[ { "id": "https://authors.library.caltech.edu/records/fts5t-h6h79", "eprint_id": 103327, "eprint_status": "archive", "datestamp": "2023-08-22 06:52:31", "lastmod": "2024-01-15 04:30:24", "type": "book_section", "metadata_visibility": "show", "creators": { "items": [ { "id": "Guo-Chin-Lin", "name": { "family": "Guo", "given": "Chin-Lin" } }, { "id": "Ouyang-Mingxing", "name": { "family": "Ouyang", "given": "Mingxing" } }, { "id": "Yu-Jiun-Yann", "name": { "family": "Yu", "given": "Jiun-Yann" } } ] }, "title": "Long-Range Mechanical Force Enables Self-Assembly of Epithelial Tubules", "ispublished": "unpub", "full_text_status": "restricted", "keywords": "Mechanical force; Long-range; Extracellular matrix; Spatial pattern", "note": "\u00a9 2013 The Society for Experimental Mechanics, Inc. \n\nFirst Online: 10 September 2012.", "abstract": "Spatiotemporal coordination of cell positioning and differentiation is critical in morphogenesis. Loss of coordination is often a hallmark of tissue abnormality and tumorigenesis. Recent studies indicate the importance of mechanical force in morphogenesis such as tubular pattern formation. However, how cells coordinate mechanical interactions between each other and with extracellular matrix (ECM), to initiate, regulate, or maintain long-range tubular patterns is unclear. Using a two-step process to quantitatively control cell-ECM interaction, we find that epithelial cells, in response to a fine-tuned percentage of type I collagen (COL) in ECM, develop various patterns resembling those observed in tubulo-lobular organs. In contrast with conventional thought, these patterns arise through mechanical interactions between cells, but not through gradients of diffusible biochemical factors. Remarkably, a very large spatial scale of tubular patterns is found by cell-COL self-organization in the liquid phase, leading to the formation of long-range (~1 cm) epithelial tubule. Our results suggest a potential mechanism cells can use to form and coordinate long-range tubular patterns, independent of those controlled by diffusible biochemical factors, and provide a new strategy to engineer/regenerate tubular organs.", "date": "2012-09-10", "date_type": "published", "publisher": "Springer", "place_of_pub": "New York, NY", "pagerange": "15-21", "id_number": "CaltechAUTHORS:20200519-144050973", "isbn": "978-1-4614-4426-8", "book_title": "Mechanics of Biological Systems and Materials", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20200519-144050973", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "contributors": { "items": [ { "id": "Prorok-B-C", "name": { "family": "Prorok", "given": "Barton C." } }, { "id": "Barthelat-F", "name": { "family": "Barthelat", "given": "Fran\u00e7ois" } }, { "id": "Korach-C-S", "name": { "family": "Korach", "given": "Chad S." } }, { "id": "Grande-Allen-K-J", "name": { "family": "Grande-Allen", "given": "K. Jane" } }, { "id": "Lipke-E", "name": { "family": "Lipke", "given": "Elizabeth" } }, { "id": "Lykofatitits-G", "name": { "family": "Lykofatitits", "given": "George" } }, { "id": "Zavattieri-P", "name": { "family": "Zavattieri", "given": "Pablo" } } ] }, "doi": "10.1007/978-1-4614-4427-5_3", "resource_type": "book_section", "pub_year": "2012", "author_list": "Guo, Chin-Lin; Ouyang, Mingxing; et el." }, { "id": "https://authors.library.caltech.edu/records/c6375-16n37", "eprint_id": 27659, "eprint_status": "archive", "datestamp": "2023-08-19 08:01:52", "lastmod": "2024-01-13 05:46:13", "type": "book_section", "metadata_visibility": "show", "creators": { "items": [ { "id": "Guo-Chin-Lin", "name": { "family": "Guo", "given": "Chin-Lin" } }, { "id": "Ouyang-Mingxing", "name": { "family": "Ouyang", "given": "Mingxing" } }, { "id": "Yu-Jiun-Yann", "name": { "family": "Yu", "given": "Jiun-Yann" } }, { "id": "Price-Andrew", "name": { "family": "Price", "given": "Andrew" } }, { "id": "Maslov-Jordan", "name": { "family": "Maslov", "given": "Jordan" } } ] }, "title": "Long-range mechanical force in colony branching and tumor invasion", "ispublished": "unpub", "full_text_status": "public", "keywords": "mechanical force, long-range, extracellular matrix, branching morphogenesis, tumor invasion, spatial pattern", "note": "\u00a9 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). \nOnline Sep 12, 2011.\n\n
Published - Guo_2011.pdf
", "abstract": "The most concerned factors for cancer prognosis are tumor invasion and metastasis. The patterns of tumor invasion can be characterized as random infiltration to surrounding extracellular matrix (ECM) or formation of long-range path for collective migration. Recent studies indicate that mechanical force plays an important role in tumor infiltration and collective migration. However, how tumor colonies develop mechanical interactions with each other to initiate various invasion patterns is unclear. Using a micro-patterning technique, we partition cells into clusters to mimic tumor colonies and quantitatively induce colony-ECM interactions. We find that pre-malignant epithelial cells, in response to concentrations of type I collagen in ECM ([COL]), develop various branching patterns resembling those observed in tumor invasion. In contrast with conventional thought, these patterns require long-range (~ 600 \u03bcm) transmission of traction force, but not biochemical factors. At low [COL], cell colonies synergistically develop pairwise and directed branching mimicking the formation of long-range path. By contrast, at high [COL] or high colony density, cell colonies develop random branching and scattering patterns independent of each other. Our results suggest that tumor colonies might select different invasive patterns depending on their interactions with each other and with the ECM.", "date": "2011-09-12", "date_type": "published", "publisher": "SPIE", "place_of_pub": "Bellingham, WA", "pagerange": "Art. No. 809903", "id_number": "CaltechAUTHORS:20111107-141527848", "isbn": "9780819487094", "book_title": "Biosensing and Nanomedicine IV", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20111107-141527848", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "contributors": { "items": [ { "id": "Mohseni-H", "name": { "family": "Mohseni", "given": "Hooman" } }, { "id": "Agahi-M-H", "name": { "family": "Agahi", "given": "Massoud H." } }, { "id": "Razeghi-M", "name": { "family": "Razeghi", "given": "Manijeh" } } ] }, "doi": "10.1117/12.911904", "primary_object": { "basename": "Guo_2011.pdf", "url": "https://authors.library.caltech.edu/records/c6375-16n37/files/Guo_2011.pdf" }, "resource_type": "book_section", "pub_year": "2011", "author_list": "Guo, Chin-Lin; Ouyang, Mingxing; et el." }, { "id": "https://authors.library.caltech.edu/records/9ja8v-e1d09", "eprint_id": 29921, "eprint_status": "archive", "datestamp": "2023-08-19 06:23:34", "lastmod": "2023-10-24 22:35:04", "type": "book_section", "metadata_visibility": "show", "creators": { "items": [ { "id": "Yu-Jiun-Yann", "name": { "family": "Yu", "given": "Jiun-Yann" } }, { "id": "Kuo-Chun-Hung", "name": { "family": "Kuo", "given": "Chun-Hung" } }, { "id": "Zadoyan-Ruben", "name": { "family": "Zadoyan", "given": "Ruben" } }, { "id": "Guo-Chin-Lin", "name": { "family": "Guo", "given": "Chin-Lin" } } ] }, "title": "Plane-projection multi-photon microscopy for high-frame-rate Live Tissue Imaging", "ispublished": "unpub", "full_text_status": "public", "note": "\u00a9 2011 Optical Society of America.\nDate of Current Version: 14 July 2011.\n\nPublished - ISI000295612403225Proceedings.pdf
", "abstract": "We present a wide-field multi-photon microscopy that provides optical sectioning at high frame rate under biocompatible laser dosage. Axial resolution comparable to confocal microscopy and 5-frame-per-second live tissue imaging are demonstrated.", "date": "2011-05", "date_type": "published", "publisher": "Optical Society of America", "place_of_pub": "Washington, DC", "pagerange": "PDPB4", "id_number": "CaltechAUTHORS:20120330-155304712", "isbn": "978-1-4577-1223-4", "book_title": "2011 Conference on Lasers and Electro-Optics (CLEO)", "official_url": "https://resolver.caltech.edu/CaltechAUTHORS:20120330-155304712", "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "other_numbering_system": { "items": [ { "id": "12135064", "name": "INSPEC Accession Number" } ] }, "primary_object": { "basename": "ISI000295612403225Proceedings.pdf", "url": "https://authors.library.caltech.edu/records/9ja8v-e1d09/files/ISI000295612403225Proceedings.pdf" }, "resource_type": "book_section", "pub_year": "2011", "author_list": "Yu, Jiun-Yann; Kuo, Chun-Hung; et el." } ]