Tianqiao and Chrissy Chen Institute for Neuroscience

The Tianqiao and Chrissy Chen Institute for Neuroscience at Caltech was founded in 2016 with the generous support of philanthropists Tianqiao Chen and Chrissy Luo. It is a key component of a neuroscience initiative that is geared toward deepening our understanding of the brain’s structure and how the brain works at its most basic level, as well as why and how it fails as a result of disease or through the aging process.

Monographs from CaltechAUTHORS

• Chen, Alex B.; Duque, Marc; et al. (2024) Norepinephrine changes behavioral state via astroglial purinergic signaling; PMCID PMC11142163; 10.1101/2024.05.23.595576
• Rosenthal, Isabelle A.; Bashford, Luke; et al. (2024) Visual context affects the perceived timing of tactile sensations elicited through intra-cortical microstimulation; PMCID PMC11118490; 10.1101/2024.05.13.593529
• Desingu Rajan, Ayyappa Raja; Huang, Yuanyun; et al. (2024) Generation of a zebrafish neurofibromatosis model via inducible knockout of nf2; 10.1101/2024.04.23.590787
• Gornet, James A. and Thomson, Matt (2024) Automated construction of cognitive maps with predictive coding; bioRxiv; 2023.09.18.558369; 10.1101/2023.09.18.558369
• Rich, Joseph M.; Moses, Lambda; et al. (2024) The impact of package selection and versioning on single-cell RNA-seq analysis; PMCID PMC11014608; 10.1101/2024.04.04.588111
• Booeshaghi, A. Sina; Galvez-Merchán, Ángel; et al. (2024) Algorithms for a Commons Cell Atlas; 10.1101/2024.03.23.586413
• Flynn, Michael James; Mayfield, Acacia M.; et al. (2024) Synthetic dosage-compensating miRNA circuits allow precision gene therapy for Rett syndrome; bioRxiv; 2024.03.13.584179; PMCID PMC10980028; 10.1101/2024.03.13.584179
• Israel, Uriah; Marks, Markus; et al. (2024) A Foundation Model for Cell Segmentation; bioRvix; 2023.11.17.567630; PMCID PMC10690226; 10.1101/2023.11.17.567630
• Jin, Zhiyang; Lakshmanan, Anupama; et al. (2023) Ultrasonic reporters of calcium for deep tissue imaging of cellular signals; PMCID PMC10659314; 10.1101/2023.11.09.566364
• Zhang, Shu; Xie, Na; et al. (2023) The Interferon-inducible NAMPT acts as a protein phosphoribosylase to restrict viral infection; PMCID PMC10614811; 10.1101/2023.10.12.562112
• Prakash, Sharan J.; Van Auken, Kimberly M.; et al. (2023) Semantic Representation of Neural Circuit Knowledge in Caenorhabditis elegans; PMCID PMC10168330; 10.1101/2023.04.28.538760
• Tran, Martin; Askary, Amjad; et al. (2023) Lineage motifs: developmental modules for control of cell type proportions; PMCID PMC10274800; 10.1101/2023.06.06.543925
• Srivastava, Vasudha; Hu, Jennifer L.; et al. (2023) Configurational entropy is an intrinsic driver of tissue structural heterogeneity; PMCID PMC10327153; 10.1101/2023.07.01.546933
• Gorin, Gennady; Vastola, John J.; et al. (2023) Studying stochastic systems biology of the cell with single-cell genomics data; PMCID PMC10245677; 10.1101/2023.05.17.541250
• Jiang, Jialong; Chen, Sisi; et al. (2023) D-SPIN constructs gene regulatory network models from multiplexed scRNA-seq data revealing organizing principles of cellular perturbation response; PMCID PMC10153191; 10.1101/2023.04.19.537364
• Hahn, Joshua; Monavarfeshani, Aboozar; et al. (2023) Evolution of neuronal cell classes and types in the vertebrate retina; PMCID PMC10104162; 10.1101/2023.04.07.536039
• Weatherbee, Bailey A. T.; Gantner, Carlos W.; et al. (2023) Transgene directed induction of a stem cell-derived human embryo model; 10.1101/2023.06.15.545082
• Xiong, Lingyun; Liu, Jing; et al. (2023) Direct androgen receptor regulation of sexually dimorphic gene expression in the mammalian kidney; PMCID PMC10187285; 10.1101/2023.05.06.539585
• Bjånes, David A.; Bashford, Luke; et al. (2023) Multi-channel intra-cortical micro-stimulation yields quick reaction times and evokes natural somatosensations in a human participant; 10.1101/2022.08.08.22278389
• Aflalo, Tyson; Chivukula, Srinivas; et al. (2023) Cognition through internal models: Mirror neurons as one manifestation of a broader mechanism; 10.1101/2022.09.06.506071
• Rosenthal, Isabelle A.; Bashford, Luke; et al. (2023) S1 represents multisensory contexts and somatotopic locations within and outside the bounds of the cortical homunculus; 10.1101/2022.08.29.505313
• Shimojo, Kensuke; Shimojo, Eiko; et al. (2023) Preservation of Conditioned Behavior Based on UV Light Sensitivity in Dissected Tail Halves of Planarians- a Proof by DNN; 10.1101/2022.10.30.514395
• Aquino, Tomas G.; Courellis, Hristos; et al. (2023) Encoding of predictive associations in human prefrontal and medial temporal neurons during Pavlovian conditioning; 10.1101/2023.02.10.528055
• Yang, Jie-Yoon; O’Connell, Thomas F.; et al. (2023) Restructuring of olfactory representations in the fly brain around odor relationships in natural sources; 10.1101/2023.02.15.528627
• Stevens, Taylor Anthony; Pinton Tomaleri, Giovani; et al. (2023) A nanobody-based strategy for rapid and scalable purification of native human protein complexes; 10.1101/2023.03.09.531980
• Bhat, Prashant; Chow, Amy; et al. (2023) 3D genome organization around nuclear speckles drives mRNA splicing efficiency; 10.1101/2023.01.04.522632
• Dylla, Kristina V.; O’Connell, Thomas F.; et al. (2023) Early life experience with natural odors modifies olfactory behavior through an associative process; 10.1101/2023.01.08.523155
• Kahan, Anat; Coughlin, Gerard M.; et al. (2023) Dysregulated mammalian estrus cycle rescued by timed activation of VIP neurons in the circadian pacemaker and late afternoon light exposure; 10.1101/2023.01.14.524075
• Pleiner, Tino; Hazu, Masami; et al. (2023) A selectivity filter in the EMC limits protein mislocalization to the ER; 10.1101/2022.11.29.518402
• Griggs, Whitney S.; Norman, Sumner L.; et al. (2023) Decoding Motor Plans Using a Closed-Loop Ultrasonic Brain-Machine Interface; 10.1101/2022.11.10.515371
• Wandelt, Sarah K.; Bjånes, David A.; et al. (2023) Online internal speech decoding from single neurons in a human participant; 10.1101/2022.11.02.22281775
• Guna, Alina; Stevens, Taylor A.; et al. (2023) MTCH2 is a mitochondrial outer membrane protein insertase; 10.1101/2022.09.15.508165
• van Timmeren, Tim; Dzinalija, Nadza; et al. (2023) Can the brain strategically go on automatic pilot? An fMRI study investigating the effect of if-then planning on behavioral flexibility; 10.1101/2022.11.13.516302
• Gera, Rani; Bar Or, Maya; et al. (2023) Characterizing habit learning in the human brain at the individual and group levels: a multi-modal MRI study; 10.1101/2022.12.12.520188
• Trautmann, Eric M.; Hesse, Janis K.; et al. (2023) Large-scale brain-wide neural recording in nonhuman primates; 10.1101/2023.02.01.526664
• Guan, Charles; Aflalo, Tyson; et al. (2022) Compositional coding of individual finger movements in human posterior parietal cortex and motor cortex enables ten-finger decoding; 10.1101/2022.12.07.22283227
• Ninova, Maria; Lomenick, Brett; et al. (2022) Pervasive SUMOylation of heterochromatin and piRNA pathway proteins; 10.1101/2022.08.15.504007
• Tashjian, Sarah M.; Wise, Toby; et al. (2022) Model-based prioritization for acquiring protection; 10.31234/osf.io/nv5u4
• Luebbert, Laura and Pachter, Lior (2022) Efficient querying of genomic reference databases with gget; 10.1101/2022.05.17.492392
• Nair, Aditya; Karigo, Tomomi; et al. (2022) An approximate line attractor in the hypothalamus that encodes an aggressive internal state; 10.1101/2022.04.19.488776
• Li, Ya-tang and Meister, Markus (2022) Functional Cell Types in the Mouse Superior Colliculus; 10.1101/2022.04.01.486789
• Sun, Jennifer J.; Ryou, Serim; et al. (2022) Self-Supervised Keypoint Discovery in Behavioral Videos; 10.48550/arXiv.2112.05121
• Guan, Charles; Aflalo, Tyson; et al. (2021) Preserved motor representations after paralysis; 10.1101/2021.10.07.463105
• Rusch, Tessa; Han, Yanting; et al. (2021) COVID-Dynamic: A large-scale multifaceted longitudinal study of socioemotional and behavioral change across the pandemic; 10.31234/osf.io/75eyx
• Gugel, Zhannetta V.; Maurais, Elizabeth; et al. (2021) Chronic exposure to odors at naturally occurring concentrations triggers limited plasticity in early stages of Drosophila olfactory processing; 10.1101/2021.09.03.458834
• Sun, Jennifer J.; Karigo, Tomomi; et al. (2021) The Multi-Agent Behavior Dataset: Mouse Dyadic Social Interactions; 10.48550/arXiv.2104.02710
• She, Liang; Benna, Marcus K.; et al. (2021) The neural code for face memory; 10.1101/2021.03.12.435023
• Weissbourd, Brandon; Momose, Tsuyoshi; et al. (2021) Functional modules within a distributed neural network control feeding in a model medusa; 10.1101/2021.02.22.432372
• Piacentino, Michael L.; Hutchins, Erica J.; et al. (2020) Temporal changes in plasma membrane lipid content induce endocytosis to regulate developmental epithelial-to-mesenchymal transition; 10.1101/2020.10.18.344523
• Jaffari, Matiar; Aflalo, Tyson; et al. (2020) Neural correlates of cognitive motor signals in primary somatosensory cortex; 10.1101/2020.04.20.041269
• Edmunds, C. E. R.; Bose, Devdeepta; et al. (2020) Accumulation is late and brief in preferential choice; 10.31234/osf.io/sa4zr