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Lewis, Jared C.; Mantovani, Simone M. et al. (2010) Combinatorial Alanine Substitution Enables Rapid Optimization of Cytochrome P450_(BM3) for Selective Hydroxylation of Large Substrates ChemBioChem; Vol. 11; No. 18;

Farrow, Mary F.; Arnold, Frances H. (2010) Combinatorial Recombination of Gene Fragments to Construct a Library of Chimeras Current Protocols in Protein Science; Vol. 62; No. 1;

Heinzelman, Pete; Komor, Russell et al. (2010) Efficient screening of fungal cellobiohydrolase class I enzymes for thermostabilizing sequence blocks by SCHEMA structure-guided recombination Protein Engineering, Design and Selection; Vol. 23; No. 11;

Acar, Murat; Pando, Bernardo F. et al. (2010) A General Mechanism for Network-Dosage Compensation in Gene Circuits Science; Vol. 329; No. 5999;

Jäckel, Christian; Bloom, Jesse D. et al. (2010) Consensus Protein Design without Phylogenetic Bias Journal of Molecular Biology; Vol. 399; No. 4;

Shapiro, Mikhail G.; Westmeyer, Gil G. et al. (2010) Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine Nature Biotechnology; Vol. 28; No. 3;

Romero, Philip A.; Arnold, Frances H. (2009) Exploring protein fitness landscapes by directed evolution Nature Reviews. Molecular Cell Biology; Vol. 10; No. 12;

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Lewis, Jared C.; Bastian, Sabine et al. (2009) Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450_(BM3) demethylases Proceedings of the National Academy of Sciences of the United States of America; Vol. 106; No. 39;

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Dougherty, Michael J.; Arnold, Frances H. (2009) Directed evolution: new parts and optimized function Current Opinion in Biotechnology; Vol. 20; No. 4;

Bloom, Jesse D.; Arnold, Frances H. (2009) In the light of directed evolution: Pathways of adaptive protein evolution Proceedings of the National Academy of Sciences of the United States of America; Vol. 106; No. Supple; Arthur M. Sackler Colloquium of the National Academy of Sciences, “In the Light of Evolution III: Two Centuries of Darwin”, 16-17 January 2009 , Irvine, CA

Lewis, Jared C.; Arnold, Frances H. (2009) Catalysts on Demand: Selective Oxidations by Laboratory-Evolved Cytochrome P450 BM3 Chimia; Vol. 63; No. 6;

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Tracewell, Cara A.; Arnold, Frances H. (2009) Directed enzyme evolution: climbing fitness peaks one amino acid at a time Current Opinion in Chemical Biology; Vol. 13; No. 1;

Rentmeister, Andrea; Arnold, Frances H. et al. (2009) Chemo-enzymatic fluorination of unactivated organic compounds Nature Chemical Biology; Vol. 5; No. 1;

Koch, Daniel J.; Chen, Mike M. et al. (2009) In Vivo Evolution of Butane Oxidation by Terminal Alkane Hydroxylases AlkB and CYP153A6 Applied and Environmental Microbiology; Vol. 75; No. 2;

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Balagaddé, Frederick K.; Song, Hao et al. (2008) A synthetic Escherichia coli predator–prey ecosystem Molecular Systems Biology; Vol. 4;

Haseltine, Eric L.; Arnold, Frances H. (2008) Implications of Rewiring Bacterial Quorum Sensing Applied and Environmental Microbiology; Vol. 74; No. 2;

Fasan, Rudi; Chen, Mike M. et al. (2007) Engineered Alkane‐Hydroxylating Cytochrome P450_(BM3) Exhibiting Nativelike Catalytic Properties Angewandte Chemie International Edition; Vol. 46; No. 44;

Brenner, Katie; Karig, David K. et al. (2007) Engineered bidirectional communication mediates a consensus in a microbial biofilm consortium Proceedings of the National Academy of Sciences of the United States of America; Vol. 104; No. 44;

Li, Yougen; Drummond, D. Allan et al. (2007) A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments Nature Biotechnology; Vol. 25; No. 9;

Hawkins, Andrew C.; Arnold, Frances H. et al. (2007) Directed evolution of Vibrio fischeri LuxR for improved response to butanoyl-homoserine lactone Applied and Environmental Microbiology; Vol. 73; No. 18;

Carbone, Martina N.; Arnold, Frances H. (2007) Engineering by homologous recombination: exploring sequence and function within a conserved fold Current Opinion in Structural Biology; Vol. 17; No. 4;

Bloom, Jesse D.; Lu, Zhongyi et al. (2007) Evolution favors protein mutational robustness in sufficiently large populations BMC Biology; Vol. 5; No. 29;

Bloom, Jesse D.; Romero, Philip A. et al. (2007) Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution Biology Direct; Vol. 2;

Haseltine, Eric L.; Arnold, Frances H. (2007) Synthetic Gene Circuits: Design with Directed Evolution Annual Review of Biophysics and Biomolecular Structure; Vol. 36;

Landwehr, Marco; Carbone, Martina et al. (2007) Diversification of Catalytic Function in a Synthetic Family of Chimeric Cytochrome P450s Chemistry and Biology; Vol. 14; No. 3;

Bloom, Jesse D.; Arnold, Frances H. et al. (2007) Breaking proteins with mutations: threads and thresholds in evolution Molecular Systems Biology; Vol. 3; No. 1;

Meyer, Michelle M.; Hochrein, Lisa et al. (2006) Structure-guided SCHEMA recombination of distantly related β-lactamase Protein Engineering, Design and Selection; Vol. 19; No. 12;

Bloom, Jesse D.; Drummond, D. Allan et al. (2006) Structural Determinants of the Rate of Protein Evolution in Yeast Molecular Biology and Evolution; Vol. 23; No. 9;

Collins, Cynthia H.; Leadbetter, Jared R. et al. (2006) Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR Nature Biotechnology; Vol. 24; No. 6;

Landwehr, Marco; Hochrein, Lisa et al. (2006) Enantioselective α-Hydroxylation of 2-Arylacetic Acid Derivatives and Buspirone Catalyzed by Engineered Cytochrome P450 BM-3 Journal of the American Chemical Society; Vol. 128; No. 18;

Otey, Christopher R.; Landwehr, Marco et al. (2006) Structure-Guided Recombination Creates an Artificial Family of Cytochromes P450 PLoS Biology; Vol. 4; No. 5;

Bloom, Jesse D.; Labthavikul, Sy T. et al. (2006) Protein stability promotes evolvability Proceedings of the National Academy of Sciences of the United States of America; Vol. 103; No. 15;

Arnold, Frances H. (2006) Fancy footwork in the sequence space shuffle Nature Biotechnology; Vol. 24; No. 3;

Udit, Andrew K.; Hill, Michael G. et al. (2006) Pyrene-Wired Heme Domain Cytochrome P450 BM3 Electrodes ECS Meeting Abstracts; Vol. 501; No. 1;

Otey, Christopher R.; Bandara, Geethani et al. (2006) Preparation of human metabolites of propranolol using laboratory‐evolved bacterial cytochromes P450 Biotechnology and Bioengineering; Vol. 93; No. 3;

Tobias, Alexander V.; Arnold, Frances H. (2006) Biosynthesis of novel carotenoid families based on unnatural carbon backbones: A model for diversification of natural product pathways Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids; Vol. 1761; No. 2;

Kubo, Takafumi; Peters, Matthew W. et al. (2006) Enantioselective Epoxidation of Terminal Alkenes to (R)- and (S)-Epoxides by Engineered Cytochromes P450 BM-3 Chemistry: a European Journal; Vol. 12; No. 4;

Meinhold, Peter; Peters, Matthew W. et al. (2005) Direct Conversion of Ethane to Ethanol by Engineered Cytochrome P450 BM3 ChemBioChem; Vol. 6; No. 10;

Drummond, D. Allan; Bloom, Jesse D. et al. (2005) Why highly expressed proteins evolve slowly Proceedings of the National Academy of Sciences of the United States of America; Vol. 102; No. 40;

Yokobayashi, Yohei; Arnold, Frances H. (2005) A Dual Selection Module for Directed Evolution of Genetic Circuits Natural Computing; Vol. 4; No. 3;

Bloom, Jesse D.; Meyer, Michelle M. et al. (2005) Evolving strategies for enzyme engineering Current Opinion in Structural Biology; Vol. 15; No. 4;

Drummond, D. Allan; Iverson, Brent L. et al. (2005) Why High-error-rate Random Mutagenesis Libraries are Enriched in Functional and Improved Proteins Journal of Molecular Biology; Vol. 350; No. 4;

Balagaddé, Frederick K.; You, Lingchong et al. (2005) Long-Term Monitoring of Bacteria Undergoing Programmed Population Control in a Microchemostat Science; Vol. 309; No. 5731;

Udit, Andrew K.; Hindoyan, Nareen et al. (2005) Protein−Surfactant Film Voltammetry of Wild-Type and Mutant Cytochrome P450 BM3 Inorganic Chemistry; Vol. 44; No. 12;

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Drummond, D. Allan; Silberg, Jonathan J. et al. (2005) On the conservative nature of intragenic recombination Proceedings of the National Academy of Sciences of the United States of America; Vol. 102; No. 15;

Münzer, Dieter F.; Meinhold, Peter et al. (2005) Stereoselective hydroxylation of an achiral cyclopentanecarboxylic acid derivative using engineered P450s BM-3 Chemical Communications; Vol. 2005; No. 20;

Umeno, Daisuke; Tobias, Alexander V. et al. (2005) Diversifying Carotenoid Biosynthetic Pathways by Directed Evolution Microbiology and Molecular Biology Reviews; Vol. 69; No. 1;

Collins, Cynthia H.; Arnold, Frances H. et al. (2005) Directed evolution of Vibrio fischeri LuxR for increased sensitivity to a broad spectrum of acyl-homoserine lactones Molecular Microbiology; Vol. 55; No. 3;

Bloom, Jesse D.; Silberg, Jonathan J. et al. (2005) Thermodynamic prediction of protein neutrality Proceedings of the National Academy of Sciences of the United States of America; Vol. 102; No. 3;

Malliaros, Jim; Quinn, Charles et al. (2004) Association of antigens to ISCOMATRIX™ adjuvant using metal chelation leads to improved CTL responses Vaccine; Vol. 22; No. 29-30;

Udit, Andrew K.; Arnold, Frances H. et al. (2004) Cobaltocene-mediated catalytic monooxygenation using holo and heme domain cytochrome P450 BM3 Journal of Inorganic Biochemistry; Vol. 98; No. 9;

Udit, Andrew K.; Hill, Michael G. et al. (2004) Reduction of Dioxygen Catalyzed by Pyrene-Wired Heme Domain Cytochrome P450 BM3 Electrodes Journal of the American Chemical Society; Vol. 126; No. 33;

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Bloom, Jesse D.; Wilke, Claus O. et al. (2004) Stability and the Evolvability of Function in a Model Protein Biophysical Journal; Vol. 86; No. 5;

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Alcalde, Miguel; Farinas, Edgardo T. et al. (2004) Colorimetric High-Throughput Assay for Alkene Epoxidation Catalyzed by Cytochrome P450 BM-3 Variant 139-3 Journal of Biomolecular Screening; Vol. 9; No. 2;

Umeno, Daisuke; Arnold, Frances H. (2004) Evolution of a Pathway to Novel Long-Chain Carotenoids Journal of Bacteriology; Vol. 186; No. 5;

Otey, Christopher R.; Silberg, Jonathan J. et al. (2004) Functional Evolution and Structural Conservation in Chimeric Cytochromes P450: Calibrating a Structure-Guided Approach Chemistry and Biology; Vol. 11; No. 3;

Wong, Tuck Seng; Arnold, Frances H. et al. (2004) Laboratory evolution of cytochrome P450 BM-3 monooxygenase for organic cosolvents Biotechnology and Bioengineering; Vol. 85; No. 3;

Peters, Matthew W.; Meinhold, Peter et al. (2003) Regio- and Enantioselective Alkane Hydroxylation with Engineered Cytochromes P450 BM-3 Journal of the American Chemical Society; Vol. 125; No. 44;

Cirino, Patrick C.; Tang, Yi et al. (2003) Global incorporation of norleucine in place of methionine in cytochrome P450 BM-3 heme domain increases peroxygenase activity Biotechnology and Bioengineering; Vol. 83; No. 6;

Salazar, Oriana; Cirino, Patrick C. et al. (2003) Thermostabilization of a Cytochrome P450 Peroxygenase ChemBioChem; Vol. 4; No. 9;

Umeno, Daisuke; Hiraga, Kaori et al. (2003) Method to protect a targeted amino acid residue during random mutagenesis Nucleic Acids Research; Vol. 31; No. 16;

Collins, Cynthia H.; Yokobayashi, Yohei et al. (2003) Engineering proteins that bind, move, make and break DNA Current Opinion in Biotechnology; Vol. 14; No. 4;

Meyer, Michelle M.; Silberg, Jonathan J. et al. (2003) Library analysis of SCHEMA-guided protein recombination Protein Science; Vol. 12; No. 8;

Cirino, Patrick C.; Arnold, Frances H. (2003) A Self-Sufficient Peroxide-Driven Hydroxylation Biocatalyst Angewandte Chemie International Edition; Vol. 42; No. 28;

Hiraga, Kaori; Arnold, Frances H. (2003) General Method for Sequence-independent Site-directed Chimeragenesis Journal of Molecular Biology; Vol. 330; No. 2;

Umeno, Daisuke; Arnold, Frances H. (2003) A C35 Carotenoid Biosynthetic Pathway Applied and Environmental Microbiology; Vol. 69; No. 6;

Wintrode, Patrick L.; Zhang, Deqiang et al. (2003) Protein Dynamics in a Family of Laboratory Evolved Thermophilic Enzymes Journal of Molecular Biology; Vol. 327; No. 3;

Yokobayashi, Yohei; Collins, Cynthia H. et al. (2003) Evolutionary Design Of Genetic Circuits And Cell-Cell Communications Advances in Complex Systems; Vol. 6; No. 1; International Conference on Emergence in Chemical Systems, 20-23 June 2002 , Anchorage, AK

Bulter, Thomas; Alcalde, Miguel et al. (2003) Functional Expression of a Fungal Laccase in Saccharomyces cerevisiae by Directed Evolution Applied and Environmental Microbiology; Vol. 69; No. 2;

Yokobayashi, Yohei; Weiss, Ron et al. (2002) Directed evolution of a genetic circuit Proceedings of the National Academy of Sciences of the United States of America; Vol. 99; No. 26;

Alcalde, Miguel; Bulter, Thomas et al. (2002) Colorimetric Assays for Biodegradation of Polycyclic Aromatic Hydrocarbons by Fungal Laccases Journal of Biomolecular Screening; Vol. 7; No. 6;

Umeno, Daisuke; Tobias, Alexander V. et al. (2002) Evolution of the C30 Carotenoid Synthase CrtM for Function in a C40 Pathway Journal of Bacteriology; Vol. 184; No. 23;

Glieder, Anton; Farinas, Edgardo T. et al. (2002) Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase Nature Biotechnology; Vol. 20; No. 11;

Cirino, Patrick C.; Arnold, Frances H. (2002) Regioselectivity and Activity of Cytochrome P450 BM-3 and Mutant F87A in Reactions Driven by Hydrogen Peroxide Advanced Synthesis and Catalysis; Vol. 344; No. 9;

Sun, Lianhong; Bulter, Thomas et al. (2002) Modification of Galactose Oxidase to Introduce Glucose 6-Oxidase Activity ChemBioChem; Vol. 3; No. 8;

Voigt, Christopher A.; Martinez, Carlos et al. (2002) Protein building blocks preserved by recombination Nature Structural Biology; Vol. 9; No. 7;

Fu, Anne Y.; Chou, Hou-Pu et al. (2002) An Integrated Microfabricated Cell Sorter Analytical Chemistry; Vol. 74; No. 11;

Mayer, Kimberly M.; Arnold, Frances H. (2002) A Colorimetric Assay to Quantify Dehydrogenase Activity in Crude Cell Lysates Journal of Biomolecular Screening; Vol. 7; No. 2;

Cirino, Patrick C.; Arnold, Frances H. (2002) Protein engineering of oxygenases for biocatalysis Current Opinion in Chemical Biology; Vol. 6; No. 2;

Joern, John M; Meinhold, Peter et al. (2002) Analysis of shuffled gene libraries Journal of Molecular Biology; Vol. 316; No. 3;

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Sun, Lianhong; Petrounia, Ioanna P. et al. (2001) Expression and stabilization of galactose oxidase in Escherichia coli by directed evolution Protein Engineering; Vol. 14; No. 9;

Morawski, Birgit; Quan, Sara et al. (2001) Functional expression and stabilization of horseradish peroxidase by directed evolution in Saccharomyces cerevisiae Biotechnology and Bioengineering; Vol. 76; No. 2;

Sakamoto, Takeshi; Joern, John M. et al. (2001) Laboratory Evolution of Toluene Dioxygenase To Accept 4-Picoline as a Substrate Applied and Environmental Microbiology; Vol. 67; No. 9;

Joern, John M.; Sakamoto, Takeshi et al. (2001) A Versatile High Throughput Screen for Dioxygenase Activity Using Solid-Phase Digital Imaging Journal of Biomolecular Screening; Vol. 6; No. 4;

Farinas, Edgardo T.; Schwaneberg, Ulrich et al. (2001) Directed Evolution of a Cytochrome P450 Monooxygenase for Alkane Oxidation Advanced Synthesis and Catalysis; Vol. 343; No. 6-7;

Sieber, Volker; Martinez, Carlos A. et al. (2001) Libraries of hybrid proteins from distantly related sequences Nature Biotechnology; Vol. 19; No. 5;

Thorsen, Todd; Roberts, Richard W. et al. (2001) Dynamic Pattern Formation in a Vesicle-Generating Microfluidic Device Physical Review Letters; Vol. 86; No. 18;

Schwaneberg, Ulrich; Otey, Christopher et al. (2001) Cost-Effective Whole-Cell Assay for Laboratory Evolution of Hydroxylases in Escherichia coli Journal of Biomolecular Screening; Vol. 6; No. 2;

Voigt, Christopher A.; Mayo, Stephen L. et al. (2001) Computational method to reduce the search space for directed protein evolution Proceedings of the National Academy of Sciences of the United States of America; Vol. 98; No. 7;

Arnold, Frances H. (2001) Combinatorial and computational challenges for biocatalyst design Nature; Vol. 409; No. 6817;

Voigt, Christopher A.; Mayo, Stephen L. et al. (2001) Computationally Focusing the Directed Evolution of Proteins Journal of Cellular Biochemistry; Vol. 84; No. S37; 5th Annual Lake Tahoe Symposium Location, Jan 29-Feb 02, 2001 , Los Angeles, CA

Wintrode, Patrick L.; Miyazaki, Kentaro et al. (2000) Cold Adaptation of a Mesophilic Subtilisin-like Protease by Laboratory Evolution Journal of Biological Chemistry; Vol. 275; No. 41;

Petrounia, Ioanna P.; Arnold, Frances H. (2000) Designed evolution of enzymatic properties Current Opinion in Biotechnology; Vol. 11; No. 4;

Schmidt-Dannert, Claudia; Umeno, Daisuke et al. (2000) Molecular breeding of carotenoid biosynthetic pathways Nature Biotechnology; Vol. 18; No. 7;

Morawski, Birgit; Lin, Zhanglin et al. (2000) Functional expression of horseradish peroxidase in Saccharomyces cerevisiae and Pichia pastoris Protein Engineering; Vol. 13; No. 5;

Gershenson, Anne; Schauerte, Joseph A. et al. (2000) Tryptophan Phosphorescence Study of Enzyme Flexibility and Unfolding in Laboratory-Evolved Thermostable Esterases Biochemistry; Vol. 39; No. 16;

Miyazaki, Kentaro; Wintrode, Patrick L. et al. (2000) Directed evolution study of temperature adaptation in a psychrophilic enzyme Journal of Molecular Biology; Vol. 297; No. 4;

May, Oliver; Nguyen, Peter T. et al. (2000) Inverting enantioselectivity by directed evolution of hydantoinase for improved production of L-methionine Nature Biotechnology; Vol. 18; No. 3;

Miyazaki, Kentaro; Arnold, Frances H. (1999) Exploring Nonnatural Evolutionary Pathways by Saturation Mutagenesis: Rapid Improvement of Protein Function Journal of Molecular Evolution; Vol. 49; No. 6;

Michnick, Stephen W.; Arnold, Frances H. (1999) “Itching” for new strategies in protein engineering Nature Biotechnology; Vol. 17; No. 12;

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Joo, Hyun; Lin, Zhanglin et al. (1999) Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation Nature; Vol. 399; No. 6737;

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Lin, Zhanglin; Thorsen, Todd et al. (1999) Functional Expression of Horseradish Peroxidase in E. coli by Directed Evolution Biotechnology Progress; Vol. 15; No. 3;

Schmidt-Dannert, Claudia; Arnold, Frances H. (1999) Directed evolution of industrial enzymes Trends in Biotechnology; Vol. 17; No. 4;

Arnold, Frances H.; Volkov, Alexander A. (1999) Directed evolution of biocatalysts Current Opinion in Chemical Biology; Vol. 3; No. 1;

Zhao, Huimin; Arnold, Frances H. (1999) Directed evolution converts subtilisin E into a functional equivalent of thermitase Protein Engineering; Vol. 12; No. 1;

Joo, Hyun; Lin, Zhanglin et al. (1999) Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation Redox Report; Vol. 4; No. 5;

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Arnold, Frances H. (1998) When blind is better: Protein design by evolution Nature Biotechnology; Vol. 16; No. 7;

Giver, Lori; Arnold, Frances H. (1998) Combinatorial protein design by in vitro recombination Current Opinion in Chemical Biology; Vol. 2; No. 3;

Arnold, Frances H. (1998) Enzyme engineering reaches the boiling point Proceedings of the National Academy of Sciences of the United States of America; Vol. 95; No. 5;

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Shao, Zhixin; Zhao, Huimin et al. (1998) Random-priming in vitro recombination: an effective tool for directed evolution Nucleic Acids Research; Vol. 26; No. 2;

Kuchner, Olga; Arnold, Frances H. (1997) Directed evolution of enzyme catalysts Trends in Biotechnology; Vol. 15; No. 12;

Moore, Jeffrey C.; Jin, Hua-Ming et al. (1997) Strategies for the in vitro evolution of protein function: enzyme evolution by random recombination of improved sequences Journal of Molecular Biology; Vol. 272; No. 3;

Zhao, Huimin; Arnold, Frances H. (1997) Combinatorial protein design: strategies for screening protein libraries Current Opinion in Structural Biology; Vol. 7; No. 4;

Zhao, Huimin; Arnold, Frances H. (1997) Functional and nonfunctional mutations distinguished by random recombination of homologous genes Proceedings of the National Academy of Sciences of the United States of America; Vol. 94; No. 15;

Pack, Daniel W.; Arnold, Frances H. (1997) Langmuir monolayer characterization of metal chelating lipids for protein targeting to membranes Chemistry and Physics of Lipids; Vol. 86; No. 2;

Chen, G.; Guan, Z. et al. (1997) A glucose sensing polymer Abstracts of Papers of the American Chemical Society; Vol. 213;

Chen, G.; Guan, Z. et al. (1997) A glucose-sensing polymer Abstracts of Papers of the American Chemical Society; Vol. 213;

Chen, Guohua; Guan, Zhibin et al. (1997) A glucose-sensing polymer Nature Biotechnology; Vol. 15; No. 4;

Zhao, Huimin; Arnold, Frances H. (1997) Optimization of DNA shuffling for high fidelity recombination Nucleic Acids Research; Vol. 25; No. 6;

Pack, Daniel W.; Chen, Guohua et al. (1997) A Metal-Chelating Lipid for 2D Protein Crystallization via Coordination of Surface Histidines Journal of the American Chemical Society; Vol. 119; No. 10;

Zhao, Huimin; Li, You et al. (1996) Strategy for the Directed Evolution of a Peptide Ligase Annals of the New York Academy of Sciences; Vol. 799; No. 1; Thirteenth International Enzyme Engineering Conference, 15-20 October 1995 , San Diego, CA

Shao, Zhixin; Arnold, Frances H. (1996) Engineering new functions and altering existing functions Current Opinion in Structural Biology; Vol. 6; No. 4;

Frey, Wolfgang; Schief, William R., Jr. et al. (1996) Two-dimensional protein crystallization via metal-ion coordination by naturally occurring surface histidines Proceedings of the National Academy of Sciences of the United States of America; Vol. 93; No. 10;

Moore, Jeffrey C.; Arnold, Frances H. (1996) Directed evolution of a para-nitrobenzyl esterase for aqueous-organic solvents Nature Biotechnology; Vol. 14; No. 4;

Johnson, R. D.; Wang, Z.-G. et al. (1996) Surface Site Heterogeneity and Lateral Interactions in Multipoint Protein Adsorption Journal of Physical Chemistry; Vol. 100; No. 12;

Johnson, Robert D.; Todd, Robert J. et al. (1996) Multipoint binding in metal-affinity chromatography: II. Effect of pH and imidazole on chromatographic retention of engineered histidine-containing cytochromes c Journal of Chromatography A; Vol. 725; No. 2;

You, L.; Arnold, F. H. (1996) Directed evolution of subtilisin E in Bacillus subtilis to enhance total activity in aqueous dimethylformamide Protein Engineering; Vol. 9; No. 1;

Johnson, Robert D.; Arnold, Frances H. (1995) Review: Multipoint binding and heterogeneity in immobilized metal affinity chromatography Biotechnology and Bioengineering; Vol. 48; No. 5;

Vidyasankar, Sundaresan; Dhal, Pradeep K. et al. (1995) Review: Selective ligand-exchange adsorbents prepared by template polymerization Biotechnology and Bioengineering; Vol. 48; No. 5;

Ng, Kingman; Pack, Daniel W. et al. (1995) Engineering Protein-Lipid Interactions: Targeting of Histidine-Tagged Proteins to Metal-Chelating Lipid Monolayers Langmuir; Vol. 11; No. 10;

Plunkett, Sean D.; Arnold, Frances H. (1995) Molecularly imprinted polymers on silica: selective supports for high-performance ligand-exchange chromatography Journal of Chromatography A; Vol. 708; No. 1;

Sasaki, Darryl Y.; Shnek, Deborah R. et al. (1995) Metal-Induced Dispersion of Lipid Aggregates: A Simple, Selective, and Sensitive Fluorescent Metal Ion Sensor Angewandte Chemie International Edition; Vol. 34; No. 8;

Johnson, Robert D.; Arnold, Frances H. (1995) The temkin isotherm describes heterogeneous protein adsorption Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology; Vol. 1247; No. 2;

Shnek, D. R.; Pack, D. W. et al. (1994) Specific Protein Attachment to Artificial Membranes via Coordination to Lipid-Bound Copper(II) Langmuir; Vol. 10; No. 7;

Arnold, Frances H.; Zhang, Ji-Hu (1994) Metal-mediated protein stabilization Trends in Biotechnology; Vol. 12; No. 5;

Todd, Robert J.; Johnson, Robert D. et al. (1994) Multiple-site binding interactions in metal-affinity chromatography: I. Equilibrium binding of engineered histidine-containing cytochromes c Journal of Chromatography A; Vol. 662; No. 1;

Arnold, Frances H. (1993) Protein engineering for unusual environments Current Opinion in Biotechnology; Vol. 4; No. 4;

Arnold, F. H. (1993) Engineering proteins for nonnatural environments FASEB Journal; Vol. 7; No. 9;

Chen, Keqin; Arnold, Frances H. (1993) Tuning the Activity of an Enzyme for Unusual Environments: Sequential Random Mutagenesis of Subtilisin E for Catalysis in Dimethylformamide Proceedings of the National Academy of Sciences of the United States of America; Vol. 90; No. 6;

Mallik, Sanku; Johnson, Robert D. et al. (1993) Selective recognition of bis-imidazoles by complementary bis-metal ion complexes Journal of the American Chemical Society; Vol. 115; No. 6;

Dhal, Pradeep K.; Arnold, Frances H. (1992) Metal-coordination interactions in the template-mediated synthesis of substrate-selective polymers: recognition of bis(imidazole) substrates by copper(II) iminodiacetate containing polymers Macromolecules; Vol. 25; No. 25;

Economou, Chariklia; Chen, Keqin et al. (1992) Random mutagenesis to enhance the activity of subtilisin in organic solvents: Characterization of Q103R subtilisin E Biotechnology and Bioengineering; Vol. 39; No. 6;

Martinez, Pascal; Van Dam, Mariana E. et al. (1992) Stabilization of substilisin E in organic solvents by site-directed mutagenesis Biotechnology and Bioengineering; Vol. 39; No. 2;

Martinez, Pascal; Van Dam, Mariana E. et al. (1992) Stabilization of substilisin E in organic solvents by site‐directed mutagenesis Biotechnology and Bioengineering; Vol. 39; No. 2;

Chen, Keqin; Arnold, Frances H. (1991) Enzyme Engineering for Nonaqueous Solvents: Random Mutagenesis to Enhance Activity of Subtilisin E in Polar Organic Media Bio/Technology; Vol. 9; No. 11;

Kellis, James T., Jr.; Todd, Robert J. et al. (1991) Protein Stabilization by Engineered Metal Chelation Bio/Technology; Vol. 9; No. 10;

Dhal, Pradeep K.; Arnold, Frances H. (1991) Template-mediated synthesis of metal-complexing polymers for molecular recognition Journal of the American Chemical Society; Vol. 113; No. 19;

Arnold, Frances H.; Haymore, Barry L. (1991) Engineered metal-binding proteins: purification to protein folding Science; Vol. 252; No. 5014;

Chen, Keqin; Robinson, Amy C. et al. (1991) Enzyme engineering for nonaqueous solvents. II. Additive effects of mutations on the stability and activity of subtilisin E in polar organic media Biotechnology Progress; Vol. 7; No. 2;

Suh, Sung-Sup; Haymore, Barry L. et al. (1991) Characterization of His-X_3-His sites in α-helices of synthetic metal-binding bovine somatotropin Protein Engineering, Design and Selection; Vol. 4; No. 3;

Todd, Robert J.; Van Dam, Mariana E. et al. (1991) Cu(II)-Binding properties of a cytochrome c with a synthetic metal-binding site: His-X_3-His in an α-helix Proteins; Vol. 10; No. 2;

Arnold, Frances H. (1991) Metal-Affinity Separations: A New Dimension in Protein Processing Bio/Technology; Vol. 9; No. 2;

Wuenschell, G. E.; Wen, E. et al. (1991) Chiral copper—chelate complexes alter selectivities in metal affinity protein partitioning Journal of Chromatography A; Vol. 543;

Arnold, Frances H. (1990) Engineering enzymes for non-aqueous solvents Trends in Biotechnology; Vol. 8; No. 9;

Suh, Sung-Sup; Arnold, Frances H. (1990) A mathematical model for metal affinity protein partitioning Biotechnology and Bioengineering; Vol. 35; No. 7;

Claeys, Ivan L.; Arnold, Frances H. (1989) Nuclear magnetic relaxation study of hindered rotational diffusion in gels AIChE Journal; Vol. 35; No. 2;

Arnold, Frances H.; Wolk, Steven et al. (1987) Structure, dynamics, and thermodynamics of mismatched DNA oligonucleotide duplexes d(CCCAGGG)_2 and d(CCCTGGG)_2 Biochemistry; Vol. 26; No. 13;

Arnold, F. H.; Schofield, S. A. et al. (1986) Analytical affinity chromatography: I. Local equilibrium theory and the measurement of association and inhibition constants Journal of Chromatography A; Vol. 355;

Arnold, F. H.; Blanch, H. W. (1986) Analytical affinity chromatography: II. Rate theory and the measurement of biological binding kinetics Journal of Chromatography A; Vol. 355;