Dunphy, William G.

Combined from CaltechAUTHORS

• Haccard, Olivier and Ciardo, Diletta, et el. (2023) Rif1 restrains the rate of replication origin firing in Xenopus laevis; Communications Biology; Vol. 6; 788; PMCID PMC10387115; 10.1038/s42003-023-05172-8
• Zhang, Yide and Shen, Binglin, et el. (2022) Ultrafast and hypersensitive phase imaging of propagating internodal current flows in myelinated axons and electromagnetic pulses in dielectrics; Nature Communications; Vol. 13; Art. No. 5247; PMCID PMC9448739; 10.1038/s41467-022-33002-8
• Dunphy, William G. (2021) TopBP1 comes into focus; Molecular Cell; Vol. 81; No. 6; 1126-1127; 10.1016/j.molcel.2021.02.027
• Kumagai, Akiko and Dunphy, William G. (2020) Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication; Cell Reports; Vol. 32; No. 12; Art. No. 108178; PMCID PMC7523632; 10.1016/j.celrep.2020.108178
• Lim, Daniel C. and Joukov, Vladimir, et el. (2020) Redox priming promotes Aurora A activation during mitosis; Science Signaling; Vol. 13; No. 641; Art. No. eabb6707; PMCID PMC8514121; 10.1126/scisignal.abb6707
• Lyu, Ke and Kumagai, Akiko, et el. (2019) RPA-coated single-stranded DNA promotes the ETAA1-dependent activation of ATR; Cell Cycle; Vol. 18; No. 8; 898-913; 10.1080/15384101.2019.1598728
• Kumagai, Akiko and Dunphy, William G. (2017) MTBP, the Partner of Treslin, Contains a Novel DNA-Binding Domain, That Is Essential for Proper Initiation of DNA Replication; Molecular Biology of the Cell; Vol. 28; No. 22; 2998-3012; PMCID PMC5662258; 10.1091/mbc.E17-07-0448
• Mu, Ruiling and Tat, John, et el. (2017) CKS Proteins Promote Checkpoint Recovery by Stimulating Phosphorylation of Treslin; Molecular and Cellular Biology; Vol. 37; No. 20; Art. No. e00344; PMCID PMC5615187; 10.1128/MCB.00344-17
• Ryu, Hyunju and Yoshida, Makoto M., et el. (2015) SUMOylation of the C-terminal domain of DNA topoisomerase IIα regulates the centromeric localization of Claspin; Cell Cycle; Vol. 14; No. 17; 2777-2784; PMCID PMC4614044; 10.1080/15384101.2015.1066537
• Guo, Cai and Kumagai, Akiko, et el. (2015) Interaction of Chk1 with Treslin Negatively Regulates the Initiation of Chromosomal DNA Replication; Molecular Cell; Vol. 57; No. 3; 492-505; PMCID PMC4321788; 10.1016/j.molcel.2014.12.003
• Lee, Joon and Dunphy, William G. (2013) The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks; Molecular Biology of the Cell; Vol. 24; No. 9; 1343-1353; PMCID PMC3639046; 10.1091/mbc.E13-01-0025
• Kumar, Sanjay and Yoo, Hae Yong, et el. (2012) Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts; Cell Cycle; Vol. 11; No. 6; 1183-1194; 10.4161/cc.11.6.19636
• Meng, Zheng and Capalbo, Luisa, et el. (2011) Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1; Molecular Biology of the Cell; Vol. 22; No. 16; 2834-2847; PMCID PMC3154880; 10.1091/mbc.E11-01-0048
• Kumagai, Akiko and Shevchenko, Anna, et el. (2011) Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication; Journal of Cell Biology; Vol. 193; No. 6; 995-1007; PMCID PMC3115804; 10.1083/jcb.201102003
• Ramírez-Lugo, Juan S. and Yoo, Hae Yong, et el. (2011) CtIP interacts with TopBP1 and Nbs1 in the response to double-stranded DNA breaks (DSBs) in Xenopus egg extracts; Cell Cycle; Vol. 10; No. 3; 469-480; 10.4161/cc.10.3.14711
• Gold, Daniel A. and Dunphy, William G. (2010) Drf1-dependent Kinase Interacts with Claspin through a Conserved Protein Motif; Journal of Biological Chemistry; Vol. 285; No. 17; 12638-12646; PMCID PMC2857117; 10.1074/jbc.M109.077370
• Lee, Joon and Dunphy, William G. (2010) Rad17 Plays a Central Role in Establishment of the Interaction between TopBP1 and the Rad9-Hus1-Rad1 Complex at Stalled Replication Forks; Molecular Biology of the Cell; Vol. 21; No. 6; 926-935; PMCID PMC2836973; 10.1091/mbc.E09-11-0958
• Wawrousek, Karen E. and Fortini, Barbara K., et el. (2010) Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM; Cell Cycle; Vol. 9; No. 6; 1156-1166
• Kumagai, Akiko and Shevchenko, Anna, et el. (2010) Treslin Collaborates with TopBP1 in Triggering the Initiation of DNA Replication; Cell; Vol. 140; No. 3; 349-359; 10.1016/j.cell.2009.12.049
• Yoo, Hae Yong and Kumagai, Akiko, et el. (2009) The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM; Molecular Biology of the Cell; Vol. 20; No. 9; 2351-2360; PMCID PMC2675615; 10.1091/mbc.E08-12-1190
• Lee, Joon and Kumagai, Akiko, et el. (2007) The Rad9-Hus1-Rad1 Checkpoint Clamp Regulates Interaction of TopBP1 with ATR; Journal of Biological Chemistry; Vol. 282; No. 38; 28036-28044; 10.1074/jbc.M704635200
• Yoo, Hae Yong and Kumagai, Akiko, et el. (2007) Ataxia-telangiectasia Mutated (ATM)-dependent Activation of ATR Occurs through Phosphorylation of TopBP1 by ATM; Journal of Biological Chemistry; Vol. 282; No. 24; 17501-17506; 10.1074/jbc.M701770200
• Kim, Soon-Mi and Kumagai, Akiko, et el. (2005) Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus Egg Extracts Requires Binding of ATRIP to ATR but Not the Stable DNA-binding or Coiled-coil Domains of ATRIP; Journal of Biological Chemistry; Vol. 280; No. 46; 38355-38364; 10.1074/jbc.M508673200
• Lee, Joon and Gold, Daniel A., et el. (2005) Roles of replication fork-interacting and Chk1-activating domains from claspin in a DNA replication checkpoint response; Molecular Biology of the Cell; Vol. 16; No. 11; 5269-5282; PMCID PMC1266425; 10.1091/mbc.E05-07-0671
• Yoo, Hae Yong and Shevchenko, Anna, et el. (2004) Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses; Journal of Biological Chemistry; Vol. 279; No. 51; 53353-53364; 10.1074/jbc.M408026200
• Kumagai, Akiko and Kim, Soo-Mi, et el. (2004) Claspin and the Activated Form of ATR-ATRIP Collaborate in the Activation of Chk1; Journal of Biological Chemistry; Vol. 279; No. 48; 49599-49608; 10.1074/jbc.M408353200
• Li, Wenhui and Kim, Soo-Mi, et el. (2004) Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases; Journal of Cell Biology; Vol. 165; No. 6; 801-812; PMCID PMC2172405; 10.1083/jcb.200402095
• Jeong, Seong-Yun and Kumagai, Akiko, et el. (2003) Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation; Journal of Biological Chemistry; Vol. 278; No. 47; 46782-46788; 10.1074/jbc.M304551200
• Yanow, Stephanie K. and Gold, Daniel A., et el. (2003) Xenopus Drf1, a Regulator of Cdc7, Displays Checkpoint-dependent Accumulation on Chromatin during an S-phase Arrest; Journal of Biological Chemistry; Vol. 278; No. 42; 41083-41092; 10.1074/jbc.M307144200
• Kumagai, Akiko and Dunphy, William G. (2003) Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1; Nature Cell Biology; Vol. 5; No. 2; 161-165; 10.1038/ncb921
• Budde, Priya Prakash and Kumagai, Akiko, et el. (2001) Regulation of Op18 during Spindle Assembly in Xenopus Egg Extracts; Journal of Cell Biology; Vol. 153; No. 1; 149-157; 10.1083/jcb.153.1.149
• Lee, Joon and Kumagai, Akiko, et el. (2001) Positive regulation of Wee1 by Chk1 and 14-3-3 proteins; Molecular Biology of the Cell; Vol. 12; No. 3; 551-563; PMCID PMC30963; 10.1091/mbc.12.3.551
• Xia, Zhenfang and Morales, Julio C., et el. (2001) Negative Cell Cycle Regulation and DNA Damage-inducible Phosphorylation of the BRCT Protein 53BP1; Journal of Biological Chemistry; Vol. 276; No. 4; 2708-2718; 10.1074/jbc.M007665200
• Guo, Zijian and Dunphy, William G. (2000) Response of Xenopus Cds1 in Cell-free Extracts to DNA Templates with Double-stranded Ends; Molecular Biology of the Cell; Vol. 11; No. 5; 1535-1546; PMCID PMC14865
• Patra, Debabrata and Wang, Sophie X., et el. (1999) The Xenopus Suc1/Cks Protein Promotes the Phosphorylation of G2/M Regulators; Journal of Biological Chemistry; Vol. 274; No. 52; 36839-36842
• Kumagai, Akiko and Guo, Zijian, et el. (1998) The Xenopus Chk1 Protein Kinase Mediates a Caffeine-sensitive Pathway of Checkpoint Control in Cell-free Extracts; Journal of Cell Biology; Vol. 142; No. 6; 1559-1569; PMCID PMC2141764; 10.1083/jcb.142.6.1559
• Carpenter, Phillip B. and Dunphy, William G. (1998) Identification of a Novel 81-kDa Component of the Xenopus Origin Recognition Complex; Journal of Biological Chemistry; Vol. 273; No. 28; 24891-24897
• Kumagai, Akiko and Yakowec, Peter S., et el. (1998) 14-3-3 Proteins Act as Negative Regulators of the Mitotic Inducer Cdc25 in Xenopus Egg Extracts; Molecular Biology of the Cell; Vol. 9; No. 2; 345-354; PMCID PMC25261
• Kumagai, Akiko and Dunphy, William G. (1996) Purification and Molecular Cloning of Plx1, a Cdc25-Regulatory Kinase from Xenopus Egg Extracts; Science; Vol. 273; No. 5280; 1377-1380; 10.1126/science.273.5280.1377
• Shou, Wenying and Dunphy, William G. (1996) Cell Cycle Control by Xenopus p28^(Kix1) a Developmentally Regulated Inhibitor of Cyclin-dependent Kinases; Molecular Biology of the Cell; Vol. 7; No. 3; 457-469; PMCID PMC275897
• Carpenter, Phillip B. and Mueller, Paul R., et el. (1996) Role for a Xenopus Orc2-related protein in controlling DNA replication; Nature; Vol. 379; No. 6563; 357-360; 10.1038/379357a0
• Mueller, Paul R. and Coleman, Thomas R., et el. (1995) Myt1: A Membrane-Associated Inhibitory Kinase That Phosphorylates Cdc2 on Both Threonine-14 and Tyrosine-15; Science; Vol. 270; No. 5233; 86-90; 10.1126/science.270.5233.86
• Kumagai, Akiko and Dunphy, William G. (1995) Control of the Cdc2/cyclin B complex in Xenopus egg extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors; Molecular Biology of the Cell; Vol. 6; No. 2; 199-213; PMCID PMC275829
• Mueller, Paul R. and Coleman, Thomas R., et el. (1995) Cell cycle regulation of a Xenopus Wee1-like kinase; Molecular Biology of the Cell; Vol. 6; No. 1; 119-134; PMCID PMC275819