[ { "id": "authors:ys75z-0ky71", "collection": "authors", "collection_id": "ys75z-0ky71", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20141125-132714294", "type": "article", "title": "Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage", "author": [ { "family_name": "Verdi", "given_name": "Joseph M.", "clpid": "Verdi-J-M" }, { "family_name": "Bashirullah", "given_name": "Arash", "clpid": "Bashirullah-A" }, { "family_name": "Goldhawk", "given_name": "Donna E.", "clpid": "Goldhawk-D-E" }, { "family_name": "Kubu", "given_name": "Chris J.", "clpid": "Kubu-C-J" }, { "family_name": "Jamali", "given_name": "Mina", "clpid": "Jamali-M" }, { "family_name": "Meakin", "given_name": "Susan O.", "clpid": "Meakin-S-O" }, { "family_name": "Lipshitz", "given_name": "Howard D.", "clpid": "Lipshitz-H-D" } ], "abstract": "Neuronal cell fate decisions are directed in Drosophila by NUMB, a signaling adapter protein with two protein\u2013protein interaction domains: a phosphotyrosine-binding domain and a proline-rich region (PRR) that functions as an SH3-binding domain. Here we show that there are at least four human NUMB isoforms and that these serve two distinct developmental functions in the neuronal lineage: differentiation (but not proliferation) is promoted by human NUMB protein isoforms with a type I (short) PRR. In contrast, proliferation (but not differentiation) is directed by isoforms that have a type II (long) PRR. The two types of PRR may promote distinct intracellular signaling pathways downstream of the NOTCH receptor during mammalian neurogenesis.", "doi": "10.1073/pnas.96.18.10472", "pmcid": "PMC17913", "issn": "0027-8424", "publisher": "National Academy of Sciences", "publication": "Proceedings of the National Academy of Sciences of the United States of America", "publication_date": "1999-08-31", "series_number": "18", "volume": "96", "issue": "18", "pages": "10472-10476" }, { "id": "authors:m5gwc-vef75", "collection": "authors", "collection_id": "m5gwc-vef75", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:BASarb98", "type": "article", "title": "RNA localization in development", "author": [ { "family_name": "Bashirullah", "given_name": "Arash", "clpid": "Bashirullah-A" }, { "family_name": "Cooperstock", "given_name": "Ramona L.", "clpid": "Cooperstock-R-L" }, { "family_name": "Lipshitz", "given_name": "Howard D.", "clpid": "Lipshitz-H-D" } ], "abstract": "Cytoplasmic RNA localization is an evolutionarily ancient mechanism for producing cellular asymmetries. This review considers RNA localization in the context of animal development. Both mRNAs and non-protein-coding RNAs are localized in Drosophila, Xenopus, ascidian, zebrafish, and echinoderm oocytes and embryos, as well as in a variety of developing and differentiated polarized cells from yeast to mammals. Mechanisms used to transport and anchor RNAs in the cytoplasm include vectorial transport out of the nucleus, directed cytoplasmic transport in association with the cytoskeleton, and local entrapment at particular cytoplasmic sites. The majority of localized RNAs are targeted to particular cytoplasmic regions by cis-acting RNA elements; in mRNAs these are almost always in the 3'-untranslated region (UTR). A variety of trans-acting factors\u2014many of them RNA-binding proteins\u2014function in localization. Developmental functions of RNA localization have been defined in Xenopus, Drosophila, and Saccharomyces cerevisiae. In Drosophila, localized RNAs program the antero-posterior and dorso-ventral axes of the oocyte and embryo. In Xenopus, localized RNAs may function in mesoderm induction as well as in dorso-ventral axis specification. Localized RNAs also program asymmetric cell fates during Drosophila neurogenesis and yeast budding.", "doi": "10.1146/annurev.biochem.67.1.335", "issn": "0066-4154", "publisher": "Annual Reviews", "publication": "Annual Review of Biochemistry", "publication_date": "1998-07", "volume": "67", "pages": "335-394" }, { "id": "authors:n32za-v3d55", "collection": "authors", "collection_id": "n32za-v3d55", "cite_using_url": "https://resolver.caltech.edu/CaltechAUTHORS:20150623-142635905", "type": "article", "title": "Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila", "author": [ { "family_name": "Cohen", "given_name": "Brenda", "clpid": "Cohen-B" }, { "family_name": "Bashirullah", "given_name": "Arash", "clpid": "Bashirullah-A" }, { "family_name": "Dagnino", "given_name": "Lina", "clpid": "Dagnino-L" }, { "family_name": "Campbell", "given_name": "Christine", "clpid": "Campbell-C" }, { "family_name": "Fisher", "given_name": "William W.", "clpid": "Fisher-W-W" }, { "family_name": "Leow", "given_name": "Ching Ching", "clpid": "Leow-Ching-Ching" }, { "family_name": "Whiting", "given_name": "Elisabeth", "clpid": "Whiting-E" }, { "family_name": "Ryan", "given_name": "David", "clpid": "Ryan-D" }, { "family_name": "Zinyk", "given_name": "Dawn", "clpid": "Zynik-D-L" }, { "family_name": "Boulianne", "given_name": "Gabrielle", "clpid": "Boulianne-G" }, { "family_name": "Hui", "given_name": "Chi-chung", "clpid": "Hui-Chi-chung" }, { "family_name": "Gallie", "given_name": "Brenda", "clpid": "Gallie-B" }, { "family_name": "Phillips", "given_name": "Robert A.", "clpid": "Phillips-R-A" }, { "family_name": "Lipshitz", "given_name": "Howard D.", "clpid": "Lipshitz-H-D" }, { "family_name": "Egan", "given_name": "Sean E.", "clpid": "Egan-S-E" } ], "abstract": "In both vertebrate and invertebrate development, cells are often programmed to adopt fates distinct from their neighbors. Genetic analyses in Drosophila melanogaster have highlighted the importance of cell surface and secreted proteins in these cell fate decisions. Homologues of these proteins have been identified and shown to play similar roles in vertebrate development. Fringe, a novel signalling protein, has been shown to induce wing margin formation in Drosophila. Fringe shares significant sequence homology and predicted secondary structure similarity with bacterial glycosyltransferases. Thus, fringe may control wing development by altering glycosylation of cell surface and/or secreted molecules. Recently, two fringe genes were isolated from Xenopus laevis. We report here the cloning and characterization of three murine fringe genes (lunatic fringe, manic fringe and radical fringe). We find in several tissues that fringe expression boundaries coincide with Notch-dependent patterning centres and with Notch-ligand expression boundaries. Ectopic expression of murine manic fringe or radical fringe in Drosophila results in phenotypes that resemble those seen in Notch mutants.", "doi": "10.1038/ng0797-283", "issn": "1061-4036", "publisher": "Nature Publishing Group", "publication": "Nature Genetics", "publication_date": "1997-07", "series_number": "3", "volume": "16", "issue": "3", "pages": "283-288" } ]