[ { "id": "authors:kcajz-0as09", "collection": "authors", "collection_id": "kcajz-0as09", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20190712-084951751", "type": "book_section", "title": "Beam-Steering Nanophotonic Phased-Array Neural Probes", "book_title": "CLEO: Applications and Technology 2019", "author": [ { "family_name": "Sacher", "given_name": "Wesley D.", "orcid": "0000-0003-3306-4556", "clpid": "Sacher-W-D" }, { "family_name": "Liu", "given_name": "Xinyu", "clpid": "Liu-Xinyu" }, { "family_name": "Chen", "given_name": "Fu-Der", "clpid": "Chen-Fu-Der" }, { "family_name": "Moradi-Chameh", "given_name": "Homeira", "clpid": "Moradi-Chameh-H" }, { "family_name": "Felts Almog", "given_name": "Ilan", "clpid": "Felts-Almog-I" }, { "family_name": "Lordello", "given_name": "Thomas", "clpid": "Lordello-T" }, { "family_name": "Chang", "given_name": "Michael", "clpid": "Chang-Michael" }, { "family_name": "Naderian", "given_name": "Azadeh", "clpid": "Naderian-A" }, { "family_name": "Fowler", "given_name": "Trevor M.", "clpid": "Fowler-T-M" }, { "family_name": "Segev", "given_name": "Eran", "clpid": "Segev-E" }, { "family_name": "Xue", "given_name": "Tianyuan", "clpid": "Xue-Tianyuan" }, { "family_name": "Mahallati", "given_name": "Sara", "clpid": "Mahallati-S" }, { "family_name": "Valiante", "given_name": "Taufik A.", "clpid": "Valiante-T-A" }, { "family_name": "Moreaux", "given_name": "Laurent C.", "orcid": "0000-0003-1276-5062", "clpid": "Moreaux-Laurent-C" }, { "family_name": "Poon", "given_name": "Joyce K. S.", "clpid": "Poon-J-K-S" }, { "family_name": "Roukes", "given_name": "Michael L.", "orcid": "0000-0002-2916-6026", "clpid": "Roukes-M-L" } ], "abstract": "We demonstrate the first implantable nanophotonic neural probes with integrated silicon nitride phased arrays. Coherent beam-steering is achieved in brain tissue by wavelength tuning. Beam profiles, optogenetic stimulation, and functional imaging are validated in vitro.", "doi": "10.1364/cleo_at.2019.ath4i.4", "isbn": "978-1-943580-57-6", "publisher": "Optical Society of America", "place_of_publication": "Washington, DC", "publication_date": "2019-05", "pages": "Art. No. ATh4I.4" }, { "id": "authors:5ytpp-10310", "collection": "authors", "collection_id": "5ytpp-10310", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20190712-082924197", "type": "book_section", "title": "Nanophotonic Neural Probes for in vivo Light Sheet Imaging", "book_title": "CLEO: Science and Innovations 2019", "author": [ { "family_name": "Sacher", "given_name": "Wesley D.", "orcid": "0000-0003-3306-4556", "clpid": "Sacher-W-D" }, { "family_name": "Liu", "given_name": "Xinyu", "clpid": "Liu-Xinyu" }, { "family_name": "Felts Almog", "given_name": "Ilan", "clpid": "Felts-Almog-I" }, { "family_name": "Fomenko", "given_name": "Anton", "clpid": "Fomenko-A" }, { "family_name": "Lordello", "given_name": "Thomas", "clpid": "Lordello-T" }, { "family_name": "Chen", "given_name": "Fu-Der", "clpid": "Chen-Fu-Der" }, { "family_name": "Moradi-Chameh", "given_name": "Homeira", "clpid": "Moradi-Chameh-H" }, { "family_name": "Naderian", "given_name": "Azadeh", "clpid": "Naderian-A" }, { "family_name": "Chang", "given_name": "Michael", "clpid": "Chang-Michael" }, { "family_name": "Fowler", "given_name": "Trevor M.", "clpid": "Fowler-T-M" }, { "family_name": "Valiante", "given_name": "Taufik A.", "clpid": "Valiante-T-A" }, { "family_name": "Lozano", "given_name": "Andres M.", "clpid": "Lozano-A-M" }, { "family_name": "Moreaux", "given_name": "Laurent C.", "orcid": "0000-0003-1276-5062", "clpid": "Moreaux-Laurent-C" }, { "family_name": "Poon", "given_name": "Joyce K. S.", "clpid": "Poon-J-K-S" }, { "family_name": "Roukes", "given_name": "Michael L.", "orcid": "0000-0002-2916-6026", "clpid": "Roukes-M-L" } ], "abstract": "We present implantable silicon neural probes with nanophotonic waveguide routing networks and grating emitters for light sheet imaging. Fluorescein beam profiles, fluorescent bead imaging, and fluorescence brain imaging in vivo are presented.", "doi": "10.1364/cleo_si.2019.sm4h.6", "isbn": "978-1-943580-57-6", "publisher": "Optical Society of America", "place_of_publication": "Washington, DC", "publication_date": "2019-05", "pages": "Art. No. SM4H.6" }, { "id": "authors:7f8ny-svh37", "collection": "authors", "collection_id": "7f8ny-svh37", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20190314-133521536", "type": "book_section", "title": "A 512-Pixel 3kHz-Frame-Rate Dual-Shank Lensless Filterless Single-Photon-Avalanche-Diode CMOS Neural Imaging Probe", "book_title": "2019 IEEE International Solid- State Circuits Conference - (ISSCC)", "author": [ { "family_name": "Lee", "given_name": "Changhyuk", "orcid": "0000-0002-1108-6327", "clpid": "Lee-Changhyuk" }, { "family_name": "Taal", "given_name": "Adriaan J.", "orcid": "0000-0002-1649-2826", "clpid": "Taal-A-J" }, { "family_name": "Choi", "given_name": "Jaebin", "orcid": "0000-0002-8348-7701", "clpid": "Choi-Jaebin" }, { "family_name": "Kim", "given_name": "Kukjoo", "clpid": "Kim-Kukjoo" }, { "family_name": "Tien", "given_name": "Kevin", "clpid": "Tien-Kevin" }, { "family_name": "Moreaux", "given_name": "Laurent C.", "orcid": "0000-0003-1276-5062", "clpid": "Moreaux-Laurent-C" }, { "family_name": "Roukes", "given_name": "Michael L.", "orcid": "0000-0002-2916-6026", "clpid": "Roukes-M-L" }, { "family_name": "Shepard", "given_name": "Kenneth L.", "orcid": "0000-0003-0665-6775", "clpid": "Shepard-K-L" } ], "abstract": "Optical functional neural imaging has revolutionized neuroscience with optical reporters that enable single-cell-resolved monitoring of neuronal activity in vivo. State-of-the-art microscopy methods, however, are fundamentally limited in imaging depth by absorption and scattering in tissue even with the use of the most sophisticated two-photon microscopy techniques [1]. To overcome this imaging depth problem, we develop a lens-less, optical-filter-less, shank-based image sensor array that can be inserted into the brain, allowing cellular-resolution recording at arbitrary depths with excitation provided by an external laser light source (Fig. 11.5.1). Lens-less imaging is achieved generally by giving each pixel a spatial sensitivity function, which can be introduced by near-field or far-field, phase or amplitude masking. Since probe thickness must be less than 70\u03bcm to limit tissue damage and far-field masks are characterized by distances on the order of 200\u03bcm between the mask and the detector [2], we employ a near-field amplitude mask formed by Talbot gratings in the back-end metal of the CMOS process, which gives each pixel a diffraction-grating-induced angle-sensitivity [3]. Filter-less fluorescence imaging is achieved with time-gated operation in which the excitation light source is pulsed and pixel-level time-gated circuitry collects photons only after the excitation source has been removed.", "doi": "10.1109/ISSCC.2019.8662408", "isbn": "978-1-5386-8531-0", "publisher": "IEEE", "place_of_publication": "Piscataway, NJ", "publication_date": "2019-02", "pages": "198-200" }, { "id": "authors:7mrm8-q1h27", "collection": "authors", "collection_id": "7mrm8-q1h27", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20170112-075048926", "type": "book_section", "title": "Highly Multiplexed Nanophotonic Probes With Independently Controllable Emitters for Optogenetic Brain Stimulation", "book_title": "Conference on Lasers and Electro-Optics 2016", "author": [ { "family_name": "Segev", "given_name": "Eran", "clpid": "Segev-E" }, { "family_name": "Moreaux", "given_name": "Laurent C.", "orcid": "0000-0003-1276-5062", "clpid": "Moreaux-Laurent-C" }, { "family_name": "Reimer", "given_name": "Jacob", "clpid": "Reimer-J" }, { "family_name": "Fowler", "given_name": "Trevor M.", "clpid": "Fowler-T-M" }, { "family_name": "Chi", "given_name": "Derrick", "clpid": "Chi-Derrick" }, { "family_name": "Sacher", "given_name": "Wesley D.", "orcid": "0000-0003-3306-4556", "clpid": "Sacher-W-D" }, { "family_name": "Lo", "given_name": "Maisie", "clpid": "Lo-Maisie" }, { "family_name": "Deisseroth", "given_name": "Karl", "clpid": "Deisseroth-K" }, { "family_name": "Tolias", "given_name": "Andreas S.", "clpid": "Tolias-A-S" }, { "family_name": "Faraon", "given_name": "Andrei", "orcid": "0000-0002-8141-391X", "clpid": "Faraon-A" }, { "family_name": "Roukes", "given_name": "Michael", "orcid": "0000-0002-2916-6026", "clpid": "Roukes-M-L" } ], "abstract": "We present visible-wavelength photonic probes that implement WDM method for delivery of complex illumination patterns with cellular-scale spatial resolution deep within brain tissue. Neuron activation is verified by extracellular electrical recordings, and by two-photon functional imaging.", "doi": "10.1364/CLEO_AT.2016.JTh4B.2", "isbn": "978-1-943580-11-8", "publisher": "Optical Society of America (OSA)", "place_of_publication": "Washington, DC", "publication_date": "2016-06", "pages": "Art. No. JTh4B.2" } ]