[ { "id": "authors:x7ynf-3mx33", "collection": "authors", "collection_id": "x7ynf-3mx33", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20190812-144643336", "type": "book_section", "title": "Catalysis by Crystalline, Microporous Materials", "book_title": "Catalysis in Chemistry and Biology", "author": [ { "family_name": "Davis", "given_name": "Mark E.", "orcid": "0000-0001-8294-1477", "clpid": "Davis-M-E" } ], "contributor": [ { "family_name": "W\u00fcthrich", "given_name": "Kurt", "clpid": "W\u00fcthrich-K" }, { "family_name": "Grubbs", "given_name": "Robert H.", "clpid": "Grubbs-R-H" }, { "family_name": "de Bocarm\u00e9", "given_name": "Thierry Visart", "clpid": "de-Bocarm\u00e9-T-V" }, { "family_name": "De Wit", "given_name": "Anne", "clpid": "De-Wit-A" } ], "abstract": "The following sections are included: \n\nReaction pathways enabled by crystalline, microporous materials. \n\nExamples of recent contributions from M. E. Davis and collaborators. \n\nExamples of potential future developments with crystalline, microporous materials. \n\nReferences.", "doi": "10.1142/9789813237179_0021", "isbn": "9789813237162", "publisher": "World Scientific", "place_of_publication": "Hackensack, NJ", "publication_date": "2018-08", "pages": "137-140" }, { "id": "authors:mhcb2-zyk22", "collection": "authors", "collection_id": "mhcb2-zyk22", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20160729-120515808", "type": "book_section", "title": "Chapter 8. Polymeric Nanoparticles and Cancer: Lessons Learnt from CRLX101", "book_title": "Nanomedicines", "author": [ { "family_name": "Gritli", "given_name": "Ismael", "clpid": "Gritli-I" }, { "family_name": "Garmey", "given_name": "Edward Graeme", "clpid": "Garmey-E-G" }, { "family_name": "Eliasof", "given_name": "Scott", "clpid": "Eliasof-S" }, { "family_name": "Tellez", "given_name": "Andres", "clpid": "Tellez-A" }, { "family_name": "Davis", "given_name": "Mark E.", "orcid": "0000-0001-8294-1477", "clpid": "Davis-M-E" }, { "family_name": "Yun", "given_name": "Yen", "clpid": "Yun-Yen" } ], "contributor": [ { "family_name": "Braddock", "given_name": "Martin", "clpid": "Braddock-M" } ], "abstract": "CRLX101 (formerly IT-101) is a novel cyclodextrin-based polymer that self-assembles into nanoparticles. CRLX101 is covalently conjugated to the hydrophobic topoisomerase 1 (TOP1)-inhibitor camptothecin (CPT) resulting in stabilized structure and increased water solubility. Extensive preclinical studies of CRLX101 demonstrated delayed renal clearance and a prolonged plasma half-life. The nanoparticle passively accumulates in tumour tissue through the enhanced permeability and retention effect and slowly releases active CPT leading to enhanced TOP1 inhibition, potential hypoxia inducible factor-1\u03b1 (HIF-1\u03b1) effect, cancer stem cell targeting, and increased antitumour activity against multiple human tumour xenografts. More than 200 human cancer patients have been treated with CRLX101 in phase I/IIa and phase II clinical trials. In this chapter we explore a wide range of anti-cancer nanotherapeutic strategies to inhibit TOP1, HIF-1\u03b1 and cancer stem cells. Moreover, we discuss the therapeutic value of combining HIF-1\u03b1 inhibition with antiangiogenics. Finally, we return to CRLX101 and cover in detail the latest preclinical and clinical evaluations and discuss future directions.", "doi": "10.1039/9781782622536-00199", "isbn": "978-1-84973-947-4", "publisher": "Royal Society of Chemistry", "place_of_publication": "Cambridge, UK", "publication_date": "2016-04-28", "pages": "199-232" }, { "id": "authors:jb892-4a220", "collection": "authors", "collection_id": "jb892-4a220", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180405-153019952", "type": "book_section", "title": "Zeolite Synthesis: Can It Be Designed?", "book_title": "Interfacial Design and Chemical Sensing", "author": [ { "family_name": "Davis", "given_name": "Mark E.", "orcid": "0000-0001-8294-1477", "clpid": "Davis-M-E" } ], "abstract": "The possibility of designing zeolites by their controlled synthesis is discussed. The feasibility of creating pore architectures through the design of organic structure-directing agents is described for high-silica zeolites. The first example of such a design is presented. A strategy for building pure-silica zeolites from molecular precursors is outlined. It is concluded that the total design of zeolite structures through their designed synthesis is not currently obtainable but information providing \"pieces to this puzzle\" are quickly being assembled.", "doi": "10.1021/bk-1994-0561.ch003", "isbn": "9780841229310", "publisher": "American Chemical Society", "place_of_publication": "Washington, DC", "publication_date": "1994-07-16", "pages": "27-37" }, { "id": "authors:fqp3s-qwe78", "collection": "authors", "collection_id": "fqp3s-qwe78", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180405-131939192", "type": "book_section", "title": "Shape-Selective Catalysis with Zeolites and Molecular Sieves", "book_title": "Selectivity in Catalysis", "author": [ { "family_name": "Khouw", "given_name": "Charles B.", "clpid": "Khuow-C-B" }, { "family_name": "Davis", "given_name": "Mark E.", "orcid": "0000-0001-8294-1477", "clpid": "Davis-M-E" } ], "abstract": "The types of shape selective catalysis that occur in zeolites and molecular sieves are reviewed. Specifically, primary and secondary acid catalyzed shape selectivity and encapsulated metal ion and zero valent metal particle catalyzed shape selectivity are discussed. Future trends in shape selective catalysis, such as the use of large pore zeolites and electro- and photo-chemically driven reactions, are outlined. Finally, the possibility of using zeolites as chiral shape selective catalysts is discussed.", "doi": "10.1021/bk-1993-0517.ch014", "isbn": "9780841225190", "publisher": "American Chemical Society", "place_of_publication": "Washington, DC", "publication_date": "1993-05-05", "pages": "206-221" }, { "id": "authors:bn62n-d6d93", "collection": "authors", "collection_id": "bn62n-d6d93", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180405-131939450", "type": "book_section", "title": "Reactions of meta-Diisopropylbenzene on Acid Molecular Sieves", "book_title": "Selectivity in Catalysis", "author": [ { "family_name": "Kim", "given_name": "Man-Hoe", "clpid": "Kim-Man-Hoe" }, { "family_name": "Chen", "given_name": "Cong-Yan", "clpid": "Chen-Cong-Yan" }, { "family_name": "Davis", "given_name": "Mark E.", "orcid": "0000-0001-8294-1477", "clpid": "Davis-M-E" } ], "abstract": "Meta-diisopropylbenzene is reacted with propylene over the acid form of the molecular sieves SAPO-5, mordenite, offretite, beta, hexagonal and cubic faujasite (EMT and FAU), L, SAPO-37, and an amorphous silica-alumina at temperatures around 463 K in a flow-type fixed-bed reactor. A small amount of cracking is observed. However, the main reactions of meta-diisopropylbenzene are isomerization and alkylation. It is proposed that this alkylation can be used as a new test reaction to characterize the effective size of the voids in larger pore (12 T-atom rings or above) molecular sieves by measuring the weight ratio of 1,3,5- to 1,2,4-triisopropylbenzene formed. In most cases, this ratio increases with the increasing effective void size of the molecular sieves in the order: SAPO-5 < mordenite < offretite < beta < EMT = FAU < L < SAPO-37 < amorphous silica-alumina.", "doi": "10.1021/bk-1993-0517.ch015", "isbn": "9780841225190", "publisher": "American Chemical Society", "place_of_publication": "Washington, DC", "publication_date": "1993-05-05", "pages": "222-232" }, { "id": "authors:09hqj-pqc73", "collection": "authors", "collection_id": "09hqj-pqc73", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180405-140055514", "type": "book_section", "title": "Preface", "book_title": "Selectivity in Catalysis", "author": [ { "family_name": "Davis", "given_name": "Mark E.", "orcid": "0000-0001-8294-1477", "clpid": "Davis-M-E" }, { "family_name": "Suib", "given_name": "Steven L.", "clpid": "Suib-S-L" } ], "abstract": "[no abstract]", "doi": "10.1021/bk-1993-0517.pr001", "isbn": "9780841225190", "publisher": "American Chemical Society", "place_of_publication": "Washington, DC", "publication_date": "1993-05-05", "pages": "xi" }, { "id": "authors:4dmdg-0s688", "collection": "authors", "collection_id": "4dmdg-0s688", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180405-140055751", "type": "book_section", "title": "Selective Oxidation of Alkanes, Alkenes, and Phenol with Aqueous H_2O_2 on Titanium Silicate Molecular Sieves", "book_title": "Catalytic Selective Oxidation", "author": [ { "family_name": "Khouw", "given_name": "C. B.", "clpid": "Khuow-c-B" }, { "family_name": "Li", "given_name": "H. X.", "clpid": "Li-H-X" }, { "family_name": "Dartt", "given_name": "C. B.", "clpid": "Dartt-C-B" }, { "family_name": "Davis", "given_name": "M. E.", "orcid": "0000-0001-8294-1477", "clpid": "Davis-M-E" } ], "abstract": "Titanium containing pure-silica ZSM-5 (TS-1) materials are synthesized using different methods. The activity of the titanium containing catalysts for the oxidation of alkanes, alkenes and phenol at temperatures below 100 \u00b0C using aqueous H_2O_2 as oxidant is reported. The relationships between the physicochemical and catalytic properties of these titanium silicates are discussed. The effects of added aluminum and sodium on the catalytic activity of TS-1 are described. The addition of sodium during the synthesis of TS-1 is detrimental to the catalytic activity while sodium incorporation into preformed TS-1 is not. The framework substitution of aluminum for silicon appears to decrease the amount of framework titanium.", "doi": "10.1021/bk-1993-0523.ch020", "isbn": "9780841226371", "publisher": "American Chemical Society", "place_of_publication": "Washington, DC", "publication_date": "1993-05-05", "pages": "273-280" } ]