[ { "id": "thesis:1467", "collection": "thesis", "collection_id": "1467", "cite_using_url": "https://resolver.caltech.edu/CaltechETD:etd-04232003-113543", "primary_object_url": { "basename": "Holloway_bw_1953.pdf", "content": "final", "filesize": 5188004, "license": "other", "mime_type": "application/pdf", "url": "/1467/1/Holloway_bw_1953.pdf", "version": "v2.0.0" }, "type": "thesis", "title": "Heterocaryosis in Neurospora crassa", "author": [ { "family_name": "Holloway", "given_name": "Bruce William", "clpid": "Holloway-Bruce-William" } ], "thesis_advisor": [ { "family_name": "Beadle", "given_name": "George Wells", "clpid": "Beadle-G-W" }, { "family_name": "Emerson", "given_name": "Sterling", "clpid": "Emerson-S" } ], "thesis_committee": [ { "family_name": "Unknown", "given_name": "Unknown" } ], "local_group": [ { "literal": "div_biol" } ], "abstract": "It has been shown that heterocaryon formation between certain biochemical mutants of Neurospora crassa is controlled by a number of genes apart from the biochemical mutant genes concerned. Genetic control of heterocaryosis has been shown for several different combinations of mutants. A detailed investigation of the heterocaryon formed between a mutant requiring pantothenic acid and one requiring lysine has demonstrated four and possibly five genes to be concerned in the process of heterocaryon formation. These genes may not only prevent the formation of a heterocaryon but also modify the type of heterocaryotic growth. The characters so affected are the time at which heterocaryotic growth commences, the ability to maintain heterocaryotic growth and the vigor of the growth. The possible mode of action of such genes has been discussed.", "doi": "10.7907/VRRH-S044", "publication_date": "1953", "thesis_type": "phd", "thesis_year": "1953" }, { "id": "thesis:3070", "collection": "thesis", "collection_id": "3070", "cite_using_url": "https://resolver.caltech.edu/CaltechETD:etd-08092006-104758", "primary_object_url": { "basename": "Siegel_a_1951.pdf", "content": "final", "filesize": 22187962, "license": "other", "mime_type": "application/pdf", "url": "/3070/1/Siegel_a_1951.pdf", "version": "v2.0.0" }, "type": "thesis", "title": "I. Irradiation Experiments with Neurospora crassa. II. An Electrophoretic Comparison of the Soluble Proteins of Normal and Virus-Infected Escherichia coli", "author": [ { "family_name": "Siegel", "given_name": "Albert", "clpid": "Siegel-Albert" } ], "thesis_advisor": [ { "family_name": "Beadle", "given_name": "George Wells", "clpid": "Beadle-G-W" } ], "thesis_committee": [ { "family_name": "Unknown", "given_name": "Unknown" } ], "local_group": [ { "literal": "div_biol" } ], "abstract": "Part I: \r\n\r\n1. A case is described and discussed in which a mutant strain of Neurospora which spontaneously reverts to wild type cannot be induced to revert by mutagenic agents.\r\n\r\n2. The action of ultraviolet light on macroconidia of Neurospora is described.\r\n\r\n3. The effect of heat and light post-treatment of ultra-violet irradiated macroconidia has been studied.\r\n\r\n4. Data have been obtained which suggest that the killing effect of UV is more easily reversed by heat or light post-treatment than the mutagenic effect.\r\n\r\nPart II: \r\n\r\n1. The soluble proteins of Escherichia coli were extracted by disrupting the bacteria in a colloid mill and centrifuging all particulate matter out of solution.\r\n\r\n2. The soluble proteins so obtained, were resolved by electrophoresis.\r\n\r\n3. A comparison was made of the electrophoretic scanning patterns of the soluble proteins of non-infected bacteria, bacteria infected with bacteriophage T2 during the \"eclipse\" stage of infection, and bacteria infected for longer than the \"eclipse\" with, the following findings:\r\n\r\na) The amount of free-moving desoxyribonucleic acid (DNA) present in the extracts of uninfected bacteria decreases during the \"eclipse\" stage of infection.\r\n\r\nb) The amount of free-moving DNA increases strikingly after the end of the \"eclipse.\"\r\n\r\n4. Bacteriophage particles were disrupted in the colloid mill. The increase in free moving DNA in the extracts of bacteria infected for longer than the \"eclipse\" was found to be due to disruption of intracellular bacteriophage particles.\r\n\r\n5. DNA was extracted both from bacteriophage particles and from Escherichia coli. A comparison of the two DIVAS by electrophoretical and ultracentrifugal methods reveals a close similarity between them.\r\n\r\n6. The experimental findings are discussed and several suggestions are made for further elucidating the course of virus multiplication.", "doi": "10.7907/MAKD-DR63", "publication_date": "1951", "thesis_type": "phd", "thesis_year": "1951" }, { "id": "thesis:17126", "collection": "thesis", "collection_id": "17126", "cite_using_url": "https://resolver.caltech.edu/CaltechTHESIS:04012025-202225347", "primary_object_url": { "basename": "Teas_HJ_1947.pdf", "content": "final", "filesize": 21287807, "license": "other", "mime_type": "application/pdf", "url": "/17126/1/Teas_HJ_1947.pdf", "version": "v2.0.0" }, "type": "thesis", "title": "The Biochemistry and Genetics of Threonine-Requiring Mutants of Neurospora crassa", "author": [ { "family_name": "Teas", "given_name": "Howard Jones", "clpid": "Teas-Howard-Jones" } ], "thesis_advisor": [ { "family_name": "Beadle", "given_name": "George Wells", "clpid": "Beadle-G-W" }, { "family_name": "Horowitz", "given_name": "Norman Harold", "clpid": "Horowitz-N-H" } ], "thesis_committee": [ { "family_name": "Unknown", "given_name": "Unknown" } ], "local_group": [ { "literal": "div_biol" } ], "abstract": "No abstract.", "doi": "10.7907/5jev-5168", "publication_date": "1947", "thesis_type": "phd", "thesis_year": "1947" }, { "id": "thesis:17174", "collection": "thesis", "collection_id": "17174", "cite_using_url": "https://resolver.caltech.edu/CaltechTHESIS:04252025-202844428", "primary_object_url": { "basename": "Regnery_DC_1947.pdf", "content": "final", "filesize": 39003224, "license": "other", "mime_type": "application/pdf", "url": "/17174/1/Regnery_DC_1947.pdf", "version": "v2.0.0" }, "type": "thesis", "title": "A Study of the Leucineless Mutants of Neurospora crassa", "author": [ { "family_name": "Regnery", "given_name": "David Cook", "clpid": "Regnery-David-Cook" } ], "thesis_advisor": [ { "family_name": "Beadle", "given_name": "George Wells", "clpid": "Beadle-G-W" } ], "thesis_committee": [ { "family_name": "Unknown", "given_name": "Unknown" } ], "local_group": [ { "literal": "div_biol" } ], "abstract": "No abstract.", "doi": "10.7907/kt75-xm57", "publication_date": "1947", "thesis_type": "phd", "thesis_year": "1947" } ]