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Robust control theory was developed in the late twentieth century as a mathematical framework to enable the principled incorporation of uncertainty into engineering design in applications like aerospace. However, engineered technologies that interface with living systems in applications like medicine and ecology must accommodate uncertainties and unmodeled dynamics far beyond what robust control theory has historically achieved. This thesis develops a robust control foundation for overcoming large-scale uncertainty and designing interfaces with living systems, through formal theory and three case studies: neural control of movement, immune control of viruses, and homeostatic control of neoplasia in the moon jellyfish.
\r\n \r\nThe central argument of this thesis is that these three systems, along with many others, have two key properties that enable new approaches to the uncertainty intrinsic to their study: they are themselves control systems, and they are multicellular systems. These properties motivate new work in control theory, blending recent results in localized and distributed control with older results from robust and modern control. The resulting theory framework answers domain-specific questions, guides the design of new experiments and technologies, and enables a conceptual synthesis. By leveraging the fact that these are multicellular control systems, we are able to make progress in theory, basic science, and engineering.
", "date": "2023", "date_type": "degree", "id_number": "CaltechTHESIS:07052022-033543855", "refereed": "FALSE", "official_url": "https://resolver.caltech.edu/CaltechTHESIS:07052022-033543855", "related_url": { "items": [ { "description": "Article adapted for Chapter 5.", "type": "doi", "url": "https://doi.org/10.23919/ACC.2019.8814926" } ] }, "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "collection": "CaltechTHESIS", "reviewer": "Melissa Ray", "suggestions": "Released 2023-01-11 after author agreed there wasn't a sufficient reason to approve an extension request.\r\n\r\n\r\n// Restricted to Caltech community only until 11 January 2023. Extension request has been withdrawn by student 20230110. // \r\n\r\n// From author: This thesis includes work (related to Chapter 3, Chapter 4, Chapter 6, and Chapter 7) that is intended to be submitted for publication within the next six months. Because many of the key contributions of this work are theoretical, I would like to take care to make sure that these papers are submitted before the restriction is lifted.", "deposited_by": "Anish Sarma", "deposited_on": "2022-07-11 23:13:34", "doi": "10.7907/kf54-fr89", "divisions": { "items": [ "div_bbe" ] }, "institution": "California Institute of Technology", "thesis_type": "phd", "thesis_advisor": { "items": [ { "email": "doyle@caltech.edu", "id": "Doyle-J-C", "name": { "family": "Doyle", "given": "John Comstock" }, "orcid": "0000-0002-1828-2486", "role": "co-advisor" }, { "email": "goentoro@caltech.edu", "id": "Goentoro-L-A", "name": { "family": "Goentoro", "given": "Lea A." }, "orcid": "0000-0002-3904-0195", "role": "co-advisor" } ] }, "thesis_committee": { "items": [ { "email": "goentoro@caltech.edu", "id": "Goentoro-L-A", "name": { "family": "Goentoro", "given": "Lea A." }, "orcid": "0000-0002-3904-0195", "role": "chair" }, { "email": "doyle@caltech.edu", "id": "Doyle-J-C", "name": { "family": "Doyle", "given": "John Comstock" }, "orcid": "0000-0002-1828-2486", "role": "member" }, { "email": "evroth@its.caltech.edu", "id": "Rothenberg-E-V", "name": { "family": "Rothenberg", "given": "Ellen V." }, "orcid": "0000-0002-3901-347X", "role": "member" }, { "email": "dmbrandman@ucdavis.edu", "id": "Brandman-D-M", "name": { "family": "Brandman", "given": "David M." }, "role": "member" } ] }, "thesis_degree": "PHD", "thesis_degree_grantor": "California Institute of Technology", "thesis_defense_date": "2022-06-17", "gradofc_approval_date": "2022-07-11", "review_status": "approved", "option_major": { "items": [ "cns" ] }, "option_minor": { "items": [ "cds" ] }, "copyright_statement": "Author's Rights Authorization: I hereby certify that, if appropriate, I have obtained a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted here is the same as that approved by my advisory committee.\n\nI hereby grant to California Institute of Technology or its agents the non-exclusive license to archive and make accessible, under the conditions specified under \"Thesis Availability\" in this submission, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation, or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.", "resource_type": "thesis", "pub_year": "2023", "author_list": "Sarma, Anish Anandsai", "advisor_list": "Doyle, John Comstock and Goentoro, Lea A.", "comittee_list": "Goentoro, Lea A.; Doyle, John Comstock; et el." }, { "id": "https://thesis.library.caltech.edu/id/eprint/11281", "eprint_id": 11281, "rev_number": 33, "documents": [ { "id": "/id/document/95246", "doc_id": 95246, "rev_number": 5, "files": [ { "id": "/id/file/271402", "fileid": 271402, "datasetid": "document", "objectid": 95246, "filename": "Noah_Olsman_Thesis_Final.pdf", "mime_type": "application/pdf", "hash": "371699601acbf355eff54c02c67150c2", "hash_type": "MD5", "filesize": 3608771, "mtime": "2018-11-26 19:52:54", "url": "/11281/1/Noah_Olsman_Thesis_Final.pdf" } ], "eprint_id": 11281, "pos": 1, "placement": 1, "mime_type": "application/pdf", "format": "application/pdf", "language": 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between the low-level structure and parameters of a biomolecular network and its high-level function and performance. Elucidating this mapping has become increasingly feasible as precise measurements of both input parameters and output dynamics become abundant. At the same time, cross-pollination between biology and engineering has led to the realization that many of the mathematical tools from control theory are well-suited to analyze biological processes.
\r\n\r\nThe goal of this thesis is to use tools from control theory to analyze a variety of biomolecular systems from both natural and synthetic settings, and subsequently yield insight into the architecture, tradeoffs, and limitations of biological network. In Chapter 2, I demonstrate how allosteric proteins can be used to respond logarithmically to changes in signal. In Chapter 3, I show how control theoretic techniques can be used to inform the design of synthetic integral feedback networks that implement feedback with a sequestration mechanism. Finally, in Chapter 4 I present a novel simplified model of the E. coli heat shock response system and show how the the mapping of circuit parameters to function depends on the network's architecture.
\r\n\r\nThe unifying theme of this research is that the conceptual framework used to study engineered systems is remarkably well-suited to biology. That being said, it is important to apply these tools in a way that is informed by the molecular details of biological processes. By combining structural and biochemical data with the functional perspective of engineering, it is possible to understand the architectural principles that underlie living systems.
", "date": "2019", "date_type": "degree", "id_number": "CaltechTHESIS:11262018-100422941", "refereed": "FALSE", "official_url": "https://resolver.caltech.edu/CaltechTHESIS:11262018-100422941", "related_url": { "items": [ { "description": "Published paper associated with Chapter 2.", "type": "doi", "url": "https://doi.org/10.1073/pnas.1601791113" }, { "description": "Preprint of paper associated with Chapter 3.", "type": "doi", "url": "https://doi.org/10.1101/222042 " }, { "description": "Preprint of paper associated with Chapter 3.", "type": "doi", "url": "https://doi.org/10.1101/428300 " } ] }, "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "James S. McDonnell Foundation", "grant_number": "220020365" }, { "agency": "Defense Advanced Research Projects Agency (DARPA)", "grant_number": "HR0011-17-2-0008" } ] }, "collection": "CaltechTHESIS", "reviewer": "Melissa Ray", "deposited_by": "Noah Olsman", "deposited_on": "2018-11-27 19:30:26", "doi": "10.7907/DGPY-1679", "divisions": { "items": [ "div_eng" ] }, "institution": "California Institute of Technology", "thesis_type": "phd", "thesis_advisor": { "items": [ { "email": "lgoentor@caltech.edu", "id": "Goentoro-L-A", "name": { "family": "Goentoro", "given": "Lea A." }, "role": "co-advisor" }, { "email": "doyle@caltech.edu", "id": "Doyle-J-C", "name": { "family": "Doyle", "given": "John C." }, "role": "co-advisor" } ] }, "thesis_committee": { "items": [ { "email": "murray@cds.caltech.edu", "id": "Murray-R-M", "name": { "family": "Murray", "given": "Richard M." }, "role": "chair" }, { "email": "bois@caltech.edu", "id": "Bois-Justin-S", "name": { "family": "Bois", "given": "Justin S." }, "role": "member" }, { "email": "doyle@caltech.edu", "id": "Doyle-J-C", "name": { "family": "Doyle", "given": "John C." }, "role": "member" }, { "email": "lgoentor@caltech.edu", "id": "Goentoro-L-A", "name": { "family": "Goentoro", "given": "Lea A." }, "role": "member" } ] }, "thesis_degree": "PHD", "thesis_degree_grantor": "California Institute of Technology", "thesis_defense_date": "2018-11-16", "gradofc_approval_date": "2018-11-27", "review_status": "approved", "option_major": { "items": [ "cds" ] }, "copyright_statement": "Author's Rights Authorization: I hereby certify that, if appropriate, I have obtained a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted here is the same as that approved by my advisory committee.\n\nI hereby grant to California Institute of Technology or its agents the non-exclusive license to archive and make accessible, under the conditions specified under \"Thesis Availability\" in this submission, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation, or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.", "resource_type": "thesis", "pub_year": "2019", "author_list": "Olsman, Noah Andrew", "advisor_list": "Goentoro, Lea A. and Doyle, John C.", "comittee_list": "Murray, Richard M.; Bois, Justin S.; et el." }, { "id": "https://thesis.library.caltech.edu/id/eprint/11353", "eprint_id": 11353, "rev_number": 36, "documents": [ { "id": "/id/document/96337", "doc_id": 96337, "rev_number": 4, "files": [ { "id": "/id/file/275635", "fileid": 275635, "datasetid": "document", "objectid": 96337, "filename": "Thesis_Nunns2019_final.pdf", "mime_type": "application/pdf", "hash": "1d89402f04a590c18dd5525d12313581", "hash_type": "MD5", "filesize": 4185314, "mtime": "2019-01-23 03:14:57", "url": "/11353/7/Thesis_Nunns2019_final.pdf" } ], "eprint_id": 11353, "pos": 7, "placement": 7, "mime_type": "application/pdf", "format": "application/pdf", "language": "en", "security": 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Communication between cells is carried out by a highly conserved set of signaling pathways, whose dysregulation can lead to many diseases. The molecular details of these signaling pathways are now well-characterized, allowing researchers to investigate the emergent properties that arise from the complex signaling networks. These properties often arise from counter-intuitive or paradoxical mechanisms, meaning that systems-level analysis is necessary. Importantly, mathematical models have been constructed for many pathways that capture measured reaction rates and protein levels. These mathematical models successfully recapitulate dynamic responses of each pathway. Here, I investigated the input-output response of the Wnt, MAPK/ERK, and Tgf\u03b2 pathways using analytical and numerical treatment of mathematical models. Using this approach, I found that the distinct architectures of the three signaling pathways lead to a convergent behavior, linear input-output response. Specifically, mathematical analysis reveals that a futile cycle in the Wnt pathway, a kinase cascade coupled to feedback in the ERK pathway, and nucleocytoplasmic shuttling in the Tgf\u03b2 pathways all yield linear signal transmission. I then verified this finding experimentally in the Wnt and ERK pathways. For the Wnt pathway, direct measurements of the input-output response reveal that \u03b2-catenin is linear with respect to Wnt co-receptor LRP5/6 activity up until receptor saturation. For the ERK pathway, direct measurements indicate a linear relationship between phosphorylated ERK1/2 and the concentration of EGF ligand, up until saturation of ERK1/2. Finally, mathematical modeling reveals that linear response in the Wnt pathway, in conjunction with a recently identified cis-regulatory motif, is sufficient to explain gene expression buffering to perturbations. Therefore, this thesis demonstrates how linearity emerges across three dissimilar architectures, and introduces a novel benefit for linear signal transmission in biology.
", "date": "2019", "date_type": "degree", "id_number": "CaltechTHESIS:01222019-133152032", "refereed": "FALSE", "official_url": "https://resolver.caltech.edu/CaltechTHESIS:01222019-133152032", "related_url": { "items": [ { "description": "Article adapted for Chapters 2 and 3.", "type": "doi", "url": "https://doi.org/10.7554/eLife.33617.001" }, { "description": "Article adapted for Chapter 4.", "type": "doi", "url": "https://doi.org/10.1016/j.molcel.2009.11.018" } ] }, "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NIH", "grant_number": "5T32GM007616-37" } ] }, "collection": "CaltechTHESIS", "reviewer": "Melissa Ray", "deposited_by": "Harry Nunns", "deposited_on": "2019-02-04 22:07:51", "doi": "10.7907/WP0J-E945", "divisions": { "items": [ "div_bbe" ] }, "institution": "California Institute of Technology", "thesis_type": "phd", "thesis_advisor": { "items": [ { "email": "goentoro@caltech.edu", "id": "Goentoro-L-A", "name": { "family": "Goentoro", "given": "Lea A." }, "role": "advisor" } ] }, "thesis_committee": { "items": [ { "email": "pws@caltech.edu", "id": "Sternberg-P-W", "name": { "family": "Sternberg", "given": "Paul W." }, "role": "chair" }, { "email": "melowitz@caltech.edu", "id": "Elowitz-M-B", "name": { "family": "Elowitz", "given": "Michael B." }, "role": "member" }, { "email": "murray@caltech.edu", "id": "Murray-R-M", "name": { "family": "Murray", "given": "Richard M." }, "role": "member" }, { "email": "goentoro@caltech.edu", "id": "Goentoro-L-A", "name": { "family": "Goentoro", "given": "Lea A." }, "role": "member" } ] }, "thesis_degree": "PHD", "thesis_degree_grantor": "California Institute of Technology", "thesis_defense_date": "2019-01-11", "gradofc_approval_date": "2019-02-04", "review_status": "approved", "option_major": { "items": [ "sysbiol" ] }, "copyright_statement": "Author's Rights Authorization: I hereby certify that, if appropriate, I have obtained a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted here is the same as that approved by my advisory committee.\n\nI hereby grant to California Institute of Technology or its agents the non-exclusive license to archive and make accessible, under the conditions specified under \"Thesis Availability\" in this submission, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation, or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.", "resource_type": "thesis", "pub_year": "2019", "author_list": "Nunns, Harry James Rogan", "advisor_list": "Goentoro, Lea A.", "comittee_list": "Sternberg, Paul W.; Elowitz, Michael B.; et el." }, { "id": "https://thesis.library.caltech.edu/id/eprint/11730", "eprint_id": 11730, "rev_number": 35, "documents": [ { "id": "/id/document/101921", "doc_id": 101921, "rev_number": 4, "files": [ { "id": "/id/file/292841", "fileid": 292841, "datasetid": "document", "objectid": 101921, "filename": "Caltech_Thesis_final.pdf", "mime_type": "application/pdf", "hash": "e753f878b45865e92f2ff56da893464a", "hash_type": "MD5", "filesize": 12245969, "mtime": "2019-06-11 00:31:45", "url": "/11730/7/Caltech_Thesis_final.pdf" } ], "eprint_id": 11730, "pos": 7, "placement": 7, "mime_type": "application/pdf", "format": "application/pdf", "language": "en", "security": "public", 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for development, growth, and maintenance of a community of cells in a multicellular organism. Signaling pathways are highly conserved systems of communication between cells, each composed of a distinct network of protein interactions that detect extracellular signal and transduce the signal information for cellular response. A signaling pathway typically encodes information from signaling events into dynamics of second messengers, intracellular molecules in the signaling pathway that activate in response to signal and initiate cellular response. Therefore, understanding how information is encoded in second messenger dynamics, and how transcriptional machinery decode and generate output response is an important aspect in investigating how signaling information is transduced inside a cell. In the first chapter, we investigate the timescales of memory in endogenous \u03b2-catenin and Smad3, second messengers in the Wnt and Tgf-\u03b2 pathways, through single cell timelapse microscopy. The findings demonstrate that both second messengers have short memory and high cell-to-cell variability, and that their memory is tunable through modulating cellular contexts. In the second chapter, we investigate decoding of information from \u03b2-catenin in the Wnt pathway. We identify a novel 11-bp DNA element that recruit \u03b2-catenin for transcriptional suppression. This negative regulatory element is shown to act in conjunction with the canonical Wnt responsive element to form an incoherent feedforward loop (IFFL). Through mathematical simulations, we present how the IFFL circuit can generate complex output functions in decoding \u03b2-catenin dynamics, which include those that confer robustness against perturbations in signaling response such as band-pass filtering and fold change detection.
\r\n", "date": "2019", "date_type": "degree", "id_number": "CaltechTHESIS:06092019-220453694", "refereed": "FALSE", "official_url": "https://resolver.caltech.edu/CaltechTHESIS:06092019-220453694", "related_url": { "items": [ { "description": "Article adapted for Ch. 3.", "type": "doi", "url": "https://doi.org/10.1016/j.cub.2017.06.037" } ] }, "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "collection": "CaltechTHESIS", "reviewer": "Kathy Johnson", "deposited_by": "Kibeom Kim", "deposited_on": "2019-06-11 18:38:38", "doi": "10.7907/BJDQ-JX45", "divisions": { "items": [ "div_bbe" ] }, "institution": "California Institute of Technology", "thesis_type": "phd", "thesis_advisor": { "items": [ { "email": "lgoentor@caltech.edu", "id": "Goentoro-L-A", "name": { "family": "Goentoro", "given": "Lea A." }, "role": "advisor" } ] }, "thesis_committee": { "items": [ { "email": "melowitz@caltech.edu", "id": "Elowitz-M-B", "name": { "family": "Elowitz", "given": "Michael B." }, "role": "chair" }, { "email": "haybruce@caltech.edu", "id": "Hay-B-A", "name": { "family": "Hay", "given": "Bruce A." }, "role": "member" }, { "email": "lgoentor@caltech.edu", "id": "Goentoro-L-A", "name": { "family": "Goentoro", "given": "Lea A." }, "role": "member" }, { "email": "zinnk@caltech.edu", "id": "Zinn-K-G", "name": { "family": "Zinn", "given": "Kai George" }, "role": "member" } ] }, "thesis_degree": "PHD", "thesis_degree_grantor": "California Institute of Technology", "thesis_defense_date": "2019-05-23", "gradofc_approval_date": "2019-06-11", "review_status": "approved", "option_major": { "items": [ "sysbiol" ] }, "copyright_statement": "Author's Rights Authorization: I hereby certify that, if appropriate, I have obtained a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted here is the same as that approved by my advisory committee.\n\nI hereby grant to California Institute of Technology or its agents the non-exclusive license to archive and make accessible, under the conditions specified under \"Thesis Availability\" in this submission, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation, or project report. 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"pos": 16, "placement": 16, "mime_type": "text/plain", "format": "other", "format_desc": "Generate index codes conversion from application/pdf to indexcodes", "language": "en", "security": "public", "license": "other", "main": "indexcodes.txt", "media_duration": "0", "media_aspect_ratio": "0", "media_sample_start": "0", "media_sample_stop": "0", "relation": { "items": [ { "type": "http://eprints.org/relation/isVersionOf", "uri": "/id/document/99078" }, { "type": "http://eprints.org/relation/isVolatileVersionOf", "uri": "/id/document/99078" }, { "type": "http://eprints.org/relation/isIndexCodesVersionOf", "uri": "/id/document/99078" } ] } } ], "eprint_status": "archive", "userid": 11959, "dir": "disk0/00/01/15/32", "datestamp": "2019-05-23 20:06:51", "lastmod": "2019-10-04 00:25:45", "status_changed": "2019-05-23 20:06:51", "type": "thesis", "metadata_visibility": "show", "creators": { "items": [ { "email": "cfrick13@gmail.com", "id": "Frick-Christopher-Lee", "name": { "family": "Frick", "given": "Christopher Lee" }, "orcid": "0000-0001-6823-5920" } ] }, "title": "How Single Cells Sense Smad3 Signal", "ispublished": "unpub", "full_text_status": "public", "keywords": "Systems Biology, Cell Signaling, Signal Transduction, Manifold Learning, Hidden Variables", "abstract": "Animal cells possess the remarkable ability to send, receive, and respond to molecular signals. Accurate processing of these signals is essential for the development and maintenance of complex cell fates and organization. The regulation of cell behavior in response to signal is mediated by signal transduction pathways, which are highly conserved protein-protein interaction networks. Recent work has shown that the activation of biomolecular networks is highly sensitive to natural cellular variation in protein levels, making it unclear how these pathways accurately and reliably transmit signals in single cells. In this thesis, I address this question in the Transforming Growth Factor-\u03b2 (Tgf-\u03b2) pathway, a major intercellular signaling pathway in animal cells. First, we asked whether extracellular signal is accurately transduced into pathway activation in single cells. Examining pathway dynamics in live reporter cells, we found evidence for fold-change detection. Although the level of nuclear Smad3 varied across cells, the fold change in the level of nuclear Smad3 was a more precise outcome of ligand stimulation. Indeed, by measuring Smad3 dynamics and gene expression in the same cells, we confirm that the fold-change in Smad3 carries signal in the pathway. These findings suggest that cells encode Tgf-\u03b2 signal in a precise Smad3 fold-change as a strategy for coping with cellular noise. Second, we brought two significant advancements, which enabled us to ask how tightly signaling dynamics dictates target gene expression. By imaging endogenous dynamics of both signaling and gene expression in clonal cells, and correlating the full dynamics with a non-manifold learning approach, we show that knowing the full dynamics of Smad3 is necessary but not sufficient to predict the full dynamics of target gene expression. Indeed, we find evidence for the role of mTOR, MEK5, and cell cycle as cell-specific variables that influence how a cell responds to Smad3. This demonstrates the extent to which, even across clonal cells, response to signal considerably varies, as each cell computes decisions based on its own internal state.", "date": "2019", "date_type": "degree", "id_number": "CaltechTHESIS:05222019-160829503", "refereed": "FALSE", "official_url": "https://resolver.caltech.edu/CaltechTHESIS:05222019-160829503", "related_url": { "items": [ { "description": "Article adapted for Ch. 2", "type": "doi", "url": "https://doi.org/10.1073/pnas.1611428114" } ] }, "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NIH", "grant_number": "2T32GM007616-36 " } ] }, "collection": "CaltechTHESIS", "reviewer": "Kathy Johnson", "deposited_by": "Christopher Frick", "deposited_on": "2019-05-23 20:06:51", "doi": "10.7907/WNM4-4R58", "divisions": { "items": [ "div_bbe" ] }, "institution": "California Institute of Technology", "thesis_type": "phd", "thesis_advisor": { "items": [ { "email": "goentoro@caltech.edu", "id": "Goentoro-L-A", "name": { "family": "Goentoro", "given": "Lea A." }, "role": "advisor" } ] }, "thesis_committee": { "items": [ { "email": "melowitz@caltech.edu", "id": "Elowitz-M-B", "name": { "family": "Elowitz", "given": "Michael B." }, "role": "chair" }, { "email": "haybruce@caltech.edu", "id": "Hay-B-A", "name": { "family": "Hay", "given": "Bruce A." }, "role": "member" }, { "email": "phillips@pboc.caltech.edu", "id": "Phillips-R-B", "name": { "family": "Phillips", "given": "Robert B." }, "role": "member" }, { "email": "goentoro@caltech.edu", "id": "Goentoro-L-A", "name": { "family": "Goentoro", "given": "Lea A." }, "role": "member" } ] }, "thesis_degree": "PHD", "thesis_degree_grantor": "California Institute of Technology", "thesis_defense_date": "2019-05-03", "gradofc_approval_date": "2019-05-23", "review_status": "approved", "option_major": { "items": [ "biochem" ] }, "copyright_statement": "Author's Rights Authorization: I hereby certify that, if appropriate, I have obtained a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted here is the same as that approved by my advisory committee.\n\nI hereby grant to California Institute of Technology or its agents the non-exclusive license to archive and make accessible, under the conditions specified under \"Thesis Availability\" in this submission, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation, or project report. 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Working in Aurelia we have discovered a novel strategy of self-repair; we determined that they can undergo body reorganization after amputations that culminates in the recovery of essential radial symmetry without rebuilding lost parts. Working with Cassiopea, we have, for the first time, identified a behavioral sleep-like state in an animal without a centralized nervous system, supporting the hypothesis that sleep is ancestral in animals.
", "date": "2018", "date_type": "degree", "id_number": "CaltechTHESIS:06042018-104549400", "refereed": "FALSE", "official_url": "https://resolver.caltech.edu/CaltechTHESIS:06042018-104549400", "projects": { "items": [ "Self-repair in Aurelia Aurita", "Sleep in Cassiopea" ] }, "rights": "No commercial reproduction, distribution, display or performance rights in this work are provided.", "funders": { "items": [ { "agency": "NSF Graduate Research Fellowship", "grant_number": "1144469" } ] }, "collection": "CaltechTHESIS", "reviewer": "Melissa Ray", "deposited_by": "Michael Abrams", "deposited_on": "2018-06-06 20:07:57", "doi": "10.7907/69br-kb59", "divisions": { "items": [ "div_bbe" ] }, "institution": "California Institute of Technology", "thesis_type": "phd", "thesis_advisor": { "items": [ { "email": "goentoro@caltech.edu", "id": "Goentoro-L-A", "name": { "family": "Goentoro", "given": "Lea A." }, "role": "advisor" } ] }, "thesis_committee": { "items": [ { "email": "haybruce@caltech.edu", "id": "Hay-B-A", "name": { "family": "Hay", "given": "Bruce A." }, "role": "chair" }, { "email": "jodabiri@stanford.edu", "id": "Dabiri-J-O", "name": { "family": "Dabiri", "given": "John O." }, "role": "member" }, { "email": "pws@caltech.edu", "id": "Sternberg-P-W", "name": { "family": "Sternberg", "given": "Paul W." }, "role": "member" }, { "email": "goentoro@caltech.edu", "id": "Goentoro-L-A", "name": { "family": "Goentoro", "given": "Lea A." }, "role": "member" } ] }, "thesis_degree": "PHD", "thesis_degree_grantor": "California Institute of Technology", "thesis_defense_date": "2018-05-17", "gradofc_approval_date": "2018-06-06", "thesis_awards": "Miller Fellowship for Research at Berkeley ", "review_status": "approved", "option_major": { "items": [ "biology" ] }, "copyright_statement": "Author's Rights Authorization: I hereby certify that, if appropriate, I have obtained a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted here is the same as that approved by my advisory committee.\n\nI hereby grant to California Institute of Technology or its agents the non-exclusive license to archive and make accessible, under the conditions specified under \"Thesis Availability\" in this submission, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation, or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.", "resource_type": "thesis", "pub_year": "2018", "author_list": "Abrams, Michael Jacob", "advisor_list": "Goentoro, Lea A.", "comittee_list": "Hay, Bruce A.; Dabiri, John O.; et el." } ]