Aggregate Disassembly", journal = "Journal of Biological Chemistry", url = "https://resolver.caltech.edu/CaltechAUTHORS:20130621-133910862", id = "record", issn = "0021-9258", doi = "10.1074/jbc.M113.462861", volume = "288", pmcid = "PMC3650381" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20130621-085950473, title = "Mechanism of an ATP-independent Protein Disaggregase - I. Structure of a Membrane Protein Aggregate Reveals a Mechanism of Recognition by its Chaperone", journal = "Journal of Biological Chemistry", url = "https://resolver.caltech.edu/CaltechAUTHORS:20130621-085950473", id = "record", issn = "0021-9258", doi = "10.1074/jbc.M113.462812", volume = "288", pmcid = "PMC3650380" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20130628-090524393, title = "Precise timing of ATPase activation drives targeting of tail-anchored proteins", journal = "Proceedings of the National Academy of Sciences of the United States of America", url = "https://resolver.caltech.edu/CaltechAUTHORS:20130628-090524393", id = "record", issn = "0027-8424", doi = "10.1073/pnas.1222054110", volume = "110", pmcid = "PMC3651441" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20130625-102457328, title = "Structural basis of signal sequence surveillance and selection by the SRP–FtsY complex", journal = "Nature Structural \& Molecular Biology", url = "https://resolver.caltech.edu/CaltechAUTHORS:20130625-102457328", id = "record", issn = "1545-9985", doi = "10.1038/nsmb.2546", volume = "20", pmcid = "PMC3874396" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20130711-133423197, title = "Activated GTPase movement on an RNA scaffold drives cotranslational protein targeting", journal = "FASEB Journal", url = "https://resolver.caltech.edu/CaltechAUTHORS:20130711-133423197", id = "record", issn = "0892-6638", volume = "27" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20130711-103448215, title = "The ATPase Cycle of the Tail-Anchored Protein Chaperone Get3", journal = "FASEB Journal", url = "https://resolver.caltech.edu/CaltechAUTHORS:20130711-103448215", id = "record", issn = "0892-6638", volume = "27" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20130711-133855161, title = "GTPase and ATPase tangos during intracellular protein targeting", journal = "FASEB Journal", url = "https://resolver.caltech.edu/CaltechAUTHORS:20130711-133855161", id = "record", issn = "0892-6638", volume = "27" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20130517-081333288, title = "Cand1 Promotes Assembly of New SCF Complexes through Dynamic Exchange of F Box Proteins", journal = "Cell", url = "https://resolver.caltech.edu/CaltechAUTHORS:20130517-081333288", id = "record", issn = "0092-8674", doi = "10.1016/j.cell.2013.02.024", volume = "153", pmcid = "PMC3656483" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20130320-140650051, title = "SecYEG activates GTPases to drive the completion of cotranslational protein targeting", journal = "Journal of Cell Biology", url = "https://resolver.caltech.edu/CaltechAUTHORS:20130320-140650051", id = "record", issn = "0021-9525", doi = "10.1083/jcb.201208045", volume = "200", pmcid = "PMC3575545" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20130501-084952283, title = "Precise Timing of ATPase Activation Drives Targeting of Tail-Anchored Proteins", journal = "Biophysical Journal", url = "https://resolver.caltech.edu/CaltechAUTHORS:20130501-084952283", id = "record", issn = "0006-3495", doi = "10.1016/j.bpj.2012.11.3178", volume = "104" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20130429-084737150, title = "Activated GTPase Movement on SRP RNA Drives Cotranslational Protein Targeting", journal = "Biophysical Journal", url = "https://resolver.caltech.edu/CaltechAUTHORS:20130429-084737150", id = "record", issn = "0006-3495", doi = "10.1016/j.bpj.2012.11.2334", volume = "104" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20130722-092857106, title = "Fingerloop activates cargo delivery and unloading during cotranslational protein targeting", journal = "Molecular Biology of the Cell", url = "https://resolver.caltech.edu/CaltechAUTHORS:20130722-092857106", id = "record", issn = "1059-1524", doi = "10.1091/mbc.E12-06-0434", volume = "24", pmcid = "PMC3541965" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20130103-133200806, title = "Activated GTPase movement on an RNA scaffold drives co-translational protein targeting", journal = "Nature", url = "https://resolver.caltech.edu/CaltechAUTHORS:20130103-133200806", id = "record", issn = "0028-0836", doi = "10.1038/nature11726", volume = "492", pmcid = "PMC3531814" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20121220-150130013, title = "The cpSRP54-cpFtsY Interaction in the Chloroplast SRP Pathway", journal = "FASEB Journal", url = "https://resolver.caltech.edu/CaltechAUTHORS:20121220-150130013", id = "record", issn = "0892-6638", volume = "26" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20120502-085929510, title = "Impaired Cleavage of Preproinsulin Signal Peptide Linked to Autosomal-Dominant Diabetes", journal = "Diabetes", url = "https://resolver.caltech.edu/CaltechAUTHORS:20120502-085929510", id = "record", issn = "0012-1797", doi = "10.2337/db11-0878", volume = "61", pmcid = "PMC3314357" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20120404-070455923, title = "Translation Elongation Regulates Substrate Selection by the Signal Recognition Particle", journal = "Journal of Biological Chemistry", url = "https://resolver.caltech.edu/CaltechAUTHORS:20120404-070455923", id = "record", issn = "0021-9258", doi = "10.1074/jbc.M111.325001", volume = "287", pmcid = "PMC3293578" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20120306-072520214, title = "Novel Proteomic Tools Reveal Essential Roles of SRP and Importance of Proper Membrane Protein Biogenesis", journal = "Molecular and Cellular Proteomics", url = "https://resolver.caltech.edu/CaltechAUTHORS:20120306-072520214", id = "record", issn = "1535-9476", doi = "10.1074/mcp.M111.011585", volume = "11", pmcid = "PMC3277757" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20111116-085157884, title = "A tale of two GTPases in cotranslational protein targeting", journal = "Protein Science", url = "https://resolver.caltech.edu/CaltechAUTHORS:20111116-085157884", id = "record", issn = "0961-8368", doi = "10.1002/pro.729", volume = "20", pmcid = "PMC3267943" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20111031-102635621, title = "Site-Specific Fluorescent Labeling of Nascent Proteins on the Translating Ribosome", journal = "Journal of the American Chemical Society", url = "https://resolver.caltech.edu/CaltechAUTHORS:20111031-102635621", id = "record", issn = "0002-7863", doi = "10.1021/ja206626g", volume = "133", pmcid = "PMC3189723" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20110906-083414953, title = "Concerted Complex Assembly and GTPase Activation in the Chloroplast Signal Recognition Particle", journal = "Biochemistry", url = "https://resolver.caltech.edu/CaltechAUTHORS:20110906-083414953", id = "record", issn = "0006-2960", doi = "10.1021/bi200742a", volume = "50", pmcid = "PMC6309729" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20110425-113304294, title = "Molecular Mechanism of Co-translational Protein Targeting by the Signal Recognition Particle", journal = "Traffic", url = "https://resolver.caltech.edu/CaltechAUTHORS:20110425-113304294", id = "record", issn = "1398-9219", doi = "10.1111/j.1600-0854.2011.01171.x", volume = "12", pmcid = "PMC3077218" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20110502-112759851, title = "Synergistic actions between the SRP RNA and translating ribosome allow efficient delivery of the correct cargos during cotranslational protein targeting", journal = "RNA", url = "https://resolver.caltech.edu/CaltechAUTHORS:20110502-112759851", id = "record", issn = "1355-8382", doi = "10.1261/rna.2610411", volume = "17", pmcid = "PMC3078738" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20110511-090620791, title = "Direct visualization reveals dynamics of a transient intermediate during protein assembly", journal = "Proceedings of the National Academy of Sciences of the United States of America", url = "https://resolver.caltech.edu/CaltechAUTHORS:20110511-090620791", id = "record", issn = "0027-8424", doi = "10.1073/pnas.1019051108", volume = "108", pmcid = "PMC3081034" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20110314-100418858, title = "The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor", journal = "Science", url = "https://resolver.caltech.edu/CaltechAUTHORS:20110314-100418858", id = "record", issn = "0036-8075", doi = "10.1126/science.1196473", volume = "331", pmcid = "PMC3758919" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20110214-091234951, title = "Cryo-EM structure of the E. coli translating ribosome in complex with SRP and its receptor", journal = "Nature Structural \& Molecular Biology", url = "https://resolver.caltech.edu/CaltechAUTHORS:20110214-091234951", id = "record", issn = "1545-9985", doi = "10.1038/nsmb.1952", volume = "18", pmcid = "PMC3764645" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20100920-093243413, title = "Lipid activation of the signal recognition particle receptor provides spatial coordination of protein targeting", journal = "Journal of Cell Biology", url = "https://resolver.caltech.edu/CaltechAUTHORS:20100920-093243413", id = "record", issn = "0021-9525", doi = "10.1083/jcb.201004129", volume = "190", pmcid = "PMC2928010" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20100623-160406505, title = "ATP-independent reversal of a membrane protein aggregate by a chloroplast SRP subunit", journal = "Nature Structural \& Molecular Biology", url = "https://resolver.caltech.edu/CaltechAUTHORS:20100623-160406505", id = "record", issn = "1545-9985", doi = "10.1038/nsmb.1836", volume = "17", pmcid = "PMC2917185" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20100521-152717223, title = "Sequential Checkpoints Govern Substrate Selection During Cotranslational Protein Targeting", journal = "Science", url = "https://resolver.caltech.edu/CaltechAUTHORS:20100521-152717223", id = "record", issn = "0036-8075", doi = "10.1126/science.1186743", volume = "328", pmcid = "PMC3760334" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20100527-075322402, title = "Transient tether between the SRP RNA and SRP receptor ensures efficient cargo delivery during cotranslational protein targeting", journal = "Proceedings of the National Academy of Sciences of the United States of America", url = "https://resolver.caltech.edu/CaltechAUTHORS:20100527-075322402", id = "record", issn = "0027-8424", doi = "10.1073/pnas.1002968107", volume = "107", pmcid = "PMC2867919" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20091221-110503492, title = "Detection of sequential polyubiquitylation on a millisecond timescale", journal = "Nature", url = "https://resolver.caltech.edu/CaltechAUTHORS:20091221-110503492", id = "record", issn = "0028-0836", doi = "10.1038/nature08595", volume = "462", pmcid = "PMC2791906" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20090911-153600633, title = "A Distinct Mechanism to Achieve Efficient Signal Recognition Particle (SRP)-SRP Receptor Interaction by the Chloroplast SRP Pathway", journal = "Molecular Biology of the Cell", url = "https://resolver.caltech.edu/CaltechAUTHORS:20090911-153600633", id = "record", issn = "1059-1524", doi = "10.1091/mbc.E08-10-0989", volume = "20", pmcid = "PMC2735494" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20090916-153459576, title = "Signal Recognition Particle (SRP) and SRP Receptor: A New Paradigm for Multistate Regulatory GTPases", journal = "Biochemistry", url = "https://resolver.caltech.edu/CaltechAUTHORS:20090916-153459576", id = "record", issn = "0006-2960", doi = "10.1021/bi9006989", volume = "48", pmcid = "PMC2883566" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20090407-091223238, title = "Multiple conformational switches in a GTPase complex control co-translational protein targeting", journal = "Proceedings of the National Academy of Sciences of the United States of America", url = "https://resolver.caltech.edu/CaltechAUTHORS:20090407-091223238", id = "record", issn = "0027-8424", doi = "10.1073/pnas.0808573106", volume = "106", pmcid = "PMC2644110" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20120726-073902314, title = "Demonstration of a Multistep Mechanism for Assembly of the SRP·SRP Receptor Complex: Implications for the Catalytic Role of SRP RNA", journal = "Journal of Molecular Biology", url = "https://resolver.caltech.edu/CaltechAUTHORS:20120726-073902314", id = "record", issn = "0022-2836", doi = "10.1016/j.jmb.2008.05.049", volume = "381", pmcid = "PMC2630804" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20120726-074454154, title = "Structure of the Chloroplast Signal Recognition Particle (SRP) Receptor: Domain Arrangement Modulates SRP–Receptor Interaction", journal = "Journal of Molecular Biology", url = "https://resolver.caltech.edu/CaltechAUTHORS:20120726-074454154", id = "record", issn = "0022-2836", doi = "10.1016/j.jmb.2007.09.061", volume = "375" } @article{https://resolver.caltech.edu/CaltechAUTHORS:SHAjcb07, title = "Conformational changes in the GTPase modules of the signal reception particle and its receptor drive initiation of protein translocation", journal = "Journal of Cell Biology", url = "https://resolver.caltech.edu/CaltechAUTHORS:SHAjcb07", id = "record", issn = "0021-9525", doi = "10.1083/jcb.200702018", volume = "178", pmcid = "PMC2064468" } @article{https://resolver.caltech.edu/CaltechAUTHORS:JARmbc07, title = "Efficient Interaction between Two GTPases Allows the Chloroplast SRP Pathway to Bypass the Requirement for an SRP RNA", journal = "Molecular Biology of the Cell", url = "https://resolver.caltech.edu/CaltechAUTHORS:JARmbc07", id = "record", issn = "1059-1524", doi = "10.1091/mbc.E07-01-0037", volume = "18", pmcid = "PMC1924832" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20170131-140941855, title = "Molecular Crosstalk between the Nucleotide Specificity Determinant of the SRP GTPase and the SRP Receptor", journal = "Biochemistry", url = "https://resolver.caltech.edu/CaltechAUTHORS:20170131-140941855", id = "record", issn = "0006-2960", doi = "10.1021/bi0500980", volume = "44" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20190814-113039620, title = "Co-translational protein targeting by the signal recognition particle", journal = "FEBS Letters", url = "https://resolver.caltech.edu/CaltechAUTHORS:20190814-113039620", id = "record", issn = "0014-5793", doi = "10.1016/j.febslet.2004.11.049", volume = "579" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20190820-160532216, title = "Unraveling the interface of signal recognition particle and its receptor by using chemical cross-linking and tandem mass spectrometry", journal = "Proceedings of the National Academy of Sciences of the United States of America", url = "https://resolver.caltech.edu/CaltechAUTHORS:20190820-160532216", id = "record", issn = "0027-8424", doi = "10.1073/pnas.0407456101", volume = "101", pmcid = "PMC528904" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20190820-153826181, title = "Mechanism of Association and Reciprocal Activation of Two GTPases", journal = "PLoS Biology", url = "https://resolver.caltech.edu/CaltechAUTHORS:20190820-153826181", id = "record", issn = "1545-7885", doi = "10.1371/journal.pbio.0020320", volume = "2", pmcid = "PMC517823" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20190822-090051239, title = "Substrate twinning activates the signal recognition particle and its receptor", journal = "Nature", url = "https://resolver.caltech.edu/CaltechAUTHORS:20190822-090051239", id = "record", issn = "0028-0836", doi = "10.1038/nature02250", volume = "427" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20190918-102339005, title = "Induced nucleotide specificity in a GTPase", journal = "Proceedings of the National Academy of Sciences of the United States of America", url = "https://resolver.caltech.edu/CaltechAUTHORS:20190918-102339005", id = "record", issn = "0027-8424", doi = "10.1073/pnas.0737693100", volume = "100", pmcid = "PMC153581" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20190819-161842072, title = "Dissection of a metal-ion-mediated conformational change in Tetrahymena ribozyme catalysis", journal = "RNA", url = "https://resolver.caltech.edu/CaltechAUTHORS:20190819-161842072", id = "record", issn = "1355-8382", doi = "10.1017/s1355838202020216", volume = "8", pmcid = "PMC1370303" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20191007-081920896, title = "Role of SRP RNA in the GTPase Cycles of Ffh and FtsY", journal = "Biochemistry", url = "https://resolver.caltech.edu/CaltechAUTHORS:20191007-081920896", id = "record", issn = "0006-2960", doi = "10.1021/bi011639y", volume = "40" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20191004-154123295, title = "An unconventional origin of metal-ion rescue and inhibition in the Tetrahymena group I ribozyme reaction", journal = "RNA", url = "https://resolver.caltech.edu/CaltechAUTHORS:20191004-154123295", id = "record", issn = "1355-8382", volume = "6", pmcid = "PMC1369959" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20191004-154804302, title = "Three metal ions at the active site of the Tetrahymena group I ribozyme", journal = "Proceedings of the National Academy of Sciences of the United States of America", url = "https://resolver.caltech.edu/CaltechAUTHORS:20191004-154804302", id = "record", issn = "0027-8424", doi = "10.1073/pnas.96.22.12299", volume = "96", pmcid = "PMC22911" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20191004-161147327, title = "Protonated 2'-Aminoguanosine as a Probe of the Electrostatic Environment of the Active Site of the Tetrahymena Group I Ribozyme", journal = "Biochemistry", url = "https://resolver.caltech.edu/CaltechAUTHORS:20191004-161147327", id = "record", issn = "0006-2960", doi = "10.1021/bi9903897", volume = "38" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20190819-152022033, title = "Probing the Role of Metal Ions in RNA Catalysis:  Kinetic and Thermodynamic Characterization of a Metal Ion Interaction with the 2'-Moiety of the Guanosine Nucleophile in the Tetrahymena Group I Ribozyme", journal = "Biochemistry", url = "https://resolver.caltech.edu/CaltechAUTHORS:20190819-152022033", id = "record", issn = "0006-2960", doi = "10.1021/bi990388e", volume = "38" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20190814-142341729, title = "Enzyme kinetics and mechanism Part E: Energetics of Enzyme Catalysis", chapter = "Hydrogen bonding in enzymatic catalysis: Analysis of energetic contributions", url = "https://resolver.caltech.edu/CaltechAUTHORS:20190814-142341729", id = "record", isbn = "9780121822095", doi = "10.1016/S0076-6879(99)08013-1" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20191004-160446800, title = "The change in hydrogen bond strength accompanying charge rearrangement: Implications for enzymatic catalysis", journal = "Proceedings of the National Academy of Sciences of the United States of America", url = "https://resolver.caltech.edu/CaltechAUTHORS:20191004-160446800", id = "record", issn = "0027-8424", doi = "10.1073/pnas.93.25.14474", volume = "93", pmcid = "PMC26157" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20190814-161721487, title = "The Energetics of Hydrogen Bonds in Model Systems: Implications for Enzymatic Catalysis", journal = "Science", url = "https://resolver.caltech.edu/CaltechAUTHORS:20190814-161721487", id = "record", issn = "0036-8075", doi = "10.1126/science.272.5258.97", volume = "272" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20191002-154651520, title = "Modular mutagenesis of exons 1, 2, and 8 of a glutathione S-transferase from the Mu class. Mechanistic and structural consequences for chimeras of isoenzyme 3-3", journal = "Biochemistry", url = "https://resolver.caltech.edu/CaltechAUTHORS:20191002-154651520", id = "record", issn = "0006-2960", doi = "10.1021/bi00157a005", volume = "31" }