[
    {
        "id": "authors:fq5p7-dzr61",
        "collection": "authors",
        "collection_id": "fq5p7-dzr61",
        "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20121108-110709029",
        "type": "conference_item",
        "title": "Modelling Ca2+ -dependent proteins in the spine - challenges and solutions",
        "author": [
            {
                "family_name": "Stefan",
                "given_name": "Melanie I.",
                "clpid": "Stefan-M-I"
            },
            {
                "family_name": "Pepke",
                "given_name": "Shirley",
                "clpid": "Pepke-S"
            },
            {
                "family_name": "Mihalas",
                "given_name": "Stefan",
                "clpid": "Mihalas-S"
            },
            {
                "family_name": "Bartol",
                "given_name": "Thomas",
                "clpid": "Bartol-T"
            },
            {
                "family_name": "Sejnowski",
                "given_name": "Terrence J.",
                "orcid": "0000-0002-0622-7391",
                "clpid": "Sejnowski-T-J"
            },
            {
                "family_name": "Kennedy",
                "given_name": "Mary B.",
                "orcid": "0000-0003-1369-0525",
                "clpid": "Kennedy-M-B"
            }
        ],
        "abstract": "Background / Purpose:\n\nModelling post-synaptic proteins poses three technical problems: small absolute molecule numbers, large numbers of possible states, and the complex geometry of the spine, which is not a well-mixed compartment. Computational approaches are needed that solve all three of these problems.\n\nMain conclusion:\n\nStochastic simulation methods can be used for systems with small molecule numbers, agent-based methods to represent multi-state molecules, and spatial methods to simulate events in complex geometries. We used the agent-based spatial stochastic simulator MCell to model the Ca2+-dependent activation of calmodulin and Ca2+/calmodulin-dependent kinase II (CaMKII) in the spine.\n\nNext steps:\n\nNext steps will include the extension of our model to include more interaction partners, and to represent some of the regulation events in more detail.",
        "publisher": "Caltech Library",
        "publication_date": "2012-09"
    }
]