Elowitz, Michael B.

• Ma, Yitong; Budde, Mark W.; et el. (2023) Tuning Methylation-Dependent Silencing Dynamics by Synthetic Modulation of CpG Density; ACS Synthetic Biology; Vol. 12; No. 9; 2536-2545; 10.1021/acssynbio.3c00078
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• Kong, Qing; Xia, Shiyu; et el. (2023) Alternative splicing of GSDMB modulates killer lymphocyte-triggered pyroptosis; Science Immunology; Vol. 8; No. 82; Art. No. eadg3196; PMCID PMC10338320; 10.1126/sciimmunol.adg3196
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• Chen, Zibo; Linton, James M.; et el. (2022) A synthetic protein-level neural network in mammalian cells; 10.1101/2022.07.10.499405
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• Klumpe, Heidi E.; Langley, Matthew A.; et el. (2022) The context-dependent, combinatorial logic of BMP signaling; Cell Systems; Vol. 13; No. 5; 388-407; PMCID PMC9127470; 10.1016/j.cels.2022.03.002
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• Vlahos, Alexander E.; Kang, Jeewoo; et el. (2022) Protease-controlled secretion and display of intercellular signals; Nature Communications; Vol. 13; Art. No. 912; PMCID PMC8854555; 10.1038/s41467-022-28623-y
• Zhu, Ronghui; del Rio-Salgado, Jesus M.; et el. (2022) Synthetic multistability in mammalian cells; Science; Vol. 375; No. 6578; Art. No. eabg9765; 10.1126/science.abg9765
• Cable, Jennifer; Elowitz, Michael B.; et el. (2021) Single cell biology—a Keystone Symposia report; Annals of the New York Academy of Sciences; Vol. 1506; 74-97; 10.1111/nyas.14692
• Xu, Shuhui; Li, Kai; et el. (2021) Ratiometric RNA labeling allows dynamic multiplexed analysis of gene circuits in single cells; 10.1101/2021.09.23.461487
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• Chen, Zibo and Elowitz, Michael B. (2021) Programmable protein circuit design; Cell; Vol. 184; No. 9; 2284-2301; PMCID PMC8087657; 10.1016/j.cell.2021.03.007
• Chow, Ke-Huan K.; Budde, Mark W.; et el. (2021) Imaging cell lineage with a synthetic digital recording system; Science; Vol. 372; No. 6538; Art. No. eabb3099; 10.1126/science.abb3099
• Flynn, Michael J.; Snitser, Olga; et el. (2020) A simple direct RT-LAMP SARS-CoV-2 saliva diagnostic; 10.1101/2020.11.19.20234948
• Ding, Fangyuan and Elowitz, Michael B. (2020) Quantitative single-cell splicing analysis reveals an ‘economy of scale’ filter for gene expression; 10.1101/457432
• Gao, Xiaojing J.; Chong, Lucy S.; et el. (2020) Engineering multiple levels of specificity in an RNA viral vector
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• Li, Pulin and Elowitz, Michael B. (2019) Communication codes in developmental signaling pathways; Development; Vol. 146; No. 12; Art. No. dev170977; PMCID PMC6602343; 10.1242/dev.170977
• Ding, Fangyuan and Elowitz, Michael B. (2019) Constitutive splicing and economies of scale in gene expression; Nature Structural & Molecular Biology; Vol. 26; No. 6; 424-432; PMCID PMC6663491; 10.1038/s41594-019-0226-x
• Nandagopal, Nagarajan; Santat, Leah A.; et el. (2019) Cis-activation in the Notch signaling pathway; eLife; Vol. 8; Art. No. e37880; PMCID PMC6345567; 10.7554/eLife.37880
• Ng, Kenneth K. N.; Yui, Mary A.; et el. (2018) A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment; eLife; Vol. 7; Art. No. e37851; PMCID PMC6245732; 10.7554/eLife.37851
• Martinez-Corral, Rosa; Raimundez, Elba; et el. (2018) Self-Amplifying Pulsatile Protein Dynamics without Positive Feedback; Cell Systems; Vol. 7; No. 4; 453-462; 10.1016/j.cels.2018.08.012
• Siddique, Hifzur; Zheng, Mengmei; et el. (2018) Novel NOTCH-Binding Protein Directs Self-Renewal of Tumor-Initiating Stem-like Cells and HCC Development through Cell Fate Reprogramming; Hepatology; Vol. 68; No. S1; Art. No. 1365; 10.1002/hep.30257
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• Rosenthal, Adam Z.; Qi, Yutao; et el. (2018) Metabolic interactions between dynamic bacterial subpopulations; eLife; Vol. 7; Art. No. e33099; PMCID PMC6025961; 10.7554/eLife.33099
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• Tycko, Josh; Van, Mike V.; et el. (2017) Advancing towards a global mammalian gene regulation model through single-cell analysis and synthetic biology; Current Opinion in Biomedical Engineering; Vol. 4; 174-193; 10.1016/j.cobme.2017.10.011
• Antebi, Yaron E.; Linton, James M.; et el. (2017) Combinatorial Signal Perception in the BMP Pathway; Cell; Vol. 170; No. 6; 1184-1196; PMCID PMC5612783; 10.1016/j.cell.2017.08.015
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• Clevers, Hans; Rafelski, Susanne; et el. (2017) What Is Your Conceptual Definition of “Cell Type” in the Context of a Mature Organism?; Cell Systems; Vol. 4; No. 3; 255-259; 10.1016/j.cels.2017.03.006
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• Hormoz, Sahand; Singer, Zakary S.; et el. (2016) Inferring Cell-State Transition Dynamics from Lineage Trees and Endpoint Single-Cell Measurements; Cell Systems; Vol. 3; No. 5; 419-433; PMCID PMC5142829; 10.1016/j.cels.2016.10.015
• Gao, Xiaojing J. and Elowitz, Michael B. (2016) Synthetic biology: Precision timing in a cell; Nature; Vol. 538; No. 7626; 462-463; 10.1038/nature19478
• Kueh, Hao Yuan; Yui, Mary A.; et el. (2016) Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment; Nature Immunology; Vol. 17; No. 8; 956-965; PMCID PMC4955789; 10.1038/ni.3514
• Rothenberg, E.; Kueh, H. Y.; et el. (2016) Dissecting the transcriptional regulatory network for early T-cell commitment; European Journal of Immunology; Vol. 46; No. S1; 797; 10.1002/eji.201670200
• Lin, Yihan and Elowitz, Michael B. (2016) Central Dogma Goes Digital; Molecular Cell; Vol. 61; No. 6; 791-792; 10.1016/j.molcel.2016.03.005
• Bintu, Lacramioara; Yong, John; et el. (2016) Dynamics of epigenetic regulation at the single-cell level; Science; Vol. 351; No. 6274; 720-724; PMCID PMC5108652; 10.1126/science.aab2956
• Lin, Yihan; Sohn, Chang Ho; et el. (2015) Combinatorial gene regulation by modulation of relative pulse timing; Nature; Vol. 527; No. 7576; 54-58; PMCID PMC4870307; 10.1038/nature15710
• Kim, Daniel H.; Marinov, Georgi K.; et el. (2015) Single-Cell Transcriptome Analysis Reveals Dynamic Changes in lncRNA Expression during Reprogramming; Cell Stem Cell; Vol. 16; No. 1; 88-101; PMCID PMC4291542; 10.1016/j.stem.2014.11.005
• Markson, Joseph S. and Elowitz, Michael B. (2014) Synthetic Biology of Multicellular Systems: New Platforms and Applications for Animal Cells and Organisms; ACS Synthetic Biology; Vol. 3; No. 12; 875-876; PMCID PMC4476972; 10.1021/sb500358y
• Sanghez, Valentina; Kee, Dustin; et el. (2014) HoxA3 Controls Notch Pathway to Repress Blood Development; Blood; Vol. 124; No. 21
• Levine, Joe H. and Elowitz, Michael B. (2014) Polyphasic feedback enables tunable cellular timers; Current Biology; Vol. 24; No. 20; R994-R995; PMCID PMC4451454; 10.1016/j.cub.2014.08.030
• LeBon, Lauren; Lee, Tom V.; et el. (2014) Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states; eLife; Vol. 3; Art. No. e02950; PMCID PMC4174579; 10.7554/eLife.02950
• Dalal, Chiraj K.; Cai, Long; et el. (2014) Pulsatile Dynamics in the Yeast Proteome; Current Biology; Vol. 24; No. 18; 2189-2194; PMCID PMC4203654; 10.1016/j.cub.2014.07.076
• Kueh, Hao Yuan; Elowitz, Michael B.; et el. (2014) Macrophage and T-cell fate control: Insights from tracking transcription factor dynamics in single cells; Experimental Hematology; Vol. 42; No. 8; S16; 10.1016/j.exphem.2014.07.054
• Singer, Zakary S.; Yong, John; et el. (2014) Dynamic Heterogeneity and DNA Methylation in Embryonic Stem Cells; Molecular Cell; Vol. 55; No. 2; 319-331; PMCID PMC4104113; 10.1016/j.molcel.2014.06.029
• Tan, Frederick E. and Elowitz, Michael B. (2014) Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase; Proceedings of the National Academy of Sciences of the United States of America; Vol. 111; No. 17; E1740-E1748; PMCID PMC4035916; 10.1073/pnas.1320873111
• Church, George M.; Elowitz, Michael B.; et el. (2014) Realizing the potential of synthetic biology; Nature Reviews. Molecular Cell Biology; Vol. 15; No. 4; 289-294; PMCID PMC9645560; 10.1038/nrm3767
• Levine, Joe H.; Lin, Yihan; et el. (2013) Functional Roles of Pulsing in Genetic Circuits; Science; Vol. 342; No. 6163; 1193-1200; PMCID PMC4100686; 10.1126/science.1239999
• Kueh, Hao Yuan; Champhekhar, Ameya; et el. (2013) Positive Feedback Between PU.1 and the Cell Cycle Controls Myeloid Differentiation; Science; Vol. 341; No. 6146; 670-673; PMCID PMC3913367; 10.1126/science.1240831
• Young, Jonathan W.; Locke, James C. W.; et el. (2013) Rate of environmental change determines stress response specificity; Proceedings of the National Academy of Sciences of the United States of America; Vol. 110; No. 10; 4140-4145; PMCID PMC3593889; 10.1073/pnas.1213060110
• Rosenthal, Adam Z. and Elowitz, Michael B. (2012) Following evolution of bacterial antibiotic resistance in real time; Nature Genetics; Vol. 44; No. 1; 11-13; 10.1038/ng.1048
• Young, Jonathan W.; Locke, James C. W.; et el. (2012) Measuring single-cell gene expression dynamics in bacteria using fluorescence time-lapse microscopy; Nature Protocols; Vol. 7; No. 1; 80-88; PMCID PMC4161363; 10.1038/nprot.2011.432
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• Locke, James C. W.; Young, Jonathan W.; et el. (2011) Stochastic Pulse Regulation in Bacterial Stress Response; Science; Vol. 334; No. 6054; 366-369; PMCID PMC4100694; 10.1126/science.1208144
• Zheng, Guoan; Lee, Seung Ah; et el. (2011) The ePetri dish, an on-chip cell imaging platform based on subpixel perspective sweeping microscopy (SPSM); Proceedings of the National Academy of Sciences of the United States of America; Vol. 108; No. 41; 16889-16894; PMCID PMC3193234; 10.1073/pnas.1110681108
• Sen, Shaunak; Garcia-Ojalvo, Jordi; et el. (2011) Dynamical Consequences of Bandpass Feedback Loops in a Bacterial Phosphorelay; PLoS ONE; Vol. 6; No. 9; Art. No. e25102; PMCID PMC3182994; 10.1371/journal.pone.0025102
• Nandagopal, Nagarajan and Elowitz, Michael B. (2011) Synthetic Biology: Integrated Gene Circuits; Science; Vol. 333; No. 6047; 1244-1248; PMCID PMC4117316; 10.1126/science.1207084
• Sprinzak, David; Lakhanpal, Amit; et el. (2011) Mutual Inactivation of Notch Receptors and Ligands Facilitates Developmental Patterning; PLoS Computational Biology; Vol. 7; No. 6; Art. No. e1002069; PMCID PMC3111533; 10.1371/journal.pcbi.1002069
• Young, Jonathan W. and Elowitz, Michael B. (2011) Mixed Messages: How Bacteria Resolve Conflicting Signals; Molecular Cell; Vol. 42; No. 4; 405-406; PMCID PMC4117311; 10.1016/j.molcel.2011.05.005
• Elowitz, Michael B. and Lim, Wendell A. (2010) Build life to understand it; Nature; Vol. 468; 889-890; PMCID PMC3068207; 10.1038/468889a
• Acar, Murat; Pando, Bernardo F.; et el. (2010) A General Mechanism for Network-Dosage Compensation in Gene Circuits; Science; Vol. 329; No. 5999; 1656-1660; PMCID PMC3138731; 10.1126/science.1190544
• Eldar, Avigdor and Elowitz, Michael B. (2010) Functional roles for noise in genetic circuits; Nature; Vol. 467; No. 7312; 167-173; PMCID PMC4100692; 10.1038/nature09326
• Cox, Robert Sidney, III; Dunlop, Mary J.; et el. (2010) A synthetic three-color scaffold for monitoring genetic regulation and noise; Journal of Biological Engineering; Vol. 4; Art. No. 10; PMCID PMC2918530; 10.1186/1754-1611-4-10
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• Presser, Aviva; Elowitz, Michael B.; et el. (2008) The evolutionary dynamics of the Saccharomyces cerevisiae protein interaction network after duplication; Proceedings of the National Academy of Sciences of the United States of America; Vol. 105; No. 3; 950-954; PMCID PMC2242688; 10.1073/pnas.0707293105
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