[
    {
        "id": "authors:4g81b-med79",
        "collection": "authors",
        "collection_id": "4g81b-med79",
        "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20160322-120549369",
        "type": "article",
        "title": "The \u03b1_4 Subunit of Integrin Is Important for Neural Crest Cell Migration",
        "author": [
            {
                "family_name": "Kil",
                "given_name": "Sung H.",
                "clpid": "Kil-Sung-H"
            },
            {
                "family_name": "Krull",
                "given_name": "Catherine E.",
                "clpid": "Krull-C-E"
            },
            {
                "family_name": "Cann",
                "given_name": "Gordon",
                "clpid": "Cann-G-L"
            },
            {
                "family_name": "Clegg",
                "given_name": "Dennis",
                "clpid": "Clegg-D"
            },
            {
                "family_name": "Bronner-Fraser",
                "given_name": "Marianne",
                "orcid": "0000-0003-4274-1862",
                "clpid": "Bronner-M-E"
            }
        ],
        "abstract": "We identify the \u03b1_4 subunit of integrin as a predominant integrin expressed by neural crest cells in both avian and murine embryos. Using degenerate primers, we obtained a PCR fragment of the chick integrin \u03b1_4 subunit that was subsequently used to clone the full-length subunit with a predicted amino acid sequence 60% identical to human and mouse \u03b1_4 subunits.In situhybridization demonstrates that chick integrin \u03b1_4 mRNA is expressed at high levels by migrating neural crest cells and neural crest-derived ganglia at both cranial and trunk levels. An antibody against the murine \u03b1_4 subunit revealed similar distribution patterns in mouse to chick. In addition to neural crest cells, the integrin \u03b1_4 subunit was later observed on the muscle masses of the limb, the apical ectodermal ridge, and the developing liver. To examine the functional role of the integrin \u03b1_4 subunit in neural crest cell migration, we used an explant preparation that allows visualization of neural crest cells in their normal environment with or without perturbing reagents. In the presence of a blocking antibody against the mouse integrin \u03b1_4 subunit, there was a profound abrogation of neural crest cell migration at trunk and hindbrain levels. Both the numbers of migrating neural crest cells and the total distance traversed were markedly reduced. Similarly, avian embryos injected with synthetic peptides that contain the integrin \u03b1_4 binding site in fibronectin displayed abnormal neural crest cell migration. Our results suggest that the integrin \u03b1_4 subunit is important for normal neural crest cell migration and may be one of the primary \u03b1 subunits used for neural crest cell migrationin vivo.Furthermore, the integrin \u03b1_4 subunit represents a useful neural crest marker in the mouse.",
        "doi": "10.1006/dbio.1998.8985",
        "issn": "0012-1606",
        "publisher": "Elsevier",
        "publication": "Developmental Biology",
        "publication_date": "1998-10-01",
        "series_number": "1",
        "volume": "202",
        "issue": "1",
        "pages": "29-42"
    },
    {
        "id": "authors:m1zjb-r2s64",
        "collection": "authors",
        "collection_id": "m1zjb-r2s64",
        "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20120905-074408038",
        "type": "article",
        "title": "Electrical Conductivity of a Partially Ionized Gas",
        "author": [
            {
                "family_name": "Cann",
                "given_name": "Gordon L.",
                "clpid": "Cann-G-L"
            }
        ],
        "abstract": "While investigating the energy transfer processes\noccurring between an electric arc and the surrounding\ngas, it was found desirable to study in detail the\ntransport properties of species diffusion and thermal flux\nin a partially ionized monatomic gas in the presence of a\nmagnetic field.",
        "doi": "10.1063/1.1706143",
        "issn": "1070-6631",
        "publisher": "American Institute of Physics",
        "publication": "Physics of Fluids",
        "publication_date": "1960-11",
        "series_number": "6",
        "volume": "3",
        "issue": "6",
        "pages": "1031-1032"
    }
]