Arnold, Frances

Combined from CaltechAUTHORS

• Alfonzo, Edwin and Hanley, Deirdre, el al. (2024) Biocatalytic Synthesis of α-Amino Esters via Nitrene C–H Insertion; Journal of the American Chemical Society; Vol. 146; No. 40; 27267–27273; 10.1021/jacs.4c09989
• Hanley, Deirdre and Li, Zi-Qi, el al. (2024) Stereospecific Enzymatic Conversion of Boronic Acids to Amines; Journal of the American Chemical Society; 10.1021/jacs.4c04190
• Almhjell, Patrick J. and Johnston, Kadina E., el al. (2024) The β-subunit of tryptophan synthase is a latent tyrosine synthase; Nature Chemical Biology; 10.1038/s41589-024-01619-z
• Mao, Runze and Gao, Shilong, el al. (2024) Biocatalytic, enantioenriched primary amination of tertiary C–H bonds; Nature Catalysis; Vol. 7; No. 5; 585-592; PMCID PMC11238567; 10.1038/s41929-024-01149-w
• Yang, Jason and Li, Francesca-Zhoufan, el al. (2024) Opportunities and Challenges for Machine Learning-Assisted Enzyme Engineering; ACS Central Science; Vol. 10; No. 2; 226-241; PMCID PMC10906252; 10.1021/acscentsci.3c01275
• Rogge, Torben and Zhou, Qingyang, el al. (2024) Iron Heme Enzyme-Catalyzed Cyclopropanations with Diazirines as Carbene Precursors: Computational Explorations of Diazirine Activation and Cyclopropanation Mechanism; Journal of the American Chemical Society; Vol. 146; No. 5; 2959-2966; 10.1021/jacs.3c06030
• Sarai, Nicholas S. and Fulton, Tyler J., el al. (2024) Directed evolution of enzymatic silicon-carbon bond cleavage in siloxanes; Science; Vol. 383; No. 6681; 438-443; 10.1126/science.adi5554
• Yang, Jason and Ducharme, Julie, el al. (2024) Correction to "DeCOIL: Optimization of Degenerate Codon Libraries for Machine Learning-Assisted Protein Engineering"; ACS Synthetic Biology; Vol. 13; No. 2; 692; 10.1021/acssynbio.3c00751
• Wackelin, Daniel J. and Mao, Runze, el al. (2024) Enzymatic Assembly of Diverse Lactone Structures: An Intramolecular C–H Functionalization Strategy; Journal of the American Chemical Society; Vol. 146; No. 2; 1580-1587; 10.1021/jacs.3c11722
• Qin, Zi-Yang and Gao, Shilong, el al. (2023) Biocatalytic Construction of Chiral Pyrrolidines and Indolines via Intramolecular C(sp³)–H Amination; ACS Central Science; Vol. 9; No. 12; 2333-2338; PMCID PMC10755850; 10.1021/acscentsci.3c00516
• Das, Anuvab and Long, Yueming, el al. (2023) Expanding Biocatalysis for Organosilane Functionalization: Enantioselective Nitrene Transfer to Benzylic Si–C–H Bonds; ACS Catalysis; Vol. 14; 148-152; 10.1021/acscatal.3c05370
• Mao, Runze and Taylor, Doris Mia, el al. (2023) Biocatalytic, stereoconvergent alkylation of (Z/E)-trisubstituted silyl enol ethers; Nature Synthesis; 10.1038/s44160-023-00431-2
• Gao, Shilong and Das, Anuvab, el al. (2023) Enzymatic Nitrogen Incorporation Using Hydroxylamine; Journal of the American Chemical Society; Vol. 145; No. 37; 20196-20201; PMCID PMC10560455; 10.1021/jacs.3c08053
• Mao, Runze and Wackelin, Daniel J., el al. (2023) Enantio- and Diastereoenriched Enzymatic Synthesis of 1,2,3-Polysubstituted Cyclopropanes from (Z/E)-Trisubstituted Enol Acetates; Journal of the American Chemical Society; Vol. 145; No. 29; 16176-16185; PMCID PMC10528827; 10.1021/jacs.3c04870
• Mao, Runze and Wackelin, Daniel J., el al. (2023) Enantio- and Diastereoenriched Enzymatic Synthesis of 1,2,3-Polysubstituted Cyclopropanes from (Z/E)-Trisubstituted Enol Acetates; PMCID PMC10120758; 10.21203/rs.3.rs-2802333/v1
• Danelius, Emma and Porter, Nicholas J., el al. (2023) MicroED Structure of a Protoglobin Reactive Carbene Intermediate; Journal of the American Chemical Society; Vol. 145; No. 13; 7159-7165; PMCID PMC10080679; 10.1021/jacs.2c12004
• Zhang, Juner and Maggiolo, Ailiena O., el al. (2023) Chemodivergent C(sp³)–H and C(sp²)–H cyanomethylation using engineered carbene transferases; Nature Catalysis; Vol. 6; No. 2; 152-160; PMCID PMC9983643; 10.1038/s41929-022-00908-x
• Schaus, Lucas and Das, Anuvab, el al. (2023) Protoglobin-Catalyzed Formation of cis-Trifluoromethyl-Substituted Cyclopropanes by Carbene Transfer; Angewandte Chemie International Edition; Vol. 62; No. 4; Art. No. e202208936; PMCID PMC9894577; 10.1002/anie.202208936
• Alfonzo, Edwin and Das, Anuvab, el al. (2022) New additions to the arsenal of biocatalysts for noncanonical amino acid synthesis; Current Opinion in Green and Sustainable Chemistry; Vol. 38; Art. No. 100701; PMCID PMC9770695; 10.1016/j.cogsc.2022.100701
• Athavale, Soumitra V. and Gao, Shilong, el al. (2022) Enzymatic Nitrogen Insertion into Unactivated C-H Bonds; Journal of the American Chemical Society; Vol. 144; No. 41; 19097-19105; PMCID PMC9612832; 10.1021/jacs.2c08285
• Danelius, Emma and Porter, Nicholas J., el al. (2022) MicroED structure of a protoglobin reactive carbene intermediate; 10.1101/2022.10.18.512604
• Zhang, Juner and Maggiolo, Ailiena O., el al. (2022) Chemodivergent C(sp³)–H and C(sp²)–H Cyanomethylation Using Engineered Carbene Transferases; 10.26434/chemrxiv-2022-z6pkw
• Athavale, Soumitra V. and Gao, Shilong, el al. (2022) Enzymatic Nitrogen Insertion into Unactivated C–H Bonds; 10.26434/chemrxiv-2022-w8sg3
• Calvó-Tusell, Carla and Liu, Zhen, el al. (2022) Reversing the enantioselectivity of enzymatic carbene N–H insertion through mechanism-guided protein engineering; 10.26434/chemrxiv-2022-f02xh
• Porter, Nicholas J. and Danelius, Emma, el al. (2022) Biocatalytic Carbene Transfer Using Diazirines; Journal of the American Chemical Society; Vol. 144; No. 20; 8892-8896; PMCID PMC9205183; 10.1021/jacs.2c02723
• Molina, Rosana S. and Rix, Gordon, el al. (2022) In vivo hypermutation and continuous evolution; Nature Reviews Methods Primers; Vol. 2; Art. No. 36; 10.1038/s43586-022-00119-5
• Miller, David C. and Lal, Ravi G., el al. (2022) Biocatalytic One-Carbon Ring Expansion of Aziridines to Azetidines via a Highly Enantioselective [1,2]-Stevens Rearrangement; Journal of the American Chemical Society; Vol. 144; No. 11; 4739-4745; PMCID PMC9022672; 10.1021/jacs.2c00251
• Wittmann, Bruce J. and Johnston, Kadina E., el al. (2022) evSeq: Cost-Effective Amplicon Sequencing of Every Variant in a Protein Library; ACS Synthetic Biology; Vol. 11; No. 3; 1313-1324; 10.1021/acssynbio.1c00592
• Arnold, Frances H. (2022) Innovation by evolution: bringing new chemistry to life; Biophysical Journal; Vol. 121; No. 3; 177a; 10.1016/j.bpj.2021.11.1846
• Liu, Zhen and Qin, Zi-Yang, el al. (2022) An Enzymatic Platform for Primary Amination of 1-Aryl-2-alkyl Alkynes; Journal of the American Chemical Society; Vol. 144; No. 1; 80-85; PMCID PMC8765727; 10.1021/jacs.1c11340
• Miller, David C. and Athavale, Soumitra V., el al. (2022) Combining chemistry and protein engineering for new-to-nature biocatalysis; Nature Synthesis; Vol. 1; No. 1; 18-23; PMCID PMC8995090; 10.1038/s44160-021-00008-x
• Athavale, Soumitra V. and Chen, Kai, el al. (2021) Engineering Enzymes for New‐to‐Nature Carbene Chemistry; ISBN 9783527347995; Transition Metal-Catalyzed Carbene Transformations; 95-138; 10.1002/9783527829170.ch4
• Wu, Zachary and Johnston, Kadina E., el al. (2021) Protein sequence design with deep generative models; Current Opinion in Chemical Biology; Vol. 65; 18-27; 10.1016/j.cbpa.2021.04.004
• Liu, Zhen and Calvó-Tusell, Carla, el al. (2021) Dual-function enzyme catalysis for enantioselective carbon–nitrogen bond formation; Nature Chemistry; Vol. 13; No. 12; 1166-1172; 10.1038/s41557-021-00794-z
• Wittmann, Bruce J. and Yue, Yisong, el al. (2021) Informed training set design enables efficient machine learning-assisted directed protein evolution; Cell Systems; Vol. 12; No. 11; 1026-1045; 10.1016/j.cels.2021.07.008
• Athavale, Soumitra V. and Gao, Shilong, el al. (2021) Biocatalytic, Intermolecular C−H Bond Functionalization for the Synthesis of Enantioenriched Amides; Angewandte Chemie International Edition; Vol. 60; No. 47; 24864-24869; PMCID PMC8578410; 10.1002/anie.202110873
• Watkins-Dulaney, Ella J. and Dunham, Noah P., el al. (2021) Asymmetric Alkylation of Ketones Catalyzed by Engineered TrpB; Angewandte Chemie International Edition; Vol. 60; No. 39; 21412-21417; PMCID PMC8440449; 10.1002/anie.202106938
• Wittmann, Bruce J. and Johnston, Kadina E, el al. (2021) Advances in machine learning for directed evolution; Current Opinion in Structural Biology; Vol. 69; 11-18; 10.1016/j.sbi.2021.01.008
• Arnold, Frances (2021) Innovation by evolution: bringing new chemistry to life; Acta Crystallographica Section A; Vol. A77; No. Supplement; Art. No. a70; 10.1107/S0108767321099293
• Sarai, Nicholas S. and Levin, Benjamin J., el al. (2021) Biocatalytic Transformations of Silicon—the Other Group 14 Element; ACS Central Science; Vol. 7; No. 6; 944-953; PMCID PMC8227617; 10.1021/acscentsci.1c00182
• Liu, Zhen and Arnold, Frances H. (2021) New-to-nature chemistry from old protein machinery: carbene and nitrene transferases; Current Opinion in Biotechnology; Vol. 69; 43-51; PMCID PMC8225731; 10.1016/j.copbio.2020.12.005
• Garcia-Borràs, Marc and Kan, S. B. Jennifer, el al. (2021) Origin and Control of Chemoselectivity in Cytochrome c Catalyzed Carbene Transfer into Si–H and N–H bonds; Journal of the American Chemical Society; Vol. 143; No. 18; 7114-7123; PMCID PMC9292473; 10.1021/jacs.1c02146
• Yang, Yang and Arnold, Frances H. (2021) Navigating the Unnatural Reaction Space: Directed Evolution of Heme Proteins for Selective Carbene and Nitrene Transfer; Accounts of Chemical Research; Vol. 54; No. 5; 1209-1225; PMCID PMC7931446; 10.1021/acs.accounts.0c00591
• Watkins-Dulaney, Ella and Straathof, Sabine, el al. (2021) Tryptophan Synthase: Biocatalyst Extraordinaire; ChemBioChem; Vol. 22; No. 1; 5-16; PMCID PMC7935429; 10.1002/cbic.202000379
• Pluchinsky, Adam J. and Wackelin, Daniel J., el al. (2020) High Throughput Screening with SAMDI Mass Spectrometry for Directed Evolution; Journal of the American Chemical Society; Vol. 142; No. 47; 19804-19808; 10.1021/jacs.0c07828
• Rix, Gordon and Watkins-Dulaney, Ella J., el al. (2020) Scalable continuous evolution for the generation of diverse enzyme variants encompassing promiscuous activities; Nature Communications; Vol. 11; Art. No. 5644; PMCID PMC7648111; 10.1038/s41467-020-19539-6
• Dunham, Noah P. and Arnold, Frances H. (2020) Nature's Machinery, Repurposed: Expanding the Repertoire of Iron-Dependent Oxygenases; ACS Catalysis; Vol. 10; No. 20; 12239-12255; PMCID PMC7710332; 10.1021/acscatal.0c03606
• Bähr, Susanne and Brinkmann-Chen, Sabine, el al. (2020) Selective Enzymatic Oxidation of Silanes to Silanols; Angewandte Chemie International Edition; Vol. 59; No. 36; 15507-15511; PMCID PMC7511438; 10.1002/anie.202002861
• Wu, Zachary and Yang, Kevin K., el al. (2020) Signal Peptides Generated by Attention-Based Neural Networks; ACS Synthetic Biology; Vol. 9; No. 8; 2154-2161; 10.1021/acssynbio.0c00219
• Wittmann, Bruce J. and Knight, Anders M., el al. (2020) Diversity-Oriented Enzymatic Synthesis of Cyclopropane Building Blocks; ACS Catalysis; Vol. 10; No. 13; 7112-7116; PMCID PMC7709968; 10.1021/acscatal.0c01888
• Jia, Zhi-Jun and Gao, Shilong, el al. (2020) Enzymatic Primary Amination of Benzylic and Allylic C(sp³)–H Bonds; Journal of the American Chemical Society; Vol. 142; No. 23; 10279-10283; 10.1021/jacs.0c03428
• Zhou, Andrew Z. and Chen, Kai, el al. (2020) Enzymatic Lactone-Carbene C‒H Insertion to Build Contiguous Chiral Centers; ACS Catalysis; Vol. 10; No. 10; 5393-5398; 10.1021/acscatal.0c01349
• Chen, Kai and Arnold, Frances H. (2020) Engineering cytochrome P450s for enantioselective cyclopropenation of internal alkynes; Journal of the American Chemical Society; Vol. 142; No. 15; 6891-6895; 10.1021/jacs.0c01313
• Yang, Yang and Arnold, Frances Hamilton (2020) Enantioselective C-H amination via directed evolution of cytochrome P450 enzymes
• Chen, Kai and Arnold, Frances H. (2020) Engineering new catalytic activities in enzymes; Nature Catalysis; Vol. 3; No. 3; 203-213; 10.1038/s41929-019-0385-5
• Watkins, Ella J. and Almhjell, Patrick J., el al. (2020) Direct enzymatic synthesis of a deep-blue fluorescent noncanonical amino acid from azulene and serine; ChemBioChem; Vol. 21; No. 1-2; 80-83; PMCID PMC6980211; 10.1002/cbic.201900497
• Goldberg, Nathaniel W. and Knight, Anders M., el al. (2019) Nitrene Transfer Catalyzed by a Non-Heme Iron Enzyme and Enhanced by Non-Native Small-Molecule Ligands; Journal of the American Chemical Society; Vol. 141; No. 50; 19585-19588; PMCID PMC6924163; 10.1021/jacs.9b11608
• Dick, Markus and Sarai, Nicholas S., el al. (2019) Tailoring Tryptophan Synthase TrpB for Selective Quaternary Carbon Bond Formation; Journal of the American Chemical Society; Vol. 141; No. 50; 19817-19822; PMCID PMC6939453; 10.1021/jacs.9b09864
• Goldberg, Nathaniel and Knight, Anders M., el al. (2019) Nitrene Transfer Catalyzed by a Non-Heme Iron Enzyme and Enhanced by Non-Native Small-Molecule Cofactors; 10.26434/chemrxiv.10062044.v1
• Bedbrook, Claire N. and Yang, Kevin K., el al. (2019) Machine learning-guided channelrhodopsin engineering enables minimally-invasive optogenetics; Nature Methods; Vol. 16; No. 11; 1176-1184; PMCID PMC6858556; 10.1038/s41592-019-0583-8
• Yang, Yang and Cho, Inha, el al. (2019) An enzymatic platform for the asymmetric amination of primary, secondary and tertiary C(sp³)–H bonds; Nature Chemistry; Vol. 11; No. 11; 987-993; PMCID PMC6998391; 10.1038/s41557-019-0343-5
• Arnold, Frances H. (2019) Innovation by Evolution: Bringing New Chemistry to Life (Nobel Lecture); Angewandte Chemie International Edition; Vol. 58; No. 41; 14420-14426; 10.1002/anie.201907729
• Romney, David K. and Sarai, Nicholas S., el al. (2019) Nitroalkanes as Versatile Nucleophiles for Enzymatic Synthesis of Noncanonical Amino Acids; ACS Catalysis; Vol. 9; No. 9; 8726-8730; PMCID PMC7709965; 10.1021/acscatal.9b02089
• Brandenberg, Oliver F. and Miller, David C., el al. (2019) Engineering Chemoselectivity in Hemoprotein-Catalyzed Indole Amidation; ACS Catalysis; Vol. 9; No. 9; 8271-8275; PMCID PMC6959474; 10.1021/acscatal.9b02508
• Yang, Kevin K. and Wu, Zachary, el al. (2019) Machine-learning-guided directed evolution for protein engineering; Nature Methods; Vol. 16; No. 8; 687-694; 10.1038/s41592-019-0496-6
• Zhang, Juner and Huang, Xiongyi, el al. (2019) Enantiodivergent α-Amino C–H Fluoroalkylation Catalyzed by Engineered Cytochrome P450s; Journal of the American Chemical Society; Vol. 141; No. 25; 9798-9802; PMCID PMC6666315; 10.1021/jacs.9b04344
• Brandenberg, Oliver F. and Chen, Kai, el al. (2019) Directed Evolution of a Cytochrome P450 Carbene Transferase for Selective Functionalization of Cyclic Compounds; Journal of the American Chemical Society; Vol. 141; No. 22; 8989-8995; 10.1021/jacs.9b02931
• Wu, Zachary and Kan, S. B. Jennifer, el al. (2019) Machine learning-assisted directed protein evolution with combinatorial libraries; Proceedings of the National Academy of Sciences of the United States of America; Vol. 116; No. 18; 8852-8858; PMCID PMC6500146; 10.1073/pnas.1901979116
• Zhang, Ruijie K. and Huang, Xiongyi, el al. (2019) Selective C-H bond functionalization with engineered heme proteins: new tools to generate complexity; Current Opinion in Chemical Biology; Vol. 49; 67-75; PMCID PMC6461521; 10.1016/j.cbpa.2018.10.004
• Arnold, Frances Hamilton (2019) Advances in directed protein evolution
• Arnold, Frances Hamilton (2019) Newest advances in enzymatic carbene- and nitrene-transfer catalysis
• Cho, Inha and Prier, Christopher K., el al. (2019) Enantioselective Aminohydroxylation of Styrenyl Olefins Catalyzed by an Engineered Hemoprotein; Angewandte Chemie International Edition; Vol. 58; No. 10; 3138-3142; 10.1002/anie.201812968
• Chen, Kai and Huang, Xiongyi, el al. (2019) Engineered Cytochrome c-Catalyzed Lactone-Carbene B–H Insertion; Synlett; Vol. 30; No. 4; 378-382; PMCID PMC6436545; 10.1055/s-0037-1611662
• Huang, Xiongyi and Garcia-Borràs, Marc, el al. (2019) A Biocatalytic Platform for Synthesis of Chiral α-Trifluoromethylated Organoborons; ACS Central Science; Vol. 5; No. 2; 270-276; PMCID PMC6396380; 10.1021/acscentsci.8b00679
• Cho, Inha and Jia, Zhi-Jun, el al. (2019) Genetically Tunable Enzymatic C‒H Amidation for Lactam Synthesis
• Zhang, Ruijie K. and Chen, Kai, el al. (2019) Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp³ C–H functionalization; Nature; Vol. 565; No. 7737; 67-72; PMCID PMC6440214; 10.1038/s41586-018-0808-5
• Arnold, Frances H. and Strickland, Donna H. (2019) Nobel Prizes 2018; Deutsche Lebensmittel-Rundschau; Vol. 115; No. 1; 40-41
• Almhjell, Patrick J. and Boville, Christina E., el al. (2018) Engineering enzymes for noncanonical amino acid synthesis; Chemical Society Reviews; Vol. 47; No. 24; 8980-8997; PMCID PMC6434697; 10.1039/c8cs00665b
• Chen, Kai and Zhang, Shuo-Qing, el al. (2018) Alternate heme ligation steers activity and selectivity in engineered cytochrome P450-catalyzed carbene transfer reactions; Journal of the American Chemical Society; Vol. 140; No. 48; 16402-16407; 10.1021/jacs.8b09613
• Boville, Christina E. and Scheele, Remkes A., el al. (2018) Engineered biosynthesis of β‐alkyl tryptophan analogs; Angewandte Chemie International Edition; Vol. 57; No. 45; 14764-14768; 10.1002/anie.201807998
• Yang, Kevin K. and Wu, Zachary, el al. (2018) Learned Protein Embeddings for Machine Learning; Bioinformatics; Vol. 34; No. 15; 2642-2648; PMCID PMC6061698; 10.1093/bioinformatics/bty178
• Romney, David K. and Arnold, Frances H., el al. (2018) Chemistry Takes a Bath: Reactions in Aqueous Media; Journal of Organic Chemistry; Vol. 83; No. 14; 7319-7322; 10.1021/acs.joc.8b01412
• Boville, Christina E. and Romney, David K., el al. (2018) Improved synthesis of 4-cyanotryptophan and other tryptophan analogs in aqueous solvent using variants of TrpB from Thermotoga maritima; Journal of Organic Chemistry; Vol. 83; No. 14; 7447-7452; PMCID PMC6054569; 10.1021/acs.joc.8b00517
• Lewis, Russell D. and Garcia-Borràs, Marc, el al. (2018) Catalytic iron-carbene intermediate revealed in a cytochrome c carbene transferase; Proceedings of the National Academy of Sciences of the United States of America; Vol. 115; No. 28; 7308-7313; PMCID PMC6048479; 10.1073/pnas.1807027115
• Buller, Andrew R. and van Roye, Paul, el al. (2018) Directed evolution mimics allosteric activation by stepwise tuning of the conformational ensemble; Journal of the American Chemical Society; Vol. 140; No. 23; 7256-7266; PMCID PMC5999571; 10.1021/jacs.8b03490
• Arnold, Frances H. (2018) Directed Evolution: Bringing New Chemistry to Life; Angewandte Chemie International Edition; Vol. 57; No. 16; 4143-4148; PMCID PMC5901037; 10.1002/anie.201708408
• Brandenberg, Oliver F. and Prier, Christopher K., el al. (2018) Stereoselective Enzymatic Synthesis of Heteroatom-Substituted Cyclopropanes; ACS Catalysis; Vol. 8; No. 4; 2629-2634; 10.1021/acscatal.7b04423
• Chen, Kai and Huang, Xiongyi, el al. (2018) Enzymatic construction of highly strained carbocycles; Science; Vol. 360; No. 6384; 71-75; PMCID PMC6104391; 10.1126/science.aar4239
• Knight, Anders M. and Kan, S. B. Jennifer, el al. (2018) Diverse engineered heme proteins enable stereodivergent cyclopropanation of unactivated alkenes; ACS Central Science; Vol. 4; No. 3; 372-377; PMCID PMC5879470; 10.1021/acscentsci.7b00548
• Zhang, Ruijie K. and Romney, David K., el al. (2018) Directed Evolution of Artificial Metalloenzymes: Bridging Synthetic Chemistry and Biology; ISBN 9783527341788; Artificial Metalloenzymes and MetalloDNAzymes in Catalysis; 137-170; 10.1002/9783527804085.ch5
• Kan, S. B. Jennifer and Huang, Xiongyi, el al. (2017) Genetically programmed chiral organoborane synthesis; Nature; Vol. 552; No. 7683; 132-136; PMCID PMC5819735; 10.1038/nature24996
• Cahn, Jackson K. B. and Brinkmann-Chen, Sabine, el al. (2017) Enzyme Nicotinamide Cofactor Specificity Reversal Guided by Automated Structural Analysis and Library Design; ISBN 978-1-4939-7294-4; Synthetic Metabolic Pathways; 15-26; 10.1007/978-1-4939-7295-1_2
• Bedbrook, Claire N. and Yang, Kevin K., el al. (2017) Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization; PLOS Computational Biology; Vol. 13; No. 10; Art. No. e1005786; PMCID PMC5695628; 10.1371/journal.pcbi.1005786
• Hammer, Stephan C. and Kubik, Grzegorz, el al. (2017) Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis; Science; Vol. 358; No. 6360; 215-218; 10.1126/science.aao1482
• Hammer, Stephan C. and Knight, Anders M., el al. (2017) Design and Evolution of Enzymes for Non-natural Chemistry; Current Opinion in Green and Sustainable Chemistry; Vol. 7; 23-30; 10.1016/j.cogsc.2017.06.002
• Brandenberg, Oliver F. and Fasan, Rudi, el al. (2017) Exploiting and engineering hemoproteins for abiological carbene and nitrene transfer reactions; Current Opinion in Biotechnology; Vol. 47; 102-111; PMCID PMC5617781; 10.1016/j.copbio.2017.06.005
• Romney, David K. and Murciano-Calles, Javier, el al. (2017) Unlocking reactivity of TrpB: a general biocatalytic platform for synthesis of tryptophan analogs; Journal of the American Chemical Society; Vol. 131; No. 39; 10769-10776; PMCID PMC5589443; 10.1021/jacs.7b05007
• Romney, David K. and Murciano-Calles, Javier, el al. (2017) Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues; Journal of the American Chemical Society; Vol. 139; No. 31; 10769-10776; PMCID PMC5589443; 10.1021/jacs.7b05007
• Loskot, Steven A. and Romney, David K., el al. (2017) Enantioselective Total Synthesis of Nigelladine A via Late-Stage C–H Oxidation Enabled by an Engineered P450 Enzyme; Journal of the American Chemical Society; Vol. 139; No. 30; 10196-10199; PMCID PMC5679227; 10.1021/jacs.7b05196
• Prier, Christopher K. and Zhang, Ruijie K., el al. (2017) Enantioselective, intermolecular benzylic C–H amination catalysed by an engineered iron-haem enzyme; Nature Chemistry; Vol. 9; No. 7; 629-634; PMCID PMC5555633; 10.1038/nchem.2783
• Romney, David K. and Murciano-Calles, Javier, el al. (2017) Engineered TrpB biocatalysts for the synthesis of tryptophan analogs
• Arnold, Frances H. (2017) New enzymes for green chemistry
• Bedbrook, Claire N. and Rice, Austin J., el al. (2017) Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins; Proceedings of the National Academy of Sciences of the United States of America; Vol. 114; No. 13; E2624-E2633; PMCID PMC5380088; 10.1073/pnas.1700269114
• Herwig, Lukas and Rice, Austin J., el al. (2017) Directed Evolution of a Bright Near-Infrared Fluorescent Rhodopsin Using a Synthetic Chromophore; Cell Chemical Biology; Vol. 24; No. 3; 415-425; PMCID PMC5357175; 10.1016/j.chembiol.2017.02.008
• Cahn, Jackson K. B. and Werlang, Caroline A., el al. (2017) A General Tool for Engineering the NAD/NADP Cofactor Preference of Oxidoreductases; ACS Synthetic Biology; Vol. 6; No. 2; 326-333; PMCID PMC8611728; 10.1021/acssynbio.6b00188
• Murciano-Calles, Javier and Buller, Andrew R., el al. (2017) Directed Evolution of an Allosteric Tryptophan Synthase to Create a Platform for Synthesis of Noncanonical Amino Acids; ISBN 978-3-319-50411-7; Directed Enzyme Evolution: Advances and Applications; 1-16; 10.1007/978-3-319-50413-1_1
• Buller, Andrew R. and van Roye, Paul, el al. (2016) Tryptophan synthase uses an atypical mechanism to achieve substrate specificity; Biochemistry; Vol. 55; No. 51; 7043-7046; PMCID PMC5207025; 10.1021/acs.biochem.6b01127
• Kan, S. B. Jennifer and Lewis, Russell D., el al. (2016) Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life; Science; Vol. 354; No. 6315; 1048-1051; PMCID PMC5243118; 10.1126/science.aah6219
• Hernandez, Kari E. and Renata, Hans, el al. (2016) Highly Stereoselective Biocatalytic Synthesis of Key Cyclopropane Intermediate to Ticagrelor; ACS Catalysis; Vol. 6; No. 11; 7810-7813; PMCID PMC5340201; 10.1021/acscatal.6b02550
• Renata, Hans and Lewis, Russell D., el al. (2016) Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes; Journal of the American Chemical Society; Vol. 138; No. 38; 12527-12533; PMCID PMC5042878; 10.1021/jacs.6b06823
• Murciano-Calles, Javier and Romney, David K., el al. (2016) A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation; Angewandte Chemie International Edition; Vol. 55; No. 38; 11577-11581; PMCID PMC5014574; 10.1002/anie.201606242
• Moraïs, Sarah and Stern, Johanna, el al. (2016) Enhancement of cellulosome-mediated deconstruction of cellulose by improving enzyme thermostability; Biotechnology for Biofuels; Vol. 9; Art. No. 164; PMCID PMC4973527; 10.1186/s13068-016-0577-z
• Herger, Michael and van Roye, Paul, el al. (2016) Synthesis of β-Branched Tryptophan Analogues Using an Engineered Subunit of Tryptophan Synthase; Journal of the American Chemical Society; Vol. 138; No. 27; 8388-8391; PMCID PMC4948191; 10.1021/jacs.6b04836
• Cahn, Jackson K. B. and Brinkmann-Chen, Sabine, el al. (2016) Artificial domain duplication replicates evolutionary history of ketol-acid reductoisomerases; Protein Science; Vol. 25; No. 7; 1241-1248; PMCID PMC4918412; 10.1002/pro.2852
• Dodani, Sheel C. and Kiss, Gert, el al. (2016) Discovery of a regioselectivity switch in nitrating P450s guided by molecular dynamics simulations and Markov models; Nature Chemistry; Vol. 8; No. 5; 419-425; PMCID PMC4843824; 10.1038/NCHEM.2474
• Prier, Christopher K. and Hyster, Todd K., el al. (2016) Asymmetric Enzymatic Synthesis of Allylic Amines: A Sigmatropic Rearrangement Strategy; Angewandte Chemie International Edition; Vol. 55; No. 15; 4711-4715; PMCID PMC4818679; 10.1002/anie.201601056
• Chang, Chia-Jung and Lee, Cheng-Chung, el al. (2016) Exploring the Mechanism Responsible for Cellulase Thermostability by Structure-Guided Recombination; PLoS ONE; Vol. 11; No. 3; Art. No. e0147485; PMCID PMC4795783; 10.1371/journal.pone.0147485
• Rice, Austin J. and Bedbrook, Claire N., el al. (2016) Rhodopsin Engineering through Structure-Guided Recombination; Biophysical Journal; Vol. 110; No. 3; 170A; 10.1016/j.bpj.2015.11.947
• Cahn, J. K. B. and Baumschlager, A., el al. (2016) Mutations in adenine-binding pockets enhance catalytic properties of NAD(P)H-dependent enzymes; Protein Engineering Design and Selection; Vol. 29; No. 1; 31-38; PMCID PMC4678007; 10.1093/protein/gzv057
• Buller, Andrew R. and Brinkmann-Chen, Sabine, el al. (2015) Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation; Proceedings of the National Academy of Sciences of the United States of America; Vol. 112; No. 47; 14599-14604; PMCID PMC4664345; 10.1073/pnas.1516401112
• Prier, Christopher K. and Arnold, Frances H. (2015) Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts; Journal of the American Chemical Society; Vol. 137; No. 44; 13992-14006; 10.1021/jacs.5b09348
• McIntosh, John A. and Heel, Thomas, el al. (2015) Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450; Journal of the American Chemical Society; Vol. 137; No. 43; 13861-13865; PMCID PMC4635421; 10.1021/jacs.5b07107
• Arnold, Frances H. (2015) The nature of chemical innovation: new enzymes by evolution; Quarterly Reviews of Biophysics; Vol. 48; No. 4; 404-410; 10.1017/S003358351500013X
• Bedbrook, Claire N. and Kato, Mihoko, el al. (2015) Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo; Chemistry and Biology; Vol. 22; No. 8; 1108-1121; PMCID PMC4546540; 10.1016/j.chembiol.2015.06.020
• McIsaac, R. Scott and Bedbrook, Claire N., el al. (2015) Recent advances in engineering microbial rhodopsins for optogenetics; Current Opinion in Structural Biology; Vol. 33; 8-15; PMCID PMC4641784; 10.1016/j.sbi.2015.05.001
• Cahn, Jackson K. B. and Brinkmann-Chen, Sabine, el al. (2015) Cofactor specificity motifs and the induced fit mechanism in class I ketol-acid reductoisomerases; Biochemical Journal; Vol. 468; No. 3; 475-484; PMCID PMC4550535; 10.1042/BJ20150183
• Farwell, Christopher C. and Zhang, Ruijie K., el al. (2015) Enantioselective Enzyme-Catalyzed Aziridination Enabled by Active-Site Evolution of a Cytochrome P450; ACS Central Science; Vol. 1; No. 2; 89-93; PMCID PMC4571169; 10.1021/acscentsci.5b00056
• Renata, Hans and Wang, Z. Jane, el al. (2015) Expanding the Enzyme Universe: Accessing Non-Natural Reactions by Mechanism-Guided Directed Evolution; Angewandte Chemie International Edition; Vol. 54; No. 11; 3351-3367; PMCID PMC4404643; 10.1002/anie.201409470
• Engqvist, Martin K. M. and McIsaac, R. Scott, el al. (2015) Directed Evolution of Gloeobacter violaceus Rhodopsin Spectral Properties; Journal of Molecular Biology; Vol. 427; No. 1; 205-220; 10.1016/j.jmb.2014.06.015
• Hyster, Todd K. and Arnold, Frances H. (2015) P450_(BM3)-Axial Mutations: A Gateway to Non-Natural Reactivity; Israel Journal of Chemistry; Vol. 55; No. 1; 14-20; 10.1002/ijch.201400080
• Trudeau, Devin L. and Lee, Toni M., el al. (2014) Engineered thermostable fungal cellulases exhibit efficient synergistic cellulose hydrolysis at elevated temperatures; Biotechnology and Bioengineering; Vol. 111; No. 12; 2390-2397; 10.1002/bit.25308
• Heel, Thomas and McIntosh, John A., el al. (2014) Non-natural Olefin Cyclopropanation Catalyzed by Diverse Cytochrome P450s and Other Hemoproteins; ChemBioChem; Vol. 15; No. 17; 2556-2562; PMCID PMC4287214; 10.1002/cbic.201402286
• Hyster, Todd K. and Farwell, Christopher C., el al. (2014) Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C−H Amination; Journal of the American Chemical Society; Vol. 136; No. 44; 15505-15508; PMCID PMC4227740; 10.1021/ja509308v
• Brinkmann-Chen, S. and Cahn, J. K. B., el al. (2014) Uncovering rare NADH-preferring ketol-acid reductoisomerases; Metabolic Engineering; Vol. 26; 17-22; 10.1016/j.ymben.2014.08.003
• Dodani, Sheel C. and Cahn, Jackson K. B., el al. (2014) Structural, Functional, and Spectroscopic Characterization of the Substrate Scope of the Novel Nitrating Cytochrome P450 TxtE; ChemBioChem; Vol. 15; No. 15; 2259-2267; PMCID PMC4260628; 10.1002/cbic.201402241
• Renata, Hans and Wang, Z. Jane, el al. (2014) P450-catalyzed asymmetric cyclopropanation of electron-deficient olefins under aerobic conditions; Catalysis Science and Technology; Vol. 4; No. 10; 3640-3643; PMCID PMC4159215; 10.1039/c4cy00633j
• Flytzanis, Nicholas C. and Bedbrook, Claire N., el al. (2014) Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons; Nature Communications; Vol. 5; No. 9; Art. No. 4894; PMCID PMC4166526; 10.1038/ncomms5894
• McIsaac, R. Scott and Engqvist, Martin K. M., el al. (2014) Directed evolution of a far-red fluorescent rhodopsin; Proceedings of the National Academy of Sciences of the United States of America; Vol. 111; No. 36; 13034-13039; PMCID PMC4246972; 10.1073/pnas.1413987111
• Sun, Fei and Zhang, Wen-Bin, el al. (2014) Synthesis of bioactive protein hydrogels by genetically encoded SpyTag-SpyCatcher chemistry; Proceedings of the National Academy of Sciences of the United States of America; Vol. 111; No. 31; 11269-11274; PMCID PMC4128157; 10.1073/pnas.1401291111
• Lin, Paul P. and Rabe, Kersten S., el al. (2014) Isobutanol production at elevated temperatures in thermophilic Geobacillus thermoglucosidasius; Metabolic Engineering; Vol. 24; 1-8; 10.1016/j.ymben.2014.03.006
• Smith, Matthew A. and Arnold, Frances H. (2014) Designing libraries of chimeric proteins using SCHEMA recombination and RASPP; ISBN 978-1-4939-1052-6; Directed Evolution Library Creation: Methods and Protocols; 335-343; 10.1007/978-1-4939-1053-3_22
• Smith, Matthew A. and Arnold, Frances H. (2014) Noncontiguous SCHEMA Protein Recombination; ISBN 9781493910526; Directed Evolution Library Creation: Methods and Protocols; 345-352; 10.1007/978-1-4939-1053-3_23
• Wang, Jane Z. and Renata, Hans, el al. (2014) Improved Cyclopropanation Activity of Histidine-Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran; Angewandte Chemie International Edition; Vol. 53; No. 26; 6810-6813; PMCID PMC4120663; 10.1002/anie.201402809
• Farwell, Christopher C. and McIntosh, John A., el al. (2014) Enantioselective Imidation of Sulfides via Enzyme-Catalyzed Intermolecular Nitrogen-Atom Transfer; Journal of the American Chemical Society; Vol. 136; No. 24; 8766-8771; PMCID PMC4154708; 10.1021/ja503593n
• Arnold, Frances H. and Meyerowitz, Joseph T. (2014) Synthetic biology: Engineering explored; Nature; Vol. 509; No. 7499; 166-167; 10.1038/509166a
• McIntosh, John A. and Farwell, Christopher C., el al. (2014) Expanding P450 catalytic reaction space through evolution and engineering; Current Opinion in Chemical Biology; Vol. 19; 126-134; PMCID PMC4008644; 10.1016/j.cbpa.2014.02.001
• Ener, M. E. and Coelho, P. S., el al. (2014) Photo-initiated and electron transfer reactivity of ruthenium-labeled cytochrome P450; Journal of Biological Inorganic Chemistry; Vol. 19; No. S1; S219; 10.1007/s00775-014-1095-8
• Coelho, P. S. and Arnold, F. H., el al. (2014) Synthetic Biology Approaches for Organic Synthesis; ISBN 978-0-08-097743-0; Comprehensive Organic Synthesis II; 390-420; 10.1016/B978-0-08-097742-3.00931-9
• Trudeau, Devin L. and Smith, Matthew A., el al. (2013) Innovation by homologous recombination; Current Opinion in Chemical Biology; Vol. 17; No. 6; 902-909; 10.1016/j.cbpa.2013.10.007
• Smith, Matthew A. and Bedbrook, Claire N., el al. (2013) Hypocrea jecorina Cellobiohydrolase I Stabilizing Mutations Identified Using Noncontiguous Recombination; ACS Synthetic Biology; Vol. 2; No. 12; 690-696; 10.1021/sb400010m
• Wang, Z. Jane and Peck, Nicole E., el al. (2013) Cytochrome P450-catalyzed insertion of carbenoids into N–H bonds; Chemical Science; Vol. 5; No. 2; 598-601; PMCID PMC3906682; 10.1039/c3sc52535j
• Arnold, Frances H. (2013) Expanding the enzyme universe through a marriage of chemistry and evolution; ISBN 978-981-4603-82-9; New chemistry and new opportunities from the expanding protein universe; 84-89; 10.1142/9789814603836_0014
• Zhang, Wen-Bin and Sun, Fei, el al. (2013) Controlling Macromolecular Topology with Genetically Encoded SpyTag-SpyCatcher Chemistry; Journal of the American Chemical Society; Vol. 135; No. 37; 13988-13997; 10.1021/ja4076452
• Zhang, Wen-Bin and Sun, Fei, el al. (2013) Cellular synthesis of non-linear proteins
• McIntosh, John A. and Coelho, Pedro S., el al. (2013) Enantioselective Intramolecular C-H Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo; Angewandte Chemie International Edition; Vol. 52; No. 35; 9309-9312; PMCID PMC3988694; 10.1002/anie.201304401
• Wu, Indira and Heel, Thomas, el al. (2013) Role of cysteine residues in thermal inactivation of fungal Cel6A cellobiohydrolases; Biochimica et Biophysica Acta - Proteins and Proteomics; Vol. 1834; No. 8; 1539-1544; 10.1016/j.bbapap.2013.05.003
• Coelho, Pedro S. and Wang, Z. Jane, el al. (2013) A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo; Nature Chemical Biology; Vol. 9; No. 8; 485-487; PMCID PMC3720782; 10.1038/nchembio.1278
• Brinkmann-Chen, Sabine and Flock, Tilman, el al. (2013) General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH; Proceedings of the National Academy of Sciences of the United States of America; Vol. 110; No. 27; 10946-10951; PMCID PMC3704004; 10.1073/pnas.1306073110
• Wu, Indira and Arnold, Frances H. (2013) Engineered thermostable fungal Cel6A and Cel7A cellobiohydrolases hydrolyze cellulose efficiently at elevated temperatures; Biotechnology and Bioengineering; Vol. 110; No. 7; 1874-1883; 10.1002/bit.24864
• Lauchli, Ryan and Rabe, Kersten S., el al. (2013) High-Throughput Screening for Terpene-Synthase-Cyclization Activity and Directed Evolution of a Terpene Synthase; Angewandte Chemie International Edition; Vol. 52; No. 21; 5571-5574; PMCID PMC3828198; 10.1002/anie.201301362
• Smith, Matthew A. and Romero, Philip A., el al. (2013) Chimeragenesis of distantly-related proteins by noncontiguous recombination; Protein Science; Vol. 22; No. 2; 231-238; PMCID PMC3588919; 10.1002/pro.2202
• Coelho, Pedro S. and Brustad, Eric M., el al. (2013) Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes; Science; Vol. 339; No. 6117; 307-310; 10.1126/science.1231434
• Romero, Philip A. and Krause, Andreas, el al. (2013) Navigating the protein fitness landscape with Gaussian processes; Proceedings of the National Academy of Sciences of the United States of America; Vol. 110; No. 3; E193-E201; PMCID PMC3549130; 10.1073/pnas.1215251110
• Heinzelman, Pete and Romero, Philip A., el al. (2013) Efficient Sampling of SCHEMA Chimera Families to Identify Useful Sequence Elements; ISBN 9780123942920; Methods in Protein Design; 351-368; 10.1016/B978-0-12-394292-0.00016-3
• Romero, Philip A. and Shapiro, Mikhail G., el al. (2013) Directed Evolution of Protein-Based Neurotransmitter Sensors for MRI; ISBN 978-1-62703-344-2; Chemical Neurobiology : Methods and Protocols; 193-205; PMCID PMC3818115; 10.1007/978-1-62703-345-9_14
• Liu, Xiang and Bastian, Sabine, el al. (2012) Structure-guided engineering of Lactococcus lactis alcohol dehydrogenase LlAdhA for improved conversion of isobutyraldehyde to isobutanol; Journal of Biotechnology; Vol. 164; No. 2; 188-195; PMCID PMC3542407; 10.1016/j.jbiotec.2012.08.008
• Smith, Matthew A. and Rentmeister, Andrea, el al. (2012) A diverse set of family 48 bacterial glycoside hydrolase cellulases created by structure-guided recombination; FEBS Journal; Vol. 279; No. 24; 4453-4465; 10.1111/febs.12032
• Komor, Russell S. and Romero, Philip A., el al. (2012) Highly thermostable fungal cellobiohydrolase I (Cel7A) engineered using predictive methods; Protein Engineering, Design and Selection; Vol. 25; No. 12; 827-833; 10.1093/protein/gzs058
• Romero, Philip A. and Arnold, Frances H. (2012) Random Field Model Reveals Structure of the Protein Recombinational Landscape; PLoS Computational Biology; Vol. 8; No. 10; Art. No. e1002713; PMCID PMC3464211; 10.1371/journal.pcbi.1002713
• Brustad, Eric M. and Lelyveld, Victor S., el al. (2012) Structure-Guided Directed Evolution of Highly Selective P450-Based Magnetic Resonance Imaging Sensors for Dopamine and Serotonin; Journal of Molecular Biology; Vol. 422; No. 2; 245-262; PMCID PMC3418479; 10.1016/j.jmb.2012.05.029
• Snow, Christopher D. and Brustad, Eric, el al. (2012) High Resolution Models from Low Resolution Data: Recombination of Fragments for Crystallographic Structure Determination; Protein Science; Vol. 21; No. S1; 91-92
• Lee, Toni and Farrow, Mary, el al. (2012) Computational Thermostable Cellulase Engineering for Enhanced Biofuel Production; Protein Science; Vol. 21; No. S1; 71-72
• Lelyveld, Victor and Brustad, Eric, el al. (2012) Metalloprotein-based contrast sensors for neurochemical detection by MRI; Protein Science; Vol. 21; No. S1; 184
• Romero, Philip A. and Stone, Everett, el al. (2012) SCHEMA-Designed Variants of Human Arginase I and II Reveal Sequence Elements Important to Stability and Catalysis; ACS Synthetic Biology; Vol. 1; No. 6; 221-228; PMCID PMC3378063; 10.1021/sb300014t
• Chen, Mike M. Y. and Snow, Christopher D., el al. (2012) Comparison of random mutagenesis and semi-rational designed libraries for improved cytochrome P450 BM3-catalyzed hydroxylation of small alkanes; Protein Engineering, Design and Selection; Vol. 25; No. 4; 171-178; 10.1093/protein/gzs004
• Chen, Mike M. Y. and Coelho, Pedro S., el al. (2012) Utilizing Terminal Oxidants to Achieve P450-Catalyzed Oxidation of Methane; Advanced Synthesis and Catalysis; Vol. 354; No. 6; 964-968; 10.1002/adsc.201100833
• Bastian, Sabine and Arnold, Frances H. (2012) Reversal of NAD(P)H Cofactor Dependence by Protein Engineering; ISBN 9781617794834; Microbial Metabolic Engineering; 17-31; 10.1007/978-1-61779-483-4_2
• Jung, Sang Taek and Lauchli, Ryan, el al. (2011) Cytochrome P450: taming a wild type enzyme; Current Opinion in Biotechnology; Vol. 22; No. 6; 809-817; PMCID PMC3118264; 10.1016/j.copbio.2011.02.008
• Lee, Toni M. and Farrow, Mary F., el al. (2011) A structural study of Hypocrea jecorina Cel5A; Protein Science; Vol. 20; No. 11; 1935-1940; PMCID PMC3267957; 10.1002/pro.730
• Farrow, Mary F. and Arnold, Frances H. (2011) High Throughput Screening of Fungal Endoglucanase Activity in Escherichia coli; Journal of Visualized Experiments; Vol. 54; Art. No. e2942; PMCID PMC3217630; 10.3791/2942
• Rentmeister, Andrea and Brown, Tristan R., el al. (2011) Engineered Bacterial Mimics of Human Drug Metabolizing Enzyme CYP2C9; ChemCatChem; Vol. 3; No. 6; 1065-1071; 10.1002/cctc.201000452
• Bastian, Sabine and Liu, Xiang, el al. (2011) Engineered ketol-acid reductoisomerase and alcohol dehydrogenase enable anaerobic 2-methylpropan-1-ol production at theoretical yield in Escherichia coli; Metabolic Engineering; Vol. 13; No. 3; 345-352; 10.1016/j.ymben.2011.02.004
• Brustad, Eric M. and Arnold, Frances H. (2011) Optimizing non-natural protein function with directed evolution; Current Opinion in Chemical Biology; Vol. 15; No. 2; 201-210; PMCID PMC3080047; 10.1016/j.cbpa.2010.11.020
• Fasan, Rudi and Crook, Nathan C., el al. (2011) Improved Product-Per-Glucose Yields in P450-Dependent Propane Biotransformations Using Engineered Escherichia coli; Biotechnology and Bioengineering; Vol. 108; No. 3; 500-510; 10.1002/bit.22984
• Brenner, Katie and Arnold, Frances H. (2011) Self-Organization, Layered Structure, and Aggregation Enhance Persistence of a Synthetic Biofilm Consortium; PLoS ONE; Vol. 6; No. 2; Art. No. e16791; PMCID PMC3036657; 10.1371/journal.pone.0016791
• Lelyveld, Victor S. and Brustad, Eric, el al. (2011) Metal-Substituted Protein MRI Contrast Agents Engineered for Enhanced Relaxivity and Ligand Sensitivity; Journal of the American Chemical Society; Vol. 133; No. 4; 649-651; PMCID PMC3154012; 10.1021/ja107936d
• Mingardon, Florence and Bagert, John D., el al. (2011) Comparison of Family 9 Cellulases from Mesophilic and Thermophilic Bacteria; Applied and Environmental Microbiology; Vol. 77; No. 4; 1436-1442; PMCID PMC3067227; 10.1128/AEM.01802-10
• Lewis, Jared C. and Coelho, Pedro S., el al. (2011) Enzymatic functionalization of carbon-hydrogen bonds; Chemical Society Reviews; Vol. 40; No. 4; 2003-2021; PMCID PMC3064445; 10.1039/c0cs00067a
• Lewis, Jared C. and Mantovani, Simone M., el al. (2010) Combinatorial Alanine Substitution Enables Rapid Optimization of Cytochrome P450_(BM3) for Selective Hydroxylation of Large Substrates; ChemBioChem; Vol. 11; No. 18; 2502-2505; PMCID PMC4447097; 10.1002/cbic.201000565
• Heinzelman, Pete and Komor, Russell, el al. (2010) Efficient screening of fungal cellobiohydrolase class I enzymes for thermostabilizing sequence blocks by SCHEMA structure-guided recombination; Protein Engineering, Design and Selection; Vol. 23; No. 11; 871-880; 10.1093/protein/gzq063
• Farrow, Mary F. and Arnold, Frances H. (2010) Combinatorial Recombination of Gene Fragments to Construct a Library of Chimeras; Current Protocols in Protein Science; Vol. 62; No. 1; 26.2.1-26.2.20; 10.1002/0471140864.ps2602s61
• Acar, Murat and Pando, Bernardo F., el al. (2010) A General Mechanism for Network-Dosage Compensation in Gene Circuits; Science; Vol. 329; No. 5999; 1656-1660; PMCID PMC3138731; 10.1126/science.1190544
• Jäckel, Christian and Bloom, Jesse D., el al. (2010) Consensus Protein Design without Phylogenetic Bias; Journal of Molecular Biology; Vol. 399; No. 4; 541-546; PMCID PMC2904866; 10.1016/j.jmb.2010.04.039
• Shapiro, Mikhail G. and Westmeyer, Gil G., el al. (2010) Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine; Nature Biotechnology; Vol. 28; No. 3; 264-270; PMCID PMC3073400; 10.1038/nbt.1609
• Romero, Philip A. and Arnold, Frances H. (2009) Exploring protein fitness landscapes by directed evolution; Nature Reviews. Molecular Cell Biology; Vol. 10; No. 12; 866-876; PMCID PMC2997618; 10.1038/nrm2805
• Sawayama, Andrew M. and Chen, Michael M. Y., el al. (2009) A Panel of Cytochrome P450 BM3 Variants to Produce Drug Metabolites and Diversify Lead Compounds; Chemistry: a European Journal; Vol. 15; No. 43; 11723-11729; 10.1002/chem.200900643
• Sawayama, Andrew M. and Chen, Michael M. Y., el al. (2009) A Panel of Cytochrome P450 BM3 Variants to Produce Drug Metabolites and Diversify Lead Compounds; Chemistry: a European Journal; Vol. 15; No. 43; 11723-11729; PMCID PMC3118466; 10.1002/chem.200900643
• Lewis, Jared C. and Bastian, Sabine, el al. (2009) Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450_(BM3) demethylases; Proceedings of the National Academy of Sciences of the United States of America; Vol. 106; No. 39; 16550-16555; PMCID PMC2757845; 10.1073/pnas.0908954106
• Heinzelman, Pete and Snow, Christopher D., el al. (2009) SCHEMA Recombination of a Fungal Cellulase Uncovers a Single Mutation That Contributes Markedly to Stability; Journal of Biological Chemistry; Vol. 284; No. 39; 26229-26233; PMCID PMC2785310; 10.1074/jbc.C109.034058
• Dougherty, Michael J. and Arnold, Frances H. (2009) Directed evolution: new parts and optimized function; Current Opinion in Biotechnology; Vol. 20; No. 4; 486-491; PMCID PMC2775421; 10.1016/j.copbio.2009.08.005
• Bloom, Jesse D. and Arnold, Frances H. (2009) In the light of directed evolution: Pathways of adaptive protein evolution; Proceedings of the National Academy of Sciences of the United States of America; Vol. 106; No. Supple; 9995-10000; PMCID PMC2702793; 10.1073/pnas.0901522106
• Lewis, Jared C. and Arnold, Frances H. (2009) Catalysts on Demand: Selective Oxidations by Laboratory-Evolved Cytochrome P450 BM3; Chimia; Vol. 63; No. 6; 309-312; 10.2533/chimia.2009.309
• Heinzelman, Pete and Snow, Christopher D., el al. (2009) A family of thermostable fungal cellulases created by structure-guided recombination; Proceedings of the National Academy of Sciences of the United States of America; Vol. 106; No. 14; 5610-5615; PMCID PMC2667002; 10.1073/pnas.0901417106
• Tracewell, Cara A. and Arnold, Frances H. (2009) Directed enzyme evolution: climbing fitness peaks one amino acid at a time; Current Opinion in Chemical Biology; Vol. 13; No. 1; 3-9; PMCID PMC2703427; 10.1016/j.cbpa.2009.01.017
• Rentmeister, Andrea and Arnold, Frances H., el al. (2009) Chemo-enzymatic fluorination of unactivated organic compounds; Nature Chemical Biology; Vol. 5; No. 1; 26-28; PMCID PMC2713661; 10.1038/nchembio.128
• Koch, Daniel J. and Chen, Mike M., el al. (2009) In Vivo Evolution of Butane Oxidation by Terminal Alkane Hydroxylases AlkB and CYP153A6; Applied and Environmental Microbiology; Vol. 75; No. 2; 337-344; PMCID PMC2620723; 10.1128/AEM.01758-08
• Brenner, Katie and You, Lingchong, el al. (2009) Response to Goldman and Brown: Making sense of microbial consortia using ecology and evolution; Trends in Biotechnology; Vol. 27; No. 1; 4; 10.1016/j.tibtech.2008.10.004
• Arnold, F. H. (2009) How Proteins Adapt: Lessons from Directed Evolution; ISBN 978-087969870-6; Evolution: the Molecular Landscape; 41-46
• Fasan, Rudi and Meharenna, Yergalem T., el al. (2008) Evolutionary History of a Specialized P450 Propane Monooxygenase; Journal of Molecular Biology; Vol. 383; No. 5; 1069-1080; PMCID PMC2637765; 10.1016/j.jmb.2008.06.060
• Brenner, Katie and You, Lingchong, el al. (2008) Engineering microbial consortia: a new frontier in synthetic biology; Trends in Biotechnology; Vol. 26; No. 9; 483-489; 10.1016/j.tibtech.2008.05.004
• Balagaddé, Frederick K. and Song, Hao, el al. (2008) A synthetic Escherichia coli predator–prey ecosystem; Molecular Systems Biology; Vol. 4; Art. No. 187; PMCID PMC2387235; 10.1038/msb.2008.24
• Haseltine, Eric L. and Arnold, Frances H. (2008) Implications of Rewiring Bacterial Quorum Sensing; Applied and Environmental Microbiology; Vol. 74; No. 2; 437-445; PMCID PMC2223271; 10.1128/AEM.01688-07
• Fasan, Rudi and Chen, Mike M., el al. (2007) Engineered Alkane‐Hydroxylating Cytochrome P450_(BM3) Exhibiting Nativelike Catalytic Properties; Angewandte Chemie International Edition; Vol. 46; No. 44; 8414-8418; 10.1002/anie.200702616
• Brenner, Katie and Karig, David K., el al. (2007) Engineered bidirectional communication mediates a consensus in a microbial biofilm consortium; Proceedings of the National Academy of Sciences of the United States of America; Vol. 104; No. 44; 17300-17304; PMCID PMC2077251; 10.1073/pnas.0704256104
• Li, Yougen and Drummond, D. Allan, el al. (2007) A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments; Nature Biotechnology; Vol. 25; No. 9; 1051-1056; 10.1038/nbt1333
• Hawkins, Andrew C. and Arnold, Frances H., el al. (2007) Directed evolution of Vibrio fischeri LuxR for improved response to butanoyl-homoserine lactone; Applied and Environmental Microbiology; Vol. 73; No. 18; 5775-5781; PMCID PMC2074898; 10.1128/AEM.00060-07
• Carbone, Martina N. and Arnold, Frances H. (2007) Engineering by homologous recombination: exploring sequence and function within a conserved fold; Current Opinion in Structural Biology; Vol. 17; No. 4; 454-459; 10.1016/j.sbi.2007.08.005
• Bloom, Jesse D. and Lu, Zhongyi, el al. (2007) Evolution favors protein mutational robustness in sufficiently large populations; BMC Biology; Vol. 5; No. 29; PMCID PMC1995189; 10.1186/1741-7007-5-29
• Bloom, Jesse D. and Romero, Philip A., el al. (2007) Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution; Biology Direct; Vol. 2; Art. No. 17; PMCID PMC1914045; 10.1186/1745-6150-2-17
• Haseltine, Eric L. and Arnold, Frances H. (2007) Synthetic Gene Circuits: Design with Directed Evolution; Annual Review of Biophysics and Biomolecular Structure; Vol. 36; 1-19; 10.1146/annurev.biophys.36.040306.132600
• Landwehr, Marco and Carbone, Martina, el al. (2007) Diversification of Catalytic Function in a Synthetic Family of Chimeric Cytochrome P450s; Chemistry and Biology; Vol. 14; No. 3; 269-278; PMCID PMC1991292; 10.1016/j.chembiol.2007.01.009
• Arnold, Frances H. and Moore, Jeffrey C. (2007) Optimizing industrial enzymes by directed evolution; ISBN 9783540618690; New Enzymes for Organic Synthesis: Screening, Supply and Engineering; 1-14; 10.1007/bfb0103300
• Bloom, Jesse D. and Arnold, Frances H., el al. (2007) Breaking proteins with mutations: threads and thresholds in evolution; Molecular Systems Biology; Vol. 3; No. 1; Art. No. 76; PMCID PMC1800353; 10.1038/msb4100119
• Meyer, Michelle M. and Hochrein, Lisa, el al. (2006) Structure-guided SCHEMA recombination of distantly related β-lactamase; Protein Engineering, Design and Selection; Vol. 19; No. 12; 563-570; 10.1093/protein/gzl045
• Bloom, Jesse D. and Drummond, D. Allan, el al. (2006) Structural Determinants of the Rate of Protein Evolution in Yeast; Molecular Biology and Evolution; Vol. 23; No. 9; 1751-1761; 10.1093/molbev/msl040
• Collins, Cynthia H. and Leadbetter, Jared R., el al. (2006) Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR; Nature Biotechnology; Vol. 24; No. 6; 708-712; 10.1038/nbt1209
• Landwehr, Marco and Hochrein, Lisa, el al. (2006) Enantioselective α-Hydroxylation of 2-Arylacetic Acid Derivatives and Buspirone Catalyzed by Engineered Cytochrome P450 BM-3; Journal of the American Chemical Society; Vol. 128; No. 18; 6058-6059; PMCID PMC2551755; 10.1021/ja061261x
• Otey, Christopher R. and Landwehr, Marco, el al. (2006) Structure-Guided Recombination Creates an Artificial Family of Cytochromes P450; PLoS Biology; Vol. 4; No. 5; e112; PMCID PMC1431580; 10.1371/journal.pbio.0040112
• Bloom, Jesse D. and Labthavikul, Sy T., el al. (2006) Protein stability promotes evolvability; Proceedings of the National Academy of Sciences of the United States of America; Vol. 103; No. 15; 5869-5874; PMCID PMC1458665; 10.1073/pnas.0510098103
• Arnold, Frances H. (2006) Fancy footwork in the sequence space shuffle; Nature Biotechnology; Vol. 24; No. 3; 328-330; 10.1038/nbt0306-328
• Udit, Andrew K. and Hill, Michael G., el al. (2006) Pyrene-Wired Heme Domain Cytochrome P450 BM3 Electrodes; ECS Meeting Abstracts; Vol. 501; No. 1; Abstract 9
• Otey, Christopher R. and Bandara, Geethani, el al. (2006) Preparation of human metabolites of propranolol using laboratory‐evolved bacterial cytochromes P450; Biotechnology and Bioengineering; Vol. 93; No. 3; 494-499; 10.1002/bit.20744
• Tobias, Alexander V. and Arnold, Frances H. (2006) Biosynthesis of novel carotenoid families based on unnatural carbon backbones: A model for diversification of natural product pathways; Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids; Vol. 1761; No. 2; 235-46; 10.1016/j.bbalip.2006.01.003
• Kubo, Takafumi and Peters, Matthew W., el al. (2006) Enantioselective Epoxidation of Terminal Alkenes to (R)- and (S)-Epoxides by Engineered Cytochromes P450 BM-3; Chemistry: a European Journal; Vol. 12; No. 4; 1216-1220; 10.1002/chem.200500584
• Meinhold, Peter and Peters, Matthew W., el al. (2005) Direct Conversion of Ethane to Ethanol by Engineered Cytochrome P450 BM3; ChemBioChem; Vol. 6; No. 10; 1765-1768; 10.1002/cbic.200500261
• Drummond, D. Allan and Bloom, Jesse D., el al. (2005) Why highly expressed proteins evolve slowly; Proceedings of the National Academy of Sciences of the United States of America; Vol. 102; No. 40; 14338-14343; PMCID PMC1242296; 10.1073/pnas.0504070102
• Yokobayashi, Yohei and Arnold, Frances H. (2005) A Dual Selection Module for Directed Evolution of Genetic Circuits; Natural Computing; Vol. 4; No. 3; 245-254; 10.1007/s11047-004-7442-x
• Bloom, Jesse D. and Meyer, Michelle M., el al. (2005) Evolving strategies for enzyme engineering; Current Opinion in Structural Biology; Vol. 15; No. 4; 447-452; 10.1016/j.sbi.2005.06.004
• Drummond, D. Allan and Iverson, Brent L., el al. (2005) Why High-error-rate Random Mutagenesis Libraries are Enriched in Functional and Improved Proteins; Journal of Molecular Biology; Vol. 350; No. 4; 806-816; 10.1016/j.jmb.2005.05.023
• Balagaddé, Frederick K. and You, Lingchong, el al. (2005) Long-Term Monitoring of Bacteria Undergoing Programmed Population Control in a Microchemostat; Science; Vol. 309; No. 5731; 137-140; 10.1126/science.1109173
• Udit, Andrew K. and Hindoyan, Nareen, el al. (2005) Protein−Surfactant Film Voltammetry of Wild-Type and Mutant Cytochrome P450 BM3; Inorganic Chemistry; Vol. 44; No. 12; 4109-4111; 10.1021/ic0483747
• Basu, Subhayu and Gerchman, Yoram, el al. (2005) A synthetic multicellular system for programmed pattern formation; Nature; Vol. 434; No. 7037; 1130-1134; 10.1038/nature03461
• Drummond, D. Allan and Silberg, Jonathan J., el al. (2005) On the conservative nature of intragenic recombination; Proceedings of the National Academy of Sciences of the United States of America; Vol. 102; No. 15; 5380-5385; PMCID PMC556249; 10.1073/pnas.0500729102
• Münzer, Dieter F. and Meinhold, Peter, el al. (2005) Stereoselective hydroxylation of an achiral cyclopentanecarboxylic acid derivative using engineered P450s BM-3; Chemical Communications; Vol. 2005; No. 20; 2597-2599; 10.1039/b501527h
• Umeno, Daisuke and Tobias, Alexander V., el al. (2005) Diversifying Carotenoid Biosynthetic Pathways by Directed Evolution; Microbiology and Molecular Biology Reviews; Vol. 69; No. 1; 51-78; PMCID PMC1082795; 10.1128/MMBR.69.1.51-78.2005
• Collins, Cynthia H. and Arnold, Frances H., el al. (2005) Directed evolution of Vibrio fischeri LuxR for increased sensitivity to a broad spectrum of acyl-homoserine lactones; Molecular Microbiology; Vol. 55; No. 3; 712-723; 10.1111/j.1365-2958.2004.04437.x
• Bloom, Jesse D. and Silberg, Jonathan J., el al. (2005) Thermodynamic prediction of protein neutrality; Proceedings of the National Academy of Sciences of the United States of America; Vol. 102; No. 3; 606-611; PMCID PMC545518; 10.1073/pnas.0406744102
• Malliaros, Jim and Quinn, Charles, el al. (2004) Association of antigens to ISCOMATRIX™ adjuvant using metal chelation leads to improved CTL responses; Vaccine; Vol. 22; No. 29-30; 3968-3975; 10.1016/j.vaccine.2004.03.054
• Udit, Andrew K. and Arnold, Frances H., el al. (2004) Cobaltocene-mediated catalytic monooxygenation using holo and heme domain cytochrome P450 BM3; Journal of Inorganic Biochemistry; Vol. 98; No. 9; 1547-1550; 10.1016/j.jinorgbio.2004.06.007
• Udit, Andrew K. and Hill, Michael G., el al. (2004) Reduction of Dioxygen Catalyzed by Pyrene-Wired Heme Domain Cytochrome P450 BM3 Electrodes; Journal of the American Chemical Society; Vol. 126; No. 33; 10218-10219; 10.1021/ja0466560
• Silberg, Jonathan J. and Endelman, Jeffrey B., el al. (2004) SCHEMA-Guided Protein Recombination; ISBN 9780121827939; Protein Engineering; 35-42; 10.1016/S0076-6879(04)88004-2
• Endelman, Jeffrey B. and Silberg, Jonathan J., el al. (2004) Site-directed protein recombination as a shortest-path problem; Protein Engineering, Design and Selection; Vol. 17; No. 7; 589-594; 10.1093/protein/gzh067
• Bloom, Jesse D. and Wilke, Claus O., el al. (2004) Stability and the Evolvability of Function in a Model Protein; Biophysical Journal; Vol. 86; No. 5; 2758-2764; PMCID PMC1304146; 10.1016/S0006-3495(04)74329-5
• You, Lingchong and Cox, Robert Sidney, III, el al. (2004) Programmed population control by cell-cell communication and regulated killing; Nature; Vol. 428; No. 6985; 868-871; 10.1038/nature02491
• Alcalde, Miguel and Farinas, Edgardo T., el al. (2004) Colorimetric High-Throughput Assay for Alkene Epoxidation Catalyzed by Cytochrome P450 BM-3 Variant 139-3; Journal of Biomolecular Screening; Vol. 9; No. 2; 141-146; 10.1177/1087057103261913
• Otey, Christopher R. and Silberg, Jonathan J., el al. (2004) Functional Evolution and Structural Conservation in Chimeric Cytochromes P450: Calibrating a Structure-Guided Approach; Chemistry and Biology; Vol. 11; No. 3; 309-318; 10.1016/j.chembiol.2004.02.018
• Umeno, Daisuke and Arnold, Frances H. (2004) Evolution of a Pathway to Novel Long-Chain Carotenoids; Journal of Bacteriology; Vol. 186; No. 5; 1531-1536; PMCID PMC344396; 10.1128/JB.186.5.1531-1536.2004
• Wong, Tuck Seng and Arnold, Frances H., el al. (2004) Laboratory evolution of cytochrome P450 BM-3 monooxygenase for organic cosolvents; Biotechnology and Bioengineering; Vol. 85; No. 3; 351-358; 10.1002/bit.10896
• Aguinaldo, Anna Marie and Arnold, Frances H. (2003) Staggered Extension Process (StEP) In Vitro Recombination; ISBN 159259395X; Directed Evolution Library Creation: Methods and Protocols; 105-110; 10.1385/1-59259-395-x:105
• Peters, Matthew W. and Meinhold, Peter, el al. (2003) Regio- and Enantioselective Alkane Hydroxylation with Engineered Cytochromes P450 BM-3; Journal of the American Chemical Society; Vol. 125; No. 44; 13442-13450; 10.1021/ja0303790
• Cirino, Patrick C. and Tang, Yi, el al. (2003) Global incorporation of norleucine in place of methionine in cytochrome P450 BM-3 heme domain increases peroxygenase activity; Biotechnology and Bioengineering; Vol. 83; No. 6; 729-734; 10.1002/bit.10718
• Salazar, Oriana and Cirino, Patrick C., el al. (2003) Thermostabilization of a Cytochrome P450 Peroxygenase; ChemBioChem; Vol. 4; No. 9; 891-893; 10.1002/cbic.200300660
• Umeno, Daisuke and Hiraga, Kaori, el al. (2003) Method to protect a targeted amino acid residue during random mutagenesis; Nucleic Acids Research; Vol. 31; No. 16; e91; PMCID PMC169983; 10.1093/nar/gng091
• Collins, Cynthia H. and Yokobayashi, Yohei, el al. (2003) Engineering proteins that bind, move, make and break DNA; Current Opinion in Biotechnology; Vol. 14; No. 4; 371-378; 10.1016/S0958-1669(03)00091-0
• Meyer, Michelle M. and Silberg, Jonathan J., el al. (2003) Library analysis of SCHEMA-guided protein recombination; Protein Science; Vol. 12; No. 8; 1686-1693; PMCID PMC2323955; 10.1110/ps.0306603
• Cirino, Patrick C. and Arnold, Frances H. (2003) A Self-Sufficient Peroxide-Driven Hydroxylation Biocatalyst; Angewandte Chemie International Edition; Vol. 42; No. 28; 3299-3301; 10.1002/anie.200351434
• Hiraga, Kaori and Arnold, Frances H. (2003) General Method for Sequence-independent Site-directed Chimeragenesis; Journal of Molecular Biology; Vol. 330; No. 2; 287-296; 10.1016/S0022-2836(03)00590-4
• Umeno, Daisuke and Arnold, Frances H. (2003) A C35 Carotenoid Biosynthetic Pathway; Applied and Environmental Microbiology; Vol. 69; No. 6; 3573-3579; PMCID PMC161527; 10.1128/AEM.69.6.3573-3579.2003
• Wintrode, Patrick L. and Zhang, Deqiang, el al. (2003) Protein Dynamics in a Family of Laboratory Evolved Thermophilic Enzymes; Journal of Molecular Biology; Vol. 327; No. 3; 745-757; 10.1016/S0022-2836(03)00147-5
• Yokobayashi, Yohei and Collins, Cynthia H., el al. (2003) Evolutionary Design Of Genetic Circuits And Cell-Cell Communications; Advances in Complex Systems; Vol. 6; No. 1; 37-45; 10.1142/S0219525903000700
• Bulter, Thomas and Alcalde, Miguel, el al. (2003) Functional Expression of a Fungal Laccase in Saccharomyces cerevisiae by Directed Evolution; Applied and Environmental Microbiology; Vol. 69; No. 2; 987-995; PMCID PMC143632; 10.1128/AEM.69.2.987-995.2003
• Yokobayashi, Yohei and Weiss, Ron, el al. (2002) Directed evolution of a genetic circuit; Proceedings of the National Academy of Sciences of the United States of America; Vol. 99; No. 26; 16587-16591; PMCID PMC139187; 10.1073/pnas.252535999
• Alcalde, Miguel and Bulter, Thomas, el al. (2002) Colorimetric Assays for Biodegradation of Polycyclic Aromatic Hydrocarbons by Fungal Laccases; Journal of Biomolecular Screening; Vol. 7; No. 6; 547-553; 10.1177/1087057102238629
• Umeno, Daisuke and Tobias, Alexander V., el al. (2002) Evolution of the C30 Carotenoid Synthase CrtM for Function in a C40 Pathway; Journal of Bacteriology; Vol. 184; No. 23; 6690-6699; PMCID PMC135437; 10.1128/JB.184.23.6690-6699.2002
• Glieder, Anton and Farinas, Edgardo T., el al. (2002) Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase; Nature Biotechnology; Vol. 20; No. 11; 1135-1139; 10.1038/nbt744
• Cirino, Patrick C. and Arnold, Frances H. (2002) Regioselectivity and Activity of Cytochrome P450 BM-3 and Mutant F87A in Reactions Driven by Hydrogen Peroxide; Advanced Synthesis and Catalysis; Vol. 344; No. 9; 932-937; 10.1002/1615-4169(200210)344:9<932::AID-ADSC932>3.0.CO;2-M
• Sun, Lianhong and Bulter, Thomas, el al. (2002) Modification of Galactose Oxidase to Introduce Glucose 6-Oxidase Activity; ChemBioChem; Vol. 3; No. 8; 781-783; 10.1002/1439-7633(20020802)3:8<781::AID-CBIC781>3.0.CO;2-8
• Voigt, Christopher A. and Martinez, Carlos, el al. (2002) Protein building blocks preserved by recombination; Nature Structural Biology; Vol. 9; No. 7; 553-558; 10.1038/nsb805
• Fu, Anne Y. and Chou, Hou-Pu, el al. (2002) An Integrated Microfabricated Cell Sorter; Analytical Chemistry; Vol. 74; No. 11; 2451-2457; 10.1021/ac0255330
• Cirino, Patrick C. and Arnold, Frances H. (2002) Protein engineering of oxygenases for biocatalysis; Current Opinion in Chemical Biology; Vol. 6; No. 2; 130-135; 10.1016/S1367-5931(02)00305-8
• Mayer, Kimberly M. and Arnold, Frances H. (2002) A Colorimetric Assay to Quantify Dehydrogenase Activity in Crude Cell Lysates; Journal of Biomolecular Screening; Vol. 7; No. 2; 135-140; 10.1177/108705710200700206
• Joern, John M and Meinhold, Peter, el al. (2002) Analysis of shuffled gene libraries; Journal of Molecular Biology; Vol. 316; No. 3; 643-656; 10.1006/jmbi.2001.5349
• Cirino, Patrick C. and Arnold, Frances H. (2002) Exploring the Diversity of Heme Enzymes through Directed Evolution; ISBN 9783527304233; Directed Molecular Evolution of Proteins: or How to Improve Enzymes for Biocatalysis; 215-243; 10.1002/3527600647.ch10
• Farinas, Edgardo T. and Bulter, Thomas, el al. (2001) Directed enzyme evolution; Current Opinion in Biotechnology; Vol. 12; No. 6; 545-551; 10.1016/S0958-1669(01)00261-0
• Wintrode, Patrick L. and Miyazaki, Kentaro, el al. (2001) Patterns of adaptation in a laboratory evolved thermophilic enzyme; Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology; Vol. 1549; No. 1; 1-8; 10.1016/S0167-4838(01)00226-6
• Morawski, Birgit and Quan, Sara, el al. (2001) Functional expression and stabilization of horseradish peroxidase by directed evolution in Saccharomyces cerevisiae; Biotechnology and Bioengineering; Vol. 76; No. 2; 99-107; 10.1002/bit.1149
• Sun, Lianhong and Petrounia, Ioanna P., el al. (2001) Expression and stabilization of galactose oxidase in Escherichia coli by directed evolution; Protein Engineering; Vol. 14; No. 9; 699-704; 10.1093/protein/14.9.699
• Sakamoto, Takeshi and Joern, John M., el al. (2001) Laboratory Evolution of Toluene Dioxygenase To Accept 4-Picoline as a Substrate; Applied and Environmental Microbiology; Vol. 67; No. 9; 3882-3887; PMCID PMC93105; 10.1128/AEM.67.9.3882-3887.2001
• Joern, John M. and Sakamoto, Takeshi, el al. (2001) A Versatile High Throughput Screen for Dioxygenase Activity Using Solid-Phase Digital Imaging; Journal of Biomolecular Screening; Vol. 6; No. 4; 219-223; 10.1177/108705710100600403
• Farinas, Edgardo T. and Schwaneberg, Ulrich, el al. (2001) Directed Evolution of a Cytochrome P450 Monooxygenase for Alkane Oxidation; Advanced Synthesis and Catalysis; Vol. 343; No. 6-7; 601-606; 10.1002/1615-4169(200108)343:6/7<601::AID-ADSC601>3.0.CO;2-9
• Sieber, Volker and Martinez, Carlos A., el al. (2001) Libraries of hybrid proteins from distantly related sequences; Nature Biotechnology; Vol. 19; No. 5; 456-460; 10.1038/88129
• Thorsen, Todd and Roberts, Richard W., el al. (2001) Dynamic Pattern Formation in a Vesicle-Generating Microfluidic Device; Physical Review Letters; Vol. 86; No. 18; 4163-4166; 10.1103/PhysRevLett.86.4163
• Schwaneberg, Ulrich and Otey, Christopher, el al. (2001) Cost-Effective Whole-Cell Assay for Laboratory Evolution of Hydroxylases in Escherichia coli; Journal of Biomolecular Screening; Vol. 6; No. 2; 111-117; 10.1177/108705710100600207
• Voigt, Christopher A. and Mayo, Stephen L., el al. (2001) Computational method to reduce the search space for directed protein evolution; Proceedings of the National Academy of Sciences of the United States of America; Vol. 98; No. 7; 3778-3783; PMCID PMC31129; 10.1073/pnas.051614498
• Arnold, Frances H. (2001) Combinatorial and computational challenges for biocatalyst design; Nature; Vol. 409; No. 6817; 253-257; 10.1038/35051731
• Arnold, Frances H. (2001) Preface; ISBN 9780120342556; Evolutionary Protein Design; ix-xi; 10.1016/s0065-3233(01)55000-7
• Arnold, Frances H. (2001) Evolutionary Protein Design; ISBN 978-0-12-034255-6
• Voigt, Christopher A. and Mayo, Stephen L., el al. (2001) Computationally Focusing the Directed Evolution of Proteins; Journal of Cellular Biochemistry; Vol. 84; No. S37; 58-63; 10.1002/jcb.10066
• Wintrode, Patrick L. and Arnold, Frances H. (2001) Temperature adaptation of enzymes: Lessons from laboratory evolution; ISBN 9780120342556; Evolutionary Protein Design; 161-225; 10.1016/s0065-3233(01)55004-4
• Wintrode, Patrick L. and Miyazaki, Kentaro, el al. (2000) Cold Adaptation of a Mesophilic Subtilisin-like Protease by Laboratory Evolution; Journal of Biological Chemistry; Vol. 275; No. 41; 31635-31640; 10.1074/jbc.M004503200
• Petrounia, Ioanna P. and Arnold, Frances H. (2000) Designed evolution of enzymatic properties; Current Opinion in Biotechnology; Vol. 11; No. 4; 325-330; 10.1016/s0958-1669(00)00107-5
• Schmidt-Dannert, Claudia and Umeno, Daisuke, el al. (2000) Molecular breeding of carotenoid biosynthetic pathways; Nature Biotechnology; Vol. 18; No. 7; 750-753; 10.1038/77319
• Morawski, Birgit and Lin, Zhanglin, el al. (2000) Functional expression of horseradish peroxidase in Saccharomyces cerevisiae and Pichia pastoris; Protein Engineering; Vol. 13; No. 5; 377-384; 10.1093/protein/13.5.377
• Gershenson, Anne and Schauerte, Joseph A., el al. (2000) Tryptophan Phosphorescence Study of Enzyme Flexibility and Unfolding in Laboratory-Evolved Thermostable Esterases; Biochemistry; Vol. 39; No. 16; 4658-4665; 10.1021/bi992473s
• Miyazaki, Kentaro and Wintrode, Patrick L., el al. (2000) Directed evolution study of temperature adaptation in a psychrophilic enzyme; Journal of Molecular Biology; Vol. 297; No. 4; 1015-1026; 10.1006/jmbi.2000.3612
• May, Oliver and Nguyen, Peter T., el al. (2000) Inverting enantioselectivity by directed evolution of hydantoinase for improved production of L-methionine; Nature Biotechnology; Vol. 18; No. 3; 317-320; 10.1038/73773
• Gershenson, Anne and Arnold, Frances H. (2000) Enzyme Stabilization by Directed Evolution; ISBN 978-1-4613-6884-7; Genetic Engineering: Principles and Methods; 55-76; 10.1007/978-1-4615-4199-8_5
• Michnick, Stephen W. and Arnold, Frances H. (1999) "Itching" for new strategies in protein engineering; Nature Biotechnology; Vol. 17; No. 12; 1159-1160; 10.1038/70699
• Miyazaki, Kentaro and Arnold, Frances H. (1999) Exploring Nonnatural Evolutionary Pathways by Saturation Mutagenesis: Rapid Improvement of Protein Function; Journal of Molecular Evolution; Vol. 49; No. 6; 716-720; 10.1007/pl00006593
• Gillam, Elizabeth M. J. and Aguinaldo, Anna Marie A., el al. (1999) Formation of Indigo by Recombinant Mammalian Cytochrome P450; Biochemical and Biophysical Research Communications; Vol. 265; No. 2; 469-472; 10.1006/bbrc.1999.1702
• Fu, Anne Y. and Spence, Charles, el al. (1999) A microfabricated fluorescence-activated cell sorter; Nature Biotechnology; Vol. 17; No. 11; 1109-1111; 10.1038/15095
• Spiller, Ben and Gershenson, Anne, el al. (1999) A structural view of evolutionary divergence; Proceedings of the National Academy of Sciences of the United States of America; Vol. 96; No. 22; 12305-12310; PMCID PMC22912
• Joo, Hyun and Arisawa, Akira, el al. (1999) A high-throughput digital imaging screen for the discovery and directed evolution of oxygenases; Chemistry and Biology; Vol. 6; No. 10; 699-706; 10.1016/S1074-5521(00)80017-4
• Volkov, Alexander A. and Shao, Zhixin, el al. (1999) Recombination and chimeragenesis by in vitro heteroduplex formation and in vivo repair; Nucleic Acids Research; Vol. 27; No. 18; e18; PMCID PMC148610; 10.1093/nar/27.18.e18
• Joo, Hyun and Lin, Zhanglin, el al. (1999) Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation; Nature; Vol. 399; No. 6737; 670-673; 10.1038/21395
• Arnold, Frances H. and Giver, Lori, el al. (1999) Directed Evolution of Mesophilic Enzymes into Their Thermophilic Counterparts; Annals of the New York Academy of Sciences; Vol. 870; No. 1; 400-403; 10.1111/j.1749-6632.1999.tb08913.x
• Lin, Zhanglin and Thorsen, Todd, el al. (1999) Functional Expression of Horseradish Peroxidase in E. coli by Directed Evolution; Biotechnology Progress; Vol. 15; No. 3; 467-471; 10.1021/bp990037r
• Schmidt-Dannert, Claudia and Arnold, Frances H. (1999) Directed evolution of industrial enzymes; Trends in Biotechnology; Vol. 17; No. 4; 135-136; 10.1016/s0167-7799(98)01283-9
• Arnold, Frances H. and Volkov, Alexander A. (1999) Directed evolution of biocatalysts; Current Opinion in Chemical Biology; Vol. 3; No. 1; 54-59; 10.1016/S1367-5931(99)80010-6
• Zhao, Huimin and Arnold, Frances H. (1999) Directed evolution converts subtilisin E into a functional equivalent of thermitase; Protein Engineering; Vol. 12; No. 1; 47-53; 10.1093/protein/12.1.47
• Arnold, Frances H. and Wintrode, Patrick L. (1999) Enzymes, Directed Evolution; ISBN 0471250589; Encyclopedia of Bioprocess Technology: Fermentation, Biocatalysis, and Bioseparation; Art. No. 80; 10.1002/0471250589.ebt080
• Joo, Hyun and Lin, Zhanglin, el al. (1999) Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation; Redox Report; Vol. 4; No. 5; 195-197; 10.1179/135100099101534918
• Giver, Lori and Gershenson, Anne, el al. (1998) Directed evolution of a thermostable esterase; Proceedings of the National Academy of Sciences of the United States of America; Vol. 95; No. 22; 12809-12813; PMCID PMC23604
• Arnold, Frances H. (1998) When blind is better: Protein design by evolution; Nature Biotechnology; Vol. 16; No. 7; 617-618; 10.1038/nbt0798-617
• Giver, Lori and Arnold, Frances H. (1998) Combinatorial protein design by in vitro recombination; Current Opinion in Chemical Biology; Vol. 2; No. 3; 335-338; 10.1016/S1367-5931(98)80006-9
• Arnold, Frances H. and Striegler, Susanne, el al. (1998) Chiral Ligand Exchange Adsorbents for Amines and Underivatized Amino Acids: 'Bait-and-Switch' Molecular Imprinting; ISBN 9780841235748; Molecular and Ionic Recognition with Imprinted Polymers; 109-118; 10.1021/bk-1998-0703.ch007
• Arnold, Frances H. (1998) Enzyme engineering reaches the boiling point; Proceedings of the National Academy of Sciences of the United States of America; Vol. 95; No. 5; 2035-2036; PMCID PMC33840
• Zhao, Huimin and Giver, Lori, el al. (1998) Molecular evolution by staggered extension process (StEP) in vitro recombination; Nature Biotechnology; Vol. 16; No. 3; 258-261; 10.1038/nbt0398-258
• Arnold, Frances H. (1998) Design by Directed Evolution; Accounts of Chemical Research; Vol. 31; No. 3; 125-131; 10.1021/ar960017f
• Shao, Zhixin and Zhao, Huimin, el al. (1998) Random-priming in vitro recombination: an effective tool for directed evolution; Nucleic Acids Research; Vol. 26; No. 2; 681-683; PMCID PMC147287; 10.1093/nar/26.2.681
• Kuchner, Olga and Arnold, Frances H. (1997) Directed evolution of enzyme catalysts; Trends in Biotechnology; Vol. 15; No. 12; 523-530; 10.1016/S0167-7799(97)01138-4
• Moore, Jeffrey C. and Jin, Hua-Ming, el al. (1997) Strategies for the in vitro evolution of protein function: enzyme evolution by random recombination of improved sequences; Journal of Molecular Biology; Vol. 272; No. 3; 336-347; 10.1006/jmbi.1997.1252
• Zhao, Huimin and Arnold, Frances H. (1997) Combinatorial protein design: strategies for screening protein libraries; Current Opinion in Structural Biology; Vol. 7; No. 4; 480-485; 10.1016/S0959-440X(97)80110-8
• Zhao, Huimin and Arnold, Frances H. (1997) Functional and nonfunctional mutations distinguished by random recombination of homologous genes; Proceedings of the National Academy of Sciences of the United States of America; Vol. 94; No. 15; 7997-8000; PMCID PMC21544
• Pack, Daniel W. and Arnold, Frances H. (1997) Langmuir monolayer characterization of metal chelating lipids for protein targeting to membranes; Chemistry and Physics of Lipids; Vol. 86; No. 2; 135-152; 10.1016/s0009-3084(97)02662-5
• Chen, G. and Guan, Z., el al. (1997) A glucose-sensing polymer; Abstracts of Papers of the American Chemical Society; Vol. 213; 234-PMSE
• Chen, G. and Guan, Z., el al. (1997) A glucose sensing polymer; Abstracts of Papers of the American Chemical Society; Vol. 213; 176-ANYL
• Chen, Guohua and Guan, Zhibin, el al. (1997) A glucose-sensing polymer; Nature Biotechnology; Vol. 15; No. 4; 354-357; 10.1038/nbt0497-354
• Zhao, Huimin and Arnold, Frances H. (1997) Optimization of DNA shuffling for high fidelity recombination; Nucleic Acids Research; Vol. 25; No. 6; 1307-1308; PMCID PMC146579; 10.1093/nar/25.6.1307
• Pack, Daniel W. and Chen, Guohua, el al. (1997) A Metal-Chelating Lipid for 2D Protein Crystallization via Coordination of Surface Histidines; Journal of the American Chemical Society; Vol. 119; No. 10; 2479-2487; 10.1021/ja964099e
• Zhao, Huimin and Li, You, el al. (1996) Strategy for the Directed Evolution of a Peptide Ligase; Annals of the New York Academy of Sciences; Vol. 799; No. 1; 1-5; 10.1111/j.1749-6632.1996.tb33169.x
• Shao, Zhixin and Arnold, Frances H. (1996) Engineering new functions and altering existing functions; Current Opinion in Structural Biology; Vol. 6; No. 4; 513-518; 10.1016/S0959-440X(96)80117-5
• Frey, Wolfgang and Schief, William R., Jr., el al. (1996) Two-dimensional protein crystallization via metal-ion coordination by naturally occurring surface histidines; Proceedings of the National Academy of Sciences of the United States of America; Vol. 93; No. 10; 4937-4941; PMCID PMC39383
• Moore, Jeffrey C. and Arnold, Frances H. (1996) Directed evolution of a para-nitrobenzyl esterase for aqueous-organic solvents; Nature Biotechnology; Vol. 14; No. 4; 458-467; 10.1038/nbt0496-458
• Johnson, R. D. and Wang, Z.-G., el al. (1996) Surface Site Heterogeneity and Lateral Interactions in Multipoint Protein Adsorption; Journal of Physical Chemistry; Vol. 100; No. 12; 5134-5139; 10.1021/jp9523682
• Johnson, Robert D. and Todd, Robert J., el al. (1996) Multipoint binding in metal-affinity chromatography: II. Effect of pH and imidazole on chromatographic retention of engineered histidine-containing cytochromes c; Journal of Chromatography A; Vol. 725; No. 2; 225-235; 10.1016/0021-9673(95)00992-2
• You, L. and Arnold, F. H. (1996) Directed evolution of subtilisin E in Bacillus subtilis to enhance total activity in aqueous dimethylformamide; Protein Engineering; Vol. 9; No. 1; 77-83; 10.1093/protein/9.1.77
• Vidyasankar, Sundaresan and Dhal, Pradeep K., el al. (1995) Review: Selective ligand-exchange adsorbents prepared by template polymerization; Biotechnology and Bioengineering; Vol. 48; No. 5; 431-436; 10.1002/bit.260480504
• Johnson, Robert D. and Arnold, Frances H. (1995) Review: Multipoint binding and heterogeneity in immobilized metal affinity chromatography; Biotechnology and Bioengineering; Vol. 48; No. 5; 437-443; 10.1002/bit.260480505
• Ng, Kingman and Pack, Daniel W., el al. (1995) Engineering Protein-Lipid Interactions: Targeting of Histidine-Tagged Proteins to Metal-Chelating Lipid Monolayers; Langmuir; Vol. 11; No. 10; 4048-4055; 10.1021/la00010a069
• Plunkett, Sean D. and Arnold, Frances H. (1995) Molecularly imprinted polymers on silica: selective supports for high-performance ligand-exchange chromatography; Journal of Chromatography A; Vol. 708; No. 1; 19-29; 10.1016/0021-9673(95)00378-Z
• Sasaki, Darryl Y. and Shnek, Deborah R., el al. (1995) Metal-Induced Dispersion of Lipid Aggregates: A Simple, Selective, and Sensitive Fluorescent Metal Ion Sensor; Angewandte Chemie International Edition; Vol. 34; No. 8; 905-907; 10.1002/anie.199509051
• Johnson, Robert D. and Arnold, Frances H. (1995) The temkin isotherm describes heterogeneous protein adsorption; Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology; Vol. 1247; No. 2; 293-297; 10.1016/0167-4838(95)00006-G
• Shnek, D. R. and Pack, D. W., el al. (1994) Specific Protein Attachment to Artificial Membranes via Coordination to Lipid-Bound Copper(II); Langmuir; Vol. 10; No. 7; 2382-2388; 10.1021/la00019a058
• Arnold, Frances H. and Zhang, Ji-Hu (1994) Metal-mediated protein stabilization; Trends in Biotechnology; Vol. 12; No. 5; 189-192; 10.1016/0167-7799(94)90081-7
• Todd, Robert J. and Johnson, Robert D., el al. (1994) Multiple-site binding interactions in metal-affinity chromatography: I. Equilibrium binding of engineered histidine-containing cytochromes c; Journal of Chromatography A; Vol. 662; No. 1; 13-26; 10.1016/0021-9673(94)85291-x
• Chung, Bong H. and Bailey, Darwin, el al. (1994) Metal affinity partitioning; ISBN 9780121821296; Aqueous Two-Phase Systems; 167-179; 10.1016/0076-6879(94)28017-7
• Arnold, Frances H. and Chen, Keqin, el al. (1993) Engineering Nonaqueous Solvent-Compatible Enzymes; ISBN 9780841225183; Biocatalyst Design for Stability and Specificity; 109-113; 10.1021/bk-1993-0516.ch008
• Umaña, Pablo and Kellis, James T., el al. (1993) Recombinant Protein Stabilization through Engineered Metal-Chelating Sites; ISBN 9780841225183; Biocatalyst Design for Stability and Specificity; 102-108; 10.1021/bk-1993-0516.ch007
• Arnold, Frances H. (1993) Protein engineering for unusual environments; Current Opinion in Biotechnology; Vol. 4; No. 4; 450-455; 10.1016/0958-1669(93)90011-k
• Arnold, F. H. (1993) Engineering proteins for nonnatural environments; FASEB Journal; Vol. 7; No. 9; 744-749; 10.1096/fasebj.7.9.8330682
• Chen, Keqin and Arnold, Frances H. (1993) Tuning the Activity of an Enzyme for Unusual Environments: Sequential Random Mutagenesis of Subtilisin E for Catalysis in Dimethylformamide; Proceedings of the National Academy of Sciences of the United States of America; Vol. 90; No. 6; 5618-5622; PMCID PMC46772
• Mallik, Sanku and Johnson, Robert D., el al. (1993) Selective recognition of bis-imidazoles by complementary bis-metal ion complexes; Journal of the American Chemical Society; Vol. 115; No. 6; 2518-2520; 10.1021/ja00059a063
• Dhal, Pradeep K. and Arnold, Frances H. (1992) Metal-coordination interactions in the template-mediated synthesis of substrate-selective polymers: recognition of bis(imidazole) substrates by copper(II) iminodiacetate containing polymers; Macromolecules; Vol. 25; No. 25; 7051-7059; 10.1021/ma00051a050
• Economou, Chariklia and Chen, Keqin, el al. (1992) Random mutagenesis to enhance the activity of subtilisin in organic solvents: Characterization of Q103R subtilisin E; Biotechnology and Bioengineering; Vol. 39; No. 6; 658-662; 10.1002/bit.260390610
• Martinez, Pascal and Van Dam, Mariana E., el al. (1992) Stabilization of substilisin E in organic solvents by site-directed mutagenesis; Biotechnology and Bioengineering; Vol. 39; No. 2; 141-147; 10.1002/bit.260390204
• Martinez, Pascal and Van Dam, Mariana E., el al. (1992) Stabilization of substilisin E in organic solvents by site‐directed mutagenesis; Biotechnology and Bioengineering; Vol. 39; No. 2; 141-147; 10.1002/bit.260390204
• Chung, Bong Hyun and Arnold, Frances H. (1992) Metal Affinity Partitioning of Phosphoproteins in Aqueous Two-Phase Systems; ISBN 9784431681823; Biochemical Engineering for 2001; 557-559; 10.1007/978-4-431-68180-9_148
• Chen, Keqin and Arnold, Frances H. (1991) Enzyme Engineering for Nonaqueous Solvents: Random Mutagenesis to Enhance Activity of Subtilisin E in Polar Organic Media; Bio/Technology; Vol. 9; No. 11; 1073-1077; 10.1038/nbt1191-1073
• Kellis, James T., Jr. and Todd, Robert J., el al. (1991) Protein Stabilization by Engineered Metal Chelation; Bio/Technology; Vol. 9; No. 10; 994-995; 10.1038/nbt1091-994
• Dhal, Pradeep K. and Arnold, Frances H. (1991) Template-mediated synthesis of metal-complexing polymers for molecular recognition; Journal of the American Chemical Society; Vol. 113; No. 19; 7417-7418; 10.1021/ja00019a046
• Arnold, Frances H. and Haymore, Barry L. (1991) Engineered metal-binding proteins: purification to protein folding; Science; Vol. 252; No. 5014; 1796-1797; 10.1126/science.1648261
• Chen, Keqin and Robinson, Amy C., el al. (1991) Enzyme engineering for nonaqueous solvents. II. Additive effects of mutations on the stability and activity of subtilisin E in polar organic media; Biotechnology Progress; Vol. 7; No. 2; 125-129; 10.1021/bp00008a007
• Suh, Sung-Sup and Haymore, Barry L., el al. (1991) Characterization of His-X_3-His sites in α-helices of synthetic metal-binding bovine somatotropin; Protein Engineering, Design and Selection; Vol. 4; No. 3; 301-305; 10.1093/protein/4.3.301
• Todd, Robert J. and Van Dam, Mariana E., el al. (1991) Cu(II)-Binding properties of a cytochrome c with a synthetic metal-binding site: His-X_3-His in an α-helix; Proteins; Vol. 10; No. 2; 156-161; 10.1002/prot.340100209
• Arnold, Frances H. (1991) Metal-Affinity Separations: A New Dimension in Protein Processing; Bio/Technology; Vol. 9; No. 2; 151-156; 10.1038/nbt0291-151
• Wuenschell, G. E. and Wen, E., el al. (1991) Chiral copper—chelate complexes alter selectivities in metal affinity protein partitioning; Journal of Chromatography A; Vol. 543; 345-354; 10.1016/S0021-9673(01)95786-3
• Arnold, Frances H. (1990) Engineering enzymes for non-aqueous solvents; Trends in Biotechnology; Vol. 8; No. 9; 244-249; 10.1016/0167-7799(90)90186-2
• Suh, S.-S. and Van Dam, M. E., el al. (1990) Novel Metal-Affinity Protein Separations; 10.1021/bk-1990-0427.ch010
• Suh, Sung-Sup and Arnold, Frances H. (1990) A mathematical model for metal affinity protein partitioning; Biotechnology and Bioengineering; Vol. 35; No. 7; 682-690; 10.1002/bit.260350705
• Claeys, Ivan L. and Arnold, Frances H. (1989) Nuclear magnetic relaxation study of hindered rotational diffusion in gels; AIChE Journal; Vol. 35; No. 2; 335-338; 10.1002/aic.690350223
• Arnold, Frances H. and Wolk, Steven, el al. (1987) Structure, dynamics, and thermodynamics of mismatched DNA oligonucleotide duplexes d(CCCAGGG)_2 and d(CCCTGGG)_2; Biochemistry; Vol. 26; No. 13; 4068-4075; 10.1021/bi00387a049
• Arnold, F. H. and Schofield, S. A., el al. (1986) Analytical affinity chromatography: I. Local equilibrium theory and the measurement of association and inhibition constants; Journal of Chromatography A; Vol. 355; 1-12; 10.1016/s0021-9673(01)97299-1
• Arnold, F. H. and Blanch, H. W. (1986) Analytical affinity chromatography: II. Rate theory and the measurement of biological binding kinetics; Journal of Chromatography A; Vol. 355; 13-27; 10.1016/S0021-9673(01)97300-5