@article{https://resolver.caltech.edu/CaltechAUTHORS:20191022-104814157, title = "Sympathetic Effects of Internal Carotid Nerve Manipulation on Choroidal Vascularity and Related Measures", journal = "Investigative Ophthalmology and Visual Science", url = "https://resolver.caltech.edu/CaltechAUTHORS:20191022-104814157", id = "record", issn = "1552-5783", doi = "10.1167/iovs.18-25613", volume = "60" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20191031-140439364, title = "Toxicity of Transition Metal Complex-based Nanophotoswitches in Retina", journal = "Investigative Ophthalmology and Visual Science", url = "https://resolver.caltech.edu/CaltechAUTHORS:20191031-140439364", id = "record", issn = "0146-0404", volume = "60" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20191031-114840016, title = "Recovery of retinal oxygenation after MEMS implant activation", journal = "Investigative Ophthalmology and Visual Science", url = "https://resolver.caltech.edu/CaltechAUTHORS:20191031-114840016", id = "record", issn = "0146-0404", volume = "60" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20191025-124827181, title = "2019 IEEE 32nd International Conference on Micro Electro Mechanical Systems (MEMS)", chapter = "Wireless Implantable Intraocular Pressure Sensor with Parylene-Oil-Encapsulation and Forward-Angled RF Coil", url = "https://resolver.caltech.edu/CaltechAUTHORS:20191025-124827181", id = "record", isbn = "9781728116105", doi = "10.1109/memsys.2019.8870787" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20181010-142930931, title = "Activity of iridium pyridine-based nanophotoswitches in retina", journal = "Investigative Ophthalmology and Visual Science", url = "https://resolver.caltech.edu/CaltechAUTHORS:20181010-142930931", id = "record", issn = "0146-0404", volume = "59" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20180926-123802831, title = "Precision Wireless Implantable 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@article{https://resolver.caltech.edu/CaltechAUTHORS:20181010-144747080, title = "Effectiveness and Safety of a phototherapeutic contact lens for Diabetic Retinopathy", journal = "Investigative Ophthalmology and Visual Science", url = "https://resolver.caltech.edu/CaltechAUTHORS:20181010-144747080", id = "record", issn = "0146-0404", volume = "59" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20180518-135417850, title = "2018 IEEE Custom Integrated Circuits Conference (CICC)", chapter = "A wireless, low-drift, implantable intraocular pressure sensor with parylene-on-oil encapsulation", url = "https://resolver.caltech.edu/CaltechAUTHORS:20180518-135417850", id = "record", isbn = "978-1-5386-2483-8", doi = "10.1109/CICC.2018.8357049" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20180503-104340333, title = "2018 IEEE Micro Electro Mechanical Systems (MEMS)", chapter = "Phototherapeutic contact lens for diabetic retinopathy", url = "https://resolver.caltech.edu/CaltechAUTHORS:20180503-104340333", id = "record", isbn = "978-1-5386-4782-0", doi = "10.1109/MEMSYS.2018.8346482" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20171108-141114924, title = "Development of a new tissue injector for subretinal transplantation of human embryonic stem cell derived retinal pigmented epithelium", journal = "International Journal of Retina and Vitreous", url = "https://resolver.caltech.edu/CaltechAUTHORS:20171108-141114924", id = "record", issn = "2056-9920", doi = "10.1186/s40942-017-0095-6", volume = "3", pmcid = "PMC5662097" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20180322-102107647, title = "2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS)", chapter = "Implantable phototherapy device to treat diabetic retinopathy", url = "https://resolver.caltech.edu/CaltechAUTHORS:20180322-102107647", id = "record", isbn = "978-1-5386-2732-7", doi = "10.1109/TRANSDUCERS.2017.7994070" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20160624-130219973, title = "Biomimetic Accommodating Intraocular Lens Using a Valved Deformable Liquid Balloon", journal = "IEEE Transactions on Biomedical Engineering", url = "https://resolver.caltech.edu/CaltechAUTHORS:20160624-130219973", id = "record", issn = "0018-9294", doi = "10.1109/TBME.2015.2484379", volume = "63" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20160307-094844172, title = "Spatial Variations in Vitreous Oxygen Consumption", journal = "PLoS ONE", url = "https://resolver.caltech.edu/CaltechAUTHORS:20160307-094844172", id = "record", issn = "1932-6203", doi = "10.1371/journal.pone.0149961", volume = "11", pmcid = "PMC4773158" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20161013-103650860, title = "29th International Conference on Micro Electro Mechanical Systems (MEMS), 2016", chapter = "Oxygen generation by electrolysis to treat retinal ischemia", url = "https://resolver.caltech.edu/CaltechAUTHORS:20161013-103650860", id = "record", isbn = "978-1-5090-1973-1", doi = "10.1109/MEMSYS.2016.7421645" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20141111-093651164, title = "Ion Implants as Matrix-Appropriate Calibrators for Geochemical Ion Probe Analyses", journal = "Geostandards and Geoanalytical Research", url = "https://resolver.caltech.edu/CaltechAUTHORS:20141111-093651164", id = "record", issn = "1639-4488", doi = "10.1111/j.1751-908X.2014.00318.x", volume = "39" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20151119-105828360, title = "Spatial Variation in Vitreous Oxygen Consumption", journal = "Investigative Ophthalmology and Visual Science", url = "https://resolver.caltech.edu/CaltechAUTHORS:20151119-105828360", id = "record", issn = "0146-0404", volume = "56" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20151113-113545991, title = "Imaging Novel Ruthenium bipyridine-based Nanophotoswitches in Retina", journal = "Investigative ophthalmology \& visual science", url = "https://resolver.caltech.edu/CaltechAUTHORS:20151113-113545991", id = "record", issn = "0146-0404", volume = "56" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20151119-105156530, title = "Retinal Vascular Oxygen Saturation in Diabetic Rats: A Study using Hyperspectral Computed Tomographic Imaging Spectroscopy", journal = "Investigative Ophthalmology and Visual Science", url = "https://resolver.caltech.edu/CaltechAUTHORS:20151119-105156530", id = "record", issn = "0146-0404", volume = "56" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20150605-135556686, title = "Optical Interactions with Tissue and Cells XXVI", chapter = "Simulation and measurement of transcranial near infrared light penetration", url = "https://resolver.caltech.edu/CaltechAUTHORS:20150605-135556686", id = "record", isbn = "978-1-62841-411-0", doi = "10.1117/12.2077019" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20160317-142016193, title = "28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2015)", chapter = "MEMS oxygen transporter to treat retinal ischemia", url = "https://resolver.caltech.edu/CaltechAUTHORS:20160317-142016193", id = "record", isbn = "978-1-4799-7955-4", doi = "10.1109/MEMSYS.2015.7050909" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20140225-114331568, title = "A Fully Intraocular High-Density Self-Calibrating Epiretinal Prosthesis", journal = "IEEE Transactions on Biomedical Circuits and Systems", url = "https://resolver.caltech.edu/CaltechAUTHORS:20140225-114331568", id = "record", issn = "1932-4545", doi = "10.1109/TBCAS.2014.2298334", volume = "7" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20140520-140334969, title = "2013 Transducers \& Eurosensors XXVII", chapter = "Parylene origami structure for intraocular implantation", url = "https://resolver.caltech.edu/CaltechAUTHORS:20140520-140334969", id = "record", isbn = "9781467359818", doi = "10.1109/Transducers.2013.6627077" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20170125-164509091, title = "2013 IEEE International Solid-State Circuits Conference Digest of Technical Papers", chapter = "A fully intraocular 0.0169 mm^2/pixel 512-channel self-calibrating epiretinal prosthesis in 65nm CMOS", url = "https://resolver.caltech.edu/CaltechAUTHORS:20170125-164509091", id = "record", isbn = "978-1-4673-4516-3", doi = "10.1109/ISSCC.2013.6487742" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20130729-090047591, title = "IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS)", chapter = "Packaging study for a 512-channel intraocular epiretinal implant", url = "https://resolver.caltech.edu/CaltechAUTHORS:20130729-090047591", id = "record", isbn = "978-1-4673-5654-1", doi = "10.1109/MEMSYS.2013.6474428" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20120828-133907808, title = "Feeling the Pressure: A Parylene-Based Intraocular Pressure Sensor", journal = "IEEE Nanotechnology Magazine", url = "https://resolver.caltech.edu/CaltechAUTHORS:20120828-133907808", id = "record", issn = "1932-4510", doi = "10.1109/MNANO.2012.2203876", volume = "6" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20120730-114002078, title = "Mesh-supported submicron parylene-C membranes for culturing retinal pigment epithelial cells", journal = "Biomedical Microdevices", url = "https://resolver.caltech.edu/CaltechAUTHORS:20120730-114002078", id = "record", issn = "1387-2176", doi = "10.1007/s10544-012-9645-8", volume = "14" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20121002-155323510, title = "Evidence for Unfractionated Magnesium Isotopes in Genesis SOS Wafers", journal = "Meteoritics and Planetary Science", url = "https://resolver.caltech.edu/CaltechAUTHORS:20121002-155323510", id = "record", issn = "1086-9379", doi = "10.1111/j.1945-5100.2012.01401\_2.x", volume = "47" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20130201-100453140, title = "2012 IEEE 25th International Conference on Micro Electro Mechanical Systems", chapter = "A 3D parylene scaffold cage for culturing retinal pigment epithelial cells", url = "https://resolver.caltech.edu/CaltechAUTHORS:20130201-100453140", id = "record", isbn = "978-1-4673-0325-5", doi = "10.1109/MEMSYS.2012.6170292" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20170213-164318264, title = "16th International Solid-State Sensors, Actuators and Microsystems Conference", chapter = "Semipermeable parylene membrane as an artificial Bruch's membrane", url = "https://resolver.caltech.edu/CaltechAUTHORS:20170213-164318264", id = "record", isbn = "978-1-4577-0156-6", doi = "10.1109/TRANSDUCERS.2011.5969376" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20110506-112304271, title = "Parylene-based integrated wireless single-channel neurostimulator", journal = "Sensors and Actuators A", url = "https://resolver.caltech.edu/CaltechAUTHORS:20110506-112304271", id = "record", issn = "0924-4247", doi = "10.1016/j.sna.2010.03.003", volume = "166" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20101117-094431583, title = "Wireless Intraocular Pressure Sensing Using Microfabricated Minimally Invasive Flexible-Coiled LC Sensor Implant", journal = "Journal of Microelectromechanical Systems", url = "https://resolver.caltech.edu/CaltechAUTHORS:20101117-094431583", id = "record", issn = "1057-7157", doi = "10.1109/JMEMS.2010.2049825", volume = "19" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20101118-134541510, title = "Wafer-Level Parylene Packaging With Integrated RF Electronics for Wireless Retinal Prostheses", journal = "Journal of Microelectromechanical Systems", url = "https://resolver.caltech.edu/CaltechAUTHORS:20101118-134541510", id = "record", issn = "1057-7157", doi = "10.1109/JMEMS.2010.2049985", volume = "19" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20170314-161916848, title = "IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems", chapter = "Ex Vivo implantation study of minimally invasive glaucoma drainage device", url = "https://resolver.caltech.edu/CaltechAUTHORS:20170314-161916848", id = "record", isbn = "978-1-4244-6545-3", doi = "10.1109/NEMS.2010.5592223" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20170323-135102342, title = "IEEE 22nd International Conference on Micro Electro Mechanical Systems", chapter = "Minimally Invasive Parylene Dual-Valved Flow Drainage Shunt for Glaucoma Implant", url = "https://resolver.caltech.edu/CaltechAUTHORS:20170323-135102342", id = "record", isbn = "978-1-4244-2977-6", doi = "10.1109/MEMSYS.2009.4805352" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20170327-174424552, title = "IEEE 22nd International Conference on Micro Electro Mechanical Systems", chapter = "Implantable Flexible-Coiled Wireless Intraocular Pressure Sensor", url = "https://resolver.caltech.edu/CaltechAUTHORS:20170327-174424552", id = "record", isbn = "978-1-4244-2977-6", doi = "10.1109/MEMSYS.2009.4805364" } @article{https://resolver.caltech.edu/CaltechAUTHORS:CHEjmems08b, title = "Floating-Disk Parylene Microvalves for Self-Pressure-Regulating Flow Controls", journal = "Journal of Microelectromechanical Systems", url = "https://resolver.caltech.edu/CaltechAUTHORS:CHEjmems08b", id = "record", issn = "1057-7157", doi = "10.1109/JMEMS.2008.2004947", volume = "17" } @article{https://resolver.caltech.edu/CaltechAUTHORS:CHEjmems08a, title = "Microfabricated Implantable Parylene-Based Wireless Passive Intraocular Pressure Sensors", journal = "Journal of Microelectromechanical Systems", url = "https://resolver.caltech.edu/CaltechAUTHORS:CHEjmems08a", id = "record", issn = "1057-7157", doi = "10.1109/JMEMS.2008.2004945", volume = "17" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20190322-120334812, title = "2008 IEEE International Electron Devices Meeting", chapter = "Systems design of a high resolution retinal prosthesis", url = "https://resolver.caltech.edu/CaltechAUTHORS:20190322-120334812", id = "record", isbn = "9781424423774", doi = "10.1109/iedm.2008.4796682" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20100726-104029245, title = "Flexible parylene-based multielectrode array technology for high-density neural stimulation and recording", journal = "Sensors and Actuators B: Chemical", url = "https://resolver.caltech.edu/CaltechAUTHORS:20100726-104029245", id = "record", issn = "0925-4005", doi = "10.1016/j.snb.2007.10.069", volume = "132" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20100708-110900771, title = "An electrochemical intraocular drug delivery device", journal = "Sensors and Actuators A", url = "https://resolver.caltech.edu/CaltechAUTHORS:20100708-110900771", id = "record", issn = "0924-4247", doi = "10.1016/j.sna.2007.06.034", volume = "143" } @article{https://resolver.caltech.edu/CaltechAUTHORS:HANjbo08, title = "Handheld forward-imaging needle endoscope for ophthalmic optical coherence tomography inspection", journal = "Journal of Biomedical Optics", url = "https://resolver.caltech.edu/CaltechAUTHORS:HANjbo08", id = "record", issn = "1083-3668", doi = "10.1117/1.2904664", volume = "13" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20100722-110448277, title = "MEMS 2008 Tucson : 21st IEEE International Conference on Micro Electro Mechanical Systems", chapter = "Implantable parylene-based wireless intraocular pressure sensor", url = "https://resolver.caltech.edu/CaltechAUTHORS:20100722-110448277", id = "record", isbn = "978-1-4244-1792-6", doi = "10.1109/MEMSYS.2008.4443592" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20100813-083041941, title = "MEMS 2008 Tucson : 21st IEEE International Conference on Micro Electro Mechanical 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} @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20180716-112901034, title = "Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI", chapter = "Endoscopic optical coherence tomography of the retina at 1310 nm using paired-angle rotating scanning", url = "https://resolver.caltech.edu/CaltechAUTHORS:20180716-112901034", id = "record", isbn = "9780819465429", doi = "10.1117/12.701226" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20110721-094836263, title = "Microtechnologies in Medicine and Biology", chapter = "Flexible Parylene Packaged Intraocular Coil for Retinal Prostheses", url = "https://resolver.caltech.edu/CaltechAUTHORS:20110721-094836263", id = "record", isbn = "978-1-4244-0337-0", doi = "10.1109/MMB.2006.251502" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20101112-151218275, title = "2006 International Conference on Microtechnologies in Medicine and Biology", chapter = "Implantable Unpowered Parylene MEMS Intraocular Pressure Sensor", url = "https://resolver.caltech.edu/CaltechAUTHORS:20101112-151218275", id = "record", isbn = "978-1-4244-0337-0", doi = "10.1109/MMB.2006.251543" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20110720-113158743, title = "2006 International Conference on Microtechnologies in Medicine and Biology", chapter = "Flexible Microfabricated Parylene Multielectrode Arrays for Retinal Stimulation and Spinal Cord Field Modulation", url = "https://resolver.caltech.edu/CaltechAUTHORS:20110720-113158743", id = "record", isbn = "978-1-4244-0337-0", doi = "10.1109/MMB.2006.251482" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20110120-133620929, title = "Unpowered spiral-tube parylene pressure sensor for intraocular pressure sensing", journal = "Sensors and Actuators A", url = "https://resolver.caltech.edu/CaltechAUTHORS:20110120-133620929", id = "record", issn = "0924-4247", doi = "10.1016/j.sna.2005.08.027", volume = "127" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20110218-111423210, title = "2006 1st IEEE International Conference on Nano/Micro Engineered and Molecular Systems", chapter = "Flexible Parylene-based Microelectrode Technology for Intraocular Retinal Prostheses", url = "https://resolver.caltech.edu/CaltechAUTHORS:20110218-111423210", id = "record", isbn = "1-4244-0139-9", doi = "10.1109/NEMS.2006.334886" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20190322-154442882, title = "2005 IEEE Engineering in Medicine and Biology 27th Annual Conference", chapter = "Progress Towards A High-Resolution Retinal Prosthesis", url = "https://resolver.caltech.edu/CaltechAUTHORS:20190322-154442882", id = "record", isbn = "0-7803-8741-4", doi = "10.1109/IEMBS.2005.1616215" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20110825-150721909, title = "Transducers '05 : 13th International Conference on Solid-State Sensors, Actuators, and Microsystems", chapter = "Scalable flexible chip-level parylene package for high lead count retinal prostheses", url = "https://resolver.caltech.edu/CaltechAUTHORS:20110825-150721909", id = "record", isbn = "0-7803-8994-8", doi = "10.1109/SENSOR.2005.1497487" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20110818-114326452, title = "Proceedings of the 3rd Annual International IEEE EMBS Special Topic Conference on Microtechnologies in Medicine and Biology", chapter = "Implantable parylene MEMS for glaucoma therapy", url = "https://resolver.caltech.edu/CaltechAUTHORS:20110818-114326452", id = "record", isbn = "0-7803-8711-2", doi = "10.1109/MMB.2005.1548399" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:20110609-114150828, title = "MEMS 2005 Miami : 18th IEEE International Conference on Micro Electro Mechanical Systems", chapter = "Spiral-Tube Parylene Intraocular Pressure Sensor", url = "https://resolver.caltech.edu/CaltechAUTHORS:20110609-114150828", id = "record", isbn = "0-7803-8732-5", doi = "10.1109/MEMSYS.2005.1453929" } @inbook{https://resolver.caltech.edu/CaltechAUTHORS:KAZembc04, title = "International Conference of the IEEE Engineering in Medicine and Biology Society, 26th (IEMBS '04), San Francisco, CA, 1-5 September 2004", chapter = "A test microchip for evaluation of hermetic packaging technology for biomedical prosthetic implants", url = "https://resolver.caltech.edu/CaltechAUTHORS:KAZembc04", id = "record", isbn = "0-7803-8439-3", doi = "10.1109/IEMBS.2004.1404142" } @article{https://resolver.caltech.edu/CaltechAUTHORS:20200309-161405106, title = "Passage of Heme-Iron Across the Envelope of Staphylococcus aureus", journal = "Science", url = "https://resolver.caltech.edu/CaltechAUTHORS:20200309-161405106", id = "record", issn = "0036-8075", doi = "10.1126/science.1081147", volume = "299" }