[ { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/jc95e-ezk64", "eprint_id": 121460, "eprint_status": "archive", "datestamp": "2023-08-22 20:52:41", "lastmod": "2023-10-25 17:43:39", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Hu-Jinping", "name": { "family": "Hu", "given": "Jinping" }, "orcid": "0000-0003-0415-4616" }, { "id": "Asimow-P-D", "name": { "family": "Asimow", "given": "Paul D." }, "orcid": "0000-0001-6025-8925" }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0003-0308-0942" }, { "id": "Ma-Chi-Geology", "name": { "family": "Ma", "given": "Chi" }, "orcid": "0000-0002-1828-7033" } ] }, "title": "Shock-recovered maskelynite indicates low-pressure ejection of shergottites from Mars", "ispublished": "pub", "full_text_status": "public", "keywords": "Multidisciplinary", "note": "\u00a9 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). \n\nWe thank J. Isa for characterizing the initial sample of Saddleback basalt and M. Burns and R. Oliver for expert technical help with the shock wave experiments. C. Koeberl and two anonymous reviewers are thanked for their constructive comments. \n\nThis work was funded by NASA award 80NSSC18K0532 to J.H., NSF award 1947616 to P.D.A., and NASA award 80NM0018F0612 to Y.L. California Institute of Technology (Caltech) JPL President's and Director's Fund partially supported this work. Shock wave experiments performed in the Lindhurst Laboratory for Experimental Geophysics at Caltech are supported by NSF awards 1725349 and 1829277. A portion of this project was performed at Jet Propulsion Laboratory, managed by Caltech under a contract with NASA. \n\nAuthor contributions: Conceptualization: J.H., P.D.A., and YL. Methodology: P.D.A., J.H., and Y.L. Investigation: J.H., Y.L., P.D.A., and C.M. Supervision: P.D.A. and Y.L. Writing (original draft): J.H. Writing (review and editing): J.H., P.D.A., Y.L., and C.M. \n\nData and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials. \n\nThe authors declare that they have no competing interests.\n\n
Published - sciadv.adf2906.pdf
Supplemental Material - sciadv.adf2906_sm.pdf
", "abstract": "Diaplectic feldspathic glass, commonly known as maskelynite, is a widely used impact indicator, notably for shergottites, whose shock conditions are keys to their geochemistry and launch mechanism. However, classic reverberating shock recovery experiments show maskelynitization at higher shock pressures (>30 gigapascals) than the stability field of the high-pressure minerals found in many shergottites (15 to 25 gigapascals). Most likely, differences between experimental loading paths and those appropriate for martian impacts have created this ambiguity in shergottite shock histories. Shock reverberation yields lower temperature and deviatoric stress than single-shock planetary impacts at equivalent pressure. We report the Hugoniot equation of state of a martian analog basalt and single-shock recovery experiments, indicating partial-to-complete maskelynitization at 17 to 22 gigapascals, consistent with the high-pressure minerals in maskelynitized shergottites. This pressure explains the presence of intact magmatic accessory minerals, used for geochronology in shergottites, and offers a new pressure-time profile for modeling shergottite launch, likely requiring greater origin depth.", "date": "2023-05-03", "date_type": "published", "publication": "Science Advances", "volume": "9", "number": "18", "publisher": "American Association for the Advancement of Science", "pagerange": "Art. No. adf2906", "id_number": "CaltechAUTHORS:20230519-1751000.22", "issn": "2375-2548", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20230519-1751000.22", "funders": { "items": [ { "agency": "NASA", "grant_number": "80NSSC18K0532" }, { "agency": "NSF", "grant_number": "EAR-1947616" }, { "agency": "NASA", "grant_number": "80NM0018F0612" }, { "agency": "JPL President and Director's Fund" }, { "agency": "NSF", "grant_number": "EAR-1725349" }, { "agency": "NSF", "grant_number": "EAR-1829277" }, { "agency": "NASA/JPL/Caltech" } ] }, "local_group": { "items": [ { "id": "Division-of-Geological-and-Planetary-Sciences" } ] }, "doi": "10.1126/sciadv.adf2906", "pmcid": "PMC10156110", "primary_object": { "basename": "sciadv.adf2906.pdf", "url": "https://authors.library.caltech.edu/records/jc95e-ezk64/files/sciadv.adf2906.pdf" }, "related_objects": [ { "basename": "sciadv.adf2906_sm.pdf", "url": "https://authors.library.caltech.edu/records/jc95e-ezk64/files/sciadv.adf2906_sm.pdf" } ], "resource_type": "article", "pub_year": "2023", "author_list": "Hu, Jinping; Asimow, Paul D.; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/zvkwb-erq25", "eprint_id": 118295, "eprint_status": "archive", "datestamp": "2023-08-22 18:26:26", "lastmod": "2023-10-24 23:16:30", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Scheller-Eva-L", "name": { "family": "Scheller", "given": "Eva L." }, "orcid": "0000-0002-9981-5802" }, { "id": "Razzell-Hollis-Joseph", "name": { "family": "Razzell Hollis", "given": "Joseph" }, "orcid": "0000-0002-6239-694X" }, { "id": "Cardarelli-Emily-L", "name": { "family": "Cardarelli", "given": "Emily L." }, "orcid": "0000-0001-5451-2309" }, { "name": { "family": "Steele", "given": "Andrew" }, "orcid": "0000-0001-9643-2841" }, { "id": "Beegle-Luther-W", "name": { "family": "Beegle", "given": "Luther W." }, "orcid": "0000-0002-4944-4353" }, { "name": { "family": "Bhartia", 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"Siljestr\u00f6m", "given": "Sandra" }, "orcid": "0000-0002-4975-6074" }, { "name": { "family": "Shkolyar", "given": "Svetlana" }, "orcid": "0000-0001-9641-1071" }, { "name": { "family": "Shuster", "given": "David L." }, "orcid": "0000-0003-2507-9977" }, { "name": { "family": "Simon", "given": "Justin I." }, "orcid": "0000-0002-3969-8958" }, { "name": { "family": "Smith", "given": "Rebecca J." }, "orcid": "0000-0002-1914-1669" }, { "id": "Stack-Kathryn-M", "name": { "family": "Stack", "given": "Kathryn M." }, "orcid": "0000-0003-3444-6695" }, { "id": "Steadman-Kim", "name": { "family": "Steadman", "given": "Kim" }, "orcid": "0000-0002-3192-0489" }, { "name": { "family": "Weiss", "given": "Benjamin P." }, "orcid": "0000-0003-3113-3415" }, { "name": { "family": "Werynski", "given": "Alyssa" }, "orcid": "0000-0002-2264-3133" }, { "name": { "family": "Williams", "given": "Amy J." }, "orcid": "0000-0001-6299-0845" }, { "name": { "family": "Wiens", "given": "Roger C." }, "orcid": "0000-0002-3409-7344" }, { "id": "Williford-Kenneth-H", "name": { "family": "Williford", "given": "Kenneth H." }, "orcid": "0000-0003-0633-408X" }, { "name": { "family": "Winchell", "given": "Kathrine" } }, { "name": { "family": "Wogsland", "given": "Brittan" }, "orcid": "0000-0002-7829-5094" }, { "name": { "family": "Yanchilina", "given": "Anastasia" }, "orcid": "0000-0003-3782-6343" }, { "name": { "family": "Yingling", "given": "Rachel" }, "orcid": "0000-0001-7368-443X" }, { "name": { "family": "Zorzano", "given": "Maria-Paz" }, "orcid": "0000-0002-4492-9650" } ] }, "title": "Aqueous alteration processes in Jezero crater, Mars\u2014implications for organic geochemistry", "ispublished": "pub", "full_text_status": "public", "keywords": "Multidisciplinary", "note": "\u00a9 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. \n\nWe thank the entire Perseverance rover team. The work described in this paper was partially carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration. We thank K. Edgett for his contributions to the team and S. Le Mou\u00e9lic for helpful comments. We thank V. Chevrier and two anonymous reviewers for their improvements to the manuscript. \n\nE.L.S. was supported by a NASA Earth and Space Science Fellowship (NESSF) (grant 80NSSC18K1255). J.R.H. and A.C.F. were supported by a NASA Postdoctoral Program fellowship. E.L.S. J.R.H., A.S., L.W.B., R.B., B.L.E., P.G.C., M.F., F.M.M., and A.S.B. were supported by the NASA Mars 2020 Phase-E funds to the SHERLOC investigation. A.J.W. was supported by the NASA M2020 Participating Scientist Program. T.F. was supported by an Italian Space Agency grant (#2017-48-H.0). A.G.F was supported by the European Research Council Consolidator Grant (#818602). R.W. was funded by NASA contracts NNH15AZ25I and NNH13ZDA018O. S.S. was supported by the Swedish National Space Agency (contracts 137/19 and 2021-00092). K. H.-L. is funded by an Aurora Research Fellowship from the UK Space Agency (grant ST/V00560X/1). \n\nAuthor contributions: E.L.S. and J.R.H. contributed equally to data analysis. E.L.S. and J.R.H. wrote the manuscript with substantial contributions from A.S. and E.C. L.W.B. and R.B. are the principal and deputy investigators of the SHERLOC instrument. K.U. developed the Loupe software. P.C., S.Sha., B.L.E., W.J.A., S.A.A., E.L.B., B.L.B., A.S.B., S.V.B., L.D., D.M.F., T.F., A.C.F., M.F., K.H.-L., W.F.H., J.E.H., S.I., R.S.J., M.R.K., C.L., F.M.M., B.E.N., C.R.S.-V., R.D.R., S.Si., S.Shk., K.S., A.W., K.H.W., K.W., B.W., A.Y., and R.Y. are members of the SHERLOC science and operations teams, who participated in planning and carrying out SHERLOC data acquisitions, calibration, and processing during rover operations. The SHERLOC science team also provided laboratory measurements and data analysis and contributed to the writing of the initial manuscript. T.K., K.R.M., and Y.L. are members of the PIXL team, who assisted in paired SHERLOC and PIXL data analysis. K.C.B., O.B., T.B., A.J.B., E.L.C., A.G.F., K.A.F., L.C.K., P.K., L.M., J.I.N., M.S., M.A.S., S.K.S., D.L.S., J.I.S., R.J.S., K.M.S., B.P.W., A.J.W., R.C.W., and M.P.-Z. are members of the wider Perseverance rover science team; they contributed to planning the SHERLOC data acquisitions, participated in data interpretation, and/or assisted in revising the manuscript. \n\nData and materials availability: The data are available on the Planetary Data System, in the bundles for SHERLOC and WATSON (31), Mastcam-Z (32), Navcam and Hazcam (33), PIXL (34), and Supercam (35); the exact files we used are listed in the supplementary materials. The Loupe software is archived at Zenodo (36). Laboratory data used for the study are archived at Zenodo (37). \n\nWe declare no competing interests.", "abstract": "The Perseverance rover landed in Jezero crater, Mars, in February 2021. We used the Scanning Habitable Environments with Raman and Luminescence for Organics and Chemicals (SHERLOC) instrument to perform deep-ultraviolet Raman and fluorescence spectroscopy of three rocks within the crater. We identify evidence for two distinct ancient aqueous environments at different times. Reactions with liquid water formed carbonates in an olivine-rich igneous rock. A sulfate-perchlorate mixture is present in the rocks, which probably formed by later modifications of the rocks by brine. Fluorescence signatures consistent with aromatic organic compounds occur throughout these rocks and are preserved in minerals related to both aqueous environments.", "date": "2022-12-09", "date_type": "published", "publication": "Science", "volume": "378", "number": "6624", "publisher": "American Association for the Advancement of Science", "pagerange": "1105-1110", "id_number": "CaltechAUTHORS:20221212-615183000.3", "issn": "0036-8075", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20221212-615183000.3", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NASA Earth and Space Science Fellowship", "grant_number": "80NSSC18K1255" }, { "agency": "NASA Postdoctoral Program" }, { "agency": "Agenzia Spaziale Italiana (ASI)", "grant_number": "2017-48-H.0" }, { "agency": "European Research Council (ERC)", "grant_number": "818602" }, { "agency": "NASA", "grant_number": "NNH15AZ25I" }, { "agency": "NASA", "grant_number": "NNH13ZDA018O" }, { "agency": "Swedish National Space Agency", "grant_number": "137/19" }, { "agency": "Swedish National Space Agency", "grant_number": "2021-00092" }, { "agency": "United Kingdom Space Agency (UKSA)", "grant_number": "ST/V00560X/1" } ] }, "local_group": { "items": [ { "id": "Division-of-Geological-and-Planetary-Sciences" } ] }, "doi": "10.1126/science.abo5204", "resource_type": "article", "pub_year": "2022", "author_list": "Scheller, Eva L.; Razzell Hollis, Joseph; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/58ryp-60r92", "eprint_id": 121358, "eprint_status": "archive", "datestamp": "2023-08-22 18:16:10", "lastmod": "2023-10-20 15:26:06", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Tice-Michael-M", "name": { "family": "Tice", "given": "Michael M." }, "orcid": "0000-0003-2560-1702" }, { "id": "Hurowitz-Joel-A", "name": { "family": "Hurowitz", "given": "Joel A." }, "orcid": "0000-0002-5857-8652" }, { "id": "Allwood-Abigail-C", "name": { "family": "Allwood", "given": "Abigail C." }, "orcid": "0009-0002-9779-7855" }, { "id": "Jones-Michael-W-M", "name": { "family": "Jones", "given": "Michael W. M." }, "orcid": "0000-0002-0720-8715" }, { "id": "Orenstein-Brendan-J", "name": { "family": "Orenstein", "given": "Brendan J." }, "orcid": "0000-0002-6586-4227" }, { "id": "Davidoff-Scott", "name": { "family": "Davidoff", "given": "Scott" }, "orcid": "0000-0002-4417-7268" }, { "id": "Wright-Austin-P", "name": { "family": "Wright", "given": "Austin P." }, "orcid": "0000-0002-0197-4638" }, { "id": "Pedersen-David-A-K", "name": { "family": "Pedersen", "given": "David A. K." }, "orcid": "0000-0001-7182-8567" }, { "id": "Henneke-Jesper", "name": { "family": "Henneke", "given": "Jesper" }, "orcid": "0000-0002-3195-7417" }, { "id": "Tosca-Nicholas-J", "name": { "family": "Tosca", "given": "Nicholas J." }, "orcid": "0000-0003-4415-4231" }, { "id": "Moore-Kelsey-R", "name": { "family": "Moore", "given": "Kelsey R." }, "orcid": "0000-0002-4905-9623" }, { "id": "Clark-Benton-C", "name": { "family": "Clark", "given": "Benton C." }, "orcid": "0000-0002-5546-8757" }, { "id": "McLennan-Scott-M", "name": { "family": "McLennan", "given": "Scott M." }, "orcid": "0000-0003-4259-7178" }, { "id": "Flannery-David-T", "name": { "family": "Flannery", "given": "David T." }, "orcid": "0000-0001-8982-496X" }, { "id": "Steele-Andrew", "name": { "family": "Steele", "given": "Andrew" }, "orcid": "0000-0001-9643-2841" }, { "id": "Brown-Adrian-Jon", "name": { "family": "Brown", "given": "Adrian J." }, "orcid": "0000-0002-9352-6989" }, { "id": "Zorzano-Maria-Paz", "name": { "family": "Zorzano", "given": "Maria-Paz" }, "orcid": "0000-0002-4492-9650" }, { "id": "Hickman-Lewis-Keyron", "name": { "family": "Hickman-Lewis", "given": "Keyron" }, "orcid": "0000-0001-8014-233X" }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0003-0308-0942" }, { "id": "VanBommel-Scott-J", "name": { "family": "VanBommel", "given": "Scott J." }, "orcid": "0000-0002-6565-0827" }, { "id": "Schmidt-Mariek-E", "name": { "family": "Schmidt", "given": "Mariek E." }, "orcid": "0000-0003-4793-7899" }, { "id": "Kizovski-Tanya-V", "name": { "family": "Kizovski", "given": "Tanya V." }, "orcid": "0000-0001-8188-9769" }, { "id": "Treiman-Allan-H", "name": { "family": "Treiman", "given": "Allan H." }, "orcid": "0000-0002-8073-2839" }, { "id": "O'Neil-Lauren", "name": { "family": "O'Neil", "given": "Lauren" }, "orcid": "0000-0003-1555-8229" }, { "id": "Fair\u00e9n-Alberto-G", "name": { "family": "Fair\u00e9n", "given": "Alberto G." }, "orcid": "0000-0002-2938-6010" }, { "id": "Shuster-David-L", "name": { "family": "Shuster", "given": "David L." }, "orcid": "0000-0003-2507-9977" }, { "id": "Gupta-Sanjeev", "name": { "family": "Gupta", "given": "Sanjeev" }, "orcid": "0000-0001-6415-1332" } ] }, "title": "Alteration history of S\u00e9\u00edtah formation rocks inferred by PIXL x-ray fluorescence, x-ray diffraction, and multispectral imaging on Mars", "ispublished": "pub", "full_text_status": "public", "keywords": "Multidisciplinary", "note": "\u00a9 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). \n\nWe are grateful to Mars 2020 team members who participated in tactical and strategic science operations. We acknowledge T. Wang (Central Analytical Research Facility, Queensland University of Technology) for assistance with theoretically modeling EDXRD. \n\nThe work described in this paper was partially carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a prime contract with the National Aeronautics and Space Administration (80NM0018D0004). M.M.T., J.A.H., A.C.A., S.D., A.P.W., K.R.M., B.C.C., S.M.M., A.S., A.J.B., Y.L., A.H.T., and L.O. were supported by NASA grant 80NM0018D0004 through J.P.L. S.J.V. and D.L.S. were supported by the NASA M2020 Participating Scientist Programs. M.E.S. and T.V.K. were supported by the Canadian Space Agency M2020 Participating Scientist grants. K.H.-L. was supported by a UK Space Agency Aurora Research Fellowship. A.G.F. was supported by the European Research Council CoG no. 818602. S.G. was supported by the U.K. Space Agency and Royal Society (SRF\\R1\\21000106). D.T.F. was supported by Australian Research Council grant DE210100205. D.A.K.P. and J.H. were supported by the National Space Institute, Technical University of Denmark. N.J.T. was supported by the Cambridge University. S.G. was supported by the Royal Society Leverhulme Trust Senior Research Fellowship (SRF\\R1\\21000106) and the U.K. Space Agency (grant numbers: ST/X002373/1 and ST/S001492/1). \n\nAuthor contributions: M.M.T. led the writing of the manuscript. M.M.T., J.A.H., A.C.A., M.W.M.J., B.J.O., S.D., A.P.W., D.A.K.P., J.H., N.J.T., K.R.M., B.C.C., S.M.M., D.T.F., A.S., A.J.B., M.P.Z., K.H.L., Y.L., and S.J.V. prepared the original draft with input from A.G.F., D.L.S., and S.G. All authors provided input to the manuscript through discussion, editing, or reviewing. M.M.T., J.A.H., A.C.A., M.W.M.J., B.J.O., D.A.K.P., J.H., N.J.T., K.R.M., B.C.C., D.T.F., Y.L., S.J.V., M.E.S., T.V.K., A.H.T., and L.O. contributed to the design, execution, and analysis of PIXL observations. All authors contributed to the selection and geologic interpretation of the rocks discussed here. M.M.T., M.W.M.J., B.J.O., S.D., A.P.W., D.A.K.P., J.H., and B.C.C. performed data processing and analysis. M.M.T., M.W.M.J., B.J.O., S.D., A.P.W., D.A.K.P., J.H., and B.C.C. prepared visualizations. Project management of the PIXL investigation was by A.C.A. and J.A.H. \n\nData and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials. PIXL images and data used in this paper are available on the Planetary Data System (PDS; doi:10.17189/1522645; https://pds.nasa.gov/ds-view/pds/viewBundle.jsp?identifier=urn%3Anasa%3Apds%3Amars2020_pixl&version=1.0). \n\nThe authors declare that they have no competing interests.\n\nPublished - sciadv.abp9084.pdf
Supplemental Material - sciadv.abp9084_sm.pdf
", "abstract": "Collocated crystal sizes and mineral identities are critical for interpreting textural relationships in rocks and testing geological hypotheses, but it has been previously impossible to unambiguously constrain these properties using in situ instruments on Mars rovers. Here, we demonstrate that diffracted and fluoresced x-rays detected by the PIXL instrument (an x-ray fluorescence microscope on the Perseverance rover) provide information about the presence or absence of coherent crystalline domains in various minerals. X-ray analysis and multispectral imaging of rocks from the S\u00e9\u00edtah formation on the floor of Jezero crater shows that they were emplaced as coarsely crystalline igneous phases. Olivine grains were then partially dissolved and filled by finely crystalline or amorphous secondary silicate, carbonate, sulfate, and chloride/oxychlorine minerals. These results support the hypothesis that S\u00e9\u00edtah formation rocks represent olivine cumulates altered by fluids far from chemical equilibrium at low water-rock ratios.", "date": "2022-11-25", "date_type": "published", "publication": "Science Advances", "volume": "8", "number": "47", "publisher": "American Association for the Advancement of Science", "pagerange": "Art. No. eabp9084", "id_number": "CaltechAUTHORS:20230509-289950400.1", "issn": "2375-2548", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20230509-289950400.1", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NASA/JPL/Caltech", "grant_number": "80NM0018D0004" }, { "agency": "Canadian Space Agency (CSA)" }, { "agency": "United Kingdom Space Agency (UKSA)", "grant_number": "ST/X002373/1" }, { "agency": "European Research Council (ERC)", "grant_number": "818602" }, { "agency": "Royal Society", "grant_number": "SRF\\R1\\21000106" }, { "agency": "Australian Research Council", "grant_number": "DE210100205" }, { "agency": "Technical University of Denmark" }, { "agency": "Cambridge University" }, { "agency": "Leverhulme Trust" }, { "agency": "United Kingdom Space Agency (UKSA)", "grant_number": "ST/S001492/1" } ] }, "corp_creators": { "items": [ "PIXL Team" ] }, "doi": "10.1126/sciadv.abp9084", "pmcid": "PMC9683721", "primary_object": { "basename": "sciadv.abp9084_sm.pdf", "url": "https://authors.library.caltech.edu/records/58ryp-60r92/files/sciadv.abp9084_sm.pdf" }, "related_objects": [ { "basename": "sciadv.abp9084.pdf", "url": "https://authors.library.caltech.edu/records/58ryp-60r92/files/sciadv.abp9084.pdf" } ], "resource_type": "article", "pub_year": "2022", "author_list": "Tice, Michael M.; Hurowitz, Joel A.; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/3jm6q-vz564", "eprint_id": 118387, "eprint_status": "archive", "datestamp": "2023-08-22 17:46:06", "lastmod": "2023-10-24 23:20:12", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Y." }, "orcid": "0000-0003-0308-0942" }, { "name": { "family": "Tice", "given": "M. 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M." }, "orcid": "0000-0002-8313-8595" }, { "name": { "family": "Sautter", "given": "V." }, "orcid": "0000-0002-4263-7558" }, { "name": { "family": "Shuster", "given": "D. L." }, "orcid": "0000-0003-2507-9977" }, { "name": { "family": "Siebach", "given": "K. L." }, "orcid": "0000-0002-6628-6297" }, { "name": { "family": "Simon", "given": "J. I." }, "orcid": "0000-0002-3969-8958" }, { "name": { "family": "Sinclair", "given": "K. P." }, "orcid": "0000-0001-6261-4591" }, { "id": "Stack-Kathryn-M", "name": { "family": "Stack", "given": "K. M." }, "orcid": "0000-0003-3444-6695" }, { "name": { "family": "Steele", "given": "A." }, "orcid": "0000-0001-9643-2841" }, { "id": "Tarnas-Jesse-D", "name": { "family": "Tarnas", "given": "J. D." }, "orcid": "0000-0002-6256-0826" }, { "name": { "family": "Tosca", "given": "N. J." }, "orcid": "0000-0003-4415-4231" }, { "id": "Uckert-Kyle", "name": { "family": "Uckert", "given": "K." }, "orcid": "0000-0002-0859-5526" }, { "name": { "family": "Udry", "given": "A." }, "orcid": "0000-0002-0074-8110" }, { "id": "Wade-Lawrence-A", "name": { "family": "Wade", "given": "L. A." }, "orcid": "0000-0001-8254-8181" }, { "name": { "family": "Weiss", "given": "B. P." }, "orcid": "0000-0003-3113-3415" }, { "name": { "family": "Wiens", "given": "R. C." }, "orcid": "0000-0002-3409-7344" }, { "id": "Williford-Kenneth-H", "name": { "family": "Williford", "given": "K. H." }, "orcid": "0000-0003-0633-408X" }, { "name": { "family": "Zorzano", "given": "M.-P." }, "orcid": "0000-0002-4492-9650" } ] }, "title": "An olivine cumulate outcrop on the floor of Jezero crater, Mars", "ispublished": "pub", "full_text_status": "public", "keywords": "Multidisciplinary", "note": "We are grateful to the Mars 2020 team members who participated in tactical and strategic science operations. Detailed comments by K. Edgett are greatly appreciated. Y.L. thanks L. P. Keszthelyi for the discussion about Earth and Mars lava flows; N. Williams for providing the base maps used in Fig. 1, A and C; and J. Bell for providing the image used in Fig. 1D.\n\nThe work described in this paper was partially carried out at the Jet Propulsion Laboratory (JPL), California Institute of Technology, under a prime contract with the National Aeronautics and Space Administration (80NM0018D0004). Y.L., M.M.T., A.C.A., J.A.H., C.M.H., S.D., R.P.H., J.H., D.A.K.P., J.L.J., K.A.F., K.M.S., J.D.T., B.C.C., E.L.C., K.M., L.W.B., L.A.W., J.P.G., A.H.T., B.H.N.H., J.R.J., W.T.E., S.M.M., A.G., R.C.W., and K.U. were supported by NASA grant 80NM0018D0004 through JPL. J.R.J. was also supported by ASU subcontract 15-707. R.C.W. was also supported by NASA grant NNH13ZDA018O for Supercam to LANL. D.T.F. was supported by Australian Research Council grant DE210100205. E.A.C. was supported by Canadian Space Agency grant 19PACOI0 and Natural Sciences and Engineering Research Council of Canada grant RGPIN-2021-02995. C.D.K.H., T.V.K., and M.E.S. were supported by Canadian Space Agency M2020 Participating Scientist grants. A.U., S.J.V., B.A.C., M.N., D.L.S., J.I.S., K.L.S., T.Bo., and B.P.W. were supported by NASA Mars 2020 Participating Scientist grants. The work of K.B., S.B., O.B., L.M., N.M., C.M.Q.-N., and V.S. on Mars 2020 was supported by CNES. K.H.-L. was supported by a UK Space Agency Aurora Research Fellowship. T.Bo. was supported by the Simons Foundation Collaboration on the Origins of Life. S.G. was supported by the UK Space Agency and the Royal Society (grant SRF\\R1\\21000106). A.G.F. was supported by the European Research Council CoG #818602.", "abstract": "The geological units on the floor of Jezero crater, Mars, are part of a wider regional stratigraphy of olivine-rich rocks, which extends well beyond the crater. We investigated the petrology of olivine and carbonate-bearing rocks of the S\u00e9\u00edtah formation in the floor of Jezero. Using multispectral images and x-ray fluorescence data, acquired by the Perseverance rover, we performed a petrographic analysis of the Bastide and Brac outcrops within this unit. We found that these outcrops are composed of igneous rock, moderately altered by aqueous fluid. The igneous rocks are mainly made of coarse-grained olivine, similar to some martian meteorites. We interpret them as an olivine cumulate, formed by settling and enrichment of olivine through multistage cooling of a thick magma body.", "date": "2022-09-30", "date_type": "published", "publication": "Science", "volume": "377", "number": "6614", "publisher": "American Association for the Advancement of Science", "pagerange": "1513-1519", "id_number": "CaltechAUTHORS:20221215-431170800.7", "issn": "0036-8075", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20221215-431170800.7", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NASA/JPL/Caltech", "grant_number": "80NM0018D0004" }, { "agency": "JPL", "grant_number": "15-707" }, { "agency": "NASA", "grant_number": "NNH13ZDA018O" }, { "agency": "Australian Research Council", "grant_number": "DE210100205" }, { "agency": "Canadian Space Agency (CSA)", "grant_number": "19PACOI0" }, { "agency": "Natural Sciences and Engineering Research Council of Canada (NSERC)", "grant_number": "RGPIN-2021-02995" }, { "agency": "Canadian Space Agency (CSA)" }, { "agency": "Centre National d'\u00c9tudes Spatiales (CNES)" }, { "agency": "United Kingdom Space Agency (UKSA)" }, { "agency": "Simons Foundation" }, { "agency": "Royal Society", "grant_number": "SRF\\R1\\21000106" }, { "agency": "European Research Council (ERC)", "grant_number": "818602" } ] }, "local_group": { "items": [ { "id": "Division-of-Geological-and-Planetary-Sciences" } ] }, "doi": "10.1126/science.abo2756", "resource_type": "article", "pub_year": "2022", "author_list": "Liu, Y.; Tice, M. M.; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/42j82-1hz60", "eprint_id": 118293, "eprint_status": "archive", "datestamp": "2023-08-22 17:45:58", "lastmod": "2023-10-24 23:16:25", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Farley-K-A", "name": { "family": "Farley", "given": "K. A." }, "orcid": "0000-0002-7846-7546" }, { "id": "Stack-Kathryn-M", "name": { "family": "Stack", "given": "K. M." }, "orcid": "0000-0003-3444-6695" }, { "name": { "family": "Shuster", "given": "D. L." }, "orcid": "0000-0003-2507-9977" }, { "name": { "family": "Horgan", "given": "B. H. N." }, "orcid": "0000-0001-6314-9724" }, { "name": { "family": "Hurowitz", "given": "J. A." }, "orcid": "0000-0002-5857-8652" }, { "id": "Tarnas-Jesse-D", "name": { "family": "Tarnas", "given": "J. D." }, "orcid": "0000-0002-6256-0826" }, { "name": { "family": "Simon", "given": "J. 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S." } }, { "id": "Sharma-Sunanda", "name": { "family": "Sharma", "given": "S." }, "orcid": "0000-0001-8822-7960" }, { "name": { "family": "Siljestr\u00f6m", "given": "S." }, "orcid": "0000-0002-4975-6074" }, { "name": { "family": "Steele", "given": "A." }, "orcid": "0000-0001-9643-2841" }, { "name": { "family": "Sullivan", "given": "R." }, "orcid": "0000-0003-4191-598X" }, { "name": { "family": "Wadhwa", "given": "M." }, "orcid": "0000-0001-9187-1255" }, { "id": "Weiss-Benjamin-P", "name": { "family": "Weiss", "given": "B. P." }, "orcid": "0000-0003-3113-3415" }, { "name": { "family": "Williams", "given": "A. J." }, "orcid": "0000-0001-6299-0845" }, { "name": { "family": "Wogsland", "given": "B. V." }, "orcid": "0000-0002-7829-5094" }, { "id": "Willis-Peter-A", "name": { "family": "Willis", "given": "P. A." }, "orcid": "0000-0001-5394-1101" }, { "name": { "family": "Acosta-Maeda", "given": "T. A." } }, { "name": { "family": "Beck", "given": "P." }, "orcid": "0000-0002-6532-5602" }, { "name": { "family": "Benzerara", "given": "K." }, "orcid": "0000-0002-0553-0137" }, { "name": { "family": "Bernard", "given": "S." }, "orcid": "0000-0001-5576-7020" }, { "name": { "family": "Burton", "given": "A. S." }, "orcid": "0000-0002-1194-4336" }, { "id": "Cardarelli-Emily-L", "name": { "family": "Cardarelli", "given": "E. L." }, "orcid": "0000-0001-5451-2309" }, { "name": { "family": "Chide", "given": "B." }, "orcid": "0000-0002-5124-9119" }, { "name": { "family": "Clav\u00e9", "given": "E." }, "orcid": "0000-0002-9514-8168" }, { "name": { "family": "Cloutis", "given": "E. A." }, "orcid": "0000-0001-7301-0929" }, { "name": { "family": "Cohen", "given": "B. A." }, "orcid": "0000-0001-5896-5903" }, { "name": { "family": "Czaja", "given": "A. D." }, "orcid": "0000-0002-2450-0734" }, { "name": { "family": "Debaille", "given": "V." }, "orcid": "0000-0002-6544-4564" }, { "name": { "family": "Dehouck", "given": "E." }, "orcid": "0000-0002-1368-4494" }, { "name": { "family": "Fair\u00e9n", "given": "A. G." }, "orcid": "0000-0002-2938-6010" }, { "name": { "family": "Flannery", "given": "D. T." }, "orcid": "0000-0001-8982-496X" }, { "name": { "family": "Fleron", "given": "S. Z." }, "orcid": "0000-0001-7413-3912" }, { "name": { "family": "Fouchet", "given": "T." }, "orcid": "0000-0001-9040-8285" }, { "name": { "family": "Frydenvang", "given": "J." }, "orcid": "0000-0001-9294-1227" }, { "name": { "family": "Garczynski", "given": "B. J." }, "orcid": "0000-0002-7668-3675" }, { "name": { "family": "Gibbons", "given": "E. F." }, "orcid": "0000-0002-4789-4772" }, { "name": { "family": "Hausrath", "given": "E. M." }, "orcid": "0000-0002-5520-1622" }, { "name": { "family": "Hayes", "given": "A. G." }, "orcid": "0000-0001-6397-2630" }, { "name": { "family": "Henneke", "given": "J." }, "orcid": "0000-0002-3195-7417" }, { "name": { "family": "J\u00f8rgensen", "given": "J. L." }, "orcid": "0000-0002-0343-239X" }, { "name": { "family": "Kelly", "given": "E. M." }, "orcid": "0000-0002-2233-3901" }, { "name": { "family": "Lasue", "given": "J." }, "orcid": "0000-0001-9082-4457" }, { "name": { "family": "Le Mou\u00e9lic", "given": "S." }, "orcid": "0000-0001-5260-1367" }, { "name": { "family": "Madariaga", "given": "J. M." }, "orcid": "0000-0002-1685-6335" }, { "name": { "family": "Maurice", "given": "S." }, "orcid": "0000-0001-5702-8002" }, { "name": { "family": "Merusi", "given": "M." }, "orcid": "0000-0003-0570-9177" }, { "name": { "family": "Meslin", "given": "P.-Y." }, "orcid": "0000-0002-0703-3951" }, { "id": "Milkovich-Sarah-M", "name": { "family": "Milkovich", "given": "S. M." } }, { "name": { "family": "Million", "given": "C. C." }, "orcid": "0000-0003-2732-3486" }, { "id": "Moeller-Robert-C", "name": { "family": "Moeller", "given": "R. C." } }, { "name": { "family": "N\u00fa\u00f1ez", "given": "J. I." }, "orcid": "0000-0003-0930-6674" }, { "name": { "family": "Ollila", "given": "A. M." }, "orcid": "0000-0003-0479-9465" }, { "name": { "family": "Paar", "given": "G." }, "orcid": "0000-0003-3198-8640" }, { "name": { "family": "Paige", "given": "D. A." } }, { "name": { "family": "Pedersen", "given": "D. A. K." }, "orcid": "0000-0001-7182-8567" }, { "name": { "family": "Pilleri", "given": "P." }, "orcid": "0000-0003-4861-0476" }, { "name": { "family": "Pilorget", "given": "C." }, "orcid": "0000-0002-7759-9854" }, { "name": { "family": "Pinet", "given": "P. C." }, "orcid": "0000-0002-1933-5631" }, { "name": { "family": "Rice", "given": "J. W." } }, { "name": { "family": "Royer", "given": "C." }, "orcid": "0000-0002-5472-7235" }, { "name": { "family": "Sautter", "given": "V." }, "orcid": "0000-0002-4263-7558" }, { "name": { "family": "Schulte", "given": "M." }, "orcid": "0000-0001-8141-2020" }, { "name": { "family": "Sephton", "given": "M. A." }, "orcid": "0000-0002-2190-5402" }, { "name": { "family": "Sharma", "given": "S. K." }, "orcid": "0000-0002-5676-7572" }, { "id": "Sholes-Steven-F", "name": { "family": "Sholes", "given": "S. F." }, "orcid": "0000-0003-4854-1191" }, { "id": "Spanovich-Nicole", "name": { "family": "Spanovich", "given": "N." }, "orcid": "0000-0002-9584-5043" }, { "name": { "family": "St. Clair", "given": "M." }, "orcid": "0000-0002-7877-3148" }, { "name": { "family": "Tate", "given": "C. D." }, "orcid": "0000-0003-3467-0099" }, { "id": "Uckert-Kyle", "name": { "family": "Uckert", "given": "K." }, "orcid": "0000-0002-0859-5526" }, { "name": { "family": "VanBommel", "given": "S. J." }, "orcid": "0000-0002-6565-0827" }, { "name": { "family": "Yanchilina", "given": "A. G." }, "orcid": "0000-0003-3782-6343" }, { "name": { "family": "Zorzano", "given": "M.-P." }, "orcid": "0000-0002-4492-9650" } ] }, "title": "Aqueously altered igneous rocks sampled on the floor of Jezero crater, Mars", "ispublished": "pub", "full_text_status": "public", "keywords": "Multidisciplinary", "note": "Funding: This effort was carried out in part at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration (80NM0018D0004). K.A.F., K.M.S., J.D.T., V.Z.S., Y.L., J.N.M., A.C.A., Y.G., P.A.W., E.L.C., S.M.Mi., R.C.M., S.F.S., N.S., and K.U. were supported by NASA grant 80NM0018D0004 through JPL. D.T.F. was supported by Australian Research Council grant DE210100205. E.F.G. was supported by Canadian Space Agency grant 21EXPCOI1. E.A.C. was supported by Canadian Space Agency grant 19PACOI0 and Natural Sciences and Engineering Research Council of Canada grant RGPIN-2021-02995. C.D.K.H., T.V.K., and M.E.S. were supported by Canadian Space Agency M2020 Participating Scientist grants. M.M. was supported by the EU's Horizon 2020 research and innovation program under the Marie Sk\u0142odowska Curie grant 801199. G.P. was supported by ESA PRODEX Experiment Arrangement PEA 4000117520. V.D. was supported by Fonds pour la Recherche Scientifique. A.J.W., S.J.V., D.L.S., J.I.S., L.E.M., T.B., and E.M.H. were supported by NASA Mars 2020 Participating Scientist grants. T.B. was supported by the Simons Foundation Collaboration on the Origins of Life grant 327126. R.C.W. was supported by NASA Mars 2020 contracts NNH15AZ24I and NNH13ZDA018O for SuperCam and a LANL internal LDRD grant. S.K.S. was supported by JPL subcontract 1654163. S.G. was supported by the Royal Society Leverhulme Trust Senior Research Fellowship (SRF\\R1\\21000106) and the UK Space Agency Aurora program. M.-P.Z. was supported by the Spanish Ministry of Science and Innovation under grant PID2019-104205GB-C21. S.Si. was supported by the Swedish National Space Agency under contracts 137/19 and 2021-00092. K.B.K. was supported by the Carlsberg Foundation, grant CF19-0023. S.-E.H. was supported by the Research Council of Norway under grants 301238 and 309835. The work of O.B., A.C., O.F., L.M., N.M., C.Q.-N., P.B., K.B., B.C., E.C., E.D., T.F., J.L., S.L.M., S.M., P.-Y.M., P.P., C.P., P.C.P., C.R., and V.S. on Mars 2020 was supported by CNES. K.H.-L. was supported by a UK Space Agency Aurora Research Fellowship. M.A.S. was supported by UK Space Agency grants ST/V002732/1 and ST/V006134/1. J.F.B. was supported by NASA-JPL subcontract number 1511125. A.G.F. was supported by the European Research Council, Consolidator Grant 818602.", "abstract": "The Perseverance rover landed in Jezero crater, Mars, to investigate ancient lake and river deposits. We report observations of the crater floor, below the crater's sedimentary delta, finding that the floor consists of igneous rocks altered by water. The lowest exposed unit, informally named S\u00e9\u00edtah, is a coarsely crystalline olivine-rich rock, which accumulated at the base of a magma body. Magnesium-iron carbonates along grain boundaries indicate reactions with carbon dioxide\u2013rich water under water-poor conditions. Overlying S\u00e9\u00edtah is a unit informally named M\u00e1az, which we interpret as lava flows or the chemical complement to S\u00e9\u00edtah in a layered igneous body. Voids in these rocks contain sulfates and perchlorates, likely introduced by later near-surface brine evaporation. Core samples of these rocks have been stored aboard Perseverance for potential return to Earth.", "date": "2022-09-30", "date_type": "published", "publication": "Science", "volume": "377", "number": "6614", "publisher": "American Association for the Advancement of Science", "pagerange": "Art. No. eabo2196", "id_number": "CaltechAUTHORS:20221212-615014000.1", "issn": "0036-8075", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20221212-615014000.1", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NASA/JPL/Caltech", "grant_number": "80NM0018D0004" }, { "agency": "Australian Research Council", "grant_number": "DE210100205" }, { "agency": "Canadian Space Agency (CSA)", "grant_number": "21EXPCOI1" }, { "agency": "Canadian Space Agency (CSA)", "grant_number": "19PACOI0" }, { "agency": "Natural Sciences and Engineering Research Council of Canada (NSERC)", "grant_number": "RGPIN-2021-02995" }, { "agency": "Marie Curie Fellowship", "grant_number": "801199" }, { "agency": "European Space Agency (ESA)", "grant_number": "PEA 4000117520" }, { "agency": "Fonds de la Recherche Scientifique (FNRS)" }, { "agency": "Simons Foundation", "grant_number": "327126" }, { "agency": "NASA", "grant_number": "NNH15AZ24I" }, { "agency": "NASA", "grant_number": "NNH13ZDA018O" }, { "agency": "Los Alamos National Laboratory" }, { "agency": "JPL", "grant_number": "1654163" }, { "agency": "Royal Society", "grant_number": "SRF\\R1\\21000106" }, { "agency": "Ministerio de Ciencia e Innovaci\u00f3n (MCINN)", "grant_number": "PID2019-104205GB-C21" }, { "agency": "Swedish National Space Agency", "grant_number": "137/19" }, { "agency": "Swedish National Space Agency", "grant_number": "2021-00092" }, { "agency": "Carlsberg Foundation", "grant_number": "CF19-0023" }, { "agency": "Research Council of Norway", "grant_number": "301238" }, { "agency": "Research Council of Norway", "grant_number": "309835" }, { "agency": "Centre National d'\u00c9tudes Spatiales (CNES)" }, { "agency": "United Kingdom Space Agency (UKSA)", "grant_number": "ST/V002732/1" }, { "agency": "United Kingdom Space Agency (UKSA)", "grant_number": "ST/V006134/1" }, { "agency": "JPL", "grant_number": "1511125" }, { "agency": "European Research Council (ERC)", "grant_number": "818602" } ] }, "local_group": { "items": [ { "id": "Division-of-Geological-and-Planetary-Sciences" } ] }, "doi": "10.1126/science.abo2196", "resource_type": "article", "pub_year": "2022", "author_list": "Farley, K. A.; Stack, K. M.; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/5rf5x-8tj69", "eprint_id": 115169, "eprint_status": "archive", "datestamp": "2023-08-22 16:02:07", "lastmod": "2023-10-24 15:26:08", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Huang-Jin", "name": { "family": "Huang", "given": "Jin" } }, { "id": "Sementa-Luca", "name": { "family": "Sementa", "given": "Luca" } }, { "id": "Liu-Zeyan", "name": { "family": "Liu", "given": "Zeyan" }, "orcid": "0000-0001-9237-7603" }, { "id": "Barcaro-Giovanni", "name": { "family": "Barcaro", "given": "Giovanni" }, "orcid": "0000-0002-5520-5914" }, { "id": "Feng-Miao", "name": { "family": "Feng", "given": "Miao" } }, { "id": "Liu-Ershuai", "name": { "family": "Liu", "given": "Ershuai" } }, { "id": "Jiao-Li", "name": { "family": "Jiao", "given": "Li" }, "orcid": "0000-0002-1063-9313" }, { "id": "Xu-Mingjie", "name": { "family": "Xu", "given": "Mingjie" } }, { "id": "Leshchev-Denis", "name": { "family": "Leshchev", "given": "Denis" } }, { "id": "Lee-Sung-Joon", "name": { "family": "Lee", "given": "Sung-Joon" }, "orcid": "0000-0003-2368-4647" }, { "id": "Li-Mufan", "name": { "family": "Li", "given": "Mufan" }, "orcid": "0000-0002-4575-4055" }, { "id": "Wan-Chengzhang", "name": { "family": "Wan", "given": "Chengzhang" } }, { "id": "Zhu-Enbo", "name": { "family": "Zhu", "given": "Enbo" } }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" } }, { "id": "Peng-Bosi", "name": { "family": "Peng", "given": "Bosi" } }, { "id": "Duan-Xiangfeng", "name": { "family": "Duan", "given": "Xiangfeng" }, "orcid": "0000-0002-4321-6288" }, { "id": "Goddard-W-A-III", "name": { "family": "Goddard", "given": "William A., III" }, "orcid": "0000-0003-0097-5716" }, { "id": "Fortunelli-Alessandro", "name": { "family": "Fortunelli", "given": "Alessandro" }, "orcid": "0000-0001-5337-4450" }, { "id": "Jia-Qingying", "name": { "family": "Jia", "given": "Qingying" }, "orcid": "0000-0002-4005-8894" }, { "id": "Huang-Yu", "name": { "family": "Huang", "given": "Yu" }, "orcid": "0000-0003-1793-0741" } ] }, "title": "Experimental Sabatier plot for predictive design of active and stable Pt-alloy oxygen reduction reaction catalysts", "ispublished": "pub", "full_text_status": "public", "keywords": "Process Chemistry and Technology; Biochemistry; Bioengineering; Catalysis", "note": "\u00a9 The Author(s), under exclusive licence to Springer Nature Limited 2022. \n\nReceived 12 July 2021; Accepted 26 April 2022; Published 09 June 2022. \n\nY.H., Q.J., W.A.G. and X.D. gratefully acknowledge the support of the Office of Naval Research (award N000141812155). The XAS data were collected at beamlines 6-BM, 7-BM and 8-ID of the National Synchrotron Light Source II, a US Department of Energy Office of Science User Facility operated for the Department of Energy Office of Science by Brookhaven National Laboratory under contract no. DE-SC0012704. We acknowledge the use of facilities and instrumentation at the University of California Irvine Materials Research Institute, supported in part by the National Science Foundation Materials Research Science and Engineering Center programme through the University of California Irvine Center for Complex and Active Materials (DMR-2011967). We also thank the Electron Imaging Center of Nanomachines at the California NanoSystems Institute (CNSI) for TEM support. A.F. and W.A.G. received support from the National Science Foundation (CBET-1805022 and CBET-2005250). A.F., G.B. and L.S. gratefully acknowledge the contribution of the International Research Network on Nanoalloys Centre national de la recherche scientifique (CNRS) and computational support from the CINECA supercomputing centre within the Italian SuperComputing Resource Allocation (ISCRA) programme. \n\nData availability: The atomic coordinates of the DFT calculation data and simulated XANES data are available in the Supplementary Data. The data that support the findings of this study are available from the corresponding authors upon reasonable request. Source data are provided with this paper. \n\nContributions: J.H., M.F., M.L., Y.L., C.W., S.-J.L., B.P. and Z.L. conducted the synthesis of electrocatalysts, structural characterization and electrochemical experiments. M.X. and J.H. conducted the TEM and EDX characterizations. Q.J., E.L., L.J. and D.L. conducted the XAS studies. A.F., L.S., G.B., Q.J., J.H. and W.A.G. performed the modelling and data analyses. The project was conceived by Y.H. and supervised by Y.H. (project design, syntheses and evaluation of the catalysts); Q.J. (XAS studies); and A.F. and W.A.G. (computational studies). J.H., Y.H., Q.J. and A.F. wrote the original draught. J.H., Y.H., Q.J., A.F., W.A.G. and Z.L. revised the manuscript. \n\nThe authors declare no competing interests. \n\nPeer review information: Nature Catalysis thanks Janis Timoshenko and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.\n\nSupplemental Material - 41929_2022_797_MOESM1_ESM.pdf
Supplemental Material - 41929_2022_797_MOESM2_ESM.txt
Supplemental Material - 41929_2022_797_MOESM3_ESM.txt
", "abstract": "A critical technological roadblock to the widespread adoption of proton-exchange membrane fuel cells is the development of highly active and durable platinum-based catalysts for accelerating the sluggish oxygen reduction reaction, which has largely relied on anecdotal discoveries so far. While the oxygen binding energy \u2206E\u2080 has been frequently used as a theoretical descriptor for predicting the activity, there is no known descriptor for predicting durability. Here we developed a binary experimental descriptor that captures both the strain and Pt transition metal coupling contributions through X-ray absorption spectroscopy and directly correlated the binary experimental descriptor with the calculated \u2206EO of the catalyst surface. This leads to an experimentally validated Sabatier plot to predict both the catalytic activity and stability for a wide range of Pt-alloy oxygen reduction reaction catalysts. Based on the binary experimental descriptor, we further designed an oxygen reduction reaction catalyst wherein high activity and stability are simultaneously achieved.", "date": "2022-06", "date_type": "published", "publication": "Nature Catalysis", "volume": "5", "number": "6", "publisher": "Nature Publishing Group", "pagerange": "513-523", "id_number": "CaltechAUTHORS:20220615-944206900", "issn": "2520-1158", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20220615-944206900", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Office of Naval Research (ONR)", "grant_number": "N000141812155" }, { "agency": "Department of Energy (DOE)", "grant_number": "DE-SC0012704" }, { "agency": "NSF", "grant_number": "DMR-2011967" }, { "agency": "NSF", "grant_number": "CBET-1805022" }, { "agency": "NSF", "grant_number": "CBET-2005250" } ] }, "other_numbering_system": { "items": [ { "id": "1521", "name": "WAG" } ] }, "doi": "10.1038/s41929-022-00797-0", "primary_object": { "basename": "41929_2022_797_MOESM1_ESM.pdf", "url": "https://authors.library.caltech.edu/records/5rf5x-8tj69/files/41929_2022_797_MOESM1_ESM.pdf" }, "related_objects": [ { "basename": "41929_2022_797_MOESM2_ESM.txt", "url": "https://authors.library.caltech.edu/records/5rf5x-8tj69/files/41929_2022_797_MOESM2_ESM.txt" }, { "basename": "41929_2022_797_MOESM3_ESM.txt", "url": "https://authors.library.caltech.edu/records/5rf5x-8tj69/files/41929_2022_797_MOESM3_ESM.txt" } ], "resource_type": "article", "pub_year": "2022", "author_list": "Huang, Jin; Sementa, Luca; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/hk7a2-4jx68", "eprint_id": 115571, "eprint_status": "archive", "datestamp": "2023-08-20 07:40:29", "lastmod": "2023-10-24 16:35:38", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Farhang-Alexander-R", "name": { "family": "Farhang", "given": "Alexander R." } }, { "id": "Bernstein-Jeremy-D", "name": { "family": "Bernstein", "given": "Jeremy D." }, "orcid": "0000-0001-9110-7476" }, { "id": "Tirumala-Kushal", "name": { "family": "Tirumala", "given": "Kushal" } }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Yue-Yisong", "name": { "family": "Yue", "given": "Yisong" }, "orcid": "0000-0001-9127-1989" } ] }, "title": "Investigating Generalization by Controlling Normalized Margin", "ispublished": "pub", "full_text_status": "public", "note": "\u00a9 2022 by the authors. \n\nThe authors are grateful to the anonymous reviewers for their helpful comments. This material is based upon work supported by the National Science Foundation Graduate Research Fellowship under Grant No. DGE-1745301. This material was also supported by the following grants: NSF #1918865; ONR N00014-21-1-2483.\n\nPublished - farhang22a.pdf
Submitted - 2205.03940.pdf
Supplemental Material - farhang22a-supp.zip
", "abstract": "Weight norm \u2016w\u2016 and margin \u03b3 participate in learning theory via the normalized margin \u03b3/\u2016w\u2016. Since standard neural net optimizers do not control normalized margin, it is hard to test whether this quantity causally relates to generalization. This paper designs a series of experimental studies that explicitly control normalized margin and thereby tackle two central questions. First: does normalized margin always have a causal effect on generalization? The paper finds that no -- networks can be produced where normalized margin has seemingly no relationship with generalization, counter to the theory of Bartlett et al. (2017). Second: does normalized margin ever have a causal effect on generalization? The paper finds that yes -- in a standard training setup, test performance closely tracks normalized margin. The paper suggests a Gaussian process model as a promising explanation for this behavior.", "date": "2022-05-08", "date_type": "published", "publication": "Proceedings of Machine Learning Research", "volume": "162", "publisher": "ML Research Press", "pagerange": "6324-6336", "id_number": "CaltechAUTHORS:20220714-212426792", "issn": "2640-3498", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20220714-212426792", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NSF Graduate Research Fellowship", "grant_number": "DGE-1745301" }, { "agency": "NSF", "grant_number": "CCF-1918865" }, { "agency": "Office of Naval Research (ONR)", "grant_number": "N00014-21-1-2483" } ] }, "doi": "10.48550/arXiv.arXiv.2205.03940", "primary_object": { "basename": "2205.03940.pdf", "url": "https://authors.library.caltech.edu/records/hk7a2-4jx68/files/2205.03940.pdf" }, "related_objects": [ { "basename": "farhang22a-supp.zip", "url": "https://authors.library.caltech.edu/records/hk7a2-4jx68/files/farhang22a-supp.zip" }, { "basename": "farhang22a.pdf", "url": "https://authors.library.caltech.edu/records/hk7a2-4jx68/files/farhang22a.pdf" } ], "resource_type": "article", "pub_year": "2022", "author_list": "Farhang, Alexander R.; Bernstein, Jeremy D.; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/dkw5a-pk181", "eprint_id": 108202, "eprint_status": "archive", "datestamp": "2023-08-20 03:55:45", "lastmod": "2023-12-22 23:20:43", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Bernstein-Jeremy-D", "name": { "family": "Bernstein", "given": "Jeremy" }, "orcid": "0000-0001-9110-7476" }, { "id": "Meister-M", "name": { "family": "Meister", "given": "Markus" }, "orcid": "0000-0003-2136-6506" }, { "id": "Yue-Yisong", "name": { "family": "Yue", "given": "Yisong" }, "orcid": "0000-0001-9127-1989" } ] }, "title": "Learning by Turning: Neural Architecture Aware Optimisation", "ispublished": "pub", "full_text_status": "public", "note": "\u00a9 2021 by the authors.\n\nPublished - liu21c.pdf
Submitted - 2102.07227.pdf
", "abstract": "Descent methods for deep networks are notoriously capricious: they require careful tuning of step size, momentum and weight decay, and which method will work best on a new benchmark is a priori unclear. To address this problem, this paper conducts a combined study of neural architecture and optimisation, leading to a new optimiser called Nero: the neuronal rotator. Nero trains reliably without momentum or weight decay, works in situations where Adam and SGD fail, and requires little to no learning rate tuning. Also, Nero's memory footprint is square root that of Adam or LAMB. Nero combines two ideas: (1) projected gradient descent over the space of balanced networks; (2) neuron-specific updates, where the step size sets the angle through which each neuron's hyperplane turns. The paper concludes by discussing how this geometric connection between architecture and optimisation may impact theories of generalisation in deep learning.", "date": "2021-07", "date_type": "published", "publication": "Proceedings of Machine Learning Research", "volume": "139", "publisher": "ML Research Press", "pagerange": "6748-6758", "id_number": "CaltechAUTHORS:20210225-132711583", "issn": "2640-3498", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20210225-132711583", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "local_group": { "items": [ { "id": "Division-of-Biology-and-Biological-Engineering" } ] }, "doi": "10.48550/arXiv.2102.07227", "primary_object": { "basename": "2102.07227.pdf", "url": "https://authors.library.caltech.edu/records/dkw5a-pk181/files/2102.07227.pdf" }, "related_objects": [ { "basename": "liu21c.pdf", "url": "https://authors.library.caltech.edu/records/dkw5a-pk181/files/liu21c.pdf" } ], "resource_type": "article", "pub_year": "2021", "author_list": "Liu, Yang; Bernstein, Jeremy; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/t3df1-gzb61", "eprint_id": 103461, "eprint_status": "archive", "datestamp": "2023-08-19 18:49:00", "lastmod": "2023-12-13 17:01:09", "type": "monograph", "metadata_visibility": "show", "creators": { "items": [ { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" } }, { "id": "Perona-P", "name": { "family": "Perona", "given": "Pietro" }, "orcid": "0000-0002-7583-5809" }, { "id": "Meister-M", "name": { "family": "Meister", "given": "Markus" }, "orcid": "0000-0003-2136-6506" } ] }, "title": "PanDA: Panoptic Data Augmentation", "ispublished": "unpub", "full_text_status": "public", "keywords": "Data Augmentation, Panoptic Segmentation, Scene Understanding, Image Synthesis", "note": "Submitted - 1911.12317.pdf
", "abstract": "The recently proposed panoptic segmentation task presents a significant challenge of image understanding with computer vision by unifying semantic segmentation and instance segmentation tasks. In this paper we present an efficient and novel panoptic data augmentation (PanDA) method which operates exclusively in pixel space, requires no additional data or training, and is computationally cheap to implement. By retraining original state-of-the-art models on PanDA augmented datasets generated with a single frozen set of parameters, we show robust performance gains in panoptic segmentation, instance segmentation, as well as detection across models, backbones, dataset domains, and scales. Finally, the effectiveness of unrealistic-looking training images synthesized by PanDA suggest that one should rethink the need for image realism for efficient data augmentation.", "date": "2020-05-26", "date_type": "published", "publisher": "arXiv", "id_number": "CaltechAUTHORS:20200526-134149667", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20200526-134149667", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "local_group": { "items": [ { "id": "Division-of-Biology-and-Biological-Engineering" } ] }, "doi": "10.48550/arXiv.1911.12317", "primary_object": { "basename": "1911.12317.pdf", "url": "https://authors.library.caltech.edu/records/t3df1-gzb61/files/1911.12317.pdf" }, "resource_type": "monograph", "pub_year": "2020", "author_list": "Liu, Yang; Perona, Pietro; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/knyj1-fks47", "eprint_id": 103465, "eprint_status": "archive", "datestamp": "2023-08-19 20:22:52", "lastmod": "2023-12-22 23:20:37", "type": "book_section", "metadata_visibility": "show", "creators": { "items": [ { "id": "Beery-S", "name": { "family": "Beery", "given": "Sara" }, "orcid": "0000-0002-2544-1844" }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" } }, { "id": "Morris-Dan", "name": { "family": "Morris", "given": "Dan" } }, { "id": "Piavis-J", "name": { "family": "Piavis", "given": "Jim" } }, { "id": "Kapoor-Ashish", "name": { "family": "Kapoor", "given": "Ashish" } }, { "id": "Meister-M", "name": { "family": "Meister", "given": "Markus" }, "orcid": "0000-0003-2136-6506" }, { "id": "Joshi-Neel", "name": { "family": "Joshi", "given": "Neel" } }, { "id": "Perona-P", "name": { "family": "Perona", "given": "Pietro" }, "orcid": "0000-0002-7583-5809" } ] }, "title": "Synthetic Examples Improve Generalization for Rare Classes", "ispublished": "unpub", "full_text_status": "public", "note": "\u00a9 2020 IEEE. \n\nWe would like to thank the USGS and NPS for providing data. This work was supported by NSFG RFP Grant No. 1745301, the views are those of the authors and do not necessarily reflect the views of the NSF. Compute provided by Microsoft AI for Earth and AWS.\n\nSubmitted - 1904.05916.pdf
", "abstract": "The ability to detect and classify rare occurrences in images has important applications - for example, counting rare and endangered species when studying biodiversity, or detecting infrequent traffic scenarios that pose a danger to self-driving cars. Few-shot learning is an open problem: current computer vision systems struggle to categorize objects they have seen only rarely during training, and collecting a sufficient number of training examples of rare events is often challenging and expensive, and sometimes outright impossible. We explore in depth an approach to this problem: complementing the few available training images with ad-hoc simulated data.Our testbed is animal species classification, which has a real-world long-tailed distribution. We present two natural world simulators, and analyze the effect of different axes of variation in simulation, such as pose, lighting, model, and simulation method, and we prescribe best practices for efficiently incorporating simulated data for real-world performance gain. Our experiments reveal that synthetic data can considerably reduce error rates for classes that are rare, that as the amount of simulated data is increased, accuracy on the target class improves, and that high variation of simulated data provides maximum performance gain.", "date": "2020-03", "date_type": "published", "publisher": "IEEE", "place_of_pub": "Piscataway, NJ", "pagerange": "852-862", "id_number": "CaltechAUTHORS:20200526-140034764", "isbn": "978-1-7281-6553-0", "book_title": "2020 IEEE Winter Conference on Applications of Computer Vision (WACV)", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20200526-140034764", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NSF Graduate Research Fellowship", "grant_number": "DGE-1745301" }, { "agency": "Microsoft AI for Earth" }, { "agency": "Amazon Web Services" } ] }, "local_group": { "items": [ { "id": "Division-of-Biology-and-Biological-Engineering" } ] }, "doi": "10.1109/WACV45572.2020.9093570", "primary_object": { "basename": "1904.05916.pdf", "url": "https://authors.library.caltech.edu/records/knyj1-fks47/files/1904.05916.pdf" }, "resource_type": "book_section", "pub_year": "2020", "author_list": "Beery, Sara; Liu, Yang; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/pk4gj-cf438", "eprint_id": 93393, "eprint_status": "archive", "datestamp": "2023-08-19 14:42:29", "lastmod": "2023-10-20 17:06:27", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Ma-Chi-Geology", "name": { "family": "Ma", "given": "Chi" }, "orcid": "0000-0002-1828-7033" }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" } ] }, "title": "Discovery of a zinc-rich mineral on the surface of lunar orange pyroclastic beads", "ispublished": "pub", "full_text_status": "public", "keywords": "Lunar orange beads, volcanic gas, vapor condensates, the Moon, zinc-rich mineral, gordaite", "note": "\u00a9 2019 Mineralogical Society of America. \n\nY.L. acknowledges the partial support by NASA Cosmochemistry grant NNN13D465T. SEM, EDS, and EBSD analyses were carried out at the Caltech GPS Division Analytical Facility, which is supported, in part, by NSF Grants EAR-0318518 and DMR-0080065. \n\nA portion of the work was performed at Jet Propulsion Laboratory, which is managed by California Institute of Technology (Caltech) under a contract with NASA. We thank Ryan Zeigler, Linda Watts, and Andrea Mosie from JSC Lunar Curation Office for tracking down the process history of samples allocated for this work, George Rossman for running Raman analysis on the Zn-rich mineral, and Liong Ma for helping with SEM and EDS analyses. We are grateful to the constructive comments by an anonymous reviewer, and by David Pyle and Ts. Stanimirova.\n\nSupplemental Material - AM-19-36896.zip
", "abstract": "We present the first discovery of a Zn-rich mineral on the pristine surface of orange pyroclastic beads from Apollo sample 74220. This Zn-rich mineral is wide occurring, trigonal or hexagonal in shape, with a normalized composition of ~59 wt% Zn, ~26 wt% O (calculated), ~6 wt% S, ~5 wt% Na, and ~4 wt% Cl. The crystal morphology, homogeneity, and chemistry of individual grains are most consistent with gordaite, a zinc chlorohydroxosulfate mineral, showing an empirical formula of Na_(1.02)Zn_(3.98)[(SO_4)_(0.84)(OH)_(0.30)](OH)_6[Cl_(0.50)(OH)_(0.50)]\u00b7nH_2O, albeit the exact amounts of OH and H_2O are uncertain. The pristine 74220 sample used in this study was only directly exposed to air for a cumulative period of 18 days before our study. The same Zn-rich crystals, examined 12 to 15 months apart, show no visible physical and chemical changes. Thus, this zinc-rich mineral likely formed through rapid alteration (oxidation and hydration) by terrestrial air of the original vapor-deposited Zn, Cl, S, and Na-bearing solids. The composition of the zinc-rich mineral indicates that the vapor condensates consist of metallic Zn and metallic Na with either ZnS or native S, and either ZnCl_2 or NaCl. This is the first direct evidence that metallic Zn and Na are key components in the vapor condensates of lunar volcanic gas, which implies lunar volcanic gas may be under higher pressure than previously thought, and the gas composition may be different than previously inferred. Our study is also relevant to the collection, handling, curation, and sample preparation of returned samples from other planetary bodies.", "date": "2019-03-01", "date_type": "published", "publication": "American Mineralogist", "volume": "104", "number": "3", "publisher": "Mineralogical Society of America", "pagerange": "447-452", "id_number": "CaltechAUTHORS:20190301-110729511", "issn": "0003-004X", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20190301-110729511", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NASA", "grant_number": "NNN13D465T" }, { "agency": "NSF", "grant_number": "EAR-0318518" }, { "agency": "NSF", "grant_number": "DMR-0080065" }, { "agency": "NASA/JPL/Caltech" } ] }, "doi": "10.2138/am-2019-6896", "primary_object": { "basename": "AM-19-36896.zip", "url": "https://authors.library.caltech.edu/records/pk4gj-cf438/files/AM-19-36896.zip" }, "resource_type": "article", "pub_year": "2019", "author_list": "Ma, Chi and Liu, Yang" }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/2ftqt-zd927", "eprint_id": 90520, "eprint_status": "archive", "datestamp": "2023-08-19 12:50:09", "lastmod": "2023-10-23 15:45:29", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Stiles-N-R-B", "name": { "family": "Stiles", "given": "Noelle R. B." }, "orcid": "0000-0002-7352-5815" }, { "id": "Meister-M", "name": { "family": "Meister", "given": "Markus" }, "orcid": "0000-0003-2136-6506" } ] }, "title": "Augmented Reality Powers a Cognitive Assistant for the Blind", "ispublished": "pub", "full_text_status": "public", "note": "\u00a9 2017 Liu et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. \n\nReceived: 24 April 2018; Accepted: 27 October 2018; Published: 27 November 2018. \n\nData and materials availability: Data and code that produced the figures are available on the Dryad Digital Repository. \n\nData availability: All data generated or analysed during this study are included in the manuscript and supporting files. Source data files for all figures have been deposited in Dryad. Additional code is published on a Github repository (https://github.com/meisterlabcaltech/CARA_Public; copy archived at https://github.com/elifesciences-publications/CARA_Public). \n\nSupported by grant 103212 from the Shurl and Kay Curci Foundation. We thank Ralph Adolphs, David Anderson, and Shin Shimojo for comments on the manuscript, and Kristina Dylla for posing for Figure 1A and field testing all of the tasks. \n\nAuthor contributions: Yang Liu, Conceptualization, Data curation, Software, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing\u2014review and editing; Noelle RB Stiles, Resources, Validation, Investigation, Methodology; Markus Meister, Conceptualization, Supervision, Funding acquisition, Writing\u2014original draft, Project administration, Writing\u2014review and editing. \n\nEthics: Human subjects: All procedures involving human subjects were reviewed and approved by the Institutional Review Board at Caltech, Human Subjects Protocol 16-0663. All subjects gave their informed consent to the experiments, and where applicable to publication of videos that accompany this article.\n\nPublished - elife-37841-v1.pdf
Submitted - 321265.full.pdf
Supplemental Material - elife-37841-transrepform-v1.pdf
", "abstract": "To restore vision for the blind, several prosthetic approaches have been explored that convey raw images to the brain. So far, these schemes all suffer from a lack of bandwidth. An alternate approach would restore vision at the cognitive level, bypassing the need to convey sensory data. A wearable computer captures video and other data, extracts important scene knowledge, and conveys that to the user in compact form. Here, we implement an intuitive user interface for such a device using augmented reality: each object in the environment has a voice and communicates with the user on command. With minimal training, this system supports many aspects of visual cognition: obstacle avoidance, scene understanding, formation and recall of spatial memories, navigation. Blind subjects can traverse an unfamiliar multi-story building on their first attempt. To spur further development in this domain, we developed an open-source environment for standardized benchmarking of visual assistive devices.", "date": "2018-11-28", "date_type": "published", "publication": "eLife", "volume": "7", "publisher": "eLife Sciences Publications", "pagerange": "Art. No. e37841", "id_number": "CaltechAUTHORS:20181030-140944700", "issn": "2050-084X", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20181030-140944700", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Shurl and Kay Curci Foundation", "grant_number": "103212" } ] }, "doi": "10.7554/eLife.37841.001", "pmcid": "PMC6257813", "primary_object": { "basename": "elife-37841-transrepform-v1.pdf", "url": "https://authors.library.caltech.edu/records/2ftqt-zd927/files/elife-37841-transrepform-v1.pdf" }, "related_objects": [ { "basename": "elife-37841-v1.pdf", "url": "https://authors.library.caltech.edu/records/2ftqt-zd927/files/elife-37841-v1.pdf" }, { "basename": "321265.full.pdf", "url": "https://authors.library.caltech.edu/records/2ftqt-zd927/files/321265.full.pdf" } ], "resource_type": "article", "pub_year": "2018", "author_list": "Liu, Yang; Stiles, Noelle R. B.; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/ffm79-m1w48", "eprint_id": 98200, "eprint_status": "archive", "datestamp": "2023-08-22 00:08:28", "lastmod": "2023-10-18 17:08:48", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Diner-D-J", "name": { "family": "Diner", "given": "David J." }, "orcid": "0000-0001-8102-7616" }, { "id": "Boland-S-W", "name": { "family": "Boland", "given": "Stacey W." } }, { "id": "Brauer-M", "name": { "family": "Brauer", "given": "Michael" } }, { "id": "Bruegge-C-J", "name": { "family": "Bruegge", "given": "Carol" } }, { "id": "Burke-K-A", "name": { "family": "Burke", "given": "Kevin A." } }, { "id": "Chipman-R-A", "name": { "family": "Chipman", "given": "Russell" } }, { "id": "Di-Girolamo-L", "name": { "family": "Di Girolamo", "given": "Larry" } }, { "id": "Garay-M-J", "name": { "family": "Garay", "given": "Michael J." }, "orcid": "0000-0002-1374-5074" }, { "id": "Hasheminassab-S", "name": { "family": "Hasheminassab", "given": "Sina" } }, { "id": "Hyer-E", "name": { "family": "Hyer", "given": "Edward" } }, { "id": "Jerrett-M", "name": { "family": "Jerrett", "given": "Michael" } }, { "id": "Jovanovic-V-M", "name": { "family": "Jovanovic", "given": "Veljko" } }, { "id": "Kalashnikova-O-V", "name": { "family": "Kalashnikova", "given": "Olga V." }, "orcid": "0000-0002-1330-1529" }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Lyapustin-A-I", "name": { "family": "Lyapustin", "given": "Alexei I." } }, { "id": "Martin-R-V", "name": { "family": "Martin", "given": "Randall V." } }, { "id": "Nastan-A", "name": { "family": "Nastan", "given": "Abigail" } }, { "id": "Ostro-Bart-D", "name": { "family": "Ostro", "given": "Bart D." } }, { "id": "Ritz-B", "name": { "family": "Ritz", "given": "Beate" } }, { "id": "Schwartz-J", "name": { "family": "Schwartz", "given": "Joel" } }, { "id": "Wang-Jun", "name": { "family": "Wang", "given": "Jun" } }, { "id": "Xu-Feng", "name": { "family": "Xu", "given": "Feng" }, "orcid": "0000-0001-5155-9478" } ] }, "title": "Advances in multiangle satellite remote sensing of speciated airborne particulate matter and association with adverse health effects: from MISR to MAIA", "ispublished": "pub", "full_text_status": "public", "keywords": "particulate matter; aerosols; remote sensing; human health", "note": "\u00a9 2018 The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. \n \nPaper 180287SS received Apr. 7, 2018; accepted for publication Jun. 26, 2018; published online Jul. 28, 2018. \n\nThe authors acknowledge the participation of a multidisciplinary team in the MAIA investigation, including experts in system engineering, instrument design and fabrication, project and resource management, data systems, instrument operations, aerosol and cloud remote sensing, epidemiology, and public health. Specific mention is given to our collaborators Bert Brunekreef (Utrecht University), Sagnik Dey (IIT Delhi), Kembra Howdeshell (National Institute of Environmental Health Sciences), John Langstaff (EPA), Pius Lee (National Oceanic and Atmospheric Administration), and Fuyuen Yip (Centers for Disease Control and Prevention), as well as many local personnel in the various PTAs who will assist with various aspects of the project. This paper represents the current development status of the MAIA investigation. The decision to implement MAIA will not be finalized until NASA completes the National Environmental Policy Act (NEPA) process. This research is carried out, in part, at the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautics and Space Administration (NASA). The data in Fig. 1 were obtained from the NASA Langley Research Center Atmospheric Science Data Center. \n\nThe authors declare that there are no conflicts of interest.\n\nPublished - 042603_1.pdf
", "abstract": "Inhalation of airborne particulate matter (PM) is associated with a variety of adverse health outcomes. However, the relative toxicity of specific PM types\u2014mixtures of particles of varying sizes, shapes, and chemical compositions\u2014is not well understood. A major impediment has been the sparse distribution of surface sensors, especially those measuring speciated PM. Aerosol remote sensing from Earth orbit offers the opportunity to improve our understanding of the health risks associated with different particle types and sources. The Multi-angle Imaging SpectroRadiometer (MISR) instrument aboard NASA's Terra satellite has demonstrated the value of near-simultaneous observations of backscattered sunlight from multiple view angles for remote sensing of aerosol abundances and particle properties over land. The Multi-Angle Imager for Aerosols (MAIA) instrument, currently in development, improves on MISR's sensitivity to airborne particle composition by incorporating polarimetry and expanded spectral range. Spatiotemporal regression relationships generated using collocated surface monitor and chemical transport model data will be used to convert fractional aerosol optical depths retrieved from MAIA observations to near-surface PM_(10), PM_(2.5), and speciated PM_(2.5). Health scientists on the MAIA team will use the resulting exposure estimates over globally distributed target areas to investigate the association of particle species with population health effects.", "date": "2018-10", "date_type": "published", "publication": "Journal of Applied Remote Sensing", "volume": "12", "number": "4", "publisher": "Society of Photo-optical Instrumentation Engineers", "pagerange": "Art. No. 042603", "id_number": "CaltechAUTHORS:20190823-160034580", "issn": "1931-3195", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20190823-160034580", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NASA/JPL/Caltech" } ] }, "doi": "10.1117/1.jrs.12.042603", "primary_object": { "basename": "042603_1.pdf", "url": "https://authors.library.caltech.edu/records/ffm79-m1w48/files/042603_1.pdf" }, "resource_type": "article", "pub_year": "2018", "author_list": "Diner, David J.; Boland, Stacey W.; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/xrxt5-xxz04", "eprint_id": 84158, "eprint_status": "archive", "datestamp": "2023-08-19 05:51:12", "lastmod": "2023-10-18 15:13:44", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Lu-Naiwei", "name": { "family": "Lu", "given": "Naiwei" } }, { "id": "Beer-M", "name": { "family": "Beer", "given": "Michael" } }, { "id": "Noori-M", "name": { "family": "Noori", "given": "Mohammad" } }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" } ] }, "title": "Lifetime Deflections of Long-Span Bridges under Dynamic and Growing Traffic Loads", "ispublished": "pub", "full_text_status": "public", "note": "\u00a9 2017 American Society of Civil Engineers.", "abstract": "Steady traffic growth may pose a safety hazard to in-service bridges, especially long-span bridges subjected to the simultaneous presence of multiple heavy-duty trucks. This study presents a methodology for evaluating the statistical extrapolation of traffic-load effects on long-span bridges. As part of the contributions advancing the state of the art, this study addresses several challenging issues, including traffic growth, and the resulting dynamic impact, and actual traffic patterns. The nonstationarity of the traffic-load effects due to traffic growth is considered in a series system compounded by several interval traffic models. The dynamic impacts of traffic loads were simulated by a traffic-bridge-coupled vibration system, and the statistical characteristics were captured using a level-crossing model. The actual traffic pattern was simulated by stochastic traffic flows on the basis of the statistics of the weigh-in-motion measurements of a highway bridge. Two numerical examples show the ability of the interval-traffic-growth model to capture the nonstationarity of the growing traffic loads. In addition, a case study of a long-span suspension bridge shows the effectiveness of implementing the proposed methodology for the statistical extrapolation of the maximum deflection. The numerical results of the case study also reveal that the degradation of road-roughness conditions leads to more level crossings but also results in a slight increase in the extrapolation of the deflection. However, traffic growth results in rapid increases in both the extrapolated deflection and the probability of exceedance of the deflection limit.", "date": "2017-11", "date_type": "published", "publication": "Journal of Bridge Engineering", "volume": "22", "number": "11", "publisher": "American Society of Civil Engineers", "pagerange": "Art. No. 04017086", "id_number": "CaltechAUTHORS:20180108-084919868", "issn": "1084-0702", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180108-084919868", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "doi": "10.1061/(ASCE)BE.1943-5592.0001125", "resource_type": "article", "pub_year": "2017", "author_list": "Lu, Naiwei; Beer, Michael; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/jemzb-z2h17", "eprint_id": 74672, "eprint_status": "archive", "datestamp": "2023-08-19 00:50:40", "lastmod": "2023-10-24 22:50:50", "type": "book_section", "metadata_visibility": "show", "creators": { "items": [ { "id": "Cook-C-A", "name": { "family": "Cook", "given": "Colin A." }, "orcid": "0000-0002-6283-5105" }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Lu-Jianming", "name": { "family": "Lu", "given": "Jianming" } }, { "id": "Chen-Nanhai", "name": { "family": "Chen", "given": "Nanhai" } }, { "id": "Fong-Yuman", "name": { "family": "Fong", "given": "Yuman" } }, { "id": "Tai-Yu-Chong", "name": { "family": "Tai", "given": "Yu-Chong" }, "orcid": "0000-0001-8529-106X" } ] }, "title": "Gas perfusable microfabricated membranes for high-density cell culture", "ispublished": "unpub", "full_text_status": "restricted", "note": "\u00a9 2017 IEEE. \n\nThanks to the Caltech MEMS Lab members for their guidance with techniques and fabrication. In memory of Lillian Boasie and Gweneth Goodman.", "abstract": "We report for the first time the design, fabrication, and feasibility of a high-density cell culture system capable of a cell substrate density of 40 cm^2/cm^3, greater than 250\u00d7 current commercially available systems. This design provides oxygen directly from gas perfusable membranes on which the cells are grown to overcome oxygen delivery limitations in traditional culture systems. With translation in mind, the membranes are composed only of medical grade PDMS and Parylene to mitigate contaminant leaching concerns.", "date": "2017-01", "date_type": "published", "publisher": "IEEE", "place_of_pub": "Piscataway, NJ", "pagerange": "472-475", "id_number": "CaltechAUTHORS:20170302-134637147", "isbn": "978-1-5090-5078-9", "book_title": "IEEE 30th International Conference on Micro Electro Mechanical Systems", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20170302-134637147", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "doi": "10.1109/MEMSYS.2017.7863445", "resource_type": "book_section", "pub_year": "2017", "author_list": "Cook, Colin A.; Liu, Yang; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/7rz99-2d674", "eprint_id": 70996, "eprint_status": "archive", "datestamp": "2023-08-22 19:11:32", "lastmod": "2023-10-23 15:15:19", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Baziotis-I-P", "name": { "family": "Baziotis", "given": "Ioannis P." } }, { "id": "Asimow-P-D", "name": { "family": "Asimow", "given": "Paul D." }, "orcid": "0000-0001-6025-8925" }, { "id": "Bodnar-R-J", "name": { "family": "Bodnar", "given": "Robert J." } }, { "id": "Taylor-L-A", "name": { "family": "Taylor", "given": "Lawrence A." } } ] }, "title": "Mineral chemistry of the Tissint meteorite: Indications of two-stage crystallization in a closed system", "ispublished": "pub", "full_text_status": "public", "note": "\u00a9 2016 Meteoritical Society. \n\nReceived 04 February 2016; revision accepted 10 July 2016. Version of Record online: 5 Oct 2016. \n\nWe thank Allan Patchen and Luca Fedele for their assistance with data collection. Comments from the AE (C. Goodrich), T. Usui, C. Herd, and M. McCanta on earlier versions of the manuscript have significantly improved the presentation and are greatly appreciated. We acknowledge partial support by NASA Cosmochemistry grants NNX11AG58G to LAT, NNN13D465T to YL, NSF Grant EAR-1226270 to PDA, and NSF Grant EAR-1019770 to RJB. YL is supported by the Jet Propulsion Laboratory, which is managed by the California Institute of Technology under a contract with NASA.\n\nPublished - Liu_et_al-2016-Meteoritics___Planetary_Science.pdf
Supplemental Material - maps12726-sup-0001-SupInfo.docx
", "abstract": "The Tissint meteorite is a geochemically depleted, olivine-phyric shergottite. Olivine megacrysts contain 300\u2013600 \u03bcm cores with uniform Mg# (~80 \u00b1 1) followed by concentric zones of Fe-enrichment toward the rims. We applied a number of tests to distinguish the relationship of these megacrysts to the host rock. Major and trace element compositions of the Mg-rich core in olivine are in equilibrium with the bulk rock, within uncertainty, and rare earth element abundances of melt inclusions in Mg-rich olivines reported in the literature are similar to those of the bulk rock. Moreover, the P K\u03b1 intensity maps of two large olivine grains show no resorption between the uniform core and the rim. Taken together, these lines of evidence suggest the olivine megacrysts are phenocrysts. Among depleted olivine-phyric shergottites, Tissint is the first one that acts mostly as a closed system with olivine megacrysts being the phenocrysts. The texture and mineral chemistry of Tissint indicate a crystallization sequence of: olivine (Mg# 80 \u00b1 1) \u2192 olivine (Mg# 76) + chromite \u2192 olivine (Mg# 74) + Ti-chromite \u2192 olivine (Mg# 74\u201363) + pyroxene (Mg# 76\u201365) + Cr-ulv\u00f6spinel \u2192 olivine (Mg# 63\u201335) + pyroxene (Mg# 65\u201360) + plagioclase, followed by late-stage ilmenite and phosphate. The crystallization of the Tissint meteorite likely occurred in two stages: uniform olivine cores likely crystallized under equilibrium conditions; and a fractional crystallization sequence that formed the rest of the rock. The two-stage crystallization without crystal settling is simulated using MELTS and the Tissint bulk composition, and can broadly reproduce the crystallization sequence and mineral chemistry measured in the Tissint samples. The transition between equilibrium and fractional crystallization is associated with a dramatic increase in cooling rate and might have been driven by an acceleration in the ascent rate or by encounter with a steep thermal gradient in the Martian crust.", "date": "2016-12", "date_type": "published", "publication": "Meteoritics and Planetary Science", "volume": "51", "number": "12", "publisher": "Meteoritical Society", "pagerange": "2293-2315", "id_number": "CaltechAUTHORS:20161011-120243183", "issn": "1086-9379", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20161011-120243183", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NASA", "grant_number": "NNX11AG58G" }, { "agency": "NASA", "grant_number": "NNN13D465T" }, { "agency": "NSF", "grant_number": "EAR-1226270" }, { "agency": "NSF", "grant_number": "EAR-1019770" }, { "agency": "NASA/JPL/Caltech" } ] }, "local_group": { "items": [ { "id": "Division-of-Geological-and-Planetary-Sciences" } ] }, "doi": "10.1111/maps.12726", "primary_object": { "basename": "Liu_et_al-2016-Meteoritics___Planetary_Science.pdf", "url": "https://authors.library.caltech.edu/records/7rz99-2d674/files/Liu_et_al-2016-Meteoritics___Planetary_Science.pdf" }, "related_objects": [ { "basename": "maps12726-sup-0001-SupInfo.docx", "url": "https://authors.library.caltech.edu/records/7rz99-2d674/files/maps12726-sup-0001-SupInfo.docx" } ], "resource_type": "article", "pub_year": "2016", "author_list": "Liu, Yang; Baziotis, Ioannis P.; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/27a1x-ks354", "eprint_id": 72854, "eprint_status": "archive", "datestamp": "2023-08-20 14:22:24", "lastmod": "2023-10-23 23:01:03", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Howarth-G-H", "name": { "family": "Howarth", "given": "Geoffrey H." } }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Chen-Yang", "name": { "family": "Chen", "given": "Yang" }, "orcid": "0000-0002-8964-0084" }, { "id": "Pernet-Fisher-J-F", "name": { "family": "Pernet-Fisher", "given": "John F." } }, { "id": "Taylor-L-A", "name": { "family": "Taylor", "given": "Lawrence A." } } ] }, "title": "Postcrystallization metasomatism in shergottites: Evidence from the paired meteorites LAR 06319 and LAR 12011", "ispublished": "pub", "full_text_status": "public", "note": "\u00a9 2016 The Meteoritical Society. \n\nIssue online: 8 November 2016; Version of record online: 15 March 2016; Manuscript Accepted: 12 October 2015; Manuscript Received: 22 June 2015. \n\nThis work was supported by NASA Cosmochemistry grant NNX11AG58G, awarded to LAT. We thank Allen Patchen for assistance with electron microprobe analyses. YL acknowledge the partial support by NASA Cosmochemistry grants NNN13D465T, and support from the Jet Propulsion Laboratory, which is managed by the California Institute of Technology under the contract with NASA. We are extremely grateful to Francis McCubbin and Justin Filiberto for detailed and thorough reviews, which greatly aided the overall content and discussion of this manuscript. We also thank Cyrena Goodrich for editorial handling.\n\nPublished - Howarth_et_al-2016-Meteoritics___Planetary_Science.pdf
Supplemental Material - maps12576-sup-0001-DataS1.xlsx
", "abstract": "Apatite is the major volatile-bearing phase in Martian meteorites, containing structurally bound fluorine, chlorine, and hydroxyl ions. In apatite, F is more compatible than Cl, which in turn is more compatible than OH. During degassing, Cl strongly partitions into the exsolved phase, whereas F remains in the melt. For these reasons, the volatile concentrations within apatite are predictable during magmatic differentiation and degassing. Here, we present compositional data for apatite and merrillite in the paired enriched, olivine-phyric shergottites LAR 12011 and LAR 06319. In addition, we calculate the relative volatile fugacities of the parental melts at the time of apatite formation. The apatites are dominantly OH-rich (calculated by stoichiometry) with variable yet high Cl contents. Although several other studies have found evidence for degassing in the late-stage mineral assemblage of LAR 06319, the apatite evolutionary trends cannot be reconciled with this interpretation. The variable Cl contents and high OH contents measured in apatites are not consistent with fractionation either. Volatile fugacity calculations indicate that water and fluorine activities remain relatively constant, whereas there is a large variation in the chlorine activity. The Martian crust is Cl-rich indicating that changes in Cl contents in the apatites may be related to an external crustal source. We suggest that the high and variable Cl contents and high OH contents of the apatite are the results of postcrystallization interaction with Cl-rich, and possibly water-rich, crustal fluids circulating in the Martian crust.", "date": "2016-11", "date_type": "published", "publication": "Meteoritics and Planetary Science", "volume": "51", "number": "11", "publisher": "Meteoritical Society", "pagerange": "2061-2072", "id_number": "CaltechAUTHORS:20161215-133942960", "issn": "1086-9379", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20161215-133942960", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NASA", "grant_number": "NNX11AG58G" }, { "agency": "NASA", "grant_number": "NNN13D465T" }, { "agency": "NASA/JPL/Caltech" } ] }, "doi": "10.1111/maps.12576", "primary_object": { "basename": "Howarth_et_al-2016-Meteoritics___Planetary_Science.pdf", "url": "https://authors.library.caltech.edu/records/27a1x-ks354/files/Howarth_et_al-2016-Meteoritics___Planetary_Science.pdf" }, "related_objects": [ { "basename": "maps12576-sup-0001-DataS1.xlsx", "url": "https://authors.library.caltech.edu/records/27a1x-ks354/files/maps12576-sup-0001-DataS1.xlsx" } ], "resource_type": "article", "pub_year": "2016", "author_list": "Howarth, Geoffrey H.; Liu, Yang; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/zw5p6-6a158", "eprint_id": 69122, "eprint_status": "archive", "datestamp": "2023-08-22 18:22:33", "lastmod": "2023-10-20 16:34:27", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Shapero-A-M", "name": { "family": "Shapero", "given": "Aubrey M." } }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Tai-Yu-Chong", "name": { "family": "Tai", "given": "Yu-Chong" }, "orcid": "0000-0001-8529-106X" } ] }, "title": "Parylene-on-oil packaging for long-term implantable pressure sensors", "ispublished": "pub", "full_text_status": "restricted", "keywords": "Packaging; Parylene; Implantable pressure sensor; Lifetime; Reliability; Long-term stability", "note": "\u00a9 2016 Springer Science+Business Media New York. \n\nThe authors would like to thank Mr. Trevor Roper for his help on all the equipment at the Caltech MEMS Lab. \n\nCompliance with ethical standards. \n\nThe authors declare that they have no conflict of interest. \n\nHuman and animal rights: This article does not contain any studies with human participants or animals performed by any of the authors.", "abstract": "This paper reports and analyzes the feasibility study of a parylene-on-oil encapsulation packaging method of pressure sensors targeted for long-term implantation. Commercial barometric digital-output pressure sensors are enclosed in silicone oil and then encapsulated in situ with parylene-C or \u2013D (PA-C, PA-D) chemical vapor deposition. Experimentally, sensors encapsulated with 30,000 cSt silicone oil and 27 \u03bcm PA-D show good performance for 6 weeks in 77 \u00b0C saline with >99 % of original sensitivity, corresponding to an extrapolated lifetime of around 21 months in 37 \u00b0C saline. This work shows that, with proper designs, such a packaging method can preserve the original pressure sensor sensitivity without offset, validated throughout accelerated lifetime tests. In experiments, wires on the prototypes are used for external electronics but it is found that they contributed to early failures, which would be absent in real wireless versions, indicating a potential for even longer lifetimes. Finally, a verified model is presented to predict the pressure sensor sensitivity of parylene-on-oil packaging with and without the presence of a bubble in the oil.", "date": "2016-08", "date_type": "published", "publication": "Biomedical Microdevices", "volume": "18", "number": "4", "publisher": "Springer", "pagerange": "Art. No. 66", "id_number": "CaltechAUTHORS:20160720-073600815", "issn": "1387-2176", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20160720-073600815", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "doi": "10.1007/s10544-016-0089-4", "resource_type": "article", "pub_year": "2016", "author_list": "Shapero, Aubrey M.; Liu, Yang; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/1vn98-jmy09", "eprint_id": 70146, "eprint_status": "archive", "datestamp": "2023-08-20 13:06:51", "lastmod": "2023-10-20 21:52:21", "type": "book_section", "metadata_visibility": "show", "creators": { "items": [ { "id": "Fraeman-A-A", "name": { "family": "Fraeman", "given": "Abigail A." }, "orcid": "0000-0003-4017-5158" }, { "id": "Ehlmann-B-L", "name": { "family": "Ehlmann", "given": "Bethany L." }, "orcid": "0000-0002-2745-3240" }, { "id": "Northwood-Smith-G-W-D", "name": { "family": "Northwood-Smith", "given": "Geraint W. D." } }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Wadhwa-M", "name": { "family": "Wadhwa", "given": "Meenakshi" }, "orcid": "0000-0001-9187-1255" }, { "id": "Greenberger-R-N", "name": { "family": "Greenberger", "given": "Rebecca N." } } ] }, "title": "Using VSWIR Microimaging Spectroscopy to Explore the Mineralogical Diversity of HED Meteorites", "ispublished": "unpub", "full_text_status": "public", "keywords": "Microimaging spectroscopy, VSWIR spectroscopy, HED meteorites, Vesta, spectral classification", "note": "\u00a9 2016 IEEE.\n\nThe research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration. \u00a9 2016. All rights reserved. Thanks to a JPL RTD grant to A.A.F. and a JPL PDF/RTD program grant to B.L.E. and D. Blaney for partial support of this work and to G. Rossman for providing samples.\n\nAccepted Version - afraeman_whispers_HED_spectroscopy_final.pdf
", "abstract": "We use VSWIR microimaging spectroscopy to survey the spectral diversity of HED meteorites at 80-\u03bcm/pixel spatial scale. Our goal in this work is both to explore the emerging capabilities of microimaging VSWIR spectroscopy and to contribute to understanding the petrologic diversity of the HED suite and the evolution of Vesta. Using a combination of manual and automated hyperspectral classification techniques, we identify four major classes of materials based on VSWIR absorptions that include pyroxene, olivine, Fe-bearing feldspars, and glass-bearing/featureless materials. Results show microimaging spectroscopy is an effective method for rapidly and non-destructively characterizing small compositional variations of meteorite samples and for locating rare phases for possible follow-up investigation. Future work will include incorporating SEM/EDS results to quantify sources of spectral variability and placing observations within a broader geologic framework of the differentiation and evolution of Vesta.", "date": "2016-08", "date_type": "published", "publisher": "IEEE", "place_of_pub": "Piscataway, NJ", "pagerange": "1-5", "id_number": "CaltechAUTHORS:20160902-094411611", "isbn": "9781538605905", "book_title": "2016 8th Workshop on Hyperspectral Image and Signal Processing: Evolution in Remote Sensing (WHISPERS)", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20160902-094411611", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NASA/JPL/Caltech" }, { "agency": "Keck Institute for Space Studies (KISS)" }, { "agency": "Caltech" }, { "agency": "JPL Research and Technology Development Fund" } ] }, "local_group": { "items": [ { "id": "Keck-Institute-for-Space-Studies" }, { "id": "Division-of-Geological-and-Planetary-Sciences" } ] }, "doi": "10.1109/WHISPERS.2016.8071804", "primary_object": { "basename": "afraeman_whispers_HED_spectroscopy_final.pdf", "url": "https://authors.library.caltech.edu/records/1vn98-jmy09/files/afraeman_whispers_HED_spectroscopy_final.pdf" }, "resource_type": "book_section", "pub_year": "2016", "author_list": "Fraeman, Abigail A.; Ehlmann, Bethany L.; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/vvjqz-gqv41", "eprint_id": 66913, "eprint_status": "archive", "datestamp": "2023-08-22 18:15:15", "lastmod": "2023-10-18 19:12:38", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Ma-Chi-Geology", "name": { "family": "Ma", "given": "Chi" }, "orcid": "0000-0002-1828-7033" }, { "id": "Tschauner-O", "name": { "family": "Tschauner", "given": "Oliver" }, "orcid": "0000-0003-3364-8906" }, { "id": "Beckett-J-R", "name": { "family": "Beckett", "given": "John R." } }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Rossman-G-R", "name": { "family": "Rossman", "given": "George R." }, "orcid": "0000-0002-4571-6884" }, { "id": "Sinogeikin-S-V", "name": { "family": "Sinogeikin", "given": "Stanislav V." } }, { "id": "Smith-J-S", "name": { "family": "Smith", "given": "Jesse S." } }, { "id": "Taylor-L-A", "name": { "family": "Taylor", "given": "Lawrence A." } } ] }, "title": "Ahrensite, \u03b3-Fe_2SiO_4, a new shock-metamorphic mineral from the Tissint meteorite: Implications for the Tissint shock event on Mars", "ispublished": "pub", "full_text_status": "public", "keywords": "Ahrensite; \u03b3-Fe_2SiO_4; New high-pressure mineral; Shock metamorphism; Nanomineral; Ringwoodite group; Tissint meteorite; Martian shergottite; Synchrotron diffraction", "note": "\u00a9 2016 Elsevier Ltd. \n\nReceived 11 July 2014; accepted in revised form 21 April 2016; Available online 27 April 2016. Associate editor: Wolf Uwe Reimold. \n\nSEM, EBSD and EPMA analyses were carried out at the Caltech GPS Division Analytical Facility, which is supported, in part, by NSF Grants EAR-0318518 and DMR-0080065. Synchrotron micro-diffraction was carried out at the 16-IDB beamline of the Advanced Photon Source. Use of the Advanced Photon Source, an Office of Science User Facility operated for the U.S. Department of Energy (DOE) Office of Science by Argonne National Laboratory, was supported by the U.S. DOE under Contract No. DE-AC02-06CH11357. OT was sponsored in part by the National Nuclear Security Administration under the Stewardship Science Academic Alliances program through DOE Cooperative Agreement #DE-NA0001982. LAT and JRB acknowledge the support from NASA Cosmochemistry grants NNX11AG58G and NNX12AH63G, respectively. GRR acknowledges the support from NSF grant EAR-1322082. YL acknowledges the support of JPL, which is managed by California Institute of Technology under a contract with NASA. We thank Tom Sharp, Makoto Kimura and an anonymous reviewer for their constructive reviews.\n\nSupplemental Material - mmc1.docx
", "abstract": "Ahrensite (IMA 2013-028), \u03b3-Fe_2SiO_4, is the natural Fe-analog of the silicate-spinel ringwoodite (\u03b3-Mg_2SiO_4). It occurs in the Tissint Martian meteorite, where it forms through the transformation of the fayalite-rich rims of olivine megacrysts or Fe-rich microphenocrysts in contact with shock melt pockets. The typical sequence of phase assemblages traversing across a Tissint melt pocket into olivine is: quenched melt or fayalite-pigeonite intergrowth \u21d2 bridgmanite + w\u00fcstite \u21d2 ahrensite and/or ringwoodite \u21d2 highly-deformed olivine + nanocrystalline ringwoodite \u21d2 deformed olivine. We report the first comprehensive set of crystallographic, spectroscopic, and quantitative chemical analysis of type ahrensite, and show that concentrations of ferric iron and inversion in the type material of this newly approved mineral are negligible. We also report the occurrence of nanocrystalline ringwoodite in strained olivine and establish correlations between grain size and distance from melt pockets. The ahrensite and ringwoodite crystals show no preferred orientation, consistent with random nucleation and incoherent growth within a highly strained matrix of olivine. Grain sizes of ahrensite immediately adjacent to melt pockets are consistent with growth during a shock of moderate duration (1\u201310 ms).", "date": "2016-07-01", "date_type": "published", "publication": "Geochimica et Cosmochimica Acta", "volume": "184", "publisher": "Elsevier", "pagerange": "240-256", "id_number": "CaltechAUTHORS:20160510-133623803", "issn": "0016-7037", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20160510-133623803", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NSF", "grant_number": "EAR-0318518" }, { "agency": "NSF", "grant_number": "DMR-0080065" }, { "agency": "Department of Energy (DOE)", "grant_number": "DEAC02-06CH11357" }, { "agency": "Department of Energy (DOE)", "grant_number": "DE-NA0001982" }, { "agency": "NASA", "grant_number": "NNX11AG58G" }, { "agency": "NASA", "grant_number": "NNX12AH63G" }, { "agency": "NSF", "grant_number": "EAR-1322082" }, { "agency": "NASA/JPL/Caltech" } ] }, "local_group": { "items": [ { "id": "Division-of-Geological-and-Planetary-Sciences" } ] }, "doi": "10.1016/j.gca.2016.04.042", "primary_object": { "basename": "mmc1.docx", "url": "https://authors.library.caltech.edu/records/vvjqz-gqv41/files/mmc1.docx" }, "resource_type": "article", "pub_year": "2016", "author_list": "Ma, Chi; Tschauner, Oliver; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/vt2n0-2fa38", "eprint_id": 71042, "eprint_status": "archive", "datestamp": "2023-08-20 09:47:10", "lastmod": "2023-10-23 15:18:00", "type": "book_section", "metadata_visibility": "show", "creators": { "items": [ { "id": "Luo-Yuan", "name": { "family": "Luo", "given": "Y." } }, { "id": "Zhang-Xiaoxiao", "name": { "family": "Zhang", "given": "Xiaoxiao" } }, { "id": "Packard-R-R-S", "name": { "family": "Packard", "given": "Rene" }, "orcid": "0000-0002-8520-5843" }, { "id": "Rongsong-Li", "name": { "family": "Rongsong", "given": "Li" } }, { "id": "Hsiai-Tzung-K", "name": { "family": "Hsiai", "given": "Tzung K." }, "orcid": "0000-0003-1734-0792" }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Tai-Yu-Chong", "name": { "family": "Tai", "given": "Yu-Chong" }, "orcid": "0000-0001-8529-106X" } ] }, "title": "In-vivo intravascular intervention with parylene micro-electrode to diagnose rupture-prone atherosclerotic plaque using electrical impedance spectroscopy", "ispublished": "unpub", "full_text_status": "restricted", "keywords": "Arteries, Atherosclerosis, Catheters, Electrodes, Impedance, Impedance measurement, Rabbits", "note": "\u00a9 2016 IEEE. \n\nThe author would like to thank all Caltech MEMS group members for their fruitful discussions and suggestions.", "abstract": "It is of great clinical interest to have easy and reliable diagnostic techniques to localize and identify vulnerable plaques. Here, an in-vivo, catheter-integrated and balloon-mounted Parylene-C micro electrode impedance sensor was developed for intra-vascular interrogation of atherosclerotic vulnerable plaques using Electrical Impedance spectroscopy (EIS). Successful in vivo experiments of the EIS device were demonstrated using high-fat-dieted New Zealand rabbits. The results showed that electrical impedance spectroscopy (EIS) with micro parylene electrodes is promising to distinguish unstable plaques.", "date": "2016-01", "date_type": "published", "publisher": "IEEE", "place_of_pub": "Piscataway, NJ", "pagerange": "307-310", "id_number": "CaltechAUTHORS:20161013-093518415", "isbn": "978-1-5090-1973-1", "book_title": "29th International Conference on Micro Electro Mechanical Systems (MEMS), 2016", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20161013-093518415", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "doi": "10.1109/MEMSYS.2016.7421621", "resource_type": "book_section", "pub_year": "2016", "author_list": "Luo, Y.; Zhang, Xiaoxiao; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/3mv62-7yq19", "eprint_id": 71043, "eprint_status": "archive", "datestamp": "2023-08-20 09:47:17", "lastmod": "2023-10-23 15:18:02", "type": "book_section", "metadata_visibility": "show", "creators": { "items": [ { "id": "Shapero-A", "name": { "family": "Shapero", "given": "Aubrey" } }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Tai-Yu-Chong", "name": { "family": "Tai", "given": "Yu-Chong" }, "orcid": "0000-0001-8529-106X" } ] }, "title": "Parylene-on-oil packaging for implantable pressure sensors", "ispublished": "unpub", "full_text_status": "restricted", "keywords": "Decision support systems, Micromechanical devices", "note": "\u00a9 2016 IEEE. \n\nDate Added to IEEE Xplore: 29 February 2016. \n\nThe authors would like to thank Mr. Trevor Roper for his help on all the equipment at the Caltech MEMS Lab.", "abstract": "This paper reports the feasibility study of a parylene-on-oil encapsulation packaging method of pressure sensors targeted for long-term implantation. Commercial barometric digital-output pressure sensors are enclosed in silicone oil and then encapsulated in situ with parylene-C or -D (PA-C, PA-D). Experimentally, sensors encapsulated with 30,000cSt silicone oil and 24.92??m PA-D show good performance for 6 weeks in 77??C saline with >99% of original sensitivity, corresponding to a predicted lifetime of around 21 months in 37??C saline according to the Arrhenius equation with an activation energy of ???0.6eV [1]. This work shows that, with proper designs, such a packaging method can preserve the original pressure sensor sensitivity without offset, validated throughout accelerated lifetime tests. A model to predict sensitivity retention after packaging is also presented.", "date": "2016-01", "date_type": "published", "publisher": "IEEE", "place_of_pub": "Piscataway, NJ", "pagerange": "403-406", "id_number": "CaltechAUTHORS:20161013-101957404", "isbn": "978-1-5090-1973-1", "book_title": "29th International Conference on Micro Electro Mechanical Systems (MEMS), 2016", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20161013-101957404", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "doi": "10.1109/MEMSYS.2016.7421646", "resource_type": "book_section", "pub_year": "2016", "author_list": "Shapero, Aubrey; Liu, Yang; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/ghrkv-cdm55", "eprint_id": 63507, "eprint_status": "archive", "datestamp": "2023-08-20 08:15:37", "lastmod": "2023-10-25 23:52:22", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Xu-Tong", "name": { "family": "Xu", "given": "Tong" } }, { "id": "Xu-Yucheng", "name": { "family": "Xu", "given": "Yucheng" } }, { "id": "Kang-Dongyang", "name": { "family": "Kang", "given": "Dongyang" } }, { "id": "Xu-Lei", "name": { "family": "Xu", "given": "Lei" } }, { "id": "Park-Jungwook", "name": { "family": "Park", "given": "Jungwook" } }, { "id": "Chang-Jay-Han-Chieh", "name": { "family": "Chang", "given": "Jay Han-Chieh" } }, { "id": "Zhang-Xiaoxiao", "name": { "family": "Zhang", "given": "Xiaoxiao" } }, { "id": "Goldkorn-A", "name": { "family": "Goldkorn", "given": "Amir" } }, { "id": "Tai-Yu-Chong", "name": { "family": "Tai", "given": "Yu-Chong" }, "orcid": "0000-0001-8529-106X" } ] }, "title": "Isolation of circulating tumor cells by a magnesium-embedded filter", "ispublished": "pub", "full_text_status": "restricted", "keywords": "circulating tumor cell (CTC), CTC filter, magnesium (Mg), biodegradable", "note": "\u00a9 2015 IOP Publishing Ltd. \n\nReceived 10 March 2015, revised 15 July 2015. Accepted for publication 20 July 2015. Published 21 September 2015. \n\nThe authors gratefully acknowledge the help of all the members of the California Institute of Technology (Caltech) Micromachining Lab, and University of Southern California (USC) Keck School of Medicine Norris Comprehensive Cancer Center, as well as the experimental assistance of Mr Trevor Roper.", "abstract": "Circulating tumor cells (CTCs) are rare cancer cells that are shed by tumors into the bloodstream and that can be valuable biomarkers for various types of cancers. However, CTCs captured on the filter could not be released easily using the existing CTC analysis platforms based on size. To address this limitation, we have developed a novel magnesium (Mg)-embedded cell filter for capture, release and isolation of CTCs. The CTC-filter consists of a thin Ebeam-deposited Mg layer embedded between two parylene-C (PA-C) layers with designed slots for filtration and CTC capture. Thin Mg film has proved highly biocompatible and can be etched in saline, PBS and Dulbecco's modified eagle medium (DMEM) etc, properties that are of great benefit to help dissociate the filter and thus release the cells. The finite element method (FEM) analysis was performed on the Mg etching process in DMEM for the structure design. After the filtration process, the filter was submerged in DMEM to facilitate Mg etching. The top PA-C filter pieces break apart from the bottom after Mg completely dissolves, enabling captured CTCs to detach. The released CTC can be easily aspirated into a micropipette for further analysis. Thus, the Mg-embedded cell filter provides a new and effective approach for CTCs isolation from the filter, making this a promising new strategy for cancer detection.", "date": "2015-09-21", "date_type": "published", "publication": "Journal of Micromechanics and Microengineering", "volume": "25", "number": "10", "publisher": "IOP", "pagerange": "Art. No. 104002", "id_number": "CaltechAUTHORS:20160108-121609556", "issn": "0960-1317", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20160108-121609556", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "doi": "10.1088/0960-1317/25/10/104002", "resource_type": "article", "pub_year": "2015", "author_list": "Liu, Yang; Xu, Tong; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/9frge-8q771", "eprint_id": 59969, "eprint_status": "archive", "datestamp": "2023-08-20 07:29:38", "lastmod": "2023-10-24 14:47:03", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Ma-Chi-Geology", "name": { "family": "Ma", "given": "Chi" }, "orcid": "0000-0002-1828-7033" }, { "id": "Beckett-J-R", "name": { "family": "Beckett", "given": "John" } } ] }, "title": "Hydrothermal Alteration of Martian Zircons in NWA 7034/7533", "ispublished": "pub", "full_text_status": "public", "note": "\u00a9 2015 Meteoritical Society.\n\nPublished - Liu_2015p5080.pdf
", "abstract": "The martian regolith breccia NWA 7034/7533\ncontains abundant zircon grains, which can provide insight into\ncrustal processes through isotopic compositions. For example, insitu\nU-Pb measurements on these zircons suggest a crystallization\nage of ~4.4 Ga with resetting at 1.5-1.7 Ga [1-3]. On the basis of\nintragrain and intergrain oxygen isotope variations, Nemchin et\nal. [4] proposed that zircons crystallized from melts that had assimilated\n^(17)O-enriched regolith, and that the metamict zircons\nwere later altered by low-temperature fluids near the surface at\n~1.7 Ga. Here, we describe the textural context of zircons in\nNWA 7034 and 7533, with an emphasis on those aspects touching\non their hydrothermal alteration.", "date": "2015-08", "date_type": "published", "publication": "Meteoritics and Planetary Science", "volume": "50", "number": "S1", "publisher": "Meteoritical Society", "pagerange": "Art. No. 5080", "id_number": "CaltechAUTHORS:20150828-154254069", "issn": "1086-9379", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20150828-154254069", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "doi": "10.1111/maps.12501", "primary_object": { "basename": "Liu_2015p5080.pdf", "url": "https://authors.library.caltech.edu/records/9frge-8q771/files/Liu_2015p5080.pdf" }, "resource_type": "article", "pub_year": "2015", "author_list": "Liu, Yang; Ma, Chi; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/f9wdx-kds02", "eprint_id": 57226, "eprint_status": "archive", "datestamp": "2023-08-22 15:56:57", "lastmod": "2023-10-23 17:10:54", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Ma-Chi-Geology", "name": { "family": "Ma", "given": "Chi" }, "orcid": "0000-0002-1828-7033" }, { "id": "Tschauner-O", "name": { "family": "Tschauner", "given": "Oliver" }, "orcid": "0000-0003-3364-8906" }, { "id": "Beckett-J-R", "name": { "family": "Beckett", "given": "John R." } }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Rossman-G-R", "name": { "family": "Rossman", "given": "George R." }, "orcid": "0000-0002-4571-6884" }, { "id": "Zuravlev-K-K", "name": { "family": "Zhuravlev", "given": "Kirill" } }, { "id": "Prakapenka-V-B", "name": { "family": "Prakapenka", "given": "Vitali" }, "orcid": "0000-0001-9270-2330" }, { "id": "Dera-P", "name": { "family": "Dera", "given": "Przemyslaw" } }, { "id": "Taylor-L-A", "name": { "family": "Taylor", "given": "Lawrence A." } } ] }, "title": "Tissintite, (Ca,Na,\u25a1)AlSi_2O_6, a highly-defective, shock-induced, high-pressure clinopyroxene in the Tissint martian meteorite", "ispublished": "pub", "full_text_status": "restricted", "keywords": "tissintite; (CaNa\u25a1)AlSi2O6; new high-pressure pyroxene; Ca-Eskola; Tissint martian shergottite; synchrotron diffraction", "note": "\u00a9 2015 Elsevier B.V. Received 13 June 2014, Revised 30 March 2015, Accepted 31 March 2015, Available online 24 April 2015.\nEditor: J. Brodholt. \n\nSEM, EBSD and EPMA analyses were carried out at the Caltech GPS Division Analytical Facility, which is supported, in part, by NSF Grants EAR-0318518 and DMR-0080065. Synchrotron diffraction was carried out at the 13-IDD beamline of the Advanced Photon Source and the 12.2.2 beamline of the Advanced Light Source. Use of the Advanced Photon Source, an Office of Science User Facility operated for the U.S. Department of Energy (DOE) Office of Science by Argonne National Laboratory, was supported by the U.S. DOE under Contract No. DE-AC02-06CH11357. The Advanced Light Source is supported by the Director, Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. OT acknowledges the support from DOE Cooperative Agreement #DE-NA0001982. GRR acknowledges NSF EAR grant 322082. LAT and JRB acknowledge NASA Cosmo-chemistry grants NNX11AG58G and NNX12AH63G, respectively. PD gratefully acknowledges support from NSF grants EAR 1344942 and 1440005. Formal reviews by A. El Goresy and an anonymous re-viewer and additional comments by T. Kubo all led to significant improvements.", "abstract": "Tissintite is a new vacancy-rich, high-pressure clinopyroxene, with a composition essentially equivalent to plagioclase. It was discovered in maskelynite (shocked plagioclase) and is commonly observed included within, or in contact with, shock-melt pockets in the Tissint meteorite, a depleted olivine-phyric shergottite fall from Mars. The simple composition of tissintite (An58\u201369) and its precursor plagioclase (An59\u201369) together with the limited occurrence, both spatially (only in maskelynite less than \u223c25 \u03bcm of a shock melt pocket) and in terms of bulk composition, make tissintite a \"goldilocks\" phase. It formed during a shock event severe enough to allow nucleation and growth of vacancy-rich clinopyroxene from a melt of not too calcic and not too sodic plagioclase composition that was neither too hot nor too cold. With experimental calibration, these limitations on occurrence can be used to place strong constraints on the thermal history of a shock event. The kinetics for nucleation and growth of tissintite are probably slower for more-sodic plagioclase precursors, so tissintite is most likely to occur in depleted olivine-phyric shergottites like Tissint and other highly shocked meteorites and lunar and terrestrial rocks that consistently contained calcic plagioclase precursors in the appropriate compositional range for a shock of given intensity.\n\nTissintite, (Ca_(0.45)Na_(0.31)\u25a1_(0.24))(Al_(0.97)Fe_(0.03)Mg_(0.01))(Si_(1.80)Al_(0.20))O6, is a C2/c clinopyroxene, containing 42\u201360 mol% of the Ca-Eskola component, by far the highest known. The cell parameters are \u0251=9.21(17) \u00c5, b=9.09(4) \u00c5, c=5.20(2) \u00c5, \u03b2=109.6(9)\u00b0, V=410(8) \u00c5^3, Z=4Z=4. The density is 3.32 g/cm^3 and we estimate a cell volume for the Ca-Eskola end-member pyroxene of 411\u00b113 \u00c5^3, which is consistent with a previous estimate and, therefore, supports the importance of this component in clinopyroxenes from ultra-high pressure metamorphic rocks from the Earth's upper mantle. At least in C2/c clinopyroxenes as sodic as tissintite, the a- and b-cell parameters as a function of vacancy concentration intersect at \u223c0.3 vacancies pfu, much lower than the Ca-Eskola end-member (0.5), an inversion of anisotropy suggesting an elastic instability that drives clinopyroxene toward a disordered trigonal structure closely related to that of wadeite; it may mark the boundary beyond which the breakdown of vacancy-rich clinopyroxene to a wadeite-structured phase + stishovite becomes stable, although this was not observed in Tissint.", "date": "2015-07-15", "date_type": "published", "publication": "Earth and Planetary Science Letters", "volume": "422", "publisher": "Elsevier", "pagerange": "194-205", "id_number": "CaltechAUTHORS:20150505-101702971", "issn": "0012-821X", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20150505-101702971", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NSF", "grant_number": "EAR-0318518" }, { "agency": "NSF", "grant_number": "DMR-0080065" }, { "agency": "Department of Energy (DOE)", "grant_number": "DE-AC02-06CH11357" }, { "agency": "Department of Energy (DOE)", "grant_number": "DE-AC02-05CH11231" }, { "agency": "Department of Energy (DOE)", "grant_number": "DE-NA0001982" }, { "agency": "NSF", "grant_number": "EAR 322082" }, { "agency": "NASA", "grant_number": "NNX11AG58G" }, { "agency": "NASA", "grant_number": "NNX12AH63G" }, { "agency": "NSF", "grant_number": "EAR 1344942" }, { "agency": "NSF", "grant_number": "EAR 1440005" } ] }, "local_group": { "items": [ { "id": "Division-of-Geological-and-Planetary-Sciences" } ] }, "doi": "10.1016/j.epsl.2015.03.057", "resource_type": "article", "pub_year": "2015", "author_list": "Ma, Chi; Tschauner, Oliver; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/vhek2-ccb04", "eprint_id": 69954, "eprint_status": "archive", "datestamp": "2023-09-15 05:30:57", "lastmod": "2023-10-23 21:18:32", "type": "book_section", "metadata_visibility": "show", "creators": { "items": [ { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Y." } }, { "id": "Shapero-Aubrey", "name": { "family": "Shapero", "given": "A." }, "orcid": "0000-0002-8036-3623" }, { "id": "Zhang-Xiaoxiao", "name": { "family": "Zhang", "given": "X." } }, { "id": "Kang-Dongyang", "name": { "family": "Kang", "given": "D." } }, { "id": "Park-Jae-Koo", "name": { "family": "Park", "given": "J." } }, { "id": "Xu-Lei", "name": { "family": "Xu", "given": "L." } }, { "id": "Chang-Kai-Tang", "name": { "family": "Chang", "given": "K." } }, { "id": "Lin-Huangda", "name": { "family": "Lin", "given": "H." } }, { "id": "Ferreri-K", "name": { "family": "Ferreri", "given": "K." } }, { "id": "Tai-Yu-Chong", "name": { "family": "Tai", "given": "Y. C." }, "orcid": "0000-0001-8529-106X" } ] }, "title": "MEMS for single-islet electroisletogram", "ispublished": "unpub", "full_text_status": "restricted", "keywords": "Islet, diabetes, multielectrode arrays (MEAs), electroisletogram (EIG)", "note": "\u00a9 2015 IEEE. \n\nThe authors would greatly thank all the members of California Institute of Technology (Caltech) MEMS lab, especially Mr. Trevor Roper for the maintenance of equipment.", "abstract": "This paper reports the first MEMS device designed for in vitro measuring of electroisletogram (EIG) of individual rat islets. Using vacuum to hold an islet in proximity to a microelectrode, strong EIG signals in millivolt range are obtained, while the noise is about 100\u03bcV pk-pk. This work proves the feasibility of using MEMS and EIG for high-throughput screening, in contrast to patch-clamp measurements, of islets for transplantation to treat diabetes.", "date": "2015-06", "date_type": "published", "publisher": "IEEE", "place_of_pub": "Piscataway, NJ", "pagerange": "77-80", "id_number": "CaltechAUTHORS:20160826-090759324", "isbn": "978-1-4799-8955-3", "book_title": "18th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS)", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20160826-090759324", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "doi": "10.1109/TRANSDUCERS.2015.7180865", "resource_type": "book_section", "pub_year": "2015", "author_list": "Liu, Y.; Shapero, A.; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/72t28-3q705", "eprint_id": 58976, "eprint_status": "archive", "datestamp": "2023-08-20 05:39:25", "lastmod": "2023-10-23 19:56:41", "type": "book_section", "metadata_visibility": "show", "creators": { "items": [ { "id": "Zhang-Xiaoxiao", "name": { "family": "Zhang", "given": "Xiaoxiao" } }, { "id": "Xu-Lei", "name": { "family": "Xu", "given": "Lei" } }, { "id": "Lee-Juhyun", "name": { "family": "Lee", "given": "Juhyun" } }, { "id": "Li-Rongsong", "name": { "family": "Li", "given": "Rongsong" } }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Shapero-A-M", "name": { "family": "Shapero", "given": "Aubrey" } }, { "id": "Hsiai-Tzung-K", "name": { "family": "Hsiai", "given": "Tzung K." }, "orcid": "0000-0003-1734-0792" }, { "id": "Tai-Yu-Chong", "name": { "family": "Tai", "given": "Yu-Chong" }, "orcid": "0000-0001-8529-106X" } ] }, "title": "Flexible micro sensor for intravascular vulnerable plaque diagnostic with electrical impedance spectroscopy", "ispublished": "unpub", "full_text_status": "restricted", "note": "\u00a9 2015 IEEE.", "abstract": "Studies have shown emerging evidence that rupture of coronary plaque containing a lipid-rich core with subsequent thrombus formation is the most frequent mechanism by which atherosclerosis leads to the acute ischaemic syndromes of unstable angina, acute myocardial infarction, and often times, sudden cardiac death. However, since the lumen is not significantly blocked in these cases, such \"vulnerable\" plaques show noncritical stenosis in X-ray angiography and Intravascular Ultrasound (IVUS), tools currently available to diagnose coronary artery disease. The ability to distinguish such rupture-prone vulnerable plaques remains largely lacking. Therefore it is of great clinical interest to find improved diagnostic techniques to identify and localize such rupture-prone plaques. On the other hand, lipid has significantly lower electrical impedance than the rest of the vessel components in certain frequency bands [1]. We show in this paper that electrical impedance spectroscopy (EIS) technique can be useful to effectively distinguish plaques with such lipid cores. We include in this paper the design rationale of a four electrode EIS sensor and the measurement results between 1 Hz to 300 KHz of ex-vivo mouse aortas with plaque lesions. The impedance modulus over 200 Hz-100 KHz show consistent elevated values 2-5 times higher than their proximity control sites in all three individual mice. The promising ex-vivo EIS results show promising potential for a reliable unstable plaque diagnostic tool for in-vivo catheter integrated intravascular micro EIS sensors.", "date": "2015-04", "date_type": "published", "publisher": "IEEE", "id_number": "CaltechAUTHORS:20150722-080523739", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20150722-080523739", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "doi": "10.1109/NEMS.2015.7147419", "resource_type": "book_section", "pub_year": "2015", "author_list": "Zhang, Xiaoxiao; Xu, Lei; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/792jg-d9b91", "eprint_id": 65452, "eprint_status": "archive", "datestamp": "2023-08-20 04:27:46", "lastmod": "2023-10-18 16:01:53", "type": "book_section", "metadata_visibility": "show", "creators": { "items": [ { "id": "Kang-Dongyang", "name": { "family": "Kang", "given": "Dongyang" } }, { "id": "Murali-K", "name": { "family": "Murali", "given": "Karthik" } }, { "id": "Scianmarello-N", "name": { "family": "Scianmarello", "given": "Nicholas" } }, { "id": "Park-Jungwook", "name": { "family": "Park", "given": "Jungwook" } }, { "id": "Chang-Jay-Han-Chieh", "name": { "family": "Chang", "given": "Jay Han-Chieh" } }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Chang-Kai-Tang", "name": { "family": "Chang", "given": "Kai-Tang" } }, { "id": "Tai-Yu-Chong", "name": { "family": "Tai", "given": "Yu-Chong" }, "orcid": "0000-0001-8529-106X" }, { "id": "Humayun-M-S", "name": { "family": "Humayun", "given": "Mark S." }, "orcid": "0000-0002-5830-5208" } ] }, "title": "MEMS oxygen transporter to treat retinal ischemia", "ispublished": "unpub", "full_text_status": "restricted", "note": "\u00a9 2015 IEEE. \n\nThis work is funded by National Institute of Health. The authors gratefully acknowledge the help of all the members from the Caltech Micromachining Lab and the USC Eye Institute.", "abstract": "For the first time, a paradigm shift in the treatment of retinal ischemia is proposed: providing localized supplemental oxygen to the ischemic tissue via an implanted MEMS device. A passive MEMS oxygen transporter is designed, built and tested in both artificial eye models and porcine cadaver eyes to confirm various hypotheses. The finite element modeling results predict that the proposed approach can treat complete retinal ischemia.", "date": "2015-01", "date_type": "published", "publisher": "IEEE", "place_of_pub": "Piscataway, NJ", "pagerange": "154-157", "id_number": "CaltechAUTHORS:20160317-142016193", "isbn": "978-1-4799-7955-4", "book_title": "28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2015)", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20160317-142016193", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NIH" } ] }, "doi": "10.1109/MEMSYS.2015.7050909", "resource_type": "book_section", "pub_year": "2015", "author_list": "Kang, Dongyang; Murali, Karthik; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/6mhw0-0ye36", "eprint_id": 65453, "eprint_status": "archive", "datestamp": "2023-08-20 04:27:53", "lastmod": "2023-10-18 16:02:00", "type": "book_section", "metadata_visibility": "show", "creators": { "items": [ { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Park-Jungwook", "name": { "family": "Park", "given": "Jungwook" } }, { "id": "Xu-Tong", "name": { "family": "Xu", "given": "Tong" } }, { "id": "Chang-Jay-Han-Chieh", "name": { "family": "Chang", "given": "Jay Han-Chieh" } }, { "id": "Kang-Dongyang", "name": { "family": "Kang", "given": "Dongyang" } }, { "id": "Zhang-Xiaoxiao", "name": { "family": "Zhang", "given": "Xiaoxiao" } }, { "id": "Goldkorn-A", "name": { "family": "Goldkorn", "given": "Amir" } }, { "id": "Tai-Yu-Chong", "name": { "family": "Tai", "given": "Yu-Chong" }, "orcid": "0000-0001-8529-106X" } ] }, "title": "Magnesium-embedded live cell filter for CTC isolation", "ispublished": "unpub", "full_text_status": "restricted", "note": "\u00a9 2015 IEEE. \n\nThe authors gratefully acknowledge the help of all the members in California Institute of Technology (Caltech) Micromachining Lab, and University of Southern California (USC) Keck School of Medicine Norris Comprehensive Cancer Center, as well as experimental assistance of Mr. Trevor Roper.", "abstract": "This paper reports a novel Magnesium-embedded cell filter for Circulating Tumor Cell (CTC) capture, release and isolation. The new and novel feature is the use of thin-film Mg to release the captured CTCs based on the fact that any Cl^- containing culture medium can readily etch Mg away [1]. The releasing and the isolation of each individual CTC are demonstrated here. After filtration process, the filter is submerged in PBS to facilitate Mg etching. The top PA-C filter pieces break apart from the bottom after Mg completely dissolves, enabling captured CTC cells to detach from the filter. The released CTC can then be easily aspirated into a micropipette, and then for further, such as, DNA mutation analysis.", "date": "2015-01", "date_type": "published", "publisher": "IEEE", "place_of_pub": "Piscataway, NJ", "pagerange": "340-343", "id_number": "CaltechAUTHORS:20160317-142858089", "isbn": "978-1-4799-7955-4", "book_title": "28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2015)", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20160317-142858089", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "doi": "10.1109/MEMSYS.2015.7050958", "resource_type": "book_section", "pub_year": "2015", "author_list": "Liu, Yang; Park, Jungwook; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/q64ax-k0w63", "eprint_id": 65456, "eprint_status": "archive", "datestamp": "2023-08-20 04:28:07", "lastmod": "2023-10-18 16:02:20", "type": "book_section", "metadata_visibility": "show", "creators": { "items": [ { "id": "Zhang-Xiaoxiao", "name": { "family": "Zhang", "given": "Xiaoxiao" } }, { "id": "Beebe-T", "name": { "family": "Beebe", "given": "Tyler" } }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Park-Jungwook", "name": { "family": "Park", "given": "Jungwook" } }, { "id": "Hsiai-Tzung-K", "name": { "family": "Hsiai", "given": "Tzung K." }, "orcid": "0000-0003-1734-0792" }, { "id": "Tai-Yu-Chong", "name": { "family": "Tai", "given": "Yu-Chong" }, "orcid": "0000-0001-8529-106X" } ] }, "title": "Wearable flexible micro electrode for adult zebrafish long term ecgmonitoring", "ispublished": "unpub", "full_text_status": "restricted", "note": "\u00a9 2015 IEEE. \n\nThis work is partially funded by the NIH, grant number R01 HL111437. The author would like to thank all Caltech MEMS group members for their fruitful discussions and suggestions.", "abstract": "During the last decade, close resemblance between the zebrafish heart and human heart physiology has been discovered [1] andzebrafish (Danio rerio) has become an emerging animal model for studying side effects developmental drugs may impose on the heart [2][3]. More interestingly, contrary to human heart the zebrafish heart has a remarkable ability to \"regenerate\" after severe injury [4], making it also a popular model for studies of regenerative medicine. On the other hand, Electrocardiogram (ECG) is a widely used tool to monitor the physiological changes of the zebrafish heart. However, due to its in-water habitat, a long term ECG monitoring solution, although very much needed, was not present. All published adult zebrafish ECG recorded to this date have been done acutely with anesthetized fish. This work presents, for the first time a wearable flexible parylene (PA) micro-electrode that monitors the Adult Zebrafish ECG long term. We show here the design, fabrication and testing of the flexible electrode along with a micro-molded ultra-soft, density adjusted silicone jacket, allowing ECG recording to be carried under water, in the fish's natural habitat with no need for anesthesia.", "date": "2015-01", "date_type": "published", "publisher": "IEEE", "place_of_pub": "Piscataway, NJ", "pagerange": "690-693", "id_number": "CaltechAUTHORS:20160317-144512824", "isbn": "978-1-4799-7955-4", "book_title": "28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2015)", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20160317-144512824", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NIH", "grant_number": "R01 HL111437" } ] }, "doi": "10.1109/MEMSYS.2015.7051051", "resource_type": "book_section", "pub_year": "2015", "author_list": "Zhang, Xiaoxiao; Beebe, Tyler; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/epa1y-pwd58", "eprint_id": 93298, "eprint_status": "archive", "datestamp": "2023-08-20 00:27:41", "lastmod": "2023-10-20 17:01:01", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Yuan-Hsiangkuo", "name": { "family": "Yuan", "given": "Hsiangkuo" } }, { "id": "Wilson-C-M", "name": { "family": "Wilson", "given": "Christy M." } }, { "id": "Xia-Jun", "name": { "family": "Xia", "given": "Jun" } }, { "id": "Doyle-S-L", "name": { "family": "Doyle", "given": "Sarah L." } }, { "id": "Li-Shuqin", "name": { "family": "Li", "given": "Shuqin" } }, { "id": "Fales-A-M", "name": { "family": "Fales", "given": "Andrew M." } }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Ozaki-E", "name": { "family": "Ozaki", "given": "Ema" } }, { "id": "Mulfaul-K", "name": { "family": "Mulfaul", "given": "Kelly" } }, { "id": "Hanna-G", "name": { "family": "Hanna", "given": "Gabi" } }, { "id": "Palmer-G-M", "name": { "family": "Palmer", "given": "Gregory M." } }, { "id": "Wang-Lihong-V", "name": { "family": "Wang", "given": "Lihong V." }, "orcid": "0000-0001-9783-4383" }, { "id": "Grant-G-A", "name": { "family": "Grant", "given": "Gerald A." } }, { "id": "Vo-Dinh-Tuan", "name": { "family": "Vo-Dinh", "given": "Tuan" } } ] }, "title": "Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor", "ispublished": "pub", "full_text_status": "public", "note": "\u00a9 2014 The Royal Society of Chemistry.\n\nThe article was received on 21 Dec 2013, accepted on 26 Feb 2014 and first published on 04 Mar 2014.\n\nThis work was supported in part from the National Institutes of Health (Grant R01 EB006201, T32 EB001040, 5K08-NS075144-03, DP1 EB016986, R01 EB016963), the Department of Defense (DOD Award W81XWH-09-1-0064), the Defense Advanced Research Projects Agency (HR0011-13-2-0003), the Duke Exploratory Research Funds, and National Children's Research Centre (NCRC) Funds. The content of the information does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. The authors would like to thank Dr Darell Bigner and the Duke Preston Robert Tisch Brain Tumor Center for their support of the human brain tumor xenografts used in the orthotopic mouse models, as well as Dr Sam Johnson and the Duke Light Microscopy Core Facility for their expertise in multiphoton microscopy.\n\nPublished - c3nr06770j.pdf
Accepted Version - nihms581535.pdf
Supplemental Material - c3nr06770j1_si.pdf
", "abstract": "Plasmonics-active gold nanostars exhibiting strong imaging contrast and efficient photothermal transduction were synthesized for a novel pulsed laser-modulated plasmonics-enhanced brain tumor microvascular permeabilization. We demonstrate a selective, optically modulated delivery of nanoprobes into the tumor parenchyma with minimal off-target distribution.", "date": "2014-04-21", "date_type": "published", "publication": "Nanoscale", "volume": "6", "number": "8", "publisher": "Royal Society of Chemistry", "pagerange": "4078-4082", "id_number": "CaltechAUTHORS:20190227-104319278", "issn": "2040-3364", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20190227-104319278", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NIH", "grant_number": "R01 EB006201" }, { "agency": "NIH Predoctoral Fellowship", "grant_number": "T32 EB001040" }, { "agency": "NIH", "grant_number": "5K08-NS075144-03" }, { "agency": "NIH", "grant_number": "DP1 EB016986" }, { "agency": "NIH", "grant_number": "R01 EB016963" }, { "agency": "Department of Defense", "grant_number": "W81XWH-09-1-0064" }, { "agency": "Defense Advanced Research Projects Agency (DARPA)", "grant_number": "HR0011-13-2-0003" }, { "agency": "Duke University" }, { "agency": "National Children's Research Centre" } ] }, "doi": "10.1039/c3nr06770j", "pmcid": "PMC4343032", "primary_object": { "basename": "c3nr06770j.pdf", "url": "https://authors.library.caltech.edu/records/epa1y-pwd58/files/c3nr06770j.pdf" }, "related_objects": [ { "basename": "c3nr06770j1_si.pdf", "url": "https://authors.library.caltech.edu/records/epa1y-pwd58/files/c3nr06770j1_si.pdf" }, { "basename": "nihms581535.pdf", "url": "https://authors.library.caltech.edu/records/epa1y-pwd58/files/nihms581535.pdf" } ], "resource_type": "article", "pub_year": "2014", "author_list": "Yuan, Hsiangkuo; Wilson, Christy M.; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/5t60r-77v44", "eprint_id": 50139, "eprint_status": "archive", "datestamp": "2023-08-19 22:57:09", "lastmod": "2023-10-17 22:32:38", "type": "book_section", "metadata_visibility": "show", "creators": { "items": [ { "id": "Chang-Jay-Han-Chieh", "name": { "family": "Chang", "given": "Jay Han-Chieh" } }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Tai-Yu-Chong", "name": { "family": "Tai", "given": "Yu-Chong" }, "orcid": "0000-0001-8529-106X" } ] }, "title": "Long term glass-encapsulated packaging for implant electronics", "ispublished": "unpub", "full_text_status": "restricted", "note": "\u00a9 2014 IEEE. This work is supported by the NSF ERC center of\nBiomimetic MicroElectronic Systems (BMES). The authors\nwould like to thank Mr. Trevor Roper for assistance with\nfabrication and equipment maintenance, and other group\nmembers of the Caltech Micromachining Laboratory for the\nfruitful discussions.", "abstract": "Hermetic Titanium-alloy packaging (e.g., used in pacemakers and cochlear implants) has been accepted as the industrial standard for decades. However, two remaining issues of this well-known technology are the size and limited number of feedthroughs [1]. On the other hand, the next generation wireless intraocular retinal prosthetic devices do require unprecedented small size and large number of leads to be fitted inside a human eyeball so the traditional metal packaging is difficult to be implemented. Therefore, these new generation of microimplants will need a new packaging scheme. This paper then reports a new long-term packaging method using glass encapsulation featuring a controlled failure mode from fast diffusion to slow undercut. The results is promising that this new packaging scheme could survive more than 10 years by accelerated \"active\" lifetime soaking test (i.e., with electric field applied) in 0.9 wt.% saline solution. As a whole, this new method provides several advantages including easy employment, controllable long life time, and enhanced heat dissipation.", "date": "2014-01", "date_type": "published", "publisher": "IEEE", "place_of_pub": "Piscataway, NJ", "pagerange": "1127-1130", "id_number": "CaltechAUTHORS:20141001-100142033", "isbn": "978-1-4799-3508-6", "book_title": "IEEE 27th International Conference on Micro Electro Mechanical Systems (MEMS), 2014", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20141001-100142033", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NSF" } ] }, "doi": "10.1109/MEMSYS.2014.6765844", "resource_type": "book_section", "pub_year": "2014", "author_list": "Chang, Jay Han-Chieh; Liu, Yang; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/8v3az-p7h55", "eprint_id": 50118, "eprint_status": "archive", "datestamp": "2023-08-19 22:56:53", "lastmod": "2023-10-17 22:31:48", "type": "book_section", "metadata_visibility": "show", "creators": { "items": [ { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Park-Jungwook", "name": { "family": "Park", "given": "Jungwook" } }, { "id": "Chang-Jay-Han-Chieh", "name": { "family": "Chang", "given": "Jay Han-Chieh" } }, { "id": "Tai-Yu-Chong", "name": { "family": "Tai", "given": "Yu-Chong" }, "orcid": "0000-0001-8529-106X" } ] }, "title": "Thin-film magnesium as a sacrificial and biodegradable material", "ispublished": "unpub", "full_text_status": "restricted", "note": "\u00a9 2014 IEEE.\n\nThe authors gratefully acknowledge the help of all the\nmembers in California Institute of Technology (Caltech)\nMicromachining Lab and experimental assistance of Mr.\nTrevor Roper. We also specially thank Mrs. Boyu Li and\nMrs. Jionghui Li for their discussion.", "abstract": "This work reports the study of ebeam-deposited\nthin-film magnesium (Mg) as a sacrificial and a\nbiodegradable material. We have tested etchants including\ndiluted hydrochloric acid (HCl), saline, and culture medium.\nBoth vertical etching method and channel undercut method\nare used to characterize the Mg etching properties. The initial results confirm that thin-film Mg is a promising dual sacrificial and biodegradable material. In addition, an etching model, which fits accurately the etching length vs. time over a wide range of HCl concentrations (0.02-1M) is developed. This model is based on diffusion and a combined first-and-second order chemical reaction mechanism.", "date": "2014-01", "date_type": "published", "publisher": "IEEE", "id_number": "CaltechAUTHORS:20140930-095858887", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20140930-095858887", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "doi": "10.1109/MEMSYS.2014.6765726", "resource_type": "book_section", "pub_year": "2014", "author_list": "Liu, Yang; Park, Jungwook; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/p07jd-9w493", "eprint_id": 45853, "eprint_status": "archive", "datestamp": "2023-08-19 20:15:06", "lastmod": "2023-10-26 18:29:59", "type": "book_section", "metadata_visibility": "show", "creators": { "items": [ { "id": "Chang-Jay-Han-Chieh", "name": { "family": "Chang", "given": "Jay Han-Chieh" } }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Tai-Yu-Chong", "name": { "family": "Tai", "given": "Yu-Chong" }, "orcid": "0000-0001-8529-106X" } ] }, "title": "A low-temperature parylene-C-to-silicon bonding using photo-patternable adhesives and its applications", "ispublished": "unpub", "full_text_status": "restricted", "keywords": "Parylene-C, Photo-patternable adhesive, BioMEMS, Retinal implant", "note": "\u00a9 2013 IEEE. This work is supported by the NSF BMES ERC center. The author would like to thank Mr. Trevor Roger for his help on all the equipments and all Caltech MEMS group members for their fruitful discussions and suggestions. The author would also like to thank Dr. WenTai Liu for providing 268-channel retinal IC chips.", "abstract": "Parylene-C has become a more and more popular material for BioMEMS implant applications due to its good biomedical properties [1, 2]. It was also used as an intermediate layer for silicon wafer bonding [3, 4]. However, the bonding between parylene-C and silicon is still problematic. In this paper, a low-temperature bonding between parylene-C and silicon using photo-patternable adhesives is presented. This method can not only determine the bonding pads but also reduce the residual stress in the packaging. Its application on high-density multi-channel chip integration is also demonstrated. Two commercially available photo-patternable materials, i.e., SU-8 and AZ-4620, with stable characteristics are chosen to demonstrate this method. The processing conditions are optimized in terms of bonding temperature, pressure, time, and surface treatment. The peeling force is measured by ASTM peeling tests under various bonding conditions. The results show that the epoxy-based SU-8 is better than AZ-4620 as an adhesive material with a peeling force up to 8.4 N/cm^2. This low-temperature bonding technique allows selectively local area bonding. Besides, bonding without applying a high electric field is especially suitable for the integration with microelectronics in MEMS packaging.", "date": "2013-06", "date_type": "published", "publisher": "IEEE", "place_of_pub": "Piscataway, NJ", "pagerange": "2217-2220", "id_number": "CaltechAUTHORS:20140520-142317006", "isbn": "9781467359818", "book_title": "2013 Transducers & Eurosensors XXVII", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20140520-142317006", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NSF" } ] }, "doi": "10.1109/Transducers.2013.6627244", "resource_type": "book_section", "pub_year": "2013", "author_list": "Chang, Jay Han-Chieh; Liu, Yang; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/emdt5-kcg02", "eprint_id": 45852, "eprint_status": "archive", "datestamp": "2023-08-19 20:14:59", "lastmod": "2023-10-26 18:29:55", "type": "book_section", "metadata_visibility": "show", "creators": { "items": [ { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Park-Jungwook", "name": { "family": "Park", "given": "Jungwook" } }, { "id": "Lang-R-J", "name": { "family": "Lang", "given": "Robert J." } }, { "id": "Emami-A", "name": { "family": "Emami-Neyestanak", "given": "Azita" }, "orcid": "0000-0002-6945-9958" }, { "id": "Pellegrino-S", "name": { "family": "Pellegrino", "given": "Sergio" }, "orcid": "0000-0001-9373-3278" }, { "id": "Humayun-M-S", "name": { "family": "Humayun", "given": "Mark S." }, "orcid": "0000-0002-5830-5208" }, { "id": "Tai-Yu-Chong", "name": { "family": "Tai", "given": "Yu-Chong" }, "orcid": "0000-0001-8529-106X" } ] }, "title": "Parylene origami structure for intraocular implantation", "ispublished": "unpub", "full_text_status": "restricted", "keywords": "Origami, parylene-C, intraocular implantation", "note": "\u00a9 2013 IEEE. The authors would like to thank all the group members in the Caltech MEMS and Micromachining lab for help and discussion. We thank Mr. Trevor Roper especially for his guidance and maintenance on equipment in the lab. We also thank Lee L. Wilson from Dr. Sergio's group and Matthew Loh from Dr. Azita's group.", "abstract": "This paper presents the use of origami technique to construct a 3D spherical structure from a 2D parylene-C (PA-C) film with designed folding crease patterns. This origami technique is developed or intended for intraocular epiretinal implant application, which requires a \"curved\" electrode array to match the curvature of the macula. The folding method and process are described here using silicone oil as a temporary glue to hold the folded structures through meniscus force. The temporary origami is then thermally set into permanent 3D shapes at 100 \u00b0C for 30 minutes in vacuum utilizing parylene-C's viscoelastic properties. The reported origami technique enables the possibility of first making an extended device in 2D format and, after a possible minimal surgical cut and insertion, then folding it into a 3D device inside the eye for necessary geometric matching with host tissues.", "date": "2013-06", "date_type": "published", "publisher": "IEEE", "place_of_pub": "Piscataway, NJ", "pagerange": "1549-1552", "id_number": "CaltechAUTHORS:20140520-140334969", "isbn": "9781467359818", "book_title": "2013 Transducers & Eurosensors XXVII", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20140520-140334969", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "local_group": { "items": [ { "id": "GALCIT" } ] }, "doi": "10.1109/Transducers.2013.6627077", "resource_type": "book_section", "pub_year": "2013", "author_list": "Liu, Yang; Park, Jungwook; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/pwgmn-g2v34", "eprint_id": 45850, "eprint_status": "archive", "datestamp": "2023-08-19 20:14:51", "lastmod": "2023-10-26 18:29:49", "type": "book_section", "metadata_visibility": "show", "creators": { "items": [ { "id": "Chang-Jay-Han-Chieh", "name": { "family": "Chang", "given": "Jay Han-Chieh" } }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Kang-Dongyang", "name": { "family": "Kang", "given": "Dongyang" } }, { "id": "Tai-Yu-Chong", "name": { "family": "Tai", "given": "Yu-Chong" }, "orcid": "0000-0001-8529-106X" } ] }, "title": "Reliable packaging for parylene-based flexible retinal implant", "ispublished": "unpub", "full_text_status": "restricted", "keywords": "Packaging, Parylene, MEMS, Lifetime", "note": "\u00a9 2013 IEEE. This work is supported by NSF BMES ERC center. The author would like to thank Mr. Trevor Roper for his help on all the equipments and all Caltech MEMS group members for their fruitful discussions and suggestions.", "abstract": "MEMS technology has been used more and more in biomedical application for neural prosthetic implantation [1, 2]. These devices, however, will have to endure harsh and corrosive body fluids [3]. Therefore, biostable and hermetic-like packaging is needed to protect the implant. This work reports the package reliability of parylene-based retinal implant using active (i.e., with electrical signals applied) and accelerated lifetime soaking test in saline. Commercial amplifier chips, dummy conduction chips, and discrete components are tested and the failure modes are examined. It is found that the proposed parylene-metal-parylene flexible composite sandwich layers indeed have longer lifetime than traditional inflexible silicone-parylene combination. In addition, the chip size effect on lifetime is observed that smaller chips have longer lifetime under the same protection.", "date": "2013-06", "date_type": "published", "publisher": "IEEE", "place_of_pub": "Piscataway, NJ", "pagerange": "2612-2615", "id_number": "CaltechAUTHORS:20140520-115123627", "isbn": "9781467359818", "book_title": "2013 Transducers & Eurosensors XXVII", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20140520-115123627", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NSF" } ] }, "doi": "10.1109/Transducers.2013.6627341", "resource_type": "book_section", "pub_year": "2013", "author_list": "Chang, Jay Han-Chieh; Liu, Yang; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/y3nf0-ed429", "eprint_id": 39616, "eprint_status": "archive", "datestamp": "2023-08-19 14:13:47", "lastmod": "2023-10-24 16:59:56", "type": "book_section", "metadata_visibility": "show", "creators": { "items": [ { "id": "Kang-Dongyang", "name": { "family": "Kang", "given": "Dongyang" } }, { "id": "Standley-A", "name": { "family": "Standley", "given": "Andrew" } }, { "id": "Chang-Jay-Han-Chieh", "name": { "family": "Chang", "given": "Jay Han-Chieh" } }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Tai-Yu-Chong", "name": { "family": "Tai", "given": "Yu-Chong" }, "orcid": "0000-0001-8529-106X" } ] }, "title": "Effects of deposition temperature on Parylene-C properties", "ispublished": "unpub", "full_text_status": "restricted", "note": "\u00a9 2013 IEEE.\n\nThe authors would like to thank all the colleagues\nworking in the Caltech Micromaching Laboratory for\ntheir generous help in the sample preparation and\ndiscussion of the experiments.", "abstract": "This paper reports the study of in-situ deposition temperature (ranging from 20\u00b0C to 80\u00b0C) effects on Parylene-C properties in terms of glass transition temperature (T_g), \u03b2-relaxation temperature (T_\u03b2), Young's modulus and crystallinity (including crystallite size). The results show that the Parylene-C (PA-C) thin film deposited at higher deposition temperature exhibits higher T_g and T_\u03b2, revealing that the movement of the molecular backbones is further frozen and restricted. It is physically consistent with the data showing that higher deposition temperature induces greater degree of crystallinity and larger Young's modulus. With the new knowledge, Parylene-C thin film with properties tailored to various requirements could be achieved by choosing the proper deposition temperature.", "date": "2013-01", "date_type": "published", "publisher": "IEEE", "place_of_pub": "Piscataway, NJ", "pagerange": "389-392", "id_number": "CaltechAUTHORS:20130729-090934013", "isbn": "978-1-4673-5654-1", "book_title": "IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS)", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20130729-090934013", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "other_numbering_system": { "items": [ { "id": "13369904", "name": "INSPEC Accession Number" } ] }, "doi": "10.1109/MEMSYS.2013.6474260", "resource_type": "book_section", "pub_year": "2013", "author_list": "Kang, Dongyang; Standley, Andrew; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/ymwfe-01248", "eprint_id": 39615, "eprint_status": "archive", "datestamp": "2023-08-19 14:13:40", "lastmod": "2023-10-24 16:59:49", "type": "book_section", "metadata_visibility": "show", "creators": { "items": [ { "id": "Chang-Jay-Han-Chieh", "name": { "family": "Chang", "given": "Jay Han-Chieh" } }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Kang-Dongyang", "name": { "family": "Kang", "given": "Dongyang" } }, { "id": "Monge-Manuel", "name": { "family": "Monge", "given": "Manuel" }, "orcid": "0000-0001-9799-0693" }, { "id": "Zhao-Yu", "name": { "family": "Zhao", "given": "Yu" } }, { "id": "Yu-Chia-Chen", "name": { "family": "Yu", "given": "Chia-Chen" } }, { "id": "Emami-A", "name": { "family": "Emami-Neyestanak", "given": "Azita" }, "orcid": "0000-0002-6945-9958" }, { "id": "Weiland-J-D", "name": { "family": "Weiland", "given": "James" } }, { "id": "Humayun-M-S", "name": { "family": "Humayun", "given": "Mark" }, "orcid": "0000-0002-5830-5208" }, { "id": "Tai-Yu-Chong", "name": { "family": "Tai", "given": "Yu-Chong" }, "orcid": "0000-0001-8529-106X" } ] }, "title": "Packaging study for a 512-channel intraocular epiretinal implant", "ispublished": "unpub", "full_text_status": "restricted", "note": "\u00a9 2013 IEEE.\n\nThis work is supported by Biomimetic\nMicroElectronic Systems (BMES). The authors would also\nlike to thank Mr. Trevor Roper and other lab members of\nthe Caltech Micromachining Laboratory for assistance\nwith fabrication and fruitful discussion.", "abstract": "Much effort has been put into developing multi-channel retinal prosthetic devices. Currently, even the most advanced prostheses do not have enough channels to provide vision to a desirable level. In this paper, we present a system design and a packaging scheme for a 512-channel intraocular epiretinal implant. Both a wireless power coil (with high transfer efficiency) and a data coil are included for this intraocular system. Simulation of the interference between coils is investigated and the results show that the two coils can be put in a co-planar fashion using two notch filters to minimize interference. The complete package is demonstrated with a mechanical model with a parylene-C flexible circuit board, i.e., parylene flex, to show the placement of the IC chips, discrete components, and coils. It also shows the final folded device after surgical insertion into an eye to save space. The feasibility of the proposed structure has been successfully tested in vivo. Experimentally, the maximum allowable pulling force is measured by a dynamic mechanical analysis (DMA) machine to be 8N, which provides a large safety margin for surgery.", "date": "2013-01", "date_type": "published", "publisher": "IEEE", "place_of_pub": "Piscataway, NJ", "pagerange": "1045-1048", "id_number": "CaltechAUTHORS:20130729-090047591", "isbn": "978-1-4673-5654-1", "book_title": "IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS)", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20130729-090047591", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Biomimetic MicroElectronic Systems (BMES)" } ] }, "doi": "10.1109/MEMSYS.2013.6474428", "resource_type": "book_section", "pub_year": "2013", "author_list": "Chang, Jay Han-Chieh; Liu, Yang; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/j5n70-hhx89", "eprint_id": 29800, "eprint_status": "archive", "datestamp": "2023-08-22 04:38:02", "lastmod": "2023-10-24 22:27:57", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Sun-Minwei", "name": { "family": "Sun", "given": "Minwei" } }, { "id": "Hunt-H-K", "name": { "family": "Hunt", "given": "Heather K." } }, { "id": "Lew-C-M", "name": { "family": "Lew", "given": "Christopher M." } }, { "id": "Cai-Rui", "name": { "family": "Cai", "given": "Rui" } }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Yan-Yushan", "name": { "family": "Yan", "given": "Yushan" } } ] }, "title": "A Dynamic Organic Structuring-Directing Agent for Pure-Silica-Zeolite AST and LTA Syntheses", "ispublished": "pub", "full_text_status": "restricted", "keywords": "zeolite; synthesis; dynamic structure-directing agent; \u03c0-\u03c0 conjugation; Liebau's rules", "note": "\u00a9 2012 Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier BV.\nReceived 23 August 2011. Accepted 2 October 2011. Available online 7 February 2012.\nThis work was supported by the NSF (Grant CTS-0404376).", "abstract": "Pure-silica-zeolite (PSZ) AST and LTA are synthesized successfully by using the same structure-directing agent (SDA) molecule, but at different concentrations. A dynamic organic SDA is proposed to discuss the mechanism of phase discrimination between AST and LTA. Data suggest that the SDA molecules can self-assemble into dimer or trimer complexes at different concentrations by \u03c0-\u03c0 interactions, and these differences can be taken advantage of to selectively synthesize either PSZ AST or LTA. These deviations from the Liebau's rules indicate that small changes in SDA chemistry, structure, and order in solution can have a great impact on the structure selectivity of the zeolite synthesis.", "date": "2012-01", "date_type": "published", "publication": "Chinese Journal of Catalysis", "volume": "33", "number": "1", "publisher": "Science Press", "pagerange": "85-91", "id_number": "CaltechAUTHORS:20120321-153915274", "issn": "0253-9837", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20120321-153915274", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NSF", "grant_number": "CTS-0404376" } ] }, "doi": "10.1016/S1872-2067(10)60291-4", "resource_type": "article", "pub_year": "2012", "author_list": "Sun, Minwei; Hunt, Heather K.; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/cs8tx-m1q28", "eprint_id": 15597, "eprint_status": "archive", "datestamp": "2023-08-20 01:14:36", "lastmod": "2023-10-19 14:37:24", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Nkansah-R-A", "name": { "family": "Nkansah", "given": "Richard A." } }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Alley-O-J", "name": { "family": "Alley", "given": "Olivia J." } }, { "id": "Gerken-J-B", "name": { "family": "Gerken", "given": "James B." } }, { "id": "Drake-M-D", "name": { "family": "Drake", "given": "Michael D." } }, { "id": "Roberts-J-D", "name": { "family": "Roberts", "given": "John D." } } ] }, "title": "Conformational Preferences of 3-(Dimethylazinoyl)propanoic Acid as a Function of pH and Solvent; Intermolecular versus Intramolecular Hydrogen Bonding", "ispublished": "pub", "full_text_status": "public", "note": "\u00a9 2009 American Chemical Society.\nReceived November 6, 2008.\nPublication Date (Web): February 26, 2009\nAcknowledgement is made to the donors\nof the Petroleum Research Fund administered by the American\nChemical Society for their support of this research. This material\nhere is also based upon work supported by the National Science\nFoundation under Grant CHE-0543620, the Summer Undergraduate\nResearch Fellowship Program (SURF) at the California\nInstitute of Technology, and the Senior Scientist Mentor\nProgram of the Camille and Henry Dreyfus Foundation. In\naddition, we are indebted to Merck & Company, Dr. & Mrs.\nChester M. McCloskey, Dr. David J. Mathre, and Edith M.\nRoberts for their helpful financial assistance. The authors wish\nto thank Dr. Scott Ross and Maya Popova for their help and\nguidance.\nSupporting Information Available: Characterization, computational\ndata, and Altona equations used for the calculations\nof percent gauche of DMAPA in protic and aprotic solvents.\nAlso included is the unpublished research by P.V. Jog.2 This\nmaterial is available free of charge via the Internet at\nhttp://pubs.acs.org.\n\nSupplemental Material - Nkansah2009p71610.1021jo802488k_supp.pdf
", "abstract": "The conformational equilibrium of 3-(dimethylazinoyl)propanoic acid (DMAPA, azinoyl = N^+(O^\u2212) has a weak pH-dependence in D_2O, with a slight preference for trans in alkaline solutions. The acid ionization constants of the protonated amine oxide and carboxylic functional groups as determined by NMR spectroscopy were 7.9 \u00d7 10^(\u22124) and 6.3 \u00d7 10^(\u22126), respectively. The corresponding value of K_1/K_2 of 1.3 \u00d7 10^2 is not deemed large enough to provide experimental NMR evidence for a significant degree of intramolecular hydrogen bonding in D_2O. Conformational preferences of DMAPA are mostly close to statistical (gauche/trans = 2/1) in other protic solvents, e.g., alcohols. However, the un-ionized form of DMAPA appears to be strongly intramolecularly hydrogen-bonded and gauche in aprotic solvents.", "date": "2009-03-20", "date_type": "published", "publication": "Journal of Organic Chemistry", "volume": "74", "number": "6", "publisher": "American Chemical Society", "pagerange": "2344-2349", "id_number": "CaltechAUTHORS:20090904-083008660", "issn": "0022-3263", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20090904-083008660", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NSF", "grant_number": "CHE-0543620" }, { "agency": "Summer Undergraduate Research Fellowship Program (SURF)" }, { "agency": "Camille and Henry Dreyfus Foundation" } ] }, "doi": "10.1021/jo802488k", "primary_object": { "basename": "Nkansah2009p71610.1021jo802488k_supp.pdf", "url": "https://authors.library.caltech.edu/records/cs8tx-m1q28/files/Nkansah2009p71610.1021jo802488k_supp.pdf" }, "resource_type": "article", "pub_year": "2009", "author_list": "Nkansah, Richard A.; Liu, Yang; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/mfv33-s0m89", "eprint_id": 15514, "eprint_status": "archive", "datestamp": "2023-08-21 21:02:21", "lastmod": "2023-10-19 14:31:23", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Rich-R-L", "name": { "family": "Rich", "given": "Rebecca L." } }, { "id": "Papalia-G-A", "name": { "family": "Papalia", "given": "Giuseppe A." } }, { "id": "Flynn-P-J", "name": { "family": "Flynn", "given": "Peter J." } }, { "id": "Furneisen-J", "name": { "family": "Furneisen", "given": "Jamie" } }, { "id": "Quinn-J", "name": { "family": "Quinn", "given": "John" } }, { "id": "Klein-J-S", "name": { "family": "Klein", "given": "Joshua S." } }, { "id": "Katsamba-P-S", "name": { "family": "Katsamba", "given": "Phini S." } }, { "id": "Waddell-M-B", "name": { "family": "Waddell", "given": "M. Brent" } }, { "id": "Scott-M", "name": { "family": "Scott", "given": "Michael" } }, { "id": "Thompson-J", "name": { "family": "Thompson", "given": "Joshua" } }, { "id": "Berlier-J", "name": { "family": "Berlier", "given": "Judie" } }, { "id": "Corry-S", "name": { "family": "Corry", "given": "Schuyler" } }, { "id": "Baltzinger-M", "name": { "family": "Baltzinger", "given": "Mireille" } }, { "id": "Zeder-Lutz-G", "name": { "family": "Zeder-Lutz", "given": "Gabrielle" } }, { "id": "Schoenemann-A", "name": { "family": "Schoenemann", "given": "Andreas" } }, { "id": "Clabbers-A", "name": { "family": "Clabbers", "given": "Anca" } }, { "id": "Wieckowski-S", "name": { "family": "Wieckowski", "given": "Sebastien" } }, { "id": "Murphy-M-M", "name": { "family": "Murphy", "given": "Mary M." } }, { "id": "Page-P", "name": { "family": "Page", "given": "Phillip" } }, { "id": "Ryan-T-E", "name": { "family": "Ryan", "given": "Thomas E." } }, { "id": "Duffner-J", "name": { "family": "Duffner", "given": "Jay" } }, { "id": "Ganguly-T", "name": { "family": "Ganguly", "given": "Tanmoy" } }, { "id": "Corbin-J", "name": { "family": "Corbin", "given": "John" } }, { "id": "Gautam-S", "name": { "family": "Gautam", "given": "Satyen" } }, { "id": "Anderluh-G", "name": { "family": "Anderluh", "given": "Gregor" } }, { "id": "Bavdek-A", "name": { "family": "Bavdek", "given": "Andrej" } }, { "id": "Reichmann-D", "name": { "family": "Reichmann", "given": "Dana" } }, { "id": "Yadav-S-P", "name": { "family": "Yadav", "given": "Satya P." } }, { "id": "Hommema-E", "name": { "family": "Hommema", "given": "Eric" } }, { "id": "Pol-E", "name": { "family": "Pol", "given": "Ewa" } }, { "id": "Drake-A", "name": { "family": "Drake", "given": "Andrew" } }, { "id": "Klakamp-S", "name": { "family": "Klakamp", "given": "Scott" } }, { "id": "Chapman-T", "name": { "family": "Chapman", "given": "Trevor" } }, { "id": "Kernaghan-D", "name": { "family": "Kernaghan", "given": "Dawn" } }, { "id": "Miller-K", "name": { "family": "Miller", "given": "Ken" } }, { "id": "Schuman-J", "name": { "family": "Schuman", "given": "Jason" } }, { "id": "Lindquist-K", "name": { "family": "Lindquist", "given": "Kevin" } }, { "id": "Herlihy-K", "name": { "family": "Herlihy", "given": "Kara" } }, { "id": "Murphy-M-B", "name": { "family": "Murphy", "given": "Michael B." } }, { "id": "Bohnsack-R", "name": { "family": "Bohnsack", "given": "Richard" } }, { "id": "Andrien-B", "name": { "family": "Andrien", "given": "Bruce" } }, { "id": "Brandani-P", "name": { "family": "Brandani", "given": "Pietro" } }, { "id": "Terwey-D", "name": { "family": "Terwey", "given": "Danny" } }, { "id": "Millican-R", "name": { "family": "Millican", "given": "Rohn" } }, { "id": "Darling-R-J", "name": { "family": "Darling", "given": "Ryan J." } }, { "id": "Wangae-L", "name": { "family": "Wangae", "given": "Liann" } }, { "id": "Carter-Q", "name": { "family": "Carter", "given": "Quincy" } }, { "id": "Dotzlaf-J", "name": { "family": "Dotzlaf", "given": "Joe" } }, { "id": "Lopez-Sagaseta-J", "name": { "family": "Lopez-Sagaseta", "given": "Jacinto" } }, { "id": "Campbell-I", "name": { "family": "Campbell", "given": "Islay" } }, { "id": "Torreri-P", "name": { "family": "Torreri", "given": "Paola" } }, { "id": "Hoos-S", "name": { "family": "Hoos", "given": "Sylviane" } }, { "id": "England-P", "name": { "family": "England", "given": "Patrick" } }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Abdiche-Y", "name": { "family": "Abdiche", "given": "Yasmina" } }, { "id": "Malashock-D", "name": { "family": "Malashock", "given": "Daniel" } }, { "id": "Pinkerton-A", "name": { "family": "Pinkerton", "given": "Alanna" } }, { "id": "Wong-Melanie", "name": { "family": "Wong", "given": "Melanie" } }, { "id": "Lafer-E", "name": { "family": "Lafer", "given": "Eileen" } }, { "id": "Hinck-C", "name": { "family": "Hinck", "given": "Cynthia" } }, { "id": "Thompson-K", "name": { "family": "Thompson", "given": "Kevin" } }, { "id": "Di-Primo-C", "name": { "family": "Di Primo", "given": "Carmelo" } }, { "id": "Joyce-A", "name": { "family": "Joyce", "given": "Alison" } }, { "id": "Brooks-J", "name": { "family": "Brooks", "given": "Jonathan" } }, { "id": "Torta-F", "name": { "family": "Torta", "given": "Federico" } }, { "id": "Bagge-Hagel-A-B", "name": { "family": "Bagge Hagel", "given": "Anne Birgitte" } }, { "id": "Krarup-J", "name": { "family": "Krarup", "given": "Janus" } }, { "id": "Pass-J", "name": { "family": "Pass", "given": "Jesper" } }, { "id": "Ferreira-M", "name": { "family": "Ferreira", "given": "Monica" } }, { "id": "Shikov-S", "name": { "family": "Shikov", "given": "Sergei" } }, { "id": "Mikolajczyk-M", "name": { "family": "Mikolajczyk", "given": "Malgorzata" } }, { "id": "Abe-Yuki", "name": { "family": "Abe", "given": "Yuki" } }, { "id": "Barbato-G", "name": { "family": "Barbato", "given": "Gaetano" } }, { "id": "Giannetti-A-M", "name": { "family": "Giannetti", "given": "Anthony M." } }, { "id": "Krishnamoorthy-G", "name": { "family": "Krishnamoorthy", "given": "Ganeshram" } }, { "id": "Beusink-B", "name": { "family": "Beusink", "given": "Bianca" } }, { "id": "Satpaev-D", "name": { "family": "Satpaev", "given": "Daulet" } }, { "id": "Tsang-Tiffany", "name": { "family": "Tsang", "given": "Tiffany" } }, { "id": "Fang-Eric", "name": { "family": "Fang", "given": "Eric" } }, { "id": "Partridge-J", "name": { "family": "Partridge", "given": "James" } }, { "id": "Brohawn-S", "name": { "family": "Brohawn", "given": "Stephen" } }, { "id": "Horn-J", "name": { "family": "Horn", "given": "James" } }, { "id": "Pritsch-O", "name": { "family": "Pritsch", "given": "Otto" } }, { "id": "Obal-G", "name": { "family": "Obal", "given": "Gonzalo" } }, { "id": "Nilapwar-S", "name": { "family": "Nilapwar", "given": "Sanjay" } }, { "id": "Busby-B", "name": { "family": "Busby", "given": "Ben" } }, { "id": "Gutierrez-Sanchez-G", "name": { "family": "Gutierrez-Sanchez", "given": "Gerardo" } }, { "id": "Das-Gupta-R", "name": { "family": "Das Gupta", "given": "Ruchira" } }, { "id": "Canepa-S", "name": { "family": "Canepa", "given": "Sylvie" } }, { "id": "Witte-K", "name": { "family": "Witte", "given": "Krista" } }, { "id": "Nikolovska-Coleska-Z", "name": { "family": "Nikolovska-Coleska", "given": "Zaneta" } }, { "id": "Cho-Yun-Hee", "name": { "family": "Cho", "given": "Yun Hee" } }, { "id": "D'Agata-R", "name": { "family": "D'Agata", "given": "Roberta" } }, { "id": "Schlick-K", "name": { "family": "Schlick", "given": "Kristian" } }, { "id": "Calvert-R", "name": { "family": "Calvert", "given": "Rosy" } }, { "id": "Munoz-E-M", "name": { "family": "Munoz", "given": "Eva M." } }, { "id": "Hernaiz-M-J", "name": { "family": "Hernaiz", "given": "Maria Jose" } }, { "id": "Bravman-T", "name": { "family": "Bravman", "given": "Tsafir" } }, { "id": "Dines-M", "name": { "family": "Dines", "given": "Monica" } }, { "id": "Yang-Min-Hsiang", "name": { "family": "Yang", "given": "Min-Hsiang" } }, { "id": "Puskas-A", "name": { "family": "Puskas", "given": "Agnes" } }, { "id": "Boni-E", "name": { "family": "Boni", "given": "Erica" } }, { "id": "Li-Jiejin", "name": { "family": "Li", "given": "Jiejin" } }, { "id": "Wear-M", "name": { "family": "Wear", "given": "Martin" } }, { "id": "Grinberg-A", "name": { "family": "Grinberg", "given": "Asya" } }, { "id": "Baardsnes-J", "name": { "family": "Baardsnes", "given": "Jason" } }, { "id": "Dolezal-O", "name": { "family": "Dolezal", "given": "Olan" } }, { "id": "Gainey-M", "name": { "family": "Gainey", "given": "Melicia" } }, { "id": "Anderson-H", "name": { "family": "Anderson", "given": "Henrik" } }, { "id": "Peng-Jinlin", "name": { "family": "Peng", "given": "Jinlin" } }, { "id": "Lewis-M", "name": { "family": "Lewis", "given": "Mark" } }, { "id": "Spies-P", "name": { "family": "Spies", "given": "Peter" } }, { "id": "Trinh-Quyhn", "name": { "family": "Trinh", "given": "Quyhn" } }, { "id": "Bibikov-S", "name": { "family": "Bibikov", "given": "Sergei" } }, { "id": "Raymond-J", "name": { "family": "Raymond", "given": "Jill" } }, { "id": "Yousef-M", "name": { "family": "Yousef", "given": "Mohammed" } }, { "id": "Chandrasekaran-V", "name": { "family": "Chandrasekaran", "given": "Vidya" } }, { "id": "Feng-Yuguo", "name": { "family": "Feng", "given": "Yuguo" } }, { "id": "Emerick-Anne", "name": { "family": "Emerick", "given": "Anne" } }, { "id": "Mundodo-S", "name": { "family": "Mundodo", "given": "Suparna" } }, { "id": "Guimaraes-R", "name": { "family": "Guimaraes", "given": "Rejane" } }, { "id": "McGirr-K", "name": { "family": "McGirr", "given": "Katy" } }, { "id": "Li-Yue-Ji", "name": { "family": "Li", "given": "Yue-Ji" } }, { "id": "Hughes-H", "name": { "family": "Hughes", "given": "Heather" } }, { "id": "Mantz-H", "name": { "family": "Mantz", "given": "Hubert" } }, { "id": "Skrabana-R", "name": { "family": "Skrabana", "given": "Rostislav" } }, { "id": "Witmer-M", "name": { "family": "Witmer", "given": "Mark" } }, { "id": "Ballard-J", "name": { "family": "Ballard", "given": "Joshua" } }, { "id": "Martin-L", "name": { "family": "Martin", "given": "Loic" } }, { "id": "Skladal-P", "name": { "family": "Skladal", "given": "Petr" } }, { "id": "Korza-G", "name": { "family": "Korza", "given": "George" } }, { "id": "Laird-Offringa-I", "name": { "family": "Laird-Offringa", "given": "Ite" } }, { "id": "Lee-Charlene-S", "name": { "family": "Lee", "given": "Charlene S." } }, { "id": "Khadir-A", "name": { "family": "Khadir", "given": "Abdelkrim" } }, { "id": "Podlaski-F", "name": { "family": "Podlaski", "given": "Frank" } }, { "id": "Neuner-P", "name": { "family": "Neuner", "given": "Phillippe" } }, { "id": "Rothacker-J", "name": { "family": "Rothacker", "given": "Julie" } }, { "id": "Rafique-A", "name": { "family": "Rafique", "given": "Ashique" } }, { "id": "Dankbar-N", "name": { "family": "Dankbar", "given": "Nico" } }, { "id": "Kainz-P", "name": { "family": "Kainz", "given": "Peter" } }, { "id": "Gedig-E", "name": { "family": "Gedig", "given": "Erk" } }, { "id": "Vuyisich-M", "name": { "family": "Vuyisich", "given": "Momchilo" } }, { "id": "Boozer-C", "name": { "family": "Boozer", "given": "Christina" } }, { "id": "Ly-Nguyen", "name": { "family": "Ly", "given": "Nguyen" } }, { "id": "Toews-M", "name": { "family": "Toews", "given": "Mark" } }, { "id": "Uren-A", "name": { "family": "Uren", "given": "Aykut" } }, { "id": "Kalyuzhniy-O", "name": { "family": "Kalyuzhniy", "given": "Oleksandr" } }, { "id": "Lewis-K", "name": { "family": "Lewis", "given": "Kenneth" } }, { "id": "Chomey-E", "name": { "family": "Chomey", "given": "Eugene" } }, { "id": "Pak-Brian-J", "name": { "family": "Pak", "given": "Brian J." } }, { "id": "Myszka-D-G", "name": { "family": "Myszka", "given": "David G." } } ] }, "title": "A global benchmark study using affinity-based biosensors", "ispublished": "pub", "full_text_status": "public", "keywords": "Biacore; Kinetics; Optical biosensor; Surface plasmon resonance", "note": "\u00a9 2009 Elsevier B.V. \n\nReceived 3 October 2008. Available online 27 November 2008. \n\nWe thank KaloBios Pharmaceuticals for providing the purified\nFab and GST\u2013Ag, Biacore/GE Healthcare for providing sensor chips\nto help develop this model system, and Bio-Rad Laboratories for\nshipping all of the sample sets worldwide.\n\nAccepted Version - nihms500790.pdf
", "abstract": "To explore the variability in biosensor studies, 150 participants from 20 countries were given the same protein samples and asked to determine kinetic rate constants for the interaction. We chose a protein system that was amenable to analysis using different biosensor platforms as well as by users of different expertise levels. The two proteins (a 50-kDa Fab and a 60-kDa glutathione S-transferase [GST] antigen) form a relatively high-affinity complex, so participants needed to optimize several experimental parameters, including ligand immobilization and regeneration conditions as well as analyte concentrations and injection/dissociation times. Although most participants collected binding responses that could be fit to yield kinetic parameters, the quality of a few data sets could have been improved by optimizing the assay design. Once these outliers were removed, the average reported affinity across the remaining panel of participants was 620 pM with a standard deviation of 980 pM. These results demonstrate that when this biosensor assay was designed and executed appropriately, the reported rate constants were consistent, and independent of which protein was immobilized and which biosensor was used.", "date": "2009-03-15", "date_type": "published", "publication": "Analytical Biochemistry", "volume": "386", "number": "2", "publisher": "Elsevier", "pagerange": "194-216", "id_number": "CaltechAUTHORS:20090901-094826364", "issn": "0003-2697", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20090901-094826364", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "doi": "10.1016/j.ab.2008.11.021", "pmcid": "PMC3793259", "primary_object": { "basename": "nihms500790.pdf", "url": "https://authors.library.caltech.edu/records/mfv33-s0m89/files/nihms500790.pdf" }, "resource_type": "article", "pub_year": "2009", "author_list": "Rich, Rebecca L.; Papalia, Giuseppe A.; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/e8c2x-j2493", "eprint_id": 55584, "eprint_status": "archive", "datestamp": "2023-08-22 10:57:14", "lastmod": "2023-10-20 22:24:34", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Yang-Fu-Chia", "name": { "family": "Yang", "given": "Fu-Chia" } }, { "id": "Okuda-Tsukasa", "name": { "family": "Okuda", "given": "Tsukasa" } }, { "id": "Dong-Xinzhong", "name": { "family": "Dong", "given": "Xinzhong" } }, { "id": "Zylka-Mark-J", "name": { "family": "Zylka", "given": "Mark J." } }, { "id": "Chen-Chih-Li", "name": { "family": "Chen", "given": "Chih-Li" } }, { "id": "Anderson-D-J", "name": { "family": "Anderson", "given": "David J." }, "orcid": "0000-0001-6175-3872" }, { "id": "Kuner-Rohini", "name": { "family": "Kuner", "given": "Rohini" } }, { "id": "Ma-Qiufu", "name": { "family": "Ma", "given": "Qiufu" } } ] }, "title": "Mechanisms of Compartmentalized Expression of Mrg Class G-Protein-Coupled Sensory Receptors", "ispublished": "pub", "full_text_status": "public", "keywords": "Runx1; nociceptors; Mrg class G-protein-coupled receptors; nociceptive ion channels and receptors; cell type specification; dorsal root ganglia", "note": "\u00a9 2008 Society for Neuroscience. \n\nReceived June 5, 2007; revised Nov. 9, 2007; accepted Nov. 14, 2007. \n\nThe work was supported by National Institutes of Health (NIH)\u2013National Institute of Neurological Disorders and Stroke Training Grant 5T32NS007473-09 (F.-C.Y.), NIH\u2013National Institute of Dental and Craniofacial Research Grant 1R01DE018025 (Q.M.), and NIH\u2013National Institute of Neurological Disorders and Stroke Grant 5P01NS047572 (Q.M.). Q.M. is a Claudia Adams Barr Scholar. We thank Drs. Gary Gilliland and Nancy Speck for the Runx1 conditional\nknock-out mice, Chuxia Deng for conditional Smad4 null mice, David Rowitch for Wnt1-Cre mice, Tom Jessell for the Runx1 antibody, and Keith Ligon for critical comments on this manuscript.\n\nPublished - 125.full.pdf
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", "abstract": "Mrg class G-protein-coupled receptors (GPCRs) are expressed exclusively in sensory neurons in the trigeminal and dorsal root ganglia. Pharmacological activation of Mrg proteins is capable of modulating sensory neuron activities and elicits nociceptive effects. In this study, we illustrate a control mechanism that allows the Runx1 runt domain transcription factor to generate compartmentalized expression of these sensory GPCRs. Expression of MrgA, MrgB, and MrgC subclasses is confined to an \"A/B/C\" neuronal compartment that expresses Runx1 transiently (or does not express Runx1), whereas MrgD expression is restricted to a \"D\" compartment with persistent Runx1 expression. Runx1 is initially required for the expression of all Mrg genes. However, during late development Runx1 becomes a repressor for MrgA/B/C genes. As a result, MrgA/B/C expression persists only in the Runx1^\u2212 \"A/B/C\" compartment. In \u0394446 mice, in which Runx1 lacks the C-terminal repression domain, expression of MrgA/B/C genes is dramatically expanded into the Runx1^+ \"D\" compartment. MrgD expression, however, is resistant to Runx1-mediated repression in the \"D\" compartment. Therefore, the creation of Runx1+ and Runx1^\u2212 compartments, in conjunction with different responses of Mrg genes to Runx1-mediated repression, results in the compartmentalized expression of MrgA/B/C versus MrgD genes. Within the MrgA/B/C compartment, MrgB4-expressing neurons innervate exclusively the hairy skin. Here we found that Smad4, a downstream component of bone morphological protein-mediated signaling, is required selectively for the expression of MrgB4. Our study suggests a new line of evidence that specification of sensory subtypes is established progressively during perinatal and postnatal development.", "date": "2008-01-02", "date_type": "published", "publication": "Journal of Neuroscience", "volume": "28", "number": "1", "publisher": "Society for Neuroscience", "pagerange": "125-132", "id_number": "CaltechAUTHORS:20150306-094944495", "issn": "0270-6474", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20150306-094944495", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NIH Predoctoral Fellowship", "grant_number": "5T32NS007473-09" }, { "agency": "NIH", "grant_number": "1R01DE018025" }, { "agency": "NIH", "grant_number": "5P01NS047572" } ] }, "doi": "10.1523/JNEUROSCI.4472-07.2008", "pmcid": "PMC6671167", "primary_object": { "basename": "125.full.pdf", "url": "https://authors.library.caltech.edu/records/e8c2x-j2493/files/125.full.pdf" }, "related_objects": [ { "basename": "Supplementary_Figure_1.gif", "url": "https://authors.library.caltech.edu/records/e8c2x-j2493/files/Supplementary_Figure_1.gif" }, { "basename": "Supplementary_Figure_2.gif", "url": "https://authors.library.caltech.edu/records/e8c2x-j2493/files/Supplementary_Figure_2.gif" }, { "basename": "Supplementary_Figure_3.gif", "url": "https://authors.library.caltech.edu/records/e8c2x-j2493/files/Supplementary_Figure_3.gif" }, { "basename": "Supplementary_Figure_4.gif", "url": "https://authors.library.caltech.edu/records/e8c2x-j2493/files/Supplementary_Figure_4.gif" }, { "basename": "Supplementary_Figure_legends.pdf", "url": "https://authors.library.caltech.edu/records/e8c2x-j2493/files/Supplementary_Figure_legends.pdf" } ], "resource_type": "article", "pub_year": "2008", "author_list": "Liu, Yang; Yang, Fu-Chia; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/qbvrc-x5e67", "eprint_id": 75420, "eprint_status": "archive", "datestamp": "2023-08-21 21:57:45", "lastmod": "2023-10-25 15:02:10", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Misulovin-Z", "name": { "family": "Misulovin", "given": "Ziva" } }, { "id": "Bjorkman-P-J", "name": { "family": "Bjorkman", "given": "Pamela J." }, "orcid": "0000-0002-2277-3990" } ] }, "title": "The molecular mechanism of sulfated carbohydrate recognition by the cysteine-rich domain of mannose receptor", "ispublished": "pub", "full_text_status": "restricted", "keywords": "\u03b2-trefoil protein; fluorescence spectrophotometery; mannose receptor; pituitary hormones; sulfated carbohydrates", "note": "\u00a9 2001 Academic Press. \n\nReceived 20 August 2000, Revised 1 November 2000, Accepted 6 November 2000. \n\nWe thank Ten Feizi, Christine Leteux, Heide Kogelberg, and members of the Bjorkman laboratory for critical reading of the manuscript, and Michel Nussenzweig for contributions to earlier phases of the project. \n\nData bank accession numbers: Coordinates have been deposited in the RCSB Protein Data Bank under accession codes 1FWV (3-SO4-Lewisa complex) and 1FWU (3-SO4-Lewisx complex).", "abstract": "The mannose receptor (MR) binds foreign and host ligands through interactions with their carbohydrates. Two portions of MR have distinct carbohydrate recognition properties. One is conferred by the amino-terminal cysteine-rich domain (Cys-MR), which plays a critical role in binding sulfated glycoproteins including pituitary hormones. The other is achieved by tandemly arranged C-type lectin domains that facilitate carbohydrate-dependent uptake of infectious microorganisms. This dual carbohydrate binding specificity enables MR to bind ligands by interacting with both sulfated and non-sulfated polysaccharide chains. We previously determined crystal structures of Cys-MR complexed with 4-SO_4-N-acetylglucosamine and with an unidentified ligand resembling Hepes (N-[2-hydroxyethyl]piperazine-N\u2032-[2-ethanesulfonic acid]). In continued efforts to elucidate the mechanism of sulfated carbohydrate recognition by Cys-MR, we characterized the binding affinities between Cys-MR and potential carbohydrate ligands using a fluorescence-based assay. We find that Cys-MR binds sulfated carbohydrates with relatively high affinities (K_D=0.1 mM to 1.0 mM) compared to the affinities of other lectins. Cys-MR also binds Hepes with a K_D value of 3.9 mM, consistent with the suggestion that the ligand in the original Cys-MR crystal structure is Hepes. We also determined crystal structures of Cys-MR complexed with 3-SO_4-Lewis^x, 3-SO_4-Lewis^a, and 6-SO_4-N-acetylglucosamine at 1.9 \u00c5, 2.2 \u00c5, and 2.5 \u00c5 resolution, respectively, and the 2.0 \u00c5 structure of Cys-MR that had been treated to remove Hepes. The conformation of the Cys-MR binding site is virtually identical in all Cys-MR crystal structures, suggesting that Cys-MR does not undergo conformational changes upon ligand binding. The structures are used to rationalize the binding affinities derived from the biochemical studies and to elucidate the molecular mechanism of sulfated carbohydrate recognition by Cys-MR.", "date": "2001-01-19", "date_type": "published", "publication": "Journal of Molecular Biology", "volume": "305", "number": "3", "publisher": "Elsevier", "pagerange": "481-490", "id_number": "CaltechAUTHORS:20170327-125328321", "issn": "0022-2836", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20170327-125328321", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "doi": "10.1006/jmbi.2000.4326", "resource_type": "article", "pub_year": "2001", "author_list": "Liu, Yang; Misulovin, Ziva; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/55etz-3cw15", "eprint_id": 28237, "eprint_status": "archive", "datestamp": "2023-08-21 21:04:41", "lastmod": "2023-10-24 17:45:27", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Chirino-A-J", "name": { "family": "Chirino", "given": "Arthur J." } }, { "id": "Misulovin-Z", "name": { "family": "Misulovin", "given": "Ziva" } }, { "id": "Leteux-C", "name": { "family": "Leteux", "given": "Christine" } }, { "id": "Feizi-Ten", "name": { "family": "Feizi", "given": "Ten" } }, { "id": "Nussenzweig-M-C", "name": { "family": "Nussenzweig", "given": "Michel C." }, "orcid": "0000-0003-0592-8564" }, { "id": "Bjorkman-P-J", "name": { "family": "Bjorkman", "given": "Pamela J." }, "orcid": "0000-0002-2277-3990" } ] }, "title": "Crystal Structure of the Cysteine-Rich Domain of Mannose Receptor Complexed with a Sulfated Carbohydrate Ligand", "ispublished": "pub", "full_text_status": "public", "keywords": "\u03b2-trefoil protein; hydrogen bond network; multilectin receptor; pituitary\nhormones; sulfated GalNAc", "note": "\u00a9 2000 The Rockefeller University Press.\n\nSubmitted: 7 December 1999;\nRevised: 27 January 2000;\nAccepted: 4 February 2000.\nWe thank S. Gordon and L. Mart\u00ednez-Pomares for the Cys-MR-Fc\nexpression vector, G. Hathaway and the California Institute of\nTechnology's Protein/Peptide Micro Analytical Laboratory for\npeptide analyses, M.J. Bennett, A.P. Yeh, L.M. Sanchez, H.J. Chiu,\nS. Ding, and M. Williamson for crystallographic assistance, and\nW.I. Weis, M.E. Taylor, and members of the Bjorkman laboratory\nfor critical reading of the manuscript. Coordinates have been submitted\nto the Protein Data Bank (available at www.rcsb.org/pdb/\nunder accession nos. IDQG and IDQO).\nThis work was supported by the Howard Hughes Medical Institute\n(P.J. Bjorkman and M.C. Nussenzweig) and grants from the\nNational Institutes of Health (M.C. Nussenzweig). Y. Liu was a recipient\nof Ferguson Fund predoctoral Fellowship and Teaching Assistantship\n(California Institute of Technology).\n\nPublished - LIUjem00.pdf
", "abstract": "The macrophage and epithelial cell mannose receptor (MR) binds carbohydrates on foreign and host molecules. Two portions of MR recognize carbohydrates: tandemly arranged C-type lectin domains facilitate carbohydrate-dependent macrophage uptake of infectious organisms, and the NH2-terminal cysteine-rich domain (Cys-MR) binds to sulfated glycoproteins including pituitary hormones. To elucidate the mechanism of sulfated carbohydrate recognition, we determined crystal structures of Cys-MR alone and complexed with 4-sulfated-N-acetylgalactosamine at 1.7 and 2.2 \u00c5 resolution, respectively. Cys-MR folds into an approximately three-fold symmetric \u03b2-trefoil shape resembling fibroblast growth factor. The sulfate portions of 4-sulfated-N-acetylgalactosamine and an unidentified ligand found in the native crystals bind in a neutral pocket in the third lobe. We use the structures to rationalize the carbohydrate binding specificities of Cys-MR and compare the recognition properties of Cys-MR with other \u03b2-trefoil proteins.", "date": "2000-04-03", "date_type": "published", "publication": "Journal of Experimental Medicine", "volume": "191", "number": "7", "publisher": "Rockefeller University Press", "pagerange": "1105-1115", "id_number": "CaltechAUTHORS:20111129-160812983", "issn": "0022-1007", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20111129-160812983", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Howard Hughes Medical Institute (HHMI)" }, { "agency": "NIH" } ] }, "doi": "10.1084/jem.191.7.1105", "pmcid": "PMC2193177", "primary_object": { "basename": "LIUjem00.pdf", "url": "https://authors.library.caltech.edu/records/55etz-3cw15/files/LIUjem00.pdf" }, "resource_type": "article", "pub_year": "2000", "author_list": "Liu, Yang; Chirino, Arthur J.; et el." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/n0g19-1fh90", "eprint_id": 75755, "eprint_status": "archive", "datestamp": "2023-08-19 04:31:50", "lastmod": "2023-10-25 15:16:39", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Hanke-T", "name": { "family": "Hanke", "given": "Thomas" } }, { "id": "Takizawa-Hisao", "name": { "family": "Takizawa", "given": "Hisao" } }, { "id": "McMahon-C-W", "name": { "family": "McMahon", "given": "Christopher W." } }, { "id": "Busch-D-H", "name": { "family": "Busch", "given": "Dirk H." } }, { "id": "Pamer-E-G", "name": { "family": "Pamer", "given": "Eric G." } }, { "id": "Miller-J-D", "name": { "family": "Miller", "given": "Joseph D." } }, { "id": "Altman-J-D", "name": { "family": "Altman", "given": "John D." } }, { "id": "Liu-Yang", "name": { "family": "Liu", "given": "Yang" }, "orcid": "0000-0002-8155-9134" }, { "id": "Cado-D", "name": { "family": "Cado", "given": "Dragana" } }, { "id": "Lemonnier-F-A", "name": { "family": "Lemonnier", "given": "Francois A." } }, { "id": "Bjorkman-P-J", "name": { "family": "Bjorkman", "given": "Pamela J." }, "orcid": "0000-0002-2277-3990" }, { "id": "Raulet-D-H", "name": { "family": "Raulet", "given": "David H." } } ] }, "title": "Direct Assessment of MHC Class I Binding by Seven Ly49 Inhibitory NK Cell Receptors", "ispublished": "pub", "full_text_status": "restricted", "note": "\u00a9 1999 Cell Press. \n\nReceived 8 March 1999, Revised 20 May 1999. \n\nWe thank Peter Snow for production of the recombinant Dd from baculovirus, Vinay Kumar and Porunelloor Mathew for the cDNA library, Werner Held for Ly49A transgenic mice, Chern-sing Goh and Ann Lazar for technical assistance, and Russell Vance for critical reading of the manuscript. T. H. was a recipient of a Research Fellowship from the Deutsche Forschungsgemeinschaft, C. W. M. is the recipient of a Cancer Research Institute/Chase Manhattan Bank fellowship, and D. H. B. is a recipient of a Research Fellowship from the Howard Hughes Medical Institute. F. A. L. was supported by the Institut Pasteur. This work was supported by National Institutes of Health grant RO-1AI35021 to D. H. R.", "abstract": "Mouse NK cells express at least seven inhibitory Ly49 receptors. Here we employ a semiquantitative cell\u2013cell adhesion assay as well as class I/peptide tetramers to provide a comprehensive analysis of specificities of Ly49 receptors for class I MHC molecules in eight MHC haplotypes. Different Ly49 receptors exhibited diverse binding properties. The degree of class I binding was related to the extent of functional inhibition. The tetramer studies demonstrated that neither glycosylation nor coreceptors were necessary for class I binding to Ly49 receptors and uncovered peptide-specific recognition by a Ly49 receptor. The results provide a foundation for interpreting and integrating many existing functional studies as well as for designing tests of NK cell development and self-tolerance.", "date": "1999-07-01", "date_type": "published", "publication": "Immunity", "volume": "11", "number": "1", "publisher": "Elsevier", "pagerange": "67-77", "id_number": "CaltechAUTHORS:20170405-154817252", "issn": "1074-7613", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20170405-154817252", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "Deutsche Forschungsgemeinschaft (DFG)" }, { "agency": "Cancer Research Institute" }, { "agency": "Chase Manhattan Bank" }, { "agency": "Howard Hughes Medical Institute (HHMI)" }, { "agency": "Institut Pasteur" }, { "agency": "NIH", "grant_number": "RO-1AI35021" } ] }, "doi": "10.1016/S1074-7613(00)80082-5", "resource_type": "article", "pub_year": "1999", "author_list": "Hanke, Thomas; Takizawa, Hisao; et el." } ]