[ { "id": "authors:51ha7-d4e66", "collection": "authors", "collection_id": "51ha7-d4e66", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20111223-103012103", "type": "article", "title": "Passions", "author": [ { "family_name": "Huang", "given_name": "Alice S.", "clpid": "Huang-Alice-S" } ], "abstract": "What is the secret to success in science or anything else? Hard work alone is not enough. It is being passionate about\nsomething, enough to make a whole-hearted commitment of creativity, rigor, and determination. Let me share my lifelong passions. Foremost, I am passionate about investigating viruses and finding ways to control their\ngrowth. Along the way, I have also developed\nother passions: using science to build international\nbridges, improving science education, and maximizing access to science for diverse populations, especially women and minorities. I have sometimes wondered why these three issues have attracted me. Perhaps it is because social justice, fairness, and access to opportunities were the ideals that caused my family to make the United States our home. I have embraced my passions, and they have\nrichly rewarded me.", "doi": "10.1126/science.1213199", "issn": "0036-8075", "publisher": "American Association for the Advancement of Science", "publication": "Science", "publication_date": "2011-12-09", "series_number": "6061", "volume": "334", "issue": "6061", "pages": "1362-1366" }, { "id": "authors:bzjtp-yq852", "collection": "authors", "collection_id": "bzjtp-yq852", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20110314-102849321", "type": "article", "title": "Why Bother?", "author": [ { "family_name": "Huang", "given_name": "Alice S.", "clpid": "Huang-Alice-S" } ], "abstract": "When we mention women in Science and Engineering, it is often about the diminishing numbers, the lower pay, the many difficulties for women, and the personal sacrifices that women necessarily make. Perhaps, by focusing on the negatives, we are unwittingly persuading young women that science and engineering may not be the right careers for them. Why bother to join this profession?", "doi": "10.1126/science.1203124", "issn": "0036-8075", "publisher": "American Association for the Advancement of Science", "publication": "Science", "publication_date": "2011-02-18", "series_number": "6019", "volume": "331", "issue": "6019", "pages": "821-821" }, { "id": "authors:z4z48-ftv47", "collection": "authors", "collection_id": "z4z48-ftv47", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20100928-100302809", "type": "article", "title": "Achieving Scientific Eminence Within Asia", "author": [ { "family_name": "Huang", "given_name": "Alice S.", "clpid": "Huang-Alice-S" }, { "family_name": "Tan", "given_name": "Chris Y. H.", "clpid": "Tan-Chris-Y-H" } ], "abstract": "Asian countries are poised to help solve modern biological problems, but some policies and practices need reform.", "doi": "10.1126/science.1190145", "issn": "0036-8075", "publisher": "American Association for the Advancement of Science", "publication": "Science", "publication_date": "2010-09-17", "series_number": "5998", "volume": "329", "issue": "5998", "pages": "1471-1472" }, { "id": "authors:m6kn0-7s925", "collection": "authors", "collection_id": "m6kn0-7s925", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20150327-082158447", "type": "article", "title": "Follow your nose", "author": [ { "family_name": "Huang", "given_name": "Alice Shih-hou", "clpid": "Huang-Alice-S" } ], "abstract": "Alice Shih-hou Huang draws on her own experience to highlight the many careers and opportunities open to scientists in the West and in China.", "doi": "10.1038/428221a", "issn": "0028-0836", "publisher": "Nature Publishing Group", "publication": "Nature", "publication_date": "2004-03-11", "series_number": "6979", "volume": "428", "issue": "6979", "pages": "221-222" }, { "id": "authors:abazd-fha10", "collection": "authors", "collection_id": "abazd-fha10", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:HUAjvir73", "type": "article", "title": "Growth of Pseudotypes of Vesicular Stomatitis Virus with N-Tropic Murine Leukemia Virus Coats in Cells Resistant to N-Tropic Viruses", "author": [ { "family_name": "Huang", "given_name": "Alice S.", "clpid": "Huang-Alice-S" }, { "family_name": "Besmer", "given_name": "Peter", "clpid": "Besmer-Peter" }, { "family_name": "Chu", "given_name": "Louise", "clpid": "Chu-Louise" }, { "family_name": "Baltimore", "given_name": "David", "orcid": "0000-0001-8723-8190", "clpid": "Baltimore-D" } ], "abstract": "Formation of pseudotypes between murine RNA tumor viruses and vesicular stomatitis virus (VSV) has been confirmed. Pseudotypes of VSV genomes coated by the surface envelope from an N-tropic tumor virus grew equally well in cells homozygous for either the Fv-1n or Fv-1b alleles. Therefore, the product of the Fv-1 locus, which restricts growth of murine RNA tumor viruses, must act on an intracellular aspect of tumor virus replication, a step after attachment and penetration.", "doi": "10.1128/jvi.12.3.659-662.1973", "pmcid": "PMC356675", "issn": "0022-538X", "publisher": "American Society for Microbiology", "publication": "Journal of Virology", "publication_date": "1973-09", "series_number": "3", "volume": "12", "issue": "3", "pages": "659-662" }, { "id": "authors:ht6a9-twn97", "collection": "authors", "collection_id": "ht6a9-twn97", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20120801-153855963", "type": "article", "title": "Absence of Interference During High-Multiplicity Infection by Clonally Purified Vesicular Stomatitis Virus", "author": [ { "family_name": "Stampfer", "given_name": "Martha", "clpid": "Stampfer-Martha" }, { "family_name": "Baltimore", "given_name": "David", "orcid": "0000-0001-8723-8190", "clpid": "Baltimore-D" }, { "family_name": "Huang", "given_name": "Alice S.", "clpid": "Huang-Alice-S" } ], "abstract": "Stocks of vesicular stomatitis virus free of defective interfering particles were produced by serial clonal isolation. High-multiplicity infections with these stocks led to no interference or formation of defective interfering particles. Defective interfering particles were generated by three successive passages at high multiplicity.", "pmcid": "PMC356132", "issn": "0022-538X", "publisher": "American Society for Microbiology", "publication": "Journal of Virology", "publication_date": "1971-03", "series_number": "3", "volume": "7", "issue": "3", "pages": "409-411" }, { "id": "authors:x61cq-kha51", "collection": "authors", "collection_id": "x61cq-kha51", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:HUAjvir71", "type": "article", "title": "Ribonucleic Acud Polymerase in Virions of Newcastle Disease Virus: Comparison with the Vesicular Stomatitis Virus Polymerase", "author": [ { "family_name": "Huang", "given_name": "Alice S.", "clpid": "Huang-Alice-S" }, { "family_name": "Baltimore", "given_name": "David", "orcid": "0000-0001-8723-8190", "clpid": "Baltimore-D" }, { "family_name": "Bratt", "given_name": "Michael A.", "clpid": "Bratt-Michael-A" } ], "abstract": "The virions of Newcastle disease virus (NDV) contained an enzyme that catalyzed the incorporation of ribonucleotides into ribonucleic acid (RNA). Optimal conditions for this polymerase activity were identical to the conditions for the vesicular stomatitis virus (VSV) polymerase, and both enzymes were active for longer times at 32 C than at 37 C. However, the specific activity of the NDV polymerase was less than 3% that of the VSV polymerase. Product RNA species from the NDV and VSV polymerase reactions annealed specifically to the homologous virion RNA species. Transcriptive intermediates containing product RNA attached to the respective virion RNA could be identified in both systems.", "issn": "0022-538X", "publisher": "Journal of Virology", "publication": "Journal of Virology", "publication_date": "1971-03", "series_number": "3", "volume": "7", "issue": "3", "pages": "389-394" }, { "id": "authors:2401n-26v97", "collection": "authors", "collection_id": "2401n-26v97", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20120725-095630032", "type": "article", "title": "Ribonucleic Acid Synthesis of Vesicular Stomatitis Virus,\n II. An RNA Polymerase in the Virion", "author": [ { "family_name": "Baltimore", "given_name": "David", "orcid": "0000-0001-8723-8190", "clpid": "Baltimore-D" }, { "family_name": "Huang", "given_name": "Alice S.", "clpid": "Huang-Alice-S" }, { "family_name": "Stampfer", "given_name": "Martha", "clpid": "Stampfer-Martha" } ], "abstract": "The virions of vesicular stomatitis virus contain an enzyme that catalyzes the incorporation of ribonucleotides into RNA. The product of the reaction is mainly RNA complementary in base sequence to that of vesicular stomatitis virus RNA.", "issn": "0027-8424", "publisher": "National Academy of Sciences", "publication": "Proceedings of the National Academy of Sciences of the United States of America", "publication_date": "1970-06", "series_number": "2", "volume": "66", "issue": "2", "pages": "572-576" }, { "id": "authors:1tmvj-szq89", "collection": "authors", "collection_id": "1tmvj-szq89", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:STAjvir69", "type": "article", "title": "Ribonucleic acid synthesis of vesicular stomatitis virus. I. Species of Ribonucleic Acid Found in Chinese Hamster Ovary Cells Infected with Plaque-forming and Defective Particles", "author": [ { "family_name": "Stampfer", "given_name": "Martha", "clpid": "Stampfer-Martha" }, { "family_name": "Baltimore", "given_name": "David", "orcid": "0000-0001-8723-8190", "clpid": "Baltimore-D" }, { "family_name": "Huang", "given_name": "Alice S.", "clpid": "Huang-Alice-S" } ], "abstract": "Plaque-forming B particles of vesicular stomatitis virus (VSV) induce the synthesis of virus-specific ribonucleic acid (RNA) in Chinese hamster ovary cells, whereas defective T particles do not. Infection with low input multiplicities of B results in the formation of four species of RNA. During infection with high multiplicities, RNA synthesis begins with mainly these four species of RNA but gradually shifts to a new pattern of RNA synthesis involving five other species of RNA. The change can also be induced by superinfection with T at 2.5 hr after infection with a low multiplicity of B. T added at the same time as B prevents virtually all RNA synthesis. Synthesis of the first group of RNA species correlates with the formation of B particles, whereas synthesis of the second group correlates with the formation of T particles. The various species of RNA formed after infection with VSV particles include single-stranded RNA, a completely double-stranded RNA, and RNA with partially double-stranded regions. These observations begin to establish a molecular basis for understanding the ability of T particles to interfere with the growth of B particles.", "issn": "0022-538X", "publisher": "Journal of Virology", "publication": "Journal of Virology", "publication_date": "1969-08", "series_number": "2", "volume": "4", "issue": "2", "pages": "154-161" }, { "id": "authors:vc1sy-8ke46", "collection": "authors", "collection_id": "vc1sy-8ke46", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20151203-135350370", "type": "article", "title": "Reversible inhibition of interferon synthesis by puromycin: evidence for an interferon-specific messenger RNA", "author": [ { "family_name": "Wagner", "given_name": "Robert R.", "clpid": "Wagner-R-R" }, { "family_name": "Huang", "given_name": "Alice S.", "clpid": "Huang-Alice-S" } ], "abstract": "The capacity to synthesize interferon appears to be a latent cellular function which is induced by viral infection or other stimuli. The sequence of events can be conveniently studied in suspended cultures of Krebs-2 mouse ascites cells infected with Newcastle disease virus (NDV). Interferon synthesis in this model system begins 3-4 hr after infection and reaches maximal levels within 20 hr after viral infection. Previous studies have shown that interferon formation requires unimpaired cellular RNA synthesis during the first 4 hr after viral induction. Following this time, interferon continues to be formed even if RNA synthesis is inhibited by actinomycin. The present experiments provide further support for the hypothesis that a virus can switch on the cellular interferon gene by inducing the transcription of a messenger RNA that specifies the synthesis of the interferon protein. These two events in the cycle of interferon production can be dissected by suppression of protein synthesis with puromycin and of RNA synthesis with actinomycin.", "pmcid": "PMC219807", "issn": "0027-8424", "publisher": "National Academy of Sciences", "publication": "Proceedings of the National Academy of Sciences of the United States of America", "publication_date": "1965-10-01", "series_number": "4", "volume": "54", "issue": "4", "pages": "1112-1118" }, { "id": "authors:6hhpa-z5244", "collection": "authors", "collection_id": "6hhpa-z5244", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20151203-132315755", "type": "article", "title": "Penetration of Herpes Simplex Virus into Human Epidermoid Cells", "author": [ { "family_name": "Huang", "given_name": "Alice S.", "clpid": "Huang-Alice-S" }, { "family_name": "Wagner", "given_name": "Robert R.", "clpid": "Wagner-R-R" } ], "abstract": "The kinetics of infective center formation was studied as a parameter of herpes simplex virus penetration into suspended HEp-2 cells. Similar rates of penetration were obtained when antibody or acid was used to inactivate virus attached to the cell surface, although the acid method was far more efficient and reliable. The data indicate that virus penetration is strictly temperature dependent and is virtually complete by 7 minutes at 37\u00b0, but the reaction does not conform to simple first order kinetics.", "doi": "10.3181/00379727-116-29392", "issn": "0037-9727", "publisher": "Society for Experimental Biology and Medicine", "publication": "Proceedings of the Society for Experimental Biology and Medicine", "publication_date": "1964-08", "series_number": "4", "volume": "116", "issue": "4", "pages": "863-869" } ]