Lester, Henry

Article from CaltechAUTHORS

• Haloi, Nandan and Huang, Shan, el al. (2024) Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids; Protein Engineering, Design and Selection; Vol. 37; gzae003; PMCID PMC10896302; 10.1093/protein/gzae003
• Blumenfeld, Zack and Bera, Kallol, el al. (2023) Antidepressants enter cells, organelles, and membranes; Neuropsychopharmacology; 10.1038/s41386-023-01725-x
• Walker, Noah B. and Yan, Yijin, el al. (2023) β2 nAChR Activation on VTA DA Neurons Is Sufficient for Nicotine Reinforcement in Rats; eNeuro; Vol. 10; No. 5; Art. No. ENEURO.0449-22.2023; PMCID PMC10216253; 10.1523/eneuro.0449-22.2023
• Nichols, Aaron L. and Blumenfeld, Zack, el al. (2023) Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane; Journal of Neuroscience; Vol. 43; No. 13; 2222-2241; PMCID PMC10072302; 10.1523/jneurosci.1519-22.2022
• Knox, Hailey J. and Rego Campello, Hugo, el al. (2022) Characterization of Binding Site Interactions and Selectivity Principles in the α3β4 Nicotinic Acetylcholine Receptor; Journal of the American Chemical Society; Vol. 144; No. 35; 16101-16117; 10.1021/jacs.2c06495
• Harrison, Neil L. and Abbott, Geoffrey W., el al. (2022) How many SARS-CoV-2 "viroporins" are really ion channels?; Communications Biology; Vol. 5; No. 1; 10.1038/s42003-022-03669-2
• Muthusamy, Anand K. and Kim, Charlene H., el al. (2022) Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-Methadone for Use in Cells, Organelles, and Biofluids; Journal of the American Chemical Society; Vol. 144; No. 19; 8480-8486; PMCID PMC9121368; 10.1021/jacs.2c02323
• Nichols, Aaron L. and Blumenfeld, Zack, el al. (2022) Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands; eLife; Vol. 11; Art. No. e74648; PMCID PMC8820738; 10.7554/eLife.74648
• Mulcahy, Matthew J. and Huard, Stephanie M., el al. (2021) Protein profiling in the habenula after chronic (–)-menthol exposure in mice; Journal of Neurochemistry; Vol. 158; No. 6; 1345-1358; PMCID PMC8577691; 10.1111/jnc.15495
• Grant, Stephen N. and Lester, Henry A. (2021) Regulation of epithelial sodium channel activity by SARS-CoV-1 and SARS-CoV-2 proteins; Biophysical Journal; Vol. 120; No. 14; 2805-2813; PMCID PMC8238646; 10.1016/j.bpj.2021.06.005
• Unger, Elizabeth K. and Keller, Jacob P., el al. (2020) Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning; Cell; Vol. 183; No. 7; 1986-2002; PMCID PMC8025677; 10.1016/j.cell.2020.11.040
• Grant, Stephen and Lester, Henry A. (2020) Proteins for increased surface expression of the α6β4 nicotinic acetylcholine receptor: Nothing but good news?; Journal of Clinical Investigation; Vol. 130; No. 11; 5685-5687; PMCID PMC7598034; 10.1172/jci143197
• Grant, Stephen and Muthusamy, Anand K., el al. (2020) Antagonists Pharmacologically Chaperone Opioid Receptors; Biophysical Journal; Vol. 118; No. 3; 27a; 10.1016/j.bpj.2019.11.328
• Mulcahy, Matthew J. and Huard, Stephanie M., el al. (2020) Brain Region-Specific nAChR and Associated Protein Abundance Alterations Following Chronic Nicotine and/or Menthol Exposure; Journal of Proteome Research; Vol. 19; No. 1; 36-48; PMCID PMC7289315; 10.1021/acs.jproteome.9b00286
• Bera, Kallol and Kamajaya, Aron, el al. (2019) Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum; Frontiers in Cellular Neuroscience; Vol. 13; Art. No. 499; PMCID PMC6874132; 10.3389/fncel.2019.00499
• Lester, Henry A. and Dougherty, Dennis A. (2019) Nicotine Bound to Its Receptors: New Structures for a Vexing Pathopharmacological Problem; Neuron; Vol. 104; No. 3; 431-432; 10.1016/j.neuron.2019.10.029
• Blom, Annet E. M. and Rego Campello, Hugo, el al. (2019) Probing Binding Interactions of Cytisine Derivatives to the α4β2 Nicotinic Acetylcholine Receptor; Journal of the American Chemical Society; Vol. 141; No. 40; 15840-15849; 10.1021/jacs.9b06580
• Shivange, Amol V. and Borden, Philip M., el al. (2019) Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors; Journal of General Physiology; Vol. 151; No. 6; 738-757; PMCID PMC6571994; 10.1085/jgp.201812201
• Bavan, Selvan and Kim, Charlene H., el al. (2019) Chronic menthol does not change stoichiometry or functional plasma membrane levels of mouse α3β4-containing nicotinic acetylcholine receptors; Molecular Pharmacology; Vol. 95; No. 4; 398-407; PMCID PMC6399576; 10.1124/mol.118.114769
• Zhou, Chunyi and Gu, Weixin, el al. (2019) Bidirectional dopamine modulation of excitatory and inhibitory synaptic inputs to subthalamic neuron subsets containing α4β2 or α7 nAChRs; Neuropharmacology; Vol. 148; 220-228; 10.1016/j.neuropharm.2019.01.015
• Henderson, Brandon J. and Grant, Stephen, el al. (2018) Menthol stereoisomers exhibit different effects on α4β2 nAChR upregulation and dopamine neuron spontaneous firing; eNeuro; Vol. 5; No. 6; Art. No. e0465-18.2018; PMCID PMC6325563; 10.1523/eneuro.0465-18.2018
• Nichols, Aaron L. and Noridomi, Kaori, el al. (2018) α1-FANGs: Protein Ligands Selective for the α-Bungarotoxin Site of the α1-Nicotinic Acetylcholine Receptor; ACS Chemical Biology; Vol. 13; No. 9; 2568-2576; PMCID PMC8763392; 10.1021/acschembio.8b00513
• Subramaniam, Sudhakar R. and Magen, Iddo, el al. (2018) Chronic nicotine improves cognitive and social impairment in mice overexpressing wild type α-synuclein; Neurobiology of Disease; Vol. 117; 170-180; PMCID PMC6051902; 10.1016/j.nbd.2018.05.018
• Banala, Sambashiva and Arvin, Matthew C., el al. (2018) Photoactivatable drugs for nicotinic optopharmacology; Nature Methods; Vol. 15; No. 5; 347-350; PMCID PMC5923430; 10.1038/nmeth.4637
• Bavan, Selvan and Patowary, Suparna, el al. (2018) Effects of Chronic Menthol at Alpha3Beta4 (α3β4)-Containing Nicotinic Acetylcholine Receptors; Biophysical Journal; Vol. 114; No. 3; 296A; 10.1016/j.bpj.2017.11.1691
• Muthusamy, Anand K. and Shivange, Amol V., el al. (2018) Microscopy Using Fluorescent Drug Biosensors for "Inside-Out Pharmacology"; Biophysical Journal; Vol. 114; No. 3; 358A; 10.1016/j.bpj.2017.11.1990
• Parker, Rell L. and O'Neill, Heidi C., el al. (2017) Deletion of lynx1 reduces the function of α6* nicotinic receptors; PLoS ONE; Vol. 12; No. 12; Art. No. e0188715; PMCID PMC5716591; 10.1371/journal.pone.0188715
• Henderson, Brandon J. and Wall, Teagan R., el al. (2017) Menthol Enhances Nicotine Reward-Related Behavior by Potentiating Nicotine-Induced Changes in nAChR Function, nAChR Upregulation, and DA Neuron Excitability; Neuropsychopharmacology; Vol. 42; No. 12; 2285-2291; PMCID PMC5645749; 10.1038/npp.2017.72
• Tarren, Josephine R. and Lester, Henry A., el al. (2017) Acute Ethanol Administration Upregulates Synaptic α4-Subunit of Neuronal Nicotinic Acetylcholine Receptors within the Nucleus Accumbens and Amygdala; Frontiers in Molecular Neuroscience; Vol. 10; Art. No. 338; PMCID PMC5660714; 10.3389/fnmol.2017.00338
• Wall, Teagan R. and Henderson, Brandon J., el al. (2017) TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors; Frontiers in Pharmacology; Vol. 8; Art. No. 641; PMCID PMC5626944; 10.3389/fphar.2017.00641
• Shivange, Amol V. and Nichols, Aaron L., el al. (2017) Nicotine in the Endoplasmic Reticulum; Journal of General Physiology; Vol. 149; No. 9; Art. No. 32; 10.1085/jgp.149.9.889
• Mulcahy, Matthew J. and Lester, Henry A. (2017) Granulocytes as models for human protein marker identification following nicotine exposure; Journal of Neurochemistry; Vol. 142; No. S2; 151-161; PMCID PMC6057152; 10.1111/jnc.14010
• Hurtado-Zavala, Joaquin I. and Ramachandran, Binu, el al. (2017) TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus; Nature Communications; Vol. 8; Art. No. 15878; PMCID PMC5524938; 10.1038/ncomms15878
• Post, Michael R. and Lester, Henry A., el al. (2017) Probing for and Quantifying Agonist Hydrogen Bonds in α6β2 Nicotinic Acetylcholine Receptors; Biochemistry; Vol. 56; No. 13; 1836-1840; PMCID PMC6075822; 10.1021/acs.biochem.7b00213
• Mulcahy, Matthew J. and Wang, Jonathan H., el al. (2017) Region specific proteomic analysis of murine brain after chronic nicotine or menthol; FASEB Journal; Vol. 31; No. S1; Art. No. 991.1
• Post, Michael R. and Tender, Gabrielle S., el al. (2017) Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors; eNeuro; Vol. 4; No. 2; Art. No. 0032-17; PMCID PMC5458768; 10.1523/ENEURO.0032-17.2017
• Henley, Beverley M. and Cohen, Bruce N., el al. (2017) Reliable Identification of Living Dopaminergic Neurons in Midbrain Cultures Using RNA Sequencing and TH-promoter-driven eGFP Expression; Journal of Visualized Experiments; No. 120; Art. No. 54981; PMCID PMC5409190; 10.3791/54981
• Kim, Jinho and Henley, Beverley M., el al. (2016) Incubator embedded cell culture imaging system (EmSight) based on Fourier ptychographic microscopy; Biomedical Optics Express; Vol. 7; No. 8; 3097-3110; PMCID PMC4986817; 10.1364/BOE.7.003097
• Nichols, Weston A. and Henderson, Brandon J., el al. (2016) Mutation Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Reduces Low-Sensitivity α4β2, and Increases α5α4β2, Nicotinic Receptor Surface Expression; PLoS ONE; Vol. 11; No. 6; Art. No. e0158032; PMCID PMC4918917; 10.1371/journal.pone.0158032
• Henderson, Brandon J. and Wall, Teagan R., el al. (2016) Menthol Alone Upregulates Midbrain nAChRs, Alters nAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward; Journal of Neuroscience; Vol. 36; No. 10; 2957-2974; PMCID PMC4783498; 10.1523/JNEUROSCI.4194-15.2016
• Post, Michael R. and Dougherty, Dennis A., el al. (2016) Probing Binding Interactions of Agonists with the α6β2 Nicotinic Acetylcholine Receptor; Biophysical Journal; Vol. 110; No. 3; 603A; 10.1016/j.bpj.2015.11.3220
• Patowary, Suparna and Mackey, Elisha D. W., el al. (2016) Effects of Menthol on α3β4∗ Nicotinic Receptors; Biophysical Journal; Vol. 110; No. 3; 603A; 10.1016/j.bpj.2015.11.3221
• Srinivasan, Rahul and Henley, Beverley M., el al. (2016) Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons; Journal of Neuroscience; Vol. 36; No. 1; 65-79; PMCID PMC4701966; 10.1523/JNEUROSCI.2126-15.2016
• Lester, Henry A. and Lavis, Luke D., el al. (2015) Ketamine Inside Neurons?; American Journal of Psychiatry; Vol. 172; No. 11; 1064-1066; PMCID PMC6107348; 10.1176/appi.ajp.2015.14121537
• Post, Michael R. and Limapichat, Walrati, el al. (2015) Heterologous expression and nonsense suppression provide insights into agonist behavior at α6β2 nicotinic acetylcholine receptors; Neuropharmacology; Vol. 97; 376-382; PMCID PMC4635625; 10.1016/j.neuropharm.2015.04.009
• Sinkus, Melissa L. and Graw, Sharon, el al. (2015) The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function; Neuropharmacology; Vol. 96; 274-288; PMCID PMC4486515; 10.1016/j.neuropharm.2015.02.006
• Henderson, Brandon J. and Lester, Henry A. (2015) Inside-out neuropharmacology of nicotinic drugs; Neuropharmacology; Vol. 96; 178-193; PMCID PMC4486611; 10.1016/j.neuropharm.2015.01.022
• Marotta, Christopher B. and Lester, Henry A., el al. (2015) An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7 Nicotinic Acetylcholine Receptors; Chemistry and Biology; Vol. 22; No. 8; 1063-1073; PMCID PMC4547686; 10.1016/j.chembiol.2015.06.018
• Wieskopf, Jeffrey S. and Limapichat, Walrati, el al. (2015) The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors; Science Translational Medicine; Vol. 7; No. 287; Art. No. 287ra72; PMCID PMC5018401; 10.1126/scitranslmed.3009986
• Miles, Timothy F. and Lester, Henry A., el al. (2015) Allosteric activation of the 5-HT_3AB receptor by mCPBG; Neuropharmacology; Vol. 91; 103-108; PMCID PMC4312754; 10.1016/j.neuropharm.2014.12.018
• Xiao, Cheng and Miwa, Julie M., el al. (2015) Nicotinic Receptor Subtype-Selective Circuit Patterns in the Subthalamic Nucleus; Journal of Neuroscience; Vol. 35; No. 9; 3734-3746; PMCID PMC4348180; 10.1523/JNEUROSCI.3528-14.2015
• Nichols, Weston A. and Henderson, Brandon J., el al. (2014) Lynx1 Shifts α4β2 Nicotinic Receptor Subunit Stoichiometry by Affecting Assembly in the Endoplasmic Reticulum; Journal of Biological Chemistry; Vol. 289; No. 45; 31423-31432; PMCID PMC4223341; 10.1074/jbc.M114.573667
• Daeffler, Kristina N.-M. and Lester, Henry A., el al. (2014) Functional Evaluation of Key Interactions Evident in the Structure of the Eukaryotic Cys-Loop Receptor GluCl; ACS Chemical Biology; Vol. 9; No. 10; 2283-2290; PMCID PMC4201344; 10.1021/cb500323d
• Wang, Ying and Xiao, Cheng, el al. (2014) The duplicated α7 subunits assemble and form functional nicotinic receptors with the full-length α7; Journal of Biological Chemistry; Vol. 289; No. 38; 26451-26463; PMCID PMC4176222; 10.1074/jbc.M114.582858
• Limapichat, Walrati and Dougherty, Dennis A., el al. (2014) Subtype-Specific Mechanisms for Functional Interaction between α6β4* Nicotinic Acetylcholine Receptors and P2X Receptors; Molecular Pharmacology; Vol. 86; No. 3; 263-274; PMCID PMC4152909; 10.1124/mol.114.093179
• Kobayashi, Atsuko and Parker, Rell L., el al. (2014) lynx1 Supports Neuronal Health in the Mouse Dorsal Striatum During Aging: an Ultrastructural Investigation; Journal of Molecular Neuroscience; Vol. 53; No. 3; 525-536; PMCID PMC4265479; 10.1007/s12031-014-0352-1
• Shih, Pei-Yu and Engle, Staci E., el al. (2014) Differential Expression and Function of Nicotinic Acetylcholine Receptors in Subdivisions of Medial Habenula; Journal of Neuroscience; Vol. 34; No. 29; 9789-9802; PMCID PMC4099552; 10.1523/JNEUROSCI.0476-14.2014
• Marotta, Christopher B. and Rreza, Iva, el al. (2014) Selective Ligand Behaviors Provide New Insights into Agonist Activation of Nicotinic Acetylcholine Receptors; ACS Chemical Biology; Vol. 9; No. 5; 1153-1159; PMCID PMC4033646; 10.1021/cb400937d
• Srinivasan, Rahul and Henderson, Brandon J., el al. (2014) Pharmacological chaperoning of nAChRs: A therapeutic target for Parkinson's disease; Pharmacological Research; Vol. 83; 20-29; PMCID PMC6075820; 10.1016/j.phrs.2014.02.005
• Lester, Henry and Cohen, Bruce (2014) Drugs and the brain, the MOOC; FASEB Journal; Vol. 28; No. 1; 221.2
• Marotta, Christopher B. and Dilworth, Crystal N., el al. (2014) Probing the non-canonical interface for agonist interaction with an α5 containing nicotinic acetylcholine receptor; Neuropharmacology; Vol. 77; 342-349; PMCID PMC3934363; 10.1016/j.neuropharm.2013.09.028
• Marotta, Christopher and Lester, Henry A., el al. (2014) Identifying Motifs Essential for Selective Activation of Nicotinic Acetylcholine Receptors; Biophysical Journal; Vol. 106; No. 2; 341A; 10.1016/j.bpj.2013.11.1951
• Post, Michael R. and Lester, Henry A., el al. (2014) Structure Function Studies at Two Different Nicotinic Acetylcholine Receptor Subtypes; Biophysical Journal; Vol. 106; No. 2; 341A; 10.1016/j.bpj.2013.11.1950
• Lester, Henry (2014) Drug Actions on Nicotinic Receptors. Chronic vs Acute; Outside-in vs Inside-out; Neuropsychopharmacology; Vol. 39; No. S1; 581-582
• Henderson, Brandon J. and Srinivasan, Rahul, el al. (2013) Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors; Journal of General Physiology; Vol. 143; No. 1; 51-66; PMCID PMC3874574; 10.1085/jgp.201311102
• Henley, Beverley M. and Williams, Brian A., el al. (2013) Transcriptional regulation by nicotine in dopaminergic neurons; Biochemical Pharmacology; Vol. 86; No. 8; 1074-1083; PMCID PMC3969234; 10.1016/j.bcp.2013.07.031
• Miles, Timothy F. and Dougherty, Dennis A., el al. (2013) The 5-HT_3AB Receptor Shows an A_3B_2 Stoichiometry at the Plasma Membrane; Biophysical Journal; Vol. 105; No. 4; 887-898; PMCID PMC3752109; 10.1016/j.bpj.2013.07.015
• Van Arnam, Ethan B. and Blythe, Emily E., el al. (2013) An Unusual Pattern of Ligand-Receptor Interactions for the α7 Nicotinic Acetylcholine Receptor, with Implications for the Binding of Varenicline; Molecular Pharmacology; Vol. 84; No. 2; 201-207; PMCID PMC3716316; 10.1124/mol.113.085795
• Frazier, Shawnalea J. and Cohen, Bruce N., el al. (2013) An Engineered Glutamate-gated Chloride (GluCl) Channel for Sensitive, Consistent Neuronal Silencing by Ivermectin; Journal of Biological Chemistry; Vol. 288; No. 29; 21029-21042; PMCID PMC3774370; 10.1074/jbc.M112.423921
• Chatterjee, Susmita and Santos, Nathan, el al. (2013) The α5 Subunit Regulates the Expression and Function of α4*-Containing Neuronal Nicotinic Acetylcholine Receptors in the Ventral-Tegmental Area; PLoS ONE; Vol. 8; No. 7; Art. No. e68300; PMCID PMC3712017; 10.1371/journal.pone.0068300
• Blum, Angela P. and Van Arnam, Ethan B., el al. (2013) Binding Interactions with the Complementary Subunit of Nicotinic Receptors; Journal of Biological Chemistry; Vol. 288; No. 10; 6991-6997; PMCID PMC3591609; 10.1074/jbc.M112.439968
• Limapichat, Walrati and Yu, Wesley Y., el al. (2013) Key Binding Interactions for Memantine in the NMDA Receptor; ACS Chemical Neuroscience; Vol. 4; No. 2; 255-260; PMCID PMC3751542; 10.1021/cn300180a
• O'Neill, Heidi C. and Laverty, Duncan C., el al. (2013) Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function; Pharmacology Biochemistry and Behavior; Vol. 103; No. 3; 603-621; PMCID PMC3544981; 10.1016/j.pbb.2012.10.014
• Lester, Henry A. and Miwa, Julie M., el al. (2012) Psychiatric Drugs Bind to Classical Targets Within Early Exocytotic Pathways: Therapeutic Effects; Biological Psychiatry; Vol. 72; No. 11; 907-915; PMCID PMC6167061; 10.1016/j.biopsych.2012.05.020
• Miles, Timothy F. and Bower, Kiowa S., el al. (2012) A Coupled Array of Noncovalent Interactions Impacts the Function of the 5‑HT_3A Serotonin Receptor in an Agonist-Specific Way; ACS Chemical Neuroscience; Vol. 3; No. 10; 753-760; PMCID PMC3474281; 10.1021/cn3000586
• Scott, Kimberly M. and Du, Jiangang, el al. (2012) Variability of acute extracellular action potential measurements with multisite silicon probes; Journal of Neuroscience Methods; Vol. 211; No. 1; 22-30; PMCID PMC3473102; 10.1016/j.jneumeth.2012.08.005
• Duffy, Noah H. and Lester, Henry A., el al. (2012) Ondansetron and Granisetron Binding Orientation in the 5‑HT_3 Receptor Determined by Unnatural Amino Acid Mutagenesis; ACS Chemical Biology; Vol. 7; No. 10; 1738-1745; PMCID PMC3477246; 10.1021/cb300246j
• Drenan, Ryan M. and Lester, Henry A. (2012) Insights into the Neurobiology of the Nicotinic Cholinergic System and Nicotine Addiction from Mice Expressing Nicotinic Receptors Harboring Gain-of-Function Mutations; Pharmacological Reviews; Vol. 64; No. 4; 869-879; PMCID PMC3462994; 10.1124/pr.111.004671
• Daeffler, Kristina N.-M. and Lester, Henry A., el al. (2012) Functionally Important Aromatic–Aromatic and Sulfur−π Interactions in the D2 Dopamine Receptor; Journal of the American Chemical Society; Vol. 134; No. 36; 14890-14896; PMCID PMC3461201; 10.1021/ja304560x
• Liu, Cambrian Y. and Xiao, Cheng, el al. (2012) Electrophysiological characterization of Grueneberg ganglion olfactory neurons: spontaneous firing, sodium conductance, and hyperpolarization-activated currents; Journal of Neurophysiology; Vol. 108; No. 5; 1318-1334; 10.1152/jn.00907.2011
• Liu, Cambrian Y. and Xiao, Cheng, el al. (2012) Electrophysiological characterization of Grueneberg ganglion olfactory neurons: spontaneous firing, sodium conductance, and hyperpolarization-activated currents; Journal of Neurophysiology; Vol. 108; No. 5; 1318-1334; PMCID PMC3544954
• Shapiro, Mikhail G. and Frazier, Shawnalea J., el al. (2012) Unparalleled Control of Neural Activity Using Orthogonal Pharmacogenetics; ACS Chemical Neuroscience; Vol. 3; No. 8; 619-629; PMCID PMC3419455; 10.1021/cn300053q
• Miwa, Julie M. and Lester, Henry A., el al. (2012) Optimizing Cholinergic Tone Through Lynx Modulators of Nicotinic Receptors: Implications for Plasticity and Nicotine Addiction; Physiology; Vol. 27; No. 4; 187-199; 10.1152/physiol.00002.2012
• Srinivasan, Rahul and Richards, Christopher I., el al. (2012) Förster Resonance Energy Transfer (FRET) Correlates of Altered Subunit Stoichiometry in Cys-Loop Receptors, Exemplified by Nicotinic α4β2; International Journal of Molecular Sciences; Vol. 13; No. 8; 10022-10040; PMCID PMC3431844; 10.3390/ijms130810022
• Mackey, Elisha D. W. and Engle, Staci E., el al. (2012) α6* Nicotinic Acetylcholine Receptor Expression and Function in a Visual Salience Circuit; Journal of Neuroscience; Vol. 32; No. 30; 10226-10237; PMCID PMC3432940; 10.1523/JNEUROSCI.0007-12.2012
• Tavares, Ximena Da Silva and Blum, Angela P., el al. (2012) Variations in Binding Among Several Agonists at Two Stoichiometries of the Neuronal, α4β2 Nicotinic Receptor; Journal of the American Chemical Society; Vol. 134; No. 28; 11474-11480; PMCID PMC3399941; 10.1021/ja3011379
• Richards, Christopher I. and Luong, Khai, el al. (2012) Live-Cell Imaging of Single Receptor Composition Using Zero-Mode Waveguide Nanostructures; Nano Letters; Vol. 12; No. 7; 3690-3694; PMCID PMC3397148; 10.1021/nl301480h
• Puskar, Nyssa L. and Lester, Henry A., el al. (2012) Probing the Effects of Residues Located Outside the Agonist Binding Site on Drug-Receptor Selectivity in the Nicotinic Receptor; ACS Chemical Biology; Vol. 7; No. 5; 841-846; PMCID PMC3356501; 10.1021/cb200448j
• Srinivasan, Rahul and Richards, Christopher I., el al. (2012) Pharmacological Chaperoning of Nicotinic Acetylcholine Receptors Reduces the Endoplasmic Reticulum Stress Response; Molecular Pharmacology; Vol. 81; No. 6; 759-769; PMCID PMC3362896; 10.1124/mol.112.077792
• Murray, Teresa A. and Bertrand, Daniel, el al. (2012) α7β2 Nicotinic Acetylcholine Receptors Assemble, Function, and Are Activated Primarily via Their α7-α7 Interfaces; Molecular Pharmacology; Vol. 81; No. 2; 175-188; PMCID PMC3263954; 10.1124/mol.111.074088
• Cohen, B. N. and Mackey, E. D. W., el al. (2012) Nicotinic cholinergic mechanisms causing elevated dopamine release and abnormal locomotor behavior; Neuroscience; Vol. 200; 31-41; PMCID PMC3249511; 10.1016/j.neuroscience.2011.10.047
• Xiao, Cheng and Srinivasan, Rahul, el al. (2011) Characterizing functional α6β2 nicotinic acetylcholine receptors in vitro: Mutant β2 subunits improve membrane expression, and fluorescent proteins reveal responsive cells; Biochemical Pharmacology; Vol. 82; No. 8; 852-861; PMCID PMC3162078; 10.1016/j.bcp.2011.05.005
• Du, Jiangang and Blanche, Timothy J., el al. (2011) Multiplexed, High Density Electrophysiology with Nanofabricated Neural Probes; PLoS ONE; Vol. 6; No. 10; Art. No. e26204; PMCID PMC3192171; 10.1371/journal.pone.0026204
• Xu, J. and Cohen, B. N., el al. (2011) Altered activity–rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the β2 nicotinic receptor; Molecular Psychiatry; Vol. 16; No. 10; 1048-1061; PMCID PMC2970689; 10.1038/mp.2010.78
• Van Arnam, Ethan B. and Lester, Henry A., el al. (2011) Dissecting the Functions of Conserved Prolines within Transmembrane Helices of the D2 Dopamine Receptor; ACS Chemical Biology; Vol. 6; No. 10; 1063-1068; PMCID PMC3199346; 10.1021/cb200153g
• Lummis, S. C. R. and Thompson, A. J., el al. (2011) Varenicline Is a Potent Agonist of the Human 5-Hydroxytryptamine_3 Receptor; Journal of Pharmacology and Experimental Therapeutics; Vol. 339; No. 1; 125-131; PMCID PMC3186289; 10.1124/jpet.111.185306
• Blum, Angela P. and Gleitsman, Kristin Rule, el al. (2011) Evidence for an Extended Hydrogen Bond Network in the Binding Site of the Nicotinic Receptor: Role of the Vicinal Disulfide of the α1 Subunit; Journal of Biological Chemistry; Vol. 286; No. 37; 32251-32258; PMCID PMC3173184; 10.1074/jbc.M111.254235
• Richards, Christopher I. and Srinivasan, Rahul, el al. (2011) Trafficking of α4^* Nicotinic Receptors Revealed by Superecliptic Phluorin; Journal of Biological Chemistry; Vol. 286; No. 36; 31241-31249; PMCID PMC3173132; 10.1074/jbc.M111.256024
• Puskar, Nyssa L. and Xiu, Xinan, el al. (2011) Two Neuronal Nicotinic Acetylcholine Receptors, α4β4 and α7, Show Differential Agonist Binding Modes; Journal of Biological Chemistry; Vol. 286; No. 16; 14618-14627; PMCID PMC3077659; 10.1074/jbc.M110.206565
• Miwa, Julie M. and Freedman, Robert, el al. (2011) Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses; Neuron; Vol. 70; No. 1; 20-33; PMCID PMC4418790; 10.1016/j.neuron.2011.03.014
• Pless, Stephan A. and Hanek, Ariele P., el al. (2011) A Cation-π Interaction at a Phenylalanine Residue in the Glycine Receptor Binding Site Is Conserved for Different Agonists; Molecular Pharmacology; Vol. 79; No. 4; 742-748; PMCID PMC3063724; 10.1124/mol.110.069583
• Srinivasan, Rahul and Pantoja, Rigo, el al. (2011) Nicotine up-regulates α4β2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning; Journal of General Physiology; Vol. 137; No. 1; 59-79; PMCID PMC3010053; 10.1085/jgp.201010532
• Thompson, Andrew J. and Lester, Henry A., el al. (2010) The structural basis of function in Cys-loop receptors; Quarterly Reviews of Biophysics; Vol. 43; No. 4; 449-499; 10.1017/S0033583510000168
• Blum, Angela P. and Lester, Henry A., el al. (2010) Nicotinic pharmacophore: The pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH; Proceedings of the National Academy of Sciences of the United States of America; Vol. 107; No. 30; 13206-13211; PMCID PMC2922130; 10.1073/pnas.1007140107
• Drenan, Ryan M. and Grady, Sharon R., el al. (2010) Cholinergic Modulation of Locomotion and Striatal Dopamine Release Is Mediated by α6α4* Nicotinic Acetylcholine Receptors; Journal of Neuroscience; Vol. 30; No. 29; 9877-9889; PMCID PMC3390922; 10.1523/JNEUROSCI.2056-10.2010
• Hanek, Ariele P. and Lester, Henry A., el al. (2010) Photochemical Proteolysis of an Unstructured Linker of the GABAAR Extracellular Domain Prevents GABA but Not Pentobarbital Activation; Molecular Pharmacology; Vol. 78; No. 1; 29-35; PMCID PMC2912059; 10.1124/mol.109.059832
• Grady, Sharon R. and Drenan, Ryan M., el al. (2010) Structural differences determine the relative selectivity of nicotinic compounds for native α4β2^-, α6β2^-, α3β4^*- and α7-nicotine acetylcholine receptors; Neuropharmacology; Vol. 58; No. 7; 1054-1066; PMCID PMC2849849; 10.1016/j.neuropharm.2010.01.013
• Limapichat, Walrati and Lester, Henry A., el al. (2010) Chemical Scale Studies of the Phe-Pro Conserved Motif in the Cys Loop of Cys; Journal of Biological Chemistry; Vol. 285; No. 12; 8976-8984; PMCID PMC2838319; 10.1074/jbc.M109.060939
• Zhao-Shea, Rubing and Cohen, Bruce N., el al. (2010) Dopamine D_2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive 4 nicotinic receptors via a cholinergic-dependent mechanism; FASEB Journal; Vol. 24; No. 1; 49-57; PMCID PMC2797035; 10.1096/fj.09-137034
• Moss, Fraser J. and Imoukhuede, P. I., el al. (2009) GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRET; Journal of General Physiology; Vol. 134; No. 6; 489-521; PMCID PMC2806419; 10.1085/jgp.200910314
• Xiao, Cheng and Nashmi, Raad, el al. (2009) Chronic Nicotine Selectively Enhances α4β2* Nicotinic Acetylcholine Receptors in the Nigrostriatal Dopamine Pathway; Journal of Neuroscience; Vol. 29; No. 40; 12428-12439; PMCID PMC2787412; 10.1523/JNEUROSCI.2939-09.2009
• Pantoja, Rigo and Srinivasan, Rahul, el al. (2009) Pharmacological chaperoning of nicotinic receptors begins in the endoplasmic reticulum: High-resolution imaging; Biochemical Pharmacology; Vol. 78; No. 7; 900-901; 10.1016/j.bcp.2009.06.033
• Srinivasan, Rahul and Pantoja, Rigo, el al. (2009) Pharmacological chaperoning of nicotinic receptors begins in the endoplasmic reticulum: Compartments and stoichiometries; Biochemical Pharmacology; Vol. 78; No. 7; 900; 10.1016/j.bcp.2009.06.032
• Breining, Scott R. and Bencherif, Merouane, el al. (2009) Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the α6 subtype; Bioorganic and Medicinal Chemistry Letters; Vol. 19; No. 15; 4359-4363; PMCID PMC6107347; 10.1016/j.bmcl.2009.05.085
• Torrice, Michael M. and Bower, Kiowa S., el al. (2009) Probing the role of the cation–π interaction in the binding sites of GPCRs using unnatural amino acids; Proceedings of the National Academy of Sciences of the United States of America; Vol. 106; No. 29; 11919-11924; PMCID PMC2715518; 10.1073/pnas.0903260106
• Gleitsman, Kristin R. and Lester, Henry A., el al. (2009) Probing the role of backbone hydrogen bonding in a critical β sheet of the extracellular domain of a cys-loop receptor; ChemBioChem; Vol. 10; No. 8; 1385-1391; PMCID PMC2789490; 10.1002/cbic.200900092
• Son, Cagdas D. and Moss, Fraser J., el al. (2009) Nicotine Normalizes Intracellular Subunit Stoichiometry of Nicotinic Receptors Carrying Mutations Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy; Molecular Pharmacology; Vol. 75; No. 5; 1137-1148; PMCID PMC2672806; 10.1124/mol.108.054494
• Gleitsman, Kristin R. and Shanata, Jai A. P., el al. (2009) Long-Range Coupling in an Allosteric Receptor Revealed by Mutant Cycle Analysis; Biophysical Journal; Vol. 96; No. 8; 3168-3178; PMCID PMC2718292; 10.1016/j.bpj.2008.12.3949
• Imoukhuede, P. I. and Moss, Fraser J., el al. (2009) Ezrin Mediates Tethering of the γ-Aminobutyric Acid Transporter GAT1 to Actin Filaments Via a C-Terminal PDZ-Interacting Domain; Biophysical Journal; Vol. 96; No. 7; 2949-2960; PMCID PMC2711277; 10.1016/j.bpj.2008.11.070
• Xiu, Xinan and Puskar, Nyssa L., el al. (2009) Nicotine binding to brain receptors requires a strong cation–π interaction; Nature; Vol. 458; No. 7237; 534-537; PMCID PMC2755585; 10.1038/nature07768
• Lester, Henry A. and Xiao, Cheng, el al. (2009) Nicotine is a Selective Pharmacological Chaperone of Acetylcholine Receptor Number and Stoichiometry. Implications for Drug Discovery; AAPS Journal; Vol. 11; No. 1; 167-177; PMCID PMC2664890; 10.1208/s12248-009-9090-7
• Bohland, Jason and Wu, Caizhi, el al. (2009) A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale; PLoS Computational Biology; Vol. 5; No. 3; Art. No. e1000334; PMCID PMC2655718; 10.1371/journal.pcbi.1000334
• Pantoja, Rigo and Rodriguez, Erik A., el al. (2009) Single-Molecule Imaging of a Fluorescent Unnatural Amino Acid Incorporated Into Nicotinic Receptors; Biophysical Journal; Vol. 96; No. 1; 226-237; PMCID PMC2710013; 10.1016/j.bpj.2008.09.034
• Gleitsman, Kristin Rule and Kedrowski, Sean M. A., el al. (2008) An intersubunit hydrogen bond in the nicotinic acetylcholine receptor that contributes to channel gating; Journal of Biological Chemistry; Vol. 283; No. 51; 35638-35643; PMCID PMC2602911; 10.1074/jbc.M807226200
• Pless, Stephan A. and Millen, Kat S., el al. (2008) A Cation-π Interaction in the Binding Site of the Glycine Receptor Is Mediated by a Phenylalanine Residue; Journal of Neuroscience; Vol. 28; No. 43; 10937-10942; PMCID PMC2649377; 10.1523/JNEUROSCI.2540-08.2008
• Drenan, Ryan M. and Grady, Sharon R., el al. (2008) In vivo activation of midbrain dopamine neurons via sensitized, high-affinity α6*nicotinic acetylcholine receptors; Neuron; Vol. 60; No. 1; 123-136; PMCID PMC2632732; 10.1016/j.neuron.2008.09.009
• Hanek, Ariele P. and Lester, Henry A., el al. (2008) A Stereochemical Test of a Proposed Structural Feature of the Nicotinic Acetylcholine Receptor; Journal of the American Chemical Society; Vol. 130; No. 40; 13216-13218; 10.1021/ja8015457
• Fonck, Carlos and Nashmi, Raad, el al. (2008) Demonstration of functional α4-containing nicotinic receptors in the medial habenula; Neuropharmacology; Vol. 56; No. 1; 247-253; PMCID PMC2645341; 10.1016/j.neuropharm.2008.08.021
• Price, Kerry L. and Bower, Kiowa S., el al. (2008) A Hydrogen Bond in Loop A Is Critical for the Binding and Function of the 5-HT_3 Receptor; Biochemistry; Vol. 47; No. 24; 6370-6377; PMCID PMC264937; 10.1021/bi800222n
• Maurer, Joshua A. and Elmore, Donald E., el al. (2008) Confirming the Revised C-Terminal Domain of the MscL Crystal Structure; Biophysical Journal; Vol. 94; No. 12; 4662-4667; PMCID PMC2397327; 10.1529/biophysj.107.127365
• Shao, Xuesi M. and Tan, Wenbin, el al. (2008) α4* Nicotinic Receptors in preBotzinger Complex Mediate Cholinergic/Nicotinic Modulation of Respiratory Rhythm; Journal of Neuroscience; Vol. 28; No. 2; 519-528; PMCID PMC3477875; 10.1523/jneurosci.3666-07.2008
• Drenan, Ryan M. and Nashmi, Raad, el al. (2008) Subcellular Trafficking, Pentameric Assembly, and Subunit Stoichiometry of Neuronal Nicotinic Acetylcholine Receptors Containing Fluorescently Labeled α6 and β3 Subunits; Molecular Pharmacology; Vol. 73; No. 1; 27-41; 10.1124/mol.107.039180
• Pless, Stephan A. and Dibas, Mohammed I., el al. (2007) Conformational variability of the glycine receptor M2 domain in response to activation by different agonists; Journal of Biological Chemistry; Vol. 282; No. 49; 36057-36067; 10.1074/jbc.M706468200
• Tapper, Andrew R. and McKinney, Sheri L., el al. (2007) Nicotine responses in hypersensitive and knockout α4 mice account for tolerance to both hypothermia and locomotor suppression in wild-type mice; Physiological Genomics; Vol. 31; No. 3; 422-428; 10.1152/physiolgenomics.00063.2007
• Rodriguez, Erik A. and Lester, Henry A., el al. (2007) Improved amber and opal suppressor tRNAs for incorporation of unnatural amino acids in vivo. Part 1: Minimizing misacylation; RNA; Vol. 13; No. 10; 1703-1714; PMCID PMC1986802; 10.1261/rna.666807
• Rodriguez, Erik A. and Lester, Henry A., el al. (2007) Improved amber and opal suppressor tRNAs for incorporation of unnatural amino acids in vivo. Part 2: Evaluating suppression efficiency; RNA; Vol. 13; No. 10; 1715-1722; PMCID PMC1986817; 10.1261/rna.667607
• Teper, Yaroslav and Whyte, Douglas, el al. (2007) Nicotine-Induced Dystonic Arousal Complex in a Mouse Line Harboring a Human Autosomal-Dominant Nocturnal Frontal Lobe Epilepsy Mutation; Journal of Neuroscience; Vol. 27; No. 38; 10128-10142; PMCID PMC6672658; 10.1523/jneurosci.3042-07.2007
• Wang, Jinti and Lester, Henry A., el al. (2007) Establishing an Ion Pair Interaction in the Homomeric {rho}1 {gamma}-Aminobutyric Acid Type A Receptor That Contributes to the Gating Pathway; Journal of Biological Chemistry; Vol. 282; No. 36; 26210-26216; 10.1074/jbc.M702314200
• Jankowsky, Joanna L. and Younkin, Linda H., el al. (2007) Rodent Aβ Modulates the Solubility and Distribution of Amyloid Deposits in Transgenic Mice; Journal of Biological Chemistry; Vol. 282; No. 31; 22707-22720; PMCID PMC4435736; 10.1074/jbc.M611050200
• Nashmi, Raad and Xiao, Cheng, el al. (2007) Chronic Nicotine Cell Specifically Upregulates Functional α4* Nicotinic Receptors: Basis for Both Tolerance in Midbrain and Enhanced Long-Term Potentiation in Perforant Path; Journal of Neuroscience; Vol. 27; No. 31; 8202-8218; PMCID PMC6673074; 10.1523/jneurosci.2199-07.2007
• Damaj, M. I. and Fonck, C., el al. (2007) Genetic Approaches Identify Differential Roles for α₄β₂* Nicotinic Receptors in Acute Models of Antinociception in Mice; Journal of Pharmacology and Experimental Therapeutics; Vol. 321; No. 3; 1161-1169; 10.1124/jpet.106.112649
• Lerchner, Walter and Xiao, Cheng, el al. (2007) Reversible Silencing of Neuronal Excitability in Behaving Mice by a Genetically Targeted, Ivermectin-Gated Cl^− Channel; Neuron; Vol. 54; No. 1; 35-49; 10.1016/j.neuron.2007.02.030
• Padgett, Claire L. and Hanek, Ariele P., el al. (2007) Unnatural Amino Acid Mutagenesis of the GABA_A Receptor Binding Site Residues Reveals a Novel Cation-π Interaction between GABA and β₂Tyr97; Journal of Neuroscience; Vol. 27; No. 4; 886-892; PMCID PMC2649369; 10.1523/jneurosci.4791-06.2007
• Cashin, Amanda L. and Torrice, Michael M., el al. (2007) Chemical-Scale Studies on the Role of a Conserved Aspartate in Preorganizing the Agonist Binding Site of the Nicotinic Acetylcholine Receptor; Biochemistry; Vol. 46; No. 3; 630-639; PMCID PMC3164877; 10.1021/bi061638b
• Ahern, Christopher A. and Eastwood, Amy L., el al. (2006) A Cation–π Interaction between Extracellular TEA and an Aromatic Residue in Potassium Channels; Journal of General Physiology; Vol. 128; No. 6; 649-657; PMCID PMC2151593; 10.1085/jgp.200609654
• Miwa, Julie M. and Stevens, Tanya R., el al. (2006) The Prototoxin lynx1 Acts on Nicotinic Acetylcholine Receptors to Balance Neuronal Activity and Survival In Vivo; Neuron; Vol. 51; No. 5; 587-600; 10.1016/j.neuron.2006.07.025
• Rodriguez, Erik A. and Lester, Henry A., el al. (2006) In vivo incorporation of multiple unnatural amino acids through nonsense and frameshift suppression; Proceedings of the National Academy of Sciences of the United States of America; Vol. 103; No. 23; 8650-8655; PMCID PMC1482635; 10.1073/pnas.0510817103
• McMenimen, Kathryn A. and Petersson, E. James, el al. (2006) Probing the Mg^(2+) Blockade Site of an N-Methyl-d-aspartate (NMDA) Receptor with Unnatural Amino Acid Mutagenesis; ACS Chemical Biology; Vol. 1; No. 4; 227-234; 10.1021/cb6000944
• Schwarz, Johannes and Schwarz, Sigrid C., el al. (2006) Enhanced expression of hypersensitive α4* nAChR in adult mice increases the loss of midbrain dopaminergic neurons; FASEB Journal; Vol. 20; No. 7; 935-946; 10.1096/fj.05-5497com
• Sokolova, Irina V. and Lester, Henry A., el al. (2006) Postsynaptic Mechanisms Are Essential for Forskolin-Induced Potentiation of Synaptic Transmission; Journal of Neurophysiology; Vol. 95; No. 4; 2570-2579; 10.1152/jn.00617.2005
• Nashmi, Raad and Lester, Henry A. (2006) CNS Localization of Neuronal Nicotinic Receptors; Journal of Molecular Neuroscience; Vol. 30; No. 1-2; 181-184; 10.1385/jmn:30:1:181
• Nashmi, Raad and Lester, Henry A. (2006) CNS Localization of Neuronal Nicotinic Receptors; Journal of Molecular Neuroscience; Vol. 30; No. 1-2; 181-184; 10.1385/JMN:30:1:181
• Xiu, Xinan and Hanek, Ariele P., el al. (2005) A Unified View of the Role of Electrostatic Interactions in Modulating the Gating of Cys Loop Receptors; Journal of Biological Chemistry; Vol. 280; No. 50; 41655-41666; 10.1074/jbc.M508635200
• Fonck, Carlos and Cohen, Bruce N., el al. (2005) Novel Seizure Phenotype and Sleep Disruptions in Knock-In Mice with Hypersensitive α4* Nicotinic Receptors; Journal of Neuroscience; Vol. 25; No. 49; 11396-11411; PMCID PMC6725918; 10.1523/jneurosci.3597-05.2005
• Jankowsky, Joanna L. and Slunt, Hilda H., el al. (2005) Persistent amyloidosis following suppression of Aβ production in a transgenic model of Alzheimer disease; PLoS Medicine; Vol. 2; No. 12; Art. No. e355; PMCID PMC1283364; 10.1371/journal.pmed.0020355
• Lummis, Sarah C. R. and Beene, Darren L., el al. (2005) Cis–trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel; Nature; Vol. 438; No. 4065; 248-252; 10.1038/nature04130
• Lummis, Sarah C. R. and Beene, Darren L., el al. (2005) A Cation-π Binding Interaction with a Tyrosine in the Binding Site of the GABA_C Receptor; Chemistry and Biology; Vol. 12; No. 9; 993-997; 10.1016/j.chembiol.2005.06.012
• Rodrigues-Pinguet, Nivalda O. and Pinguet, Thierry J., el al. (2005) Mutations Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Affect Allosteric Ca²⁺ Activation of the α4β2 Nicotinic Acetylcholine Receptor; Molecular Pharmacology; Vol. 68; No. 2; 487-501; 10.1124/mol.105.011155
• Khakh, Baljit S. and Fisher, James A., el al. (2005) An Angstrom Scale Interaction between Plasma Membrane ATP-Gated P2X₂ and α₄β₂ Nicotinic Channels Measured with Fluorescence Resonance Energy Transfer and Total Internal Reflection Fluorescence Microscopy; Journal of Neuroscience; Vol. 25; No. 29; 6911-6920; PMCID PMC6725363; 10.1523/jneurosci.0561-05.2005
• Chiu, Chi-Sung and Brickley, Stephen, el al. (2005) GABA Transporter Deficiency Causes Tremor, Ataxia, Nervousness, and Increased GABA-Induced Tonic Conductance in Cerebellum; Journal of Neuroscience; Vol. 25; No. 12; 3234-3245; PMCID PMC6725086; 10.1523/jneurosci.3364-04.2005
• Kovoor, Abraham and Seyffarth, Petra, el al. (2005) D₂ Dopamine Receptors Colocalize Regulator of G-Protein Signaling 9-2 (RGS9-2) via the RGS9 DEP Domain, and RGS9 Knock-Out Mice Develop Dyskinesias Associated with Dopamine Pathways; Journal of Neuroscience; Vol. 25; No. 8; 2157-2165; PMCID PMC6726050; 10.1523/jneurosci.2840-04.2005
• Cashin, Amanda L. and Petersson, E. James, el al. (2005) Using Physical Chemistry To Differentiate Nicotinic from Cholinergic Agonists at the Nicotinic Acetylcholine Receptor; Journal of the American Chemical Society; Vol. 127; No. 1; 350-356; 10.1021/ja0461771
• Tapper, Andrew R. and McKinney, Sheri L., el al. (2004) Nicotine Activation of α4* Receptors: Sufficient for Reward, Tolerance, and Sensitization; Science; Vol. 306; No. 5698; 1029-1032; 10.1126/science.1099420
• Diba, Kamran and Lester, Henry A., el al. (2004) Intrinsic Noise in Cultured Hippocampal Neurons: Experiment and Modeling; Journal of Neuroscience; Vol. 24; No. 43; 9723-9733; PMCID PMC6730144; 10.1523/JNEUROSCI.1721-04.2004
• Beene, Darren L. and Price, Kerry L., el al. (2004) Tyrosine Residues That Control Binding and Gating in the 5-Hydroxytryptamine₃ Receptor Revealed by Unnatural Amino Acid Mutagenesis; Journal of Neuroscience; Vol. 24; No. 41; 9097-9104; PMCID PMC6730062; 10.1523/jneurosci.2429-04.2004
• Becker, Christian F. W. and Clayton, Daniel, el al. (2004) On-Resin Assembly of a Linkerless Lanthanide(III)-Based Luminescence Label and Its Application to the Total Synthesis of Site-Specifically Labeled Mechanosensitive Channels; Bioconjugate Chemistry; Vol. 15; No. 5; 1118-1124; 10.1021/bc0498828
• Orb, Sabine and Wieacker, Johannes, el al. (2004) Knockin mice with Leu9′Ser α4-nicotinic receptors: substantia nigra dopaminergic neurons are hypersensitive to agonist and lost postnatally; Physiological Genomics; Vol. 18; No. 3; 299-307; 10.1152/physiolgenomics.00012.2004
• Shapalov, George and Lester, Henry A. (2004) Gating Transitions in Bacterial Ion Channels Measured at 3 µs Resolution; Journal of General Physiology; Vol. 124; No. 2; 151-161; PMCID PMC2229625; 10.1085/jgp.200409087
• Dahan, David S. and Dibas, Mohammed I., el al. (2004) A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site; Proceedings of the National Academy of Sciences of the United States of America; Vol. 101; No. 27; 10195-10200; PMCID PMC454187; 10.1073/pnas.0301885101
• Bhattacharya, Anindya and Dang, Hong, el al. (2004) Uropathic Observations in Mice Expressing a Constitutively Active Point Mutation in the 5-HT_(3A) Receptor Subunit; Journal of Neuroscience; Vol. 24; No. 24; 5537-5548; PMCID PMC6729324; 10.1523/jneurosci.5658-03.2004
• Lester, Henry A. and Dibas, Mohammed I., el al. (2004) Cys-loop receptors: new twists and turns; Trends in Neurosciences; Vol. 27; No. 6; 329-336; 10.1016/j.tins.2004.04.002
• Clayton, Daniel and Shapovalov, George, el al. (2004) Total chemical synthesis and electrophysiological characterization of mechanosensitive channels from Escherichia coli and Mycobacterium tuberculosis; Proceedings of the National Academy of Sciences of the United States of America; Vol. 101; No. 14; 4764-4769; PMCID PMC387322; 10.1073/pnas.0305693101
• Nashmi, Raad and Dickinson, Mary E., el al. (2003) Assembly of α4β2 Nicotinic Acetylcholine Receptors Assessed with Functional Fluorescently Labeled Subunits: Effects of Localization, Trafficking, and Nicotine-Induced Upregulation in Clonal Mammalian Cells and in Cultured Midbrain Neurons; Journal of Neuroscience; Vol. 23; No. 37; 11554-11567; PMCID PMC6740951; 10.1523/jneurosci.23-37-11554.2003
• Gutman, George A. and Lester, Henry A. (2003) International Union of Pharmacology. XLI. Compendium of Voltage-Gated Ion Channels: Potassium Channels; Pharmacological Reviews; Vol. 55; No. 4; 583-586; 10.1124/pr.55.4.9
• Owens, Jeremy C. and Balogh, Seth A., el al. (2003) α4β2* Nicotinic Acetylcholine Receptors Modulate the Effects of Ethanol and Nicotine on the Acoustic Startle Response; Alcoholism: Clinical and Experimental Research; Vol. 27; No. 12; 1867-1875; 10.1097/01.alc.0000102700.72447.0f
• Leite, John F. and Blanton, Michael P., el al. (2003) Conformation-dependent hydrophobic photolabeling of the nicotinic receptor: Electrophysiology-coordinated photochemistry and mass spectrometry; Proceedings of the National Academy of Sciences of the United States of America; Vol. 100; No. 22; 13054-13059; PMCID PMC240743; 10.1073/pnas.2133028100
• Storch, Alexander and Lester, Henry A., el al. (2003) Functional characterization of dopaminergic neurons derived from rodent mesencephalic progenitor cells; Journal of Chemical Neuroanatomy; Vol. 26; No. 2; 133-142; 10.1016/s0891-0618(03)00067-x
• Jensen, Kimmo and Chiu, Chi-Sung, el al. (2003) GABA Transporter-1 (GAT1)-Deficient Mice: Differential Tonic Activation of GABA_A Versus GABA_B Receptors in the Hippocampus; Journal of Neurophysiology; Vol. 90; No. 4; 2690-2701; 10.1152/jn.00240.2003
• Lester, Henry A. and Fonck, Carlos, el al. (2003) Hypersensitive knockin mouse strains identify receptors and pathways for nicotine action; Current opinion in drug discovery & development; Vol. 6; No. 5; 633-639
• Leite, John F. and Dougherty, Dennis A., el al. (2003) Investigation of apparent mass deviations in electrospray ionization tandem mass spectrometry of a benzophenone-labeled peptide; Rapid Communications in Mass Spectrometry; Vol. 17; No. 15; 1677-1684; 10.1002/rcm.1103
• Rodrigues-Pinguet, Nivalda and Jia, Li, el al. (2003) Five ADNFLE Mutations Reduce the Ca²⁺ Dependence of the Mammalian α4β2 Acetylcholine Response; Journal of Physiology; Vol. 550; No. 1; 11-26; PMCID PMC2343021; 10.1113/jphysiol.2003.036681
• Yu, Tzu-ping and Lester, Henry A., el al. (2003) Requirement of a critical period of GABAergic receptor blockade for induction of a cAMP-mediated long-term depression at CA3-CA1 synapses; Synapse; Vol. 49; No. 1; 12-19; 10.1002/syn.10207
• Rahman, Zia and Schwarz, Johannes, el al. (2003) RGS9 Modulates Dopamine Signaling in the Basal Ganglia; Neuron; Vol. 38; No. 6; 941-952; 10.1016/s0896-6273(03)00321-0
• Mu, Ting-Wei and Lester, Henry A., el al. (2003) Different Binding Orientations for the Same Agonist at Homologous Receptors: A Lock and Key or a Simple Wedge?; Journal of the American Chemical Society; Vol. 125; No. 23; 6850-6851; 10.1021/ja0348086
• Beene, Darren L. and Dougherty, Dennis A., el al. (2003) Unnatural amino acid mutagenesis in mapping ion channel function; Current Opinion in Neurobiology; Vol. 13; No. 3; 264-270; 10.1016/s0959-4388(03)00068-0
• Monahan, Sarah L. and Lester, Henry A., el al. (2003) Site-Specific Incorporation of Unnatural Amino Acids into Receptors Expressed in Mammalian Cells; Chemistry and Biology; Vol. 10; No. 6; 573-580; 10.1016/s1074-5521(03)00124-8
• Fonck, Carlos and Nashmi, Raad, el al. (2003) Increased Sensitivity to Agonist-Induced Seizures, Straub Tail, and Hippocampal Theta Rhythm in Knock-In Mice Carrying Hypersensitive α4 Nicotinic Receptors; Journal of Neuroscience; Vol. 23; No. 7; 2582-2590; PMCID PMC6742094; 10.1523/jneurosci.23-07-02582.2003
• Shapovalov, George and Bass, Randal, el al. (2003) Open-State Disulfide Crosslinking between Mycobacterium tuberculosis Mechanosensitive Channel Subunits; Biophysical Journal; Vol. 84; No. 4; 2357-2365; PMCID PMC1302802; 10.1016/S0006-3495(03)75041-3
• Slimko, Eric M. and Lester, Henry A. (2003) Codon optimization of Caenorhabditis elegans GluCl ion channel genes for mammalian cells dramatically improves expression levels; Journal of Neuroscience Methods; Vol. 124; No. 1; 75-81; 10.1016/s0165-0270(02)00362-x
• Rozengurt, Nora and Lopez, Ivan, el al. (2003) Time course of inner ear degeneration and deafness in mice lacking the Kir4.1 potassium channel subunit; Hearing Research; Vol. 177; No. 1-2; 71-80; 10.1016/s0378-5955(02)00799-2
• Leite, John F. and Rodrigues-Pinguet, Nivalda, el al. (2003) Insights into channel function via channel dysfunction; Journal of Clinical Investigation; Vol. 111; No. 4; 436-437; PMCID PMC151932; 10.1172/JCI200317882
• Chiu, Chi-Sung and Jensen, Kimmo, el al. (2002) Number, Density, and Surface/Cytoplasmic Distribution of GABA Transporters at Presynaptic Structures of Knock-In Mice Carrying GABA Transporter Subtype 1–Green Fluorescent Protein Fusions; Journal of Neuroscience; Vol. 22; No. 23; 10251-10266; PMCID PMC6758747; 10.1523/jneurosci.22-23-10251.2002
• Petersson, E. James and Choi, Anita, el al. (2002) A Perturbed pK_a at the Binding Site of the Nicotinic Acetylcholine Receptor: Implications for Nicotine Binding; Journal of the American Chemical Society; Vol. 124; No. 43; 12662-12663; 10.1021/ja028206i
• Li, Ping and Slimko, Eric M., el al. (2002) Selective elimination of glutamate activation and introduction of fluorescent proteins into a Caenorhabditis elegans chloride channel; FEBS Letters; Vol. 528; No. 1-3; 77-82; 10.1016/s0014-5793(02)03245-3
• Slimko, Eric M. and McKinney, Sheri, el al. (2002) Selective Electrical Silencing of Mammalian Neurons In Vitro by the Use of Invertebrate Ligand-Gated Chloride Channels; Journal of Neuroscience; Vol. 22; No. 17; 7373-7379; PMCID PMC6757961; 10.1523/JNEUROSCI.22-17-07373.2002
• Beene, Darren L. and Brandt, Gabriel S., el al. (2002) Cation−π Interactions in Ligand Recognition by Serotonergic (5-HT_(3A)) and Nicotinic Acetylcholine Receptors: The Anomalous Binding Properties of Nicotine; Biochemistry; Vol. 41; No. 32; 10262-10269; 10.1021/bi020266d
• Eickhorst, Angela N. and Berson, Amy, el al. (2002) Control of P2X2 Channel Permeability by the Cytosolic Domain; Journal of General Physiology; Vol. 120; No. 2; 119-131; PMCID PMC2234464; 10.1085/jgp.20028535
• Li, Ming and Lester, Henry A. (2002) Early Fluorescence Signals Detect Transitions at Mammalian Serotonin Transporters; Biophysical Journal; Vol. 83; No. 1; 206-218; PMCID PMC1302140; 10.1016/s0006-3495(02)75162-x
• Nadeau, H. and Lester, H. A. (2002) NRSF Causes cAMP-Sensitive Suppression of Sodium Current in Cultured Hippocampal Neurons; Journal of Neurophysiology; Vol. 88; No. 1; 409-421; 10.1152/jn.2002.88.1.409
• Petersson, E. J. and Shahgholi, M., el al. (2002) MALDI-TOF mass spectrometry methods for evaluation of in vitro aminoacyl tRNA production; RNA; Vol. 8; No. 4; 542-547; PMCID PMC1370275
• Li, Ming and Farley, Robert A., el al. (2002) Voltage-dependent transient currents of human and rat 5-HT transporters (SERT) are blocked by HEPES and ion channel ligands; FEBS Letters; Vol. 513; No. 2-3; 247-252; 10.1016/s0014-5793(02)02322-0
• Kovoor, Abraham and Lester, Henry A. (2002) Gi Irks GIRKs; Neuron; Vol. 33; No. 1; 6-8; 10.1016/s0896-6273(01)00572-4
• Neusch, Clemens and Rozengurt, Nora, el al. (2001) Kir4.1 Potassium Channel Subunit Is Crucial for Oligodendrocyte Development and In Vivo Myelination; Journal of Neuroscience; Vol. 21; No. 15; 5429-5438; PMCID PMC6762664; 10.1523/JNEUROSCI.21-15-05429.2001
• Philipson, Kenneth D. and Gallivan, Justin P., el al. (2001) Incorporation of caged cysteine and caged tyrosine into a transmembrane segment of the nicotinic ACh receptor; American Journal of Physiology. Cell Physiology; Vol. 281; No. 1; C195-C206; 10.1152/ajpcell.2001.281.1.c195
• Li, Ming and Lester, Henry A. (2001) Ion Channel Diseases of the Central Nervous System; CNS Drug Reviews; Vol. 7; No. 2; 214-240; PMCID PMC6741647; 10.1111/j.1527-3458.2001.tb00196.x
• Dougherty, Dennis A. and Lester, Henry A. (2001) Neurobiology: Snails, synapses and smokers; Nature; Vol. 411; No. 6835; 252-254; 10.1038/35077192
• Yu, Tzu-ping and McKinney, Sheri, el al. (2001) gamma-Aminobutyric acid type A receptors modulate cAMP-mediated long-term potentiation and long-term depression at monosynaptic CA3-CA1 synapses; Proceedings of the National Academy of Sciences of the United States of America; Vol. 98; No. 9; 5264-5269; PMCID PMC33198; 10.1073/pnas.091093998
• Khakh, Baljit S. and Smith, W. Bryan, el al. (2001) Activation-dependent changes in receptor distribution and dendritic morphology in hippocampal neurons expressing P2X(2)-green fluorescent protein receptors; Proceedings of the National Academy of Sciences of the United States of America; Vol. 98; No. 9; 5288-5293; PMCID PMC33202; 10.1073/pnas.081089198
• Labarca, Cesar and Schwarz, Johannes, el al. (2001) Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety; Proceedings of the National Academy of Sciences of the United States of America; Vol. 98; No. 5; 2786-2791; PMCID PMC30217; 10.1073/pnas.041582598
• Tong, Yanhe and Brandt, Gabriel S., el al. (2001) Tyrosine decaging leads to substantial membrane trafficking during modulation of an inward rectifier potassium channel; Journal of General Physiology; Vol. 117; No. 2; 103-118; PMCID PMC2217249; 10.1085/jgp.117.2.103
• Chiu, Chi-Sung and Kartalov, Emil, el al. (2001) Single-molecule measurements calibrate green fluorescent protein surface densities on transparent beads for use with 'knock-in' animals and other expression systems; Journal of Neuroscience Methods; Vol. 105; No. 1; 55-63; 10.1016/s0165-0270(00)00354-x
• Li, Lintong and Zhong, Wenge, el al. (2001) The tethered agonist approach to mapping ion channel proteins – toward a structural model for the agonist binding site of the nicotinic acetylcholine receptor; Chemistry and Biology; Vol. 8; No. 1; 47-58; 10.1016/s1074-5521(00)00055-7
• Chiu, Chi-Sung and Ross, Linda S., el al. (2000) The transporter-like protein inebriated mediates hyperosmotic stimuli through intracellular signaling; Journal of Experimental Biology; Vol. 203; No. 23; 3531-3546
• Ehrengruber, Markus U. and Muhlebach, Stephan G., el al. (2000) Modulation of early growth response (EGR) transcription factor-dependent gene expression by using recombinant adenovirus; Gene; Vol. 258; No. 1-2; 63-69; 10.1016/s0378-1119(00)00445-5
• Kofuji, Paulo and Ceelen, Paul, el al. (2000) Genetic Inactivation of an Inwardly Rectifying Potassium Channel (Kir4.1 Subunit) in Mice: Phenotypic Impact in Retina; Journal of Neuroscience; Vol. 20; No. 15; 5733-5740; PMCID PMC2410027; 10.1523/jneurosci.20-15-05733.2000
• Nadeau, H. and Mckinney, S., el al. (2000) ROMK1 (Kir1.1) Causes Apoptosis and Chronic Silencing of Hippocampal Neurons; Journal of Neurophysiology; Vol. 84; No. 2; 1062-1075; 10.1152/jn.2000.84.2.1062
• Khakh, Baljit S. and Zhou, Xiaoping, el al. (2000) State-dependent cross-inhibition between transmitter-gated cation channels; Nature; Vol. 406; No. 6794; 405-410; 10.1038/35019066
• Maurer, Joshua A. and Elmore, Donald E., el al. (2000) Comparing and contrasting Escherichia coli and Mycobacterium tuberculosis mechanosensitive channels (MscL) - New gain of function mutations in the loop region; Journal of Biological Chemistry; Vol. 275; No. 29; 22238-22244; 10.1074/jbc.M003056200
• Nadeau, H. and Lester, H. A. (2000) Two-compartment model for whole-cell data analysis and transient compensation; Journal of Neuroscience Methods; Vol. 99; No. 1-2; 25-35; 10.1016/s0165-0270(00)00210-7
• Dang, Hong and England, Pamela M., el al. (2000) Probing the Role of a Conserved M1 Proline Residue in 5-Hydroxytryptamine₃ Receptor Gating; Molecular Pharmacology; Vol. 57; No. 6; 1114-1122
• Li, Ming and Farley, Robert A., el al. (2000) An Intermediate State of the {gamma}-Aminobutyric Acid Transporter GAT1 Revealed by Simultaneous Voltage Clamp and Fluorescence; Journal of General Physiology; Vol. 115; No. 4; 491-508; PMCID PMC2233755; 10.1085/jgp.115.4.491
• Lester, Henry A. and Karschin, Andreas (2000) Gain of function mutants: Ion channels and G protein-coupled receptors; Annual Review of Neuroscience; Vol. 23; 89-125; 10.1146/annurev.neuro.23.1.89
• Kovoor, Abraham and Chen, Ching-Kang, el al. (2000) Co-expression of Gbeta 5 Enhances the Function of Two Ggamma Subunit-like Domain-containing Regulators of G Protein Signaling Proteins; Journal of Biological Chemistry; Vol. 275; No. 5; 3397-3402
• Ivanina, Tatiana and Neusch, Clemens, el al. (2000) Expression of GIRK (Kir3.1/Kir3.4) channels in mouse fibroblast cells with and without β1 integrins; FEBS Letters; Vol. 466; No. 2-3; 327-332; 10.1016/s0014-5793(99)01738-x
• Unger, M. and Kartalov, E., el al. (1999) Single-Molecule Fluorescence Observed with Mercury Lamp Illumination; BioTechniques; Vol. 27; No. 5; 1008-1014; 10.2144/99275rr01
• England, Pamela M. and Lester, Henry A., el al. (1999) Mapping Disulfide Connectivity Using Backbone Ester Hydrolysis; Biochemistry; Vol. 38; No. 43; 14409-14415; 10.1021/bi991424c
• Khakh, Baljit S. and Proctor, William R., el al. (1999) Allosteric Control of Gating and Kinetics at P2X₄ Receptor Channels; Journal of Neuroscience; Vol. 19; No. 17; 7289-7299; PMCID PMC6782529; 10.1523/jneurosci.19-17-07289.1999
• Khakh, Baljit S. and Lester, Henry A. (1999) Dynamic Selectivity Filters in Ion Channels; Neuron; Vol. 23; No. 4; 653-658; 10.1016/s0896-6273(01)80025-8
• Li, Jun and Lester, Henry A. (1999) Single-channel kinetics of the rat olfactory cyclic nucleotide-gated channel expressed in Xenopus oocytes; Molecular Pharmacology; Vol. 55; No. 5; 883-893
• Li, Jun and Lester, Henry A. (1999) Functional roles of aromatic residues in the ligand-binding domain of cyclic nucleotide-gated channels; Molecular Pharmacology; Vol. 55; No. 5; 873-882
• Khakh, Baljit S. and Bao, Xiaoyan R., el al. (1999) Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds; Nature Neuroscience; Vol. 2; No. 4; 322-330; 10.1038/7233
• England, Pamela M. and Zhang, Yinong, el al. (1999) Backbone Mutations in Transmembrane Domains of a Ligand-Gated Ion Channel: Implications for the Mechanism of Gating; Cell; Vol. 96; No. 1; 89-98; 10.1016/s0092-8674(00)80962-9
• McPhee, Jancy C. and Dang, Yan L., el al. (1998) Evidence for a Functional Interaction between Integrins and G Protein-activated Inward Rectifier K+ Channels; Journal of Biological Chemistry; Vol. 273; No. 52; 34696-34702
• Li, Yong-Xin and Zhang, Yinong, el al. (1998) Enhancement of Neurotransmitter Release Induced by Brain-Derived Neurotrophic Factor in Cultured Hippocampal Neurons; Journal of Neuroscience; Vol. 18; No. 24; 10231-10240; PMCID PMC6793341; 10.1523/jneurosci.18-24-10231.1998
• Zhong, Wenge and Gallivan, Justin P., el al. (1998) From ab initio quantum mechanics to molecular neurobiology: A cation-pi binding site in the nicotinic receptor; Proceedings of the National Academy of Sciences of the United States of America; Vol. 95; No. 21; 12088-12093; PMCID PMC22789; 10.1073/pnas.95.21.12088
• Cao, Yongwei and Li, Ming, el al. (1998) Amino Acid Residues that Control pH Modulation of Transport-Associated Current in Mammalian Serotonin Transporters; Journal of Neuroscience; Vol. 18; No. 19; 7739-7749; PMCID PMC6793029; 10.1523/jneurosci.18-19-07739.1998
• Dougherty, Dennis A. and Lester, Henry A. (1998) The Crystal Structure of a Potassium Channel — A New Era in the Chemistry of Biological Signaling; Angewandte Chemie International Edition; Vol. 37; No. 17; 2329-2331; 10.1002/(SICI)1521-3773(19980918)37:17<2329::AID-ANIE2329>3.0.CO;2-M
• Li, Yong-Xin and Xu, Youfeng, el al. (1998) Expression of a dominant negative TrkB receptor, T1, reveals a requirement for presynaptic signaling in BDNF-induced synaptic potentiation in cultured hippocampal neurons; Proceedings of the National Academy of Sciences of the United States of America; Vol. 95; No. 18; 10884-10889; PMCID PMC27990
• Silverman, Scott K. and Lester, Henry A., el al. (1998) Asymmetrical Contributions of Subunit Pore Regions to Ion Selectivity in an Inward Rectifier K⁺ Channel; Biophysical Journal; Vol. 75; No. 3; 1330-1339; PMCID PMC1299807; 10.1016/s0006-3495(98)74051-2
• Miller, Jeffrey C. and Silverman, Scott K., el al. (1998) Flash Decaging of Tyrosine Sidechains in an Ion Channel; Neuron; Vol. 20; No. 4; 619-624; 10.1016/s0896-6273(00)81001-6
• Lester, Henry A. and Dougherty, Dennis A. (1998) New Views of Multi-Ion Channels; Journal of General Physiology; Vol. 111; No. 2; 181-183; PMCID PMC2222761; 10.1085/jgp.111.2.181
• West, Anthony P., Jr. and Bjorkman, Pamela J., el al. (1997) Expression and Circular Dichroism Studies of the Extracellular Domain of the alpha Subunit of the Nicotinic Acetylcholine Receptor; Journal of Biological Chemistry; Vol. 272; No. 41; 25468-25473; 10.1074/jbc.272.41.25468
• Gallivan, Justin P. and Lester, Henry A., el al. (1997) Site-specific incorporation of biotinylated amino acids to identify surface-exposed residues in integral membrane proteins; Chemistry and Biology; Vol. 4; No. 10; 739-749; 10.1016/s1074-5521(97)90312-4
• England, Pamela M. and Lester, Henry A., el al. (1997) Site-specific, photochemical proteolysis applied to ion channels in vivo; Proceedings of the National Academy of Sciences of the United States of America; Vol. 94; No. 20; 11025-11030; PMCID PMC23572; 10.1073/pnas.94.20.11025
• Doupnik, Craig A. and Davidson, Norman, el al. (1997) RGS proteins reconstitute the rapid gating kinetics of Gβγ-activated inwardly rectifying K^+ channels; Proceedings of the National Academy of Sciences of the United States of America; Vol. 94; No. 19; 10461-10466; PMCID PMC23385
• Ehrengruber, Markus U. and Doupnik, Craig A., el al. (1997) Activation of heteromeric G protein-gated inward rectifier K+ channels overexpressed by adenovirus gene transfer inhibits the excitability of hippocampal neurons; Proceedings of the National Academy of Sciences of the United States of America; Vol. 94; No. 13; 7070-7075; PMCID PMC21286
• Quick, Michael W. and Corey, Janis L., el al. (1997) Second Messengers, Trafficking-Related Proteins, and Amino Acid Residues that Contribute to the Functional Regulation of the Rat Brain GABA Transporter GAT1; Journal of Neuroscience; Vol. 17; No. 9; 2967-2979; PMCID PMC6573650; 10.1523/jneurosci.17-09-02967.1997
• Li, Jun and Zagotta, William N., el al. (1997) Cyclic nucleotide-gated channels: structural basis of ligand efficacy and allosteric modulation; Quarterly Reviews of Biophysics; Vol. 30; No. 2; 177-193
• Cao, Yongwei and Mager, Sela, el al. (1997) H⁺ Permeation and pH Regulation at a Mammalian Serotonin Transporter; Journal of Neuroscience; Vol. 17; No. 7; 2257-2266; PMCID PMC6573487; 10.1523/jneurosci.17-07-02257.1997
• Bradley, Jonathan and Zhang, Yinong, el al. (1997) Functional Expression of the Heteromeric "Olfactory" Cyclic Nucleotide-Gated Channel in the Hippocampus: A Potential Effector of Synaptic Plasticity in Brain Neurons; Journal of Neuroscience; Vol. 17; No. 6; 1993-2005; PMCID PMC6793760; 10.1523/JNEUROSCI.17-06-01993.1997
• Silverman, Scott K. and Kofuji, Paulo, el al. (1996) A regenerative link in the ionic fluxes through the weaver potassium channel underlies the pathophysiology of the mutation; Proceedings of the National Academy of Sciences of the United States of America; Vol. 93; No. 26; 15429-15434; PMCID PMC26421; 10.1073/pnas.93.26.15429
• Quick, Michael W. and Lester, Henry A., el al. (1996) Desensitization of Inositol 1,4,5-Trisphosphate/Ca2+-induced Cl- Currents by Prolonged Activation of G Proteins in Xenopus Oocytes; Journal of Biological Chemistry; Vol. 271; No. 50; 32021-32027
• Kearney, Patrick C. and Zhang, Haiyun, el al. (1996) Determinants of Nicotinic Receptor Gating in Natural and Unnatural Side Chain Structures at the M2 9′ Position; Neuron; Vol. 17; No. 6; 1221-1229; 10.1016/s0896-6273(00)80252-4
• Silverman, Scott K. and Lester, Henry A., el al. (1996) Subunit Stoichiometry of a Heteromultimeric G protein-coupled Inward-rectifier K^+ Channel; Journal of Biological Chemistry; Vol. 271; No. 48; 30524-30528; 10.1074/jbc.271.48.30524
• Kearney, Patrick C. and Nowak, Mark W., el al. (1996) Dose-response relations for unnatural amino acids at the agonist binding site of the nicotinic acetylcholine receptor: tests with novel side chains and with several agonists; Molecular Pharmacology; Vol. 50; No. 5; 1401-1412
• Saks, Margaret E. and Sampson, Jeffrey R., el al. (1996) An engineered Tetrahymena tRNA(Gln) for in vivo incorporation of unnatural amino acids into proteins by nonsense suppression; Journal of Biological Chemistry; Vol. 271; No. 38; 23169-23175
• Mager, Sela and Kleinberger-Doron, Nurit, el al. (1996) Ion Binding and Permeation at the GABA Transporter GAT1; Journal of Neuroscience; Vol. 16; No. 17; 5405-5414; PMCID PMC6578888; 10.1523/jneurosci.16-17-05405.1996
• Schreibmayer, Wolfgang and Dessauer, Carmen W., el al. (1996) Inhibition of an inwardly rectifying K^+ channel by G-protein ɑ-subunits; Nature; Vol. 380; No. 6575; 624-627; 10.1038/380624a0
• Figl, Antonio and Labarca, Cesar, el al. (1996) Voltage-Jump Relaxation Kinetics for Wild-type and Chimeric β Subunits of Neuronal Nicotinic Receptors; Journal of General Physiology; Vol. 107; No. 3; 369-379; PMCID PMC2216994; 10.1085/jgp.107.3.369
• Su, Alyce and Mager, Sela, el al. (1996) A multi-substrate single-file model for ion-coupled transporters; Biophysical Journal; Vol. 70; No. 2; 762-777; PMCID PMC1224976; 10.1016/S0006-3495(96)79616-9
• Labarca, Cesar and Nowak, Mark W., el al. (1995) Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors; Nature; Vol. 376; No. 6540; 514-516; 10.1038/376514a0
• Dascal, Nathan and Doupnik, Craig A., el al. (1995) Inhibition of function in Xenopus oocytes of the inwardly rectifying G-protein-activated atrial K channel (GIRK1) by overexpression of a membrane-attached form of the C-terminal tail; Proceedings of the National Academy of Sciences of the United States of America; Vol. 92; No. 15; 6758-6762; PMCID PMC41408; 10.1073/pnas.92.15.6758
• Kofuji, Paulo and Davidson, Norman, el al. (1995) Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by Gβγ subunits and function as heteromultimers; Proceedings of the National Academy of Sciences of the United States of America; Vol. 92; No. 14; 6542-6546; PMCID PMC41554; 10.1073/pnas.92.14.6542
• Doupnik, Craig A. and Lim, Nancy F., el al. (1995) Intrinsic Gating Properties of a Cloned G Protein-activated Inward Rectifier K^+ Channel; Journal of General Physiology; Vol. 106; No. 1; 1-23; PMCID PMC2229253; 10.1085/jgp.106.1.1
• Cohen, B. N. and Figl, A., el al. (1995) Regions of beta 2 and beta 4 responsible for differences between the steady state dose-response relationships of the alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors; Journal of General Physiology; Vol. 105; No. 6; 745-764; PMCID PMC2216958; 10.1085/jgp.107.3.369
• Nowak, Mark W. and Kearney, Patrick C., el al. (1995) Nicotinic Receptor Binding Site Probed with Unnatural Amino Acid Incorporation in Intact Cells; Science; Vol. 268; No. 5209; 439-442; 10.1126/science.7716551
• Lim, Nancy Fidler and Dascal, Nathan, el al. (1995) A G protein-gated K channel is activated via beta 2-adrenergic receptors and G beta gamma subunits in Xenopus oocytes; Journal of General Physiology; Vol. 105; No. 3; 421-439; PMCID PMC2216943; 10.1085/jgp.105.3.421
• Quick, Michael W. and Simon, Melvin I., el al. (1994) Differential coupling of G protein alpha subunits to seven-helix receptors expressed in Xenopus oocytes; Journal of Biological Chemistry; Vol. 269; No. 48; 30164-30172
• Bradley, Jonathan and Li, Jun, el al. (1994) Heteromeric olfactory cyclic nucleotide-gated channels: a subunit that confers increased sensitivity to cAMP; Proceedings of the National Academy of Sciences of the United States of America; Vol. 91; No. 19; 8890-8894; PMCID PMC44712
• Karschin, Christine and Schreibmayer, Wolfgang, el al. (1994) Distribution and localization of a G protein-coupled inwardly rectifying K⁺ channel in the rat; FEBS Letters; Vol. 348; No. 2; 139-144; 10.1016/0014-5793(94)00590-7
• Corey, Janis L. and Davidson, Norman, el al. (1994) Protein kinase C modulates the activity of a cloned gamma-aminobutyric acid transporter expressed in Xenopus oocytes via regulated subcellular redistribution of the transporter; Journal of Biological Chemistry; Vol. 269; No. 20; 14759-14767
• Lester, Henry A. and Mager, Sela, el al. (1994) Permeation Properties of Neurotransmitter Transporters; Annual Review of Pharmacology and Toxicology; Vol. 34; 219-249; 10.1146/annurev.pharmtox.34.1.219
• Corey, Janis L. and Quick, Michael W., el al. (1994) A cocaine-sensitive Drosophila serotonin transporter: Cloning, expression, and electrophysiological characterization; Proceedings of the National Academy of Sciences of the United States of America; Vol. 91; No. 3; 1188-1192; PMCID PMC521479
• Dascal, Nathan and Schreibmayer, Wolfgang, el al. (1993) Atrial G protein-activated K+ channel: expression cloning and molecular properties; Proceedings of the National Academy of Sciences of the United States of America; Vol. 90; No. 21; 10235-10239; PMCID PMC47749; 10.1073/pnas.90.21.10235
• Slepak, Vladlen Z. and Quick, Michael W., el al. (1993) Random Mutagenesis of G protein ɑ Subunit G_oɑ. Mutations altering nucleotide binding; Journal of Biological Chemistry; Vol. 268; No. 29; 21889-21894
• Lester, Henry A. and Dascal, Nathan (1993) The response to vagusstoff; Nature; Vol. 364; No. 6440; 758-759; 10.1038/364758a0
• Dascal, Nathan and Lim, Nancy F., el al. (1993) Expression of an atrial G-protein-activated potassium channel in Xenopus oocytes; Proceedings of the National Academy of Sciences of the United States of America; Vol. 90; No. 14; 6596-6600; PMCID PMC46979; 10.1073/pnas.90.14.6596
• McCarthy, N. A. and McDonough, S., el al. (1993) Voltage-dependent Block of the Cystic Fibrosis Transmembrane Conductance Regulator Cl- Channel by Two Closely Related Arylaminobenzoates; Journal of General Physiology; Vol. 102; No. 1; 1-23; PMCID PMC2229162; 10.1085/jgp.102.1.1
• Uezono, Y. and Bradley, J., el al. (1993) Receptors that couple to 2 classes of G proteins increase cAMP and activate CFTR expressed in Xenopus oocytes; Receptors & Channels; Vol. 1; No. 3; 233-241
• Cohen, Bruce N. and Labarca, Cesar, el al. (1992) Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations; Journal of General Physiology; Vol. 100; No. 3; 373-400; PMCID PMC2229089; 10.1085/jgp.100.3.373
• Guastella, John and Brecha, Nicholas, el al. (1992) Cloning, expression, and localization of a rat brain high-affinity glycine transporter; Proceedings of the National Academy of Sciences of the United States of America; Vol. 89; No. 15; 7189-7193; PMCID PMC49671; 10.1073/pnas.89.15.7189
• Lester, Henry A. (1992) The Permeation Pathway of Neurotransmitter-Gated Ion Channels; Annual Review of Biophysics and Biomolecular Structure; Vol. 21; 267-292; 10.1146/annurev.bb.21.060192.001411
• Cohen, Bruce N. and Labarca, Cesar, el al. (1992) Tris+/Na+ permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region; Journal of General Physiology; Vol. 99; No. 4; 545-572; PMCID PMC2219204; 10.1085/jgp.99.4.545
• Yang, Xian-cheng and Labarca, Cesar, el al. (1992) Cell-specific posttranslational events affect functional expression at the plasma membrane but not tetrodotoxin sensitivity of the rat brain IIA sodium channel α-subunit expressed in mammalian cells; Journal of Neuroscience; Vol. 12; No. 1; 268-277; PMCID PMC6575683; 10.1523/jneurosci.12-01-00268.1992
• Lester, Henry A. (1991) Strategies for studying permeation at voltage-gated ion channels; Annual Review of Physiology; Vol. 53; 477-496
• Walter, A. E. and Hoger, J. H., el al. (1991) Low Molecular Weight mRNA Encodes a Protein That Controls Serotonin 5-HT_(1c) and Acetylcholine M_1 Receptor Sensitivity in Xenopus Oocytes; Journal of General Physiology; Vol. 98; No. 2; 399-417; PMCID PMC2229050; 10.1085/jgp.98.2.399
• Karschin, Andreas and Ho, Begonia Y., el al. (1991) Heterologously expressed serotonin 1A receptors couple to muscarinic K+ channels in heart; Proceedings of the National Academy of Sciences of the United States of America; Vol. 88; No. 13; 5694-5698; PMCID PMC51944; 10.1073/pnas.88.13.5694
• Ahmed, C. M. lqbal and Auld, Vanessa J., el al. (1990) Both sodium channel II and IIA alpha subunits are expressed in rat brain; Nucleic Acids Research; Vol. 18; No. 19; 5907-5907; PMCID PMC332354; 10.1093/nar/18.19.5907
• Krafte, Douglas S. and Goldin, Alan L., el al. (1990) Inactivation of cloned Na channels expressed in Xenopus oocytes; Journal of General Physiology; Vol. 96; No. 4; 689-706; PMCID PMC2229013; 10.1085/jgp.96.4.689
• Guastella, John and Nelson, Nathan, el al. (1990) Cloning and expression of a rat brain GABA transporter; Science; Vol. 249; No. 4974; 1303-1306; 10.1126/science.1975955
• Snutch, Terry P. and Leonard, John P., el al. (1990) Rat brain expresses a heterogeneous family of calcium channels; Proceedings of the National Academy of Sciences of the United States of America; Vol. 87; No. 9; 3391-3395; PMCID PMC53906; 10.1073/pnas.87.9.3391
• Auld, V. J. and Goldin, A. L., el al. (1990) A Neutral Amino Acid Change in Segment IIS4 Dramatically Alters the Gating Properties of the Voltage-Dependent Sodium Channel; Proceedings of the National Academy of Sciences of the United States of America; Vol. 87; No. 1; 323-327; PMCID PMC53255
• Charnet, Pierre and Labarca, Cesar, el al. (1990) An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor; Neuron; Vol. 4; No. 1; 87-95; 10.1016/0896-6273(90)90445-L
• Yu, Lei and Blumer, Kendall J., el al. (1989) Functional expression of the yeast alpha-factor receptor in Xenopus oocytes; Journal of Biological Chemistry; Vol. 264; No. 35; 20847-20850
• Leonard, R. J. and Karschin, A., el al. (1989) Expression of Drosophila Shaker potassium channels in mammalian cells infected with recombinant vaccinia virus; Proceedings of the National Academy of Sciences of the United States of America; Vol. 86; No. 19; 7629-7633; PMCID PMC298120
• Lester, Henry A. and Snutch, Terry P., el al. (1989) Expression of mRNA Encoding Voltage-Dependent Ca Channels in Xenopus Oocytes: Review and Progress Report; Annals of the New York Academy of Sciences; Vol. 560; 174-182; 10.1111/j.1749-6632.1989.tb24094.x
• Krafte, Douglas S. and Lester, Henry A. (1989) Expression of functional sodium channels in stage II–III Xenopus oocytes; Journal of Neuroscience Methods; Vol. 26; No. 3; 211-215; 10.1016/0165-0270(89)90118-0
• Fong, Tung Ming and Davidson, Norman, el al. (1989) Further evidence demonstrating that N-methyl-D-aspartate and kainate activate distinct ion channels; Synapse; Vol. 4; No. 1; 88-95; 10.1002/syn.890040110
• Leonard, Reid J. and Labarca, Cesar G., el al. (1988) Evidence that the M2 membrane-spanning region lines the ion channel pore of the nicotinic receptor; Science; Vol. 242; No. 4885; 1578-1581; 10.1126/science.2462281
• Rudy, Bernardo and Hoger, Jeff H., el al. (1988) At least two mRNA species contribute to the properties of rat brain A-type potassium channel expressed in xenopus oocytes; Neuron; Vol. 1; No. 8; 649-658; 10.1016/0896-6273(88)90164-x
• Lester, Henry A. (1988) Heterologous Expression of Excitability Proteins: Route to More Specific Drugs?; Science; Vol. 241; No. 4869; 1057-1063; 10.1126/science.2457947
• Krafte, Douglas S. and Snutch, Terry P., el al. (1988) Evidence for the involvement of more than one mRNA species in controlling the inactivation process of rat and rabbit brain Na channels expressed in Xenopus oocytes; Journal of Neuroscience; Vol. 8; No. 8; 2859-2868; PMCID PMC6569391; 10.1523/jneurosci.08-08-02859.1988
• Iverson, L. E. and Tanouye, M. A., el al. (1988) A-Type Potassium Channels Expressed from Shaker Locus cDNA; Proceedings of the National Academy of Sciences of the United States of America; Vol. 85; No. 15; 5723-5727; PMCID PMC281833
• Auld, Vanessa J. and Goldin, Alan L., el al. (1988) A rat brain Na⁺ channel α subunit with novel gating properties; Neuron; Vol. 1; No. 6; 449-461; 10.1016/0896-6273(88)90176-6
• Sutton, Fedora and Davidson, Norman, el al. (1988) Tetrodotoxin-sensitive voltage-dependent Na currents recorded from Xenopus oocytes injected with mammalian cardiac muscle RNA; Molecular Brain Research; Vol. 3; No. 2; 187-191; 10.1016/0169-328x(88)90065-4
• Fong, Tung Ming and Davidson, Norman, el al. (1988) Properties of two classes of rat brain acidic amino acid receptors induced by distinct mRNA populations in Xenopus oocytes; Synapse; Vol. 2; No. 6; 657-665; 10.1002/syn.890020613
• Yoshii, Kiyonori and Yu, Lei, el al. (1987) Equilibrium Properties of Mouse-Torpedo Acetylcholine Receptor Hybrids Expressed in Xenopus Oocytes; Journal of General Physiology; Vol. 90; No. 4; 553-573; PMCID PMC2228871; 10.1085/jgp.90.4.553
• Mayne, Katharine Mixter and Yoshii, Kiyonori, el al. (1987) Expression of mouse-Torpedo acetylcholine receptor subunit chimeras and hybrids in Xenopus oocytes; Molecular Brain Research; Vol. 2; No. 3; 191-197; 10.1016/0169-328x(87)90026-x
• Lübbert, Hermann and Hoffman, Beth J., el al. (1987) cDNA Cloning of a Serotonin 5-HT1C Receptor by Electrophysiological Assays of mRNA-Injected Xenopus Oocytes; Proceedings of the National Academy of Sciences of the United States of America; Vol. 84; No. 12; 4332-4336; PMCID PMC305079
• Gurney, Alison M. and Tsien, Roger Y., el al. (1987) Activation of a Potassium Current by Rapid Photochemically Generated Step Increases of Intracellular Calcium in Rat Sympathetic Neurons; Proceedings of the National Academy of Sciences of the United States of America; Vol. 84; No. 10; 3496-3500; PMCID PMC304898
• Gurney, Alison M. and Lester, Henry A. (1987) Light-flash physiology with synthetic photosensitive compounds; Physiological Reviews; Vol. 67; No. 2; 583-617; 10.1152/physrev.1987.67.2.583
• Lübbert, Hermann and Snutch, Terry P., el al. (1987) Rat brain 5-HT_(1C) receptors are encoded by a 5-6 kbase mRNA size class and are functionally expressed in injected Xenopus oocytes; Journal of Neuroscience; Vol. 7; No. 4; 1159-1165; PMCID PMC6569006; 10.1523/jneurosci.07-04-01159.1987
• Leonard, John P. and Nargeot, Joël, el al. (1987) Ca channels induced in Xenopus oocytes by rat brain mRNA; Journal of Neuroscience; Vol. 7; No. 3; 875-881; PMCID PMC6569056; 10.1523/jneurosci.07-03-00875.1987
• Snutch, Terry P. and Leonard, John P., el al. (1987) Characterization of voltage-gated calcium channels in Xenopus oocytes after injection of RNA from electrically excitable tissues; Society of General Physiologists series; Vol. 42; 153-166
• Dascal, Nathan and Ifune, Catherine, el al. (1986) Involvement of a GTP-binding protein in mediation of serotonin and acetylcholine responses in Xenopus oocytes injected with rat brain messenger RNA; Molecular Brain Research; Vol. 1; No. 3; 201-209; 10.1016/0169-328x(86)90026-4
• Goldin, Alan L. and Snutch, Terry P., el al. (1986) Messenger RNA coding for only the alpha subunit of the rat brain Na channel is sufficient for expression of functional channels in Xenopus oocytes; Proceedings of the National Academy of Sciences of the United States of America; Vol. 83; No. 19; 7503-7507; PMCID PMC386747
• Chabala, Lee D. and Lester, Henry A. (1986) Activation of acetylcholine receptor channels by covalently bound agonists in cultured rat myoballs; Journal of Physiology; Vol. 379; No. 1; 83-108; PMCID PMC1182886; 10.1113/jphysiol.1986.sp016242
• Dascal, Nathan and Snutch, Terry P., el al. (1986) Expression and modulation of voltage-gated calcium channels after RNA injection in Xenopus oocytes; Science; Vol. 231; No. 4742; 1147-1150; 10.1126/science.2418503
• Chabala, Lee D. and Gurney, Alison M., el al. (1986) Dose-response of acetylcholine receptor channels opened by a flash-activated agonist in voltage-clamped rat myoballs; Journal of Physiology; Vol. 371; No. 1; 407-433; PMCID PMC1192732; 10.1113/jphysiol.1986.sp015983
• Dascal, Nathan and Lotan, Ilana, el al. (1985) Acetylcholine and phorbol esters inhibit potassium currents evoked by adenosine and cAMP in Xenopus oocytes; Proceedings of the National Academy of Sciences of the United States of America; Vol. 82; No. 17; 6001-6005; PMCID PMC390682
• Gurney, Alison M. and Nerbonne, Jeanne M., el al. (1985) Photoinduced Removal of Nifedipine Reveals Mechanisms of Calcium Antagonist Action on Single Heart Cells; Journal of General Physiology; Vol. 86; No. 3; 353-379; PMCID PMC2228798; 10.1085/jgp.86.3.353
• Krouse, Mauri E. and Lester, Henry A., el al. (1985) Rates and Equilibria for a Photoisomerizable Antagonist at the Acetylcholine Receptor of Electrophorus Electroplaques; Journal of General Physiology; Vol. 86; No. 2; 235-256; PMCID PMC2228782; 10.1085/jgp.86.2.235
• Chabala, Lee D. and Gurney, Alison M., el al. (1985) Photoactivation and dissociation of agonist molecules at the nicotinic acetylcholine receptor in voltage-clamped rat myoballs; Biophysical Journal; Vol. 48; No. 2; 241-246; PMCID PMC1329315; 10.1016/s0006-3495(85)83777-2
• White, Michael M. and Mayne, Katharine Mixter, el al. (1985) Mouse-Torpedo Hybrid Acetylcholine Receptors: Functional Homology Does not Equal Sequence Homology; Proceedings of the National Academy of Sciences of the United States of America; Vol. 82; No. 14; 4852-4856; PMCID PMC391003
• Richard, Sylvain and Nerbonne, Jeanne M., el al. (1985) Photochemically produced intracellular concentration jumps of cAMP mimic the effects of catecholamines on excitation-contraction coupling in frog atrial fibers; Pflügers Archiv European Journal of Physiology; Vol. 403; No. 3; 312-317; 10.1007/bf00583606
• Kegel, Daniel R. and Wolf, Benjamin D., el al. (1985) Software for electrophysiological experiments with a personal computer; Journal of Neuroscience Methods; Vol. 12; No. 4; 317-330; 10.1016/0165-0270(85)90016-0
• Nerbonne, Jeanne M. and Richard, Sylvain, el al. (1984) New photoactivatable cyclic nucleotides produce intracellular jumps in cyclic AMP and cyclic GMP concentrations; Nature; Vol. 310; No. 5972; 74-76; 10.1038/310074a0
• Nargeot, Joel and Nerbonne, Jeanne M., el al. (1983) Time Course of the Increase in the Myocardial Slow Inward Current after a Photochemically Generated Concentration Jump of Intracellular cAMP; Proceedings of the National Academy of Sciences of the United States of America; Vol. 80; No. 8; 2395-2399; PMCID PMC393827
• Nerbonne, Jeanne M. and Sheridan, Robert E., el al. (1983) cis-3,3'-Bis-[α-(trimethylammonium)methyl]azobenzene (cis-Bis-Q). Purification and properties at acetylcholine receptors of Electrophorus electroplaques; Molecular pharmacology; Vol. 23; No. 2; 344-349
• Braun, Sergei and Tolkovsky, Aviva M., el al. (1982) Activation and inhibition of adenylate cyclase by hormones; Biochemical Society Transactions; Vol. 10; No. 6; 496-498; 10.1042/bst0100496
• Sheridan, Robert E. and Lester, Henry A. (1982) Functional Stoichiometry at the Nicotinic Receptor. The Photon Cross Section for Phase 1 Corresponds to Two Bis-Q Molecules per Channel; Journal of General Physiology; Vol. 80; No. 4; 499-515; PMCID PMC2228709; 10.1085/jgp.80.4.499
• Lester, Henry A. and Nerbonne, Jeanne M. (1982) Physiological and Pharmacological Manipulations with Light Flashes; Annual Review of Biophysics and Bioengineering; Vol. 11; 151-175; 10.1146/annurev.bb.11.060182.001055
• Nargeot, Joel and Lester, Henry A., el al. (1982) A photoisomerizable muscarinic antagonist. Studies of binding and of conductance relaxations in frog heart; Journal of General Physiology; Vol. 79; No. 4; 657-678; PMCID PMC2215484; 10.1085/jgp.79.4.657
• Lester, Henry A. and Steer, Michael L., el al. (1982) ADP-Ribosylation of Membrane Proteins in Cholinergic Nerve Terminals; Journal of Neurochemistry; Vol. 38; No. 4; 1080-1086; 10.1111/j.1471-4159.1982.tb05351.x
• Lester, Henry A. and Steer, Michael L., el al. (1982) Prostaglandin-Stimulated GTP Hydrolysis Associated with Activation of Adenylate Cyclase in Human Platelet Membranes; Proceedings of the National Academy of Sciences of the United States of America; Vol. 79; No. 3; 719-723; PMCID PMC345823
• Steer, M. L. and Braun, S., el al. (1982) Activation of adenylate cyclase from purified platelet membranes by prostaglandin E1 and its inhibition by L-epinephrine: mechanistic effects; Journal of Cyclic Nucleotide Research; Vol. 8; No. 5; 309-322
• Lester, Henry A. (1981) A potpourri of plucked patches; Nature; Vol. 294; No. 5840; 398-399; 10.1038/294398a0
• Lester, Henry A. and Nass, Menasche M., el al. (1980) Electrophysiological Experiments With Photoisomerizable Cholinergic Compounds: Review and Progress Report; Annals of the New York Academy of Sciences; Vol. 346; 475-490; 10.1111/j.1749-6632.1980.tb22118.x
• Lester, Henry A. and Krouse, Mauri E., el al. (1980) A covalently bound photoisomerizable agonist. Comparison with reversibly bound agonists at electrophorus electroplaques; Journal of General Physiology; Vol. 75; No. 2; 207-232; PMCID PMC2215740; 10.1085/jgp.75.2.207
• Armstrong, David L. and Lester, Henry A. (1979) The kinetics of tubocurarine action and restricted diffusion within the synaptic cleft; Journal of Physiology; Vol. 294; No. 1; 365-386; PMCID PMC1280562; 10.1113/jphysiol.1979.sp012935
• Lester, Henry A. and Krouse, Mauri E., el al. (1979) Light-activated drug confirms a mechanism of ion channel blockade; Nature; Vol. 280; No. 5722; 509-510; 10.1038/280509a0
• Wathey, John C. and Nass, Menasche M., el al. (1979) Numerical reconstruction of the quantal event at nicotinic synapses; Biophysical Journal; Vol. 27; No. 1; 145-164; PMCID PMC1328553; 10.1016/s0006-3495(79)85208-x
• Koblin, Donald D. and Lester, Henry A. (1979) Voltage-dependent and voltage-independent blockade of acetylcholine receptors by local anesthetics in Electrophorus electroplaques; Molecular Pharmacology; Vol. 15; No. 3; 559-580
• Lester, Henry A. (1978) Analysis of sodium and potassium redistribution during sustained permeability increases at the innervated face of Electrophorus electroplaques; Journal of General Physiology; Vol. 72; No. 6; 857-862; PMCID PMC2228490; 10.1085/jgp.72.6.847
• Nass, Menasche M. and Lester, Henry A., el al. (1978) Response of acetylcholine receptors to photoisomerizations of bound agonist molecules; Biophysical Journal; Vol. 24; No. 1; 135-160; PMCID PMC1473870; 10.1016/s0006-3495(78)85352-1
• Lester, Henry A. and Koblin, Donald D., el al. (1978) Role of voltage-sensitive receptors in nicotinic transmission; Biophysical Journal; Vol. 21; No. 3; 181-194; PMCID PMC1473691; 10.1016/s0006-3495(78)85518-0
• Sheridan, Robert E. and Lester, Henry A. (1977) Rates and equilibria at the acetylcholine receptor of electrophorus electroplaques. A study of neurally evoked postsynaptic currents and of voltage-jump relaxations; Journal of General Physiology; Vol. 70; No. 2; 187-219; PMCID PMC2228462; 10.1085/jgp.70.2.187
• Lester, Henry A. and Chang, Hai Won (1977) Response of acetylcholine receptors to rapid photochemically produced increases in agonist concentration; Nature; Vol. 266; No. 5600; 373-374; 10.1038/266373a0
• Lester, Henry A. (1977) The response to acetylcholine; Scientific American; Vol. 236; No. 2; 106-118; 10.1038/scientificamerican0277-106
• Sheridan, Robert E. and Lester, Henry A. (1975) Relaxation measurements on the acetylcholine receptor; Proceedings of the National Academy of Sciences of the United States of America; Vol. 72; No. 9; 3496-3500; PMCID PMC433021; 10.1073/pnas.72.9.3496
• Lester, Henry A. and Changeux, Jean-Pierre, el al. (1975) Conductance increases produced by bath application of cholinergic agonists to Electrophorus electroplaques; Journal of General Physiology; Vol. 65; No. 6; 797-816; PMCID PMC2214893; 10.1085/jgp.65.6.797
• Lester, H. A. (1972) Vulnerability of desensitized or curare-treated acetylcholine receptors to irreversible blockade by cobra toxin; Molecular Pharmacology; Vol. 8; No. 6; 632-644
• Lester, H. A. (1972) Blockade of acetylcholine receptors by cobra toxin: electrophysiological studies; Molecular Pharmacology; Vol. 8; No. 6; 623-631
• Lester, Henry A. (1970) Postsynaptic Action of Cobra Toxin at the Myoneural Junction; Nature; Vol. 227; No. 5259; 727-728; 10.1038/227727a0
• Lester, Henry A. (1970) Transmitter Release by Presynaptic Impulses in the Squid Stellate Ganglion; Nature; Vol. 227; No. 5257; 493-496; 10.1038/227493a0