[ { "id": "authors:4yexd-djv11", "collection": "authors", "collection_id": "4yexd-djv11", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20211215-175040197", "type": "conference_item", "title": "Skin-interfaced wearable sweat biosensors", "author": [ { "family_name": "Gao", "given_name": "Wei", "orcid": "0000-0002-8503-4562", "clpid": "Gao-Wei" } ], "abstract": "Wearable devices can play an important role in personalized healthcare as they allow continuous data collection during\nan individual's daily activities toward predictive analytics and treatment. In this talk, I will introduce our efforts in\ndeveloping fully-integrated skin-interfaced biosensors for non-invasive mol. anal. Such wearable biosensors can\ncontinuously, selectively, and accurately measure a broad spectrum of sweat analytes including metabolites, electrolytes, hormones, drugs, and other small mols. The clin. value of our wearable sensing platforms is evaluated through multiple human studies involving both healthy and patient populations toward physiol. monitoring, nutritional monitoring, disease diagnosis, mental health assessment, and drug personalization. This talk will feature our recent works on self-powered battery-free electronic skins and mHealth-based biosensors for multiplexed COVID-19 diagnosis and management. These wearable and flexible devices could open the door to a wide range of personalized monitoring, diagnostic, and therapeutic applications.", "publisher": "Caltech Library", "publication_date": "2021-08" }, { "id": "authors:e71sq-vth49", "collection": "authors", "collection_id": "e71sq-vth49", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20211215-171713612", "type": "conference_item", "title": "Flexible and wireless graphene-based electrochemical mHealth system towards wearable stress monitoring", "author": [ { "family_name": "Tu", "given_name": "Jiaobing", "orcid": "0000-0002-7653-6640", "clpid": "Tu-Jiaobing" }, { "family_name": "Torrente-Rodr\u00edguez", "given_name": "Rebeca M.", "clpid": "Torrente-Rodr\u00edguez-Rebeca-M" }, { "family_name": "Yang", "given_name": "Yiran", "orcid": "0000-0001-8770-8746", "clpid": "Yang-Yiran" }, { "family_name": "Min", "given_name": "Jihong", "orcid": "0000-0002-5788-1473", "clpid": "Min-Jihong" }, { "family_name": "Wang", "given_name": "Minqiang", "orcid": "0000-0002-7775-8341", "clpid": "Wang-Minqiang" }, { "family_name": "Song", "given_name": "Yu", "orcid": "0000-0002-4185-2256", "clpid": "Song-Yu" }, { "family_name": "Yu", "given_name": "You", "orcid": "0000-0001-7059-7023", "clpid": "Yu-You" }, { "family_name": "Xu", "given_name": "Changhao", "clpid": "Xu-Changhao" }, { "family_name": "Ye", "given_name": "Cui", "orcid": "0000-0001-7689-6825", "clpid": "Ye-Cui" }, { "family_name": "IsHak", "given_name": "Waguih", "orcid": "0000-0003-1970-4756", "clpid": "IsHak-Waguih-W" }, { "family_name": "Gao", "given_name": "Wei", "orcid": "0000-0002-8503-4562", "clpid": "Gao-Wei" } ], "abstract": "Prompt and accurate assessment of stress is crucial to human performance anal. and mental health monitoring. To avoid stress-inducing blood sampling and to realize continuous, non-invasive, and real-time stress anal. at the mol. levels, we developed an integrated wireless electrochem. sensing device based on laser-engraved graphene that are mass producible at low cost. Cortisol detection is enabled by a flexible sensor array that can conformably laminate on skin and exploits the exceptional performance and 3D porous network of laser-engraved graphene for sensitive and selective immunosensing. We report a strong correlation between sweat and circulating cortisol and demonstrate the prompt detn. of sweat cortisol variation in response to acute stress stimuli. Moreover, we demonstrate, for the first time, the diurnal cycle and stress-response profile of sweat cortisol, revealing the potential of dynamic stress monitoring enabled by this mHealth sensing system.", "publisher": "Caltech Library", "publication_date": "2021-08" }, { "id": "authors:6f95p-89c95", "collection": "authors", "collection_id": "6f95p-89c95", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20201215-073715993", "type": "conference_item", "title": "Highly sensitive laser-engraved graphene sensors for non-invasive monitoring of circulating metabolites and\n nutrients", "author": [ { "family_name": "Yang", "given_name": "Yiran", "orcid": "0000-0001-8770-8746", "clpid": "Yang-Yiran" }, { "family_name": "Song", "given_name": "Yu", "orcid": "0000-0002-4185-2256", "clpid": "Song-Yu" }, { "family_name": "Bo", "given_name": "Xiangjie", "clpid": "Bo-Xiangjie" }, { "family_name": "Min", "given_name": "Jihong", "orcid": "0000-0002-5788-1473", "clpid": "Min-Jihong" }, { "family_name": "Gao", "given_name": "Wei", "orcid": "0000-0002-8503-4562", "clpid": "Gao-Wei" } ], "abstract": "Wearable sensors offer tremendous potential for biomedical applications. Sweat anal. is an attractive candidate that\nenables continuous and non-invasive mol. monitoring of circulating metabolites and nutrients. However, existing\nwearable sweat sensing platforms are primarily focused on a limited no. of electrolytes and metabolites monitored via ion selective or enzymic electrodes. Moreover, they either lack multimodal sensing functionality or require expensive\nmicro/nanofabrication facilities. Here we report a mass-producible, all-laser-engraved graphene sensor that enables\nhighly sensitive sweat anal. via differential pulse voltammetry and multiplexed vital sign monitoring. For the first time, we demonstrate here in situ continuous uric acid and tyrosine monitoring in human perspiration during exercise in both phys. trained and untrained subjects. The use of this platform for non-invasive gout management is evaluated on clin. diagnosed gout patients and via a purine-rich meal challenge on healthy individuals. This flexible graphene sensor demonstrates great promise for non-invasive, personalized metabolic and nutritional management.", "publisher": "Caltech Library", "publication_date": "2020-08" }, { "id": "authors:abydq-thp49", "collection": "authors", "collection_id": "abydq-thp49", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20190812-135344837", "type": "conference_item", "title": "Flexible lab on the skin for personalized molecular monitoring", "author": [ { "family_name": "Gao", "given_name": "Wei", "orcid": "0000-0002-8503-4562", "clpid": "Gao-Wei" } ], "abstract": "Wearable sensors play a crucial role in realizing personalized medicine, as they can continuously collect data from the human body to capture meaningful health status changes in time for preventive intervention. In this talk, I will introduce a flexible biosensing system for in-situ perspiration anal., which can selectively and accurately measure a wide spectrum of sweat analytes (e.g., metabolites, electrolytes, heavy metals, substances, and hormones). This platform allows us to gain real-time insight into the sweat secretion and gland physiol. To demonstrate the clin. value of our wearable sweat sensing platform, human subject studies were performed toward fitness monitoring, metabolic disorder monitoring, disease diagnosis, and drug monitoring. Such lab-on-skin platform opens the door to a wide range of personalized monitoring and diagnostic applications.", "publisher": "Caltech Library", "publication_date": "2019-08" }, { "id": "authors:daw8b-g2d48", "collection": "authors", "collection_id": "daw8b-g2d48", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180413-084509859", "type": "conference_item", "title": "Integrated wearable sensors for in situ sweat analysis", "author": [ { "family_name": "Gao", "given_name": "Wei", "orcid": "0000-0002-8503-4562", "clpid": "Gao-Wei" } ], "abstract": "The rising clin. and basic research interest in personalized and precision medicine promises to revolutionize traditional medical practices. This presents a tremendous opportunity for developing wearable devices toward predictive analytics and treatment. In this talk, I will introduce fully-integrated biosensors for multiplexed in-situ perspiration anal., which can selectively measure a wide spectrum of sweat analytes (e.g. metabolites, electrolytes, heavy metals and other small mols.) and allow us to gain real-time insight into the sweat-secretion and gland physiol. I will also demonstrate an intergrated wearable sweat extn. and sensing system which can be programmed to induce sweat on demand with various secretion profiles. To demonstrate the clin. value of our platform, human subject studies were performed in the context of the cystic fibrosis diagnosis. These wearable devices open the door to a wide range of personalized diagnostic and therapeutic applications.", "publisher": "Caltech Library", "publication_date": "2018-03" } ]