Hay, Bruce A.

• Hay, Bruce A. and Guo, Ming (2022) Gene drive-mediated population elimination for biodiversity conservation. When you come to a fork in the road, take it; Proceedings of the National Academy of Sciences of the United States of America; Vol. 119; No. 51; Art. No. e2218020119; PMCID PMC9907123; 10.1073/pnas.2218020119
• Yang, Huan; Sibilla, Caroline; et el. (2022) Clueless/CLUH regulates mitochondrial fission by promoting recruitment of Drp1 to mitochondria; Nature Communications; Vol. 13; No. 1; Art. No. 1582; 10.1038/s41467-022-29071-4
• Oberhofer, Georg; Ivy, Tobin; et el. (2021) Gene drive that results in addiction to a temperature-sensitive version of an essential gene triggers population collapse in Drosophila; Proceedings of the National Academy of Sciences; Vol. 118; No. 49; Art. No. e2107413118; PMCID PMC8670509; 10.1073/pnas.2107413118
• Oberhofer, Georg; Ivy, Tobin; et el. (2021) Split versions of Cleave and Rescue selfish genetic elements for measured self limiting gene drive; PLoS Genetics; Vol. 17; No. 2; Art. No. e1009385; 10.1371/journal.pgen.1009385
• Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; et el. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition); Autophagy; Vol. 17; No. 1; 1-382; 10.1080/15548627.2020.1797280
• Hay, Bruce A.; Oberhofer, Georg; et el. (2021) Engineering the Composition and Fate of Wild Populations with Gene Drive; Annual Review of Entomology; Vol. 66; 407-434; 10.1146/annurev-ento-020117-043154
• Zhang, Ting; Hay, Bruce A.; et el. (2020) Generation, Analyzing and in-vivo Drug Treatment of Drosophila Models with IBMPFD; Bio-protocol; Vol. 10; No. 10; Art. No. e3621; PMCID PMC7842768; 10.21769/bioprotoc.3621
• Kandul, Nikolay P.; Liu, Junru; et el. (2020) A drug-inducible sex-separation technique for insects; Nature Communications; Vol. 11; Art. No. 2106; PMCID PMC7193620; 10.1038/s41467-020-16020-2
• Oberhofer, Georg; Ivy, Tobin; et el. (2020) Gene drive and resilience through renewal with next generation Cleave and Rescue selfish genetic elements; Proceedings of the National Academy of Sciences of the United States of America; Vol. 117; No. 16; 9013-9021; PMCID PMC7183144; 10.1073/pnas.1921698117
• Oberhofer, Georg; Ivy, Tobin; et el. (2019) Cleave and Rescue, a novel selfish genetic element and general strategy for gene drive; Proceedings of the National Academy of Sciences of the United States of America; Vol. 116; No. 13; 6250-6259; PMCID PMC6442612; 10.1073/pnas.1816928116
• Oberhofer, Georg; Ivy, Tobin; et el. (2018) Behavior of homing endonuclease gene drives targeting genes required for viability or female fertility with multiplexed guide RNAs; Proceedings of the National Academy of Sciences of the United States of America; Vol. 115; No. 40; E9343-E9352; PMCID PMC6176634; 10.1073/pnas.1805278115
• Buchman, Anna B.; Ivy, Tobin; et el. (2018) Engineered Reciprocal Chromosome Translocations Drive High Threshold, Reversible Population Replacement in Drosophila; ACS Synthetic Biology; Vol. 7; No. 5; 1359-1370; 10.1021/acssynbio.7b00451
• Hay, Bruce A.; Li, Juan; et el. (2018) Vectored gene delivery for lifetime animal contraception: Overview and hurdles to implementation; Theriogenology; Vol. 112; 63-74; 10.1016/j.theriogenology.2017.11.003
• Adelman, Zach and Hay, Bruce A. (2017) Rules of the road for insect gene drive research and testing; Nature Biotechnology; Vol. 35; No. 8; 716-718; PMCID PMC5831321; 10.1038/nbt.3926
• Kandul, Nikolay; Guo, Ming; et el. (2017) A positive readout single transcript reporter for site-specific mRNA cleavage; PeerJ; Vol. 5; Art. No. e3602; PMCID PMC5522606; 10.7717/peerj.3602
• Zhang, Ting; Mishra, Prashant; et el. (2017) Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutants; eLife; Vol. 6; Art. No. e17834; PMCID PMC5360448; 10.7554/eLife.17834
• Kandul, Nikolay P.; Zhang, Ting; et el. (2016) Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila; Nature Communications; Vol. 7; Art. No. 13100; PMCID PMC5114534; 10.1038/ncomms13100
• Choi, Harry M. T.; Calvert, Colby R.; et el. (2016) Mapping a multiplexed zoo of mRNA expression; Development; Vol. 143; No. 19; 3632-3637; PMCID PMC5087610; 10.1242/dev.140137
• Ferree, Patrick M.; Fang, Christopher; et el. (2015) Identification of Genes Uniquely Expressed in the Germ Line Tissues of the Jewel Wasp Nasonia vitripennis; G3; Vol. 5; No. 12; 2647-2653; PMCID PMC4683638; 10.1534/g3.115.021386
• Li, Juan; Olvera, Alejandra I.; et el. (2015) Vectored antibody gene delivery mediates long-term contraception; Current Biology; Vol. 25; No. 19; R820-R822; 10.1016/j.cub.2015.08.002
• Akbari, Omar S.; Chen, Chun-Hong; et el. (2014) Novel Synthetic Medea Selfish Genetic Elements Drive Population Replacement in Drosophila; a Theoretical Exploration of Medea-Dependent Population Suppression; ACS Synthetic Biology; Vol. 3; No. 12; 915-928; PMCID PMC3742681; 10.1021/sb300079h
• Marshall, John M. and Hay, Bruce A. (2014) Medusa: A Novel Gene Drive System for Confined Suppression of Insect Populations; PLoS ONE; Vol. 9; No. 7; e102694; PMCID PMC4108329; 10.1371/journal.pone.0102694
• Akbari, Omar S.; Papathanos, Philippos A.; et el. (2014) Identification of germline transcriptional regulatory elements in Aedes aegypti; Scientific Reports; Vol. 4; Art. No. 3954; PMCID PMC3912481; 10.1038/srep03954
• Papathanos, Philippos A.; Akbari, Omar S.; et el. (2013) A Toolbox of Aedes Aegypti Germline Regulatory Elements for the Development of Genetic Drive Systems and Population Control; Pathogens and Global Health; Vol. 107; No. 8; 445; 10.1179/2047772413Z.000000000160
• Akbari, Omar; Marshall, John; et el. (2013) Engineering synthetic medea-based and threshold-dependent underdominance-based gene drive systems in mosquitos; Pathogens and Global Health; Vol. 107; No. 8; 442; 10.1179/2047772413Z.000000000160
• Marshall, John; White, Michael; et el. (2013) Mathematical insights into novel vector control strategies: from outdoor control to confineable transgenic systems; Pathogens and Global Health; Vol. 107; No. 8; 451; 10.1179/2047772413Z.000000000160
• Akbari, Omar S.; Amrhein, Henry; et el. (2013) The Developmental Transcriptome of the Mosquito Aedes aegypti, an Invasive Species and Major Arbovirus Vector; G3; Vol. 3; No. 9; 1493-1509; PMCID PMC3755910; 10.1534/g3.113.006742
• Akbari, Omar S.; Antoshechkin, Igor; et el. (2013) Transcriptome Profiling of Nasonia vitripennis Testis Reveals Novel Transcripts Expressed from the Selfish B Chromosome, Paternal Sex Ratio; G3; Vol. 3; No. 9; 1597-1605; PMCID PMC3755920; 10.1534/g3.113.007583
• Akbari, Omar S.; Matzen, Kelly D.; et el. (2013) A Synthetic Gene Drive System for Local, Reversible Modification and Suppression of Insect Populations; Current Biology; Vol. 23; No. 8; 671-677; PMCID PMC8459379; 10.1016/j.cub.2013.02.059
• Lee, Gyunghee; Sehgal, Ritika; et el. (2013) Essential role of grim-led programmed cell death for the establishment of corazonin-producing peptidergic nervous system during embryogenesis and metamorphosis in Drosophila melanogaster; Biology Open; Vol. 2; No. 3; 283-294; PMCID PMC3603410; 10.1242/bio.20133384
• Marshall, John M. and Hay, Bruce A. (2012) General principles of single-construct chromosomal gene drive; Evolution; Vol. 66; No. 7; 2150-2166; PMCID PMC3389707; 10.1111/j.1558-5646.2012.01582.x
• Marshall, John M. and Hay, Bruce A. (2012) Confinement of gene drive systems to local populations: A comparative analysis; Journal of Theoretical Biology; Vol. 294; 153-171; PMCID PMC3260013; 10.1016/j.jtbi.2011.10.032
• Rochet, Jean-Christophe; Hay, Bruce A.; et el. (2012) Molecular Insights into Parkinson’s Disease; ISBN 9780123858832; Molecular Biology of Neurodegenerative Diseases; Academic Press: Amsterdam; 125-188; 10.1016/B978-0-12-385883-2.00011-4
• Marshall, John M. and Hay, Bruce A. (2011) Inverse Medea as a Novel Gene Drive System for Local Population Replacement: A Theoretical Analysis; Journal of Heredity; Vol. 102; No. 3; 336-341; PMCID PMC3076586; 10.1093/jhered/esr019
• Ward, Catherine M.; Su, Jessica T.; et el. (2011) Medea Selfish Genetic Elements as Tools for Altering Traits of Wild Populations: A Theoretical Analysis; Evolution; Vol. 65; No. 4; 1149-1162; PMCID PMC3601553; 10.1111/j.1558-5646.2010.01186.x
• Marshall, John M.; Pittman, Geoffrey W.; et el. (2011) Semele: A Killer-Male, Rescue-Female System for Suppression and Replacement of Insect Disease Vector Populations; Genetics; Vol. 187; No. 2; 535-551; PMCID PMC3030495; 10.1534/genetics.110.124479
• Lee, Gyunghee; Wang, Zixing; et el. (2011) Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis; Journal of Comparative Neurology; Vol. 519; No. 1; 34-48; 10.1002/cne.22498
• Hay, Bruce A.; Chen, Chun-Hong; et el. (2010) Engineering the genomes of wild insect populations: Challenges, and opportunities provided by synthetic Medea selfish genetic elements; Journal of Insect Physiology; Vol. 56; No. 10; 1402-1413; PMCID PMC3601555; 10.1016/j.jinsphys.2010.05.022
• Siegrist, Sarah E.; Haque, Najm S.; et el. (2010) Inactivation of Both foxo and reaper Promotes Long-Term Adult Neurogenesis in Drosophila; Current Biology; Vol. 20; No. 7; 643-648; PMCID PMC2862284; 10.1016/j.cub.2010.01.060
• Ribaya, Jeronimo P.; Ranmuthu, Madhuka; et el. (2009) The deubiquitinase emperor’s thumb is a regulator of apoptosis in Drosophila; Developmental Biology; Vol. 329; No. 1; 25-35; 10.1016/j.ydbio.2009.02.005
• Hawkins, Julie L.; Robbins, Michael D.; et el. (2008) Pharmacologic Inhibition of Site 1 Protease Activity Inhibits Sterol Regulatory Element-Binding Protein Processing and Reduces Lipogenic Enzyme Gene Expression and Lipid Synthesis in Cultured Cells and Experimental Animals; Journal of Pharmacology and Experimental Therapeutics; Vol. 326; No. 3; 801-808; 10.1124/jpet.108.139626
• Sathyanarayanan, Sriram; Zheng, Xiangzhong; et el. (2008) Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen; Genes and Development; Vol. 22; No. 11; 1522-1533; PMCID PMC2418588; 10.1101/gad.1652308
• Yao, Jih-Guang; Weasner, Bonnie M.; et el. (2008) Differential requirements for the Pax6(5a) genes eyegone and twin of eyegone during eye development in Drosophila; Developmental Biology; Vol. 315; No. 2; 535-551; PMCID PMC2702218; 10.1016/j.ydbio.2007.12.037
• Shcherbata, Halyna R.; Ward, Ellen J.; et el. (2007) Stage-specific differences in the requirements for germline stem cell maintenance in the Drosophila ovary; Cell Stem Cell; Vol. 1; No. 6; 698-709; PMCID PMC2211735; 10.1016/j.stem.2007.11.007
• Hay, Bruce A.; Abrams, Barbara; et el. (2007) Aminopyrrolidineamide inhibitors of site-1 protease; Bioorganic and Medicinal Chemistry Letters; Vol. 17; No. 16; 4411-4414; 10.1016/j.bmcl.2007.06.031
• Copeland, Jeffrey M.; Bosdet, Ian; et el. (2007) echinus, required for interommatidial cell sorting and cell death in the Drosophila pupal retina, encodes a protein with homology to ubiquitin-specific proteases; BMC Developmental Biology; Vol. 7; No. 82; PMCID PMC1950886; 10.1186/1471-213X-7-82
• Chen, Chun-Hong; Huang, Haixia; et el. (2007) A Synthetic Maternal-Effect Selfish Genetic Element Drives Population Replacement in Drosophila; Science; Vol. 316; No. 5824; 597-600; 10.1126/science. 1138595
• Huh, Jun R.; Foe, Ian; et el. (2007) The Drosophila Inhibitor of Apoptosis (IAP) DIAP2 Is Dispensable for Cell Survival, Required for the Innate Immune Response to Gram-negative Bacterial Infection, and Can Be Negatively Regulated by the Reaper/Hid/Grim Family of IAP-binding Apoptosis Inducers; Journal of Biological Chemistry; Vol. 282; No. 3; 2056-2068; 10.1074/jbc.M608051200
• Hay, Bruce A. and Guo, Ming (2006) Caspase-Dependent Cell Death in Drosophila; Annual Review of Cell and Developmental Biology; Vol. 22; 623-650; 10.1146/annurev.cellbio.21.012804.093845
• Chen, Chun-Hong; Guo, Ming; et el. (2006) Identifying MicroRNA Regulators of Cell Death in Drosophila; ISBN 978-1-58829-581-1; MicroRNA Protocols; Humana Press: Totowa, NJ; 229-240; 10.1385/1-59745-123-1:229
• Muro, Israel; Berry, Deborah L.; et el. (2006) The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process; Development; Vol. 133; No. 17; 3305-3315; 10.1242/dev.02495
• Clark, Ira E.; Dodson, Mark W.; et el. (2006) Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin; Nature; Vol. 441; No. 7097; 1162-1166; 10.1038/nature04779
• Yan, Nieng; Huh, Jun R.; et el. (2006) Structure and Activation Mechanism of the Drosophila Initiator Caspase Dronc; Journal of Biological Chemistry; Vol. 281; No. 13; 8667-8674; 10.1074/jbc.M513232200
• Xu, Peizhang; Guo, Ming; et el. (2004) MicroRNAs and the regulation of cell death; Trends in Genetics; Vol. 20; No. 12; 617-624; 10.1016/j.tig.2004.09.010
• Hay, Bruce A.; Huh, Jun R.; et el. (2004) The genetics of cell death: approaches, insights and opportunities in Drosophila; Nature Reviews. Genetics; Vol. 5; No. 12; 911-922; 10.1038/nrg1491
• Huh, Jun R.; Guo, Ming; et el. (2004) Compensatory Proliferation Induced by Cell Death in the Drosophila Wing Disc Requires Activity of the Apical Cell Death Caspase Dronc in a Nonapoptotic Role; Current Biology; Vol. 14; No. 14; 1262-1266; 10.1016/j.cub.2004.06.015
• Huh, Jun R.; Vernooy, Stephanie Y.; et el. (2004) Multiple Apoptotic Caspase Cascades Are Required in Nonapoptotic Roles for Drosophila Spermatid Individualization; PLoS Biology; Vol. 2; No. 1; 43-53; PMCID PMC300883; 10.1371/journal.pbio.0020015
• Chai, Jijie; Yan, Nieng; et el. (2003) Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination; Nature Structural Biology; Vol. 10; No. 11; 892-898; 10.1038/nsb989
• Guo, Ming; Hong, Elizabeth J.; et el. (2003) A reporter for amyloid precursor protein γ-secretase activity in Drosophila; Human Molecular Genetics; Vol. 12; No. 20; 2669-2678; 10.1093/hmg/ddg292
• Hay, Bruce A. and Guo, Ming (2003) Coupling Cell Growth, Proliferation, and Death: Hippo Weighs In; Developmental Cell; Vol. 5; No. 3; 361-363; 10.1016/s1534-5807(03)00270-3
• Xu, Peizhang; Vernooy, Stephanie Y.; et el. (2003) The Drosophila MicroRNA Mir-14 Suppresses Cell Death and Is Required for Normal Fat Metabolism; Current Biology; Vol. 13; No. 9; 790-795; 10.1016/s0960-9822(03)00250-1
• Olson, Michael R.; Holley, Christopher L.; et el. (2003) Reaper is regulated by IAP-mediated ubiquitination; Journal of Biological Chemistry; Vol. 278; No. 6; 4028-4034; 10.1074/jbc.M209734200
• Muro, Israel; Hay, Bruce A.; et el. (2002) The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC; Journal of Biological Chemistry; Vol. 277; No. 51; 49644-49650; 10.1074/jbc.M203464200
• Huh, Jun R. and Hay, Bruce A. (2002) Apoptosis - Sculpture of a fly’s head; Nature; Vol. 418; No. 6901; 926-928; 10.1038/418926a
• Vernooy, Stephanie Y.; Chow, Vivian; et el. (2002) Drosophila Bruce Can Potently Suppress Rpr- and Grim-Dependent but Not Hid-Dependent Cell Death; Current Biology; Vol. 12; No. 13; 1164-1168; 10.1016/s0960-9822(02)00935-1
• Yu, Sun-Yun; Yoo, Soon Ji; et el. (2002) A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye; Development; Vol. 129; No. 13; 3269-3278
• Yoo, Soon Ji; Huh, Jun R.; et el. (2002) Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms; Nature Cell Biology; Vol. 4; No. 6; 416-424; 10.1038/ncb793
• Dorstyn, Loretta; Read, Stuart; et el. (2002) The role of cytochrome c in caspase activation in Drosophila melanogaster cells; Journal of Cell Biology; Vol. 156; No. 6; 1089-1098; PMCID PMC2173478; 10.1083/jcb.200111107
• Hay, Bruce A.; Cole, Bridget M.; et el. (2001) Small molecule somatostatin receptor subtype-2 antagonists; Bioorganic and Medicinal Chemistry Letters; Vol. 11; No. 20; 2731-2734; 10.1016/s0960-894x(01)00568-6
• Wu, Jia-Wei; Cocina, Amy E.; et el. (2001) Structural Analysis of a Functional DIAP1 Fragment Bound to Grim and Hid Peptides; Molecular Cell; Vol. 8; No. 1; 95-104; 10.1016/s1097-2765(01)00282-9
• Hay, B. A. (2000) Understanding IAP function and regulation: a view from Drosophila; Cell Death and Differentiation; Vol. 7; No. 11; 1045-1056; 10.1038/sj.cdd.4400765
• Hawkins, Christine J.; Yoo, Soon Ji; et el. (2000) The Drosophila Caspase DRONC Cleaves following Glutamate or Aspartate and Is Regulated by DIAP1, HID, and GRIM; Journal of Biological Chemistry; Vol. 275; No. 35; 27084-27093; 10.1074/jbc.M000869200
• Vernooy, Stephanie Y.; Copeland, Jeffrey; et el. (2000) Cell death regulation in Drosophila: Conservation of mechanism and unique insights; Journal of Cell Biology; Vol. 150; No. 2; F69-F75; PMCID PMC2180229; 10.1083/jcb.150.2.F69
• Rubin, Gerald M. and Hay, Bruce A. (2000) Comparative Genomics of the Eukaryotes; Science; Vol. 287; No. 5461; 2204-2215; PMCID PMC2754258; 10.1126/science.287.5461.2204
• Hawkins, Christine J.; Wang, Susan L.; et el. (2000) Monitoring Activity of Caspases and Their Regulators in Yeast Saccharomyces cerevisiae; ISBN 9780121822231; Apoptosis; Academic Press: London; 162-174; 10.1016/s0076-6879(00)22016-8
• Guo, Ming and Hay, Bruce A. (1999) Cell proliferation and apoptosis; Current Opinion in Cell Biology; Vol. 11; No. 6; 745-752; 10.1016/s0955-0674(99)00046-0
• Wang, Susan L.; Hawkins, Christine J.; et el. (1999) The Drosophila Caspase Inhibitor DIAP1 Is Essential for Cell Survival and Is Negatively Regulated by HID; Cell; Vol. 98; No. 4; 453-463; 10.1016/S0092-8674(00)81974-1
• Hawkins, Christine J.; Wang, Susan L.; et el. (1999) A cloning method to identify caspases and their regulators in yeast: Identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1; Proceedings of the National Academy of Sciences of the United States of America; Vol. 96; No. 6; 2885-2890; PMCID PMC15864; 10.1073/pnas.96.6.2885
• Hay, Bruce A.; Maile, Randy; et el. (1997) P element insertion-dependent gene activation in the Drosophila eye; Proceedings of the National Academy of Sciences of the United States of America; Vol. 94; No. 10; 5195-5200; PMCID PMC24655; 10.1073/pnas.94.10.5195
• Hay, Bruce A.; Wassarman, David A.; et el. (1995) Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death; Cell; Vol. 83; No. 7; 1253-1262; 10.1016/0092-8674(95)90150-7
• Hay, Bruce A.; Wolff, Tanya; et el. (1994) Expression of baculovirus P35 prevents cell death in Drosophila; Development; Vol. 120; No. 8; 2121-2129
• Jongens, Thomas A.; Hay, Bruce; et el. (1992) The germ cell-less gene product: A posteriorly localized component necessary for germ cell development in Drosophila; Cell; Vol. 70; No. 4; 569-584; 10.1016/0092-8674(92)90427-e
• Hay, Bruce; Jan, Lily Yeh; et el. (1990) Localization of vasa, a component of Drosophila polar granules, in maternal-effect mutants that alter embryonic anteroposterior polarity; Development; Vol. 109; No. 2; 425-433
• Hay, Bruce; Jan, Lily Yeh; et el. (1988) A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases; Cell; Vol. 55; No. 4; 577-587; 10.1016/0092-8674(88)90216-4
• Hay, Bruce A.; Ackerman, Larry; et el. (1988) Identification of a component of Drosophila polar granules; Development; Vol. 103; No. 4; 625-640
• Hay, Bruce; Prusiner, Stanley B.; et el. (1987) Evidence for a secretory form of the cellular prion protein; Biochemistry; Vol. 26; No. 25; 8110-8115; 10.1021/bi00399a014
• McKinley, Michael P.; Hay, Bruce; et el. (1987) Developmental expression of prion protein gene in brain; Developmental Biology; Vol. 121; No. 1; 105-110; 10.1016/0012-1606(87)90143-6
• Hay, Bruce; Barry, Ronald A.; et el. (1987) Biogenesis and transmembrane orientation of the cellular isoform of the scrapie prion protein; Molecular and Cellular Biology; Vol. 7; No. 2; 914-920; PMCID PMC365150; 10.1128/mcb.7.2.914