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        ],
        "abstract": "<p>This joint Editorial was simultaneously published in other American Chemical Society journals..</p>\n<div class=\"article-section-wrapper js-article-section js-content-section  \">\n<p>We confront the terrible reality that systemic racism and discrimination impacts the daily personal and professional lives of many members of the scientific community and broader society. In the U.S., the brutal killing of George Floyd while in police custody is one of the most recent examples of the centuries of systemic violence suffered by Black Americans. This moment and its aftermath lay bare the legacies of racism and its exclusionary practices.</p>\n</div>\n<div class=\"article-section-wrapper js-article-section js-content-section  \">\n<p>Let us be clear: we, the Editors, Staff, and Governance Members of ACS Publications condemn the tragic deaths of Black people and stand in solidarity with Black members of the science and engineering community. Moreover, ACS condemns racism, discrimination, and harassment in all forms. We will not tolerate practices and viewpoints that exclude or demean&nbsp;<em>any</em>&nbsp;member of our community. Despite these good intentions, we recognize that our community has not done enough to provide an environment for Black chemists to thrive.</p>\n</div>\n<div class=\"article-section-wrapper js-article-section js-content-section  \">\n<p>Rep. Eddie Bernice Johnson, Chairwoman of the U.S. House Committee on Science, Space, and Technology said, &ldquo;So far, we have gotten by with a STEM workforce that does not come close to representing the diversity of our nation. However, if we continue to leave behind so much of our nation&rsquo;s brainpower, we cannot succeed.&rdquo; (<a class=\"link link-ref xref-bibr js-link-ref\">1</a>) Indeed, the U.S. National Science Foundation notes that Blacks and other under-represented minority groups continue to be under-represented in science and engineering education and employment. (<a class=\"link link-ref xref-bibr js-link-ref\">2</a>) What is abundantly clear in this moment is that this lack of representation is a symptom of systemic racism across all levels of education and professional life. We know that supportive words are not enough. We must develop and implement a concrete plan for changing our trajectory.</p>\n</div>\n<div class=\"article-section-wrapper js-article-section js-content-section  \">\n<p>Publications and citations are academic currency, and while we like to think publishing a manuscript is &ldquo;just about the science&rdquo;, we know that is not true for everyone. We have seen the biases (largely through the lens of gender and in Western countries because of the limitations in bibliometric analyses) and applaud our colleagues at the RSC for their massive study that explored these gender barriers in the publishing pipeline (<a class=\"link link-ref xref-bibr js-link-ref\">3</a>) and their recent Inclusion and Diversity Framework. (<a class=\"link link-ref xref-bibr js-link-ref\">4</a>) At the present time, unfortunately, less is known about the effects of race and ethnicity on publishing success. A study published in&nbsp;<em>PeerJ</em>, however, found that unprofessional reviewer comments had a disproportionate effect on authors from under-represented groups. (<a class=\"link link-ref xref-bibr js-link-ref\">5</a>)</p>\n</div>\n<div class=\"article-section-wrapper js-article-section js-content-section  \">\n<p>As the world&rsquo;s leading society publisher, we have a responsibility to aggressively combat bias in all aspects of the publishing process, including systemic under-representation of Blacks in this endeavor (no ACS journal is currently led by a Black Editor-in-Chief). Within ACS Publications, we actively track gender and geographic diversity of editors, advisors, authors, and reviewers, and we anecdotally report on race of editors. Diversity encompasses many more dimensions than these, and we acknowledge that we can do much more than we have. We affirm that diversity and inclusion strengthen the research community and its impact, and we are committed to developing, implementing, tracking, and reporting on our progress to ensure that our editors, advisors, reviewers, and authors are more diverse and that all authors receive the same fair treatment and opportunity to publish in our journals. We acknowledge that we do not have all the answers now, but we seek to hear from and listen to our community on how we can improve our journals to be more diverse and inclusive. As first steps, we commit to the taking the following actions:</p>\n</div>\n<div class=\"article-section-wrapper js-article-section js-content-section  \">\n<ul class=\"bullet\">\n<li>\n<p>Gathering and making public our baseline statistics on diversity within our journals, encompassing our editors, advisors, reviewers, and authors; annually reporting on progress</p>\n</li>\n<li>\n<p>Training new and existing editors to recognize and interrupt bias in peer review</p>\n</li>\n<li>\n<p>Including diversity of journal contributors as an explicit measurement of Editor-in-Chief performance</p>\n</li>\n<li>\n<p>Appointing an ombudsperson to serve as a liaison between Editors and our Community</p>\n</li>\n<li>\n<p>Developing an actionable diversity plan for each ACS journal</p>\n</li>\n</ul>\n</div>\n<div class=\"article-section-wrapper js-article-section js-content-section  \">\n<p>These are only initial plans and the start of a conversation: other ideas are beginning to germinate, and we commit to sharing them with you regularly. We invite you contribute your ideas on how we can do better via our&nbsp;<a class=\"link\" href=\"http://axial.acs.org/2020/06/17/editorial-feedback/\" rel=\"noopener\">Axial website</a>. We are listening carefully.</p>\n</div>\n<div class=\"article-section-wrapper js-article-section js-content-section  \">\n<p>We encourage you to take immediate action in your own circles. In a recent editorial,&nbsp;<em>JACS</em>&nbsp;Associate Editor Melanie Sanford (<a class=\"link link-ref xref-bibr js-link-ref\">6</a>) offered practical steps to take now. Take a moment to find out more about these actions and how to bring them into your work and your life.</p>\n</div>\n<div class=\"article-section-wrapper js-article-section js-content-section  \">\n<p>We all have a responsibility to eradicate racism and discrimination in the science and engineering community; indeed, to make a real difference, we need to be antiracist. The tragic events we have seen in the Black community provide great urgency to this goal. The work will be difficult and will force us to confront hard realities about our beliefs and actions. We fully expect that you, and everyone in the community, will hold us accountable.</p>\n</div>",
        "doi": "10.1021/acsami.0c10979",
        "issn": "1944-8244",
        "publisher": "American Chemical Society",
        "publication": "ACS Applied Materials & Interfaces",
        "publication_date": "2020-07-01",
        "series_number": "26",
        "volume": "12",
        "issue": "26",
        "pages": "28925\u201328927"
    },
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        "type": "article",
        "title": "Update to Our Reader, Reviewer, and Author Communities\u2014April 2020",
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            },
            {
                "family_name": "Proteau",
                "given_name": "Philip",
                "orcid": "0000-0001-7791-8854"
            },
            {
                "family_name": "Yates",
                "given_name": "John R.",
                "orcid": "0000-0001-5267-1672"
            },
            {
                "family_name": "Stang",
                "given_name": "Peter",
                "orcid": "0000-0002-2307-0576"
            },
            {
                "family_name": "Walker",
                "given_name": "Gilbert C.",
                "orcid": "0000-0002-5248-5498"
            },
            {
                "family_name": "Hillmyer",
                "given_name": "Marc",
                "orcid": "0000-0001-8255-3853"
            },
            {
                "family_name": "Taylor",
                "given_name": "Lynne S.",
                "orcid": "0000-0002-4568-6021"
            },
            {
                "family_name": "Odom",
                "given_name": "Teri W.",
                "orcid": "0000-0002-8490-292X"
            },
            {
                "family_name": "Carreira",
                "given_name": "Erick",
                "orcid": "0000-0003-1472-490X",
                "clpid": "Carreira-E-M"
            },
            {
                "family_name": "Rossen",
                "given_name": "Kai",
                "orcid": "0000-0002-3857-0004"
            },
            {
                "family_name": "Chirik",
                "given_name": "Paul",
                "orcid": "0000-0001-8473-2898"
            },
            {
                "family_name": "Miller",
                "given_name": "Scott J.",
                "orcid": "0000-0001-7817-1318"
            },
            {
                "family_name": "McCoy",
                "given_name": "Anne",
                "orcid": "0000-0001-6851-6634"
            },
            {
                "family_name": "Shea",
                "given_name": "Joan-Emma",
                "orcid": "0000-0002-9801-9273"
            },
            {
                "family_name": "Zanni",
                "given_name": "Martin",
                "orcid": "0000-0001-7191-9768"
            },
            {
                "family_name": "Murphy",
                "given_name": "Catherine",
                "orcid": "0000-0001-7066-5575"
            },
            {
                "family_name": "Scholes",
                "given_name": "Gregory",
                "orcid": "0000-0003-3336-7960"
            },
            {
                "family_name": "Loo",
                "given_name": "Joseph A.",
                "orcid": "0000-0001-9989-1437"
            }
        ],
        "abstract": "<div class=\"article-section-wrapper js-article-section js-content-section  \">\n<p>This joint Editorial was simultaneously published in other American Chemical Society journals.</p>\n<p>The research community faces unprecedented disruption from the global COVID-19 pandemic. Some researchers are beginning to return to lab work after a hiatus, but others continue to work as best as they can from home, including ourselves. The global editorial, support, and production staff of ACS journals continue to work as usual, even though most are working from locations that are not their usual work environment.</p>\n</div>\n<div class=\"article-section-wrapper js-article-section js-content-section  \">\n<p>Throughout this period, we seek to assist our authors, reviewers, and readers, despite the exceptional disruption to their normal research workflow. One area of particular concern is that authors may require extra time to prepare revised manuscripts, especially if additional laboratory-based experimental work is required to address specific reviewer or editor concerns. At this time, reviewers may consider limiting their recommendations for additional experimental work, except in those cases where they deem it necessary to support the central claims of the paper and maintain high standards of science/engineering. Please let us know if you require extra time to complete a revision of your manuscript as we are happy to work with you to determine an appropriate course of action. Should authors or reviewers have questions or concerns during this period regarding the need for additional time for a review or revision, please do not hesitate to contact the editorial office responsible for the manuscript and/or the editor-in-chief.</p>\n</div>\n<div class=\"article-section-wrapper js-article-section js-content-section  \">\n<p>ACS Publications has a resource page for readers, authors and reviewers and it can be&nbsp;<a class=\"link\" href=\"https://axial.acs.org/2020/03/25/chemists-covid-19-coronavirus/\" rel=\"noopener\">accessed here</a>.</p>\n</div>\n<div class=\"article-section-wrapper js-article-section js-content-section  \">\n<p>The editors and staff at our journals wish our community the best as it faces multiple challenges arising from the pandemic. Among those most impacted are young scientists and other early career members of the community, and we hope everyone does their best to support one another, especially those most affected by the disruption, and that, globally, we observe a quick resolution to the situation.</p>\n</div>",
        "doi": "10.1021/jacs.0c04253",
        "issn": "0002-7863",
        "publisher": "American Chemical Society",
        "publication": "Journal of the American Chemical Society",
        "publication_date": "2020-05-06",
        "series_number": "18",
        "volume": "142",
        "issue": "18",
        "pages": "8059-8060"
    },
    {
        "id": "authors:18rhm-hcq65",
        "collection": "authors",
        "collection_id": "18rhm-hcq65",
        "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20200302-145210367",
        "type": "article",
        "title": "Molecular Recognition and Cocrystallization of Methylated and Halogenated Fragments of Danicalipin A by Enantiopure Alleno-Acetylenic Cage Receptors",
        "author": [
            {
                "family_name": "Gropp",
                "given_name": "Cornelius",
                "clpid": "Gropp-C"
            },
            {
                "family_name": "Fischer",
                "given_name": "Stefan",
                "orcid": "0000-0003-4110-6576",
                "clpid": "Fischer-S"
            },
            {
                "family_name": "Husch",
                "given_name": "Tamara",
                "orcid": "0000-0002-2880-2481",
                "clpid": "Husch-T"
            },
            {
                "family_name": "Trapp",
                "given_name": "Nils",
                "clpid": "Trapp-N"
            },
            {
                "family_name": "Carreira",
                "given_name": "Erick M.",
                "orcid": "0000-0003-1472-490X",
                "clpid": "Carreira-E-M"
            },
            {
                "family_name": "Diederich",
                "given_name": "Fran\u00e7ois",
                "orcid": "0000-0003-1947-6327",
                "clpid": "Diederich-F"
            }
        ],
        "abstract": "Enantiopure (P)\u2084\u207b and (M)\u2084-configured alleno-acetylenic cage (AAC) receptors offer a highly defined interior for the complexation and structure elucidation of small molecule fragments of the stereochemically complex chlorosulfolipid danicalipin A. Solution (NMR), solid state (X-ray), and theoretical investigations of the formed host\u2013guest complexes provide insight into the conformational preferences of 14 achiral and chiral derivatives of the danicalipin A chlorohydrin core in a confined, mostly hydrophobic environment, extending previously reported studies in polar solvents. The conserved binding mode of the guests permits deciphering the effect of functional group replacements on Gibbs binding energies \u0394G. A strong contribution of conformational energies toward the binding affinities is revealed, which explains why the denser packing of larger apolar domains of the guests does not necessarily lead to higher association. Enantioselective binding of chiral guests, with energetic differences \u0394\u0394G_(293 K) up to 0.7 kcal mol\u207b\u00b9 between diastereoisomeric complexes, is explained by hydrogen- and halogen-bonding, as well as dispersion interactions. Calorimetric studies (ITC) show that the stronger binding of one enantiomer is accompanied by an increased gain in enthalpy \u0394H but at the cost of a larger entropic penalty T\u0394S stemming from tighter binding.",
        "doi": "10.1021/jacs.9b13217",
        "issn": "0002-7863",
        "publisher": "American Chemical Society",
        "publication": "Journal of the American Chemical Society",
        "publication_date": "2020-03-11",
        "series_number": "10",
        "volume": "142",
        "issue": "10",
        "pages": "4749-4755"
    },
    {
        "id": "authors:k0tp1-m1g65",
        "collection": "authors",
        "collection_id": "k0tp1-m1g65",
        "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20190124-111248679",
        "type": "article",
        "title": "Organic Letters 2.0: A New Beginning",
        "author": [
            {
                "family_name": "Carreira",
                "given_name": "Erick M.",
                "orcid": "0000-0003-1472-490X",
                "clpid": "Carreira-E-M"
            },
            {
                "family_name": "Brimble",
                "given_name": "Margaret",
                "clpid": "Brimble-M"
            },
            {
                "family_name": "Chiu",
                "given_name": "Pauline",
                "clpid": "Chiu-Pauline"
            },
            {
                "family_name": "Ding",
                "given_name": "Kuiling",
                "clpid": "Ding-Kuiling"
            },
            {
                "family_name": "Liu",
                "given_name": "Hung-wen",
                "clpid": "Liu-Hung-wen"
            },
            {
                "family_name": "Maulide",
                "given_name": "Nuno",
                "clpid": "Maulide-N"
            },
            {
                "family_name": "Prasad",
                "given_name": "Kavirayani R.",
                "clpid": "Prasad-K-R"
            },
            {
                "family_name": "Reisman",
                "given_name": "Sarah E.",
                "orcid": "0000-0001-8244-9300",
                "clpid": "Reisman-S-E"
            },
            {
                "family_name": "Ritter",
                "given_name": "Tobias",
                "clpid": "Ritter-T"
            },
            {
                "family_name": "Xi",
                "given_name": "Zhenfeng",
                "clpid": "Xi-Zhenfeng"
            },
            {
                "family_name": "Yamaguchi",
                "given_name": "Shigehiro",
                "clpid": "Yamaguchi-Shigehiro"
            },
            {
                "family_name": "Yu",
                "given_name": "Jin-Quan",
                "clpid": "Yu-Jin-Quan"
            }
        ],
        "abstract": "Last year, Organic Letters celebrated its 20-year anniversary. To younger authors and readers, it is hard to appreciate that Organic Letters, as the new kid on the block back then as far as ACS journals go, was trail-blazing in its approach to all aspects of scientific publications\u2014a letters journal that rapidly published top-shelf, rigorously peer-reviewed research. It is hard to believe now that two decades have elapsed since the journal's launch with Professor Amos B. Smith III as the founding Editor-in-Chief. Under Prof. Smith's visionary, steady leadership, Organic Letters quickly skyrocketed to the preeminent position it holds today as the leading organic chemistry journal. Organic Letters has benefitted from a close-knit group of Associate Editors that enjoys the broad respect of the community at large, because they are active scientists engaged in all aspects of research, including publication of high-caliber science. This is reassuring to scientists\u2014authors who entrust their hard work to the rigors of peer review.",
        "doi": "10.1021/acs.orglett.8b03964",
        "issn": "1523-7060",
        "publisher": "American Chemical Society",
        "publication": "Organic Letters",
        "publication_date": "2019-01-04",
        "series_number": "1",
        "volume": "21",
        "issue": "1",
        "pages": "1-4"
    },
    {
        "id": "authors:zd50q-17a48",
        "collection": "authors",
        "collection_id": "zd50q-17a48",
        "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20170411-152927665",
        "type": "article",
        "title": "Enantioselective Synthesis of the Cyclopentyl Core of the Axinellamines",
        "author": [
            {
                "family_name": "Starr",
                "given_name": "Jeremy T.",
                "clpid": "Starr-J-T"
            },
            {
                "family_name": "Koch",
                "given_name": "Guido",
                "clpid": "Koch-G"
            },
            {
                "family_name": "Carreira",
                "given_name": "Erick M.",
                "orcid": "0000-0003-1472-490X",
                "clpid": "Carreira-E-M"
            }
        ],
        "abstract": "Axinellamines A\u2212D (1\u22124) are novel bis-guanidine alkaloids isolated from the marine sponge Axinella sp. of which Axinellamines B\u2212D (2\u22124) have been shown to possess bactericidal activity against Helicobacter pylori, a bacterium implicated in pepticular and gastric cancer.1 These natural products are noteworthy for the structural complexity of the polycyclic framework incorporating fused and spirocyclic ring systems. Moreover, embedded within these structures is a stereochemically complex and densely functionalized cyclopentyl core that presents a daunting synthetic challenge. A similarly substituted cyclopentane core can be found in palau'amine 5 which critically differs from that of 1\u22124 in the relative stereochemical relationships of the pendant functionality.2 Palau'amine 5 has attracted considerable attention due to its potent antibiotic, immunosuppressive, and cytotoxic properties (Chart 1).",
        "doi": "10.1021/ja0019575",
        "issn": "0002-7863",
        "publisher": "American Chemical Society",
        "publication": "Journal of the American Chemical Society",
        "publication_date": "2000-09-13",
        "series_number": "36",
        "volume": "122",
        "issue": "36",
        "pages": "8793-8794"
    },
    {
        "id": "authors:jk3kv-qqc86",
        "collection": "authors",
        "collection_id": "jk3kv-qqc86",
        "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180507-135626223",
        "type": "article",
        "title": "Mechanistic Insights into Cu-Catalyzed Asymmetric Aldol Reactions: Chemical and Spectroscopic Evidence for a Metalloenolate Intermediate",
        "author": [
            {
                "family_name": "Pagenkopf",
                "given_name": "Brian L.",
                "clpid": "Pagenkopf-B-L"
            },
            {
                "family_name": "Kr\u00fcger",
                "given_name": "Jochen",
                "clpid": "Kr\u00fcger-J"
            },
            {
                "family_name": "Stojanovic",
                "given_name": "Aleksandar",
                "clpid": "Stojanovic-A"
            },
            {
                "family_name": "Carreira",
                "given_name": "Erick M.",
                "orcid": "0000-0003-1472-490X",
                "clpid": "Carreira-E-M"
            }
        ],
        "abstract": "In situ IR spectroscopy and transmetalation experiments confirm a postulated catalytic cycle. The metalloenolate 1 describes the active intermediate in the aldol reaction catalyzed by [CuF_2{(S)\u2010tol\u2010binap}] (see reaction scheme). (S)\u2010tol\u2010binap=(S)\u2010(\u2212)\u20102,2\u2032\u2010bis(di\u2010p\u2010tolylphosphanyl)\u20101,1\u2032\u2010binaphthyl.",
        "doi": "10.1002/(SICI)1521-3773(19981204)37:22<3124::AID-ANIE3124>3.0.CO;2-1",
        "issn": "1433-7851",
        "publisher": "Wiley",
        "publication": "Angewandte Chemie International Edition",
        "publication_date": "1998-12-04",
        "series_number": "22",
        "volume": "37",
        "issue": "22",
        "pages": "3124-3126"
    },
    {
        "id": "authors:0vs19-k3b76",
        "collection": "authors",
        "collection_id": "0vs19-k3b76",
        "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180507-142321043",
        "type": "article",
        "title": "Total Synthesis of Macrolactin A with Versatile Catalytic, Enantioselective Dienolate Aldol Addition Reactions",
        "author": [
            {
                "family_name": "Kim",
                "given_name": "Yuntae",
                "clpid": "Kim-Yuntae"
            },
            {
                "family_name": "Singer",
                "given_name": "Robert A.",
                "clpid": "Singer-R-A"
            },
            {
                "family_name": "Carreira",
                "given_name": "Erick M.",
                "orcid": "0000-0003-1472-490X",
                "clpid": "Carreira-E-M"
            }
        ],
        "abstract": "A highly convergent total synthesis of macrolactin A (1) utilizes modern asymmetric catalytic C\u2013C coupling methods. The longest linear sequence in the route is 16 steps with an average yield of 86% per step. This total synthesis is valuable, because 1, which has been shown to possess activity against HIV, is not readily accessible from its natural source, a taxonomically unclassified deep\u2010sea bacterium.",
        "doi": "10.1002/(SICI)1521-3773(19980518)37:9<1261::AID-ANIE1261>3.0.CO;2-2",
        "issn": "1433-7851",
        "publisher": "Wiley",
        "publication": "Angewandte Chemie International Edition",
        "publication_date": "1998-05-18",
        "series_number": "9",
        "volume": "37",
        "issue": "9",
        "pages": "1261-1263"
    },
    {
        "id": "authors:3q36w-9q914",
        "collection": "authors",
        "collection_id": "3q36w-9q914",
        "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180809-152106342",
        "type": "article",
        "title": "The application of nitrido manganese reagents to the synthesis of protected N-methyl D-fucosamine",
        "author": [
            {
                "family_name": "Carreira",
                "given_name": "Erick M.",
                "orcid": "0000-0003-1472-490X",
                "clpid": "Carreira-E-M"
            },
            {
                "family_name": "Hong",
                "given_name": "Jason",
                "clpid": "Hong-Jason"
            },
            {
                "family_name": "Du Bois",
                "given_name": "Justin",
                "orcid": "0000-0001-7847-1548",
                "clpid": "Du-Bois-Justin"
            },
            {
                "family_name": "Tomooka",
                "given_name": "Craig S.",
                "clpid": "Tomooka-C-S"
            }
        ],
        "abstract": "A synthesis of protected D-fucosamine and N-methyl fucosamine from D-galactose is described. The synthesis is carried out in ten steps and includes the amination reaction of D-fucal with an easily prepared Mn\u2261N reagent.",
        "doi": "10.1351/pac199870051097",
        "issn": "0033-4545",
        "publisher": "International Union of Pure and Applied Chemistry",
        "publication": "Pure and Applied Chemistry",
        "publication_date": "1998-05",
        "series_number": "5",
        "volume": "70",
        "issue": "5",
        "pages": "1097-1103"
    },
    {
        "id": "authors:t1n86-m3s82",
        "collection": "authors",
        "collection_id": "t1n86-m3s82",
        "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20171205-095237857",
        "type": "article",
        "title": "Nitridomanganese(V) Complexes: Design, Preparation, and Use as Nitrogen Atom-Transfer Reagents",
        "author": [
            {
                "family_name": "Du Bois",
                "given_name": "J.",
                "orcid": "0000-0001-7847-1548",
                "clpid": "Du-Bois-Justin"
            },
            {
                "family_name": "Tomooka",
                "given_name": "Craig S.",
                "clpid": "Tomooka-C-S"
            },
            {
                "family_name": "Hong",
                "given_name": "Jason",
                "clpid": "Hong-Jason"
            },
            {
                "family_name": "Carreira",
                "given_name": "Erick M.",
                "orcid": "0000-0003-1472-490X",
                "clpid": "Carreira-E-M"
            }
        ],
        "abstract": "Oxidation of organic substrates by direct oxygen-atom\ntransfer from transition-metal complexes is of fundamental\nimportance and has been subject to intensive investigation.\nHighly selective methods for alkene epoxidation\nand dihydroxylation have been described and are commonly\nemployed in synthesis. By contrast, significantly fewer reagents and protocols are available for the analogous\nnitrogen-atom-transfer process, despite the enormous\npotential utility of such methodology. Recent efforts by other groups to develop general olefin amination\nstrategies have led to impressive advances in both metalcatalyzed hydroxyamination and aziridination. Our\ninterest in this area has resulted in the preparation and\ncharacterization of novel nitridomanganese complexes\nwhich may be activated for nitrogen-atom transfer. Pivotal\nto the success of this research has been the development\nof new protocols for the construction of these\nmanganese nitride (Mn\u2261N) reagents. These systems have\nproven to be versatile and effective aminating agents with\ndifferent classes of olefins which include both silyl enol\nethers and glycals (eq 1). The following account documents\nthese findings and highlights the unique chemistry\nof these complexes as nitrogen-atom-transfer reagents.",
        "doi": "10.1021/ar960222v",
        "issn": "0001-4842",
        "publisher": "American Chemical Society",
        "publication": "Accounts of Chemical Research",
        "publication_date": "1997-09",
        "series_number": "9",
        "volume": "30",
        "issue": "9",
        "pages": "364-372"
    },
    {
        "id": "authors:gchqv-j4k40",
        "collection": "authors",
        "collection_id": "gchqv-j4k40",
        "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180601-163441646",
        "type": "article",
        "title": "Catalytic, Enantioselective Aldol Additions with Methyl and Ethyl Acetate O-Silyl Enolates: A Chiral Tridentate Chelate as a Ligand for Titanium(IV)",
        "author": [
            {
                "family_name": "Carreira",
                "given_name": "Erick M.",
                "orcid": "0000-0003-1472-490X",
                "clpid": "Carreira-E-M"
            },
            {
                "family_name": "Singer",
                "given_name": "Robert A.",
                "clpid": "Singer-R-A"
            },
            {
                "family_name": "Lee",
                "given_name": "Wheeseong",
                "clpid": "Lee-Wheeseong"
            }
        ],
        "abstract": "Asymmetric catalysis of the Mukaiyama aldol reaction has been reported with complexes derived from Al, B, Sn(II), and\nTi(IV). The levels of asymmetric induction for the addition of propionate-, isobutyrate-, and acetate-derived silyl thioketene acetals to aldehydes parallel those obtained with chiral-auxiliary-based methodologies. However, silyl ketene acetals derived from O-alkyl acetates uniformly provide aldolates possessing lower levels of asymmetric induction. We have initiated a study aimed at the design and synthesis of chiral Ti(IV) complexes that catalyze the enantioselective Mukaiyama aldol of O-trimethylsilyl, O-methyl, and O-ethyl ketene acetals with aldehydes. We report herein a catalyst that consists of a tridentate ligand derived from 3, Ti(O'^iPr)_4, and 3,5-di-tert-butylsalicylic acid. This catalyst (2-5 mol %) furnishes aldol adducts in good yields and high levels of asymmetric induction (88-97% ee).",
        "doi": "10.1021/ja00098a065",
        "issn": "0002-7863",
        "publisher": "American Chemical Society",
        "publication": "Journal of the American Chemical Society",
        "publication_date": "1994-09-21",
        "series_number": "19",
        "volume": "116",
        "issue": "19",
        "pages": "8837-8838"
    },
    {
        "id": "authors:tm3p1-d7r70",
        "collection": "authors",
        "collection_id": "tm3p1-d7r70",
        "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180601-151522887",
        "type": "article",
        "title": "Asymmetric Induction in Intramolecular [2 + 2]-Photocycloadditions of 1,3-Disubstituted Allenes with Enones and Enoates",
        "author": [
            {
                "family_name": "Carreira",
                "given_name": "Erick M.",
                "orcid": "0000-0003-1472-490X",
                "clpid": "Carreira-E-M"
            },
            {
                "family_name": "Hastings",
                "given_name": "Curtis A.",
                "clpid": "Hastings-C-A"
            },
            {
                "family_name": "Shepard",
                "given_name": "Mary S.",
                "clpid": "Shepard-M-S"
            },
            {
                "family_name": "Yerkey",
                "given_name": "Lori A.",
                "clpid": "Yerkey-L-A"
            },
            {
                "family_name": "Millward",
                "given_name": "Dan B.",
                "clpid": "Millward-D-B"
            }
        ],
        "abstract": "Irradiation of optically active allenes (89-92% ee) appended to enones and enoates affords alkylidenecyclobutane photoadducts with high levels of asymmetric induction (83-100%) derived exclusively from the allene fragment. The substrates studied include allenes tethered to enones such as 1,3-cyclohexanedionea nd 1,3-cyclopentanedione, as well\nas allenes tethered to functionalized coumarins. The enantiomer ratios of the photoadducts were quantified by derivatization of the products as the corresponding Mosher MTPA esters and analysis by ^1H NMR spectroscopy. The exo-methylenecyclobutanes obtained upon irradiation of allene-mumarins are isolated as single olefin diastereomers. Irradiation of a coumarin tethered at C(5) with an optically active allene affords an alkynyl-substituted oxepane with complete asymmetric induction.",
        "doi": "10.1021/ja00094a017",
        "issn": "0002-7863",
        "publisher": "American Chemical Society",
        "publication": "Journal of the American Chemical Society",
        "publication_date": "1994-07-27",
        "series_number": "15",
        "volume": "116",
        "issue": "15",
        "pages": "6622-6630"
    }
]