Hay, Bruce A.; Guo, Ming (2022) Gene drive-mediated population elimination for biodiversity conservation. When you come to a fork in the road, take it Proceedings of the National Academy of Sciences of the United States of America; Vol. 119; No. 51;

Yang, Huan; Sibilla, Caroline et al. (2022) Clueless/CLUH regulates mitochondrial fission by promoting recruitment of Drp1 to mitochondria Nature Communications; Vol. 13; No. 1;

Oberhofer, Georg; Ivy, Tobin et al. (2021) Gene drive that results in addiction to a temperature-sensitive version of an essential gene triggers population collapse in Drosophila Proceedings of the National Academy of Sciences; Vol. 118; No. 49; Life 2.0: The Promise and Challenge of a CRISPR Path to a Sustainable Planet, 10-11 December 2019 , Irvine, CA

Oberhofer, Georg; Ivy, Tobin et al. (2021) Split versions of Cleave and Rescue selfish genetic elements for measured self limiting gene drive PLoS Genetics; Vol. 17; No. 2;

Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) Autophagy; Vol. 17; No. 1;

Hay, Bruce A.; Oberhofer, Georg et al. (2021) Engineering the Composition and Fate of Wild Populations with Gene Drive Annual Review of Entomology; Vol. 66;

Zhang, Ting; Hay, Bruce A. et al. (2020) Generation, Analyzing and in-vivo Drug Treatment of Drosophila Models with IBMPFD Bio-protocol; Vol. 10; No. 10;

Kandul, Nikolay P.; Liu, Junru et al. (2020) A drug-inducible sex-separation technique for insects Nature Communications; Vol. 11;

Oberhofer, Georg; Ivy, Tobin et al. (2020) Gene drive and resilience through renewal with next generation Cleave and Rescue selfish genetic elements Proceedings of the National Academy of Sciences of the United States of America; Vol. 117; No. 16;

Oberhofer, Georg; Ivy, Tobin et al. (2019) Cleave and Rescue, a novel selfish genetic element and general strategy for gene drive Proceedings of the National Academy of Sciences of the United States of America; Vol. 116; No. 13;

Oberhofer, Georg; Ivy, Tobin et al. (2018) Behavior of homing endonuclease gene drives targeting genes required for viability or female fertility with multiplexed guide RNAs Behavior of homing endonuclease gene drives targeting genes required for viability or female fertility with multiplexed guide RNAs; Proceedings of the National Academy of Sciences of the United States of America; Vol. 115; No. 40;

Buchman, Anna B.; Ivy, Tobin et al. (2018) Engineered Reciprocal Chromosome Translocations Drive High Threshold, Reversible Population Replacement in Drosophila ACS Synthetic Biology; Vol. 7; No. 5;

Hay, Bruce A.; Li, Juan et al. (2018) Vectored gene delivery for lifetime animal contraception: Overview and hurdles to implementation Theriogenology; Vol. 112;

Adelman, Zach; Hay, Bruce A. (2017) Rules of the road for insect gene drive research and testing Nature Biotechnology; Vol. 35; No. 8;

Kandul, Nikolay; Guo, Ming et al. (2017) A positive readout single transcript reporter for site-specific mRNA cleavage PeerJ; Vol. 5;

Zhang, Ting; Mishra, Prashant et al. (2017) Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutants eLife; Vol. 6;

Kandul, Nikolay P.; Zhang, Ting et al. (2016) Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila Nature Communications; Vol. 7;

Choi, Harry M. T.; Calvert, Colby R. et al. (2016) Mapping a multiplexed zoo of mRNA expression Development; Vol. 143; No. 19;

Ferree, Patrick M.; Fang, Christopher et al. (2015) Identification of Genes Uniquely Expressed in the Germ Line Tissues of the Jewel Wasp Nasonia vitripennis G3; Vol. 5; No. 12;

Li, Juan; Olvera, Alejandra I. et al. (2015) Vectored antibody gene delivery mediates long-term contraception Current Biology; Vol. 25; No. 19;

Akbari, Omar S.; Chen, Chun-Hong et al. (2014) Novel Synthetic Medea Selfish Genetic Elements Drive Population Replacement in Drosophila; a Theoretical Exploration of Medea-Dependent Population Suppression ACS Synthetic Biology; Vol. 3; No. 12;

Marshall, John M.; Hay, Bruce A. (2014) Medusa: A Novel Gene Drive System for Confined Suppression of Insect Populations PLoS ONE; Vol. 9; No. 7;

Akbari, Omar S.; Papathanos, Philippos A. et al. (2014) Identification of germline transcriptional regulatory elements in Aedes aegypti Scientific Reports; Vol. 4;

Papathanos, Philippos A.; Akbari, Omar S. et al. (2013) A Toolbox of Aedes Aegypti Germline Regulatory Elements for the Development of Genetic Drive Systems and Population Control Pathogens and Global Health; Vol. 107; No. 8; EMBO Conference on Molecular and Population Biology of Mosquitoes and Other Disease Vectors: From Basic Vector Biology to Disease Control, 15-19 July 2013 , Kolymbari, Greece

Akbari, Omar; Marshall, John et al. (2013) Engineering synthetic medea-based and threshold-dependent underdominance-based gene drive systems in mosquitos Pathogens and Global Health; Vol. 107; No. 8; EMBO Conference on Molecular and Population Biology of Mosquitoes and Other Disease Vectors: From Basic Vector Biology to Disease Control, 15-19 July 2013 , Kolymbari, Greece

Marshall, John; White, Michael et al. (2013) Mathematical insights into novel vector control strategies: from outdoor control to confineable transgenic systems Pathogens and Global Health; Vol. 107; No. 8; EMBO Conference on Molecular and Population Biology of Mosquitoes and Other Disease Vectors: From Basic Vector Biology to Disease Control, 15-19 July 2013 , Kolymbari, Greece

Akbari, Omar S.; Amrhein, Henry et al. (2013) The Developmental Transcriptome of the Mosquito Aedes aegypti, an Invasive Species and Major Arbovirus Vector G3; Vol. 3; No. 9;

Akbari, Omar S.; Antoshechkin, Igor et al. (2013) Transcriptome Profiling of Nasonia vitripennis Testis Reveals Novel Transcripts Expressed from the Selfish B Chromosome, Paternal Sex Ratio G3; Vol. 3; No. 9;

Akbari, Omar S.; Matzen, Kelly D. et al. (2013) A Synthetic Gene Drive System for Local, Reversible Modification and Suppression of Insect Populations Current Biology; Vol. 23; No. 8;

Lee, Gyunghee; Sehgal, Ritika et al. (2013) Essential role of grim-led programmed cell death for the establishment of corazonin-producing peptidergic nervous system during embryogenesis and metamorphosis in Drosophila melanogaster Biology Open; Vol. 2; No. 3;

Marshall, John M.; Hay, Bruce A. (2012) General principles of single-construct chromosomal gene drive Evolution; Vol. 66; No. 7;

Marshall, John M.; Hay, Bruce A. (2012) Confinement of gene drive systems to local populations: A comparative analysis Journal of Theoretical Biology; Vol. 294;

Marshall, John M.; Hay, Bruce A. (2011) Inverse Medea as a Novel Gene Drive System for Local Population Replacement: A Theoretical Analysis Journal of Heredity; Vol. 102; No. 3;

Ward, Catherine M.; Su, Jessica T. et al. (2011) Medea Selfish Genetic Elements as Tools for Altering Traits of Wild Populations: A Theoretical Analysis Evolution; Vol. 65; No. 4;

Marshall, John M.; Pittman, Geoffrey W. et al. (2011) Semele: A Killer-Male, Rescue-Female System for Suppression and Replacement of Insect Disease Vector Populations Genetics; Vol. 187; No. 2;

Lee, Gyunghee; Wang, Zixing et al. (2011) Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis Journal of Comparative Neurology; Vol. 519; No. 1;

Hay, Bruce A.; Chen, Chun-Hong et al. (2010) Engineering the genomes of wild insect populations: Challenges, and opportunities provided by synthetic Medea selfish genetic elements Journal of Insect Physiology; Vol. 56; No. 10;

Siegrist, Sarah E.; Haque, Najm S. et al. (2010) Inactivation of Both foxo and reaper Promotes Long-Term Adult Neurogenesis in Drosophila Current Biology; Vol. 20; No. 7;

Ribaya, Jeronimo P.; Ranmuthu, Madhuka et al. (2009) The deubiquitinase emperor's thumb is a regulator of apoptosis in Drosophila Developmental Biology; Vol. 329; No. 1;

Hawkins, Julie L.; Robbins, Michael D. et al. (2008) Pharmacologic Inhibition of Site 1 Protease Activity Inhibits Sterol Regulatory Element-Binding Protein Processing and Reduces Lipogenic Enzyme Gene Expression and Lipid Synthesis in Cultured Cells and Experimental Animals Journal of Pharmacology and Experimental Therapeutics; Vol. 326; No. 3;

Sathyanarayanan, Sriram; Zheng, Xiangzhong et al. (2008) Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen Genes and Development; Vol. 22; No. 11;

Yao, Jih-Guang; Weasner, Bonnie M. et al. (2008) Differential requirements for the Pax6(5a) genes eyegone and twin of eyegone during eye development in Drosophila Developmental Biology; Vol. 315; No. 2;

Shcherbata, Halyna R.; Ward, Ellen J. et al. (2007) Stage-specific differences in the requirements for germline stem cell maintenance in the Drosophila ovary Cell Stem Cell; Vol. 1; No. 6;

Hay, Bruce A.; Abrams, Barbara et al. (2007) Aminopyrrolidineamide inhibitors of site-1 protease Bioorganic and Medicinal Chemistry Letters; Vol. 17; No. 16;

Copeland, Jeffrey M.; Bosdet, Ian et al. (2007) echinus, required for interommatidial cell sorting and cell death in the Drosophila pupal retina, encodes a protein with homology to ubiquitin-specific proteases BMC Developmental Biology; Vol. 7; No. 82;

Chen, Chun-Hong; Huang, Haixia et al. (2007) A Synthetic Maternal-Effect Selfish Genetic Element Drives Population Replacement in Drosophila Science; Vol. 316; No. 5824;

Huh, Jun R.; Foe, Ian et al. (2007) The Drosophila Inhibitor of Apoptosis (IAP) DIAP2 Is Dispensable for Cell Survival, Required for the Innate Immune Response to Gram-negative Bacterial Infection, and Can Be Negatively Regulated by the Reaper/Hid/Grim Family of IAP-binding Apoptosis Inducers Journal of Biological Chemistry; Vol. 282; No. 3;

Hay, Bruce A.; Guo, Ming (2006) Caspase-Dependent Cell Death in Drosophila Annual Review of Cell and Developmental Biology; Vol. 22;

Muro, Israel; Berry, Deborah L. et al. (2006) The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process Development; Vol. 133; No. 17;

Clark, Ira E.; Dodson, Mark W. et al. (2006) Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin Nature; Vol. 441; No. 7097;

Yan, Nieng; Huh, Jun R. et al. (2006) Structure and Activation Mechanism of the Drosophila Initiator Caspase Dronc Journal of Biological Chemistry; Vol. 281; No. 13;

Xu, Peizhang; Guo, Ming et al. (2004) MicroRNAs and the regulation of cell death Trends in Genetics; Vol. 20; No. 12;

Hay, Bruce A.; Huh, Jun R. et al. (2004) The genetics of cell death: approaches, insights and opportunities in Drosophila Nature Reviews. Genetics; Vol. 5; No. 12;

Huh, Jun R.; Guo, Ming et al. (2004) Compensatory Proliferation Induced by Cell Death in the Drosophila Wing Disc Requires Activity of the Apical Cell Death Caspase Dronc in a Nonapoptotic Role Current Biology; Vol. 14; No. 14;

Huh, Jun R.; Vernooy, Stephanie Y. et al. (2004) Multiple Apoptotic Caspase Cascades Are Required in Nonapoptotic Roles for Drosophila Spermatid Individualization PLoS Biology; Vol. 2; No. 1;

Chai, Jijie; Yan, Nieng et al. (2003) Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination Nature Structural Biology; Vol. 10; No. 11;

Guo, Ming; Hong, Elizabeth J. et al. (2003) A reporter for amyloid precursor protein γ-secretase activity in Drosophila Human Molecular Genetics; Vol. 12; No. 20;

Hay, Bruce A.; Guo, Ming (2003) Coupling Cell Growth, Proliferation, and Death: Hippo Weighs In Developmental Cell; Vol. 5; No. 3;

Xu, Peizhang; Vernooy, Stephanie Y. et al. (2003) The Drosophila MicroRNA Mir-14 Suppresses Cell Death and Is Required for Normal Fat Metabolism Current Biology; Vol. 13; No. 9;

Olson, Michael R.; Holley, Christopher L. et al. (2003) Reaper is regulated by IAP-mediated ubiquitination Journal of Biological Chemistry; Vol. 278; No. 6;

Muro, Israel; Hay, Bruce A. et al. (2002) The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC Journal of Biological Chemistry; Vol. 277; No. 51;

Huh, Jun R.; Hay, Bruce A. (2002) Apoptosis - Sculpture of a fly's head Nature; Vol. 418; No. 6901;

Vernooy, Stephanie Y.; Chow, Vivian et al. (2002) Drosophila Bruce Can Potently Suppress Rpr- and Grim-Dependent but Not Hid-Dependent Cell Death Current Biology; Vol. 12; No. 13;

Yu, Sun-Yun; Yoo, Soon Ji et al. (2002) A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye Development; Vol. 129; No. 13;

Yoo, Soon Ji; Huh, Jun R. et al. (2002) Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms Nature Cell Biology; Vol. 4; No. 6;

Dorstyn, Loretta; Read, Stuart et al. (2002) The role of cytochrome c in caspase activation in Drosophila melanogaster cells Journal of Cell Biology; Vol. 156; No. 6;

Hay, Bruce A.; Cole, Bridget M. et al. (2001) Small molecule somatostatin receptor subtype-2 antagonists Bioorganic and Medicinal Chemistry Letters; Vol. 11; No. 20;

Wu, Jia-Wei; Cocina, Amy E. et al. (2001) Structural Analysis of a Functional DIAP1 Fragment Bound to Grim and Hid Peptides Molecular Cell; Vol. 8; No. 1;

Hay, B. A. (2000) Understanding IAP function and regulation: a view from Drosophila Cell Death and Differentiation; Vol. 7; No. 11;

Hawkins, Christine J.; Yoo, Soon Ji et al. (2000) The Drosophila Caspase DRONC Cleaves following Glutamate or Aspartate and Is Regulated by DIAP1, HID, and GRIM Journal of Biological Chemistry; Vol. 275; No. 35;

Vernooy, Stephanie Y.; Copeland, Jeffrey et al. (2000) Cell death regulation in Drosophila: Conservation of mechanism and unique insights Journal of Cell Biology; Vol. 150; No. 2;

Rubin, Gerald M.; Hay, Bruce A. (2000) Comparative Genomics of the Eukaryotes Science; Vol. 287; No. 5461;

Guo, Ming; Hay, Bruce A. (1999) Cell proliferation and apoptosis Current Opinion in Cell Biology; Vol. 11; No. 6;

Wang, Susan L.; Hawkins, Christine J. et al. (1999) The Drosophila Caspase Inhibitor DIAP1 Is Essential for Cell Survival and Is Negatively Regulated by HID Cell; Vol. 98; No. 4;

Hawkins, Christine J.; Wang, Susan L. et al. (1999) A cloning method to identify caspases and their regulators in yeast: Identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1 Proceedings of the National Academy of Sciences of the United States of America; Vol. 96; No. 6;

Hay, Bruce A.; Maile, Randy et al. (1997) P element insertion-dependent gene activation in the Drosophila eye Proceedings of the National Academy of Sciences of the United States of America; Vol. 94; No. 10;

Hay, Bruce A.; Wassarman, David A. et al. (1995) Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death Cell; Vol. 83; No. 7;

Hay, Bruce A.; Wolff, Tanya et al. (1994) Expression of baculovirus P35 prevents cell death in Drosophila Development; Vol. 120; No. 8;

Jongens, Thomas A.; Hay, Bruce et al. (1992) The germ cell-less gene product: A posteriorly localized component necessary for germ cell development in Drosophila Cell; Vol. 70; No. 4;

Hay, Bruce; Jan, Lily Yeh et al. (1990) Localization of vasa, a component of Drosophila polar granules, in maternal-effect mutants that alter embryonic anteroposterior polarity Development; Vol. 109; No. 2;

Hay, Bruce; Jan, Lily Yeh et al. (1988) A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases Cell; Vol. 55; No. 4;

Hay, Bruce A.; Ackerman, Larry et al. (1988) Identification of a component of Drosophila polar granules Development; Vol. 103; No. 4;

Hay, Bruce; Prusiner, Stanley B. et al. (1987) Evidence for a secretory form of the cellular prion protein Biochemistry; Vol. 26; No. 25;

McKinley, Michael P.; Hay, Bruce et al. (1987) Developmental expression of prion protein gene in brain Developmental Biology; Vol. 121; No. 1;

Hay, Bruce; Barry, Ronald A. et al. (1987) Biogenesis and transmembrane orientation of the cellular isoform of the scrapie prion protein Molecular and Cellular Biology; Vol. 7; No. 2;