[ { "id": "authors:1ce00-zhg85", "collection": "authors", "collection_id": "1ce00-zhg85", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20190812-141226810", "type": "conference_item", "title": "On the route to elucidating the relationships between zeolite structure and methanol-to-olefins reaction performance", "author": [ { "family_name": "Davis", "given_name": "Mark Edward", "orcid": "0000-0001-8294-1477", "clpid": "Davis-M-E" } ], "abstract": "The methanol-to-olefins (MTO) reaction produces high value-added light olefins from non-petroleum sources. Acidic zeotypes contg. cages bounded by 8-ring (small pore) windows can effectively catalyze the MTO reaction, since their cages can accommodate the necessary arom. intermediates while letting light olefin products escape. While progress on the understanding the reaction mechanisms of the MTO reaction continue, zeotype structure-MTO reaction property relationships are in their infancy. I discuss our recent work on elucidating how zeolite cage properties primarily det. reaction product distributions and our definition of the cage-defining ring that is well correlated to MTO product distributions. Addnl., I discuss how the acid site proximity and the shape of the cage can influence reaction lifetimes and coking amts. Overall, the goal is to understand desired properties of the zeotype catalyst to give a desired performance.", "publisher": "Caltech Library", "publication_date": "2019-08" }, { "id": "authors:01p7v-n8w22", "collection": "authors", "collection_id": "01p7v-n8w22", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20190812-135709922", "type": "conference_item", "title": "Investigation of the active Bronsted acid site for the DME carbonylation reaction in chabazite-type zeolites", "author": [ { "family_name": "Lusardi", "given_name": "Marcella", "orcid": "0000-0002-7002-4257", "clpid": "Lusardi-M" }, { "family_name": "Davis", "given_name": "Mark EDWARD", "orcid": "0000-0001-8294-1477", "clpid": "Davis-M-E" } ], "abstract": "Chabazite-type (CHA) zeolites (SSZ-13s) are active acid catalysts in the carbonylation of di-Me ether (DME), an important C-C bond forming reaction involved in the conversion of syngas derivs. to valuable chem. intermediates. We observe a max. in the formation rate of Me acetate, the target product, as a function of Si/Al in the SSZ-13s that cannot be explained from the standpoint of total acid site d. While the active sites for this reaction have been better studied in other zeolite topologies (MOR, FER), to date, the origin of activity in CHA remains unclear. To investigate this issue, we synthesized SSZ-13s with a range of Si/Al (5 < Si/Al < 75) to vary both Bronsted acid site d. and siting (e.g., paired vs. isolated), and evaluated the impact of these parameters on the DME carbonylation activity. Further, because the CHA structure has only one T-site, differentiating Bronsted acid sites via 1H NMR may be feasible. Three possible extraframework, monovalent cation sites exist. Only two of these sites are accessible by reactants, reducing the active Bronsted acid site candidates to the proton that sits in the 6-membered ring (MR) window, and the one oriented in the 8MR window. We detect three distinct resonances in the high-spin 1H NMR spectra on dehydrated SSZ-13s. From the reactivity and NMR analyses, coupled with divalent cation exchange expts. for specific titrn. of paired (framework Al sepd. by no more than 3 Si-O units) acid sites, we developed a model for the location of the active site in CHA. Given the unique framework topol. of CHA compared to other active, DME carbonylation zeolite topologies, this investigation provides further insights into this useful C-C bond forming reaction.", "publisher": "Caltech Library", "publication_date": "2019-08" }, { "id": "authors:k62j1-kav22", "collection": "authors", "collection_id": "k62j1-kav22", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180413-084049417", "type": "conference_item", "title": "Synthesis of chiral molecular sieves: A 30 year journey", "author": [ { "family_name": "Davis", "given_name": "Mark", "orcid": "0000-0001-8294-1477", "clpid": "Davis-M-E" } ], "abstract": "Recently, my co-workers and I synthesized an enantiomerically enriched, polycryst. mol. sieve that has the STW framework topol. My journey to prep. a chiral mol. sieve began 30 years ago, and in this presentation, I will chronicle the progress made from start to finish. Over that period of time, advances in synthetic methods, characterization techniques and computer simulations have greatly advanced, and all these advances were used to design, prep. and conclusively prove that an enantiomerically enriched, polycryst. mol. sieve was indeed\nobtained. Addnl., I will make a few comments about what may be possible with chiral mol. sieves in the near future.", "publisher": "Caltech Library", "publication_date": "2018-03" }, { "id": "authors:j757d-y3y23", "collection": "authors", "collection_id": "j757d-y3y23", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180705-100512499", "type": "conference_item", "title": "Cis-trans isomerism and the role of dilution in organic structure direction to relevant zeolite catalysts AEI (SSZ-39) and GME (CIT-9)", "author": [ { "family_name": "Dusselier", "given_name": "Michiel", "orcid": "0000-0002-3074-2318", "clpid": "Dusselier-M" }, { "family_name": "Kang", "given_name": "Jong Hun", "orcid": "0000-0002-4197-9070", "clpid": "Kang-Jong-Hun" }, { "family_name": "Xie", "given_name": "Dan", "orcid": "0000-0003-2467-976X", "clpid": "Xie-Dan" }, { "family_name": "Davis", "given_name": "Mark", "orcid": "0000-0001-8294-1477", "clpid": "Davis-M-E" } ], "abstract": "Zeolites are thriving as functional and stable materials in catalysis, sorption and even specialty applications. Besides their dominant presence in petrochem., their potential in the conversion of renewables and gaseous feedstock is huge (SCR, MTO, methane-partial oxidn.), and often a single framework excels at a specific task. Although novel structures are being reported frequently, for some structurally-relevant topologies, no effective synthetic aluminosilicate recipes are known. Natural or synthetic gmelinite (GME topol.) for example, is nearly always encountered with stacking faults (intergrowths) blocking the main channel and thus limiting porosity for application in catalysis. The search for fault-free synthetic GME has been going on for \u00b1 40 years, because the framework is a 3-dimensional large pore zeolite, with a promising 12x8x8 channel system for relevant hydrocarbon chemistries, e.g. hexane isomerization or reactions where mol. traffic control is vital (compare to LTL). Interestingly, the framework can be entirely constructed by linking d6r composite building units. Here, we present a new route for making GME zeolites, labeled CIT-9, based on the use of a simple org. structure directing agent (OSDA), with a remarkable cis-trans isomeric specificity. Only cis-N,N,3,5-tetramethylpiperidinium hydroxide leads to CIT-9, while the trans form leads to SSZ-39 of the AEI topol. AEI is an interesting cage-contg. zeolite with 8MR small-pore windows, and a documented excellent activity in SCR (Cu ions) and MTO (H+). The selectivity of synthesis also depends on the diln. of the synthesis suspension and thus the concn. of OSDA (selectivity to GME vs AEI in Figure 1) . The origin of both cis/trans and cage vs-channel selectivity is investigated and confirmed from mol. modeling. Finally, in the light of catalysis, the novel GME is studied with rotation electron diffraction and variable temp. XRD, to monitor its faulting and thermal stability. In short, the material is non-faulted, porous, and stable in its K-form. In a side note, the first methanol-to-olefin study with the other produced zeolite, SSZ-39 (AEI) is introduced as well.", "publisher": "Caltech Library", "publication_date": "2018-03" }, { "id": "authors:9g7gj-p2n83", "collection": "authors", "collection_id": "9g7gj-p2n83", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20170505-124940271", "type": "conference_item", "title": "Tweet, for science!: A social media course for scientists at Caltech tackling inreach and outreach online", "author": [ { "family_name": "Wilkins", "given_name": "Olivia", "orcid": "0000-0002-3191-5401", "clpid": "Wilkins-O-H" }, { "family_name": "Davis", "given_name": "Mark E.", "orcid": "0000-0001-8294-1477", "clpid": "Davis-M-E" }, { "family_name": "Mojarad", "given_name": "Sarah", "clpid": "Mojarad-S" } ], "abstract": "The public places greater trust in scientists than in conventional media outlets for communicating science, and yet STEM topics are among the least represented areas on social media platforms. As technol. evolves, so do tools for online communication. Hence it is imperative that\nscientists develop and implement skills to use social media effectively. In Social Media for Scientists at the California Institute of Technol., students are introduced to how social media and science intersect and learn how to use social media for both inreach (engaging each other)\nand outreach (engaging general audiences). In the course, co-taught by a Chem. Engineering professor (Mark E. Davis) and a communications professional (Sarah Mojarad), students explore ethics, misinformation management, branding, and law through case studies, discussion boards, and various social media projects.", "publisher": "Caltech Library", "publication_date": "2017-04" }, { "id": "authors:bf9ja-rwn76", "collection": "authors", "collection_id": "bf9ja-rwn76", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20170502-102605956", "type": "conference_item", "title": "Polymer-Based nanoparticle therapeutics", "author": [ { "family_name": "Davis", "given_name": "Mark E.", "orcid": "0000-0001-8294-1477", "clpid": "Davis-M-E" } ], "abstract": "We have translated three polymer-based nanoparticles into the clinic for use as cancer therapeutics. One of these nanoparticle, exptl. therapeutics was the first to show functional RNA interference (RNAi) in humans. At this time, these nanoparticles have been investigated in over 10 different clin. trials. I will describe how we\ntranslated these nanoparticles from the lab. at Caltech into clin., exptl. therapeutics. In addn. to investigations of polymer-based nanoparticle therapeutics for cancer, we are now concg. on developing polymer-based nanoparticles that cross the blood-brain-barrier. Our recent efforts will be presented.", "publisher": "Caltech Library", "publication_date": "2017-04" }, { "id": "authors:g9s2q-zxp09", "collection": "authors", "collection_id": "g9s2q-zxp09", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20140811-125156249", "type": "conference_item", "title": "New route to glucose-derived terephthalic acid using zeolite catalysts", "author": [ { "family_name": "Pacheco", "given_name": "Joshua J.", "clpid": "Pacheco-J-J" }, { "family_name": "Davis", "given_name": "Mark E.", "orcid": "0000-0001-8294-1477", "clpid": "Davis-M-E" } ], "abstract": "A new series of zeolite-catalyzed Diels-Alder cycloaddn. and dehydrative aromatization reactions between oxygenated furan dienes and ethylene are reported. It is found that pure Lewis-acid zeolites (Sn-BEA) are catalysts for the conversion of 5-substituted furoic acid derivs. and ethylene to 4-substituted benzoic acid derivs. For example, the diene, Me 5-(methoxymethyl)-furan-2-carboxylate, is converted to the dehydrated Diels-Alder product upon reaction with high-pressure (1000 psig) ethylene at 190\u00b0C (selectivity can be over 50%). The arom. product of this reaction, Me 4-(methoxymethyl)benzoate, can be used to produce terephthalic acid or its diester via oxidn. This new reaction pathway opens a completely new route for the prodn. of terephthalic acid starting from glucose-derived HMF (5-hydroxymethyl-2-furfural) and ethylene, and avoids any costly redn. steps.", "publisher": "Caltech Library", "publication_date": "2014-08" }, { "id": "authors:yf45z-0wk18", "collection": "authors", "collection_id": "yf45z-0wk18", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20140505-160524389", "type": "conference_item", "title": "Synthesis and characterization of high-silica LTA produced by direct synthesis using a combination of organic SDAs", "author": [ { "family_name": "Schmidt", "given_name": "Joel E.", "clpid": "Schmidt-J-E" }, { "family_name": "Zones", "given_name": "Stacey I.", "clpid": "Zones-S-I" }, { "family_name": "Davis", "given_name": "Mark E.", "orcid": "0000-0001-8294-1477", "clpid": "Davis-M-E" } ], "abstract": "Recent years have seen resurgence in 8-ring, large cage microporous materials for NO_x conversion, sepns.,\nmethanol-to-olefins reactions, and biomass applications. Systems that are currently being investigated include\nAFX, CHA, LEV and other 8-ring systems. Another promising framework for these applications could be LTA,\nwhich has 8-ring pores and LTA cages (are 11.4 \u00c5 in diam.). Zeolite A is unsuitable for these applications as\nconventional LTA synthesis results in a material with Si/Al=1. Tetramethylammonium cations can be used to\nobtain LTA with ca. Si/Al=3, but these materials are not suitable for the aforementioned applications due to\npoor hydrothermal stability and pore blockage due to cations. Corma and co-workers first reported the\nsynthesis of germanosilicate, pure-silica and aluminosilicate LTA using a supramol. self-assembling org. SDA\nin 2004, denoted ITQ-29. This material showed great promise for applications in sepns., catalysis and low\ndielec. const. membranes. We have recently discovered a facile route to produce LTA using a combination of\norg. SDAs that do not require a supramol. assembly of the orgs. We will describe the synthetic procedure and\nthe properties of materials formed.", "publisher": "Caltech Library", "publication_date": "2014-03" }, { "id": "authors:07msj-4j096", "collection": "authors", "collection_id": "07msj-4j096", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20140506-085532422", "type": "conference_item", "title": "Solid state NMR characterization of Sn-Beta catalysts", "author": [ { "family_name": "Hwang", "given_name": "Son-Jong", "orcid": "0000-0002-3210-466X", "clpid": "Hwang-Son-Jong" }, { "family_name": "Orazov", "given_name": "Marat", "clpid": "Orazov-M" }, { "family_name": "Gounder", "given_name": "Raj", "orcid": "0000-0003-1347-534X", "clpid": "Gounder-R" }, { "family_name": "Bermejo-Deval", "given_name": "Ricardo", "clpid": "Bermejo-Deval-R" }, { "family_name": "Bhawe", "given_name": "Yashodhan", "clpid": "Bhawe-Y" }, { "family_name": "Davis", "given_name": "Mark E.", "orcid": "0000-0001-8294-1477", "clpid": "Davis-M-E" } ], "abstract": "High-resoln. multi-nuclear solid state NMR characterization has been performed to obtain insight into the\nmechanism of glucose reactions with Sn-beta zeolites. Glucose isomerization or epimerization reactions in\nwater and non-aq. environments were examd. thoroughly, and correlations between catalyst structural changes\nand reaction selectivity were the primary focus in this study. In particular, we investigated local structural\nchanges around the catalytically active Sn sites of ^(119)Sn-labeled beta zeolite in different states, including in\ntheir as synthesized form, after calcination in flowing air, after adsorption of sugar mols., and after performing\ncatalytic reaction cycles. Magic angle spinning (MAS) and cross polarization (CP) (either from ^1H or ^(19)F) MAS\n^(119)Sn NMR spectra provided insight into changes in local Sn coordination in the framework of zeolite beta\nunder various conditions. Other NMR results, including ^(13)C NMR of adsorbed glucose or methanol, and ^(19)For\n^(29)Si NMR of zeolite framework, will be used in interpretations of the catalytic reaction mechanisms.", "publisher": "Caltech Library", "publication_date": "2014-03" }, { "id": "authors:w8sm5-cbr31", "collection": "authors", "collection_id": "w8sm5-cbr31", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20140506-085307639", "type": "conference_item", "title": "Upgrading light hydrocarbons: A tandem catalytic system for alkane/alkene coupling", "author": [ { "family_name": "Labinger", "given_name": "Jay A.", "orcid": "0000-0002-1942-9232", "clpid": "Labinger-J-A" }, { "family_name": "Leitch", "given_name": "David C.", "clpid": "Leitch-D-C" }, { "family_name": "Bercaw", "given_name": "John E.", "clpid": "Bercaw-J-E" }, { "family_name": "Deimund", "given_name": "Mark A.", "clpid": "Deimund-M-A" }, { "family_name": "Davis", "given_name": "Mark E.", "orcid": "0000-0001-8294-1477", "clpid": "Davis-M-E" } ], "abstract": "Light hydrocarbons, with relatively low fuel value, are abundant from several sources, including mixed\nalkane/alkene refinery byproduct streams. A tandem system consisting of a compatible combination of a\nhomogeneous alkane dehydrogenation catalyst (known to be kinetically efficient but thermodynamically\ndisfavored at low temps.) with an olefin dimerization catalyst could effect the coupling of an alkane and\nalkene to produce a heavier, more valuable fuel mol. (CnH2n+2 + CnH2n = C2nH4n+2), a reaction that is\nthermodynamically favorable below 250 \u00b0C. We have demonstrated that a homogeneous soln. of the pincerligated\niridium complex t-Bu4[PCP]IrH4 along with Cp*TaCl2(C2H4) couples 1-hexene/n-heptane to C13/C14\nproducts, operating with up to 90% cooperativity. Combining the dehydrogenation catalyst with a\nheterogeneous dimerization catalyst offers a promising approach to a practical process; our progress towards\nthat target will be reported.", "publisher": "Caltech Library", "publication_date": "2014-03" }, { "id": "authors:4mw08-dqe23", "collection": "authors", "collection_id": "4mw08-dqe23", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20140728-075122200", "type": "conference_item", "title": "Award Address (Gabor A. Somorjai Award for Creative Research in Catalysis sponsored by the Gabor A. and Judith K. Somorjai Endowment Fund). New heterogeneous catalysts for converting sugars in aqueous media", "author": [ { "family_name": "Davis", "given_name": "Mark E.", "orcid": "0000-0001-8294-1477", "clpid": "Davis-M-E" } ], "abstract": "The isomerization of glucose into fructose is a large-scale reaction for the prodn. of high-fructose corn syrup, and recently, is\nbeing considered as an intermediate step in the possible route of biomass to fuels and chems. Here, it is shown that a large\npore zeolite that contains tin (Sn-Beta) is able to isomerize glucose to fructose in aq. media with high activity and selectivity.\nSpecifically, a 10 wt% glucose soln. contg. a catalytic amt. of Sn-Beta (1:50 Sn:glucose molar ratio) gives product yields of\napprox. 46% (wt./wt.) glucose, 31% (wt./wt.) fructose, and 9% (wt./wt.) mannose after 30 and 12 min of reaction at 383 K and\n413 K, resp. This reactivity is achieved also when a 45wt% glucose soln. is converted. The Sn-Beta catalyst can be used for\nmultiple cycles, and the reaction stops when the solid is removed, clearly indicating that the catalysis is occurring\nheterogeneously. With isotopically labeled glucose, it is demonstrated that the isomerization reaction catalyzed by Sn-Beta in\nwater proceeds by way of an intramol. hydride shift, confirming that framework tin centers in Sn-Beta act as Lewis acids in aq.\nmedia. The active site is shown to be Sn that has three bonds to framework oxygen atoms, and reaction rates are strongly\ndependent on the hydrophobicity of the mol. sieve. The Sn-Beta catalyst is able to perform the isomerization reaction in highly\nacidic, aq. environments with equiv. activity and product distribution as in media without added acid. This enables Sn-Beta to\ncouple isomerizations with other acid-catalyzed reactions, including hydrolysis/isomerization or isomerization/dehydration\nreaction sequences, including starch to fructose and glucose to 5-hydroxymethylfurfural (HMF). Modifications of Sn-Beta (and\nTi-Beta) have expanded the types of reactions that can be catalyzed. Some of those reactions include the conversion of glucose\nto mannose, glucose to sorbose and lactose to lactulose.", "publisher": "Caltech Library", "publication_date": "2014-03" }, { "id": "authors:8ny3y-pkm13", "collection": "authors", "collection_id": "8ny3y-pkm13", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20131016-132316656", "type": "conference_item", "title": "Sugar rearrangements mediated by Lewis acidic molecular sieves in liquid media", "author": [ { "family_name": "Gounder", "given_name": "Rajamani", "orcid": "0000-0003-1347-534X", "clpid": "Gounder-R" }, { "family_name": "Davis", "given_name": "Mark E.", "orcid": "0000-0001-8294-1477", "clpid": "Davis-M-E" } ], "abstract": "Monosaccharide and disaccharide isomerization and epimerization reactions are catalyzed by Lewis acidic sites\n(M = Sn, Ti, Zr) isolated in silica-based heterogeneous solids, with selectivity and stereochem. specificity that are\ninaccessible to sugar rearrangements involving enolate intermediates catalyzed by bases. Such selectivity and\nspecificity reflect the ability of electrophilic Lewis acid centers to coordinate with oxygenated sugar functional\ngroups and to subsequently mediate intramol. rearrangements of specific H and C atoms, the mechanistic\ndetails of which are probed using D and ^(13)C isotopically-labeled reactants. Here, we discuss recent progress in\nunderstanding the influence of: (i) heteroatom and solvent identity on active site structures and reaction\nmechanisms and (ii) the surrounding silicate environments on the turnover rates of sugar reactions. For\nexample, glucose isomerization to fructose is mediated by Lewis acidic Ti sites isolated within hydrophobic\nand hydrophilic environments provided by cryst. mol. sieves with the Beta topol. and by amorphous silica.\nMeasured first-order rate consts. (per total Ti atom; 373 K), detd. from batch reactor studies under conditions of\nstrict kinetic control, are an order of magnitude higher in liq. water for hydrophobic than for hydrophilic solids.\nMechanistic interpretation of these rate consts. indicates that the environments surrounding Ti centers influence\nfree energy differences between isomerization transition states and two bound solvent mols. that adsorb\ncompetitively at Lewis sites and are most abundant surface intermediates during catalysis. Similar roles of\nhydrophobic pockets confining Lewis centers are found in heterogeneous, homogeneous and enzymic active\nsites that mediate sugar reactions. These findings help clarify the mechanistic details and site requirements for\nsugar conversion on heterogeneous Lewis acid solids, and also provide guidance for active site structural\nmodification to promote desired reaction pathways and thus to develop new heterogeneous catalysts for\nselective sugar conversion in liq. media.", "publisher": "Caltech Library", "publication_date": "2013-09" }, { "id": "authors:q5zvd-qfa30", "collection": "authors", "collection_id": "q5zvd-qfa30", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20120816-073317087", "type": "conference_item", "title": "Tin-containing zeolites are highly active catalysts for the isomerization of glucose in water", "author": [ { "family_name": "Davis", "given_name": "M. E.", "orcid": "0000-0001-8294-1477", "clpid": "Davis-M-E" }, { "family_name": "Moliner", "given_name": "M.", "orcid": "0000-0002-5440-716X", "clpid": "Moliner-Manuel" }, { "family_name": "Rom\u00e1n-Leshkov", "given_name": "Y.", "orcid": "0000-0002-0025-4233", "clpid": "Rom\u00e1n-Leshkov-Y" } ], "abstract": "The isomerization of glucose into fructose is a large-scale reaction for the prodn. of high-fructose corn syrup (HFCS;\nreaction performed by enzyme catalysts), and recently, is being considered as an intermediate step in the possible route\nof biomass to fuels and chems. Here, we show that a large pore zeolite that contains tin (Sn-Beta) is able to isomerize\nglucose to fructose in aq. media with high activity and selectivity. For example, a 10 wt% glucose soln. contg. a catalytic\namt. of Sn-Beta (1:50 Sn:glucose molar ratio) gives product yields of approx. 46% (wt./wt.) glucose, 31% (wt./wt.)\nfructose, and 9% (wt./wt.) mannose after 30 and 12 min of reaction at 383 K and 413 K, resp. The properties of the large\npore zeolite greatly influence the reaction behavior as the reaction does not proceed with a medium pore zeolite, and the\nisomerization activity is considerably lower when the metal centers are incorporated in ordered mesoporous silica (MCM-\n41). The Sn-Beta catalyst can be used for multiple cycles, and the reaction stops when the solid is removed, clearly\nindicating that the catalysis is occurring heterogeneously. Addnl., the Sn-Beta catalyst is able to perform the\nisomerization reaction in highly acidic, aq. environments with equiv. activity and product distribution as in media without\nadded acid. This enables Sn-Beta to couple isomerizations with other acid-catalyzed reactions, including\nhydrolysis/isomerization or isomerization/dehydration reaction sequences (starch to fructose and glucose to 5-\nhydroxymethylfurfural (HMF) demonstrated here). Details of the catalyst prepn. and reaction mechanism will be\npresented as well as discussions on how this new catalyst system could be integrated into larger reaction networks.", "publisher": "Caltech Library", "publication_date": "2010-12" }, { "id": "authors:zg3ry-fxr16", "collection": "authors", "collection_id": "zg3ry-fxr16", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20120815-152834973", "type": "conference_item", "title": "Polymer nanoparticle-based cancer therapeutics: from concept to clinic", "author": [ { "family_name": "Davis", "given_name": "M. E.", "orcid": "0000-0001-8294-1477", "clpid": "Davis-M-E" } ], "abstract": "Nanoparticle-based therapeutics contg. either small mol. anti-cancer agents (IT-101; entered Phase II) or siRNA\n(CALAA-01; in Phase I) are described. The key component in each nanoparticle is a cyclodextrin-contg. polymer that\nendows it with multifunctional behavior. Relationships between nanoparticle design and function in animal models are\nillustrated. Results from clin. trials are presented so show how nanoparticle-based therapeutics can provide interesting\nbehavior in humans.", "publisher": "Caltech Library", "publication_date": "2010-12" } ]