<h1>Dunphy, William</h1> <h2>Article from <a href="https://authors.library.caltech.edu">CaltechAUTHORS</a></h2> <ul> <li>Haccard, Olivier and Ciardo, Diletta, el al. (2023) <a href="https://authors.library.caltech.edu/records/w3vnj-8kd68">Rif1 restrains the rate of replication origin firing in Xenopus laevis</a>; Communications Biology; Vol. 6; 788; PMCID PMC10387115; <a href="https://doi.org/10.1038/s42003-023-05172-8">10.1038/s42003-023-05172-8</a></li> <li>Zhang, Yide and Shen, Binglin, el al. (2022) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20220919-371211400">Ultrafast and hypersensitive phase imaging of propagating internodal current flows in myelinated axons and electromagnetic pulses in dielectrics</a>; Nature Communications; Vol. 13; Art. No. 5247; PMCID PMC9448739; <a href="https://doi.org/10.1038/s41467-022-33002-8">10.1038/s41467-022-33002-8</a></li> <li>Dunphy, William G. (2021) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20210322-100503786">TopBP1 comes into focus</a>; Molecular Cell; Vol. 81; No. 6; 1126-1127; <a href="https://doi.org/10.1016/j.molcel.2021.02.027">10.1016/j.molcel.2021.02.027</a></li> <li>Kumagai, Akiko and Dunphy, William G. (2020) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20200924-091021855">Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication</a>; Cell Reports; Vol. 32; No. 12; Art. No. 108178; PMCID PMC7523632; <a href="https://doi.org/10.1016/j.celrep.2020.108178">10.1016/j.celrep.2020.108178</a></li> <li>Lim, Daniel C. and Joukov, Vladimir, el al. (2020) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20200722-091504306">Redox priming promotes Aurora A activation during mitosis</a>; Science Signaling; Vol. 13; No. 641; Art. No. eabb6707; PMCID PMC8514121; <a href="https://doi.org/10.1126/scisignal.abb6707">10.1126/scisignal.abb6707</a></li> <li>Lyu, Ke and Kumagai, Akiko, el al. (2019) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20190415-103113214">RPA-coated single-stranded DNA promotes the ETAA1-dependent activation of ATR</a>; Cell Cycle; Vol. 18; No. 8; 898-913; <a href="https://doi.org/10.1080/15384101.2019.1598728">10.1080/15384101.2019.1598728</a></li> <li>Kumagai, Akiko and Dunphy, William G. (2017) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20170912-102544473">MTBP, the Partner of Treslin, Contains a Novel DNA-Binding Domain, That Is Essential for Proper Initiation of DNA Replication</a>; Molecular Biology of the Cell; Vol. 28; No. 22; 2998-3012; PMCID PMC5662258; <a href="https://doi.org/10.1091/mbc.E17-07-0448">10.1091/mbc.E17-07-0448</a></li> <li>Mu, Ruiling and Tat, John, el al. (2017) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20170731-094457327">CKS Proteins Promote Checkpoint Recovery by Stimulating Phosphorylation of Treslin</a>; Molecular and Cellular Biology; Vol. 37; No. 20; Art. No. e00344; PMCID PMC5615187; <a href="https://doi.org/10.1128/MCB.00344-17">10.1128/MCB.00344-17</a></li> <li>Ryu, Hyunju and Yoshida, Makoto M., el al. (2015) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20150924-153316094">SUMOylation of the C-terminal domain of DNA topoisomerase IIα regulates the centromeric localization of Claspin</a>; Cell Cycle; Vol. 14; No. 17; 2777-2784; PMCID PMC4614044; <a href="https://doi.org/10.1080/15384101.2015.1066537">10.1080/15384101.2015.1066537</a></li> <li>Guo, Cai and Kumagai, Akiko, el al. (2015) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20150108-104415668">Interaction of Chk1 with Treslin Negatively Regulates the Initiation of Chromosomal DNA Replication</a>; Molecular Cell; Vol. 57; No. 3; 492-505; PMCID PMC4321788; <a href="https://doi.org/10.1016/j.molcel.2014.12.003">10.1016/j.molcel.2014.12.003</a></li> <li>Lee, Joon and Dunphy, William G. (2013) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20130729-141626502">The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks</a>; Molecular Biology of the Cell; Vol. 24; No. 9; 1343-1353; PMCID PMC3639046; <a href="https://doi.org/10.1091/mbc.E13-01-0025">10.1091/mbc.E13-01-0025</a></li> <li>Kumar, Sanjay and Yoo, Hae Yong, el al. (2012) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20120504-100016725">Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts</a>; Cell Cycle; Vol. 11; No. 6; 1183-1194; <a href="https://doi.org/10.4161/cc.11.6.19636">10.4161/cc.11.6.19636</a></li> <li>Meng, Zheng and Capalbo, Luisa, el al. (2011) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20110829-104551403">Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1</a>; Molecular Biology of the Cell; Vol. 22; No. 16; 2834-2847; PMCID PMC3154880; <a href="https://doi.org/10.1091/mbc.E11-01-0048">10.1091/mbc.E11-01-0048</a></li> <li>Kumagai, Akiko and Shevchenko, Anna, el al. (2011) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20110624-094825911">Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication</a>; Journal of Cell Biology; Vol. 193; No. 6; 995-1007; PMCID PMC3115804; <a href="https://doi.org/10.1083/jcb.201102003">10.1083/jcb.201102003</a></li> <li>Ramírez-Lugo, Juan S. and Yoo, Hae Yong, el al. (2011) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20110323-141002762">CtIP interacts with TopBP1 and Nbs1 in the response to double-stranded DNA breaks (DSBs) in Xenopus egg extracts</a>; Cell Cycle; Vol. 10; No. 3; 469-480; <a href="https://doi.org/10.4161/cc.10.3.14711">10.4161/cc.10.3.14711</a></li> <li>Gold, Daniel A. and Dunphy, William G. (2010) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20100517-092639612">Drf1-dependent Kinase Interacts with Claspin through a Conserved Protein Motif</a>; Journal of Biological Chemistry; Vol. 285; No. 17; 12638-12646; PMCID PMC2857117; <a href="https://doi.org/10.1074/jbc.M109.077370">10.1074/jbc.M109.077370</a></li> <li>Wawrousek, Karen E. and Fortini, Barbara K., el al. (2010) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20100406-113337914">Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM</a>; Cell Cycle; Vol. 9; No. 6; 1156-1166</li> <li>Lee, Joon and Dunphy, William G. (2010) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20100406-101055081">Rad17 Plays a Central Role in Establishment of the Interaction between TopBP1 and the Rad9-Hus1-Rad1 Complex at Stalled Replication Forks</a>; Molecular Biology of the Cell; Vol. 21; No. 6; 926-935; PMCID PMC2836973; <a href="https://doi.org/10.1091/mbc.E09-11-0958">10.1091/mbc.E09-11-0958</a></li> <li>Kumagai, Akiko and Shevchenko, Anna, el al. (2010) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20100303-105920203">Treslin Collaborates with TopBP1 in Triggering the Initiation of DNA Replication</a>; Cell; Vol. 140; No. 3; 349-359; <a href="https://doi.org/10.1016/j.cell.2009.12.049">10.1016/j.cell.2009.12.049</a></li> <li>Yoo, Hae Yong and Kumagai, Akiko, el al. (2009) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20090731-081529374">The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM</a>; Molecular Biology of the Cell; Vol. 20; No. 9; 2351-2360; PMCID PMC2675615; <a href="https://doi.org/10.1091/mbc.E08-12-1190">10.1091/mbc.E08-12-1190</a></li> <li>Lee, Joon and Kumagai, Akiko, el al. (2007) <a href="https://resolver.caltech.edu/CaltechAUTHORS:LEEjbc07">The Rad9-Hus1-Rad1 Checkpoint Clamp Regulates Interaction of TopBP1 with ATR</a>; Journal of Biological Chemistry; Vol. 282; No. 38; 28036-28044; <a href="https://doi.org/10.1074/jbc.M704635200">10.1074/jbc.M704635200</a></li> <li>Yoo, Hae Yong and Kumagai, Akiko, el al. (2007) <a href="https://resolver.caltech.edu/CaltechAUTHORS:YOOjbc07">Ataxia-telangiectasia Mutated (ATM)-dependent Activation of ATR Occurs through Phosphorylation of TopBP1 by ATM</a>; Journal of Biological Chemistry; Vol. 282; No. 24; 17501-17506; <a href="https://doi.org/10.1074/jbc.M701770200">10.1074/jbc.M701770200</a></li> <li>Kim, Soon-Mi and Kumagai, Akiko, el al. (2005) <a href="https://resolver.caltech.edu/CaltechAUTHORS:KIMjbc05">Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus Egg Extracts Requires Binding of ATRIP to ATR but Not the Stable DNA-binding or Coiled-coil Domains of ATRIP</a>; Journal of Biological Chemistry; Vol. 280; No. 46; 38355-38364; <a href="https://doi.org/10.1074/jbc.M508673200">10.1074/jbc.M508673200</a></li> <li>Lee, Joon and Gold, Daniel A., el al. (2005) <a href="https://resolver.caltech.edu/CaltechAUTHORS:LEEmbc05">Roles of replication fork-interacting and Chk1-activating domains from claspin in a DNA replication checkpoint response</a>; Molecular Biology of the Cell; Vol. 16; No. 11; 5269-5282; PMCID PMC1266425; <a href="https://doi.org/10.1091/mbc.E05-07-0671">10.1091/mbc.E05-07-0671</a></li> <li>Yoo, Hae Yong and Shevchenko, Anna, el al. (2004) <a href="https://resolver.caltech.edu/CaltechAUTHORS:YOOjbc04">Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses</a>; Journal of Biological Chemistry; Vol. 279; No. 51; 53353-53364; <a href="https://doi.org/10.1074/jbc.M408026200">10.1074/jbc.M408026200</a></li> <li>Kumagai, Akiko and Kim, Soo-Mi, el al. (2004) <a href="https://resolver.caltech.edu/CaltechAUTHORS:KUMjbc04">Claspin and the Activated Form of ATR-ATRIP Collaborate in the Activation of Chk1</a>; Journal of Biological Chemistry; Vol. 279; No. 48; 49599-49608; <a href="https://doi.org/10.1074/jbc.M408353200">10.1074/jbc.M408353200</a></li> <li>Li, Wenhui and Kim, Soo-Mi, el al. (2004) <a href="https://resolver.caltech.edu/CaltechAUTHORS:LIWjcb04">Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases</a>; Journal of Cell Biology; Vol. 165; No. 6; 801-812; PMCID PMC2172405; <a href="https://doi.org/10.1083/jcb.200402095">10.1083/jcb.200402095</a></li> <li>Jeong, Seong-Yun and Kumagai, Akiko, el al. (2003) <a href="https://resolver.caltech.edu/CaltechAUTHORS:JEOjbc03">Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation</a>; Journal of Biological Chemistry; Vol. 278; No. 47; 46782-46788; <a href="https://doi.org/10.1074/jbc.M304551200">10.1074/jbc.M304551200</a></li> <li>Yanow, Stephanie K. and Gold, Daniel A., el al. (2003) <a href="https://resolver.caltech.edu/CaltechAUTHORS:YANjbc03b">Xenopus Drf1, a Regulator of Cdc7, Displays Checkpoint-dependent Accumulation on Chromatin during an S-phase Arrest</a>; Journal of Biological Chemistry; Vol. 278; No. 42; 41083-41092; <a href="https://doi.org/10.1074/jbc.M307144200">10.1074/jbc.M307144200</a></li> <li>Kumagai, Akiko and Dunphy, William G. (2003) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20150401-131436483">Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1</a>; Nature Cell Biology; Vol. 5; No. 2; 161-165; <a href="https://doi.org/10.1038/ncb921">10.1038/ncb921</a></li> <li>Budde, Priya Prakash and Kumagai, Akiko, el al. (2001) <a href="https://resolver.caltech.edu/CaltechAUTHORS:BUDjcb01">Regulation of Op18 during Spindle Assembly in Xenopus Egg Extracts</a>; Journal of Cell Biology; Vol. 153; No. 1; 149-157; <a href="https://doi.org/10.1083/jcb.153.1.149">10.1083/jcb.153.1.149</a></li> <li>Lee, Joon and Kumagai, Akiko, el al. (2001) <a href="https://resolver.caltech.edu/CaltechAUTHORS:LEEmbc01.900">Positive regulation of Wee1 by Chk1 and 14-3-3 proteins</a>; Molecular Biology of the Cell; Vol. 12; No. 3; 551-563; PMCID PMC30963; <a href="https://doi.org/10.1091/mbc.12.3.551">10.1091/mbc.12.3.551</a></li> <li>Xia, Zhenfang and Morales, Julio C., el al. (2001) <a href="https://resolver.caltech.edu/CaltechAUTHORS:XIAjbc01">Negative Cell Cycle Regulation and DNA Damage-inducible Phosphorylation of the BRCT Protein 53BP1</a>; Journal of Biological Chemistry; Vol. 276; No. 4; 2708-2718; <a href="https://doi.org/10.1074/jbc.M007665200">10.1074/jbc.M007665200</a></li> <li>Guo, Zijian and Dunphy, William G. (2000) <a href="https://resolver.caltech.edu/CaltechAUTHORS:GUOmbc00">Response of Xenopus Cds1 in Cell-free Extracts to DNA Templates with Double-stranded Ends</a>; Molecular Biology of the Cell; Vol. 11; No. 5; 1535-1546; PMCID PMC14865</li> <li>Patra, Debabrata and Wang, Sophie X., el al. (1999) <a href="https://resolver.caltech.edu/CaltechAUTHORS:PATjbc99">The Xenopus Suc1/Cks Protein Promotes the Phosphorylation of G2/M Regulators</a>; Journal of Biological Chemistry; Vol. 274; No. 52; 36839-36842</li> <li>Kumagai, Akiko and Guo, Zijian, el al. (1998) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20090918-130239167">The Xenopus Chk1 Protein Kinase Mediates a Caffeine-sensitive Pathway of Checkpoint Control in Cell-free Extracts</a>; Journal of Cell Biology; Vol. 142; No. 6; 1559-1569; PMCID PMC2141764; <a href="https://doi.org/10.1083/jcb.142.6.1559">10.1083/jcb.142.6.1559</a></li> <li>Carpenter, Phillip B. and Dunphy, William G. (1998) <a href="https://resolver.caltech.edu/CaltechAUTHORS:CARjbc98">Identification of a Novel 81-kDa Component of the Xenopus Origin Recognition Complex</a>; Journal of Biological Chemistry; Vol. 273; No. 28; 24891-24897</li> <li>Kumagai, Akiko and Yakowec, Peter S., el al. (1998) <a href="https://resolver.caltech.edu/CaltechAUTHORS:KUMmbc98">14-3-3 Proteins Act as Negative Regulators of the Mitotic Inducer Cdc25 in Xenopus Egg Extracts</a>; Molecular Biology of the Cell; Vol. 9; No. 2; 345-354; PMCID PMC25261</li> <li>Kumagai, Akiko and Dunphy, William G. (1996) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20141216-084027032">Purification and Molecular Cloning of Plx1, a Cdc25-Regulatory Kinase from Xenopus Egg Extracts</a>; Science; Vol. 273; No. 5280; 1377-1380; <a href="https://doi.org/10.1126/science.273.5280.1377">10.1126/science.273.5280.1377</a></li> <li>Shou, Wenying and Dunphy, William G. (1996) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20120209-093522920">Cell Cycle Control by Xenopus p28^(Kix1) a Developmentally Regulated Inhibitor of Cyclin-dependent Kinases</a>; Molecular Biology of the Cell; Vol. 7; No. 3; 457-469; PMCID PMC275897</li> <li>Carpenter, Phillip B. and Mueller, Paul R., el al. (1996) <a href="https://resolver.caltech.edu/CaltechAUTHORS:20150514-080902056">Role for a Xenopus Orc2-related protein in controlling DNA replication</a>; Nature; Vol. 379; No. 6563; 357-360; <a href="https://doi.org/10.1038/379357a0">10.1038/379357a0</a></li> <li>Mueller, Paul R. and Coleman, Thomas R., el al. 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