Chan, David

Combined from CaltechAUTHORS

• Castellaneta, Andrea and Losito, Ilario, el al. (2024) Lipidomics reveals the reshaping of the mitochondrial phospholipid profile in cells lacking OPA1 and Mitofusins; Journal of Lipid Research; 100563; 10.1016/j.jlr.2024.100563
• Yamashita, Shun-ichi and Sugiura, Yuki, el al. (2024) Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species; Cell Death & Differentiation; Vol. 31; No. 5; 651-661; PMCID PMC11094013; 10.1038/s41418-024-01280-y
• Chakrabarty, Yogaditya and Yang, Zheng, el al. (2024) The HRI branch of the integrated stress response selectively triggers mitophagy; Molecular Cell; Vol. 84; No. 6; 1090-1100.e6; PMCID PMC11062084; 10.1016/j.molcel.2024.01.016
• Yang, Zheng and Chan, David C. (2023) Control of mitochondrial dynamics by a fusogenic lipid; Trends in Cell Biology; Vol. 33; No. 12; 1005-1006; PMCID PMC10841390; 10.1016/j.tcb.2023.10.006
• Rosencrans, William M. and Chan, David C. (2023) Fusion activators enhance mitochondrial function; Mitochondrial Communications; Vol. 1; 33-34; PMCID PMC10956541; 10.1016/j.mitoco.2023.03.001
• Fry, Michelle Y. and Navarro, Paula P., el al. (2023) In situ architecture of Opa1-dependent mitochondrial cristae remodeling; 10.1101/2023.01.16.524176
• Murata, Daisuke and Grunseich, Christopher, el al. (2023) A Heterozygous Mutation in MFF Associated with a Mild Mitochondrial Phenotype; Journal of Neuromuscular Diseases; Vol. 10; No. 1; 107-118; 10.3233/jnd-221532
• Dai, Wenting and Wang, Zhichao, el al. (2022) Metabolic reprogramming in the OPA1-deficient cells; Cellular and Molecular Life Sciences; Vol. 79; No. 10; Art. No. 517; 10.1007/s00018-022-04542-5
• Yang, Huan and Sibilla, Caroline, el al. (2022) Clueless/CLUH regulates mitochondrial fission by promoting recruitment of Drp1 to mitochondria; Nature Communications; Vol. 13; No. 1; Art. No. 1582; 10.1038/s41467-022-29071-4
• Wareham, Lauren K. and Liddelow, Shane A., el al. (2022) Solving neurodegeneration: common mechanisms and strategies for new treatments; Molecular Neurodegeneration; Vol. 17; Art. No. 23; PMCID PMC8935795; 10.1186/s13024-022-00524-0
• Sonn, Seong Keun and Seo, Seungwoon, el al. (2021) ER-associated CTRP1 regulates mitochondrial fission via interaction with DRP1; Experimental and Molecular Medicine; Vol. 53; 1769-1780; PMCID PMC8639813; 10.1038/s12276-021-00701-z
• Varuzhanyan, Grigor and Ladinsky, Mark S., el al. (2021) Fis1 ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation; Development; Vol. 148; No. 16; Art. No. dev199686; PMCID PMC8380467; 10.1242/dev.199686
• Varuzhanyan, Grigor and Chen, Hsiuchen, el al. (2021) Mitochondrial fission factor (Mff) is required for organization of the mitochondrial sheath in spermatids; Biochimica et Biophysica Acta - General Subjects; Vol. 1865; No. 5; Art. No. 129845; PMCID PMC7904653; 10.1016/j.bbagen.2021.129845
• Wang, Ruohan and Mishra, Prashant, el al. (2021) Identification of new OPA1 cleavage site reveals that short isoforms regulate mitochondrial fusion; Molecular Biology of the Cell; Vol. 32; No. 2; 157-168; PMCID PMC8120690; 10.1091/mbc.e20-09-0605
• Shin, Chun-Shik and Meng, Shuxia, el al. (2021) LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding; Nature Communications; Vol. 12; Art. No. 265; PMCID PMC7801493; 10.1038/s41467-020-20597-z
• Kato, Mitsuo and Abdollahi, Maryam, el al. (2021) miR-379 deletion ameliorates features of diabetic kidney disease by enhancing adaptive mitophagy via FIS1; Communications Biology; Vol. 4; Art. No. 30; PMCID PMC7782535; 10.1038/s42003-020-01516-w
• Adachi, Yoshihiro and Kato, Takashi, el al. (2020) Drp1 Tubulates the ER in a GTPase-Independent Manner; Molecular Cell; Vol. 80; No. 4; 621-632; PMCID PMC7680448; 10.1016/j.molcel.2020.10.013
• Varuzhanyan, Grigor and Chan, David C. (2020) Mitochondrial dynamics during spermatogenesis; Journal of Cell Science; Vol. 133; No. 14; Art. No. jcs235937; PMCID PMC7375475; 10.1242/jcs.235937
• Chan, David C. (2020) Mitochondrial Dynamics and Its Involvement in Disease; Annual Review of Pathology: Mechanisms of Disease; Vol. 15; 235-259; 10.1146/annurev-pathmechdis-012419-032711
• Mishra, Prashant and Zhang, Ting, el al. (2019) Mitochondrial Respiratory Measurements in Patient-derived Fibroblasts; Bio-protocol; Vol. 9; No. 23; Art. No. e3446; PMCID PMC7853990; 10.21769/bioprotoc.3446
• Li, Yu-Jie and Cao, Yu-Lu, el al. (2019) Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset; Nature Communications; Vol. 10; Art. No. 4914; PMCID PMC6820788; 10.1038/s41467-019-12912-0
• Varuzhanyan, Grigor and Rojansky, Rebecca, el al. (2019) Mitochondrial fusion is required for spermatogonial differentiation and meiosis; eLife; Vol. 8; Art. No. e51601; PMCID PMC6805159; 10.7554/elife.51601
• Kehr, Andrew D. and Meng, Shuxia, el al. (2019) Advances in the Structural and Biochemical Determination of Several Dynamin-Like GTPases; Biophysical Journal; Vol. 116; No. 3; 473a; 10.1016/j.bpj.2018.11.2552
• Del Dotto, Valentina and Fogazza, Mario, el al. (2018) Deciphering OPA1 mutations pathogenicity by combined analysis of human, mouse and yeast cell models; Biochimica et Biophysica Acta - Molecular Basis of Disease; Vol. 1864; No. 10; 3496-3514; 10.1016/j.bbadis.2018.08.004
• Guo, Yuxuan and Jardin, Blake D., el al. (2018) Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor; Nature Communications; Vol. 9; Art. No. 3837; PMCID PMC6155060; 10.1038/s41467-018-06347-2
• Ryan, Conor S. and Fine, Anthony L., el al. (2018) De Novo DNM1L Variant in a Teenager With Progressive Paroxysmal Dystonia and Lethal Super-refractory Myoclonic Status Epilepticus; Journal of Child Neurology; Vol. 33; No. 10; 651-658; 10.1177/0883073818778203
• Cha, Moon Yong and Chen, Hsiuchen, el al. (2018) Removal of the Mitochondrial Fission Factor Mff Exacerbates Neuronal Loss and Neurological Phenotypes in a Huntington's Disease Mouse Model; PLOS Currents; PMCID PMC6149597; 10.1371/currents.hd.a4e15b80c4915c828d39754942c6631f
• Jian, Fenglei and Chen, Dan, el al. (2018) Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology; Cell Reports; Vol. 23; No. 10; 2989-3005; 10.1016/j.celrep.2018.05.015
• Nemani, Neeharika and Carvalho, Edmund, el al. (2018) MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca^(2+) Stress; Cell Reports; Vol. 23; No. 4; 1005-1019; PMCID PMC5973819; 10.1016/j.celrep.2018.03.098
• Chan, David C. (2018) Mitochondrial fusion and fission in health and disease; Molecular Genetics and Metabolism; Vol. 123; No. 3; 196; 10.1016/j.ymgme.2017.12.430
• Chan, David (2017) Molecular Analysis Of Mitochondrial Dynamics; Free Radical Biology and Medicine; Vol. 112; No. S1; 17; 10.1016/j.freeradbiomed.2017.10.371
• Li, J. and Lancaster, E., el al. (2017) A Rat Model of CMT2A Develops a Progressive Neuropathy; Journal of the Peripheral Nervous System; Vol. 22; No. 3; 331; 10.1111/jns.12225
• Chen, Hsiuchen and Chan, David C. (2017) Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells; Cell Metabolism; Vol. 26; No. 1; 39-48; PMCID PMC5539982; 10.1016/j.cmet.2017.05.016
• Liu, Raymond and Chan, David C. (2017) OPA1 and cardiolipin team up for mitochondrial fusion; Nature Cell Biology; Vol. 19; No. 7; 760-762; PMCID PMC5757513; 10.1038/ncb3565
• Del Dotto, Valentina and Mishra, Prashant, el al. (2017) OPA1 Isoforms in the Hierarchical Organization of Mitochondrial Functions; Cell Reports; Vol. 19; No. 12; 2557-2571; 10.1016/j.celrep.2017.05.073
• Shin, Chun-Shik and Mishra, Prashant, el al. (2017) The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility; Nature Communications; Vol. 8; Art. No. 15074; PMCID PMC5413954; 10.1038/ncomms15074
• Zhang, Ting and Mishra, Prashant, el al. (2017) Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutants; eLife; Vol. 6; Art. No. e17834; PMCID PMC5360448; 10.7554/eLife.17834
• Cao, Yu-Lu and Meng, Shuxia, el al. (2017) MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion; Nature; Vol. 542; No. 7641; 372-376; PMCID PMC5319402; 10.1038/nature21077
• Chen, Hsiuchen and Chan, David (2017) Control of Mitochondrial Function by Fusion and Fission; Biophysical Journal; Vol. 112; No. 3, Supp. 1; 179a; 10.1016/j.bpj.2016.11.994
• Huang, R. E. and Chan, D. C. (2016) Investigating the roles of Mulan and Fis1 in Mitophagy; Molecular Biology of the Cell; Vol. 27; Art. No. P2161
• Rojansky, Rebecca and Cha, Moon-Yong, el al. (2016) Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1; eLife; Vol. 5; Art. No. e17896; PMCID PMC5127638; 10.7554/eLife.17896
• Mishra, Prashant and Varuzhanyan, Grigor, el al. (2016) Regulation of mitochondrial compartmentalization in skeletal muscle; Mitochondrion; Vol. 31; 96; 10.1016/j.mito.2016.08.010
• Cheng, Chun-Ting and Kuo, Ching-Ying, el al. (2016) Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells; Cancer Research; Vol. 76; No. 17; 5006-5018; PMCID PMC5316485; 10.1158/0008-5472.CAN-15-2921
• Fahrner, Jill A. and Liu, Raymond, el al. (2016) A novel de novo dominant negative mutation in DNM1L impairs mitochondrial fission and presents as childhood epileptic encephalopathy; American Journal of Medical Genetics Part A; Vol. 170; No. 8; 2002-2011; PMCID PMC5100740; 10.1002/ajmg.a.37721
• Mishra, Prashant and Chan, David C. (2016) Metabolic regulation of mitochondrial dynamics; Journal of Cell Biology; Vol. 212; No. 4; 379-387; PMCID PMC4754720; 10.1083/jcb.201511036
• Toyama, Erin Quan and Herzig, Sebastien, el al. (2016) AMP-activated protein kinase mediates mitochondrial fission in response to energy stress; Science; Vol. 351; No. 6270; 275-281; PMCID PMC4852862; 10.1126/science.aab4138
• Mishra, Prashant and Varuzhanyan, Grigor, el al. (2015) Mitochondrial Dynamics Is a Distinguishing Feature of Skeletal Muscle Fiber Types and Regulates Organellar Compartmentalization; Cell Metabolism; Vol. 22; No. 6; 1033-1044; PMCID PMC4670593; 10.1016/j.cmet.2015.09.027
• Liu, Raymond and Chan, David C. (2015) The mitochondrial fission receptor Mff selectively recruits oligomerized Drp1; Molecular Biology of the Cell; Vol. 26; No. 24; 4466-4477; PMCID PMC4666140; 10.1091/mbc.E15-08-0591
• Chen, Hsiuchen and Ren, Shuxun, el al. (2015) Titration of mitochondrial fusion rescues Mff-deficient cardiomyopathy; Journal of Cell Biology; Vol. 211; No. 4; 795-805; PMCID PMC4657172; 10.1083/jcb.201507035
• Hashimoto, Masami and Bacman, Sandra R., el al. (2015) MitoTALENs: A general approach to reduce mutant mtDNA loads and restore oxidative phosphorylation function in mitochondrial diseases; Molecular Therapy; Vol. 23; No. 10; 1592-1599; PMCID PMC4817924; 10.1038/mt.2015.126
• Losón, Oliver C. and Meng, Shuxia, el al. (2015) Crystal structure and functional analysis of MiD49, a receptor for the mitochondrial fission protein Drp1; Protein Science; Vol. 24; No. 3; 386-394; PMCID PMC4353364; 10.1002/pro.2629
• Carelli, Valerio and Chan, David C. (2014) Mitochondrial DNA: Impacting Central and Peripheral Nervous Systems; Neuron; Vol. 84; No. 6; 1126-1142; PMCID PMC4271190; 10.1016/j.neuron.2014.11.022
• Mishra, Prashant and Chan, David C. (2014) Mitochondrial dynamics and inheritance during cell division, development and disease; Nature Reviews. Molecular Cell Biology; Vol. 15; No. 10; 634-646; PMCID PMC4250044; 10.1038/nrm3877
• Chan, Nickie C. and den Besten, Willem, el al. (2014) Degradation of the Deubiquitinating Enzyme USP33 is Mediated by p97 and the Ubiquitin Ligase HERC2; Journal of Biological Chemistry; Vol. 289; No. 28; 19789-19798; PMCID PMC4094088; 10.1074/jbc.M114.569392
• Mishra, Prashant and Carelli, Valerio, el al. (2014) Proteolytic Cleavage of Opa1 Stimulates Mitochondrial Inner Membrane Fusion and Couples Fusion to Oxidative Phosphorylation; Cell Metabolism; Vol. 19; No. 4; 630-641; PMCID PMC4018240; 10.1016/j.cmet.2014.03.011
• Losn, Oliver and Rome, Michael, el al. (2014) Regulation of mitochondrial fission by MiD51; FASEB Journal; Vol. 28; No. 1; 757.1
• Losón, Oliver C. and Liu, Raymond, el al. (2014) The Mitochondrial Fission Receptor MiD51 Requires ADP as a Cofactor; Structure; Vol. 22; No. 3; 367-377; PMCID PMC4066849; 10.1016/j.str.2014.01.001
• Samant, Sadhana A. and Zhang, Hannah J., el al. (2014) SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress; Molecular and Cellular Biology; Vol. 34; No. 5; 807-819; PMCID PMC4023816; 10.1128/MCB.01483-13
• Marinov, Georgi K. and Wang, Yun E., el al. (2014) Evidence for Site-Specific Occupancy of the Mitochondrial Genome by Nuclear Transcription Factors; PLoS ONE; Vol. 9; No. 1; Art. No. e84713; PMCID PMC3896368; 10.1371/journal.pone.0084713
• Ngo, Huu B. and Lovely, Geoffrey A., el al. (2014) Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional activation; Nature Communications; Vol. 5; No. 1; Art. No. 3077; PMCID PMC3936014; 10.1038/ncomms4077
• Pham, Anh H. and Chan, David C. (2014) Analyzing Mitochondrial Dynamics in Mouse Organotypic Slice Cultures; ISBN 9780128016152; Mitochondrial Function; 111-129; 10.1016/B978-0-12-801415-8.00007-2
• Wang, Yun E. and Marinov, Georgi K., el al. (2013) Genome-Wide Analysis Reveals Coating of the Mitochondrial Genome by TFAM; PLoS ONE; Vol. 8; No. 8; Art. No. e74513; PMCID PMC3753274; 10.1371/journal.pone.0074513
• Losón, Oliver Calvin and Chen, Hsiuchen, el al. (2013) Fis1, Mff, MiD49 and MiD51 facilitate Drp1 recruitment for mitochondrial fission; FASEB Journal; Vol. 27; Art. No. 582.2
• Losón, Oliver C. and Song, Zhiyin, el al. (2013) Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission; Molecular Biology of the Cell; Vol. 24; No. 5; 659-667; PMCID PMC3583668; 10.1091/mbc.E12-10-0721
• Kim, Kook Hwan and Jeong, Yeon Taek, el al. (2013) Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine; Nature Medicine; Vol. 19; No. 1; 83-92; 10.1038/nm.3014
• Pham, Anh H. and Meng, Shuxia, el al. (2012) Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit; Human Molecular Genetics; Vol. 21; No. 22; 4817-4826; PMCID PMC3607482; 10.1093/hmg/dds311
• Pham, Anh H. and McCaffery, J. Michael, el al. (2012) Mouse lines with photo-activatable mitochondria to study mitochondrial dynamics; Genesis; Vol. 50; No. 11; 833-843; PMCID PMC3508687; 10.1002/dvg.22050
• Chan, David C. (2012) Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health; Annual Review of Genetics; Vol. 46; 265-287; 10.1146/annurev-genet-110410-132529
• Gautier, Clemente A. and Glaime, Emilie, el al. (2012) Regulation of mitochondrial permeability transition pore by PINK1; Molecular Neurodegeneration; Vol. 7; No. 1; Art. No. 22; PMCID PMC3405481; 10.1186/1750-1326-7-22
• Li, Jia and Liu, Xiaolei, el al. (2012) Lysocardiolipin acyltransferase 1 (ALCAT1) controls mitochondrial DNA fidelity and biogenesis through modulation of MFN2 expression; Proceedings of the National Academy of Sciences of the United States of America; Vol. 109; No. 18; 6975-6890; PMCID PMC3345005; 10.1073/pnas.1120043109
• Klionsky, Daniel J. and Chan, David C. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy; Autophagy; Vol. 8; No. 4; 445-544; PMCID PMC3404883; 10.4161/auto.19496
• Chan, David and Ngo, Huu B., el al. (2012) Dynamics of mitochondria and mitochondrial DNA; FASEB Journal; Vol. 26; Art. No. 103.2
• Zhang, Yan and Chan, Nickie C., el al. (2012) Crystal Structure of Mitochondrial Fission Complex Reveals Scaffolding Function for Mitochondrial Division 1 (Mdv1) Coiled Coil; Journal of Biological Chemistry; Vol. 287; No. 13; 9855-9861; PMCID PMC3323041; 10.1074/jbc.M111.329359
• Chan, David C. and Schon, Eric A. (2012) Eliminating Mitochondrial DNA from Sperm; Developmental Cell; Vol. 22; No. 3; 469-470; PMCID PMC3995028; 10.1016/j.devcel.2012.02.008
• Ngo, Huu B. and Kaiser, Jens T., el al. (2011) The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNA; Nature Structural & Molecular Biology; Vol. 18; No. 11; 1290-1296; PMCID PMC3210390; 10.1038/nsmb.2159
• Chan, Nickie C. and Chan, David C. (2011) Parkin uses the UPS to ship off dysfunctional mitochondria; Autophagy; Vol. 7; No. 7; 771-772; PMCID PMC3973655; 10.4161/auto.7.7.15453
• Chan, Nickie C. and Salazar, Anna M., el al. (2011) Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy; Human Molecular Genetics; Vol. 20; No. 9; 1726-1737; PMCID PMC3071670; 10.1093/hmg/ddr048
• Aravin, Alexei A. and Chan, David C. (2011) piRNAs Meet Mitochondria; Developmental Cell; Vol. 20; No. 3; 287-288; 10.1016/j.devcel.2011.03.003
• Chen, Hsiuchen and Chan, David C. (2010) Physiological functions of mitochondrial fusion; Annals of the New York Academy of Sciences; Vol. 1201; 21-25; 10.1111/j.1749-6632.2010.05615.x
• Ban, Tadato and Heymann, Jürgen A. W., el al. (2010) OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation; Human Molecular Genetics; Vol. 19; No. 11; 2113-2122; PMCID PMC2865371; 10.1093/hmg/ddq088
• Chen, Hsiuchen and Vermulst, Marc, el al. (2010) Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations; Cell; Vol. 141; No. 2; 280-289; PMCID PMC2876819; 10.1016/j.cell.2010.02.026
• Chen, Hsiuchen and Chan, David C. (2009) Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases; Human Molecular Genetics; Vol. 18; No. 2; R169-R176; 10.1093/hmg/ddp326
• Song, Zhiyin and Ghochani, Mariam, el al. (2009) Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion; Molecular Biology of the Cell; Vol. 20; No. 15; 3525-3532; PMCID PMC2719570; 10.1091/mbc.E09-03-0252
• Tondera, Daniel and Grandemange, Stephanie, el al. (2009) SLP-2 is required for stress-induced mitochondrial hyperfusion; EMBO Journal; Vol. 28; No. 11; 1589-1600; PMCID PMC2693158; 10.1038/emboj.2009.89
• Detmer, Scott A. and Vande Velde, Christine, el al. (2008) Hindlimb gait defects due to motor axon loss and reduced distal muscles in a transgenic mouse model of Charcot–Marie–Tooth type 2A; Human Molecular Genetics; Vol. 17; No. 3; 367-375; 10.1093/hmg/ddm314
• Zhang, Yan and Chan, David C. (2007) Structural basis for recruitment of mitochondrial fission complexes by Fis1; Proceedings of the National Academy of Sciences of the United States of America; Vol. 104; No. 47; 18526-18530; PMCID PMC2141810; 10.1073/pnas.0706441104
• Detmer, Scott A. and Chan, David C. (2007) Functions and dysfunctions of mitochondrial dynamics; Nature Reviews. Molecular Cell Biology; Vol. 8; No. 11; 870-879; 10.1038/nrm2275
• Song, Zhiyin and Chen, Hsiuchen, el al. (2007) OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L; Journal of Cell Biology; Vol. 178; No. 5; 749-755; PMCID PMC2064540; 10.1083/jcb.200704110
• Chen, Hsiuchen and McCaffery, J. Michael, el al. (2007) Mitochondrial Fusion Protects against Neurodegeneration in the Cerebellum; Cell; Vol. 130; No. 3; 548-562; 10.1016/j.cell.2007.06.026
• Chan, David C. (2007) Mitochondrial Dynamics in Disease; New England Journal of Medicine; Vol. 356; No. 17; 1707-1709; 10.1056/NEJMp078040
• Detmer, Scott A. and Chan, David C. (2007) Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations; Journal of Cell Biology; Vol. 170; No. 4; 405-414; PMCID PMC2063976; 10.1083/jcb.200611080
• Chan, David C. (2006) Mitochondrial Fusion and Fission in Mammals; Annual Review of Cell and Developmental Biology; Vol. 22; 79-99; 10.1146/annurev.cellbio.22.010305.104638
• Choi, Seok-Yong and Huang, Ping, el al. (2006) A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis; Nature Cell Biology; Vol. 8; No. 11; 1255-1262; 10.1038/ncb1487
• Chen, Hsiuchen and Chan, David C. (2006) Critical dependence of neurons on mitochondrial dynamics; Current Opinion in Cell Biology; Vol. 18; No. 4; 453-459; 10.1016/j.ceb.2006.06.004
• Chan, David C. (2006) Mitochondria: Dynamic Organelles in Disease, Aging, and Development; Cell; Vol. 125; No. 7; 1241-1252; 10.1016/j.cell.2006.06.010
• Griffin, Erik E. and Chan, David C. (2006) Domain interactions within Fzo1 oligomers are essential for mitochondrial fusion; Journal of Biological Chemistry; Vol. 281; No. 24; 16599-16606; 10.1074/jbc.M601847200
• Soriano, Franscesc X. and Liesa, Marc, el al. (2006) Evidence for a Mitochondrial Regulatory Pathway Defined by Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α, Estrogen-Related Receptor-α, and Mitofusin 2; Diabetes; Vol. 55; No. 6; 1783-1791; 10.2337/db05-0509
• Griffin, Erik E. and Detmer, Scott A., el al. (2006) Molecular mechanism of mitochondrial membrane fusion; Biochimica et Biophysica Acta; Vol. 1763; No. 5-6; 482-489; 10.1016/j.bbamcr.2006.02.003
• Chan, D. and Frank, S., el al. (2006) Mitochondrial dynamics in cell life and death; Cell Death and Differentiation; Vol. 13; No. 4; 680-684; 10.1038/sj.cdd.4401857
• Chen, Hsiuchen and Chan, David C. (2005) Emerging functions of mammalian mitochondrial fusion and fission; Human Molecular Genetics; Vol. 14; No. 2; R283-R289
• Griffin, Erik E. and Graumann, Johannes, el al. (2005) The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria; Journal of Cell Biology; Vol. 170; No. 2; 237-248; PMCID PMC2171414; 10.1083/jcb.200503148
• Chen, Hsiuchen and Chomyn, Anne, el al. (2005) Disruption of fusion results in mitochondrial heterogeneity and dysfunction; Journal of Biological Chemistry; Vol. 280; No. 28; 26185-26192; 10.1074/jbc.M503062200
• Suntoke, Tara R. and Chan, David C. (2005) The Fusion Activity of HIV-1 gp41 Depends on Interhelical Interactions; Journal of Biological Chemistry; Vol. 280; No. 20; 19852-19857; 10.1074/jbc.M502196200
• Koshiba, Takumi and Detmer, Scott A., el al. (2004) Structural Basis of Mitochondrial Tethering by Mitofusin Complexes; Science; Vol. 305; No. 5685; 858-862; 10.1126/science.1099793
• Chen, Hsiuchen and Chan, David C. (2004) Mitochondrial Dynamics in Mammals; Current Topics in Developmental Biology; Vol. 59; 119-144; 10.1016/S0070-2153(04)59005-1
• Karbowski, Mariusz and Arnoult, Damien, el al. (2004) Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis; Journal of Cell Biology; Vol. 164; No. 4; 493-499; PMCID PMC2172000; 10.1083/jcb.200309082
• Koshiba, Takumi and Chan, David C. (2003) The Prefusogenic Intermediate of HIV-1 gp41 Contains Exposed C-peptide Regions; Journal of Biological Chemistry; Vol. 278; No. 9; 7573-7579; 10.1074/jbc.M211154200
• Chen, Hsiuchen and Detmer, Scott A., el al. (2003) Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development; Journal of Cell Biology; Vol. 160; No. 2; 189-200; PMCID PMC2172648; 10.1083/jcb.200211046
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