[
    {
        "id": "authors:85pr2-h9v50",
        "collection": "authors",
        "collection_id": "85pr2-h9v50",
        "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20200928-103350812",
        "type": "monograph",
        "title": "Three-Dimensional Impedance Tomographic Mapping of Metabolically Active Endolumen",
        "author": [
            {
                "family_name": "Abiri",
                "given_name": "Parinaz",
                "orcid": "0000-0002-0520-6863",
                "clpid": "Abiri-P"
            },
            {
                "family_name": "Luo",
                "given_name": "Yuan",
                "clpid": "Luo-Yuan"
            },
            {
                "family_name": "Huang",
                "given_name": "Zi-Yu",
                "clpid": "Huang-Zi-Yu"
            },
            {
                "family_name": "Roustaei",
                "given_name": "Mehrdad",
                "clpid": "Roustaei-M"
            },
            {
                "family_name": "Duarte-Vogel",
                "given_name": "Sandra",
                "clpid": "Duarte-Vogel-S"
            },
            {
                "family_name": "Cui",
                "given_name": "Quinyu",
                "clpid": "Cui-Quinyu"
            },
            {
                "family_name": "Packard",
                "given_name": "Ren\u00e9 R. Sevag",
                "orcid": "0000-0002-8520-5843",
                "clpid": "Packard-R-R-S"
            },
            {
                "family_name": "Ebrahimi",
                "given_name": "Ramin",
                "clpid": "Ebrahimi-R"
            },
            {
                "family_name": "Benharash",
                "given_name": "Peyman",
                "clpid": "Benharash-P"
            },
            {
                "family_name": "Tai",
                "given_name": "Yu-Chong",
                "orcid": "0000-0001-8529-106X",
                "clpid": "Tai-Yu-Chong"
            },
            {
                "family_name": "Hsiai",
                "given_name": "Tzung K.",
                "orcid": "0000-0003-1734-0792",
                "clpid": "Hsiai-Tzung-K"
            }
        ],
        "abstract": "Real-time detection of vulnerable atherosclerotic lesions, characterized by a high content of oxidized low-density lipoprotein (oxLDL)-laden macrophages or foam cells, remains an unmet clinical need. While fractional flow reserve (FFR)-guided revascularization in angiographically intermediate stenoses is utilized to assess hemodynamic significance, in vivo detection of oxLDL-rich plaques may provide a new paradigm for treating metabolically unstable lesions. Herein, we have demonstrated endoluminal mapping of lipid-laden lesions using 3-D electrical impedance spectroscopy-derived impedance tomography (EIT) in a pre-clinical swine model. We performed surgical banding of the right carotid arteries of Yucatan mini-pigs, followed by 16 weeks of high-fat diet, to promote the development of lipid-rich lesions. We implemented an intravascular sensor combining an FFR pressure transducer with a 6-point micro-electrode array for electrical impedance spectroscopy (EIS) measurements. 3-D EIT mapping was achieved using an EIS-based reconstruction algorithm. We demonstrated that EIT mapping corresponds to endoluminal histology for oxLDL-laden lesions. We further used computational models to theoretically predict and validate EIS measurements. Thus, our 3-D EIS-derived EIT provides in vivo detection of metabolically active plaques with the goal of guiding optimal intravascular intervention.",
        "doi": "10.1101/2020.09.24.312025",
        "publication_date": "2020-09-25"
    }
]