[ { "id": "authors:bjmfg-b1h83", "collection": "authors", "collection_id": "bjmfg-b1h83", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20180727-112821635", "type": "article", "title": "The Constitution of Pirylene: Chemical Evidence", "author": [ { "family_name": "Sargent", "given_name": "Herbert", "clpid": "Sargent-H" }, { "family_name": "Buchman", "given_name": "Edwin R.", "clpid": "Buchman-E-R" }, { "family_name": "Farquhar", "given_name": "John P.", "clpid": "Farquhar-J-P" } ], "abstract": "A sample of this hydrocarbon has been submitted to Dr. V. Schomaker and Dr. R. Spurr of these Laboratories who have been able to work out its structure from the electron diffraction pattern. Their investigation indicates that (IV) is not a ring compound, but possesses the structure (V) of 1-methyl-2-vinylacetylene, a known substance, the physical properties of which agree well with those of pirylene. \n\nThe results of our chemical investigation are in full conformity with this conclusion. On catalytic reduction pirylene readily took up three moles of hydrogen; the reduced product was shown to be n-pentane. It also added one mole of hydrogen chloride, as has been demonstrated for (V), giving 3-chloro-1,3-pentadiene (methylchloroprene) (VI).", "doi": "10.1021/ja01263a046", "issn": "0002-7863", "publisher": "American Chemical Society", "publication": "Journal of the American Chemical Society", "publication_date": "1942-11", "series_number": "11", "volume": "64", "issue": "11", "pages": "2692-2693" }, { "id": "authors:bnkq0-31e77", "collection": "authors", "collection_id": "bnkq0-31e77", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:BUCpnas40", "type": "article", "title": "Inhibition of Carboxylase by Thiazole Pyrophosphate", "author": [ { "family_name": "Buchman", "given_name": "Edwin R.", "clpid": "Buchman-E-R" }, { "family_name": "Heegaard", "given_name": "Erik", "clpid": "Heegaard-E-V" }, { "family_name": "Bonner", "given_name": "James", "clpid": "Bonner-J" } ], "abstract": "In the course of investigations dealing with vitamin B1 (thiamin) analogs, and having as their goal the furtherance of our knowledge of the physiological r\u00f4le of the vitamin, we have observed that a number of substances having a structure similar to that of cocarboxylase (thiamin pyrophosphate [1]), although not themselves able to replace the latter in the enzymatic decarboxylation of pyruvic acid, are able to inhibit markedly the activity of the carboxylase system. The most active inhibitant studied is the pyrophosphoric acid ester of the thiamin thiazole moiety (the thiazole pyrophosphate portion of the cocarboxylase molecule), which will be referred to as \"thiazole pyrophosphate.\"", "issn": "0027-8424", "publisher": "National Academy of Sciences", "publication": "Proceedings of the National Academy of Sciences of the United States of America", "publication_date": "1940-09-01", "series_number": "9", "volume": "26", "issue": "9", "pages": "561-563" }, { "id": "authors:3sznt-zps67", "collection": "authors", "collection_id": "3sznt-zps67", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:BORpnas40", "type": "article", "title": "The Course of Thiamin Metabolism in Man as Indicated by the Use of Radioactive Sulfur", "author": [ { "family_name": "Borsook", "given_name": "Henry", "clpid": "Borsook-H" }, { "family_name": "Buchman", "given_name": "Edwin R.", "clpid": "Buchman-E-R" }, { "family_name": "Hatcher", "given_name": "John B.", "clpid": "Hatcher-J-B" }, { "family_name": "Yost", "given_name": "Don M.", "clpid": "Yost-D-M" }, { "family_name": "McMillan", "given_name": "Edwin", "clpid": "McMillan-E" } ], "abstract": "When supplementary thiamin (Vitamin B1) is ingested or injected, the amount which appears in the urine during the succeeding twenty-four hours usually increases, but the total additional excretion always falls short of the supplement, even when the vitamin is injected and there can be no question of incomplete absorption. We have sought information on this unaccounted-for moiety by synthesizing thiamin from sulfur which contains the radioactive isotope S35 (designated as B1*) and by following, after injection of the B1*, the excretion of the radiosulfur (S*) in the urine and feces and the excretion of total free B1 in the urine.", "issn": "0027-8424", "publisher": "National Academy of Sciences", "publication": "Proceedings of the National Academy of Sciences of the United States of America", "publication_date": "1940-06-01", "series_number": "6", "volume": "26", "issue": "6", "pages": "412-418" }, { "id": "authors:kpp3m-qw566", "collection": "authors", "collection_id": "kpp3m-qw566", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:BONpnas39a", "type": "article", "title": "The synthesis and destruction of vitamin B-1, by Phycomyces", "author": [ { "family_name": "Bonner", "given_name": "James", "clpid": "Bonner-J" }, { "family_name": "Buchman", "given_name": "Edwin R.", "clpid": "Buchman-E-R" } ], "abstract": "In an earlier communication (1) data relative to the in vivo synthesis of vitamin B1, by the isolated pea root have been presented. For a fuller understanding of the physiological economy of the vitamin, some insight also into the modes of disappearance of the substance is indispensable. The accumulated evidence now permits us to present a picture both of in vivo synthesis of the vitamin by Phycomyces Blakesleeanus and of a mechanism by which the vitamin molecule is broken down by the latter organism.", "doi": "10.1073/pnas.25.4.164", "pmcid": "PMC1077737", "issn": "0027-8424", "publisher": "National Academy of Sciences", "publication": "Proceedings of the National Academy of Sciences of the United States of America", "publication_date": "1939-04", "series_number": "4", "volume": "25", "issue": "4", "pages": "164-171" }, { "id": "authors:w9a0y-5a720", "collection": "authors", "collection_id": "w9a0y-5a720", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20150811-101842789", "type": "article", "title": "Syntheses Carried Out in Vivo by Isolated Pea Roots: I", "author": [ { "family_name": "Bonner", "given_name": "James", "clpid": "Bonner-J" }, { "family_name": "Buchman", "given_name": "Edwin R.", "clpid": "Buchman-E-R" } ], "abstract": "There has long been interest in the mechanisms by which chemical reactions take place in vivo, and numerous techniques have been applied to the study of this problem. A precise interpretation of purely analytical results is, however, often difficult or impossible, particularly if the reactions in question have been allowed to take place in the intact organism. It is desired to present in the present paper a few of the results obtained with the aid of a new experimental approach to the problem of physiological syntheses. A single relatively simple organ has been cultivated in vitro under conditions which have been closely controlled both as to external environment and as to nutrient supply, and the metabolism related to a single well defined and readily determinable substance has been investigated.", "pmcid": "PMC1077131", "issn": "0027-8424", "publisher": "National Academy of Sciences", "publication": "Proceedings of the National Academy of Sciences of the United States of America", "publication_date": "1938-10", "series_number": "10", "volume": "24", "issue": "10", "pages": "431-438" } ]