[
    {
        "id": "authors:17vnm-7wt88",
        "collection": "authors",
        "collection_id": "17vnm-7wt88",
        "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20231006-213721063",
        "type": "monograph",
        "title": "Mosaic RBD nanoparticles protect against multiple sarbecovirus challenges in animal models",
        "author": [
            {
                "family_name": "Cohen",
                "given_name": "Alexander A.",
                "orcid": "0000-0002-2818-656X",
                "clpid": "Cohen-Alexander-A"
            },
            {
                "family_name": "van Doremalen",
                "given_name": "Neeltje",
                "orcid": "0000-0003-4368-6359",
                "clpid": "van-Doremalen-Neeltje-A"
            },
            {
                "family_name": "Greaney",
                "given_name": "Allison J.",
                "orcid": "0000-0001-7202-3349",
                "clpid": "Greaney-Alison-J"
            },
            {
                "family_name": "Andersen",
                "given_name": "Hanne",
                "clpid": "Andersen-Hanne"
            },
            {
                "family_name": "Sharma",
                "given_name": "Ankur",
                "clpid": "Sharma-Ankur"
            },
            {
                "family_name": "Starr",
                "given_name": "Tyler N.",
                "orcid": "0000-0001-6713-6904",
                "clpid": "Starr-Tyler-N"
            },
            {
                "family_name": "Keeffe",
                "given_name": "Jennifer R.",
                "orcid": "0000-0002-5317-6398",
                "clpid": "Keeffe-Jennifer-R"
            },
            {
                "family_name": "Fan",
                "given_name": "Chengcheng",
                "orcid": "0000-0003-4213-5758",
                "clpid": "Fan-Chengcheng"
            },
            {
                "family_name": "Schulz",
                "given_name": "Jonathan E.",
                "clpid": "Schulz-Jonathan-E"
            },
            {
                "family_name": "Gnanapragasam",
                "given_name": "Priyanthi N. P.",
                "clpid": "Gnanapragasam-Priyanthi-N-P"
            },
            {
                "family_name": "Kakutani",
                "given_name": "Leesa M.",
                "orcid": "0000-0003-3822-7449",
                "clpid": "Kakutani-Leesa-M"
            },
            {
                "family_name": "West",
                "given_name": "Anthony P., Jr.",
                "orcid": "0000-0003-4213-5184",
                "clpid": "West-Anthony-P-Jr"
            },
            {
                "family_name": "Saturday",
                "given_name": "Greg",
                "orcid": "0000-0002-0803-6177",
                "clpid": "Saturday-Greg"
            },
            {
                "family_name": "Lee",
                "given_name": "Yu E.",
                "orcid": "0000-0001-5989-326X",
                "clpid": "Lee-Yu-Erica"
            },
            {
                "family_name": "Gao",
                "given_name": "Han",
                "clpid": "Gao-Han"
            },
            {
                "family_name": "Jette",
                "given_name": "Claudia A.",
                "orcid": "0000-0002-5085-8027",
                "clpid": "Jette-Claudia-A"
            },
            {
                "family_name": "Lewis",
                "given_name": "Mark G.",
                "orcid": "0000-0001-7852-0135",
                "clpid": "Lewis-Mark-G"
            },
            {
                "family_name": "Tan",
                "given_name": "Tiong K.",
                "orcid": "0000-0001-8746-8308",
                "clpid": "Tan-Tiong-K"
            },
            {
                "family_name": "Townsend",
                "given_name": "Alain R.",
                "orcid": "0000-0002-3702-0107",
                "clpid": "Townsend-Alain-R"
            },
            {
                "family_name": "Bloom",
                "given_name": "Jesse D.",
                "orcid": "0000-0003-1267-3408",
                "clpid": "Bloom-Jesse-D"
            },
            {
                "family_name": "Munster",
                "given_name": "Vincent J.",
                "orcid": "0000-0002-2288-3196",
                "clpid": "Munster-Vincent-J"
            },
            {
                "family_name": "Bjorkman",
                "given_name": "Pamela J.",
                "orcid": "0000-0002-2277-3990",
                "clpid": "Bjorkman-P-J"
            }
        ],
        "abstract": "To combat future SARS-CoV-2 variants and spillovers of SARS-like betacoronaviruses (sarbecoviruses) threatening global health, we designed mosaic nanoparticles presenting randomly-arranged sarbecovirus spike receptor-binding domains (RBDs) to elicit antibodies against conserved/relatively-occluded, rather than variable/immunodominant/exposed, epitopes. We compared immune responses elicited by mosaic-8 (SARS-CoV-2 and seven animal sarbecoviruses) and homotypic (only SARS-CoV-2) RBD-nanoparticles in mice and macaques, observing stronger responses elicited by mosaic-8 to mismatched (not on nanoparticles) strains including SARS-CoV and animal sarbecoviruses. Mosaic-8 immunization showed equivalent neutralization of SARS-CoV-2 variants including Omicron and protected from SARS-CoV-2 and SARS-CoV challenges, whereas homotypic SARS-CoV-2 immunization protected only from SARS-CoV-2 challenge. Epitope mapping demonstrated increased targeting of conserved epitopes after mosaic-8 immunization. Together, these results suggest mosaic-8 RBD-nanoparticles could protect against SARS-CoV-2 variants and future sarbecovirus spillovers.",
        "doi": "10.1101/2022.03.25.485875",
        "pmcid": "PMC8978945",
        "publisher": "bioRxiv",
        "publication_date": "2022-03-29"
    }
]