[ { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/yne46-qh583", "eprint_id": 87530, "eprint_status": "archive", "datestamp": "2023-08-22 02:59:17", "lastmod": "2023-10-18 21:14:46", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Smith-R-F", "name": { "family": "Smith", "given": "Randall F." } }, { "id": "Konopka-R-J", "name": { "family": "Konopka", "given": "Ronald J." } } ] }, "title": "Effects of dosage alterations at the per locus on the period of the circadian clock of Drosophila", "ispublished": "pub", "full_text_status": "public", "keywords": "Gene Product; Locomotor Activity; Circadian Rhythm; Product Activity; Mutant Allele", "note": "\u00a9 1982 Springer-Verlag. \n\nReceived: 01 December 1981.", "abstract": "The normal 24-h period of the circadian rhythms of locomotor activity and eclosion of Drosophila melanogaster is altered by changes in per gene dosage. Females with only one dose of per^+ or per^ s (the 19-h short-period mutant allele) or per^1 (the 29-h long-period mutant allele) have periods which are about 1\u20132 h longer than the corresponding females with 2 doses. Females with 3 doses of per^+ and males with 2 doses of per^+ or per ^s have periods which are 1/2 to 1 h shorter than the corresponding individuals without the extra dose. Males with three per^+ doses have periods which are about 1.5 h shorter than wild-type males; additional per^+ doses do not shorten period further. The observation that decreased per dosage lengthens period while increased dosage shortens period suggests that the long- and short-period mutations alter period by respectively decreasing and increasing per gene or gene product activity. The per^+ dosage results and the complementation behavior of per s indicate that the hypermorphic phenotype of per^ s results from increased activity of the per^ s gene product rather than an overproduction of per^+ product. This is the first report of such a mutant action in Drosophila.", "date": "1982-03", "date_type": "published", "publication": "Molecular Genetics and Genomics", "volume": "185", "number": "1", "publisher": "Springer", "pagerange": "30-36", "id_number": "CaltechAUTHORS:20180702-151816675", "issn": "1617-4615", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180702-151816675", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "doi": "10.1007/BF00333786", "resource_type": "article", "pub_year": "1982", "author_list": "Smith, Randall F. and Konopka, Ronald J." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/3c85z-hy342", "eprint_id": 87526, "eprint_status": "archive", "datestamp": "2023-08-22 02:48:22", "lastmod": "2023-10-18 21:14:34", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Smith-R-F", "name": { "family": "Smith", "given": "Randall F." } }, { "id": "Konopka-R-J", "name": { "family": "Konopka", "given": "Ronald J." } } ] }, "title": "Circadian clock phenotypes of chromosome aberrations with a breakpoint at the per locus", "ispublished": "pub", "full_text_status": "public", "keywords": "Circadian Rhythm; Mutant Allele; Genetic Control; Compelling Evidence; Circadian Clock", "note": "\u00a9 1981 Springer-Verlag. \n\nReceived: 06 June 1981.", "abstract": "The circadian rhythm phenotypes of eight chromosome aberrations with a breakpoint in the region of the per locus (3B1-2) were analyzed. Two duplications and five deficiencies with a 3B1-2 breakpoint produce either a wild-type or an arrhythmic clock phenotype while one translocation with a 3B1-2 breakpoint, T(1;4)JC43, produces locomotor-activity rhythms with either very-long period (31\u201339 h), rhythms that grade into arrhythmicity, or completely arrhythmic phenotypes. This is a unique phenotype that had not previously been observed for mutants at the per locus. An extensive complementation analysis of 3B1-2 chromosome aberrations and per mutant alleles provided no compelling evidence for genetic complexity at the per locus. This is in contrast to the report of Young and Judd (1978). Analysis of both the locomotor-activity and eclosion phenotypes of 3B1-2 chromosome aberrations did not uncover differences in the genetic control of these two rhythms. The clock phenotypes of 3B1-2 chromosome aberrations, the three per mutant alleles, and per+ duplications suggest that mutations at the per locus shorten, lengthen, or eliminate periodicity by respectively increasing, decreasing, or eliminating per activity.", "date": "1981-10", "date_type": "published", "publication": "Molecular and General Genetics", "volume": "183", "number": "2", "publisher": "Springer", "pagerange": "243-251", "id_number": "CaltechAUTHORS:20180702-140616003", "issn": "1617-4615", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180702-140616003", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "doi": "10.1007/BF00270625", "resource_type": "article", "pub_year": "1981", "author_list": "Smith, Randall F. and Konopka, Ronald J." }, { "id": "https://authors.library.caltech.eduhttps://authors.library.caltech.edu/records/p4v22-3nd61", "eprint_id": 7605, "eprint_status": "archive", "datestamp": "2023-08-22 00:08:27", "lastmod": "2023-10-16 20:59:53", "type": "article", "metadata_visibility": "show", "creators": { "items": [ { "id": "Konopka-R-J", "name": { "family": "Konopka", "given": "Ronald J." } }, { "id": "Benzer-S", "name": { "family": "Benzer", "given": "Seymour" } } ] }, "title": "Clock mutants of Drosophila melanogaster", "ispublished": "pub", "full_text_status": "public", "keywords": "eclosion; circadian; rhythms; X chromosome", "note": "\u00a9 1971 by the National Academy of Sciences. \n\nContributed by Seymour Benzer, July 2, 1971. \n\nThis work was supported by a grant from the National Science Foundation to S.B. and a National Science Foundation predoctoral fellowship to R.K. We thank Dr. Colin Pittendrigh for enlightening discussions and for the loan of several bang boxes, Dr. Yoshiki Hotta for design and construction of the activity detectors, and Barbara Stewart for help with the mapping experiments.\n\n
Published - KONpnas71.pdf
", "abstract": "Three mutants have been isolated in which the normal 24-hour rhythm is drastically changed. One mutant is arrhythmic; another has a period of 19 hr; a third has a period of 28 hr. Both the eclosion rhythm of a population and the locomotor activity of individual flies are affected. All these mutations appear to involve the same functional gene on the X chromosome.", "date": "1971-09", "date_type": "published", "publication": "Proceedings of the National Academy of Sciences of the United States of America", "volume": "68", "number": "9", "publisher": "National Academy of Sciences", "pagerange": "2112-2116", "id_number": "CaltechAUTHORS:KONpnas71", "issn": "0027-8424", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:KONpnas71", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NSF Graduate Research Fellowship" } ] }, "doi": "10.1073/pnas.68.9.2112", "pmcid": "PMC389363", "primary_object": { "basename": "KONpnas71.pdf", "url": "https://authors.library.caltech.edu/records/p4v22-3nd61/files/KONpnas71.pdf" }, "resource_type": "article", "pub_year": "1971", "author_list": "Konopka, Ronald J. and Benzer, Seymour" } ]