[ { "id": "authors:t2s1d-tmj62", "collection": "authors", "collection_id": "t2s1d-tmj62", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20230605-334742000.5", "type": "book_section", "title": "Micron-Sized Parylene-In-Oil Water Protection Layer", "book_title": "2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS)", "author": [ { "family_name": "Shang", "given_name": "Kuang-Ming", "orcid": "0000-0001-5065-7607", "clpid": "Shang-Kuang-Ming" }, { "family_name": "Shen", "given_name": "Haixu", "clpid": "Shen-Haixu" }, { "family_name": "Dai", "given_name": "Ningxuan", "clpid": "Dai-Ningxuan" }, { "family_name": "Kong", "given_name": "David", "clpid": "Kong-David" }, { "family_name": "Hsiai", "given_name": "Tzung K.", "orcid": "0000-0003-1734-0792", "clpid": "Hsiai-Tzung-K" }, { "family_name": "Tai", "given_name": "Yu-Chong", "orcid": "0000-0001-8529-106X", "clpid": "Tai-Yu-Chong" } ], "abstract": "This work studies the parylene-in-oil composite layer as a water protection layer for biomedical applications where adhesion is critical. Compared to solid parylene, the parylene-in-oil film is thermodynamically favorable for preventing water condensation at the interface, subsequent parylene delamination, and underneath material corrosion. To study the effects of silicone oil thicknesses on the composite film, we fabricate test structures and measure both the dry and wet adhesion using a 180\u00b0 peeling test and an accelerated soak-to-delamination test in saline at 67\u00b0C, respectively. Results show that when the oil thickness of the film is between 1-2 \u00b5m, the wet adhesion increases a few folds while the dry adhesion remains adequate for implantable medical device applications.", "doi": "10.1109/mems49605.2023.10052444", "isbn": "978-1-6654-9308-6", "publisher": "IEEE", "place_of_publication": "Piscataway, NJ", "publication_date": "2023-01", "pages": "22774721" }, { "id": "authors:y6sdt-56n74", "collection": "authors", "collection_id": "y6sdt-56n74", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20190829-100211144", "type": "book_section", "title": "Double-Ballooned Local Drug Delivery Catheter with Blood Bypassing Function", "book_title": "2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)", "author": [ { "family_name": "Huang", "given_name": "Zi-Yu", "clpid": "Huang-Zi-Yu" }, { "family_name": "Luo", "given_name": "Yuan", "clpid": "Luo-Yuan" }, { "family_name": "Abiri", "given_name": "Parinaz", "clpid": "Abiri-P" }, { "family_name": "Packard", "given_name": "Rene R. S.", "orcid": "0000-0002-8520-5843", "clpid": "Packard-R-R-S" }, { "family_name": "Hsiai", "given_name": "Tzung K.", "orcid": "0000-0003-1734-0792", "clpid": "Hsiai-Tzung-K" }, { "family_name": "Tai", "given_name": "Yu-Chong", "orcid": "0000-0001-8529-106X", "clpid": "Tai-Yu-Chong" } ], "abstract": "We present a double-ballooned catheter that enables both local drug delivery and blood bypassing at the same time. Such catheters are targeted for high-dose local drug treatment of cardiovascular diseases, such as atherosclerosis and restenosis, allowing for extended use without causing downstream ischemia. The device is composed of two flexible balloons that can isolate the lesion under inflation. Local drug delivery can be achieved using the inner catheters while a blood bypassing catheter allows for continuous blood flow. The functionalities of the catheter are validated in both benchtop and live pig experiments.", "doi": "10.1109/transducers.2019.8808417", "isbn": "9781538681046", "publisher": "IEEE", "place_of_publication": "Piscataway, NJ", "publication_date": "2019-06", "pages": "2213-2216" }, { "id": "authors:0j5re-r2895", "collection": "authors", "collection_id": "0j5re-r2895", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20190829-100211037", "type": "book_section", "title": "Dual-Function Intravascular Catheter for Atherosclerosis Diagnostics", "book_title": "2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)", "author": [ { "family_name": "Luo", "given_name": "Yuan", "clpid": "Luo-Yuan" }, { "family_name": "Abiri", "given_name": "Parinaz", "clpid": "Abiri-P" }, { "family_name": "Packard", "given_name": "Rene R. S.", "orcid": "0000-0002-8520-5843", "clpid": "Packard-R-R-S" }, { "family_name": "Hsiai", "given_name": "Tzung K.", "orcid": "0000-0003-1734-0792", "clpid": "Hsiai-Tzung-K" }, { "family_name": "Tai", "given_name": "Yu-Chong", "orcid": "0000-0001-8529-106X", "clpid": "Tai-Yu-Chong" } ], "abstract": "We herein present a novel intravascular catheter, with dual-functions of electrical impedance spectroscopy (EIS) and flow fraction reserve (FFR), validated in live pig animal for atherosclerosis/plaques diagnostics. FFR has been the standard tool in determining plaque vulnerability yet could produce false negative results when stenosis is relatively small. Meanwhile, EIS has been demonstrated to specifically distinguish the lipid-rich pool, the signifying feature of rupture-prone plaques. The synergetic performance of these two functionalities can significantly enhance state-of-art diagnostics accuracy for atherosclerosis.", "doi": "10.1109/transducers.2019.8808540", "isbn": "9781538681046", "publisher": "IEEE", "place_of_publication": "Piscataway, NJ", "publication_date": "2019-06", "pages": "625-628" }, { "id": "authors:rrbtr-b3054", "collection": "authors", "collection_id": "rrbtr-b3054", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20171222-081322902", "type": "book_section", "title": "A vacuum capillary viscometer that measures the viscosity of biofluids", "book_title": "2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS)", "author": [ { "family_name": "Chou", "given_name": "Tzu-Chieh", "orcid": "0000-0002-6074-8286", "clpid": "Chou-Tzu-Chieh" }, { "family_name": "Lee", "given_name": "Juhyun", "clpid": "Lee-Juhyun" }, { "family_name": "Hsiai", "given_name": "Tzung K.", "orcid": "0000-0003-1734-0792", "clpid": "Hsiai-Tzung-K" }, { "family_name": "Tai", "given_name": "Yu-Chong", "orcid": "0000-0001-8529-106X", "clpid": "Tai-Yu-Chong" } ], "abstract": "This paper reports a novel vacuum capillary viscometer featuring small sample volume (1 to 4 \u03bcL) and fast turnaround time (less than 30seconds), which allows for the first time, repeatable blood and plasma viscosity measurements from adult zebrafish.", "doi": "10.1109/TRANSDUCERS.2017.7994355", "isbn": "978-1-5386-2732-7", "publisher": "IEEE", "place_of_publication": "Piscataway, NJ", "publication_date": "2017-06", "pages": "1547-1550" }, { "id": "authors:vt2n0-2fa38", "collection": "authors", "collection_id": "vt2n0-2fa38", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20161013-093518415", "type": "book_section", "title": "In-vivo intravascular intervention with parylene micro-electrode to diagnose rupture-prone atherosclerotic plaque using electrical impedance spectroscopy", "book_title": "29th International Conference on Micro Electro Mechanical Systems (MEMS), 2016", "author": [ { "family_name": "Luo", "given_name": "Y.", "clpid": "Luo-Yuan" }, { "family_name": "Zhang", "given_name": "Xiaoxiao", "clpid": "Zhang-Xiaoxiao" }, { "family_name": "Packard", "given_name": "Rene", "orcid": "0000-0002-8520-5843", "clpid": "Packard-R-R-S" }, { "family_name": "Rongsong", "given_name": "Li", "clpid": "Rongsong-Li" }, { "family_name": "Hsiai", "given_name": "Tzung K.", "orcid": "0000-0003-1734-0792", "clpid": "Hsiai-Tzung-K" }, { "family_name": "Liu", "given_name": "Yang", "orcid": "0000-0002-8155-9134", "clpid": "Liu-Yang" }, { "family_name": "Tai", "given_name": "Yu-Chong", "orcid": "0000-0001-8529-106X", "clpid": "Tai-Yu-Chong" } ], "abstract": "It is of great clinical interest to have easy and reliable diagnostic techniques to localize and identify vulnerable plaques. Here, an in-vivo, catheter-integrated and balloon-mounted Parylene-C micro electrode impedance sensor was developed for intra-vascular interrogation of atherosclerotic vulnerable plaques using Electrical Impedance spectroscopy (EIS). Successful in vivo experiments of the EIS device were demonstrated using high-fat-dieted New Zealand rabbits. The results showed that electrical impedance spectroscopy (EIS) with micro parylene electrodes is promising to distinguish unstable plaques.", "doi": "10.1109/MEMSYS.2016.7421621", "isbn": "978-1-5090-1973-1", "publisher": "IEEE", "place_of_publication": "Piscataway, NJ", "publication_date": "2016-01", "pages": "307-310" }, { "id": "authors:s8tst-6p776", "collection": "authors", "collection_id": "s8tst-6p776", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20160826-105504418", "type": "book_section", "title": "Measurement of viscosity of adult zebrafish blood using a capillary pressure-driven viscometer", "book_title": "18th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS)", "author": [ { "family_name": "Kang", "given_name": "D.", "clpid": "Kang-D" }, { "family_name": "Wang", "given_name": "W.", "clpid": "Wang-W" }, { "family_name": "Lee", "given_name": "J.", "clpid": "Lee-J" }, { "family_name": "Tai", "given_name": "Y. C.", "orcid": "0000-0001-8529-106X", "clpid": "Tai-Yu-Chong" }, { "family_name": "Hsiai", "given_name": "T. K.", "orcid": "0000-0003-1734-0792", "clpid": "Hsiai-Tzung-K" } ], "abstract": "This paper presents the first experimental work on the viscosity measurement of adult zebrafish whole blood using a capillary pressure-driven microfluidic viscometer. After the device calibration with water, the viscosity measurement of human whole blood was performed and in good agreement with published data, demonstrating the reliability of the device. Power law and Carreau-Yasuda rheological models were used to model the non-Newtonian behaviors of the human and zebrafish blood. Theoretical modeling and numerical algorithms were applied to determine the blood viscosity over a wide range of shear rates. The proposed approach is uniquely applicable for small sample volume (down to 1\u03bcL or less), and short measurement time (<3min). A wide range of shear rates is produced in a single test.", "doi": "10.1109/TRANSDUCERS.2015.7181261", "isbn": "978-1-4799-8955-3", "publisher": "IEEE", "place_of_publication": "Piscataway, NJ", "publication_date": "2015-06", "pages": "1661-1664" }, { "id": "authors:yzfkj-g9w49", "collection": "authors", "collection_id": "yzfkj-g9w49", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20160318-083235523", "type": "book_section", "title": "A Wireless EeG Recording System for Small Animal Models of Heart Regeneration", "book_title": "2015 IEEE MTT-S International Microwave Symposium", "author": [ { "family_name": "Cao", "given_name": "Hung", "clpid": "Cao-Hung" }, { "family_name": "Zhao", "given_name": "Yu", "clpid": "Zhao-Yu" }, { "family_name": "Kouki", "given_name": "Ammar B.", "clpid": "Kouki-A-B" }, { "family_name": "Tai", "given_name": "Yu-Chong", "orcid": "0000-0001-8529-106X", "clpid": "Tai-Yu-Chong" }, { "family_name": "Hsiai", "given_name": "Tzung K.", "orcid": "0000-0003-1734-0792", "clpid": "Hsiai-Tzung-K" } ], "abstract": "Heart failure afflicts the developed world, causing mortality more than any other diseases. This is due to the fact that humans' heart possesses a very limited capacity to regenerate. Heart attacks or myocardial infarction (MI) could result in an irreversible loss of cardiomyocytes and consequently heart failure. Besides, zebrafish and neonatal mice are well-known for their magical capacity to recover after ventricular amputation, thus becoming precious models for heart regeneration studies. In this work, we report the first wireless electrocardiography (ECG) recording system for small animal models of heart regeneration. The system consists of a microelectrode array (MEA) and electronic components for wireless powering, signal processing and data communication. The MEA is based on a biocompatible and flexible polymer so it could conform to non-planar anatomical surfaces. The power transfer is achieved using inductive coupling between two solenoids and the ECG signals are sent through an optical link. The wireless operation can free the animal, eliminating anesthesia during experiments and thus minimizing unwanted side effects. The first generation of the device was demonstrated successfully with neonatal mice, revealing awake ECG signals with all features, thereby paving the way to physiologically investigate heart regeneration in long-term without disrupting the animals' normal activities.", "doi": "10.1109/MWSYM.2015.7167081", "isbn": "978-1-4799-8275-2", "publisher": "IEEE", "place_of_publication": "Piscataway, NJ", "publication_date": "2015-05", "pages": "1-3" }, { "id": "authors:vpg4b-pbv63", "collection": "authors", "collection_id": "vpg4b-pbv63", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20150717-124510753", "type": "book_section", "title": "Measurement of viscosity of unadulterated human whole blood using a capillary pressure-driven viscometer", "author": [ { "family_name": "Kang", "given_name": "Dongyang", "clpid": "Kang-Dongyang" }, { "family_name": "Wang", "given_name": "Wei", "orcid": "0000-0002-5257-7675", "clpid": "Wang-Wei" }, { "family_name": "Lee", "given_name": "Juhyun", "clpid": "Lee-Juhyun" }, { "family_name": "Tai", "given_name": "Yu-Chong", "orcid": "0000-0001-8529-106X", "clpid": "Tai-Yu-Chong" }, { "family_name": "Hsiai", "given_name": "Tzung K.", "orcid": "0000-0003-1734-0792", "clpid": "Hsiai-Tzung-K" } ], "abstract": "This paper presents the experimental work on the measurement of unadulterated human whole blood viscosity using a capillary-based microfluidic viscometer. The viscosity was measured by monitoring the time-varying length and mean advancing velocity of the blood column inside the viscometer. A high-aspect-ratio microfluidic channel is preferred for the device geometrical configuration. Theoretical modeling and numerical algorithms were applied to obtain the blood viscosity over a wide range of shear rates. Power law and Carreau-Yasuda models were used to model the non-Newtonian behavior of the human whole blood. The proposed approach is uniquely applicable for small sample volume (<2\u00b5L), and short measurement time (<2 min). A wide range of shear rates (varying from of 71.4s^(\u22121) to 5492.1s^(\u22121)) is produced in a single test.", "doi": "10.1109/NEMS.2015.7147343", "publisher": "IEEE", "publication_date": "2015-04" }, { "id": "authors:72t28-3q705", "collection": "authors", "collection_id": "72t28-3q705", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20150722-080523739", "type": "book_section", "title": "Flexible micro sensor for intravascular vulnerable plaque diagnostic with electrical impedance spectroscopy", "author": [ { "family_name": "Zhang", "given_name": "Xiaoxiao", "clpid": "Zhang-Xiaoxiao" }, { "family_name": "Xu", "given_name": "Lei", "clpid": "Xu-Lei" }, { "family_name": "Lee", "given_name": "Juhyun", "clpid": "Lee-Juhyun" }, { "family_name": "Li", "given_name": "Rongsong", "clpid": "Li-Rongsong" }, { "family_name": "Liu", "given_name": "Yang", "orcid": "0000-0002-8155-9134", "clpid": "Liu-Yang" }, { "family_name": "Shapero", "given_name": "Aubrey", "clpid": "Shapero-A-M" }, { "family_name": "Hsiai", "given_name": "Tzung K.", "orcid": "0000-0003-1734-0792", "clpid": "Hsiai-Tzung-K" }, { "family_name": "Tai", "given_name": "Yu-Chong", "orcid": "0000-0001-8529-106X", "clpid": "Tai-Yu-Chong" } ], "abstract": "Studies have shown emerging evidence that rupture of coronary plaque containing a lipid-rich core with subsequent thrombus formation is the most frequent mechanism by which atherosclerosis leads to the acute ischaemic syndromes of unstable angina, acute myocardial infarction, and often times, sudden cardiac death. However, since the lumen is not significantly blocked in these cases, such \"vulnerable\" plaques show noncritical stenosis in X-ray angiography and Intravascular Ultrasound (IVUS), tools currently available to diagnose coronary artery disease. The ability to distinguish such rupture-prone vulnerable plaques remains largely lacking. Therefore it is of great clinical interest to find improved diagnostic techniques to identify and localize such rupture-prone plaques. On the other hand, lipid has significantly lower electrical impedance than the rest of the vessel components in certain frequency bands [1]. We show in this paper that electrical impedance spectroscopy (EIS) technique can be useful to effectively distinguish plaques with such lipid cores. We include in this paper the design rationale of a four electrode EIS sensor and the measurement results between 1 Hz to 300 KHz of ex-vivo mouse aortas with plaque lesions. The impedance modulus over 200 Hz-100 KHz show consistent elevated values 2-5 times higher than their proximity control sites in all three individual mice. The promising ex-vivo EIS results show promising potential for a reliable unstable plaque diagnostic tool for in-vivo catheter integrated intravascular micro EIS sensors.", "doi": "10.1109/NEMS.2015.7147419", "publisher": "IEEE", "publication_date": "2015-04" }, { "id": "authors:q64ax-k0w63", "collection": "authors", "collection_id": "q64ax-k0w63", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20160317-144512824", "type": "book_section", "title": "Wearable flexible micro electrode for adult zebrafish long term ecgmonitoring", "book_title": "28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2015)", "author": [ { "family_name": "Zhang", "given_name": "Xiaoxiao", "clpid": "Zhang-Xiaoxiao" }, { "family_name": "Beebe", "given_name": "Tyler", "clpid": "Beebe-T" }, { "family_name": "Liu", "given_name": "Yang", "orcid": "0000-0002-8155-9134", "clpid": "Liu-Yang" }, { "family_name": "Park", "given_name": "Jungwook", "clpid": "Park-Jungwook" }, { "family_name": "Hsiai", "given_name": "Tzung K.", "orcid": "0000-0003-1734-0792", "clpid": "Hsiai-Tzung-K" }, { "family_name": "Tai", "given_name": "Yu-Chong", "orcid": "0000-0001-8529-106X", "clpid": "Tai-Yu-Chong" } ], "abstract": "During the last decade, close resemblance between the zebrafish heart and human heart physiology has been discovered [1] andzebrafish (Danio rerio) has become an emerging animal model for studying side effects developmental drugs may impose on the heart [2][3]. More interestingly, contrary to human heart the zebrafish heart has a remarkable ability to \"regenerate\" after severe injury [4], making it also a popular model for studies of regenerative medicine. On the other hand, Electrocardiogram (ECG) is a widely used tool to monitor the physiological changes of the zebrafish heart. However, due to its in-water habitat, a long term ECG monitoring solution, although very much needed, was not present. All published adult zebrafish ECG recorded to this date have been done acutely with anesthetized fish. This work presents, for the first time a wearable flexible parylene (PA) micro-electrode that monitors the Adult Zebrafish ECG long term. We show here the design, fabrication and testing of the flexible electrode along with a micro-molded ultra-soft, density adjusted silicone jacket, allowing ECG recording to be carried under water, in the fish's natural habitat with no need for anesthesia.", "doi": "10.1109/MEMSYS.2015.7051051", "isbn": "978-1-4799-7955-4", "publisher": "IEEE", "place_of_publication": "Piscataway, NJ", "publication_date": "2015-01", "pages": "690-693" }, { "id": "authors:dfpgz-gmq53", "collection": "authors", "collection_id": "dfpgz-gmq53", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20140520-134501570", "type": "book_section", "title": "A wearable percutaneous implant for long term zebrafish epicardial ECG recording", "book_title": "2013 Transducers & Eurosensors XXVII", "author": [ { "family_name": "Zhao", "given_name": "Yu", "clpid": "Zhao-Yu" }, { "family_name": "Yu", "given_name": "Fei", "clpid": "Yu-Fei" }, { "family_name": "Cao", "given_name": "Hung", "clpid": "Cao-Hung" }, { "family_name": "Chang", "given_name": "Honglong", "clpid": "Chang-Honglong" }, { "family_name": "Zhang", "given_name": "Xiaoxiao", "clpid": "Zhang-Xiaoxiao" }, { "family_name": "Hsiai", "given_name": "Tzung K.", "orcid": "0000-0003-1734-0792", "clpid": "Hsiai-Tzung-K" }, { "family_name": "Tai", "given_name": "Yu-Chong", "orcid": "0000-0001-8529-106X", "clpid": "Tai-Yu-Chong" } ], "abstract": "Heart, as the least regenerative organ in human, can regenerate in zebrafish even after up to 20% ventricle amputation without forming any scar tissue. The Electrocardiogram (ECG) recorded from multiple fixed locations around the heart with high spatial resolution can elucidate changes in cardiac electric phenotypes of injured and regenerating tissues. Therefore, a wearable zebrafish harness with a percutaneous planar electrode array was designed, fabricated and properly positioned to uncover the electrical conduction phenotypes during the zebrafish heart regeneration. The recording circuitry and data processing have also been developed and customized, paving the way to the future underwater wireless long-term ECG recording in real time.", "doi": "10.1109/Transducers.2013.6626876", "isbn": "9781467359818", "publisher": "IEEE", "place_of_publication": "Piscataway, NJ", "publication_date": "2013-06", "pages": "756-759" } ]